Microsphere embolism simulation device and system

Abstract

The embodiment of the utility model provides a device and a system for simulating microsphere embolism, and relates to the field of medical experiment equipment. The microsphere embolism simulation device comprises a transparent cover plate and a bottom plate, the transparent cover plate is provided with a first arc-shaped groove, the bottom plate is provided with a second arc-shaped groove, the bottom plate and the transparent cover plate are spliced, so that the second arc-shaped groove and the first arc-shaped groove jointly define a circular blood vessel simulation channel, the transparent cover plate is adopted, the visibility is good, and the blood vessel simulation effect is good. Meanwhile, the cover plate and the bottom plate can be spliced and can be conveniently cleaned after being detached, that is, the blood vessel simulating channel is convenient to clean, the formed blood vessel simulating channel is circular and is closer to blood vessel simulation, and the blood vessel simulation effect is improved.

Description

Technical Field

[0001] The utility model relates to the field of medical experimental equipment, in particular to a simulated microsphere embolism device and a system. Background Art

[0002] At present, the incidence and mortality of malignant tumors such as hepatocellular carcinoma, lung cancer, gastric cancer, prostate cancer, uterine fibroids, etc. are increasing. For patients in the middle and late stages who are not suitable for resection, transarterial chemoembolization (TACE) with less trauma, clear effect and fewer complications is a preferred treatment method. TACE is to deliver anticancer drugs directly to the lesion site through the artery through a catheter with the assistance of angiography equipment, which can not only reduce the toxic side effects of drugs in the whole body, but also achieve a high concentration of chemotherapy drugs in the lesion site. Therefore, in addition to drug loading capacity, the embolization effect of microspheres is another important indicator to determine the effectiveness of treatment. Considering the cumbersomeness and high cost of animal experiments, in the initial research stage of microspheres, a simple, observable and reusable in vitro simulation device that mimics the physiological state of the human body is needed to help determine whether the embolic microspheres can achieve long-term complete embolization of the target blood vessels under the action of blood flow flushing, and to observe and compare the redistribution of embolic microspheres of different particle sizes in the blood vessels.

[0003] In the prior art, the in vitro embolization simulation device has poor visibility, which is not conducive to observing the embolization process of the microspheres. At the same time, the simulated blood flow channel of the in vitro embolization simulation device is difficult to clean, and the simulation effect of the blood vessel is poor. Utility Model Content

[0004] The utility model provides a simulated microsphere embolization device and system, which have good visibility and are conducive to observing the microsphere embolization process. At the same time, the simulated blood flow channel is easy to clean, thereby improving the simulation effect on the blood vessel.

[0005] The embodiments of the present invention can be implemented as follows:

[0006] In one aspect, the utility model provides a simulated microsphere embolization device, comprising:

[0007] A transparent cover plate, wherein the transparent cover plate is provided with a first arc-shaped groove; and

[0008] A bottom plate is provided with a second arc-shaped groove, and the bottom plate and the transparent cover plate are spliced ​​so that the second arc-shaped groove and the first arc-shaped groove jointly define a circular simulated blood vessel channel.

[0009] The beneficial effects of the simulated microsphere embolization device of the utility model embodiment include:

[0010] The utility model provides a simulated microsphere embolization device, which comprises a transparent cover plate and a bottom plate, wherein the transparent cover plate is provided with a first arcuate groove, the bottom plate is provided with a second arcuate groove, the bottom plate and the transparent cover plate are spliced ​​so that the second arcuate groove and the first arcuate groove jointly define a circular simulated blood vessel channel, and the transparent cover plate has good visibility, which is conducive to observing the embolization process of the microspheres, and at the same time, the cover plate and the bottom plate can be spliced, which is convenient for cleaning after disassembly, that is, the simulated blood vessel channel is easy to clean, and the formed simulated blood vessel channel is circular, which is closer to the simulation of the blood vessel, thereby improving the simulation effect of the blood vessel.

