LED Alzheimer's disease phototherapy instrument based on intense pulsed light

Abstract

The utility model belongs to the technical field of medical instruments, and particularly relates to an LED (Light Emitting Diode) Alzheimer's disease phototherapy instrument based on intense pulsed light. High-peak optical power density pulsed light is generated to stimulate the growth and function recovery of neurons; an LED light source module, a driving module, a control module and a flexible shell are integrated and assembled to form an irradiation head of the phototherapy instrument, so that the irradiation head is convenient to hold and use; the LED light source module provides high-energy pulsed light; the control module generates a control signal to adjust parameters of the pulsed light; the driving module receives the control signal and generates a driving signal to drive the LED light source module; according to the phototherapy instrument, the pulse LED light is used for carrying out photobiological stimulation on the forehead of a person, the instantaneous power of the LED is improved through pulse driving, the light emitted by the LED can effectively penetrate through the skin to reach deep tissue, and photobiological therapy is achieved. The phototherapy instrument can greatly reduce the heat effect of LED luminescence, reduce the damage to the skin in the irradiation process, and ensure the safety of the treatment process.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and specifically relates to an LED light therapy device for Alzheimer's disease. Background Art

[0002] Alzheimer's disease is a neurodegenerative disease characterized by the damage and death of neurons in the brain, which is mainly manifested by symptoms such as progressive memory loss, cognitive decline and abnormal behavior. At present, the treatment of Alzheimer's disease mainly relies on drugs and rehabilitation training. However, the efficacy of drug treatment is limited and there are side effects, and the effect of rehabilitation training varies from person to person. Therefore, finding an effective treatment method has become an urgent need.

[0003] As a non-invasive and non-drug treatment, phototherapy has shown potential in many fields. It improves cell function and promotes tissue repair by introducing light sources of specific wavelengths and intensities. In other disease areas, such as skin diseases, trauma, and inflammation, phototherapy has been widely used and has achieved good results. Although the mechanism of phototherapy for Alzheimer's disease is not fully understood, some studies have shown that phototherapy can have a positive impact on pathological processes in many ways. First, phototherapy can improve mitochondrial function and increase cellular energy supply. Mitochondria produce adenosine triphosphate (ATP) in cells, which is the energy source required for normal cell function. In the brains of Alzheimer's patients, mitochondrial function is impaired, resulting in insufficient energy supply to brain cells. By introducing phototherapy, mitochondrial function recovery can be stimulated, cellular energy supply can be improved, and brain function can be improved. Secondly, phototherapy can also reduce neuronal damage and apoptosis and protect the health of the nervous system. There are a large number of β-amyloid plaques and neurofibrillary tangles in the brains of Alzheimer's patients. These pathological features damage the structure and function of neurons. Light therapy can reduce the occurrence of these pathological changes by reducing inflammation and oxidative stress, thereby protecting neurons from damage. In addition, light therapy may also alleviate the symptoms and pathological progression of Alzheimer's disease by improving the brain environment.

[0004] However, there are still some problems and challenges in the application of phototherapy in the treatment of Alzheimer's disease. First, the penetration depth of light in the brain is shallow, which limits the effectiveness of the treatment. In addition, due to the differences in pathological manifestations and symptoms among Alzheimer's patients, personalized phototherapy is also an issue that needs to be addressed. Currently, the light sources used for phototherapy are mainly lasers and LEDs. Laser phototherapy is limited by the millimeter-level laser spot area and is not suitable for larger area intervention treatments; the light energy density of the LED itself is much smaller than that of the laser, and the penetration depth of light with a large angle in the skin is limited, which limits the energy density that penetrates the skin to reach the target tissue, and sometimes even fails to reach the effective energy density threshold, affecting the effect of phototherapy. Summary of the invention

[0005] The purpose of the utility model is to provide a safe and efficient LED Alzheimer's disease phototherapy device based on intense pulsed light, which can avoid possible side effects and complications.

