Pathological tissue dehydration and embedding integrated processor

Abstract

A pathological tissue dehydration and embedding integrated processor comprises an embedding bottom die, an embedding frame and a gland, and an embedding groove is formed in the embedding bottom die and suitable for containing pathological tissue; the embedding frame covers the embedding groove; the gland is located on the side, away from the embedding bottom die, of the embedding frame and provided with a tissue fixing structure. A first avoiding hole is formed in the embedding frame, so that the tissue fixing structure extends into the embedding groove to fix the pathological tissue. The pathological tissue in the embedding groove is fixed by arranging the tissue fixing structure, so that the risk of deformation and displacement of the pathological tissue after dehydration can be reduced, the steps are simplified, one-time coherent operation of dehydration and embedding is facilitated, and the time is saved. Meanwhile, the gland is used as an independent component, when the wax liquid in the embedding groove is about to be solidified, an operator can directly take down the gland, only pathological tissues exist in the embedding groove after the wax liquid in the embedding groove is completely solidified, the embedding effect is good, the quality of tissue wax blocks is better, and subsequent slicing and dyeing operation can be promoted.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to an integrated processor for dehydration and embedding of pathological tissues. Background Art

[0002] Biological tissue dehydration and embedding devices are widely used in medical systems, medical schools and related scientific research units, animal and plant research institutes, and food testing units. In the prior art, biological tissue dehydration, wax dipping, and embedding are completed by two devices, a dehydrator and an embedding machine, respectively. Among them, there is no fully automated equipment for embedding, and operators usually operate manually on the embedding machine with tweezers, which has cumbersome steps and low efficiency. Moreover, during the dehydration process, the tissue will shrink and deform, and it needs to be transferred in the middle. Small tissues also need to be wrapped with gauze, and manual operation is prone to errors.

[0003] In this regard, domestic and foreign scholars have come up with a variety of ways to solve the problems of dehydration and manual embedding. In order to achieve integrated dehydration and embedding, the main technical solutions are divided into two categories:

[0004] The first type: directly use the bottom of the embedding box frame to press the tissue cover into the embedding mold. The main problem of this solution is that the tissue is not fixed, so that the tissue deforms and shifts during the dehydration process, so that a qualified wax block cannot be formed. Alternatively, in order to press the tissue, the depth of the embedding mold groove is made shallow, and then the embedding box frame is used to directly press the tissue. This wax block is easy to touch the bottom frame of the embedding box after a few slices, affecting the sectioning.

[0005] The second type: the tissue is pressed with a silicone sponge, and the silicone sponge is not taken out and wrapped together with the tissue to form a wax block. Another foreign patent uses a deformable elastic foot with a silicone hook or a flexible rod-shaped silicone beard at the bottom of the embedding frame to press the tissue and not take it out and embed it together with the tissue to form a wax block. However, the above two silicone structures are wrapped together with the tissue in the wax block, which will affect the subsequent sectioning and staining operations. When sectioning, the tissue will wrinkle, cells will fall off, silicone residues will fall off, and the blade will be easily damaged, which will directly affect the staining and preparation effect and have poor practicality.

[0006] The integrated dehydration and embedding process is a recognized technical difficulty in the field of pathology. At present, there is no good technical solution at home and abroad to solve the problem of dehydration and embedding and physical and chemical treatment, especially the treatment plan for special types of tissues. The tissue can be pressed during the dehydration and wax immersion stage, and the structure that presses the tissue can be removed when the wax block is finally formed. This is an ideal state. Although it seems simple to achieve this effect, it is indeed a technical difficulty that has plagued pathology technicians for many years and is the goal pursued by R&D personnel. Utility Model Content

[0007] The purpose of this application is to provide an integrated processor for dehydration and embedding of pathological tissues, which can not only fix the pathological tissues, but also will not introduce other structures or media into the formed tissue wax blocks. It has a good embedding effect and is conducive to subsequent slicing and staining operations. It is a structural method to achieve the above ideal state.

[0008] The technical solutions provided by this application are as follows:

[0009] A pathological tissue dehydration and embedding integrated processor, comprising:

[0010] An embedding bottom mold, wherein the embedding bottom mold is provided with at least one embedding groove, and the embedding groove is suitable for accommodating pathological tissue;

[0011] An embedding frame, covering the embedding groove;

[0012] The pressure cover is located on a side of the embedding frame away from the embedding bottom mold, and the pressure cover is provided with a tissue fixing structure.

[0013] The embedding frame is provided with a first avoidance hole corresponding to the tissue fixing structure, so that the tissue fixing structure can extend into the embedding groove to fix the pathological tissue;

[0014] When the wax liquid at the bottom layer and around the pathological tissue in the embedding groove is initially solidified, the pressure cover moves away from the embedding bottom mold, and the tissue fixing structure withdraws from the embedding groove.

[0015] In some embodiments, a plurality of rods are provided on one side of the gland facing the embedding frame to form the tissue fixing structure;

[0016] or

[0017] A pressing block is provided on one side of the pressing cover facing the embedding frame to form the tissue fixing structure.

