Plasma sample preservation device
By adopting articulated structure and mechanical sealing technology in the plasma sample storage device, the problems of temperature fluctuations and cold air loss in the existing devices are solved, and the stable low-temperature storage of plasma samples is achieved, and the portability of the device is improved.
Patent Information
- Application Number
- CN202420863481.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-24
- Publication Date
- 2024-12-27
- Estimated Expiration
- 2034-04-24
AI Technical Summary
The existing plasma sample storage device cannot effectively reduce temperature fluctuations and air loss, resulting in unstable storage of plasma samples under 4°C environment, and the device is large inconvenient for transportation.
A plasma sample storage device is designed, using a hinged box and box cover, with matrix-distributed openings and storage components, including storage tubes, sealing caps, connecting rods and sealing caps, and mechanical structures of springs and connecting rods. The sealed cover is automatically lifted and lowered, and the semiconductor refrigeration sheet and temperature sensor are used to maintain a stable temperature of 4°C.
It effectively reduces the loss of air conditioning during test tube placement or removal, ensures the stability of plasma samples stored at low temperatures, and makes the device easier to transport through a compact design.
Smart Images
Figure CN222248319U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of blood samples, in particular to a plasma sample storage device. Background Art
[0002] Plasma renin activity measurement refers to the measurement of plasma renin activity. The renin-angiotensin system mainly includes: renin, angiotensinogen, angiotensin, and aldosterone. Renin is mainly produced, stored, and secreted by renal juxtaglomerular cells. Angiotensinogen mainly originates from the liver. Angiotensinogen in the circulation generates angiotensin I under the action of renin, and angiotensin I generates angiotensin II (Ang II) through the action of angiotensin converting enzyme in the pulmonary circulation. Angiotensin II has a strong vasoconstrictive effect. It also acts on the zona glomerulosa of the adrenal cortex to stimulate the synthesis of aldosterone. Angiotensin II generates angiotensin III through the action of aminopeptidase. The detection of renin content in human plasma is expressed in the form of renin activity. The rate at which endogenous renin in plasma catalyzes angiotensinogen to produce angiotensin I is called plasma renin activity. The content of angiotensin II in plasma can be directly measured by radioimmunoassay. Both standing and exercising can stimulate the renal sympathetic nervous system, increasing the secretion of renin, angiotensin II, and aldosterone; sodium-excreting diuretics reduce blood volume and can also promote the secretion of renin, Ang II, and aldosterone.
[0003] Renin determination: (1) Determination of peripheral circulating renin activity. The pressor effect of the renin-angiotensin system has been recognized, but the level and activity of renin in the body are not simply parallel to the height of blood pressure. This non-parallel phenomenon is mainly related to the body's regulatory function of renin secretion. Because there are large "false positive" and "false negative" rates in peripheral circulating renin activity, it makes diagnosis difficult. It is believed that if the peripheral circulating renin value is <5nGAI / (ml·hr), renal vascular hypertension can be basically excluded; if it is greater than this value, it indicates the possibility of renal vascular hypertension and further test of lateral renal vein renin activity or angiotensin blocker test should be performed.
[0004] ⑵ Determination of renal vein renin on both sides: Determine the ratio of renin activity in both renal veins (ipsilateral renin / contralateral renin RVRR) and the level of peripheral circulating renin or the ratio of contralateral renal vein renin to peripheral blood renin. It is generally believed that when the peripheral blood renin activity is high and the difference in renin activity between the two renal veins is greater than 2 times, the surgical effect is good. Kaufman reported an effective rate of 93%; when the peripheral blood renin activity is normal or the ratio of contralateral renal vein to peripheral blood renin is lower than 1.3 and the difference in renin activity between the two renal veins is greater than 1.4 times, the blood pressure after surgery usually returns to normal or decreases significantly; if the ratio of renin activity on both sides is less than 1.4, the surgical effect is poor and the false positive rate is about 7%.
[0005] Vaughan (1985) also believed that when the renal vein-renin ratio was 1.5:1, 90% of renal vascular hypertension could achieve good surgical results, but a negative ratio could not rule out a satisfactory response after surgery, and its false negative rate was about 15% (62 / 412). On the other hand, a positive RVRR could not rule out bilateral lesions. Correction of unilateral lesions could not completely correct the basic pathological changes, so hypertension could not be effectively controlled. For this reason, Vaughan pointed out that the indicators for diagnosing renal vascular hypertension should meet the following points: ① Use the renin sodium index, that is, use captopril stimulation to show high secretion of renin; ② Confirm that there is no renin secretion on the opposite side, V2-A2=0 (representing the renin values of the renal vein and renal artery, respectively); ③ In unilateral high-renin renal vascular hypertension, V-IVCV / IVC≥0.5 (IVC refers to the renin value of the inferior vena cava), while primary hypertension is different, regardless of whether the peripheral renin is normal or elevated, V-IVC / IVC on both sides is equal to 0.25.
