Peripheral blood cell automatic inoculation instrument with automatic labeling function

Abstract

The utility model discloses an automatic peripheral blood cell inoculation instrument with an automatic labeling function. The automatic peripheral blood cell inoculation instrument comprises an equipment cabin, a processing flow control device, a sample processing platform, a supporting mechanism, a clamping jaw mechanical arm and a liquid adding mechanical arm, a blood collection tube sample frame, an automatic labeling device, a pipette tip support and a culture tube support are arranged on the sample treatment platform, the automatic labeling device comprises a label guiding unit and a pressing unit, and the label guiding unit guides release paper and separates labels on the release paper; and the pressing unit rolls to clamp the cell culture tube and presses and attaches the separated label to the cell culture tube. By arranging the automatic labeling device, the cell culture tubes can be pressed and labeled, automatic labeling of the cell culture tubes is achieved, bar code information of blood collection tubes and bar code information of the cell culture tubes are compared, the inoculation process is shortened, and automatic inoculation and bar code management are facilitated.

Description

Technical Field

[0001] The utility model relates to a biological sample processing instrument, in particular to an automatic peripheral blood cell inoculation instrument with automatic labeling. Background Art

[0002] The main process of chromosome karyotype analysis of peripheral blood lymphocytes includes: inoculation and culture of peripheral blood lymphocytes, cell harvesting, chromosome preparation, banding staining and karyotype analysis, etc. The inoculation process can be done manually or by automated instruments. At present, such biological sample processing instruments have initially realized the automation of sample processing.

[0003] Chinese patent CN218290939U discloses an automatic cell inoculation instrument, including an automatic opening module for blood collection tubes, an automatic liquid transfer module, a cell culture module, a HEPA filter module, an ultraviolet disinfection module and a control system; a blood collection tube sample rack, a cell culture tube support and a motion module are arranged on the work platform; the control system controls the motion module, and uses the motion module to drive the automatic opening module for blood collection tubes and the automatic liquid transfer module to respectively move the blood collection tubes on the blood collection tube sample rack, the cell culture tubes on the cell culture tube support and the pipette head in XYZ three-dimensional space and adjust the position body. The label attached to the blood collection tube is associated with the user information set by the blood collection mechanism, and the new label for the cell culture tube needs to be manually attached and traced for cell inoculation and culture. The information association between the blood collection tube and the cell culture tube is realized through the new label, which is convenient for cell inoculation and culture management. Therefore, it is necessary to affix a new label to the cell culture tube each time and then transfer it to the automatic cell inoculation instrument to scan the code and enter the information. The inoculation process is cumbersome, and it takes a lot of time to affix a new label to the cell culture tube, making it difficult to achieve high-throughput automated inoculation. Utility Model Content

[0004] In view of the problems existing in the prior art, the utility model provides an automatic peripheral blood cell inoculator with automatic labeling, which is used to solve the technical problems that the current automatic cell inoculator has low inoculation efficiency, is time-consuming to affix new labels to cell culture tubes, and cannot achieve high-throughput inoculation.

[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0006] A peripheral blood cell automatic inoculator with automatic labeling, comprising an equipment cabin, a processing flow control device, a sample processing platform, a supporting mechanism, a gripper mechanical arm and a liquid adding mechanical arm; the sample processing platform is arranged at the bottom of the inner cavity of the equipment cabin, the two ends of the supporting mechanism are connected to the equipment cabin and are located above the sample processing platform, the gripper mechanical arm and the liquid adding mechanical arm are installed on the supporting mechanism, and the processing flow control device is arranged outside the equipment cabin;

[0007] The sample processing platform is provided with a blood collection tube sample rack, an automatic labeling device, a pipette tip holder and a culture tube holder; a plurality of blood collection tubes are provided on the blood collection tube sample rack; a plurality of pipette tips are provided on the pipette tip holder; a plurality of cell culture tubes are provided on the culture tube holder; the processing flow control device is signal-connected with the gripper mechanical arm, the liquid adding mechanical arm and the automatic labeling device;

[0008] The automatic labeling device comprises a label guiding unit and a pressing unit, wherein the label guiding unit guides the release paper and separates the label on the release paper, and the pressing unit rolls and clamps the cell culture tube and presses and attaches the separated label to the cell culture tube;

[0009] The gripper robot arm is capable of moving between the blood collection tube sample rack, the automatic labeling device and the culture tube support, and the gripper robot arm sequentially scans and obtains the label bar codes of multiple blood collection tubes on the blood collection tube sample rack; the gripper robot arm clamps and transfers each cell culture tube to the pressing unit for labeling, and transfers the labeled cell culture tube from the pressing unit to the culture tube support; the gripper robot arm clamps and transfers each blood collection tube on the blood collection tube sample rack to the pressing unit, and the gripper robot arm clamps the bottle cap of the blood collection tube and rotates the blood collection tube through the pressing unit to open the bottle cap;

[0010] The liquid adding robot arm can move between the automatic labeling device, the pipette tip holder and the culture tube holder. The liquid adding robot arm absorbs a pipette tip and inserts the pipette tip into the blood collection tube on the automatic labeling device and absorbs the cell sample, and then transfers the cell sample to the cell culture tube and mixes it with the culture medium.

