Binding type control device for forcing sleep fragmentation of receptor

Abstract

The utility model provides a binding type control device for forcing sleep fragmentation of a receptor, which comprises a stimulation generator for stimulating the receptor, a programmable controller for controlling the stimulation generator to operate according to a sleep interference program instruction, and a first power supply and a wireless transmitter which are connected with the programmable controller, the receiver is matched with the wireless transmitter and is connected with the stimulation generator; and the stimulation generator is arranged on the binding device and is powered by a second power supply. The whole living environment of the receptor is not used as an interference object or the receptor is not transferred between the living environment and the tested environment, differential interference can be carried out on the receptor under the condition that normal life of the receptor is not interfered, remote wireless control is introduced, an operation area for controlling interference is completely separated from an observation area for carrying out an experiment, and the experiment efficiency is improved. And mutual interference between the two is avoided.

Description

Technical Field

[0001] The utility model relates to the field of medical technology, in particular to a binding control device for forcing a receptor to fragment its sleep. Background Art

[0002] Sleep fragmentation refers to sleep interruptions and awakenings caused by various reasons during sleep. Frequent awakenings can cause sleep deprivation, leading to daytime sleepiness, mental confusion, memory loss, and inattention. Obstructive sleep apnea-hypopnea syndrome is one of them. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a sleep breathing disease of unknown etiology, with clinical manifestations of snoring with apnea and daytime sleepiness during sleep. Recurrent nocturnal hypoxia and hypercapnia caused by apnea can lead to complications such as hypertension, coronary heart disease, diabetes, and cerebrovascular disease, as well as traffic accidents, and even sudden death at night. OSAHS is a potentially fatal sleep breathing disease. Therefore, we need to conduct in-depth research on sleep breathing disorders. Making an animal sleep fragmentation model is one of the ways to explore the neural damage and pathophysiological mechanisms caused by sleep breathing disorders. Making an animal sleep fragmentation model requires the use of a corresponding control device that forces receptor sleep fragmentation.

[0003] In experiments to study the relationship between intervention-forced sleep fragmentation in recipient animals and their normal physiological and social activities, the animals' normal living conditions should be maintained as much as possible in order to minimize confounding factors in the experiment.

[0004] Existing devices for forcing small animals to undergo sleep fragmentation mainly adopt the following methods: horizontal platform sleep deprivation method, forced exercise method, gentle stimulation method, drug sleep deprivation method, etc.

[0005] The prior art has the following disadvantages:

[0006] ⅰ The water platform sleep deprivation model causes the animals to fall into the water repeatedly, which may cause pathological problems and interference;

[0007] ⅱ Forced exercise methods such as the deprivation rod model may cause the animals to get stuck or give up exercise, resulting in injury or invalidation of the experiment;

[0008] ⅲ Gentle stimulation requires high manual operation and is difficult to standardize. In addition, stimulation methods such as light and noise can easily interfere with the normal physiological activities of small animals.

[0009] ⅳDrug injection or feeding induction models will cause large errors due to individual differences in small animals' response to drugs, resulting in poor results;

[0010] At the same time, the above methods all have the limitation of relatively low throughput.

[0011] The existing patent discloses a composite control device for forcing receptor sleep fragmentation (authorization announcement number: CN215135459U). This scheme uses a countdown controller to control the movement of the rocking bed, and the movement of the rocking bed causes the effect of interrupting the sleep of mice, thereby obtaining a sleep fragmentation model. Its main defect is that the device interferes with the entire living environment of the mice. On the one hand, the mice cannot carry out normal physiological activities when they are disturbed, and on the other hand, it is impossible to perform differentiated interference on mice in the same environment.

[0012] At present, there is no device that can solve the above-mentioned technical problems, a device that can regulate (including time, frequency, cycle, etc.) the sleep physiological activities of the recipient through technical means and external intervention without interfering with the recipient's normal physiological and social activities (such as active eating, breastfeeding, socializing, etc.). Specifically, there is no binding control device that forces the recipient's sleep to be fragmented. Utility Model Content

[0013] In view of the defects in the prior art, the purpose of the utility model is to provide a binding control device for forcing a subject to sleep fragmentation.