[0018] In some embodiments, the rod member includes a limiting rod and a fixing rod, the fixing rod is arranged around the limiting rod, and the length of the fixing rod is greater than the length of the limiting rod;

[0019] Wherein, the limiting rod on the gland is suitable for avoiding the pathological area in the pathological tissue, and the fixing rod is suitable for pressing the normal area in the pathological tissue;

[0020] or

[0021] A weight-reducing groove is provided on one side of the pressure cover away from the embedding frame at a position corresponding to the pressure block, and a weight-reducing hole is provided on the side wall of the pressure block and connected to the weight-reducing groove;

[0022] The end face of the pressing block and the area of ​​the pressing block side wall close to the end face of the pressing block are both provided with flow holes connected to the weight reduction groove, and the end face of the pressing block is rectangular or circular; and / or, the end face of the pressing block is provided with a plurality of protrusions, which are suitable for pressing against the pathological tissue and forming a gap between the pressing block and the pathological tissue for fluid flow.

[0023] In some embodiments, a plurality of partitioning protrusions are provided at the bottom of the embedding groove, and the plurality of partitioning protrusions are arranged in sequence to divide the embedding groove into at least two placement areas;

[0024] The placement area is circular, rectangular or strip-shaped;

[0025] and / or

[0026] The bottom of the embedding groove is provided with a plurality of supporting protrusions for carrying the pathological tissue.

[0027] In some embodiments, the edge of the gland is provided with a mounting ear, the mounting ear is provided with a fixing hole, a locking member is passed through the fixing hole, and the locking member includes a screw and a nut; the screw is passed through the fixing hole, and a magnetic attraction portion is provided at one end of the screw facing the embedded bottom mold, and the nut is screwed on one end of the screw away from the magnetic attraction portion; and a spring is provided on the outer sleeve of the screw, and the spring is located between the mounting ear and the nut;

[0028] A mounting hole is provided on a side of the embedded bottom mold away from the gland, a magnet is provided in the mounting hole, and a limiting hole is provided on a side of the embedded bottom mold facing the gland, the limiting hole and the mounting hole are arranged in a one-to-one correspondence;

[0029] The magnet is used to absorb the magnetic attraction part into the limiting hole. When the magnetic attraction part is magnetically connected to the magnet, one end of the spring is pressed against the mounting ear, and the other end of the spring is pressed against the nut, so that the gland is elastically and movably connected to the embedded bottom mold, and the nut is suitable for adjusting the compression degree of the spring; and

[0030] The edge of the pressure cover is also provided with a lifting ear, which is suitable for the lifting plate to drive the pressure cover to move in a direction away from the embedding bottom mold, thereby driving the tissue fixing structure to evacuate the embedding groove.

[0031] In some embodiments, the embedding frame includes a main plate and a side plate;

[0032] The main board is in a rectangular structure, and the number of the side panels is four, which are respectively arranged on the four edges of the main board; and the four side panels are sequentially a first side panel, a second side panel, a third side panel and a fourth side panel, and the first side panel has a first inclined surface on a side away from the third side panel;

[0033] The main board is suitable for covering the embedding groove, and the main board is provided with the first avoidance hole.

[0034] In some embodiments, the embedding bottom mold is provided with at least one set of buckle sets for fixing the embedding frame;

[0035] Each of the buckle groups includes a first buckle and a second buckle that are arranged opposite to each other, the first buckle has a second inclined surface on a side facing the second buckle, and the second inclined surface is arranged parallel to the first inclined surface, and the first buckle is suitable for abutting against the first side plate of the embedding frame; and, the second buckle is inclinedly arranged at one end away from the embedding bottom mold toward the first buckle, and is suitable for abutting against the third side plate of the embedding frame;

[0036] A handle is provided on the third side plate of the embedding frame, which is away from the first side plate and the end of the embedding bottom mold.

[0037] In some embodiments, the pathological tissue dehydration and embedding integrated processor further comprises:

[0038] Baffles;

[0039] The embedding groove bottom is provided with a plurality of flow holes; and / or, the embedding bottom mold is provided with a plurality of flow holes around the embedding groove; and / or, the embedding frame is provided with a plurality of flow holes at a portion suitable for covering the embedding groove; and / or, the pressure cover is provided with a plurality of flow holes; and the flow holes are in a circular or strip-shaped hole structure;

[0040] The baffle plate is located at a side of the embedding bottom mold away from the embedding frame, and is suitable for blocking the liquid flow hole on the embedding bottom mold.

[0041] In some embodiments, the pathological tissue dehydration and embedding integrated processor further comprises:

[0042] A lifting plate is arranged between the pressure cover and the embedding bottom mold, and the lifting plate is provided with a second avoidance hole for avoiding the embedding frame;

[0043] When the lifting plate moves in a direction away from the embedding bottom mold, the lifting plate drives the pressure cover to move in a direction away from the embedding bottom mold, thereby driving the tissue fixing structure to evacuate the embedding groove;

[0044] and / or

[0045] Refrigeration plate and heat conducting plate;

[0046] The refrigeration plate is used to solidify the wax liquid in the embedding tank, and the heat conduction plate is used to heat the gland.

[0047] The technical effects of this application are:

[0048] 1. In the present application, by setting a gland, the tissue fixing structure on the gland can be used to fix the pathological tissue in the embedding tank, thereby reducing the risk of deformation and displacement of the pathological tissue after dehydration, which is conducive to the one-time continuous operation of dehydration and embedding, and there is no need to transfer the pathological tissue in the middle, which is simple and convenient to operate. At the same time, as a component that can exist independently, when the wax liquid in the embedding tank is about to solidify, the operator can directly remove the gland, so that the tissue fixing structure on the gland can be evacuated from the embedding tank. In this way, after the wax liquid in the embedding tank is completely solidified, only pathological tissue exists in it, the embedding effect is good and the quality of the tissue wax block is better, which is conducive to the advancement of subsequent slicing and staining operations, and has strong practicality.