[0011] Furthermore, the label guide unit includes a supporting base plate, a paper roll fixing wheel, a paper feeding guide wheel, a label peeling mechanism, a paper receiving guide wheel and a paper receiving wheel; the paper roll fixing wheel, the paper feeding guide wheel, the label peeling mechanism, the paper receiving guide wheel and the paper receiving wheel are vertically fixed to the upper surface of the supporting base plate, the label peeling mechanism is arranged adjacent to the lamination unit, the paper roll fixing wheel fixes the release paper, the paper feeding guide wheel guides the release paper from the paper roll fixing wheel to the label peeling mechanism, the label peeling mechanism separates the label on the release paper, and the paper receiving guide wheel guides the release paper from the label peeling mechanism to the paper receiving wheel for recycling.

[0012] Furthermore, the pressing unit includes a mounting frame, a driving wheel, a driving motor, a clamping movable frame, a driven wheel and a clamping driving mechanism; the driving motor is mounted on the mounting frame, the driving wheel is connected to the driving motor and is rotatably mounted on the mounting frame, the clamping driving mechanism is mounted on the mounting frame, the driven wheel is rotatably mounted on the clamping movable frame, the driven wheel is arranged parallel to the driving wheel to form a space for clamping the blood collection tube, the clamping movable frame is mounted on the clamping driving mechanism, and the clamping driving mechanism drives the driven wheel of the clamping movable frame to approach or move away from the driving wheel to clamp or release the blood collection tube.

[0013] Furthermore, the mounting frame includes a bottom plate groove, a top plate and a driving wheel fixing frame, the top plate is installed on the bottom plate groove, the driving wheel fixing frame and the label guide unit are installed on the top plate, the driving motor and the clamping driving mechanism are fixed in the bottom plate groove, the top plate is respectively provided with a shaft hole and a sliding hole corresponding to the driving motor and the clamping driving mechanism, the shaft of the driving motor passes through the shaft hole and is connected to the bottom end of the driving wheel, and the driving wheel fixing frame is rotatably connected to the top end of the driving wheel; the clamping driving mechanism passes through the sliding hole, the bottom end of the clamping driving mechanism is connected to the clamping driving mechanism, and at least two driven wheels are provided at the top end of the clamping driving mechanism corresponding to the driving wheel.

[0014] Furthermore, the clamping drive mechanism includes a slide plate, a horizontal push motor and a slider, the slide plate is fixed in the bottom plate groove, the slider can slide to the slide groove set on the slide plate, the horizontal push motor drives the slider to slide in the slide groove of the slide plate, the bottom end of the clamping movable frame is connected to the slider through the sliding hole, the top of the clamping movable frame is provided with a U-shaped portion, the U-shaped portion is provided with at least two driven wheels, the blood collection tube is clamped between the two driven wheels and the driving wheel, and the blood collection tube rotates with the driving wheel to press and attach the separated label to the blood collection tube.

[0015] Furthermore, the clamping robot arm includes a first three-dimensional motion mechanism, a blood collection tube automatic barcode entry module and a blood collection tube clamping module, the blood collection tube clamping module is installed on the first three-dimensional motion mechanism, the blood collection tube automatic barcode entry module is arranged on one side of the blood collection tube clamping module, the blood collection tube automatic barcode entry module sequentially scans and obtains the label barcodes of multiple blood collection tubes on the blood collection tube sample rack, the first three-dimensional motion mechanism is used to drive the blood collection tube clamping mechanism to perform three-dimensional movement on the blood collection tube, and the blood collection tube clamping module clamps the bottle cap of the blood collection tube; the blood collection tube clamping module is provided with a clamping claw and an empty clamping detector, the clamping claw clamps or releases the bottle cap of the blood collection tube by opening and closing, and the empty clamping detector can detect whether the clamping claw clamps the blood collection tube to avoid the situation where the blood collection tube is not clamped when it is rotated.

[0016] Furthermore, the liquid-adding robot arm includes a second three-dimensional motion mechanism and a pipetting module; the second three-dimensional motion mechanism drives the pipetting module to move, and the pipetting module is used to automatically remove the pipette tip, absorb the cell sample in the blood collection tube on the automatic labeling device, and transfer the cell sample to the cell culture tube containing the culture medium.

[0017] Furthermore, a pipette tip recovery box is also provided on the sample processing platform. The pipette tip recovery box is located on one side of the pipette tip holder and can receive the pipette tips removed by the liquid adding robot arm.