[0011] On the other hand, the utility model provides a simulated microsphere embolization system, including the simulated microsphere embolization device as above, the simulated microsphere embolization system includes a constant temperature liquid storage area, a liquid inlet area and a microvascular simulation area connected in sequence, wherein the microvascular simulation area includes the simulated microsphere embolization device;

[0012] The constant temperature liquid storage area includes a liquid reservoir;

[0013] The liquid inlet area also includes a sealing connection tube for injecting and connecting the microcatheter; the sealing connection tube is arranged between the liquid reservoir and the simulated microsphere embolization device and is used for sealing the microcatheter.

[0014] The utility model provides a simulated microsphere embolization system, which greatly improves the practicability of the simulated microsphere embolization system. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0016] Figure 1 A schematic plan view of a simulated microsphere embolization device provided in an embodiment of the utility model;

[0017] Figure 2 for Figure 1 A schematic cross-sectional view of a simulated microsphere embolic device at section 311 before splicing is provided;

[0018] Figure 3 for Figure 1 A schematic cross-sectional view of a simulated microsphere embolic device after splicing at section 311 is provided;

[0019] Figure 4 A connection diagram of a simulated microsphere embolization system provided in an embodiment of the utility model.

[0020] Icons: 1-constant temperature liquid storage area; 11-liquid reservoir; 2-liquid inlet area; 21-delivery pump; 22-sealed connecting pipe; 3-microvascular simulation area; 31-imitation blood vessel channel; 311-cross-sectional position of imitation blood vessel channel; 32-fastener; 33-transparent cover; 331-embedded protrusion; 332-first arc-shaped groove; 34-bottom plate; 341-embedded groove; 342-second arc-shaped groove; 35-sealant; 36-sealing groove. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Generally, the components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0022] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0023] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0024] In the description of the present utility model, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when used. It is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present utility model.

[0025] In addition, the terms “first”, “second”, etc., if used, are merely used to distinguish between the descriptions and should not be understood as indicating or implying relative importance.

[0026] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0027] Most of the current in vitro embolization simulation devices rely on expensive microfluidic chips. Not only are the chips expensive and difficult to manufacture and use in large quantities, but the chips also have poor visibility, making it difficult to observe the embolization process of the microspheres. At the same time, the structural design of the chip makes it difficult to simulate the embolization of the microspheres in the capillaries of the main target blood vessels or lesion organs in actual embolization surgery, and it is difficult to disassemble and clean. In summary, the existing devices have poor authenticity in simulating the human body environment, and are limited in their use in testing the embolization effects of microspheres with a wide range of particle sizes in the human body.

[0028] In view of this, the inventors designed a new in vitro simulated microsphere embolization device, which will be described in detail below.

[0029] The embodiment of the utility model provides a simulated microsphere embolization device, Figure 1 A schematic plan view of a simulated microsphere embolization device provided in an embodiment of the utility model. Figure 2 for Figure 1 A schematic cross-sectional view of a simulated microsphere embolic device at section 311 before splicing is provided. Figure 3 for Figure 1 A schematic cross-sectional view of the simulated microsphere embolic device after splicing at section 311 is provided, see Figure 1 to Figure 3 The simulated microsphere embolization device includes a transparent cover plate 33 and a bottom plate 34, the transparent cover plate 33 is provided with a first arc-shaped groove 332, the bottom plate 34 is provided with a second arc-shaped groove 342, the bottom plate 34 and the transparent cover plate 33 are spliced ​​so that the second arc-shaped groove 342 and the first arc-shaped groove 332 jointly define a circular simulated blood vessel channel 31, wherein the inner wall of the first arc-shaped groove 332 and the inner wall of the second arc-shaped groove 342 are smooth.

[0030] In the embodiment of the utility model, a transparent cover plate 33 is used. Its material is transparent and has good visibility, which is conducive to observing the embolization process of the microspheres. At the same time, the transparent cover plate 33 and the bottom plate 34 can be spliced ​​together, which is convenient for cleaning after disassembly. In other words, the simulated blood vessel channel 31 is easy to clean; at the same time, the simulated blood vessel channel 31 composed of the first arc-shaped groove and the second arc-shaped groove is circular, which is closer to the simulation of the blood vessel, thereby improving the simulation effect of the blood vessel.

[0031] The transparent cover plate 33 may be made of an acrylic plate, and the bottom plate 34 may be made of stainless steel. The transparent cover plate 33 and the bottom plate 34 are spliced ​​to form a rectangular parallelepiped structure, which can be understood as a blood vessel simulation component.

