Induced pluripotent stem cell culture device

Abstract

An induced pluripotent stem cell culture device comprises a base, a cell culture cabinet is fixedly connected to the outer wall of the upper side of the base, a lifting plate is slidably arranged in the base, universal wheels are installed at the four corners of the lower side wall of the lifting plate respectively, first sliding grooves are formed in the inner walls of the two sides of the cell culture cabinet respectively, and follow-up plates are slidably connected into the first sliding grooves; and a connecting column is fixedly connected between the follower plate and the lifting plate. Compared with the prior art, the cell culture cabinet has the advantages that through the arrangement of the second sliding grooves, the moving blocks, the connecting rods and the second shock absorption springs, the cell culture cabinet can have the shock absorption capacity, impact force transmitted from the road surface can be buffered and counteracted in the moving process, severe impact on cultured cells caused by bumping of the road surface is avoided, and the service life of the cell culture cabinet is prolonged. And through the arranged anti-skid assembly, the anti-skid pad can be tightly attached to the ground when moving is not needed, the contact area and friction force between the anti-skid pad and the ground are increased, the problem that sliding is likely to happen due to point contact between the universal wheels and the ground is solved, and the device is more stable and reliable.

Description

Technical Field

[0001] The utility model relates to the technical field of cell culture, in particular to an induced pluripotent stem cell culture device. Background Art

[0002] Induced pluripotent stem cells (iPS) are cells that have been reprogrammed into pluripotent stem cells by introducing specific transcription factors into terminally differentiated somatic cells. Cell reprogramming is the process by which differentiated cells are reversed under specific conditions, returning them to a totipotent state, either forming embryonic stem cell lines or further developing into new individuals.

[0003] After searching, the Chinese patent publication number CN216688165U discloses an induced pluripotent stem cell culture device, including a mobile culture cabinet, a stepper motor is installed on the back of the mobile culture cabinet, and the output end of the stepper motor passes through the mobile culture cabinet and is rotatably connected to it, the output end of the stepper motor is fixedly connected to a driving wheel, and a protective shell is installed on the outside of the stepper motor, the inner wall of the mobile culture cabinet is rotatably connected to a driven wheel, and the driving wheel and the driven wheel are connected by a transmission belt, the outer surface of the transmission belt is provided with a through hole, and the inner surface of the through hole is slidably connected to the driven wheel. There is a telescopic rod, the back of the telescopic rod is connected to the mounting plate, the outside of the telescopic rod is provided with a reset spring, and the two ends of the reset spring are respectively fixedly connected to the transmission belt and the mounting plate, the front of the telescopic rod is rotatably connected to the holding seat, and the bottom surface of the holding seat is provided with a connecting hole, the inside of the connecting hole is slidably connected to the trachea, and the top end of the trachea is connected to the bottom plate, the top surface of the mobile incubator is provided with a positioning hole, and the inside of the positioning hole is slidably connected to the work-shaped seat, the inside of the work-shaped seat is inlaid with a conveying pipe, and an observation mechanism is installed inside the mobile incubator.

[0004] The above-mentioned existing technical solutions have the following deficiencies: the mobile incubator will inevitably experience bumps when it needs to be moved, and the impact force of the road surface will cause severe impact on the cells inside the mobile incubator, seriously affecting the normal culture of the cells. Utility Model Content

[0005] In view of the above-mentioned deficiencies in the prior art, the present invention provides an induced pluripotent stem cell culture device to solve the problems raised in the above-mentioned background technology.

[0006] In order to achieve the above-mentioned purpose of the utility model, the technical solution adopted by the utility model is an induced pluripotent stem cell culture device, including a base, a cell culture cabinet is fixedly connected to the upper outer wall of the base, a lifting plate is slidingly provided in the base, and universal wheels are respectively installed at the four corners of the lower side wall of the lifting plate, and a first slide groove is respectively provided on the inner walls on both sides of the cell culture cabinet, a follower plate is slidably connected in the first slide groove, a connecting column is fixedly connected between the follower plate and the lifting plate, a first shock-absorbing spring is abutted between the follower plate and the upper side wall of the first slide groove, a shock-absorbing component is also provided inside the base, and anti-slip components are respectively provided on the outer walls on both sides of the base.

