Micro-fluidic chip clamping equipment

Abstract

The utility model discloses micro-fluidic chip clamping equipment. The micro-fluidic chip clamping equipment comprises a fixed bottom plate, a positioning assembly and a clamping assembly, wherein the positioning assembly and the clamping assembly are arranged on the fixed bottom plate; the positioning assembly comprises an L-shaped clamping plate, a fixing hole and a sliding block installed below the L-shaped clamping plate. The multiple L-shaped clamping plates are symmetrically arranged on the fixed bottom plate, and convex sliding grooves are symmetrically formed in the fixed bottom plate. The micro-fluidic chip comprises a hard micro-fluidic chip and a soft micro-fluidic chip, the hard micro-fluidic chip is in contact with the fixed bottom plate, and the soft micro-fluidic chip is placed above the hard micro-fluidic chip; a cover plate is arranged above the fixed bottom plate in a matched mode, a plurality of through holes are formed in the positions, corresponding to a liquid inlet and a liquid outlet of the soft micro-fluidic chip, of the cover plate, liquid inlet and outlet connectors are installed on the through holes, the L-shaped clamping plates and the convex sliding groove structures are adopted, positioning is conducted through fixing screws, accurate positioning of the micro-fluidic chip is achieved, and the positioning accuracy of the micro-fluidic chip is improved. And the accurate position of the chip in the clamping process is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidic chip clamping, in particular to a microfluidic chip clamping device. Background Art

[0002] Microfluidic chip technology is a technology that controls fluid behavior at a microscale. It is usually composed of a microchannel network and can be used to control the flow of tiny droplets, particles or organisms in microchannels. Compared with macro-scale experimental devices, this technology significantly reduces sample consumption and improves reaction efficiency. It also reduces the pollution of the environment caused by waste generated by the experiment. The parallel advantages of integrated microfluidic chip operation can achieve high-throughput and automated control of experiments, and can be precisely controlled through micro structures such as microvalves and micropumps. This makes microfluidic chips have irreplaceable advantages in the field of analysis. This technology has a wide range of applications in biomedical research, drug screening, environmental monitoring, and chemical analysis. Soft microfluidic chips represented by PDMS materials have become a polymer material widely used in the field of microfluidics because of their low cost, simple use, and good chemical inertness.

[0003] An important part of the function of microfluidic chips in the prior art is to inject macroscopic fluid into microscopic chip pipelines. During this process, the microfluidic chip is usually placed in a groove. Different clamping devices are required for microfluidic chips of different sizes, and the scope of use is not large. At the same time, the chip may be displaced due to improper operation during the clamping process, resulting in inaccurate microchannel docking, affecting the accuracy of fluid operation and experimental results.

[0004] Therefore, it is necessary to improve the microfluidic chip clamping device in the prior art to solve the above problems. Summary of the invention

[0005] The utility model overcomes the shortcomings of the prior art and provides a microfluidic chip clamping device.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a microfluidic chip clamping device, comprising: a fixed base plate, a positioning component arranged on the fixed base plate, and a clamping component installed in cooperation with the positioning component;

[0007] The positioning assembly comprises: a plurality of L-shaped clamping plates, a fixing hole arrayed on each of the L-shaped clamping plates, and a slider installed under the L-shaped clamping plates; the plurality of L-shaped clamping plates are symmetrically arranged on the fixed bottom plate, and the fixed bottom plate is symmetrically provided with convex sliding grooves;

[0008] The microfluidic chip includes a hard microfluidic chip and a soft microfluidic chip, the hard microfluidic chip contacts the fixed base plate, and the soft microfluidic chip is placed above the hard microfluidic chip; a cover plate is arranged above the fixed base plate, and a plurality of through holes are provided on the cover plate corresponding to the liquid inlet and outlet positions of the soft microfluidic chip, and liquid inlet and outlet interfaces are installed on the plurality of through holes.