[0032] In this embodiment, the cross section of the first arc-shaped groove 332 along the first direction is in an arc shape, specifically a semicircular arc shape, and the cross section of the second arc-shaped groove 342 along the first direction is also in a semicircular arc shape, wherein the first direction is perpendicular to the plane where the simulated microsphere embolization device is located, and is perpendicular to the extension direction of the simulated blood vessel channel 31. It should be noted that, if Figure 2 For example, the first direction can be understood as Figure 2 Thus, after the transparent cover plate 33 and the bottom plate 34 are spliced, the first arc-shaped groove 332 and the second arc-shaped groove 342 form a simulated circular blood vessel channel, which is closer to the simulation of the blood vessel. The plane where the simulated microsphere embolization device is located can be understood as the rectangular plane of the blood vessel simulation component (such as Figure 2 shown).

[0033] In addition, it should be noted that Figure 2 As shown, in order to enhance the firmness of the transparent cover plate 33 and the bottom plate 34 after being spliced, the simulated microsphere embolization device also includes a fastener 32. The fastener 32 can be a screw that penetrates the transparent cover plate 33 and the bottom plate 34 to fasten the transparent cover plate 33 and the bottom plate 34.

[0034] When the circular blood vessel channel needs to be cleaned, the fastener is removed to facilitate cleaning of the first arc-shaped groove 332 and the second arc-shaped groove 342, thereby achieving the purpose of reusability of the blood vessel simulation component.

[0035] In order to facilitate the transparent cover plate 33 to be positioned at the corresponding position of the bottom plate 34, the first arc-shaped groove 332 and the second arc-shaped groove 342 form a simulated circular blood vessel channel, such as Figure 2 As shown, the transparent cover plate 33 has an engaging protrusion 331, the engaging protrusion 331 is provided with a first arc-shaped groove 332, the bottom plate 34 is provided with an engaging groove 341 matching the engaging protrusion 331, the engaging protrusion 331 is engaged in the engaging groove 341, the bottom wall of the engaging groove 341 is provided with a second arc-shaped groove 342, the engaging protrusion 331 matches the engaging groove 341, and it should be noted that the protruding thickness of the engaging protrusion 331 is equal to the recessed thickness of the engaging groove 341.

[0036] When the transparent cover plate 33 and the bottom plate 34 are tightly fitted together in the embodiment of the utility model, the engaging protrusion 331 is tightly fitted with the engaging groove 341, and at the same time, the first arc-shaped groove 332 and the second arc-shaped groove 342 form a tightly fitted imitation blood vessel channel 31. In this way, the transparent cover plate 33 and the bottom plate 34 are tightly fitted together by utilizing the setting of the engaging protrusion 331 and the engaging groove 341, and the sealing of the circular blood vessel channel can be enhanced.

[0037] In an optional embodiment of the present invention, Figure 3 As shown, the protruding height H of the engaging protrusion 331 and the cross-sectional radius R of the first arc-shaped groove 332 satisfy: H≥R, so as to ensure that the circular blood vessel channel of the cover plate is not easily deformed during the fixing process, thereby increasing the service life of the blood vessel simulation component.

[0038] In order to improve the sealing performance of the simulated blood vessel channel 31, Figure 2 and Figure 3As shown, the simulated microsphere embolization device also includes a sealant 35, which is arranged on at least one side of the simulated blood vessel channel 31 along the second direction, wherein the second direction is perpendicular to the extension direction of the simulated blood vessel channel 31, and the sealant 35 is arranged between the transparent cover plate 33 and the bottom plate 34, and is used to bond the transparent cover plate 33 and the bottom plate 34.

[0039] In an optional embodiment, if Figure 2 As shown, the sealant 35 is disposed on both sides of the simulated blood vessel channel 31 along the second direction; in other optional embodiments, the sealant 35 may be disposed only on any one side of the simulated blood vessel channel 31 along the second direction, and the present utility model does not impose any limitation thereto.

[0040] It should be noted that the sealant 35 can be a continuous sealant strip extending along both sides of the simulated blood vessel channel 31, or can include a plurality of sealant points or sealant segments spaced apart and arranged in intervals. The present invention does not limit the plane shape of the sealant.

