Salting device for preparing ursodesoxycholic acid

Abstract

The utility model discloses a salifying device for preparing ursodesoxycholic acid, which comprises a base plate, a filter and a mounting frame are fixedly connected to the upper end of the base plate, a reaction kettle is fixedly connected to the upper end of the filter, a heater is fixedly connected in the mounting frame, and the heater is fixedly connected with the reaction kettle through a heat conduction pipe. And the upper end of the mounting frame is fixedly connected with a limiting ring. A pressurizing mechanism is formed by a mounting frame, a limiting ring, a hydraulic machine, a hydraulic rod, a pressurizing plate, a pressurizing chamber, a pressurizing pipe and a reaction kettle, the hydraulic machine upwards presses the pressurizing plate through the hydraulic rod so as to compress the pressurizing chamber, and the pressurizing chamber pressurizes the reaction kettle through the pressurizing pipe so as to improve the reaction rate, so that ursodesoxycholate can be quickly prepared; the preparation efficiency of the device is improved; the filter, the guide pipe, the liquid pump, the drying box and the collecting box are combined to form a reaction post-treatment mechanism, ursodesoxycholate can be quickly filtered, dried, crystallized and collected, and the functionality of the device is enhanced.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical preparation, in particular to a salt-forming device for preparing ursodeoxycholic acid. Background Art

[0002] The existing ursodeoxycholic acid salt-forming device for preparing ursodeoxycholic acid takes a long time to prepare ursodeoxycholic acid salt, the reaction preparation rate of the device is not high, the efficiency of the device is not high, which is not conducive to the rapid production of ursodeoxycholic acid salt; the device has insufficient processing procedures for ursodeoxycholic acid salt, the process is imperfect, which is not conducive to the collection of ursodeoxycholic acid salt, and the device is not convenient to use. A Chinese patent discloses a "ursodeoxycholic acid salt-forming concentration tank", whose application number is "CN201920477290.7", which includes a tank body, a feed pipe is provided on one side of the tank body, a heating ring is provided on the inner wall of the tank body, and a high-pressure concentration mechanism is provided on the top of the heating ring; the high-pressure concentration mechanism includes a primary filter screen, a guide shell is provided on the top of the primary filter screen, the cross-sectional shape of the guide shell is set to be funnel-shaped, a cooling shell is provided on the top of the guide shell, a condensation chamber is provided inside the cooling shell, a condensation tube is provided inside the condensation chamber, and the condensation tube runs through the tank body and extends to the outside. The utility model is provided with a high-pressure concentration mechanism. After the material is vaporized inside the concentration box, it is filtered at the molecular level through a reverse osmosis filter membrane under the action of pressure. The filtered water vapor is discharged through the air outlet pipe, and the liquid outlet pipe conveys the condensed material, which effectively improves the quality of concentration, ensures the qualified rate of the concentrated material, and improves the concentration effect. However, the preparation rate of the device is limited, the reaction time is long, which is not conducive to rapid production; the processing procedures and processes of the device are imperfect, which is not conducive to the collection of ursodeoxycholate. Utility Model Content

[0003] The utility model aims to solve at least one of the technical problems existing in the prior art, and provides a salt-forming device for preparing ursodeoxycholic acid. A pressurizing mechanism is formed by a mounting frame, a limit ring, a hydraulic press, a hydraulic rod, a pressurizing plate, a pressurizing chamber, a pressurizing tube and a reactor. The hydraulic press presses the pressurizing plate through the hydraulic rod to compress the pressurizing chamber, and the pressurizing chamber presses the reactor through the pressurizing tube to increase the reaction rate, which is beneficial to the rapid preparation of ursodeoxycholic acid salt, and the preparation efficiency of the device is improved; a post-reaction processing mechanism is formed by the combination of a filter, a conduit, a liquid pump, a drying box and a collecting box, and ursodeoxycholic acid salt can be quickly filtered, dried, crystallized and collected, and the functionality of the device is enhanced.

[0004] The utility model also provides a salt-forming device for preparing ursodeoxycholic acid, comprising: a base plate, the upper end of the base plate is fixedly connected with a filter and a mounting frame, the upper end of the filter is fixedly connected with a reactor, a heater is fixedly connected inside the mounting frame, the heater is fixedly connected with the reactor through a heat-conducting pipe, and the upper end of the mounting frame is fixedly connected with a limiting ring; a hydraulic press, the lower end of the hydraulic press is sleeved with the limiting ring, the upper end of the hydraulic press is fixedly connected with a pressurizing chamber, the upper end of the hydraulic press is fixedly connected with a pressurizing plate through a hydraulic rod, the pressurizing plate is located inside the pressurizing chamber, and the upper end of the pressurizing chamber is fixedly connected with the upper end of the reactor through a pressurizing pipe.