[0049] 2. The pathological tissue dehydration and embedding integrated processor provided in the present application can also be used as the main component of the fully automatic dehydration and embedding integrated machine, eliminating the entire manual embedding step, so that the fully automatic dehydration and embedding integrated machine can operate autonomously at night, and the operator can perform slicing and staining work as soon as he goes to work in the morning, thereby advancing the work of the pathology department by more than 2 hours a day, and the patient can also get the pathology report in advance.

[0050] 3. In the present application, the gland and the embedding bottom mold are connected by magnetic attraction, which makes disassembly and assembly more convenient. The operator can quickly position the locking piece into the mounting hole provided with a magnet to complete the alignment and fixation of the gland and the embedding bottom mold; and can quickly remove the gland from the embedding bottom mold when the wax liquid in the embedding tank is about to solidify, so as to avoid the situation that the tissue fixing structure cannot be separated from the embedding tank. In addition, the present application also introduces a spring. When the gland and the embedding bottom mold are connected by magnetic attraction, one end of the spring is pressed against the mounting ear and the other end is pressed against the nut. At this time, the spring can play a good buffering role, realizing the elastic pressing of the tissue fixing structure on the gland against the pathological tissue. Moreover, by utilizing the elastic force of the spring, the tissue fixing structure can still be pressed against the pathological tissue after the pathological tissue is dehydrated and shrunk, realizing the limited fixation of the pathological tissue, and can better adapt to pathological tissues of different thicknesses.

[0051] 4. In the present application, a plurality of partitioning protrusions are provided at the bottom of the embedding tank, and the plurality of partitioning protrusions are arranged in sequence to divide the embedding tank into at least two placement areas, and the placement areas may be circular, rectangular or strip-shaped, so that operators can perform dehydration and embedding treatments on special types of tissues, such as multiple small tissues, broken tissues, tubular tissues, ESD (ESD, endoscopic submucosal dissecfion) strip tissues, etc., to further improve the versatility of the integrated processor for dehydration and embedding of pathological tissues provided by the present application, and fill the gap in the prior art in equipment for dehydration and embedding treatments on special types of tissues.

[0052] 5. In the present application, a plurality of supporting protrusions are provided at the bottom of the embedding groove, which can be used to carry the pathological tissue, so that the pathological tissue as a whole can be completely immersed in different reagents (fixative, dehydrating liquid, transparent liquid or wax liquid), with better treatment effect, which is conducive to the subsequent pathological analysis of slices and has high practical significance. In addition, by providing a plurality of convex points on the end face of the pressing block on the pressure cover, the convex points are pressed against the pathological tissue to fix the pathological tissue, and a gap can be formed between the pathological tissue and the pressing block for the reagent to flow, which is also conducive to the pathological tissue as a whole being completely immersed in different reagents, and the treatment effect is good; at the same time, the provision of a plurality of convex points can also increase the friction between the pressing block and the pathological tissue, reduce the risk of displacement of the pathological tissue, have strong practicality, and are more conducive to the molding of high-quality tissue wax blocks.

[0053] 6. In the present application, a lifting plate is provided between the gland and the embedding bottom mold, and a second avoidance hole for avoiding the embedding frame is provided on the lifting plate, so that when the lifting plate moves in a direction away from the embedding bottom mold, the lifting plate can drive the gland to move together, thereby driving the tissue fixing structure on the gland to evacuate the embedding groove. By providing a lifting plate, the present application can drive multiple glands to move together at the same time, thereby realizing the synchronous processing of multiple different pathological tissues, greatly improving the processing efficiency of pathological tissue dehydration embedding, and has strong practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0054] The present application is further described in detail below with reference to the accompanying drawings and specific implementation methods:

[0055] Figure 1 is a top view of a pathological tissue dehydration and embedding integrated processor provided in one embodiment of the present application;

[0056] Figure 2 yes Figure 1 A cross-sectional view along the AA direction is shown;

[0057] Figure 3 yes Figure 1 A top view of the structure shown with the lifting plate and part of the gland removed;

[0058] Figure 4 yes Figure 3 A local enlarged schematic diagram of point B is shown;

[0059] Figure 5 is a top view of an embedded bottom mold provided in one embodiment of the present application;

[0060] Figure 6 yes Figure 5 A bottom view of the provided embedded base mold;

[0061] Figure 7 yes Figure 5 A side view of the provided embedding base mold;

[0062] Figure 8 yes Figure 5 An overall side view of the provided embedding bottom mold and the embedding frame provided in the present application;

[0063] Fig. 9 is a schematic diagram of the three-dimensional structure of an embedding frame provided in one embodiment of the present application;

[0064] Fig.10 is a schematic diagram of the three-dimensional structure of a gland provided in one embodiment of the present application;

[0065] Fig.11 yes Fig. 9 The embedding frames and Fig.10 A three-dimensional assembly diagram of the provided gland;

[0066] Fig.12 is a schematic diagram of the three-dimensional structure of an embedding frame provided in another embodiment of the present application;

[0067] Fig.13 is a schematic diagram of the three-dimensional structure of a gland provided in another embodiment of the present application;

[0068] Fig.14 is a schematic diagram of the three-dimensional structure of a gland provided in yet another embodiment of the present application;

[0069] Fig.15 is a top view of a pathological tissue dehydration and embedding integrated processor provided in another embodiment of the present application;