[0041] In addition, when both sides of the simulated blood vessel channel 31 are provided with sealants 35 and are arranged discontinuously, the sealants 35 on both sides can be arranged oppositely or staggered. Here, oppositely arranged can be understood as the projection of the sealant 35 on one side along the second direction can overlap with the sealant 35 on the other side, and staggered arranged can be understood as the projection of the sealant 35 on one side along the second direction can not overlap with the sealant 35 on the other side. In this way, the amount of sealant used can be saved, and the sealing effect can be maximized.

[0042] In another optional embodiment, at least one of the transparent cover plate 33 and the bottom plate 34 is provided with a sealing groove, and the sealing groove and the sealant 35 at least partially overlap in a direction perpendicular to the plane where the simulated microsphere embolization device is located.

[0043] In this embodiment, if Figure 2 As shown, a sealing groove 36 is provided on the bottom plate 34, and a sealant 35 is provided in the sealing groove 36, so that when the transparent cover plate 33 and the bottom plate 34 are tightly fitted, the sealant 35 can be squeezed and set in the sealing groove 36 so that no gap is generated between the transparent cover plate 33 and the bottom plate 34.

[0044] In other optional embodiments, the sealing groove 36 can be provided on the transparent cover plate 33, and the present invention does not impose any limitation thereto. It is only necessary to ensure that the sealing groove and the sealant at least partially overlap in a direction perpendicular to the plane where the simulated microsphere embolization device is located, so that the sealant can be contained in the sealing groove, thereby improving the sealing between the transparent cover plate 33 and the bottom plate 34.

[0045] In order to ensure that the visualization of the embolization process of embolic microspheres of different particle sizes is more ideal, the vascular-mimicking channel 31 provided in the embodiment of the utility model has an outlet and an inlet, such as Figure 1 As shown, the inner diameter at the inlet is D1, the inner diameter at the outlet is D2, and the inner diameter of at least part of the simulated blood vessel channel 31 in the axial direction from the inlet to the outlet decreases linearly stepwise. That is, in the direction of liquid flow along the simulated blood vessel channel 31, at least a portion of the length of the simulated blood vessel channel 31 decreases linearly.

[0046] Optionally, the inner diameter D1 of the inlet and the inner diameter D2 of the outlet satisfy: 1.9 mm ≤ D1 ≤ 2.1 mm, 0.04 mm ≤ D2 ≤ 0.06 mm. In this way, the in vitro simulation requirements of different embolic microsphere particle sizes can be met.

[0047] For example, the inner diameter D1 of the inlet may be 1.9 mm, 2 mm, or 2.1 mm, and the inner diameter D2 of the outlet may be 0.04 mm, 0.05 mm, or 0.06 mm.

[0048] For example, in some embodiments, the inner diameter of the entire simulated blood vessel channel 31 in the axial direction from the inlet to the outlet may decrease linearly and gradually.

[0049] In this embodiment, the simulated blood vessel channel 31 includes a first pipe, a second pipe and a third pipe that are sequentially connected from the inlet to the outlet. It should be noted that for the understanding of the first pipe, the second pipe and the third pipe, please refer to Figure 1 In the simulated blood vessel channel 31 from one inlet to one outlet in the simulated microsphere embolization device, the simulated microsphere embolization device is first divided into L1 area, L2 area and L3 area in the direction from the inlet to the outlet. The widths of these three areas are roughly equal. Therefore, the partial channel of a simulated blood vessel channel 31 in the L1 area is called the first channel, and the partial channel of the simulated blood vessel channel 31 in the L2 area is called the second channel. Similarly, the partial channel of the simulated blood vessel channel 31 in the L3 area is called the third channel.

[0050] Here, the degree of winding may be understood as the number and degree of winding of the first pipe, the second pipe, or the third pipe.

[0051] In an optional embodiment, the first conduit, the second conduit, and the third conduit may have the same degree of winding. Thus, when the inner diameter of the simulated blood vessel channel 31 gradually decreases from the inlet to the outlet, all embolic microspheres with particle sizes between D2 and D1 may be evenly distributed in the simulated microsphere embolization device of this embodiment, thereby facilitating the observation of embolic simulation conditions of microspheres of all particle sizes.