[0005] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the lower end of the base plate is fixedly connected with a roller to improve the flexibility of the device. The roller is located at the four corners of the lower end of the base plate to make the device stable.

[0006] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with an ursodeoxycholic acid tank, a sodium hydroxide tank and an ethanol tank, which is conducive to the rapid provision of raw materials. The upper end of the ursodeoxycholic acid tank is provided with a first feeding hopper, which is conducive to the rapid replenishment of raw materials. The upper end of the sodium hydroxide tank is provided with a second feeding hopper, which is conducive to the rapid replenishment of raw materials. The upper end of the ethanol tank is provided with a third feeding hopper, which is conducive to the rapid replenishment of raw materials.

[0007] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with a first liquid pump to improve the convenience of raw material transportation. The input end of the first liquid pump is fixedly connected to the ursodeoxycholic acid tank through a first conduit to facilitate the transportation of raw materials. The output end of the first liquid pump is fixedly connected to the reactor through a second conduit to facilitate the transportation of raw materials.

[0008] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with a second liquid pump to improve the convenience of raw material transportation. The input end of the second liquid pump is fixedly connected to the sodium hydroxide tank through the third conduit to facilitate the transportation of raw materials. The output end of the second liquid pump is fixedly connected to the reactor through the fourth conduit to facilitate the transportation of raw materials.

[0009] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with a third liquid pump to improve the convenience of raw material transportation. The input end of the third liquid pump is fixedly connected to the ethanol tank through the fifth conduit to facilitate the transportation of the raw materials. The output end of the third liquid pump is fixedly connected to the reactor through the sixth conduit to facilitate the transportation of the raw materials.

[0010] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with a drying box, which is conducive to the rapid crystallization and drying of ursodeoxycholic acid salt. The drying box is slidably connected with a collection box to improve the convenience of collection.

[0011] According to the salt-forming device for preparing ursodeoxycholic acid described in the utility model, the upper end of the substrate is fixedly connected with a fourth liquid pump to improve the convenience of product delivery. The input end of the fourth liquid pump is fixedly connected to the filter through the seventh conduit to facilitate the delivery of the product. The output end of the fourth liquid pump is fixedly connected to the drying box through the eighth conduit to facilitate the delivery of the product.

[0012] Beneficial Effects

[0013] 1. Compared with the prior art, the salt-forming device for preparing ursodeoxycholic acid forms a pressurizing mechanism through a mounting frame, a limiting ring, a hydraulic press, a hydraulic rod, a pressurizing plate, a pressurizing chamber, a pressurizing tube and a reactor. The hydraulic press presses the pressurizing plate through the hydraulic rod to compress the pressurizing chamber, and the pressurizing chamber presses the reactor through the pressurizing tube to increase the reaction rate, which is beneficial to the rapid preparation of ursodeoxycholic acid salt, and the preparation efficiency of the device is improved;

[0014] 2. Compared with the prior art, the salt-forming device for preparing ursodeoxycholic acid forms a post-reaction processing mechanism through the combination of a filter, a catheter, a liquid pump, a drying box and a collection box, which can quickly filter, dry, crystallize and collect ursodeoxycholic acid salt, and the functionality of the device is enhanced. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The utility model is further described below in conjunction with the accompanying drawings and embodiments;

[0016] Figure 1 This is a schematic structural diagram of a salt-forming device for preparing ursodeoxycholic acid according to the utility model;

[0017] Figure 2 This is a schematic structural diagram of a collection box of a salt-forming device for preparing ursodeoxycholic acid in the utility model in a retracted state;

[0018] Figure 3 This is a schematic diagram of the transverse cross-sectional structure of a salt-forming device for preparing ursodeoxycholic acid according to the utility model;

[0019] Figure 4 The utility model is a schematic diagram of the longitudinal cross-sectional structure of a salt-forming device for preparing ursodeoxycholic acid.