[0018] Furthermore, the automatic peripheral blood cell inoculator with automatic labeling also includes a waste gas adsorption treatment module; the waste gas adsorption treatment module is arranged on the top of the equipment cabin, and the waste gas adsorption treatment module serves as an absorption and transportation device for the gas in the equipment cabin; the waste gas adsorption treatment module includes a waste gas external exhaust fan, a waste gas adsorbent and a fan outer frame fixing frame; the waste gas external exhaust fan is installed on the top of the equipment cabin through the fan outer frame fixing frame; the waste gas adsorbent is arranged below the waste gas external exhaust fan.

[0019] Furthermore, the automatic peripheral blood cell inoculation instrument with automatic labeling also includes an ultraviolet disinfection module, which is composed of a multi-tube ultraviolet lamp and is used to disinfect the operating space area in the equipment cabin. The ultraviolet lamp is installed on the side wall or under the top of the equipment cabin, and the switch of the ultraviolet lamp is controlled by connecting to the control system signal.

[0020] The present application provides an automatic inoculator for peripheral blood cells with automatic labeling. By setting up an automatic labeling device, the cell culture tubes can be pressed and labeled. At the same time, each cell culture tube is clamped and transferred to the pressing unit by a liquid adding robot arm, and the labeled cell culture tube is transferred from the pressing unit to the culture tube holder. The clamping claw robot arm clamps the blood collection tube and places it on the pressing unit, rotates the blood collection tube to open the bottle cap, and the liquid adding robot arm inserts the pipette tip into the blood collection tube on the automatic labeling device and absorbs the cell sample, and then transfers the cell sample to the cell culture tube and mixes it with the culture medium, thereby realizing automatic labeling of the cell culture tube, comparing the barcode information of the blood collection tube with the cell culture tube, shortening the inoculation process, and facilitating automated inoculation and barcode management. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the overall structure of the automatic peripheral blood cell inoculator with automatic labeling of the utility model;

[0022] Figure 2 It is a front view of the automatic peripheral blood cell inoculation instrument with automatic labeling of the utility model;

[0023] Figure 3 It is a structural schematic diagram of the sample processing platform of the utility model;

[0024] Figure 4 This is a schematic diagram of the structure of the gripper mechanical arm of the utility model;

[0025] Figure 5 This is a schematic diagram of the structure of the liquid adding mechanical arm of the utility model;

[0026] Figure 6 This is a schematic diagram of the structure of the automatic labeling device of the utility model;

[0027] Figure 7 This is a schematic diagram of the structure of the automatic labeling device of the utility model;

[0028] Figure 8 This is a schematic diagram of the structure of the waste gas adsorption treatment module of the utility model;

[0029] Fig. 9 It is a structural schematic diagram of the ultraviolet disinfection module of the utility model.

[0030] The markings in the figure are as follows:

[0031] Sample processing platform 1, blood collection tube 10, cell culture tube 20, blood collection tube sample rack 11, automatic labeling device 12, label guide unit 121, support bottom plate 1211, paper roll fixing wheel 1212, paper feeding guide wheel 1213, label peeling mechanism 1214, paper collection guide wheel 1215, paper collection wheel 1216, pressing unit 122, mounting frame 1221, driving wheel 1222, driving motor 1223, pressing movable frame 1224, driven wheel 1225, pressing driving mechanism 1226, pipette tip bracket 13, culture tube bracket 14, pipette Gun tip recovery box 15, clamping claw robot arm 2, blood collection tube automatic barcode entry module 21, blood collection tube clamping module 22, first three-dimensional motion mechanism 23, liquid adding robot arm 3, second three-dimensional motion mechanism 31, pipetting module 32, equipment cabin 4, supporting mechanism 5, waste gas adsorption treatment module 6, waste gas external exhaust fan 61, waste gas adsorbent 62, fan outer frame fixing frame 63, ultraviolet disinfection module 7, ultraviolet lamp 71, bottom plate groove 81, top plate 82, shaft hole 821, sliding hole 822, driving wheel fixing frame 83, slide plate 91, horizontal push motor 92, slider 93. DETAILED DESCRIPTION

[0032] The utility model is further described below in conjunction with the accompanying drawings.

[0033] Example 1.

[0034] In this embodiment, see Figure 1 , Figure 2 , a peripheral blood cell automatic inoculator with automatic labeling, comprising an equipment cabin 4, a processing flow control device, a sample processing platform 1, a supporting mechanism 5, a clamping robot arm 2 and a liquid adding robot arm 3; the sample processing platform 1 is arranged at the bottom of the inner cavity of the equipment cabin 4, the two ends of the supporting mechanism 5 are connected to the equipment cabin 4 and are located above the sample processing platform 1, the clamping robot arm 2 and the liquid adding robot arm 3 are installed on the supporting mechanism 5, and the processing flow control device is arranged outside the equipment cabin 4.

[0035] The equipment cabin 4 is a closed structure, which can avoid contamination by impurities in the air. The equipment cabin 4 can fix the support mechanism 5, thereby fixing the gripper robot arm 2 and the liquid adding robot arm 3.