[0052] In another optional embodiment, the degree of winding of the first pipe may be greater than that of the second pipe or the third pipe, wherein the inner diameter of the first pipe is greater than the inner diameter of the second pipe and the inner diameter of the third pipe, so that the embolic microspheres with smaller particle sizes can be located in the L2 area, i.e., the central area, of the simulated microsphere embolization device, which can facilitate the observation of the embolic simulation of the embolic microspheres with smaller particle sizes.

[0053] In another optional embodiment, the winding degree of the second pipe is greater than that of the third pipe or the first pipe, so that the embolic microspheres with particle sizes in the middle section between D2 and D1 can be distributed as much as possible in the L2 area of ​​the simulated microsphere embolic device in this embodiment, that is, located in the center of the entire simulated microsphere embolic device for easy observation.

[0054] In another optional embodiment, the winding degree of the third pipe is greater than that of the second pipe or the first pipe, so that the embolic microspheres with larger particle sizes can be located in the L2 area, i.e., the central area, of the simulated microsphere embolization device, which can facilitate the observation of the embolic simulation of the embolic microspheres with larger particle sizes.

[0055] It should be noted that the embolic microspheres with smaller particle sizes in the above embodiments refer to microspheres with a particle size smaller than (D1+D2) / 2, and the embolic microspheres with larger particle sizes refer to microspheres with a particle size larger than (D1+D2) / 2.

[0056] The specific number of winding bends and the degree of bending of the first conduit, the second conduit or the third conduit can be set according to actual conditions, so as to facilitate the embolic microspheres of a specific particle size to be observed to be located in the center of the entire simulated microsphere embolic device.

[0057] In addition, in some embodiments, the simulated blood vessel channel 31 includes a plurality of sub-channels connected in sequence, and the inner diameter change rate of at least one of the sub-channels is smaller than the inner diameter change rate of another sub-channel. That is to say, there are two sub-channels with different rates of change of inner diameter reduction. For example, the inner diameter change rate is larger in the sub-channel with a smaller degree of winding, and the inner diameter change rate is smaller in the sub-channel with a larger degree of winding. This can meet the actual design requirements of the simulated blood vessel channel.

[0058] In an optional embodiment, there is at least one sub-channel with a constant inner diameter between two non-adjacent sub-channels.

[0059] For example, the artificial blood vessel channel 31 includes four sub-channels connected in sequence, and the inner diameters of the four sub-channels connected in sequence decrease along the axial direction from the entrance to the exit of the artificial blood vessel channel 31. The inner diameter change rate of one sub-channel is smaller than the inner diameter change rate of another sub-channel. Alternatively, the inner diameter change rates of three sub-channels are smaller than the inner diameter change rate of another sub-channel, and there is a sub-channel with a constant inner diameter and a sub-channel with a changing inner diameter between two non-adjacent sub-channels, or there are two sub-channels with constant inner diameters between two non-adjacent sub-channels.

[0060] The inner diameter change rate here can be understood as the speed at which the inner diameter of the sub-channel decreases along the same length in the axial direction. The larger the inner diameter change rate, the larger the inner diameter of the sub-channel decreases along the same length in the axial direction; the smaller the inner diameter change rate, the smaller the inner diameter of the sub-channel decreases along the same length in the axial direction.

[0061] It should be noted that the vascular-mimicking channel 31 may have primary branches, secondary branches, or multiple branches, with a certain number of branches at each level. In the present embodiment, the vascular-mimicking channel 31 has three levels of branches, with a total of six channels, to simulate the bionic distribution of blood vessels in vivo. When there are more levels of branches or a larger number of branches, the pressure relief effect during the embolism test is better. The better pressure relief effect can be understood as when one of the branch channels is blocked, the liquid can flow out of the branch channel, thereby preventing blood pressure from affecting the microsphere test results.

[0062] In addition, this embodiment also provides a simulated microsphere embolization system, including the simulated microsphere embolization device provided above, such as Figure 4 As shown, Figure 4 A connection diagram of a simulated microsphere embolization system provided in an embodiment of the utility model, wherein the simulated microsphere embolization system includes a constant temperature liquid storage area 1, a liquid inlet area 2 and a microvascular simulation area 3 connected by a catheter to ensure the sealing of the simulated blood vessel pathway.