[0020] Legend:

[0021] 1. substrate; 2. fifth conduit; 3. roller; 4. first conduit; 5. ethanol tank; 6. third hopper; 7. sodium hydroxide tank; 8. second hopper; 9. ursodeoxycholic acid tank; 10. first hopper; 11. sixth conduit; 12. fourth conduit; 13. second conduit; 14. hydraulic press; 15. pressure plate; 16. hydraulic rod; 17. pressure chamber; 18. limit ring; 19. mounting frame; 20. heater; 21. pressure pipe; 22. heat pipe; 23. drying box; 24. collecting box; 25. reactor; 26. eighth conduit; 27. fourth liquid pump; 28. seventh conduit; 29. ​​filter; 30. first liquid pump; 31. second liquid pump; 32. third liquid pump; 33. third conduit. DETAILED DESCRIPTION

[0022] This section will describe in detail the specific embodiments of the utility model. The preferred embodiments of the utility model are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the utility model, but it cannot be understood as a limitation on the protection scope of the utility model.

[0023] Reference Figure 1-4The utility model embodiment is a salt-forming device for preparing ursodeoxycholic acid, which includes: a substrate 1, the lower end of the substrate 1 is fixedly connected to a roller 3 for movement, the roller 3 is located at the four corners of the lower end of the substrate 1 for balance, the upper end of the substrate 1 is fixedly connected to a filter 29 and a mounting frame 19 for filtering the generated ursodeoxycholic acid salt, the upper end of the filter 29 is fixedly connected to a reactor 25 for reaction to generate ursodeoxycholic acid salt, a heater 20 is fixedly connected inside the mounting frame 19 to provide high temperature for the reaction, the heater 20 is fixedly connected to the reactor 25 through a heat pipe 22 to form a heat conduction structure, and the mounting frame 19 The upper end of the substrate 1 is fixedly connected with a limiting ring 18 for limiting. The upper end of the substrate 1 is fixedly connected with an ursodeoxycholic acid tank 9, a sodium hydroxide tank 7 and an ethanol tank 5 to store the raw materials required for preparation. The upper end of the ursodeoxycholic acid tank 9 is provided with a first feeding hopper 10 to replenish ursodeoxycholic acid. The upper end of the sodium hydroxide tank 7 is provided with a second feeding hopper 8 to replenish sodium hydroxide. The upper end of the ethanol tank 5 is provided with a third feeding hopper 6 to replenish ethanol. The upper end of the substrate 1 is fixedly connected with a first liquid pump 30 to provide power for the transportation of raw materials. The input end of the first liquid pump 30 is fixedly connected to the ursodeoxycholic acid tank 9 through a first conduit 4 to form a transportation structure. The output end of the liquid pump 30 is fixedly connected to the reactor 25 through the second conduit 13 to form a conveying structure. The upper end of the substrate 1 is fixedly connected to the second liquid pump 31 to provide power for the delivery of the raw materials. The input end of the second liquid pump 31 is fixedly connected to the sodium hydroxide tank 7 through the third conduit 33 to form a conveying structure. The output end of the second liquid pump 31 is fixedly connected to the reactor 25 through the fourth conduit 12 to form a conveying structure. The upper end of the substrate 1 is fixedly connected to the third liquid pump 32 to provide power for the delivery of the raw materials. The input end of the third liquid pump 32 is fixedly connected to the ethanol tank 5 through the fifth conduit 2 to form a conveying structure. The output end of the third liquid pump 32 is fixedly connected to the reactor 25 through the sixth conduit 11 to form a conveying structure. The upper end of the substrate 1 is fixedly connected to a drying box 23 to crystallize and dry ursodeoxycholate. A collecting box 24 is slidably connected in the drying box 23 to collect ursodeoxycholate. The upper end of the substrate 1 is fixedly connected to a fourth liquid pump 27 to provide power for the delivery of ursodeoxycholate. The input end of the fourth liquid pump 27 is fixedly connected to the filter 29 through the seventh conduit 28 to form a conveying structure. The output end of the fourth liquid pump 27 is fixedly connected to the drying box 23 through the eighth conduit 26 to form a conveying structure.

[0024] The hydraulic press 14 has its lower end sleeved with a limit ring 18 to form a compact structure. The upper end of the hydraulic press 14 is fixedly connected to a pressurized chamber 17 to form a pressurized environment. The upper end of the hydraulic press 14 is fixedly connected to a pressurized plate 15 through a hydraulic rod 16 to squeeze the space in the pressurized chamber. The pressurized plate 15 is located inside the pressurized chamber 17 to form a pressurized layout. The upper end of the pressurized chamber 17 is fixedly connected to the upper end of the reactor 25 through a pressurized pipe 21 to form a pressurized structure.