[0070] Fig.16 yes Fig.15 A cross-sectional view along the CC direction is shown;

[0071] Fig.17 is a schematic diagram of the three-dimensional structure of an embedding frame provided in yet another embodiment of the present application;

[0072] Fig.18 is a schematic diagram of the three-dimensional structure of an embedding frame provided in yet another embodiment of the present application;

[0073] Fig.19 is a schematic diagram of the three-dimensional structure of a gland provided in yet another embodiment of the present application;

[0074] Fig. 20 is a schematic diagram of the three-dimensional structure of a gland provided in yet another embodiment of the present application;

[0075] Fig.21 is a schematic diagram of a three-dimensional structure of a gland in one state provided in yet another embodiment of the present application;

[0076] Fig. 22 yes Fig.21 A schematic diagram of the three-dimensional structure of the provided gland in another state;

[0077] Fig.23 yes Fig.18 The embedding frames and Fig. 20 A three-dimensional assembly diagram of the provided gland;

[0078] Fig.24 is a top view of an embedded bottom mold provided in another embodiment of the present application;

[0079] Fig.25 is a three-dimensional assembly diagram of an embedding frame and a gland provided in another embodiment of the present application;

[0080] Fig.26 It is a three-dimensional structural schematic diagram of the lifting plate provided in this application;

[0081] Fig. 27 yes Fig.15 An exploded view of the provided pathological tissue dehydration and embedding integrated processor.

[0082] Description of Figure Numbers:

[0083] 100, embedded bottom mold; 110, embedded groove; 111, partitioning protrusion; 112, placement area; 120, limiting hole; 130, first buckle; 131, second inclined surface; 140, second buckle;

[0084] 200, embedding frame; 210, main board; 211, first avoidance hole; 220, first side plate; 221, first inclined surface; 230, second side plate; 240, third side plate; 241, handle; 250, fourth side plate;

[0085] 300, gland; 310, rod; 311, limit rod; 312, fixing rod; 320, pressing block;

[0086] 321, weight reduction hole; 330, weight reduction groove; 340, mounting ear; 341, fixing hole; 350, screw;

[0087] 351, magnetic attraction part; 360, nut; 370, spring; 380, lifting ear;

[0088] 400, magnet;

[0089] 500, baffle;

[0090] 600, lifting plate; 610, second avoidance hole;

[0091] 701. Liquid flow hole. DETAILED DESCRIPTION

[0092] In the following description, specific details such as specific system structures, technologies, etc. are provided for the purpose of illustration rather than limitation, so as to provide a thorough understanding of the embodiments of the present application. However, it should be clear to those skilled in the art that the present application may also be implemented in other embodiments without these specific details. In other cases, detailed descriptions of well-known systems, devices, circuits, and methods are omitted to prevent unnecessary details from obstructing the description of the present application.

[0093] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the specific implementation methods of the present application will be described below with reference to the accompanying drawings. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings and other implementation methods can be obtained based on these drawings without creative work.

[0094] In order to simplify the drawings, only the parts related to the invention are schematically shown in each figure, and they do not represent the actual structure of the product. In addition, in order to simplify the drawings and facilitate understanding, in some figures, only one of the parts with the same structure or function is schematically drawn or marked. In this article, "one" not only means "only one", but also means "more than one".

[0095] It should be further understood that the term “and / or” used in the specification and appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations.

[0096] In this document, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0097] In the embodiments shown in the drawings, the directions (such as up, down, left, right, front and back) used to explain the structure and movement of various devices of the present application are not absolute but relative. These descriptions are appropriate when these devices are in the positions shown in the drawings. If the description of the positions of these devices changes, the directions also change accordingly.

[0098] In addition, in the description of the present application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0099] According to a specific embodiment provided by this application, see Figure 1 , Figure 2 , Fig.15 , Fig.16 and Fig. 27 , a pathological tissue dehydration and embedding integrated processor, specifically, may include an embedding bottom mold 100, an embedding frame 200 and a pressure cover 300. Among them, the embedding bottom mold 100 is provided with at least one embedding groove 110, the embedding groove 110 is suitable for accommodating pathological tissue, and the embedding frame 200 is covered on the embedding groove 110; the pressure cover 300 is located on the side of the embedding frame 200 away from the embedding bottom mold 100, and the pressure cover 300 is provided with a tissue fixing structure. At this time, the embedding frame 200 is provided with a first avoidance hole 211 corresponding to the tissue fixing structure, so that the tissue fixing structure can extend into the embedding groove 110 to fix the pathological tissue.

[0100] Specifically, during use, the operator needs to first place the pathological tissue in the embedding tank 110 on the embedding bottom mold 100, and then buckle the embedding frame 200 on the top of the embedding tank 110. Next, place the pressure cover 300 on the top of the embedding frame 200, and make the tissue fixing structure on the pressure cover 300 extend into the inside of the embedding tank 110 through the first avoidance hole 211 on the embedding frame 200, so as to press the pathological tissue in the embedding tank 110 and fix the pathological tissue. Subsequently, the assembled pathological tissue dehydration and embedding integrated processor is immersed in different reagents (such as fixative, dehydration liquid, transparent liquid, wax liquid, etc.) in steps to dehydrate, transparentize, and dip wax on the pathological tissue in the embedding tank 110. After the wax dipping is completed, the wax liquid is left in the embedding tank 110, and the embedding tank 110 is placed on a cold table or a refrigeration plate to initially solidify the wax liquid around the bottom pathological tissue in the embedding tank 110, and fix the bottom pathological tissue by the solidified wax to prevent it from moving. At the same time, when the wax liquid on the upper layer of the embedding tank 110 has not yet solidified, the gland 300 is heated and removed, so that the tissue fixing structure on the gland 300 is evacuated from the embedding tank 110, so that the risk of deformation and displacement of the pathological tissue can be reduced to the greatest extent, and at the same time, the pathological tissue can be kept flat during the embedding process, and the embedding effect is good. The operator does not need to fill the silicone sponge with the tissue for embedding, and the operation is simple. After the wax liquid is completely solidified, a tissue wax block with only pathological tissue inside can be obtained.

