Mobile phase preparation device

Abstract

The utility model discloses a mobile phase preparation device which comprises a cabinet type body, and a partition plate is mounted on the cabinet type body to divide the cabinet type body into at least an upper part and a lower part; a reaction kettle, a first peristaltic pump and a multi-shaft mechanical arm are mounted in the cabinet type body, and the reaction kettle is mounted on the bottom surface of the cabinet type body, is communicated with a raw material tank and is used for mixing raw materials to form a mobile phase; the first peristaltic pump is mounted on the partition plate, is adjacent to the reaction kettle and is used for conveying a mixed mobile phase in the reaction kettle into the mobile phase bottle through a canning device; the multi-axis mechanical arm is mounted on the bottom surface of the cabinet type body and is used for controlling the mobile phase bottle to move. According to the mobile phase preparation device provided by the utility model, the automatic preparation of the mobile phase is realized, the difference between batches is effectively reduced, and when centralized preparation is needed, the preparation time is short, and the preparation efficiency is high.

Description

Technical Field

[0001] The utility model relates to the field of mobile phase preparation, in particular to a mobile phase preparation device. Background Art

[0002] High-Performance Liquid Chromatography (HPLC) is an analytical chemistry technique that is widely used in biochemistry, pharmacy, environmental science, food analysis and other fields because of its ability to effectively separate, identify and determine compound components. The mobile phase is an important component of the HPLC analysis process. It refers to the solvent or solution flowing in the HPLC column, which can carry the sample into the column for separation; therefore, the choice of mobile phase will play an important role in the analysis results. At the same time, the quality of the mobile phase and the consistency between batches also determine the stability of the analysis results.

[0003] At present, manual preparation of mobile phase is still the mainstream practice in laboratories, but manual preparation often has the following disadvantages:

[0004] Poor precision: Since the operation depends on manual labor, manual preparation is difficult to ensure the accuracy and repeatability of the mobile phase;

[0005] Time-consuming: Manual operation may take more time, especially when analyzing a large number of samples;

[0006] Toxicity hazard: The organic solvents and some additives involved in the mobile phase are often toxic and corrosive. Long-term exposure may have a certain impact on the health of operators. Utility Model Content

[0007] The technical problem to be solved by the utility model is to provide a mobile phase preparation device, which can realize the automatic preparation of the mobile phase, reduce the differences caused by manual operation, shorten the time of centralized preparation, improve the preparation efficiency, and avoid potential safety hazards to operators.

[0008] In order to solve the above technical problems, the mobile phase preparation device provided by the utility model comprises a cabinet body, wherein the cabinet body is provided with a partition plate to divide the cabinet body into at least two parts, an upper part and a lower part;

[0009] The cabinet body is equipped with:

[0010] A reaction kettle, which is installed on the bottom surface of the cabinet body, is connected to the raw material tank, and is used to mix the raw materials to form a mobile phase;

[0011] A first peristaltic pump is installed on the partition and adjacent to the reactor, and is used to transport the mixed mobile phase in the reactor to the mobile phase bottle through a canning device;

[0012] A multi-axis mechanical arm is installed on the bottom surface of the cabinet body and is used to control the movement of the mobile phase bottle.

[0013] Preferably, a second peristaltic pump is installed between the reaction kettle and the raw material tank for conveying the raw materials in the raw material tank to the reaction kettle.

[0014] Preferably, a material rack is provided adjacent to the cabinet body, and the raw material tank is placed on the material rack;

[0015] The second peristaltic pump is installed on the material rack or the partition.

[0016] Preferably, the partition is equipped with an ultrasonic component for ultrasonically treating the mobile phase after being filled in the mobile phase bottle;

[0017] The ultrasonic assembly includes a basin containing an ultrasonic medium.

[0018] Preferably, the partition is equipped with a dryer for drying the outer wall of the mobile phase bottle after ultrasonic treatment.

[0019] Preferably, the partition is equipped with a switch cover assembly for removing the bottle cap of the mobile phase bottle from the bottle mouth or covering the bottle mouth.

