Liquid chromatograph-mass spectrometer mechanism for bioequivalence research

Abstract

The utility model discloses a liquid chromatograph-mass spectrometer mechanism for bioequivalence research, which structurally comprises a positioning frame, a main machine, detection pieces, a heat dissipation end, a pushing plate and a constant temperature placer, the bottom layer in the positioning frame is perpendicular to the main machine, and a power line of the main machine is buried in the positioning frame and is electrically connected with the detection piece at the upper end. The heat dissipation end and the top of the detection piece are of an integrated structure, the pushing disc is embedded in the lower middle area of the surface of the detection piece, and the constant-temperature placing device is installed on the left side of the positioning frame and is in interval fit with the detection piece. According to the utility model, on the basis of the constant-temperature placer arranged on the positioning frame, the positions of a plurality of groups of containers bearing related liquid phases can be positioned through the vertical pieces on the parallel plates, so that the flow of frequent running can be saved, and meanwhile, the temperature of the liquid phase containers on the vertical pieces can be controlled according to the constant-temperature blocks; and the unstable condition of related liquid phases caused by low temperature or high temperature influence is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatography-mass spectrometry analysis, in particular to a liquid chromatography-mass spectrometry instrument mechanism used for bioequivalence research. Background Art

[0002] Bioequivalence study is a scientific and technological method to determine the critical point, limit or potential ecological risk that may exist in a substance, physical condition or ecosystem. The liquid substance studied is in liquid state and there is only liquid in the current system.

[0003] The chromatographic mass spectrometer used in the bioequivalence study is a product of the close integration of three modern technologies: chromatography, mass spectrometry and computer technology. It can effectively perform quantitative measurement and anti-label detection on liquid substances. It has the characteristics of stable performance, high accuracy and simple operation.

[0004] However, the following defects still exist: since the current chromatography-mass spectrometry instrument lacks a stationary liquid phase carrier, after completing the detection of a single liquid phase, the operator needs to move the current liquid phase to a specific storage area for placement, and then conduct detection of other liquid phases. Therefore, after a series of moving, picking, placing, and operating processes, a lot of operating time will be wasted, which will lead to a reduction in the detection efficiency of the relevant liquid phase. Utility Model Content

[0005] In view of the above problems, the utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research.

[0006] In order to achieve the above-mentioned purpose, the utility model is realized through the following technical scheme: a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research, whose structure includes: a positioning frame, a mainframe, a detection part, a heat dissipation end, a push plate, and a constant temperature placer. The bottom layer inside the positioning frame is perpendicular to the mainframe, the power cord of the mainframe is buried inside the positioning frame and is electrically connected to the upper detection part, the heat dissipation end and the top of the detection part are an integrated structure, the push plate is embedded in the middle and lower area of ​​the surface of the detection part, the constant temperature placer is installed on the left side of the positioning frame and is spaced with the detection part, and the lower end of the constant temperature placer is electrically connected to the mainframe.

[0007] Furthermore, the constant temperature placement device is provided with a constant temperature block, a protective cover, an adjusting button, an adsorption frame, a parallel plate, and a vertical member. The edge of the constant temperature block carries a protective cover, the adjusting button passes through the side of the protective cover and is electrically connected to the constant temperature block, the adsorption frame is arranged above the adjusting button and is fixedly connected to the top of the protective cover and covers the upper and middle part of the constant temperature block, the parallel plate and the constant temperature block are perpendicular to each other, and the vertical member is embedded in the surface part of the parallel plate.

[0008] Furthermore, the vertical member is provided with an insert block, a bonding layer, a limit frame, a groove, and a jacket. The insert block is welded to the lower end of the limit frame through the bonding layer. The limit frame and the bonding layer are an integrated structure. The groove is opened inside the limit frame, and the jacket is vertically fixed to the inner center of the limit frame through the groove.

[0009] Furthermore, the jacket is provided with a metal block, an identification ring, a labeling layer, and a rubber body. The metal block and the identification ring are perpendicular to each other, the labeling layer and the surface layer of the identification ring are an integrated structure, and the rubber body penetrates the center point area of ​​the identification ring and coincides with the center of the metal block.

[0010] Furthermore, the thermostatic block is consistent with the shape of the protective cover, the adjustment button is circular, the width of the adsorption frame is smaller than the width of the protective cover, and the parallel plate is solid and has multiple square slots.