[0036] The processing flow control device includes a program controller and a human-machine interface; the program controller is used for signal control and monitoring of the entire machine; the human-machine interface is composed of a touch control screen, a computer or other human-machine dialogue device and a barcode entry device; the human-machine interface is used to input and output instrument operation parameters, record the instrument operation status and detailed process records of sample processing; the human-machine interface has a module with a network connection function, which monitors the instrument operation status in real time through the network connection, and sends the instrument operation status information and sample processing information to the information management system for recording and analysis; the human-machine interface has a barcode entry function graphic area, which is used to enter the barcode information of the processed sample and the input area for related information such as the reagent batch number used during the operation.

[0037] See also Figure 1 , Figure 2 , Figure 3 The sample processing platform 1 is provided with a blood collection tube sample rack 11, an automatic labeling device 12, a pipette tip holder 13 and a culture tube holder 14; the blood collection tube sample rack 11 is provided with a holder on which a plurality of blood collection tubes 10 are arranged; a plurality of pipette tips are arranged on the pipette tip holder 13; a plurality of cell culture tubes 20 are arranged on the culture tube holder 14; the processing flow control device is signal-connected with the gripper robot arm 2, the liquid adding robot arm 3 and the automatic labeling device 12.

[0038] See also Figure 6 The automatic labeling device 12 includes a label guiding unit 121 and a pressing unit 122. The label guiding unit 121 guides the release paper and separates the label on the release paper. The pressing unit 122 rolls and clamps the cell culture tube 20 and presses and attaches the separated label to the cell culture tube 20.

[0039] The gripper robot 2 can move between the blood collection tube sample rack 11, the automatic labeling device 12 and the culture tube support 14. The gripper robot 2 first scans and obtains the label barcodes of multiple blood collection tubes 10 on the blood collection tube sample rack 11 in sequence; the gripper robot 2 clamps and transfers each cell culture tube 20 to the pressing unit 122 for labeling, and transfers the labeled cell culture tube 20 from the pressing unit 122 to the original position on the culture tube support 14. The original label barcode on the blood collection tube 10 corresponds to the new label of the cell culture tube 20 one by one to achieve position matching; the gripper robot 2 clamps and transfers each blood collection tube 10 on the blood collection tube sample rack 11 to the pressing unit 122, the gripper robot 2 clamps the bottle cap of the blood collection tube 10 and rotates the blood collection tube 10 through the pressing unit 122 to open the bottle cap.

[0040] The liquid adding robot arm 3 can move between the automatic labeling device 12, the pipette tip holder 13 and the culture tube holder 14. The liquid adding robot arm 3 absorbs a pipette tip and inserts the pipette tip into the blood collection tube 10 on the automatic labeling device 12 and absorbs the cell sample, and then transfers the cell sample to the cell culture tube 20 to mix with the culture medium.

[0041] The automatic labeling device is provided to realize automatic labeling of the cell culture tube 20, and compare the barcode information of the blood collection tube with the cell culture tube, thereby achieving matching association, shortening the inoculation process, and facilitating automated inoculation and barcode management.

[0042] Example 2.

[0043] This embodiment is basically the same as the above embodiment, with the following features:

[0044] See also Figure 6 , Figure 7 The label guide unit 121 includes a supporting base plate 1211, a paper roll fixing wheel 1212, a paper feeding guide wheel 1213, a label peeling mechanism 1214, a paper receiving guide wheel 1215 and a paper receiving wheel 1216; the paper roll fixing wheel 1212, the paper feeding guide wheel 1213, the label peeling mechanism 1214, the paper receiving guide wheel 1215 and the paper receiving wheel 1216 are vertically fixed on the upper surface of the supporting base plate 1211, the label peeling mechanism 1214 is arranged adjacent to the laminating unit 122, the paper roll fixing wheel 1212 fixes the release paper, the paper feeding guide wheel 1213 guides the release paper from the paper roll fixing wheel 1212 to the label peeling mechanism 1214, the label peeling mechanism 1214 separates the label on the release paper, and the paper receiving guide wheel 1215 guides the release paper from the label peeling mechanism 1214 to the paper receiving wheel 1216 for recycling.

[0045] See also Figure 6 , Figure 7The pressing unit 122 includes a mounting frame 1221, a driving wheel 1222, a driving motor 1223, a clamping movable frame 1224, a driven wheel 1225 and a clamping driving mechanism 1226; the driving motor 1223 is mounted on the mounting frame 1221, the driving wheel 1222 is connected to the driving motor 1223 and is rotatably mounted on the mounting frame 1221, the clamping driving mechanism 1226 is mounted on the mounting frame 1221, the driven wheel 1225 is rotatably mounted on the clamping movable frame 1224, the driven wheel 1225 is arranged parallel to the driving wheel 1222 to form a space for clamping the blood collection tube 10, the clamping movable frame 1224 is mounted on the clamping driving mechanism 1226, and the clamping driving mechanism 1226 drives the driven wheel 1225 of the clamping movable frame 1224 to approach or move away from the driving wheel 1222 to clamp or release the blood collection tube 10.