[0020] Preferably, the multi-axis robot arm comprises a column, a one-section arm, a two-section arm and a three-section arm;

[0021] The column is rotatably mounted on the bottom surface of the cabinet body through a base;

[0022] The one-section arm is installed on the column and extends in an axial direction perpendicular to the column, and the one-section arm can slide in the axial direction of the column;

[0023] The second arm is installed at one end of the first arm away from the column, the second arm extends along an axial direction perpendicular to the column, and the second arm rotates around the connection with the first arm in a plane perpendicular to the axial direction of the column.

[0024] The three-section arm is installed at one end of the two-section arm away from the one-section arm, the three-section arm extends along an axial direction perpendicular to the column, and the three-section arm rotates around the connection with the two-section arm in a plane perpendicular to the axial direction of the column;

[0025] The three-section arm is equipped with a clamping claw for clamping a mobile phase bottle.

[0026] Preferably, the partition is provided with a temporary storage area for mobile phase bottles.

[0027] Preferably, a waste liquid collection bucket is provided in the cabinet body.

[0028] The utility model provides a mobile phase preparation device to achieve automatic preparation of the mobile phase, effectively reduce the difference between batches, and when centralized preparation is required, the preparation time is short, the preparation efficiency is high, and potential safety hazards to operators are avoided. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solution of the utility model, the following briefly introduces the drawings required for use in the utility model. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0030] Figure 1 It is a schematic diagram of an embodiment of a mobile phase preparation device of the utility model;

[0031] Figure 2 It is a front view of an embodiment of a mobile phase preparation device of the utility model;

[0032] Figure 3 It is an internal top view of an embodiment of a mobile phase preparation device of the utility model;

[0033] In the figure, 1-cabinet body; 11-partition; 12-ultrasonic component; 13-dryer; 14-switch component; 111-mobile phase bottle temporary storage area; 121-trough; 2-reactor; 3-raw material tank; 31-second peristaltic pump; 4-first peristaltic pump; 5-canning device; 6-multi-axis robotic arm; 61-column; 62-first section arm; 63-second section arm; 64-third section arm; 7-material rack; 8-mobile phase bottle; 9-material cart. DETAILED DESCRIPTION

[0034] The following will be combined with the accompanying drawings to clearly and completely describe the technical solutions in the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0035] refer to Figure 1-3 , shows a mobile phase preparation device of the utility model, comprising: a cabinet body, the cabinet body is equipped with a partition to divide the cabinet body into at least two parts, an upper part and a lower part;

[0036] The cabinet body is equipped with:

[0037] A reaction kettle, which is installed on the bottom surface of the cabinet body, is connected to the raw material tank, and is used to mix the raw materials to form a mobile phase;

[0038] A first peristaltic pump is installed on the partition and adjacent to the reactor, and is used to transport the mixed mobile phase in the reactor to the mobile phase bottle through a canning device;

[0039] A multi-axis mechanical arm is installed on the bottom surface of the cabinet body and is used to control the movement of the mobile phase bottle.

[0040] In the embodiment of the utility model, the reactor, the first peristaltic pump and the multi-axis robotic arm are integrated into a cabinet body. After the raw materials complete the reaction in the reactor to form a mobile phase, they are filled into a plurality of mobile phase bottles through a canning device under the action of the first peristaltic pump, and the multi-axis robotic arm then carries out transportation and processing of the mobile phase bottles. It can be understood that the utility model also includes a controller, and the controller is connected to the reactor, the multi-axis robotic arm, the first peristaltic pump, the canning device and other components by signal connection. The controller controls the peristaltic pump to start and stop working, controls the stirring of the reactor and other operations, and controls the canning device to start or stop working. Filling the mobile phase into the mobile phase bottle and transporting the mobile phase bottle by controlling the multi-axis robot arm through the controller can be achieved by the existing technology, and will not be described in detail in this embodiment; the utility model can be achieved by the operator operating the controller, and the mobile phase preparation process is realized through an automated program, which effectively reduces the differences between different batches caused by different operating techniques during manual preparation; and during centralized preparation, the preparation efficiency is higher, which effectively reduces the labor cost, and because the operator does not directly contact the raw materials and the mobile phase during the operation, the safety hazards caused by the toxicity of the materials to the operator can be avoided as much as possible.