[0063] Specifically, the constant temperature liquid storage area 1 includes a liquid reservoir 11, which can be understood as a partial structure of a constant temperature water bath to provide a constant temperature environment. The temperature of the constant temperature water bath is set to 37°C. The liquid reservoir 11 is used to contain a simulated blood flow medium, which can be a phosphate buffer solution or simulated body fluid or 0.9% normal saline.

[0064] Among them, a delivery pump 21 and a sealed connecting tube 22 are distributed in the liquid inlet area 2. In order to facilitate the simulation of blood flow and test the influence of blood flow on the embolization process, the delivery pump 21 can use a constant flow pump. The flow rate range set by the delivery pump 21 can be 0.1-1mL / min. The delivery pump 21 can transfer the simulated blood flow medium in the reservoir 11 to the entrance of the simulated blood vessel channel in the simulated microsphere embolization device. The flow rate of the simulated blood flow medium can be adjusted and changed by the delivery pump 21; the sealed connecting tube 22 is a pipeline with a Luer connector, and the right end of the delivery pump 21 is connected to the microvascular simulation area 3 through the sealed connecting tube 22 with a Luer connector;

[0065] The microvascular simulation area 3 includes a simulated microsphere embolization device, which includes a simulated blood vessel channel 31 formed by a transparent cover plate 33 and a bottom plate 34 .

[0066] That is to say, during the simulated microsphere embolization test, the microcatheter can be superselected to the lesion area of ​​the simulated vascular channel 31 of the microvascular simulation area 3 through the sealed connecting tube of the Luer connector, and the embolic microspheres can be delivered to the blood vessels in the lesion area through the microcatheter to achieve precise embolization; at the same time, due to the sealed design of the sealed connecting tube of the microcatheter, the embolic microspheres and the simulated blood flow medium in the simulated vascular channel 31 can be prevented from flowing back and overflowing.

[0067] In addition, if Figure 4 As shown, the outlet of the simulated blood vessel channel 31 in the microvascular simulation area 3 is connected to the reservoir 11 in the constant temperature liquid storage area 1 through a pipeline, so as to ensure that the simulated blood flow medium in the simulated blood vessel channel 31 can flow back into the reservoir 11, thereby improving the utilization rate of the simulated blood flow medium.

[0068] The working principle of the simulated microsphere embolization system provided in this embodiment is:

[0069] Turn on the constant temperature water bath, and turn on the constant flow pump after reaching the set temperature, set the flow rate, and when the simulated blood flow medium fills the entire artificial blood vessel channel 31, superselect the microcatheter corresponding to the specifications of the microspheres used at the microsphere injection port (i.e., the entrance of the sealed connecting tube 22) to the target blood vessel position, then connect the suspension of microspheres and contrast agent to the microcatheter, and pulse-inject the microspheres at a rate of 1 mL / min, and observe and record the amount of microspheres, embolization position and embolization effect.

[0070] In summary, on the one hand, the utility model provides a simulated microsphere embolization device using a transparent cover plate 33, which has good visibility and is conducive to observing the microsphere embolization process. At the same time, the cover plate and the bottom plate 34 can be spliced, which is convenient for cleaning after disassembly. In other words, the simulated blood vessel channel 31 is easy to clean, and the composed simulated blood vessel channel 31 is circular, which is closer to the simulation of the blood vessel, thereby improving the simulation effect of the blood vessel.

[0071] At the same time, the simulated microsphere embolization device realizes the sealing of the vascular pathway, the simulation of blood flow flushing and the visualization of the embolization process. The gradient inner diameter design and the multi-level branch design of the simulated vascular channel 31 can observe the embolization effect of 50μm-1300μm microspheres and the redistribution of microspheres in blood vessels, and can realize the embolization of the capillaries of the main target blood vessels or diseased organs in the actual embolization surgery by simulating microspheres.

[0072] On the other hand, the utility model provides a simulated microsphere embolization system, which not only improves the recycling of simulated blood flow medium, but also greatly enhances the practicality of the simulated microsphere embolization system by designing the combination of simulated microsphere embolization devices in the constant temperature liquid storage area, the liquid inlet area and the microvascular simulation area.