[0101] During the entire operation, the operator does not need to transfer the pathological tissue to the embedding machine for manual embedding after dehydration, but the tissue wax block is prepared after the tissue is dehydrated and waxed, which saves the manual operation of embedding on the embedding machine, and the operation is more convenient and safe, which not only saves manpower and material resources, but also improves production efficiency. Moreover, compared with the wax blocks containing other impurities (such as silica gel) in the prior art, the wax blocks formed after the pathological tissue is dehydrated and displaced, and the wax blocks with small thickness, the tissue wax blocks made in this embodiment are of better quality and more conducive to subsequent sectioning and staining operations.

[0102] If there are other impurities in the wax block, such as the silicone used to fix the pathological tissue in the prior art, it will cause the knife to slip during subsequent slicing, which will affect the quality of the slices and damage the props. Moreover, in the subsequent staining process, the silicone material may also react chemically with the reagent, thereby contaminating the tissue and even causing the wax block to fall off during staining. If the pathological tissue is deformed and displaced after dehydration due to incomplete fixation, the final wax block will be an unqualified wax block that cannot be used and can only be re-embedded for repair; relatively speaking, in order to press the pathological tissue, the depth of the embedding mold groove is made shallow, and then the pathological tissue is directly pressed with the embedding box frame. The wax block formed in this way is thin in thickness, and it is easy to touch the embedding frame 200 after cutting a few slices, which will also affect the quality of the slices.

[0103] Specifically, see Figure 5 and Fig.24 The bottom of the embedding tank 110 is provided with a plurality of flow holes 701 to facilitate the circulation of the reagent. Thus, when the operator immerses the assembled pathological tissue dehydration and embedding integrated processor in the reagent, the pathological tissue in the embedding tank 110 can also be directly immersed in the reagent.

[0104] In addition, in this embodiment, different sizes of flow holes 701 can be set according to the size of the pathological tissue. If the pathological tissue is small, a smaller flow hole 701 can be set to prevent the pathological tissue from being flushed out; if the pathological tissue is large, a larger flow hole 701 can be set to further facilitate the circulation of the reagent.

[0105] Of course, see Figure 5 and Fig.24 In actual production, a plurality of flow holes 701 may be provided around the embedding groove 110 in the embedding bottom mold 100 to further accelerate the flow of the reagent; in addition, see Fig. 9 , Fig.11 , Fig.12 , Fig.17 , Fig.18 and Fig.25 , a plurality of flow holes 701 may be provided at a portion of the embedding frame 200 suitable for covering the embedding tank 110, and, see Fig.10 , Fig.13 , Fig.14 and Figures 19 to 22 A plurality of liquid flow holes 701 are provided on the pressure cover 300, which are not limited here and are all within the protection scope of the present application.

[0106] The smaller-sized flow holes 701 may be configured as small round holes, and the larger-sized flow holes 701 may be configured as rectangular or strip-shaped holes.

[0107] Further, see Figure 2 , Fig.16 and Fig. 27 In order to allow the wax liquid to remain in the embedding tank 110, the pathological tissue dehydration and embedding integrated processor also includes a baffle 500. After the wax dipping is completed, the operator fixes the baffle 500 on the side of the embedding bottom mold 100 away from the embedding frame 200 to block the liquid flow hole 701 on the embedding bottom mold 100.

[0108] In a specific embodiment, see Figure 5 and Fig.24 According to the size of the pathological tissue, embedding grooves 110 of different sizes can be set, so that the pathological tissue dehydration and embedding integrated processor provided in this embodiment can adapt to more types of pathological tissues and expand the scope of application. At this time, different tissue fixing structures need to be set on the gland 300 according to different embedding grooves 110.

[0109] Specifically, this application mainly provides two tissue fixing structures, see Figure 2 , Fig.10 , Fig.11 , Fig.13 , Fig.14 and Fig.25 One method is to set a plurality of rods 310 on the side of the gland 300 facing the embedding frame 200 to form the above-mentioned tissue fixing structure. At this time, the required number of rods 310 can be set according to the size of the embedding groove 110 and the shape, orientation and size of the pathological tissue in the embedding groove 110, and the rods 310 can be arranged in sequence along a specific arrangement.

[0110] See also Fig.16 and Figures 19 to 23 Another method is to set a pressing block 320 on the side of the pressure cover 300 facing the embedding frame 200 to form the above-mentioned tissue fixing structure. In this case, the pressing blocks 320 of different shapes and sizes can be set according to the shape and size of the embedding groove 110, and the shape and size of the pressing blocks 320 are not affected by the shape, orientation, and size of the pathological tissue in the embedding groove 110.