[0041] In a specific embodiment, a second peristaltic pump is installed between the reactor and the raw material tank for conveying the raw material in the raw material tank to the reactor. It is understandable that by adding a second peristaltic pump, the raw material can be more accurately and efficiently conveyed to the reactor, saving manpower and cost, and avoiding direct contact of the operator with the raw material. It should be noted that the raw materials of the mobile phase mainly include pure water (from a pure water instrument) and / or an organic solvent. Generally, each organic solvent needs to be provided with a corresponding peristaltic pump. Therefore, the second peristaltic pump here is generally multiple to correspond to different types of organic solvents.

[0042] In a specific embodiment, a material rack is provided adjacent to the cabinet body, and the raw material tank is placed on the material rack; the second peristaltic pump is installed on the material rack or the partition. Understandably, before preparing the mobile phase, the required materials need to be prepared, and a material rack is added around the cabinet body, and the raw material tank containing the materials is temporarily stored on the material rack, which is more convenient for direct use of the materials and reduces frequent handling; in addition, if it is not desired to be constrained by this, the raw material tank can also be temporarily stored in the lower part of the cabinet body (i.e., the part under the partition), but due to the limited space in the lower part, the number of raw material tanks temporarily stored therein is limited.

[0043] In a specific embodiment, the partition is equipped with an ultrasonic component for ultrasonically treating the mobile phase after being filled in the mobile phase bottle; the ultrasonic component includes a trough, and the trough contains an ultrasonic medium. It is understandable that the filled mobile phase needs to be ultrasonically degassed, and the ultrasonic component is integrated into the preparation device of the utility model, and the filled mobile phase bottle is transported to the trough by a multi-axis robotic arm. The opening and closing of the ultrasonic component is preferably controlled by a controller, and the ultrasonic time can also be set by the controller. After the ultrasonic reaches the target time, the robotic arm transports the mobile phase bottle away from the trough; preferably, the trough can accommodate multiple mobile phase bottles at one time. During the preparation of the mobile phase, the ultrasonic component is always in an ultrasonically open state, so as to realize the streamlined operation of ultrasonic degassing of the mobile phase; it is understandable that the ultrasonic component also includes at least an ultrasonic transducer for generating ultrasonic waves. Since the combination of the ultrasonic transducer and the trough is a prior art, it will not be repeated here.

[0044] In a specific embodiment, the partition is equipped with a dryer for drying the outer wall of the mobile phase bottle after ultrasonic treatment. Understandably, after the ultrasonic degassing is completed, liquid will remain on the outer wall of the mobile phase bottle, so it needs to be dried. Understandably, the dryer can be configured to have multiple accommodating chambers, each of which can accommodate a mobile phase bottle and dry it, which can effectively improve the drying efficiency; the inner wall of each accommodating chamber can preferably be configured as a woven fabric with strong hygroscopicity to absorb moisture from the outer wall; or the inner wall of the accommodating chamber is provided with a jet nozzle of compressed dry air to air-dry the outer wall, and the bottom surface of the accommodating chamber is provided with a vacuum adsorption component to vacuum absorb the residual liquid blown off the outer wall of the mobile phase bottle during air drying. It is not desired to be constrained by this, and other mobile phase bottle outer wall drying methods in the prior art can be applied to the utility model.