[0009] In a preferred embodiment of the utility model, the fixed bottom plate is provided with a groove, the positioning assembly is installed in the groove, and the cover plate is provided with an observation window.

[0010] In a preferred embodiment of the utility model, a plurality of movable grooves are symmetrically opened on both side walls of the convex slide groove, a small slide rail is arranged in each movable groove, and the slide block is arranged in a cross shape, and both ends of the slide block are cooperated and installed on the small slide rails.

[0011] In a preferred embodiment of the present invention, a chip placement slot is provided at the angle of each L-shaped clamping plate.

[0012] In a preferred embodiment of the utility model, a plurality of circular holes are arranged in an array in the groove, and the circular holes are arranged corresponding to the fixing holes, and a connecting hole is arranged in an array in the convex slide groove, and the connecting hole is arranged in coordination with the fixing holes.

[0013] In a preferred embodiment of the utility model, fixing screws are arranged on the circular hole, the fixing hole and the connecting hole, and a magnetic suction head is arranged on the surface of the head of the fixing screw.

[0014] In a preferred embodiment of the present invention, the material of the hard microfluidic chip is glass, and the material of the soft microfluidic chip is PDMS.

[0015] In a preferred embodiment of the present invention, threaded holes are arranged in array on the edges of the cover plate and the fixed bottom plate, and the cover plate and the fixed bottom plate are fastened by screws.

[0016] In a preferred embodiment of the utility model, an internal thread is arranged in the through hole, and the liquid inlet and outlet interface is a PEEK connector, and an external thread is arranged on the outer surface of the PEEK connector, which is matched with the internal thread.

[0017] The utility model solves the defects existing in the background technology, and has the following beneficial effects:

[0018] The utility model proposes a microfluidic chip clamping device, which realizes the precise positioning of the microfluidic chip by adopting an L-shaped clamping plate and a convex slide groove structure and using fixing screws for positioning, thereby ensuring the accurate position of the chip during the clamping process, and solving the problem of inaccurate microchannel docking caused by position displacement of the chip due to improper operation during the clamping process, and also ensuring the accuracy of fluid operation and experimental results to a certain extent.

[0019] The utility model adopts a slider and a slider design, and the clamping force is adjustable. The clamping force can be adjusted according to the experimental requirements to ensure that the chip is clamped firmly and evenly. At the same time, an observation window is provided to facilitate the user to observe and adjust the clamping process in real time, and a through hole is provided for installing the inlet and outlet liquid interface, which provides convenience for experimental operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The utility model is further described below in conjunction with the accompanying drawings and embodiments;

[0021] Figure 1 It is a three-dimensional structural diagram of a preferred embodiment of the utility model;

[0022] Figure 2 It is an internal decomposition structure diagram of a preferred embodiment of the utility model;

[0023] Figure 3 It is a top view of the fixed bottom plate of the preferred embodiment of the utility model;

[0024] Figure 4 It is a partial enlarged view of a preferred embodiment of the utility model;

[0025] Figure 5 It is an internal decomposition structure diagram of a preferred embodiment of the utility model;

[0026] In the figure: 1. Fixed base plate; 2. Cover plate; 3. Screws; 4. Inlet and outlet liquid interfaces; 5. Hard microfluidic chip; 6. Soft microfluidic chip; 7. Through hole; 8. Threaded hole; 9. Round hole; 10. L-shaped clamping plate; 11. Connecting hole; 12. Fixed hole; 13. Convex slide groove; 14. Chip placement groove; 15. Slider; 16. Small slide rail; 17. White base plate. DETAILED DESCRIPTION

[0027] The present invention will now be further described in detail in conjunction with the accompanying drawings and embodiments. These drawings are simplified schematic diagrams that only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0028] like Figure 1 and Figure 2As shown, a microfluidic chip clamping device includes: a fixed base plate 1, a positioning component arranged on the fixed base plate 1, and a clamping component installed in cooperation with the positioning component; the positioning component includes: a plurality of L-shaped clamping plates 10, an array of fixing holes 12 arranged on each L-shaped clamping plate 10, and a slider 15 installed under the L-shaped clamping plate 10; the plurality of L-shaped clamping plates 10 are symmetrically arranged on the fixed base plate 1, and convex sliding grooves 13 are symmetrically arranged on the fixed base plate 1.