[0007] As an improvement: the shock absorbing assembly includes a second slide groove, a moving block, a connecting rod and a second shock-absorbing spring. Four second slide grooves distributed in a cross shape are opened on the upper inner wall of the base. The moving block is slidably connected in the second slide groove. A connecting rod is hinged on the bottom wall of the moving block. The other end of the connecting rod is hinged to the middle part of the upper side wall of the lifting plate. A second shock-absorbing spring is abutted between the moving block and a side wall of the second slide groove away from the center of the upper inner wall of the base.

[0008] As an improvement: the anti-slip component includes side panels, screws, anti-slip plates and handwheels. Side panels are fixedly connected to the outer walls on both sides of the base. Screws are threadedly inserted into the side panels. The lower end of the screw is rotatably connected to the anti-slip plate and the upper end is fixedly connected to the handwheel. An anti-slip pad is provided on the lower side wall of the anti-slip plate.

[0009] As an improvement: a shock absorber is installed at the center of the upper inner wall of the base, and the piston end of the shock absorber is fixedly connected to the lifting plate.

[0010] As an improvement: guide columns are slidably inserted on the side panels and located on the front and rear sides of the screw rod, and the lower ends of the guide columns are fixedly connected to the anti-slip plate.

[0011] Compared with the prior art, the present invention has the following beneficial effects:

[0012] 1. The second slide, moving block, connecting rod and second shock-absorbing spring can make the cell culture cabinet have the ability to absorb shock. When moving, it can buffer and offset the impact force transmitted from the road surface, avoiding the severe impact of road bumps on the cultured cells. The anti-slip component can make the anti-slip pad close to the ground when it does not need to move, increasing the contact area and friction with the ground, avoiding the problem of easy sliding caused by point contact between the universal wheel and the ground, and making it more stable and reliable. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the overall structure of an induced pluripotent stem cell culture device of the present invention;

[0014] Figure 2 This is a schematic diagram of the internal structure of the base of an induced pluripotent stem cell culture device of the present invention;

[0015] Figure 3 This is a schematic diagram of the structure of a shock-absorbing component of an induced pluripotent stem cell culture device of the present invention;

[0016] As shown in the figure:

[0017] 1. Base; 2. Cell culture cabinet; 1.1. Lifting plate; 1.2. Universal wheel; 1.3. First slide; 1.4. Follower plate; 1.5. Connecting column; 1.6. First shock-absorbing spring; 3. Shock-absorbing assembly; 4. Anti-slip assembly; 3.1. Second slide; 3.2. Moving block; 3.3. Connecting rod; 3.4. Second shock-absorbing spring; 4.1. Side panel; 4.2. Screw; 4.3. Anti-slip plate; 4.4. Handwheel; 1.7. Shock absorber; 4.5. Guide column. DETAILED DESCRIPTION

[0018] In order to make the technical means, creative features and purpose effects achieved by the present invention easier to understand, the present invention is further described below in conjunction with specific implementation methods.

[0019] In the description of this utility model, it should be noted that the terms "upper," "lower," "inner," "outer," "front," "back," "both sides," "one side," "the other side," and the like, indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely to facilitate the description of this utility model and simplify the description. They do not indicate or imply that the devices or components referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0020] In the description of this utility model, it should be noted that, unless otherwise expressly specified or limited, the terms "installed," "provided with," "connected," etc. should be understood in a broad sense. For example, "connected" can mean a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be internal communication between two components. Those skilled in the art will be able to understand the specific meanings of the above terms in this utility model based on the specific circumstances.

[0021] like Figure 1 and Figure 2The foldable plate 1.1 is provided with a plurality of movable plates 1.4 for supporting the movable plate 1.6 and the movable plate 1.7 for supporting the movable plate 1.8. The foldable plate 1.4 is provided with a plurality of movable plates 1.8 for supporting the movable plate 1.9. The foldable plate 1.5 is provided with a plurality of movable plates 1.9 for supporting the movable plate 1.8.