[0045] In a specific embodiment, the partition is equipped with a switch cover assembly for removing the bottle cap of the mobile phase bottle from the bottle mouth or covering the bottle mouth. It can be understood that the bottle mouth of the mobile phase bottle is usually covered with a bottle cap. In order to save time and labor costs for manually opening the bottle cap, the present application preferably adds a switch cover assembly to open the bottle cap or cover the bottle cap on the mobile phase bottle, and more preferably controls the switch cover assembly through a controller. For example, the switch cover assembly includes a bottle bottom fastening mechanism and a bottle cap opening mechanism. When opening or covering the bottle, the bottle bottom fastening mechanism first fixes the bottle bottom, and the bottle cap opening mechanism opens or covers the bottle cap; the bottle cap fixing mechanism can be, for example, a clamp-like clamp or a similar structure, and the bottle cap opening mechanism can be set according to the way the bottle cap is set. For example, if the bottle cap is set on the bottle mouth of the mobile phase bottle through a threaded connection, the bottle cap opening mechanism can be set in a way that the bottle cap can be clamped and then rotated to open the cap; if the bottle cap is plugged at the bottle mouth of the mobile phase bottle, the bottle cap opening mechanism can be set in a way that the bottle cap is clamped and then a pulling force is applied to open the cap. These implementation methods can be achieved through existing technologies and will not be repeated here.

[0046] In a specific embodiment, the multi-axis robot arm includes a column, a one-section arm, a two-section arm, and a three-section arm;

[0047] The column is rotatably mounted on the bottom surface of the cabinet body through a base;

[0048] The one-section arm is installed on the column and extends in an axial direction perpendicular to the column, and the one-section arm can slide in the axial direction of the column;

[0049] The second arm is installed at one end of the first arm away from the column, the second arm extends along an axial direction perpendicular to the column, and the second arm rotates around the connection with the first arm in a plane perpendicular to the axial direction of the column.

[0050] The three-section arm is installed at one end of the two-section arm away from the one-section arm, the three-section arm extends along an axial direction perpendicular to the column, and the three-section arm rotates around the connection with the two-section arm in a plane perpendicular to the axial direction of the column;

[0051] The three-section arm is equipped with a clamp (not shown) for clamping a mobile phase bottle.

[0052] In this specific embodiment, the use of a multi-axis robotic arm can increase its flexibility and its range of motion as much as possible, so that its range of motion covers as much of the entire cabinet body as possible, especially to achieve flexible transportation of mobile phase bottles between filling, ultrasonic, drying, temporary storage and other positions. It should be noted that the multi-axis robotic arm and its working method used in the utility model can be realized by existing technologies and will not be repeated here. In the utility model, the main work of the multi-axis robotic arm includes transporting the mobile phase bottle from the temporary storage area of ​​the mobile phase bottle to the filling position, and then transporting the mobile phase bottle to the trough for ultrasonication after the filling is completed, and then transporting it to the drying position after the ultrasonication is completed, and then transporting it to the sampling position after the drying is completed; in the utility model, the sampling position can be set on the partition, or it can be a movable or immovable material table or material cart located outside the cabinet body and adjacent to the cabinet body.

[0053] In a specific embodiment, a waste liquid collection barrel (not shown) is provided in the cabinet body, for example, it is provided between its bottom surface and the partition (i.e., the lower half of the cabinet body located below the partition); it is understandable that the main purpose of the waste liquid collection barrel is to collect the first or first few cleaning liquids after the preparation of the mobile phase is completed, because it contains a large amount of residual raw materials and does not meet the standards for direct discharge. After the collection is completed, the waste liquid needs to continue to be specially treated according to regulations; preferably, for example, the partition is provided with a through hole for the waste liquid collection barrel, and the opening of the waste liquid collection barrel is arranged corresponding to the through hole. For example, after the reactor is cleaned with pure water, the cleaning liquid is filled into a container similar to the mobile phase bottle through a canning device under the action of a first peristaltic pump, and the multi-axis robotic arm then transports the container to the through hole position, and pours the cleaning liquid from the through hole into the waste liquid collection barrel as much as possible. The cleaning can be performed multiple times, and the cleaning liquid can be poured into the waste liquid collection barrel, or only the first or first few times can be poured into the waste liquid collection barrel according to actual conditions.