[0014] In order to achieve the above-mentioned purpose, the utility model is implemented through the following technical solutions: a binding type control device for forcing a subject to sleep fragmentation, comprising:

[0015] A stimulation generator, used for stimulating the receptors, thereby causing the receptors to have fragmented sleep;

[0016] a programmable controller for controlling the stimulation generator to operate according to sleep disruption program instructions;

[0017] A first power supply, connected to the programmable controller, for supplying power to the programmable controller;

[0018] A wireless transmitter, connected to the programmable controller, for converting the electrical signal output by the programmable controller into radio waves;

[0019] a receiver matched with the wireless transmitter, the receiver being connected to the stimulation generator and configured to receive the radio waves emitted by the wireless transmitter and convert the radio waves into electrical signals for transmission to the stimulation generator;

[0020] Wherein, the stimulation generator is mounted on the binding device and is powered by a second power source.

[0021] A programmable controller is an electronic system that performs digital computing operations. It uses a programmable memory to store and execute operating commands such as logical operations, sequential control, timing, counting and arithmetic operations, and controls various types of mechanical activities or signal generation in this application through digital and analog input and output.

[0022] Wireless transmitter and receiver, the working principle of the wireless transmitter module is that when the electronic signal passes through the wireless transmitter module, the transmitting circuit inside the module converts the electronic signal into radio waves, which are then transmitted by the transmitting antenna; the working principle of the receiver is that when the radio wave passes through the receiver module, the receiving circuit inside the module converts the radio wave into an electronic signal for reception, thereby realizing the transmission of wireless signals.

[0023] It should be noted that programmable controllers, wireless transmitters and receivers are currently commonly used electrical components.

[0024] Furthermore, the receiver is mounted on the stimulation generator, and the second power source is a rechargeable battery.

[0025] Furthermore, the stimulation generator is a vibrator.

[0026] Furthermore, the programmable controller has a plurality of interfaces serving as output units.

[0027] Furthermore, the sleep interference program set in the programmable controller includes working time periods and frequencies.

[0028] Furthermore, the stimulation generator is an electric shock generator or a noise generator.

[0029] Furthermore, the vibrator has the function of adjusting vibration intensity and vibration mode.

[0030] Furthermore, when the stimulation generator is an electric shock generator, the electric shock generator has the function of adjusting the electric shock intensity and the electric shock mode; when the stimulation generator is a noise generator, the noise generator has the function of adjusting the noise intensity and the noise mode.

[0031] Compared with the prior art, the utility model has the following beneficial effects:

[0032] 1. The utility model does not take the overall living environment of the receptor as the interference object (compare with the technical solution with the authorization announcement number CN215135459U), or transfer the receptor between the living environment and the test environment (compare with the water platform and the deprivation rod model). At the same time, it can maintain the normal physiological activities of the receptor under the interference state, and can also achieve differentiated interference of the receptors in the same living environment with only one set of equipment.

[0033] 2. The interference method of the utility model has relatively little impact on the living state of the recipient (compared with traditional gentle stimulation and drug methods), and does not affect the normal physiological and social behavior of the recipient.

[0034] 3. The interference method provided by the utility model is easy to standardize and can more accurately control the number of sleep segments and the duration of a single sleep segment of the recipient animal.

[0035] 4. The binding control device for forcing the receptor sleep fragmentation provided by the utility model can significantly improve the experimental throughput, and theoretically can disturb the sleep of an unlimited number of receptor small animals at a time.

[0036] 5. The utility model adopts wireless connection of wireless transmitter and receiver and introduces remote wireless control, which can completely separate the operation area (programmable controller) for controlling interference from the observation area (stimulation generator tied to the receptor) for conducting experiments, thus avoiding mutual interference between the two. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0038] Figure 1 This is a schematic diagram of the connection mode of various functional modules in a binding-type control device for forcing a subject to sleep fragmentation in Example 1 of the present utility model. DETAILED DESCRIPTION

[0039] The utility model is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be pointed out that for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the utility model. These all belong to the protection scope of the utility model.

[0040] Embodiment 1:

[0041] See also Figure 1 , This embodiment provides a binding type control device for forcing a subject to sleep fragmentation, comprising: a first power source, an editable controller, a wireless transmitter, a receiver, a vibrator and a rechargeable battery;

[0042] The editable controller is connected to a first power supply, which is a 9V DC power supply, and supplies power to the programmable controller;

[0043] The programmable controller has 12 interfaces as output units, which can control 12 different sleep interference programs to run independently at the same time;

[0044] A wireless transmitter is connected to the programmable controller and converts the electrical signal output by the programmable controller into radio waves;

[0045] The receiver is matched with the wireless transmitter, the receiver is connected to the vibrator and installed on the vibrator, receives the radio waves sent by the wireless transmitter and converts the radio waves into electrical signals and transmits them to the vibrator;

[0046] A vibrator equipped with a receiver and a rechargeable battery is mounted on a binding device, such as a strap, which is then tied to the recipient animal. The vibrator is controlled by a programmable controller to vibrate, stimulating the receptor, thereby fragmenting the receptor's sleep. Each sleep disruption program can theoretically control an unlimited number of vibrators.