[0011] Furthermore, three inserting blocks are provided at the lower end of the limiting frame, the bonding layer is in a polished and flat state, and there is a distance between the inner wall of the groove and the jacket.

[0012] Furthermore, the center of the metal block contains a circular vertical groove, and the diameter of the identification ring is larger than the diameter of the rubber body and has flexibility. Beneficial Effects

[0013] Compared with the prior art, the utility model has the following beneficial effects:

[0014] 1. The utility model is based on a constant temperature placer installed on a positioning frame. It can position multiple groups of containers carrying related liquid phases through vertical parts on parallel plates, so that it can save frequent running processes. At the same time, the temperature of the liquid phase container on the vertical part can be controlled according to the constant temperature block to avoid the instability of the related liquid phase caused by low or high temperature.

[0015] 2. After the utility model is further improved through the jacket of the vertical member, it is based on the overlap of the metal block with the bottom layer of the limit frame, so that the temperature of the metal block can be quickly affected by the temperature of the constant temperature block, so that the liquid phase temperature of the container inside the rubber body can be quickly controlled, thereby improving the efficiency of temperature control. At the same time, the rubber body can improve the vertical fixity of the origin of the liquid phase container to prevent shaking and falling. Furthermore, the identification ring on the edge of the rubber body can mark the name of the liquid phase through the labeling layer, thereby improving the subsequent differentiation efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The utility model is a schematic diagram of the structure of a liquid chromatography-mass spectrometry instrument for bioequivalence research.

[0017] Figure 2 The utility model is a three-dimensional structural schematic diagram of an improved constant temperature placement device.

[0018] Figure 3 The utility model is a three-dimensional structural schematic diagram of an improved vertical member.

[0019] Figure 4 The utility model is a three-dimensional structural schematic diagram of an improved jacket.

[0020] In the figure: positioning frame-1, main machine-2, detection part-3, heat dissipation end-4, push plate-5, constant temperature placer-6, constant temperature block-61, protective cover-62, adjustment button-63, adsorption frame-64, parallel plate-65, vertical part-66, plug-in block-661, bonding layer-662, limit frame-663, groove-664, jacket-665, metal block-a1, identification ring-a2, labeling layer-a3, rubber body-a4. DETAILED DESCRIPTION

[0021] The technical solution of the utility model will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the utility model, rather than all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0022] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance. Example

[0023] like Figure 1-Figure 4 As shown, the utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research.

[0024] See also Figure 1The utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research, including: a positioning frame 1, a mainframe 2, a detection component 3, a heat dissipation end 4, a push plate 5, and a constant temperature placement device 6. The bottom layer inside the positioning frame 1 is perpendicular to the mainframe 2, the power line of the mainframe 2 is buried inside the positioning frame 1 and is electrically connected to the upper detection component 3, the heat dissipation end 4 and the top of the detection component 3 are an integrated structure, the push plate 5 is embedded in the middle and lower area of ​​the surface of the detection component 3, the constant temperature placement device 6 is installed on the left side of the positioning frame 1 and is spaced with the detection component 3, and the lower end of the constant temperature placement device 6 is electrically connected to the mainframe 2.

[0025] See also Figure 2 The utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research, comprising: the constant temperature placement device 6 is provided with a constant temperature block 61, a protective cover 62, an adjusting button 63, an adsorption frame 64, a parallel plate 65, and a vertical member 66. The edge of the constant temperature block 61 carries the protective cover 62, the adjusting button 63 penetrates the side of the protective cover 62 and is electrically connected to the constant temperature block 61, the adsorption frame 64 is arranged above the adjusting button 63 and is fixedly connected to the top of the protective cover 62 and covers the middle and upper part of the constant temperature block 61, the parallel plate 65 and the constant temperature block 61 are perpendicular to each other, and the vertical member 66 is embedded in the surface of the parallel plate 65; the constant temperature block 6 1 is consistent with the shape of the protective cover 62, the adjusting button 63 is circular, the width of the adsorption frame 64 is smaller than the width of the protective cover 62, and the parallel plate 65 is solid and carries a plurality of square slots; the protective cover 62 can cover the edge of the thermostatic block 61 according to its own shape, thereby protecting the outer wall of the thermostatic block 61, the adjusting button 63 can achieve the effect of easy rotation according to its own shape, the adsorption frame 64 can be stably installed in the middle and upper part of the thermostatic block 61 according to its own width characteristics, thereby improving the vertical stability of the thermostatic block 61 after the components are inserted, and the parallel plate 65 can evenly arrange the vertical parts 66 according to the square slots it carries.