[0054] The working process of preparing the mobile phase using the mobile phase preparation device of the utility model is as follows:

[0055] The first step is to prepare the materials according to the raw materials required for the mobile phase;

[0056] The second step is to place the feed port of the second peristaltic pump in the material tank, the discharge port in the reactor, and start the second peristaltic pump to transport the material into the reactor;

[0057] In the third step, the multi-axis robot arm transports the mobile phase bottle to the bottle cap opening position, and the switch cover assembly opens the bottle cap of the mobile phase bottle;

[0058] In the fourth step, the multi-axis robot moves the mobile phase bottle from the bottle cap opening position to the filling position, and the first peristaltic pump is started to fill the mobile phase prepared in the reactor into the mobile phase bottle;

[0059] In the fifth step, the multi-axis robotic arm transports the filled mobile phase bottle to the bottle cap opening area and caps it;

[0060] Step 6: The multi-axis robotic arm moves the capped mobile phase bottle to the tank for ultrasonic degassing;

[0061] Step 7: The multi-axis robotic arm transports the debubbled mobile phase bottle to a drying position for drying.

[0062] In the eighth step, the multi-axis robotic arm transports the dried mobile phase bottle to the sampling site.

[0063] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A mobile phase preparation device, characterized in that, The cabinet body comprises a partition plate installed on the cabinet body to divide the cabinet body into at least two parts, an upper part and a lower part; The cabinet body is equipped with: A reaction kettle, which is installed on the bottom surface of the cabinet body, is connected to the raw material tank, and is used to mix the raw materials to form a mobile phase; A first peristaltic pump is installed on the partition and adjacent to the reactor, and is used to transport the mixed mobile phase in the reactor to the mobile phase bottle through a canning device; A multi-axis mechanical arm is installed on the bottom surface of the cabinet body and is used to control the movement of the mobile phase bottle.

2. The mobile phase preparation device according to claim 1, characterized in that: A second peristaltic pump is installed between the reaction kettle and the raw material tank to transport the raw materials in the raw material tank to the reaction kettle.

3. The mobile phase preparation device as claimed in claim 2, characterized in that, A material rack is provided adjacent to the cabinet body, and the raw material tank is placed on the material rack; The second peristaltic pump is installed on the material rack or the partition.

4. The mobile phase preparation device according to claim 1, characterized in that: The partition is equipped with an ultrasonic component for ultrasonically treating the mobile phase filled in the mobile phase bottle; The ultrasonic assembly includes a basin containing an ultrasonic medium.

5. The mobile phase preparation device as claimed in claim 4, characterized in that, The partition is equipped with a dryer for drying the outer wall of the mobile phase bottle after ultrasonic treatment.

6. The mobile phase preparation device according to claim 1, characterized in that, The partition is equipped with a switch cover assembly for removing the bottle cap of the mobile phase bottle from the bottle mouth or covering the bottle mouth.

7. The mobile phase preparation device according to claim 1, characterized in that, The multi-axis mechanical arm comprises a column, a first-section arm, a second-section arm and a third-section arm; The column is rotatably mounted on the bottom surface of the cabinet body through a base; The one-section arm is installed on the column and extends in an axial direction perpendicular to the column, and the one-section arm can slide in the axial direction of the column; The second-section arm is installed at one end of the first-section arm away from the column, the second-section arm extends along an axial direction perpendicular to the column, and the second-section arm rotates around the connection with the first-section arm in a plane perpendicular to the axial direction of the column; The three-section arm is installed at one end of the two-section arm away from the one-section arm, the three-section arm extends along an axial direction perpendicular to the column, and the three-section arm rotates around the connection with the two-section arm in a plane perpendicular to the axial direction of the column; The three-section arm is equipped with a clamping claw for clamping a mobile phase bottle.

8. The mobile phase preparation device according to claim 1, characterized in that, The partition is provided with a temporary storage area for mobile phase bottles.

9. The mobile phase preparation device according to claim 1, characterized in that, A waste liquid collection bucket is arranged in the cabinet body.

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