[0046] See also Figure 7 The mounting frame 1221 includes a bottom plate groove 81, a top plate 82 and a driving wheel fixing frame 83. The top plate 82 is mounted on the bottom plate groove 81. The driving wheel fixing frame 83 and the label guide unit 121 are mounted on the top plate 82. The driving motor 1223 and the pressing driving mechanism 1226 are fixed in the bottom plate groove 81. The top plate 82 is provided with a rotating shaft hole 821 and a sliding hole corresponding to the driving motor 1223 and the pressing driving mechanism 1226. 822, the shaft of the driving motor 1223 passes through the shaft hole 821 and is connected to the bottom end of the driving wheel 1222, and the driving wheel fixing frame 83 is rotatably connected to the top end of the driving wheel 1222; the clamping driving mechanism 1226 passes through the sliding hole 822, the bottom end of the clamping driving mechanism 1226 is connected to the clamping driving mechanism 1226, and at least two driven wheels 1225 are arranged at the top end of the clamping driving mechanism 1226 corresponding to the driving wheel 1222.

[0047] See also Figure 7 The clamping drive mechanism 1226 includes a slide plate 91, a horizontal push motor 92 and a slider 93. The slide plate 91 is fixed in the bottom plate groove 81. The slider 93 can slide to the slide groove set on the slide plate 91. The horizontal push motor 92 drives the slider 93 to slide in the slide groove of the slide plate 91. The bottom end of the clamping movable frame 1224 passes through the sliding hole 822 and is connected to the slider 93. The top of the clamping movable frame 1224 is provided with a U-shaped portion, and the U-shaped portion is provided with at least two driven wheels 1225. The blood collection tube 10 is clamped between the driven wheel 1225 and the driving wheel 1222. The blood collection tube 10 rotates with the driving wheel 1222 to press and attach the separated label to the blood collection tube 10.

[0048] Preferably, two driven wheels 1225 are arranged on both sides of the U-shaped portion. When the blood collection tube 10 is placed between the driven wheel 1225 and the driving wheel 1222, the driven wheel 1225 of the clamping movable frame 1224 is driven by the clamping driving mechanism 1226 to approach the driving wheel 1222 to clamp the blood collection tube 10. The driving motor 1223 drives the driving wheel 1222 to rotate and drives the blood collection tube 10 to rotate, so that the blood collection tube 10 rotates with the driving wheel 1222 to press and attach the separated label to the blood collection tube 10. After the label is attached, the driven wheel 1225 of the clamping movable frame 1224 is driven by the clamping driving mechanism 1226 to move away from the driving wheel 1222 to loosen the blood collection tube 10 and move away the blood collection tube 10 with the attached label. Then, after scanning and acquiring the label barcodes of multiple blood collection tubes 10 on the blood collection tube sample rack 11 in sequence, the labeled blood collection tube 10 is placed between the driven wheel 1225 and the driving wheel 1222, and the driven wheel 1225 of the clamping movable frame 1224 is driven by the clamping drive mechanism 1226 to approach the driving wheel 1222 to clamp the blood collection tube 10. The blood collection tube clamping module 22 clamps and rotates the bottle cap of each blood collection tube 10 to open the bottle cap of the blood collection tube 10 fixed on the automatic labeling device 12.

[0049] Example 3.

[0050] This embodiment is basically the same as the above embodiment, with the following features:

[0051] See also Figure 4 The gripper robot 2 includes a first three-dimensional motion mechanism 23, a blood collection tube automatic barcode entry module 21 and a blood collection tube clamping module 22. The first three-dimensional motion mechanism 23 is used to drive the blood collection tube 10 clamping mechanism to perform three-dimensional motion on the blood collection tube 10. The gripper robot 2 can move between the culture tube support 14, the blood collection tube sample rack 11 and the automatic labeling device 12. The gripper robot 2 first scans and obtains the label barcodes of multiple blood collection tubes 10 on the blood collection tube sample rack 11 in sequence; the gripper robot 2 places each cell culture tube 10 on the culture tube support 14. The tube 20 is clamped and transferred to the pressing unit 122 for attaching a label, and the labeled cell culture tube 20 is transferred from the pressing unit 122 to the original position on the culture tube holder 14, and the original label barcode on the blood collection tube 10 corresponds to the new label of the cell culture tube 20 one by one to achieve position matching; the gripper robot 2 clamps each blood collection tube 10 on the blood collection tube sample rack 11 and transfers it to the pressing unit 122, and the gripper robot 2 clamps the bottle cap of the blood collection tube 10 and rotates the blood collection tube 10 through the pressing unit 122 to open the bottle cap.