[0111] The above two tissue fixation structures have their own advantages and disadvantages. The rod 310 is used to press the pathological tissue, which is easier to separate from the initially solidified wax block in the later stage, but the fixation effect of the pathological tissue is slightly worse than that of the tissue fixation structure using the pressing block 320; and the pressing block 320 is used to press the pathological tissue, which has a better fixation effect and makes the pathological tissue smoother, but it is slightly more difficult to separate from the initially solidified wax block in the later stage than the tissue fixation structure using the pressing rod. In this regard, medical staff can flexibly select a suitable gland 300 according to actual needs, all of which are within the protection scope of this application.

[0112] Specifically, see Figure 2On the basis of the embodiment of forming the above-mentioned tissue fixing structure by setting a plurality of rods 310, the rods 310 may specifically include a limiting rod 311 and a fixing rod 312, the fixing rod 312 is arranged around the limiting rod 311, and the length of the fixing rod 312 is greater than the length of the limiting rod 311. When the gland 300 is placed above the embedding frame 200, the limiting rod 311 presses the edge of the pathological tissue, thereby fixing the pathological tissue. When fixed, the pathological tissue is generally placed with the front side facing the bottom of the embedding tank 110, with a certain directionality; and the limiting rod 311 can avoid the lesion area in the pathological tissue, and at the same time play a certain limiting role on the pathological tissue.

[0113] In extreme cases, the pathological tissue has a small probability of detaching from the fixing rod 312, especially during the process of dehydration and shrinkage. At this time, the limiting rod 311 can also prevent the pathological tissue from turning over to the other side, which is highly practical.

[0114] Of course, see Fig.10 , Fig.13 and Fig.14 In actual production, the rod 310 may also include only the fixing rod 312, and the lengths of several fixing rods 312 are consistent, which are not described one by one here, and are all within the protection scope of this application.

[0115] Specifically, see Figures 19 to 23 On the basis of the embodiment of forming the above-mentioned tissue fixing structure by setting the pressing block 320, a weight-reducing groove 330 is provided at the position of the pressing block 320 on the side of the pressing cover 300 away from the embedding frame 200, and a weight-reducing hole 321 connected to the weight-reducing groove 330 is provided on the side wall of the pressing block 320, which is conducive to the lightweight production of the pressing cover 300. At the same time, the end face of the pressing block 320 and the area of ​​the side wall of the pressing block 320 close to the end face of the pressing block 320 are both provided with a flow hole 701 connected to the weight-reducing groove 330. Because the end face of the pressing block 320 is the entire pressing of the pathological tissue, the side of the pathological tissue being pressed is difficult to be contacted by the reagent, so the flow hole 701 needs to be provided so that the side of the pathological tissue being pressed can contact the reagent.

[0116] Among them, the size of the liquid flow hole 701 set on the end face of the pressing block 320 and the area of ​​the side wall of the pressing block 320 close to the end face of the pressing block 320 should be smaller than the size of the liquid flow hole 701 on the surface of the pressing cover 300, so that the pressing block 320 can adapt to pathological tissues of different sizes and prevent smaller pathological tissues from escaping from the liquid flow hole 701 on the end face of the pressing block 320.

[0117] Furthermore, the end surface of the pressing block 320 is also provided with a plurality of protrusions (not shown), which are suitable for pressing against the pathological tissue. At this time, the pathological tissue and the pressing block 320 are separated by a distance due to the setting of the protrusions, forming a gap for fluid flow. In conjunction with the flow holes 701 on the pressing block 320, the reagent can flow on the side where the pathological tissue is pressed, which is more conducive to the reagent infiltration into the pathological tissue and improving the quality of the tissue wax block.

[0118] In addition, the setting of the convex points can also increase the friction between the pressing block 320 and the pathological tissue, reduce the risk of pathological tissue displacement, and is highly practical and more conducive to the formation of high-quality tissue wax blocks. Figure 20 to Figure 24 The embedding tank 110 is mostly rectangular in structure, and the shape of the pressing block 320 is adapted to the embedding tank 110 and is also mostly rectangular in structure. Fig.19 and Fig.24 The embedding groove 110 can be set to a circular structure, and the shape contour of the pressing block 320 is adapted to the embedding groove 110 and also has a circular structure, which can improve the sealing between the pressing block 320 and the edge of the embedding groove 110 and prevent small-sized pathological tissue from falling out.

[0119] In a specific embodiment, see Fig.24 The bottom of the embedding tank 110 is provided with a plurality of partitioning protrusions 111, which are arranged in sequence to divide the embedding tank 110 into at least two placement areas 112, each of which can be used to place pathological tissues, so as to perform dehydration embedding treatment on multiple pieces of pathological tissues.

[0120] Among them, the placement area 112 formed by the partitioning protrusion 111 can be circular, rectangular or strip-shaped, so that the operator can better perform dehydration and embedding treatments on various special types of pathological tissues, such as multiple small tissues, broken tissues, tubular tissues, ESD strip tissues, etc., thereby filling the gap in the existing technology for equipment for dehydration and embedding treatments on special types of tissues.

[0121] At this time, if the rod 310 is used as the tissue fixing structure, see Fig.25 , a plurality of rods 310 may be provided corresponding to each placement area 112 to fix the pathological tissue in the placement area 112; if a pressing block 320 is used as a tissue fixing structure, there is no need to make additional modifications to the pressure cover 300, and the pressing block 320 may press the pathological tissues in several placement areas 112 at the same time.

