Portable SPR (Surface Plasmon Resonance) biomolecule interaction analysis device
By designing the housing and shaking components in the bioanalyzer, the problem of poor carrying stability of the bioanalyzer is solved, and more stable carrying and more uniform sample processing is achieved, reducing detection errors.
Patent Information
- Application Number
- CN202420468884.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-12
- Publication Date
- 2024-12-27
- Estimated Expiration
- 2034-03-12
AI Technical Summary
Existing bioanalyzers have poor stability when carried and cannot be effectively fixed, resulting in the problem of debris scattering.
A portable SPR biomolecular interaction analysis device is designed, using shell, positioning block, threaded rod, rotary handle, fixing plate, sliding block and box door. By effectively fixing the bioanalyzer, the carrying stability is increased, and the Structures such as brackets, ear tables, convex plates, round rods and motors shake the test tubes to avoid solution stratification and improve sample uniformity.
It improves the carrying stability of the bioanalyzer, reduces the error of the detection data, and ensures sample uniformity and analysis accuracy.
Smart Images
Figure CN222250738U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of bioanalyzers, in particular to a portable SPR biomolecule interaction analysis device. Background Art
[0002] The bioanalyzer is based on virtual instrument control, real-time display of SPR curves and sensor diagrams, easy to operate, and convenient for users to observe and analyze. The Kretschmann structure is used to build a high-precision optical sensing system, with an 850nm LED as the incident light source. The sample is analyzed and measured by changing the angle of the incident light. The external pump is used for sampling operation. Customers can configure different models of peristaltic pumps or syringe pumps for sampling according to their needs. It is easy to operate and update.
[0003] However, the existing bioanalyzer housing has poor stability when the bioanalyzer is carried, is prone to shaking when carried, and cannot be effectively fixed, which has defects. Therefore, those skilled in the art provide a portable SPR biomolecular interaction analysis device to solve the problems raised in the above background technology. Utility Model Content
[0004] In order to make up for the above shortcomings, the utility model provides a portable SPR biomolecular interaction analysis device, which aims to improve the problem that the prior art cannot collect debris, resulting in the debris floating everywhere.
[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:
[0006] A portable SPR biomolecule interaction analysis device comprises a shell, an analyzer is arranged inside the shell, a positioning block is fixedly connected to the outside of the shell, a threaded rod is threadedly connected to the inside of the positioning block, a handle is fixedly connected to the lower part of the threaded rod, a fixed plate is arranged on the upper part of the threaded rod, a sliding block is fixedly connected to the threaded rod, a sliding rod is slidably connected to the outside of the sliding block, the sliding rod is arranged inside the fixed plate, sliding grooves are provided on both sides of the inside of the shell, a box door is hinged on the shell, a limiting block is fixedly connected to the upper right side of the box door, a fixed block is fixedly connected to the upper right side of the shell, a locking screw is threadedly connected to the internal part of the fixed block, and a shaking component is arranged inside the analyzer.
[0007] Furthermore, the shaking assembly includes a bracket, which is fixedly connected to the left side of the inside of the analyzer, an ear platform is provided on the upper part of the bracket, the bottom of the ear platform is rotatably connected to a round rod through a bearing, the bottom of the round rod passes through the bottom of the bracket and is fixed with a convex plate, a motor is fixed to the bottom of the bracket, the output shaft of the motor is fixedly connected to the bottom of the convex plate, the front and rear sides of the ear platform are fixedly connected with a round plate, the front and rear sides of the bracket are provided with through grooves, the bottom of the bracket is fixedly connected with a plurality of supporting legs, a liquid collection device is provided on the left part of the bracket, and a detection tube is provided on the left part of the liquid collection device.
[0008] Furthermore, support plates are fixedly connected to both sides of the bottom of the shell, an extrusion plate is arranged inside the support plate, limit rods are slidably connected to both sides of the inner part of the extrusion plate, the limit rods are fixedly connected to the inner part of the support plate, a spring is arranged outside the limit rod, the spring is arranged on the upper part of the extrusion plate, the lower part of the extrusion plate is fixedly connected to a connecting rod, and the lower part of the connecting rod is fixedly connected to a base.
[0009] Furthermore, a controller is fixedly connected to the front right side of the analyzer.