[0052] The blood collection tube automatic barcode entry module 21 is a one-dimensional barcode module, which is used to automatically enter the barcode of the sample in the blood collection tube 10; preferably, the blood collection tube automatic barcode entry module 21 can be rotated to align with the barcode of the blood collection tube 10 on the blood collection tube sample rack 11 to realize the automation of sample barcode entry.

[0053] The first three-dimensional motion mechanism 23 is an XYZ three-dimensional motion mechanism. The blood collection tube clamping module 22 can grab the bottle cap of the blood collection tube 10 to transfer the blood collection tube 10 to the automatic labeling device 12. The automatic labeling device 12 clamps the blood collection tube 10, and the blood collection tube clamping module 22 can grab the bottle cap of the blood collection tube 10 for transfer.

[0054] When in use, a plurality of blood collection tubes 10 are first placed on the blood collection tube sample rack 11, and then the gripper robot arm 2 is started, and the blood collection tube clamping module 22 is used to sequentially grab the blood collection tubes 10, and the blood collection tube clamping module 22 places the grabbed blood collection tubes 10 to the automatic labeling device 12 for automatic pressing and clamping, and the blood collection tube 10 is rotated by the pressing unit 122 to open the bottle cap. The automatic labeling device 12 has the functions of clamping and rotating the blood collection tube 10 to open the cap and clamping the cell culture tube 20 to attach a new label, which reduces the number of components and reduces the volume of components.

[0055] Preferably, the blood collection tube clamping module 22 is provided with a clamping claw and a clamping empty detector. The clamping claw clamps or releases the bottle cap of the blood collection tube 10 by opening and closing, and the clamping empty detector can detect whether the clamping claw clamps the blood collection tube 10 to avoid the situation where the blood collection tube 10 is not clamped. The clamping empty detector can report an error when the clamping claw does not clamp the bottle cap of the blood collection tube 10 or set that the corresponding position on the blood collection tube sample rack 11 is not set with a blood collection tube 10.

[0056] Example 4.

[0057] This embodiment is basically the same as the above embodiment, with the following features:

[0058] See also Figure 5 The liquid adding robot arm 3 includes a second three-dimensional motion mechanism 31 and a pipetting module 32; the pipetting module 32 is installed on the second three-dimensional motion mechanism 31, and the second three-dimensional motion mechanism 31 drives the pipetting module 32 to move. The pipetting module 32 is used to automatically remove the pipette tip, absorb the cell sample in the blood collection tube 10 on the automatic labeling device 12, and transfer the cell sample to the cell culture tube 20 containing the culture medium.

[0059] The second three-dimensional motion mechanism 31 is an XYZ three-dimensional motion mechanism, and the pipetting module 32 is composed of an electric sample pump and a sensor. The electric sample pump realizes liquid suction and discharge through forward and reverse motion. The sensor is composed of a pressure sensor and a capacitance sensor. The pressure sensor is used to detect the pressure change in the pipeline to detect the volume pressure of the sample sucked into the pipette tip, and the capacitance sensor is used to detect the liquid level in the sample tube.

[0060] The pressure sensor is installed in the pipeline of the electric sample pump to detect slight pressure changes in the pipeline. When the electric sample pump absorbs the coagulation sample, the coagulation tissue blocks the sample tube. The pressure sensor is used to detect abnormal pressure changes in the pipeline, thereby realizing the detection of the coagulation sample. The capacitance sensor is connected to the pipette head of the electric sample pump through a wire. During the sample absorption process, the pipette head contacts the liquid surface in the sample tube. The electric sample pump detects the liquid surface by detecting the change in the capacitance value in the circuit, ensuring the accuracy and stability of the pipetting. Before the electric sample pump absorbs the liquid, it absorbs the sample through multiple suction and discharge operations to ensure the uniformity of the sample and the quality of the sample.

[0061] Example 5.

[0062] This embodiment is basically the same as the above embodiment, with the following features:

[0063] See also Figure 1 , Figure 2 The sample processing platform 1 is also provided with a pipette tip recovery box 15 , which is located on one side of the pipette tip support 13 and can receive the pipette tips removed by the liquid adding robot arm 3 .

[0064] After the pipette tip absorbs the cell sample in the blood collection tube 10 on the automatic labeling device 12 and transfers the cell sample to the cell culture tube 20 containing the culture medium, the liquid adding robot arm 3 moves the pipette tip to the top of the pipette tip recovery box 15, removes the pipette tip, and drops it into the pipette tip recovery box 15.

[0065] Example 6.

[0066] This embodiment is basically the same as the above embodiment, with the following features:

[0067] See also Figure 1 , Figure 2 , Figure 8, including an exhaust gas adsorption treatment module 6; the exhaust gas adsorption treatment module 6 is arranged on the top of the equipment cabin 4, and the exhaust gas adsorption treatment module 6 serves as an absorption and transportation device for the gas in the equipment cabin 4; the exhaust gas adsorption treatment module 6 includes an exhaust gas external exhaust fan 61, an exhaust gas adsorbent 62 and a fan outer frame fixing frame 63; the exhaust gas external exhaust fan 61 is installed on the top of the equipment cabin 4 through the fan outer frame fixing frame 63; the exhaust gas adsorbent 62 is arranged below the exhaust gas external exhaust fan 61.