[0006] The conditions for measuring plasma renin activity are relatively harsh and need to be kept in an environment of 4°C, otherwise the composition will change, making the test results of no reference value; some devices currently used cannot accurately maintain the temperature near 4 degrees Celsius, and are large in size and inconvenient to transport, so a convenient and compact device that can stably control the temperature is needed.
[0007] The existing Chinese patent with the announcement number CN215362860U discloses a sample storage box dedicated to the determination of plasma renin activity, including an outer box, a cold storage room and an electric control compartment, characterized in that: the electric control compartment is located at the lower section inside the outer box, and the cold storage room is located at the middle and upper sections inside the outer box; the inner wall of the outer box opening is provided with a sliding track, and two compartment doors can be slidably installed in the sliding track; a semiconductor refrigeration plate is fixedly installed between the electric control compartment and the cold storage room. The utility model uses heat-insulating materials for the compartment door and the inner wall of the cold storage room, which can reduce the heat transfer between the cold storage room and the outside, and a semiconductor refrigeration plate is installed at the bottom of the cold storage room, which can reduce the temperature inside the cold storage room; a temperature sensor is installed on the inner wall of the cold storage room to detect the temperature and stabilize the temperature within a certain range; an indicator light, a switch and a charging port are provided on the outer box; the two compartment doors can slide along the slide rail to reduce the heat transfer when the door is opened; a test tube rack is provided in the cold storage room to place sample test tubes.
[0008] In view of the above-mentioned and existing related technologies, the inventors believe that the following defects often exist: the device can slide along the slide rail through two doors to reduce heat transfer when the door is opened, but when placing or removing the test tube, half of the outer box opening is in an open state, so that the cold air will still be lost to a certain extent, and the door is slidably installed, and it is easy to slide under the influence of external force, causing the outer box to open, affecting the preservation effect, and needs to be improved; therefore, a plasma sample preservation device is proposed to address the above problems. Utility Model Content
[0009] In order to make up for the deficiencies of the prior art and solve the above-mentioned technical problems, the utility model provides a plasma sample storage device.
[0010] The technical solution adopted by the utility model to solve its technical problems is: a plasma sample storage device described in the utility model comprises a box body and a hinged box cover, the box cover is equipped with a handle, the upper and lower parts of the box body are respectively fixedly connected with a placing table and a partition, the surface of the placing table is provided with openings distributed in a matrix, and the upper and lower parts of the openings are installed with a storage component, the storage component comprises a storage tube and a threaded ring, the storage tube is fixedly installed at the corresponding opening at the bottom of the placing table, the bottom end of the storage tube is plugged with a sealing cover, the bottom of the sealing cover is fixedly connected with a spring 1, and the bottom end of the spring 1 is fixedly connected to the partition, the surface of the sealing cover is symmetrically fixedly connected with a connecting rod, the connecting rod passes through the placing table and is fixedly connected with an upper ring body, the threaded ring The ring is fixedly installed on the top of the placement table, and the threaded ring is coaxially arranged with the opening, the external thread of the threaded ring is connected with a sealing cap, and the inside of the sealing cap is fixedly connected with an annular raised layer. When placing or taking out the test tube, the sealing cap is opened, and the sealing cover rises through the elastic force of spring 1 to press against the bottom end of the storage tube to seal and reduce heat transfer. After the test tube is placed or taken out, the sealing cap is connected to the threaded ring to seal the top of the storage tube. At this time, the raised layer presses down on the upper ring body, and the sealing cap is pushed downward by the connecting rod, thereby opening the bottom end of the storage tube, allowing cold air to enter the interior of the storage tube to cool the test tube, thereby realizing low-temperature storage of the plasma sample test tube. Compared with the prior art, when placing or taking out the test tube, the loss of cold air is reduced, which can greatly reduce heat transfer.