[0010] Furthermore, the circular plate is slidably connected inside the through groove.
[0011] Furthermore, the fixing plate is slidably connected inside the sliding groove.
[0012] Furthermore, a handle is fixedly connected to the upper portion of the shell.
[0013] Furthermore, an observation window is hinged on the inner upper side of the analyzer.
[0014] The utility model has the following beneficial effects:
[0015] 1. In the utility model, the biological analyzer can be effectively fixed and the stability when carrying can be improved through the cooperation among the shell, analyzer, sliding block, turning handle, positioning block, box door, fixing block, locking screw and threaded rod.
[0016] 2. In the utility model, by cooperating among structures such as the bracket, the ear platform, the convex plate, the round rod, the through groove, the supporting leg and the liquid taking device, the test tube on the ear platform can be shaken to avoid stratification of the solution in the test tube due to precipitation, so that the sample is sucked more evenly and the error of the test data is reduced. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] Figure 1 A three-dimensional diagram of a portable SPR biomolecule interaction analysis device proposed by the utility model;
[0018] Figure 2This is a cross-sectional view of a portable SPR biomolecule interaction analysis device proposed by the utility model;
[0019] Figure 3 This is a schematic diagram of the structure of an analyzer for a portable SPR biomolecule interaction analysis device proposed in the utility model;
[0020] Figure 4 This is a schematic diagram of the bottom structure of a portable SPR biomolecule interaction analysis device proposed by the utility model;
[0021] Figure 5 This is a schematic diagram of the partial structure of a portable SPR biomolecule interaction analysis device proposed by the utility model.
[0022] Legend:
[0023] 1. Shell; 2. Handle; 3. Limit block; 4. Fixing block; 5. Locking screw; 6. Slide groove; 7. Fixing plate; 8. Positioning block; 9. Turning handle; 10. Base; 11. Threaded rod; 12. Analyzer; 13. Support plate; 14. Spring; 15. Extrusion plate; 16. Limit rod; 17. Slide rod; 18. Sliding block; 19. Observation window; 20. Liquid extraction device; 21. Detection tube; 22. Ear platform; 23. Controller; 24. Convex plate; 25. Motor; 26. Support leg; 27. Bracket; 28. Round rod; 29. Through groove; 30. Round plate; 31. Box door; 32. Connecting rod. DETAILED DESCRIPTION
[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0025] Reference Figure 1 and Figure 2 , an embodiment provided by the utility model:
[0026] A portable SPR biomolecule interaction analysis device comprises a housing 1, an analyzer 12 is arranged inside the housing 1, a positioning block 8 is fixedly connected to the outside of the housing 1, a threaded rod 11 is threadedly connected to the inside of the positioning block 8, a handle 9 is fixedly connected to the lower part of the threaded rod 11, a fixing plate 7 is arranged on the upper part of the threaded rod 11, a sliding block 18 is fixedly connected to the threaded rod 11, a sliding rod 17 is slidably connected to the outside of the sliding block 18, the sliding rod 17 is arranged inside the fixing plate 7, sliding grooves 6 are provided on both sides of the inside of the housing 1, a box door 31 is hinged on the housing 1, a limiting block 3 is fixedly connected to the upper right side of the box door 31, a fixing block 4 is fixedly connected to the upper right side of the housing 1, a locking screw 5 is threadedly connected to the inner part of the fixing block 4, and a shaking component is arranged inside the analyzer 12;
[0027] When the analyzer 12 needs to be carried, the analyzer 12 is placed inside the shell 1, and then the box door 31 is flipped over, and then the locking screw 5 on the fixing block 4 is screwed into the inside of the limit block 3 to fix the box door 31. The analyzer 12 is placed inside the shell 1, and then the box door 31 is flipped over, and then the locking screw 5 on the fixing block 4 is screwed into the inside of the limit block 3 to fix the box door 31. The fixing plate 7 is pushed to be placed above the analyzer 12, and then the handle 9 is turned. The handle 9 drives the threaded rod 11 on the positioning block 8 to pull the fixing plate 7 to move in the slide groove 6, and then the fixing plate 7 is slid by the slide rod 17 to enter the inside of the shell 1, thereby pressing and fixing the analyzer 12.