[0122] In contrast, see Figure 5 The embedding groove 110 without the partitioning protrusion 111 is mainly aimed at relatively conventional pathological tissues. Only by changing the size of the embedding groove 110, it can be adapted to conventional pathological tissues in most cases.

[0123] It can be seen that the present application provides corresponding embedding grooves 110, embedding frames 200 and pressure covers 300 for various types of pathological tissues, which effectively improves the versatility and practicality of the integrated pathological tissue dehydration and embedding processor.

[0124] Specifically, in all the above embodiments, a plurality of supporting protrusions (not shown) are provided at the bottom of the embedding tank 110 to carry the pathological tissue so that the pathological tissue as a whole can be completely immersed in different reagents, resulting in a better treatment effect, which is beneficial to subsequent pathological analysis of sections and has high practical significance.

[0125] In a specific embodiment, see Figure 5 , Figure 6 , Fig.10 , Fig.13 , Figures 19 to 23 and Fig.25 , a mounting ear 340 is provided at the edge of the gland 300, and a fixing hole 341 is provided on the mounting ear 340. At the same time, a mounting hole is provided on the side of the embedded bottom mold 100 away from the gland 300, and a magnet 400 is provided in the mounting hole, and a limiting hole 120 is provided at the side of the embedded bottom mold 100 facing the gland 300 corresponding to the mounting hole, so that the mounting hole and the limiting hole 120 are arranged one by one. Among them, a locking piece is penetrated in the fixing hole 341, and one end of the locking piece is suitable for penetrating into the limiting hole 120 and being fixed by magnetic attraction with the magnet 400, so that the gland 300 and the embedded bottom mold 100 are elastically and movably connected. At this time, the embedding frame 200 is clamped between the gland 300 and the embedded bottom mold 100.

[0126] In this embodiment, the gland 300 and the embedding bottom mold 100 are connected by magnetic elastic activity, which makes assembly and disassembly more convenient. The operator can quickly position the locking piece into the installation hole provided with the magnet 400 to complete the alignment and fixation of the gland 300 and the embedding bottom mold 100; and when the wax liquid in the embedding groove 110 is about to solidify, the gland 300 can be quickly removed from the embedding bottom mold 100 to avoid the situation where the tissue fixing structure cannot be separated from the embedding groove 110. Among them, the limiting hole 120 can also play a certain guiding role, realizing the rapid alignment of the gland 300 and the embedding bottom mold 100, so that the gland 300 can be installed to the corresponding position. In addition, see Fig. 27 In this embodiment, the magnet 400 on the embedding bottom mold 100 can also be used to magnetically fix the baffle plate 500 on the side of the embedding bottom mold 100 away from the pressure cover 300, so that the baffle plate 500 can block the liquid flow hole 701 on the bottom of the embedding groove 110, and the structural setting is more reasonable and the utilization rate is high.

[0127] Specifically, see Figure 1 , Figure 3 , Fig.15 , Figures 19 to 23 and Fig.25, the number of mounting ears 340 on the gland 300 can be three. That is, two mounting ears 340 are provided on one edge of the gland 300; and a mounting ear 340 is provided on one edge of the gland 300 away from the side, and the mounting ear 340 is located between the two mounting ears 340 on the other side. At this time, when the magnets 400 and the limiting holes 120 are provided on the embedding bottom mold 100, the magnets 400 and the limiting holes 120 corresponding to two adjacent embedding grooves 110 can also be staggered, and at the same time, there will be no interference between the glands 300, which can achieve the effect of saving space.

[0128] Of course, in actual production, the number of mounting ears 340 can also be four. That is, two mounting ears 340 are provided on one edge of the gland 300; and two mounting ears 340 are also provided on the edge of the gland 300 away from the side, and these two mounting ears 340 are located between the two mounting ears 340 on the other side. At this time, when the magnets 400 and the limiting holes 120 are arranged on the embedding bottom mold 100, the magnets 400 and the limiting holes 120 corresponding to the two adjacent embedding grooves 110 can also be arranged alternately, and there will be no interference between the glands 300, which can achieve the effect of saving space. No further details are given here, and they are all within the protection scope of this application.

[0129] In a specific embodiment, see Figures 19 to 23 The locking member includes a screw rod 350 and a nut 360. The screw rod 350 is inserted into the fixing hole 341, and a magnetic attraction portion 351 is provided at one end of the screw rod 350 facing the embedded bottom mold 100. The magnetic attraction portion 351 is preferably made of a magnetic or iron material. The nut 360 is screwed on the end of the screw rod 350 away from the magnetic attraction portion 351. In addition, a spring 370 is provided on the outer sleeve of the screw rod 350, and the spring 370 is located between the mounting ear 340 and the nut 360.

[0130] When the magnetic attraction portion 351 is magnetically connected to the magnet 400, one end of the spring 370 is pressed against the mounting ear 340, and the other end of the spring 370 is pressed against the nut 360, thereby playing a certain buffering role, realizing the elastic pressing of the tissue fixing device on the gland 300 against the pathological tissue in the embedding groove 110, and it is not easy to crush the pathological tissue. More importantly, by introducing the spring 370, on the one hand, the tissue fixing structure can still be pressed against the pathological tissue after the dehydration and shrinkage, so as to realize the limited fixation of the pathological tissue, which is highly practical; on the other hand, the gland 300 and the tissue fixing structure thereon can better adapt to pathological tissues of different thicknesses, and have a wider range of applications. In this embodiment, the nut 360 can also be used to adjust the compression degree of the spring 370, further expanding the scope of application of the gland 300 and the tissue fixing structure thereon.