[0047] The experimental method for studying the influence of sleep fragmentation on physiological and social activities of small animals by using the binding control device forcing the recipient to sleep fragmentation provided in this embodiment is as follows:

[0048] 1. Connect the programmable controller PLC to the first power supply, enter the user command editing page in the programmable controller operation interface, edit the named 1-12 sleep interference programs separately, and set the specific working period and frequency of the running program, see Table 1;

[0049] 2. Connect the wireless transmitter corresponding to the vibrator that executes the same sleep interference program to the interface corresponding to the program. When the program needs to be executed, the wireless transmitter converts the electrical signal transmitted by the programmable controller through the interface into radio waves;

[0050] 3. The receiver matched with the wireless transmitter converts the received radio wave signal into an electrical signal and transmits it to the corresponding vibrator, controlling the vibrator to operate according to the program instructions. The vibration intensity and vibration mode can be directly set in the operation interface of each vibrator, see Table 1.

[0051] 4. The experimenter only needs to tie the recipient animals (rats are used in this application) to the corresponding vibrators (with rechargeable batteries and receivers inside) according to groups, then debug the entire device, and finally place the recipient animals in the experimental environment for experimental observation.

[0052] Table 1: Examples of commonly used sleep disruption procedures in rats

[0053]

[0054] Embodiment 2:

[0055] The scheme of Example 2 is basically the same as that of Example 1, the main difference being that the stimulation generator is an electric shock generator.

[0056] The electric shock generator has the function of adjusting the electric shock intensity and electric shock mode.

[0057] Embodiment 3:

[0058] Embodiment 3 is basically the same as Embodiment 1, the main difference being that the stimulus generator is a noise generator.

[0059] The noise generator has the function of adjusting the noise intensity and noise pattern.

[0060] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. In the absence of conflict, the embodiments of the present application and the features in the embodiments can be combined with each other at will.

Claims

1. A binding control device for forcing a subject to sleep fragmentation, characterized in that: include: A stimulation generator, used for stimulating the receptors, thereby causing the receptors to have fragmented sleep; a programmable controller for controlling the stimulation generator to operate according to sleep disruption program instructions; A first power supply, connected to the programmable controller, for supplying power to the programmable controller; A wireless transmitter, connected to the programmable controller, for converting the electrical signal output by the programmable controller into radio waves; a receiver matched with the wireless transmitter, the receiver being connected to the stimulation generator and configured to receive the radio waves emitted by the wireless transmitter and convert the radio waves into electrical signals for transmission to the stimulation generator; Wherein, the stimulation generator is mounted on the binding device and is powered by a second power source.

2. The control device for forcing a subject to sleep fragmentation according to claim 1 is characterized in that: The receiver is installed on the stimulation generator, and the second power source is a rechargeable battery.

3. The control device for forcing a subject to sleep fragmentation according to claim 2 is characterized in that: The stimulation generator is a vibrator.

4. The control device for forcing a subject to sleep fragmentation according to any one of claims 1 to 3, characterized in that: The programmable controller has two or more interfaces as output units.

5. The control device for forcing a subject to sleep fragmentation according to claim 1, characterized in that: The sleep interference program set in the programmable controller includes working time period and frequency.

6. The control device for forcing a subject to sleep fragmentation according to claim 1, characterized in that: The stimulation generator is an electric shock generator or a noise generator.

7. The control device for forcing a subject to sleep fragmentation according to claim 3 is characterized in that: The vibrator has the function of adjusting the vibration intensity and the vibration mode.

8. The control device for forcing a subject to sleep fragmentation according to claim 6 is characterized in that: When the stimulation generator is an electric shock generator, the electric shock generator has the function of adjusting the electric shock intensity and the electric shock mode; when the stimulation generator is a noise generator, the noise generator has the function of adjusting the noise intensity and the noise mode.

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