[0029] The microfluidic chip includes a hard microfluidic chip 5 and a soft microfluidic chip 6. The hard microfluidic chip 5 contacts the fixed base plate 1, and the soft microfluidic chip 6 is placed above the hard microfluidic chip 5; a cover plate 2 is arranged above the fixed base plate 1, and a plurality of through holes 7 are provided on the cover plate 2 corresponding to the liquid inlet and outlet positions of the soft microfluidic chip 6, and liquid inlet and outlet interfaces 4 are installed on the plurality of through holes 7, providing convenience for experimental operation; the fixed base plate 1 is provided with a groove, and the positioning assembly is installed in the groove, and an observation window is provided on the cover plate 2, which is equipped with an observation window to facilitate users to observe and adjust the clamping process in real time.

[0030] like Figure 3 and Figure 4 As shown, a number of movable grooves are symmetrically provided on the two side walls of the convex slide groove 13, each movable groove is provided with a small slide rail 16, and the slider 15 is arranged in a cross shape, and both ends of the slider 15 are fitted and mounted on the small slide rail 16; by adopting the L-shaped clamping plate 10 and the convex slide groove 13 structure, and using the fixing screw 3 for positioning, the microfluidic chip is accurately positioned to ensure the accurate position of the chip during the clamping process.

[0031] A chip placement groove 14 is provided at the angle of each L-shaped clamping plate 10; a plurality of circular holes 9 are arranged in an array in the groove, and the circular holes 9 are arranged correspondingly with the fixing holes 12, and a connection hole 11 is arranged in an array in the convex slide groove 13, and the connection hole 11 is arranged in coordination with the fixing hole 12; fixing screws are provided on the circular holes 9, the fixing holes 12 and the connecting holes 11, and a magnetic suction head is provided on the surface of the head of the fixing screw; it should be noted that a notch is provided on the fixing hole 12, and the head of the fixing screw is placed in the notch accordingly, which does not affect the fit and fastening of the cover plate 2 and the fixed bottom plate 1, such as Figure 5 shown.

[0032] The material of the hard microfluidic chip 5 is glass, and the material of the soft microfluidic chip 6 is PDMS; threaded holes 8 are arranged in an array on the edges of the cover plate 2 and the fixed base plate 1, and the cover plate 2 and the fixed base plate 1 are fastened by screws 3; an internal thread is arranged in the through hole 7, and the inlet and outlet liquid interface 4 is a PEEK connector, and the outer surface of the PEEK connector is provided with an external thread, which is matched with the internal thread; by adopting the slider 15 and the slider 15 design, the clamping force is adjustable, and the clamping force is adjusted according to the experimental requirements to ensure that the chip is clamped firmly and evenly.

[0033] It should be noted that since the bottom is provided with a round hole 9 and a connecting hole 11 , which will affect visual observation, a white base film is placed under the hard microfluidic chip 5 to reduce the number of fixing holes 12 .