[0022] Specifically, such as Figure 3 As shown, an induced pluripotent stem cell culture device, the shock absorbing assembly 3 includes a second slide 3.1, a moving block 3.2, a connecting rod 3.3 and a second shock absorbing spring 3.4. Four second slides 3.1 distributed in a cross shape are opened on the upper inner wall of the base 1. The second slides 3.1 are slidably connected to the moving block 3.2. The bottom wall of the moving block 3.2 is hinged with a connecting rod 3.3. The other end of the connecting rod 3.3 is hinged to the middle of the upper side wall of the lifting plate 1.1. The moving block 3.2 abuts against a side wall of the second slide 3.1 away from the center of the upper inner wall of the base 1. There is a second shock-absorbing spring 3.4. When moving, the bumps of the road will cause the lifting plate 1.1 to move upward. Driven by the connecting rod 3.3, the moving block 3.2 will slide along the second slide groove 3.1 and squeeze the second shock-absorbing spring 3.4. The second shock-absorbing spring 3.4 buffers and offsets the impact force of the road, so that the impact force of the road cannot directly act on the cell culture cabinet 2, effectively preventing the bumps of the road from causing severe impact on the cultured cells. The four second shock-absorbing springs 3.4 distributed in a cross shape can disperse and buffer the impact force, thereby improving the shock absorption effect.

[0023] Specifically, such as Figure 1As shown, an induced pluripotent stem cell culture device, the anti-skid component 4 includes a side panel 4.1, a screw 4.2, an anti-skid plate 4.3 and a handwheel 4.4. The side panels 4.1 are fixedly connected to the outer walls of both sides of the base 1. The screw 4.2 is threadedly inserted on the side panel 4.1. The lower end of the screw 4.2 is rotatably connected to the anti-skid plate 4.3 and the upper end is fixedly connected to the handwheel 4.4. An anti-skid pad is provided on the lower side wall of the anti-skid plate 4.3. Rotating the handwheel 4.4 can drive the screw 4.2 to rotate. Since the screw 4.2 is threadedly connected to the side panel 4.1, the anti-skid plate 4.3 will be driven to move downward when the screw 4.2 rotates, so that the anti-skid pad on the bottom wall of the anti-skid plate 4.3 is close to the ground, thereby increasing the contact area with the ground and improving the friction, thereby preventing the universal wheel 1.2 from sliding due to point contact with the ground, and making it more stable and reliable.

[0024] Specifically, such as Figure 3 As shown, an induced pluripotent stem cell culture device is provided. A shock absorber 1.7 is installed at the center of the upper inner wall of the base 1. The piston end of the shock absorber 1.7 is fixedly connected to the lifting plate 1.1. The shock absorber 1.7 can provide a certain resistance to suppress the repeated lateral jumping of the first shock-absorbing spring 1.6 and the second shock-absorbing spring 3.4 after absorbing the shock, so that the lifting plate 1.1 can quickly stabilize after the bump.

[0025] Specifically, such as Figure 1 As shown, an induced pluripotent stem cell culture device has guide columns 4.5 slidably inserted on the side panel 4.1 and located on the front and rear sides of the screw 4.2. The lower ends of the guide columns 4.5 are fixedly connected to the anti-slide plate 4.3. The guide columns 4.5 can limit the anti-slide plate 4.3 to prevent it from rotating.