[0011] Preferably, a semiconductor refrigeration chip, a temperature sensor, a battery module and a controller are fixedly connected to the bottom of the box, and a display control module and a charging interface are installed on the outside of the box. The controller is electrically connected to the semiconductor refrigeration chip, the temperature sensor, the battery module, the display control module and the charging interface. When in use, the display control module controls the operation of the semiconductor refrigeration chip to cool the inside of the box until it reaches 4 degrees Celsius. The temperature is detected by the temperature sensor and displayed in real time on the display control module, thereby controlling the operation of the semiconductor refrigeration chip to stabilize the temperature at around 4 degrees Celsius.
[0012] Preferably, the box body, the placement table, the storage tube, the sealing cover and the sealing cap are made of heat-insulating materials.
[0013] Preferably, a sealing gasket is fixedly connected to the surface of the sealing cover, and the sealing gasket improves the sealing effect between the sealing cover and the storage tube.
[0014] Preferably, a sealing ring is installed at the intersection of the placement platform and the connecting rod, so as to improve the sealing effect of the intersection of the placement platform and the connecting rod.
[0015] Preferably, the inner diameter of the storage tube is the same as the outer diameter of the test tube, and the length of the storage tube is longer than the length of the test tube.
[0016] Preferably, a test tube retrieval assembly is installed at the bottom of the storage tube, and the test tube retrieval assembly includes an annular bracket and an annular base arranged from top to bottom, the annular bracket and the annular base are installed inside the storage tube, and the annular base is fixedly installed at the bottom of the storage tube. When placing the test tube, the test tube is inserted into the interior of the storage tube, and the annular bracket is pushed downward to make the test tube enter the interior of the storage tube. When the test tube needs to be taken out, the sealing cap is opened, and the test tube rises upward by the elastic force of spring 2, which is convenient for taking the test tube.
[0017] Preferably, a second spring is fixedly connected to the opposite end of the annular bracket and the annular base.
[0018] Preferably, a rubber ring is fixedly connected to the top of the annular bracket, and a rubber pad is fixedly connected to the inside of the sealing cover, and the sealing ring and the sealing pad respectively support the two ends of the test tube for buffering, thereby improving the protective effect.
[0019] The utility model is beneficial in that:
[0020] 1. When placing or taking out a test tube, the utility model opens the sealing cap, and then the sealing cover is pressed against the bottom end of the storage tube to seal and reduce heat transfer. After the test tube is placed or taken out, the sealing cap is connected to the threaded ring to seal the top end of the storage tube and the bottom end of the storage tube is opened, so that cold air enters the interior of the storage tube to cool the test tube, thereby realizing low-temperature storage of the plasma sample test tube. When the threaded cap is opened, the internal space of the box is automatically and quickly closed, effectively reducing the loss of heat. Compared with the prior art, when placing or taking out the test tube, the loss of cold air is reduced, which can greatly reduce heat transfer.
[0021] 2. When placing a test tube, the utility model inserts the test tube into the interior of the storage tube, and pushes the annular bracket downward to allow the test tube to enter the interior of the storage tube. When the test tube needs to be taken out, the sealing cap is opened, and the test tube rises upward by the elastic force of the second spring, making it easy to take the test tube. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.
[0023] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0024] Figure 2 This is a schematic diagram of the internal structure of the box of the utility model;
[0025] Figure 3 This is a schematic diagram of the expanded structure of the holding component of the utility model;
[0026] Figure 4 This is a schematic diagram of the internal structure of the storage tube of the utility model;
[0027] Figure 5 This is a schematic diagram of the structure of the test tube taking and placing component of the utility model.