[0068] This embodiment adopts the exhaust gas adsorption treatment module 6, which adds an external exhaust device on the basis of the traditional exhaust gas adsorption, so as to effectively and completely remove the harmful exhaust gas generated in the sample processing process.

[0069] Example 7.

[0070] This embodiment is basically the same as the above embodiment, with the following features:

[0071] See also Figure 1 , Figure 2 , Fig. 9 , including an ultraviolet disinfection module 7, which is composed of a multi-tube ultraviolet lamp 71 and is used to disinfect the operating space area in the equipment cabin 4. The ultraviolet lamp 71 is installed on the side wall or under the top of the equipment cabin 4, and the switch of the ultraviolet lamp 71 is controlled by connecting to the control system signal.

[0072] This embodiment adopts a module design of ultraviolet disinfection, which effectively protects the health of operators and the biosafety of the environment.

[0073] The embodiments of the utility model are described above in conjunction with the accompanying drawings, but the utility model is not limited to the above embodiments, and various changes can be made according to the purpose of the invention of the utility model. Any changes, modifications, substitutions, combinations or simplifications made according to the spirit and principle of the technical solution of the utility model should be equivalent replacement methods. As long as they meet the purpose of the invention of the utility model and do not deviate from the technical principles and inventive concepts of the utility model, they belong to the protection scope of the utility model.

Claims

1. An automatic peripheral blood cell inoculator with automatic labeling, characterized in that: It comprises an equipment cabin, a processing flow control device, a sample processing platform, a supporting mechanism, a gripper mechanical arm and a liquid adding mechanical arm; the sample processing platform is arranged at the bottom of the inner cavity of the equipment cabin, the two ends of the supporting mechanism are connected to the equipment cabin and are located above the sample processing platform, the gripper mechanical arm and the liquid adding mechanical arm are installed on the supporting mechanism, and the processing flow control device is arranged outside the equipment cabin; The sample processing platform is provided with a blood collection tube sample rack, an automatic labeling device, a pipette tip holder and a culture tube holder; a plurality of blood collection tubes are provided on the blood collection tube sample rack; a plurality of pipette tips are provided on the pipette tip holder; a plurality of cell culture tubes are provided on the culture tube holder; the processing flow control device is signal-connected with the gripper mechanical arm, the liquid adding mechanical arm and the automatic labeling device; The automatic labeling device comprises a label guiding unit and a pressing unit, wherein the label guiding unit guides the release paper and separates the label on the release paper, and the pressing unit rolls and clamps the cell culture tube and presses and attaches the separated label to the cell culture tube; The gripper robot arm is capable of moving between the blood collection tube sample rack, the automatic labeling device and the culture tube support, and the gripper robot arm sequentially scans and obtains the label bar codes of multiple blood collection tubes on the blood collection tube sample rack; the gripper robot arm clamps and transfers each cell culture tube to the pressing unit for labeling, and transfers the labeled cell culture tube from the pressing unit to the culture tube support; the gripper robot arm clamps and transfers each blood collection tube on the blood collection tube sample rack to the pressing unit, and the gripper robot arm clamps the bottle cap of the blood collection tube and rotates the blood collection tube through the pressing unit to open the bottle cap; The liquid adding robot arm can move between the automatic labeling device, the pipette tip holder and the culture tube holder. The liquid adding robot arm absorbs a pipette tip and inserts the pipette tip into the blood collection tube on the automatic labeling device and absorbs the cell sample, and then transfers the cell sample to the cell culture tube and mixes it with the culture medium.

2. The automatic peripheral blood cell inoculator with automatic labeling according to claim 1, characterized in that: The label guide unit includes a supporting base plate, a paper roll fixing wheel, a paper feeding guide wheel, a label peeling mechanism, a paper receiving guide wheel and a paper receiving wheel; the paper roll fixing wheel, the paper feeding guide wheel, the label peeling mechanism, the paper receiving guide wheel and the paper receiving wheel are vertically fixed to the upper surface of the supporting base plate, the label peeling mechanism is arranged adjacent to the lamination unit, the paper roll fixing wheel fixes the release paper, the paper feeding guide wheel guides the release paper from the paper roll fixing wheel to the label peeling mechanism, the label peeling mechanism separates the label on the release paper, and the paper receiving guide wheel guides the release paper from the label peeling mechanism to the paper receiving wheel for recycling.