[0026] When the utility model is implemented, during movement, the bumps of the road surface will cause the lifting plate 1.1 to move upward. Driven by the connecting rod 3.3, the moving block 3.2 will slide along the second slide groove 3.1 and squeeze the second shock-absorbing spring 3.4. The second shock-absorbing spring 3.4 buffers and offsets the impact force of the road surface. At the same time, driven by the connecting column 1.5, the follower plate 1.4 will move upward along the first slide groove 1.3 and squeeze the first shock-absorbing spring 1.6. The first shock-absorbing spring 1.6 further buffers the impact force, so that the impact force of the road surface cannot directly act on the cell culture cabinet 2. The impact force will be buffered and offset by the first shock-absorbing spring 1.6 and the second shock-absorbing spring 3.4, effectively In order to prevent the cultured cells from being violently impacted by road bumps, the shock absorber 1.7 can provide a certain resistance to suppress the repeated sideways jumping of the first shock-absorbing spring 1.6 and the second shock-absorbing spring 3.4 after absorbing the shock, so that the lifting platform 1.1 can quickly stabilize after the bump. After moving to the destination, the hand wheel 4.4 is turned to drive the screw 4.2 to rotate. Since the screw 4.2 is threadedly connected to the side plate 4.1, the rotation of the screw 4.2 will drive the anti-skid plate 4.3 to move downward, so that the anti-skid pad on the bottom wall of the anti-skid plate 4.3 is close to the ground, increasing the contact area with the ground and improving the friction, preventing the universal wheel 1.2 from sliding due to point contact with the ground, and making it more stable and reliable.

[0027] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and improvements are intended to fall within the scope of the present invention. The scope of protection claimed in this invention is defined by the appended claims and their equivalents.

Claims

1. An induced pluripotent stem cell culture device, comprising a base (1), characterized in that: A cell culture cabinet (2) is fixedly connected to the upper outer wall of the base (1); a lifting plate (1.1) is slidably provided inside the base (1); universal wheels (1.2) are respectively installed at the four corners of the lower wall of the lifting plate (1.1); first slide grooves (1.3) are respectively provided on the inner walls on both sides of the cell culture cabinet (2); a follower plate (1.4) is slidably connected in the first slide groove (1.3); a connecting column (1.5) is fixedly connected between the follower plate (1.4) and the lifting plate (1.1); a first shock absorbing spring (1.6) is abutted between the follower plate (1.4) and the upper wall of the first slide groove (1.3); a shock absorbing component (3) is also provided inside the base (1); and anti-slip components (4) are respectively provided on the outer walls on both sides of the base (1).

2. The induced pluripotent stem cell culture device according to claim 1, characterized in that: The shock absorbing assembly (3) comprises a second slide groove (3.1), a moving block (3.2), a connecting rod (3.3) and a second shock absorbing spring (3.4); four second slide grooves (3.1) distributed in a cross shape are provided on the upper inner wall of the base (1); the moving block (3.2) is slidably connected in the second slide groove (3.1); a connecting rod (3.3) is hinged on the bottom wall of the moving block (3.2); the other end of the connecting rod (3.3) is hinged to the middle part of the upper wall of the lifting plate (1.1); and a second shock absorbing spring (3.4) is abutted between the moving block (3.2) and a side wall of the second slide groove (3.1) away from the center of the upper inner wall of the base (1).

3. The induced pluripotent stem cell culture device according to claim 1, characterized in that: The anti-skid assembly (4) comprises a side plate (4.1), a screw rod (4.2), an anti-skid plate (4.3) and a hand wheel (4.4); the side plates (4.1) are fixedly connected to the outer walls on both sides of the base (1); the screw rod (4.2) is threadedly inserted into the side plate (4.1); the lower end of the screw rod (4.2) is rotatably connected to the anti-skid plate (4.3) and the upper end is fixedly connected to the hand wheel (4.4); and an anti-skid pad is provided on the lower side wall of the anti-skid plate (4.3).

4. The induced pluripotent stem cell culture device according to claim 1, characterized in that: A shock absorber (1.7) is installed at the center of the upper inner wall of the base (1), and the piston end of the shock absorber (1.7) is fixedly connected to the lifting plate (1.1).

5. The induced pluripotent stem cell culture device according to claim 3, characterized in that: Guide pillars (4.5) are slidably inserted on the side plates (4.1) and located on the front and rear sides of the screw rod (4.2). The lower end of the guide column (4.5) is fixedly connected to the anti-slip plate (4.3).

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