[0028] Reference Figure 1 , Figure 4 and Figure 5 The shaking assembly includes a bracket 27, which is fixedly connected to the left side of the inside of the analyzer 12. An ear platform 22 is arranged on the upper part of the bracket 27. The bottom of the ear platform 22 is rotatably connected to a round rod 28 through a bearing. The bottom of the round rod 28 passes through the bottom of the bracket 27 and is fixed with a convex plate 24. A motor 25 is fixed to the bottom of the bracket 27. The output shaft of the motor 25 is fixedly connected to the bottom of the convex plate 24. The front and rear sides of the ear platform 22 are fixedly connected with a round plate 30. The front and rear sides of the bracket 27 are provided with through grooves 29. The bottom of the bracket 27 is fixedly connected with a plurality of supporting legs 26. A liquid taking device 20 is arranged on the left part of the bracket 27. A detection tube 21 is arranged on the left part of the liquid taking device 20. The right side of the front of the analyzer 12 is fixedly connected with a controller 23.
[0029] When in use, the personnel puts the test tube in the card position of the ear platform 22, and then closes the cover body, sets the detection program on the control panel through the controller 23 and starts the device, and then the liquid taking device 20 can suck out the solution in the test tube in turn and put it into the corresponding detection tube 21. When all the detection tubes 21 are undergoing detection, the liquid taking device 20 can stop the liquid taking work and wait for the detection tube 21 to be detected before starting the liquid taking work. At this time, the motor 25 starts to work and can drive the convex plate 24 to rotate. The convex plate 24 can drive the ear platform 22 to shake at a uniform speed on the bracket 27 through the round rod 28. At the same time, the circular plate 30 is slidably connected to the inside of the through groove 29, and the shaking speed is moderate, neither too fast nor too slow, so that the static test tubes can be shaken. When the detection tubes 21 are emptied and ready for the next batch of detection, the motor 25 drives the ear platform 22 to slow down until the shaking stops, the ear platform 22 is reset, and the liquid taking device 20 continues to work.
[0030] Reference Figure 1 and Figure 2 The bottom sides of the shell 1 are fixedly connected with support plates 13, and an extrusion plate 15 is arranged inside the support plate 13. The inner sides of the extrusion plate 15 are slidably connected with limit rods 16, and the limit rods 16 are fixedly connected inside the support plate 13. A spring 14 is arranged outside the limit rod 16, and the spring 14 is arranged on the upper part of the extrusion plate 15. The lower part of the extrusion plate 15 is fixedly connected with a connecting rod 32, and the lower part of the connecting rod 32 is fixedly connected with the base 10;
[0031] When the housing 1 is placed, the base 10 pushes the connecting rod 32 to drive the extrusion plate 15 to move. The two ends of the extrusion plate 15 slide on the limit rod 16 to squeeze the spring 14 to achieve the buffering and shock absorption when the housing 1 is placed.
[0032] Reference Figure 1 , Figure 2 and Figure 5 The circular plate 30 is slidably connected to the inside of the through groove 29, the fixed plate 7 is slidably connected to the inside of the slide groove 6, the upper part of the housing 1 is fixedly connected to the handle 2, and the upper side of the analyzer 12 is hinged with an observation window 19;
[0033] The stationary test tube can be shaken, and the analyzer 12 can be pressed and fixed by sliding the fixing plate 7 inside the slide groove 6. The housing 1 can be conveniently carried by providing the handle 2, and the test tube detection inside the analyzer 12 can be observed by providing the observation window 19.