[0026] See also Figure 3The utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research, comprising: the vertical member 66 is provided with an insert block 661, a bonding layer 662, a limit frame 663, a groove 664, and a jacket 665, the insert block 661 is welded to the lower end of the limit frame 663 through the bonding layer 662, the limit frame 663 and the bonding layer 662 are an integrated structure, the groove 664 is opened inside the limit frame 663, and the jacket 665 is vertically fixed to the inner center of the limit frame 663 through the groove 664; the insert block 661 is welded to the lower end of the limit frame 663 through the bonding layer 662, the limit frame 663 and the bonding layer 662 are an integrated structure, the groove 664 is opened inside the limit frame 663, and the jacket 665 is vertically fixed to the inner center of the limit frame 663 through the groove 664; There are three blocks 661 at the lower end of the limit frame 663. The bonding layer 662 is in a polished shape, and there is a distance between the inner wall of the groove 664 and the jacket 665. The three blocks 661 at the lower end of the limit frame 663 can effectively improve the fixation of the limit frame 663 on the surface of the component. The bonding layer 662 can achieve a stable overlapping effect with the surface of the component based on the polishing characteristics. The inside of the groove 664 can allow the container carrying the liquid phase to be inserted through the distance with the jacket 665, so that the jacket 665 has a distance to expand.

[0027] See also Figure 4 The utility model provides a liquid chromatography-mass spectrometry instrument mechanism for bioequivalence research, including: the jacket 665 is provided with a metal block a1, an identification ring a2, a labeling layer a3, and a rubber body a4, the metal block a1 and the identification ring a2 are perpendicular to each other, the labeling layer a3 and the surface layer of the identification ring a2 are an integrated structure, the rubber body a4 penetrates the center point area of ​​the identification ring a2 and coincides with the center of the metal block a1; the center of the metal block a1 contains a circular vertical groove, the diameter of the identification ring a2 is greater than the diameter of the rubber body a4 and has flexibility; the circular vertical groove in the center of the metal block a1 allows the rubber body a4 to be vertically embedded and then overlapped, and the identification ring a2 can achieve the effect of easy identification and distinction due to the large diameter effect.

[0028] The working principle of the utility model is described as follows:

[0029] First: the liquid chromatography-mass spectrometry mechanism can determine the position of the host 2 through the positioning frame 1, so that after the host 2 is connected to the external power supply, the detection element 3 can be controlled by the program, and then after the relevant liquid phase enters the push plate 5, the push plate 5 can enter the inside of the detection element 3 through the translation effect, so that the detection element 3 can detect the liquid phase substance on the push plate 5 according to the program, and finally the liquid phase after the detection can be poured into the relevant container again, and finally the relevant container can be vertically placed in the constant temperature placement device 6 for temporary storage, so as to avoid the reduction of detection efficiency caused by the operator frequently running to place the relevant liquid phase in a specific storage area;

[0030] Second: The thermostatic block 61 of the thermostatic placement device 6 can protect its own edge through the edge protection cover 62 to avoid damage caused by collision with the outside world. Then, the lower end of the thermostatic block 61 can be electrically connected to the upper end of the host 2, so that after the thermostatic block 61 is activated, it can set its own temperature through the adjustment button 63. For this purpose, the overall temperature of the parallel plate 65 can be changed, so that the temperature of the vertical member 66 on the parallel plate 65 will increase or decrease accordingly, thereby achieving a constant temperature effect for the container in the vertical member 66 and the vertical member 66 can distinguish different types of liquid phases according to its own spacing in the parallel plate 65 to avoid crowding and difficulty in insertion or removal. At the same time, the thermostatic block 61 can penetrate from the bottom of the positioning frame 1, so that the parallel plate 65 and the vertical member 66 can form a communication effect with the detection member 3, which is convenient for the operator to use, and then the adsorption frame 64 in the upper middle part of the thermostatic block 61 can be adsorbed inside the positioning frame 1, ensuring the flattening stability of the parallel plate 65 and the verticality of the vertical member 66;