[0006] The utility model provides an LED Alzheimer's disease phototherapy device based on intense pulsed light, which stimulates the growth and functional recovery of neurons by generating high peak light power density pulsed light; specifically, it comprises an LED light source module, a drive module, a control module, a flexible housing and a heat dissipation module; the LED light source module, the drive module, the control module and the flexible housing are integrated and assembled into an irradiation head of the phototherapy device, which is convenient for operation and use; wherein:

[0007] The LED light source module is composed of an LED array, a flexible circuit substrate, a reflective film, a flexible shell and a headband; wherein the LED array is arranged on the front of the flexible circuit substrate, the flexible shell is fixed on the front of the flexible circuit substrate to isolate the patient's scalp and the LED array, the reflective film is arranged on the flexible circuit substrate to enhance the reflection effect of light; the headband is arranged on the flexible shell to facilitate user fixation so that the flexible shell fits the affected area.

[0008] The LED array is used to generate light of specific wavelength and intensity, has high energy density, can penetrate skin and tissue well, and directly act on damaged neurons.

[0009] In the LED array, the peak wavelength of the light generated by the LED chip is preferably between the red light and infrared light bands, that is, 630-1000nm, to maximize the stimulation of neuronal growth and recovery.

[0010] The LED array is arranged on the front of the flexible circuit substrate, and can be connected in five parallel and seven series. The flexible circuit board is provided with four fixing holes for fixing the LED array; the flexible circuit board is provided with multiple vias, which facilitates the design of appropriate support structures around the vias to enhance the structural strength of the flexible circuit board.

[0011] The utility model adopts PWM dimming control mode, and its duty cycle is controlled at 0.01%-50%, and the control frequency range is 0.2Hz-20KHz. The LED is driven by strong pulse mode, and the instantaneous light power of the LED is extremely high, and the strong light is emitted to penetrate deep into the tissue, but due to the duty cycle selection, the average light power is not too high, thereby avoiding the damage to human skin caused by the strong light and the heat generated by the LED under high power operation.

[0012] The driving module provides stable electric power drive for the LED light source module, ensuring the normal operation of the LED light source module and the stability of the phototherapy effect.

[0013] The control module adjusts the light intensity, light mode and light time of the LED light source module according to the condition of the Alzheimer's patient to maximize the stimulation of neuron growth and regeneration, is suitable for different treatment stages and changes in the disease, promotes the recovery of the lesion area, and achieves the best treatment effect.

[0014] Specifically, the control module provides a stable power supply to the microcontroller and the driver module through two step-down circuits. The microcontroller receives the user's key signals and generates corresponding control signals; these control signals are transmitted to the driver module through six inverters to adjust the working state of the LED array, such as the light therapy intensity and pulse frequency. By changing the duty cycle and frequency of the PWM signal, the LED array can emit light of different intensities and frequencies to achieve the light therapy effect for Alzheimer's disease. For the electrical schematic diagram of the control module, see Figure 4 shown.

[0015] The flexible shell has a certain curvature to conform to the curve of the human head, providing better comfort and use experience. The shell is made of skin-friendly materials to ensure safe and comfortable contact with the patient's skin.

[0016] The heat dissipation module, specifically an LED heat dissipation fence, is arranged outside the irradiation head to dissipate the heat generated by the phototherapy device, keep the temperature of the device within a safe range, and avoid adverse effects on patients due to overheating.

[0017] In addition, the LED light source module is also equipped with a temperature monitoring device to monitor the patient's skin temperature in real time to ensure a safe and comfortable treatment process. The monitoring device can promptly alarm or automatically adjust the power of the phototherapy device to keep the skin temperature within a safe range during treatment to avoid adverse effects on the patient.

[0018] In the present invention, the intense pulsed light in medicine refers to a light having a high peak power of more than 100 watts and a short pulse width of microseconds.

[0019] The utility model provides an LED Alzheimer's light therapy device based on intense pulsed light, which adopts pulse drive technology and effectively increases the output of light energy by increasing the instantaneous power of the LED. This intense pulsed light can penetrate the skin and stimulate the natural repair process of cells and tissues; through precise positioning, the light source of the light therapy device is directly irradiated to the specific area of ​​the brain of the Alzheimer's patient, improving the accuracy and effect of the treatment; the light therapy device is equipped with a temperature control device, which can monitor and control the temperature of the treatment area in real time to ensure the safety and reliability of the treatment. The light therapy device is based on the principle of non-invasive phototherapy and can avoid the side effects and complications that may be caused by traditional treatment methods. Compared with the traditional continuous lighting method, the thermal effect of LED light emission is greatly reduced, thereby reducing damage to the skin during the irradiation process. To ensure the safety of the treatment process, a temperature sensor is integrated to help monitor and control the temperature of the treatment area to avoid potential risks and side effects.