[0034] Working principle: When using this device, when the analyzer 12 needs to be carried, the analyzer 12 is placed inside the shell 1, and then the box door 31 is flipped over, and then the locking screw 5 on the fixing block 4 is screwed into the inside of the limit block 3 to fix the box door 31, and the fixing plate 7 is pushed to be placed above the analyzer 12, and then the handle 9 is turned. The handle 9 drives the threaded rod 11 on the positioning block 8 to pull the fixing plate 7 to move in the slide groove 6 to press and fix the analyzer 12. When placing the shell 1, the base 10 pushes the connecting rod 32 to drive the squeezing plate 15 to move, and the two ends of the squeezing plate 15 slide on the limit rod 16 to squeeze the spring 14 to achieve the buffering and shock absorption when the shell 1 is placed. When using it, the personnel puts the test tube in the card position of the ear platform 22, and then closes the cover body. After the controller 23 sets the detection program on the control panel and starts the device, the liquid taking device 20 can then suck out the solution in the test tube in turn and put it into the corresponding test tube 21. When all the test tubes 21 are undergoing detection, the liquid taking device 20 can stop the liquid taking work and wait for the test tube 21 to be detected before starting the liquid taking work again. At this time, the motor 25 starts to work and can drive the convex plate 24 to rotate. The convex plate 24 can drive the ear platform 22 to shake at a uniform speed on the bracket 27 through the round rod 28. At the same time, the round plate 30 is slidably connected to the inside of the through groove 29, so that the stationary test tubes can be shaken. When the test tubes 21 are emptied and ready for the next batch of tests, the motor 25 drives the ear platform 22 to slow down until the shaking stops, the ear platform 22 is reset, and the liquid taking device 20 continues to work.
[0035] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.
Claims
1. A portable SPR biomolecular interaction analysis device, comprising a housing (1), characterized in that: An analyzer (12) is arranged inside the shell (1), a positioning block (8) is fixedly connected to the outside of the shell (1), a threaded rod (11) is threadedly connected to the inside of the positioning block (8), a handle (9) is fixedly connected to the lower part of the threaded rod (11), a fixed plate (7) is arranged on the upper part of the threaded rod (11), a sliding block (18) is fixedly connected to the threaded rod (11), the outside of the sliding block (18) is slidably connected to a sliding rod (17), and the sliding rod (17) is arranged inside the fixed plate (7), sliding grooves (6) are provided on both sides of the inside of the shell (1), a door (31) is hinged on the shell (1), the upper right side of the door (31) is fixedly connected to a limiting block (3), the upper right side of the shell (1) is fixedly connected to a fixing block (4), the internal thread of the fixing block (4) is threadedly connected to a locking screw (5), and a shaking component is arranged inside the analyzer (12).
2. A portable SPR biomolecule interaction analysis device according to claim 1, characterized in that: The shaking assembly comprises a bracket (27), the bracket (27) being fixedly connected to the left side inside the analyzer (12), an ear platform (22) being arranged on the upper part of the bracket (27), the bottom of the ear platform (22) being rotatably connected to a round rod (28) via a bearing, the bottom of the round rod (28) passing through the bottom of the bracket (27) and being fixed with a convex plate (24), a motor (25) being fixed to the bottom of the bracket (27), an output shaft of the motor (25) being fixedly connected to the bottom of the convex plate (24), a round plate (30) being fixedly connected to the front and rear sides of the ear platform (22), a through groove (29) being provided on the front and rear sides of the bracket (27), a plurality of supporting legs (26) being fixedly connected to the bottom of the bracket (27), a liquid taking device (20) being arranged on the left part of the bracket (27), and a detection tube (21) being arranged on the left part of the liquid taking device (20).
3. A portable SPR biomolecule interaction analysis device according to claim 1, characterized in that: The bottom sides of the shell (1) are fixedly connected to support plates (13), an extrusion plate (15) is arranged inside the support plate (13), and limiting rods (16) are slidably connected to the inside of the extrusion plate (15) on both sides, the limiting rod (16) is fixedly connected to the inside of the support plate (13), and a spring (14) is arranged outside the limiting rod (16), and the spring (14) is arranged on the upper part of the extrusion plate (15). The lower part of the extrusion plate (15) is fixedly connected to a connecting rod (32), and the lower part of the connecting rod (32) is fixedly connected to the base (10).
4. A portable SPR biomolecule interaction analysis device according to claim 1, characterized in that: A controller (23) is fixedly connected to the right front side of the analyzer (12).
5. A portable SPR biomolecule interaction analysis device according to claim 2, characterized in that: The circular plate (30) is slidably connected inside the through groove (29).
6. A portable SPR biomolecule interaction analysis device according to claim 2, characterized in that: The fixing plate (7) is slidably connected inside the sliding groove (6).
7. A portable SPR biomolecule interaction analysis device according to claim 1, characterized in that: A handle (2) is fixedly connected to the upper portion of the shell (1).
8. A portable SPR biomolecule interaction analysis device according to claim 1, characterized in that: An observation window (19) is hingedly connected to the inner upper side of the analyzer (12).