[0031] Third: the limit frame 663 of the vertical member 66 can be fixed to the surface of the parallel plate 65 through the plug block 661 of the bonding layer 662, so that the groove 664 inside the limit frame 663 and the jacket 665 can be expanded from both sides after the container carrying the liquid phase is inserted through the existing gap. For this reason, the groove 664 can provide an expanded space area for the jacket 665, avoiding the phenomenon that the container carrying the liquid phase cannot be inserted and positioned after the limit frame 663 completely restricts it;

[0032] Fourth: the metal block a1 of the jacket 665 can overlap with the inner bottom of the limit frame 663, and then the identification circle a2 on the upper end of the metal block a1 can clearly mark the liquid phase type in the rubber body a4 through the bonding layer a3, so that it can be easily identified and distinguished. Finally, the rubber body a4 can penetrate into the metal block a1 from the center point of the identification circle a2, so that the temperature of the metal block a1 is affected by the temperature of the parallel plate 65, and the temperature of the rubber body a4 can be changed in all directions. For this reason, it can ensure that the temperature of the edge area of ​​the liquid phase container can remain consistent, avoid the situation where the temperature difference in the detail area is too large, and further ensure the stability of the current liquid state.

[0033] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0034] Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive, and the scope of the utility model is limited by the appended claims rather than the above description, so it is intended to include all changes within the meaning and scope of the equivalent elements of the claims in the utility model. Any reference numerals in the claims should not be regarded as limiting the claims involved.

Claims

1. A liquid chromatography-mass spectrometry instrument for bioequivalence study, comprising: A positioning frame (1), a main unit (2), a detection element (3), a heat dissipation end (4), a push plate (5), and a constant temperature placement device (6), characterized in that: the bottom layer inside the positioning frame (1) and the main unit (2) are perpendicular to each other, the power line of the main unit (2) is buried inside the positioning frame (1) and is electrically connected to the upper detection element (3), the heat dissipation end (4) and the top of the detection element (3) are an integrated structure, the push plate (5) is embedded in the middle and lower area of ​​the surface of the detection element (3), the constant temperature placement device (6) is installed on the left side of the positioning frame (1) and is spaced in coordination with the detection element (3), and the lower end of the constant temperature placement device (6) is electrically connected to the main unit (2).

2. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 1, characterized in that: The constant temperature placement device (6) is provided with a constant temperature block (61), a protective cover (62), an adjustment button (63), an adsorption frame (64), a parallel plate (65), and a vertical piece (66). The edge of the constant temperature block (61) carries the protective cover (62). The adjustment button (63) passes through the side of the protective cover (62) and is electrically connected to the constant temperature block (61). The adsorption frame (64) is arranged above the adjustment button (63) and is fixedly connected to the top of the protective cover (62) and covers the middle and upper part of the constant temperature block (61). The parallel plate (65) and the constant temperature block (61) are perpendicular to each other. The vertical piece (66) is embedded in the surface of the parallel plate (65).

3. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 2, characterized in that: The vertical member (66) is provided with an insert block (661), a bonding layer (662), a limit frame (663), a groove (664), and a jacket (665); the insert block (661) is welded to the lower end of the limit frame (663) through the bonding layer (662); the limit frame (663) and the bonding layer (662) are an integrated structure; the groove (664) is provided inside the limit frame (663); and the jacket (665) is vertically fixed to the inner center of the limit frame (663) through the groove (664).

4. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 3, characterized in that: The jacket (665) is provided with a metal block (a1), an identification ring (a2), a labeling layer (a3), and a rubber body (a4); the metal block (a1) and the identification ring (a2) are perpendicular to each other; the labeling layer (a3) ​​and the surface of the identification ring (a2) are an integrated structure; and the rubber body (a4) penetrates the center point area of ​​the identification ring (a2) and coincides with the center of the metal block (a1).

5. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 2, characterized in that: The thermostatic block (61) and the protective cover (62) are of the same shape, the regulating button (63) is circular in shape, the adsorption frame (64) is smaller in width than the protective cover (62), and the parallel plate (65) is solid and has a plurality of square slots.

6. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 3, characterized in that: The insert blocks (661) are provided with three in total at the lower end of the limiting frame (663); the bonding layer (662) is in a polished and flat form; and there is a distance between the inner wall of the groove (664) and the jacket (665).

7. The liquid chromatography-mass spectrometry apparatus for bioequivalence study according to claim 4, characterized in that: The center of the metal block (a1) contains a circular vertical groove, and the diameter of the identification ring (a2) is larger than the diameter of the rubber body (a4) and is flexible.

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