[0028] In the figure: 1. box body; 2. display control module; 3. placement table; 4. opening; 5. storage component; 51. storage tube; 52. sealing cover; 53. spring one; 54. connecting rod; 55. upper ring body; 56. threaded ring; 57. sealing cap; 58. raised layer; 6. partition; 7. test tube taking and placing component; 71. ring bracket; 72. ring base; 73. spring two; 74. rubber ring; 8. box cover. DETAILED DESCRIPTION
[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0030] Embodiment 1
[0031] See also Figure 1-3As shown, a plasma sample storage device comprises a box body 1 and a hinged box cover 8, wherein a placing table 3 and a partition 6 are fixedly connected to the upper and lower parts of the box body 1 respectively, the surface of the placing table 3 is provided with openings 4 distributed in a matrix, and a storage component 5 is installed above and below the opening 4, and the storage component 5 comprises a storage tube 51 and a threaded ring 56, the storage tube 51 is fixedly installed at the bottom of the placing table 3 corresponding to the opening 4, a sealing cover 52 is inserted at the bottom of the storage tube 51, a spring 53 is fixedly connected to the bottom of the sealing cover 52, and the bottom end of the spring 53 is fixedly connected to the partition 6, a connecting rod 54 is symmetrically fixedly connected to the surface of the sealing cover 52, the connecting rod 54 passes through the placing table 3 and is fixedly connected to an upper ring body 55, and a threaded ring 56 is fixedly installed on the top of the placing table 3, and the threaded ring 56 is coaxial with the opening 4 The outer thread of the threaded ring 56 is connected with a sealing cap 57, and the inside of the sealing cap 57 is fixedly connected with an annular raised layer 58. When placing or taking out the test tube, the sealing cap 57 is opened, and the sealing cover 52 rises due to the elastic force of the spring 53 to press against the bottom end of the storage tube 51 to seal and reduce heat transfer. After the test tube is placed or taken out, the sealing cap 57 is connected to the threaded ring 56 to seal the top of the storage tube 51. At this time, the raised layer 58 presses down on the upper ring body 55, and the sealing cap 57 is pushed downward by the connecting rod 54, thereby opening the bottom end of the storage tube 51, so that cold air enters the interior of the storage tube 51 to cool the test tube, thereby realizing low-temperature storage of the plasma sample test tube. Compared with the prior art, when placing or taking out the test tube, the loss of cold air is reduced, which can greatly reduce heat transfer.
[0032] A semiconductor refrigeration chip, a temperature sensor, a battery module and a controller are fixedly connected to the bottom of the box 1. A display control module 2 and a charging interface are installed on the outside of the box 1. The controller is electrically connected to the semiconductor refrigeration chip, the temperature sensor, the battery module, the display control module 2 and the charging interface. When in use, the display control module 2 controls the operation of the semiconductor refrigeration chip to cool the inside of the box 1 until it reaches 4 degrees Celsius. The temperature is detected by the temperature sensor and displayed in real time on the display control module 2, thereby controlling the operation of the semiconductor refrigeration chip to stabilize the temperature at around 4 degrees Celsius.
[0033] The box body 1, the placement table 3, the storage tube 51, the sealing cover 52 and the sealing cap 57 are made of heat-insulating materials.
[0034] A sealing gasket is fixedly connected to the surface of the sealing cover 52 , and the sealing gasket improves the sealing effect between the sealing cover 52 and the storage tube 51 .
[0035] A sealing ring is installed at the intersection of the placement platform 3 and the connecting rod 54, and the sealing ring improves the sealing effect of the intersection of the placement platform 3 and the connecting rod 54.
[0036] Embodiment 2
[0037] For comparison with Example 1, please refer to Figure 3-5 As shown, the utility model provides another embodiment, the inner diameter of the storage tube 51 is the same as the outer diameter of the test tube, and the length of the storage tube 51 is longer than the length of the test tube.
[0038] A test tube placement assembly 7 is installed at the bottom of the storage tube 51. The test tube placement assembly 7 includes an annular bracket 71 and an annular base 72 arranged from top to bottom. The annular bracket 71 and the annular base 72 are installed inside the storage tube 51. The annular base 72 is fixedly installed at the bottom of the storage tube 51. When placing the test tube, the test tube is inserted into the storage tube 51, and the annular bracket 71 is pushed downward to make the test tube enter the storage tube 51. When the test tube needs to be taken out, the sealing cap 57 is opened, and the test tube rises upward due to the elastic force of the spring 2 73, which is convenient for taking the test tube.
[0039] A second spring 73 is fixedly connected to one opposite end of the annular bracket 71 and the annular base 72 .
[0040] A rubber ring 74 is fixedly connected to the top of the annular bracket 71, and a rubber pad is fixedly connected to the inside of the sealing cover 52. The sealing ring and the sealing pad respectively support the two ends of the test tube for buffering, thereby improving the protection effect.
[0041] The parts not involved in the device are the same as those in the prior art or can be implemented by using the prior art.
[0042] Working principle: When in use, the display control module 2 is used to control the operation of the semiconductor refrigeration chip to cool down the inside of the box 1 until it reaches 4 degrees Celsius. The temperature is detected by the temperature sensor and displayed in real time on the display control module 2, thereby controlling the operation of the semiconductor refrigeration chip to stabilize the temperature at around 4 degrees Celsius.