[0020] In summary, the LED Alzheimer's light therapy device based on intense pulsed light of the utility model has flexible and adjustable lighting parameters, can provide personalized treatment according to the specific needs of different Alzheimer's patients, stimulate the growth of neurons and restore their functions. At the same time, the stability and durability of the light therapy device are effectively guaranteed, and it has practical clinical application value. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural diagram of an LED Alzheimer's disease phototherapy device (irradiation head) using intense pulsed light according to the utility model.

[0022] Figure 2 It is a diagram of the LED light source module of the LED Alzheimer's disease phototherapy device with intense pulsed light of the present invention.

[0023] Figure 3 This is the external structure diagram of the driving part of the irradiation head of the LED Alzheimer's disease phototherapy device with intense pulsed light of the utility model.

[0024] Figure 4 It is a schematic diagram of a step-down circuit and a driving circuit in a control module of an LED Alzheimer's disease phototherapy device with intense pulsed light of the utility model.

[0025] Numbers in the figure: 1 is the LED Alzheimer's light therapy device irradiation head, 2 is the LED light source module, 3 is the LED array, 4 is the flexible circuit substrate, 5 is the flexible shell, 6 is the temperature sensor, 7 is the LED heat dissipation fence, 8 is the irradiation head power line, 9 is the connecting plug, 10 is the headband, 11 is the via hole, 12 is the fixing hole, 13 is the reflective film, 14 is the diffusion plate, 15 is the interactive module, 16 is the power cord, 17 is the power supply module, 18 is the switch, 19 is the output socket, 20 is a large-capacity electrolytic capacitor, 21 is two field-effect transistors, 22 is a six-way inverter, and 23 is a gate driver. DETAILED DESCRIPTION

[0026] The technical solution of the utility model will be further described below in conjunction with embodiments and drawings.

[0027] The utility model provides an LED light therapy device for alleviating Alzheimer's disease based on an intense pulsed light system, which is composed of an LED light source module, a drive module, a control module, a flexible housing and a heat dissipation module. Figure 1 The external structure of the intense pulsed light LED Alzheimer's light therapy device head includes an LED Alzheimer's light therapy device head 1, an LED light source module 2, an LED array 3, a flexible circuit substrate 4, a flexible shell 5, a temperature sensor 6, an LED heat dissipation fence 7, an irradiation head power line 8, a connecting plug 9, and a headband 10. The LED light source module is shown in FIG. Figure 2 As shown, it includes an LED array 3, a flexible circuit substrate 4, a through hole 11, fixing holes 12, 13, a reflective film 13, and a diffuser 14. The LED array consists of 35 LED lamp beads, and the number and arrangement of the LED lamps adopt five parallel and seven series. The peak wavelength of the LED chip is preferably between the red light and infrared light bands, that is, 630-1000nm, preferably 630nm and 660nm. The center vertical lines of the LED array 3, the flexible circuit substrate 4, the reflective film 13, and the diffuser 14 are on the same straight line. The flexible circuit substrate 4 is connected to the control module. The LED array 3 and the reflective film 13 are fixedly placed on one side of the flexible circuit substrate 4. The reflective film 13 faces the diffuser 14 side to enhance the reflection effect of light and improve the focusing degree and penetration ability of light.

[0028] The flexible circuit substrate 4 independently drives each LED array 3 with constant current and performs PWM dimming. The PWM dimming has an amplitude setting range of 1-48V, a duty cycle of 0.01%-50%, and a frequency range of 0.2Hz-20KHz. The output PWM signal has an amplitude range of 1-48V, a PWM frequency range of 0.2Hz-20KH, and a duty cycle of 0.01%-50%.