[0025] Working principle: Ursodeoxycholic acid salt is prepared by using a salt-forming device for preparing ursodeoxycholic acid. Ursodeoxycholic acid is transported to the reactor 25 through the first conduit 4, the first liquid pump 30 and the second conduit 13. Sodium hydroxide is transported to the reactor 25 through the third conduit 33, the second liquid pump 31 and the fourth conduit 12. Ethanol is transported to the reactor 25 through the fifth conduit 2, the third liquid pump 32 and the sixth conduit 11. The heater 20 provides high temperature for the reactor 25 through the heat pipe 22. The hydraulic press 14 is connected to the reactor 25 through the hydraulic rod 16. The pressure plate 15 is pressed upward to compress the pressure chamber 17. The pressure chamber 17 pressurizes the reactor 25 through the pressure pipe 21. Ursodeoxycholic acid, sodium hydroxide and ethanol react in the reactor to generate ursodeoxycholate. The generated ursodeoxycholate is filtered in the filter 29. After filtering, the ursodeoxycholate is transported to the drying box 23 through the seventh conduit 28, the fourth liquid pump 27 and the eighth conduit 26. The drying box 23 crystallizes and dries the ursodeoxycholate, and the collection box 24 collects the ursodeoxycholate.

[0026] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A salt-forming device for preparing ursodeoxycholic acid, characterized in that: include: A substrate (1), the upper end of the substrate (1) being fixedly connected to a filter (29) and a mounting frame (19), the upper end of the filter (29) being fixedly connected to a reaction kettle (25), a heater (20) being fixedly connected inside the mounting frame (19), the heater (20) being fixedly connected to the reaction kettle (25) via a heat conducting pipe (22), and a limiting ring (18) being fixedly connected to the upper end of the mounting frame (19); A hydraulic press (14), wherein the lower end of the hydraulic press (14) is sleeved with a limit ring (18), the upper end of the hydraulic press (14) is fixedly connected to a pressurizing chamber (17), the upper end of the hydraulic press (14) is fixedly connected to a pressurizing plate (15) via a hydraulic rod (16), the pressurizing plate (15) is located inside the pressurizing chamber (17), and the upper end of the pressurizing chamber (17) is fixedly connected to the upper end of a reaction kettle (25) via a pressurizing pipe (21).

2. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: The lower end of the base plate (1) is fixedly connected to a roller (3), and the roller (3) is located at the four corners of the lower end of the base plate (1).

3. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: An ursodeoxycholic acid tank (9), a sodium hydroxide tank (7) and an ethanol tank (5) are fixedly connected to the upper end of the base plate (1); a first feeding hopper (10) is arranged at the upper end of the ursodeoxycholic acid tank (9); a second feeding hopper (8) is arranged at the upper end of the sodium hydroxide tank (7); and a third feeding hopper (6) is arranged at the upper end of the ethanol tank (5).

4. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: A first liquid pump (30) is fixedly connected to the upper end of the substrate (1); an input end of the first liquid pump (30) is fixedly connected to an ursodeoxycholic acid tank (9) via a first conduit (4); and an output end of the first liquid pump (30) is fixedly connected to a reaction kettle (25) via a second conduit (13).

5. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: A second liquid pump (31) is fixedly connected to the upper end of the substrate (1); an input end of the second liquid pump (31) is fixedly connected to a sodium hydroxide tank (7) via a third conduit (33); and an output end of the second liquid pump (31) is fixedly connected to a reaction kettle (25) via a fourth conduit (12).

6. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: A third liquid pump (32) is fixedly connected to the upper end of the substrate (1); an input end of the third liquid pump (32) is fixedly connected to an ethanol tank (5) via a fifth conduit (2); and an output end of the third liquid pump (32) is fixedly connected to a reaction kettle (25) via a sixth conduit (11).

7. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: A drying box (23) is fixedly connected to the upper end of the base plate (1), and a collecting box (24) is slidably connected inside the drying box (23).

8. The salt-forming device for preparing ursodeoxycholic acid according to claim 1, characterized in that: A fourth liquid pump (27) is fixedly connected to the upper end of the substrate (1); an input end of the fourth liquid pump (27) is fixedly connected to a filter (29) via a seventh conduit (28); and an output end of the fourth liquid pump (27) is fixedly connected to a drying box (23) via an eighth conduit (26).

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