[0043] When placing or removing the test tube, the sealing cap 57 is opened, and the sealing cover 52 rises due to the elastic force of the spring 53 to press against the bottom end of the storage tube 51 to seal and reduce heat transfer. After the test tube is placed or removed, the sealing cap 57 is connected to the threaded ring 56 to seal the top of the storage tube 51. At this time, the raised layer 58 presses down on the upper ring body 55, and the sealing cap 57 is pushed downward by the connecting rod 54, thereby opening the bottom end of the storage tube 51, allowing cold air to enter the interior of the storage tube 51 to cool the test tube, thereby realizing low-temperature storage of the plasma sample test tube. Compared with the prior art, when placing or removing the test tube, the loss of cold air is reduced, which can greatly reduce heat transfer.
[0044] When placing a test tube, the test tube is inserted into the interior of the storage tube 51, and the annular bracket 71 is pushed downward to allow the test tube to enter the interior of the storage tube 51. When the test tube needs to be taken out, the sealing cap 57 is opened, and the test tube rises upward through the elastic force of the spring 2 73, making it easy to take out the test tube.
[0045] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.
[0046] The above shows and describes the basic principle, main features and advantages of the utility model. Those skilled in the art should understand that the utility model is not limited by the above embodiments, and the above embodiments and descriptions are only for explaining the principle of the utility model. Without departing from the spirit and scope of the utility model, the utility model may have various changes and improvements, and these changes and improvements fall within the scope of the utility model to be protected.
Claims
1. A plasma sample storage device, comprising a box body (1) and a hinged box cover (8), characterized in that: The upper and lower parts of the box body (1) are respectively fixedly connected with a placing table (3) and a partition (6); the surface of the placing table (3) is provided with openings (4) distributed in a matrix; the upper and lower parts of the openings (4) are provided with a storage assembly (5); the storage assembly (5) comprises a storage tube (51) and a threaded ring (56); the storage tube (51) is fixedly installed at the bottom of the placing table (3) corresponding to the opening (4); the bottom end of the storage tube (51) is plugged with a sealing cover (52); the bottom of the sealing cover (52) is fixedly connected with a spring Spring 1 (53), and the bottom end of spring 1 (53) is fixedly connected to the partition (6), the surface of the sealing cover (52) is symmetrically fixedly connected with a connecting rod (54), the connecting rod (54) passes through the placement table (3) and is fixedly connected with an upper ring body (55), the threaded ring (56) is fixedly installed on the top of the placement table (3), and the threaded ring (56) is coaxially arranged with the opening (4), the external thread of the threaded ring (56) is connected with a sealing cap (57), and the inside of the sealing cap (57) is fixedly connected with an annular raised layer (58).
2. The plasma sample storage device according to claim 1, characterized in that: The bottom of the box (1) is fixedly connected with a semiconductor cooling chip, a temperature sensor, a battery module and a controller, the outside of the box (1) is installed with a display control module (2) and a charging interface, and the controller is electrically connected with the semiconductor cooling chip, the temperature sensor, the battery module, the display control module (2) and the charging interface.
3. The plasma sample storage device according to claim 1, characterized in that: The box body (1), the placement table (3), the storage tube (51), the sealing cover (52) and the sealing cap (57) are made of heat-insulating materials.
4. The plasma sample storage device according to claim 1, characterized in that: A sealing gasket is fixedly connected to the surface of the sealing cover (52).
5. The plasma sample storage device according to claim 1, characterized in that: A sealing ring is installed at the intersection of the placement platform (3) and the connecting rod (54).
6. The plasma sample storage device according to claim 1, characterized in that: The inner diameter of the storage tube (51) is the same as the outer diameter of the test tube, and the length of the storage tube (51) is longer than the length of the test tube.
7. The plasma sample storage device according to claim 1, characterized in that: A test tube placement assembly (7) is installed at the bottom of the storage tube (51), and the test tube placement assembly (7) comprises an annular bracket (71) and an annular base (72) arranged from top to bottom, the annular bracket (71) and the annular base (72) are installed inside the storage tube (51), and the annular base (72) is fixedly installed at the bottom of the storage tube (51).
8. The plasma sample storage device according to claim 7, characterized in that: A second spring (73) is fixedly connected to the opposite end of the annular bracket (71) and the annular base (72).
9. The plasma sample storage device according to claim 7, characterized in that: A rubber ring (74) is fixedly connected to the top of the annular bracket (71).