3. The automatic peripheral blood cell inoculator with automatic labeling according to claim 1, characterized in that: The pressing unit includes a mounting frame, a driving wheel, a driving motor, a clamping movable frame, a driven wheel and a clamping driving mechanism; the driving motor is mounted on the mounting frame, the driving wheel is connected to the driving motor and is rotatably mounted on the mounting frame, the clamping driving mechanism is mounted on the mounting frame, the driven wheel is rotatably mounted on the clamping movable frame, the driven wheel is arranged parallel to the driving wheel to form a space for clamping the blood collection tube, the clamping movable frame is mounted on the clamping driving mechanism, and the clamping driving mechanism drives the driven wheel of the clamping movable frame to approach or move away from the driving wheel to clamp or loosen the blood collection tube.

4. The automatic peripheral blood cell inoculator with automatic labeling according to claim 3, characterized in that: The mounting frame includes a bottom plate groove, a top plate and a driving wheel fixing frame, the top plate is installed on the bottom plate groove, the driving wheel fixing frame and the label guide unit are installed on the top plate, the driving motor and the clamping driving mechanism are fixed in the bottom plate groove, the top plate is respectively provided with a shaft hole and a sliding hole corresponding to the driving motor and the clamping driving mechanism, the shaft of the driving motor passes through the shaft hole and is connected to the bottom end of the driving wheel, the driving wheel fixing frame is rotatably connected to the top end of the driving wheel; the clamping driving mechanism passes through the sliding hole, the bottom end of the clamping driving mechanism is connected to the clamping driving mechanism, and at least two driven wheels are arranged at the top end of the clamping driving mechanism corresponding to the driving wheel.

5. The automatic peripheral blood cell inoculator with automatic labeling according to claim 4, characterized in that: The clamping drive mechanism includes a slide plate, a horizontal push motor and a slider, the slide plate is fixed in the bottom plate groove, the slider can slide to the slide groove set on the slide plate, the horizontal push motor drives the slider to slide in the slide groove of the slide plate, the bottom end of the clamping movable frame is connected to the slider through the sliding hole, the top of the clamping movable frame is provided with a U-shaped part, the U-shaped part is provided with at least two driven wheels, the blood collection tube is clamped between the two driven wheels and the driving wheel, and the blood collection tube rotates with the driving wheel to press and attach the separated label to the blood collection tube.

6. The automatic peripheral blood cell inoculator with automatic labeling according to claim 1, characterized in that: The clamping robot arm includes a first three-dimensional motion mechanism, a blood collection tube automatic barcode entry module and a blood collection tube clamping module, the blood collection tube clamping module is installed on the first three-dimensional motion mechanism, the blood collection tube automatic barcode entry module is arranged on one side of the blood collection tube clamping module, the blood collection tube automatic barcode entry module sequentially scans and obtains the label barcodes of multiple blood collection tubes on the blood collection tube sample rack, the first three-dimensional motion mechanism is used to drive the blood collection tube clamping mechanism to perform three-dimensional motion on the blood collection tube, the blood collection tube clamping module clamps the bottle cap of the blood collection tube; the blood collection tube clamping module is provided with a clamping claw and a clamping empty detector, the clamping claw clamps or releases the bottle cap of the blood collection tube by opening and closing, and the clamping empty detector can detect whether the clamping claw clamps the blood collection tube.

7. The automatic peripheral blood cell inoculator with automatic labeling according to claim 1, characterized in that: The liquid-adding robot arm includes a second three-dimensional motion mechanism and a pipetting module; the pipetting module is installed on the second three-dimensional motion mechanism, and the second three-dimensional motion mechanism drives the pipetting module to move. The pipetting module is used to automatically remove the pipette tip, absorb the cell sample in the blood collection tube on the automatic labeling device, and transfer the cell sample to the cell culture tube containing the culture medium.

8. The automatic peripheral blood cell inoculation instrument with automatic labeling according to claim 1, characterized in that: The sample processing platform is also provided with a pipette tip recovery box, which is located on one side of the pipette tip support and can receive the pipette tips removed by the liquid adding robot arm.

9. The automatic peripheral blood cell inoculator with automatic labeling according to claim 1, characterized in that: The automatic peripheral blood cell inoculator with automatic labeling also includes a waste gas adsorption treatment module; the waste gas adsorption treatment module is arranged on the top of the equipment cabin, and the waste gas adsorption treatment module serves as an absorption and transportation device for the gas in the equipment cabin; the waste gas adsorption treatment module includes a waste gas external exhaust fan, a waste gas adsorbent and a fan outer frame fixing frame; the waste gas external exhaust fan is installed on the top of the equipment cabin through the fan outer frame fixing frame; the waste gas adsorbent is arranged below the waste gas external exhaust fan.

10. The automatic peripheral blood cell inoculation instrument with automatic labeling according to claim 1, characterized in that: The peripheral blood cell automatic inoculator with automatic labeling also includes an ultraviolet disinfection module, which is composed of a multi-tube ultraviolet lamp and is used to disinfect the operating space area in the equipment cabin. The ultraviolet lamp is installed on the side wall or under the top of the equipment cabin, and the switch of the ultraviolet lamp is controlled by connecting to the control system signal.

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