[0034] When the utility model is used, the required hard microfluidic chip 5 and soft microfluidic chip 6 are prepared, and it is ensured that the clamping equipment is in a clean state, the fixed base plate 1 is placed on a flat workbench, and the hard microfluidic chip 5 is placed on the fixed base plate 1, and the chip is in close contact with the base plate to ensure that the position of the hard microfluidic chip 5 is accurate and without offset; the soft microfluidic chip 6 is placed above the hard microfluidic chip 5 to ensure that the soft chip is aligned with the hard chip, and then the hard microfluidic chip 5 and the soft microfluidic chip 6 are clamped by adjusting the L-shaped clamping plate 10, and positioned by the fixing screw 3. If it is to be taken out, the head of the fixing screw 3 is sucked out by the magnetic buckle for easy operation; after the microfluidic chip is fixed, the cover plate 2 is placed above the soft microfluidic chip 6, and it is ensured that the liquid inlet and outlet of the soft microfluidic chip 6 correspond to the through hole 7 on the cover plate 2, and the fixed base plate 1 and the cover plate 2 are fixed by the screws 3. At this time, the microfluidic chip is clamped and subsequent experiments can be carried out.

[0035] The above is based on the ideal embodiment of the utility model. Through the above description, relevant personnel can make various changes and modifications without deviating from the technical concept of the utility model. The technical scope of this utility model is not limited to the content in the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A microfluidic chip clamping device, comprising: A fixed base plate (1), a positioning component arranged on the fixed base plate (1), and a clamping component mounted in cooperation with the positioning component, characterized in that: The positioning assembly comprises: a plurality of L-shaped clamping plates (10), a fixing hole (12) arranged in an array on each of the L-shaped clamping plates (10), and a sliding block (15) installed below the L-shaped clamping plates (10); the plurality of L-shaped clamping plates (10) are symmetrically arranged on the fixed base plate (1), and the fixed base plate (1) is symmetrically provided with convex sliding grooves (13); The microfluidic chip comprises a hard microfluidic chip (5) and a soft microfluidic chip (6), wherein the hard microfluidic chip (5) contacts the fixed base plate (1), and the soft microfluidic chip (6) is placed above the hard microfluidic chip (5); a cover plate (2) is arranged above the fixed base plate (1), and a plurality of through holes (7) are provided on the cover plate (2) at positions corresponding to liquid inlets and outlets of the soft microfluidic chip (6), and liquid inlet and outlet interfaces (4) are installed on the plurality of through holes (7).

2. A microfluidic chip clamping device according to claim 1, characterized in that: The fixed base plate (1) is provided with a groove, the positioning assembly is mounted in the groove, and the cover plate (2) is provided with an observation window.

3. The microfluidic chip clamping device according to claim 1, characterized in that: A plurality of movable grooves are symmetrically provided on the two side walls of the convex slide groove (13), each of the movable grooves is provided with a small slide rail (16), and the slide block (15) is arranged in a cross shape, with both ends of the slide block (15) being fitted and mounted on the small slide rail (16).

4. The microfluidic chip clamping device according to claim 1, characterized in that: A chip placement slot (14) is provided at the included angle of each L-shaped clamping plate (10).

5. The microfluidic chip clamping device according to claim 2, characterized in that: A plurality of circular holes (9) are arranged in an array in the groove, and the circular holes (9) are arranged corresponding to the fixing holes (12); and a connection hole (11) is arranged in an array in the convex slide groove (13), and the connection hole (11) is arranged in coordination with the fixing holes (12).

6. The microfluidic chip clamping device according to claim 5, characterized in that: The circular hole (9), the fixing hole (12) and the connecting hole (11) are provided with fixing screws, and the surface of the head of the fixing screw is provided with a magnetic suction head.

7. The microfluidic chip clamping device according to claim 1, characterized in that: The material of the hard microfluidic chip (5) is glass, and the material of the soft microfluidic chip (6) is PDMS.

8. The microfluidic chip clamping device according to claim 1, characterized in that: Threaded holes (8) are arranged in an array on the edges of the cover plate (2) and the fixed base plate (1), and the cover plate (2) and the fixed base plate (1) are fastened by screws (3).

9. The microfluidic chip clamping device according to claim 1, characterized in that: The through hole (7) is provided with an internal thread, and the liquid inlet and outlet interface (4) is a PEEK connector, and the outer surface of the PEEK connector is provided with an external thread, which is arranged in coordination with the internal thread.

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