[0073] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the utility model should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. A simulated microsphere embolization device, characterized in that: include: A transparent cover plate, wherein the transparent cover plate is provided with a first arc-shaped groove; as well as A bottom plate is provided with a second arc-shaped groove, and the bottom plate and the transparent cover plate are spliced ​​so that the second arc-shaped groove and the first arc-shaped groove jointly define a circular simulated blood vessel channel.

2. The simulated microsphere embolization device according to claim 1, characterized in that: The transparent cover plate has an engaging protrusion, and the engaging protrusion is provided with the first arc-shaped groove; The bottom plate is provided with an embedding groove, the embedding protrusion is embedded in the embedding groove, and the bottom wall of the embedding groove is provided with the second arc-shaped groove.

3. The simulated microsphere embolization device according to claim 2, characterized in that: The cross section of the first arc-shaped groove along the first direction is in the shape of an arc, wherein the first direction is perpendicular to the plane where the simulated microsphere embolization device is located and perpendicular to the extension direction of the simulated blood vessel channel; The protruding height H of the engaging protrusion and the cross-sectional radius R of the first arc-shaped groove satisfy: H≥R.

4. The simulated microsphere embolization device according to claim 1, characterized in that: The simulated microsphere embolization device further comprises a sealant, and the sealant is arranged on at least one side of the simulated blood vessel channel along a second direction; wherein the second direction is perpendicular to the extension direction of the simulated blood vessel channel; The sealant is arranged between the transparent cover plate and the bottom plate, and is used for bonding the transparent cover plate and the bottom plate.

5. The simulated microsphere embolization device according to claim 4, characterized in that: At least one of the transparent cover plate and the bottom plate is provided with a sealing groove, and the sealing groove and the sealant at least partially overlap in a direction perpendicular to the plane where the simulated microsphere embolization device is located.

6. The simulated microsphere embolization device according to claim 1, characterized in that: The simulated blood vessel channel has an outlet and an inlet, and the inner diameter of at least a portion of the simulated blood vessel channel in the axial direction from the inlet to the outlet decreases linearly and gradually; Alternatively, the simulated blood vessel channel has an outlet and an inlet, and an inner diameter D1 of the inlet and an inner diameter D2 of the outlet satisfy: 1.9 mm ≤ D1 ≤ 2.1 mm, 0.04 mm ≤ D2 ≤ 0.06 mm.

7. The simulated microsphere embolization device according to claim 6, characterized in that: The inner diameter of the entire simulated blood vessel channel in the axial direction from the inlet to the outlet is linearly and gradually reduced, and the simulated blood vessel channel includes a first pipe, a second pipe and a third pipe which are sequentially connected along the inlet toward the outlet; The first pipeline, the second pipeline and the third pipeline have the same degree of winding; or, the degree of winding of the first pipeline is greater than the degree of winding of the second pipeline or the third pipeline; or, the degree of winding of the third pipeline is greater than the degree of winding of the second pipeline or the first pipeline; or, the degree of winding of the second pipeline is greater than the degree of winding of the third pipeline or the first pipeline.

8. The simulated microsphere embolization device according to claim 6, characterized in that: The blood vessel-imitation channel includes a plurality of sub-channels connected in sequence; The inner diameter change rate of at least one of the sub-channels is smaller than the inner diameter change rate of another sub-channel; And / or, there is at least one sub-channel with a constant inner diameter between two non-adjacent sub-channels.

9. The simulated microsphere embolization device according to claim 1, characterized in that: The simulated microsphere embolism device also includes a fastener, which penetrates through the transparent cover plate and the bottom plate at the same time to fasten the transparent cover plate and the bottom plate.

10. A simulated microsphere embolization system, comprising the simulated microsphere embolization device according to any one of claims 1 to 9, characterized in that: The simulated microsphere embolization system comprises a constant temperature liquid storage area, a liquid inlet area and a microvascular simulation area which are connected in sequence, wherein the microvascular simulation area comprises the simulated microsphere embolization device; The constant temperature liquid storage area includes a liquid reservoir; The liquid inlet area also includes a sealing connection tube for injection connection microcatheter; the sealing connection tube is arranged between the liquid reservoir and the simulated microsphere embolization device, and is used to seal the microcatheter.

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