[0029] See the external structure of the drive part Figure 3As shown, the front panel is provided with an interactive module 15, a switch 18, a power cord 16, a power supply module 17, an output socket 19, etc. The interactive module 15 is used to realize the input of information and the display and output of the system working status. Figure 4 , according to the input control pulse driving circuit output corresponding electric drive, thereby lighting up the LED array 3.

[0030] When using the LED phototherapy device of the present intense pulsed light to alleviate Alzheimer's disease, a 630nm LED light source is selected, and the pulse parameters are an amplitude of 50V, a pulse width of 10us, a duty cycle of 0.01%, a period of 10ms, a frequency of 40Hz, and a peak optical power density of 360W / cm 2 ,The phototherapy time is 20 minutes. Place the device on the patient's forehead, close but not squeezing, and turn on the phototherapy.

[0031] In summary, this LED Alzheimer's light therapy device based on intense pulsed light improves the brain cell function of Alzheimer's patients through the intense pulsed light stimulation of the LED array, and promotes their rehabilitation and treatment effects. It is characterized by high intensity, high frequency and short pulse width, which can directly act on brain cells, improve the metabolic level of cells, enhance communication and connection between cells, and activate and improve their functions. At the same time, through flexible control modules, personalized light therapy treatment plans can be realized to provide patients with more accurate and effective treatment. Through long-term light therapy treatment, the patient's memory, cognition and behavioral functions can be improved.

Claims

1. An LED Alzheimer's disease phototherapy device based on intense pulsed light, characterized in that: Specifically, it includes an LED light source module, a driving module, a control module, a flexible housing and a heat dissipation module; the LED light source module, the driving module, the control module and the flexible housing are integrated and assembled into an irradiation head of a light therapy device; wherein: The LED light source module is composed of an LED array, a flexible circuit substrate, a reflective film, a flexible shell and a headband; wherein the LED array is arranged on the front of the flexible circuit substrate, the flexible shell is fixed on the front of the flexible circuit substrate to isolate the patient's scalp and the LED array, the reflective film is arranged on the flexible circuit substrate to enhance the reflection effect of light; the headband is arranged on the flexible shell to fix it so that the flexible shell fits the affected area; The LED array is used to generate light with a peak wavelength between the red light and infrared light bands, i.e., 630-1000 nm, which directly acts on damaged neurons; The driving module provides stable power drive for the LED light source module to ensure the normal operation of the LED light source module and the stability of the phototherapy effect; The control module adjusts the light intensity, light mode and light time of the LED light source module according to the condition of the Alzheimer's patient to maximize the stimulation of neuron growth and regeneration, is suitable for different treatment stages and disease changes, promotes the recovery of the lesion area, and achieves the best treatment effect; The flexible shell has a certain curvature to conform to the curve of the human head; The heat dissipation module, specifically an LED heat dissipation fence, is arranged outside the irradiation head to dissipate the heat generated by the phototherapy device, keep the temperature of the device within a safe range, and avoid adverse effects on patients due to overheating.

2. The LED Alzheimer's disease light therapy device according to claim 1, characterized in that: The LED array is arranged on the front side of the flexible circuit substrate in a five-parallel and seven-series manner; the flexible circuit board is provided with four fixing holes for fixing the LED array.

3. The LED Alzheimer's disease light therapy device according to claim 1, characterized in that: The PWM dimming control mode is adopted, the duty cycle is controlled at 0.01%-50%, and the control frequency range is 0.2Hz-20KHz.

4. The LED Alzheimer's disease light therapy device according to claim 1, characterized in that: The control module provides a stable power supply for the single-chip microcomputer and the driving module through two step-down circuits; the single-chip microcomputer receives the user's key signals and generates corresponding control signals; these control signals are transmitted to the driving module through six inverters to adjust the working state of the LED array, such as the light therapy intensity and pulse frequency; by changing the duty cycle and frequency of the PWM signal, the LED array can emit light of different intensities and frequencies to achieve the light therapy effect for Alzheimer's disease.

5. The LED Alzheimer's disease light therapy device according to any one of claims 1 to 4, characterized in that: The LED light source module is also equipped with a temperature monitoring device to monitor the patient's skin temperature in real time to ensure a safe and comfortable treatment process.

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