[0131] In actual production, the magnetic attraction portion 351 can be adapted to the outer contour of the screw 350, or can be larger than the outer contour of the screw 350 to increase the adsorption force between the magnetic attraction portion 351 and the magnet 400. This is not limited here and is within the protection scope of this application.

[0132] If the magnetic portion 351 is larger than the outer contour of the screw 350, then when assembling the locking piece to the fixing hole 341 on the pressure cover 300, the end of the screw 350 away from the magnetic portion 351 can be first inserted into the fixing hole 341 from the pressure cover 300 toward the side of the embedded bottom mold 100, and then the spring 370 is placed on the screw 350, and finally the nut 360 is screwed on to complete the assembly.

[0133] In a specific embodiment, see Figures 3 to 5 and Figure 7 and Figure 8 At least one set of buckle groups is provided on the embedding bottom mold 100, and each set of buckle groups includes a first buckle 130 and a second buckle 140 arranged oppositely. The first buckle 130 and the second buckle 140 respectively clamp the opposite sides of the embedding frame 200, thereby fixing the embedding frame 200 on the embedding bottom mold 100.

[0134] Specifically, see Fig. 9 , Fig.12 , Fig.17 and Fig.18 The embedding frame 200 includes a main board 210 and side boards. The main board 210 is rectangular in structure, and there are four side boards, which are respectively arranged on the four edges of the main board 210. The four side boards are the first side board 220, the second side board 230, the third side board 240 and the fourth side board 250, wherein the first side board 220 has a first inclined surface 221 on the side away from the third side board 240, which can be used for printing labels or handwriting labels, so as to facilitate identification by operators. In this embodiment, the main board 210 is suitable for covering the embedding groove 110, and the first avoidance hole 211 is arranged on the main board 210.

[0135] Further, see Figure 7 and Figure 8 The first buckle 130 has a second inclined surface 131 on one side facing the second buckle 140, and the second inclined surface 131 is arranged parallel to the first inclined surface 221, and the first buckle 130 is suitable for abutting the first side plate 220 of the embedding frame 200. And the second buckle 140 is arranged obliquely toward the first buckle 130 at one end away from the embedding bottom mold 100, and is suitable for abutting the third side plate 240 of the embedding frame 200.

[0136] See also Figure 4 , Fig. 9 , Fig.12 , Fig.17 and Fig.18In order to facilitate the operator to remove the embedding frame 200 from the embedding bottom mold 100, in one embodiment, a handle 241 is provided on the third side plate 240 of the embedding frame 200, which is away from the first side plate 220 and the end away from the embedding bottom mold 100. In this way, the operator can directly lift the handle 241 to realize the removal of the embedding frame 200, which is convenient for operation.

[0137] Specifically, see Figure 2 , Fig.16 , Fig.26 and Fig. 27 The pathological tissue dehydration and embedding integrated processor further includes a lifting plate 600, which is disposed between the pressure cover 300 and the embedding bottom mold 100, and the lifting plate 600 is provided with a second avoidance hole 610 for avoiding the embedding frame 200. When the lifting plate 600 moves in a direction away from the embedding bottom mold 100, the lifting plate 600 drives the pressure cover 300 to move in a direction away from the embedding bottom mold 100, thereby driving the tissue fixing structure to evacuate the embedding groove 110.

[0138] The present application provides a lifting plate 600 to simultaneously drive multiple pressure covers 300 to move together, thereby achieving synchronous processing of multiple pathological tissues, greatly improving the processing efficiency of pathological tissue dehydration and embedding, and having strong practicality.

[0139] Specifically, see Figure 1 , Figure 5 , Fig.15 and Fig.24 The embedding bottom mold 100 is provided with a plurality of embedding grooves 110 in the horizontal direction, and the plurality of embedding grooves 110 arranged in the horizontal direction are arranged in the vertical direction, forming a structure of embedding grooves 110 in multiple rows and columns on the embedding bottom mold 100, and each embedding groove 110 is covered with an embedding frame 200. At this time, see Fig.26 and Fig. 27 , the lifting plate 600 may be provided with a plurality of second avoidance holes 610 in the transverse direction, and each second avoidance hole 610 extends in the longitudinal direction, and can avoid a whole row of embedding frames 200 at the same time. Of course, the lifting plate 600 may also be provided with a plurality of second avoidance holes 610 in the longitudinal direction, and each second avoidance hole 610 extends in the transverse direction, and can avoid a whole row of embedding frames 200 at the same time, which will not be described in detail here, and all are within the protection scope of the present application.

[0140] Note that see Figure 1 , Figure 2 , Fig.15 and Fig.16 The edge of the pressure cover 300 should be able to overlap the area between two adjacent second avoidance holes 610 of the lifting plate 600, so that the lifting plate 600 can drive the pressure cover 300 to move together.

[0141] In one example embodiment, see Figure 1 , Figure 2 , Fig.10 , Fig.11 , Figures 13 to 16 and Figures 19 to 24 The edge of the pressure cover 300 is also provided with a lifting ear 380 to form a portion where the edge of the pressure cover 300 can overlap between two adjacent second avoidance holes 610 of the lifting plate 600, which is suitable for the lifting plate 600 to drive the pressure cover 300 to move away from the embedding bottom mold 100, thereby driving the tissue fixing structure to evacuate the embedding groove 110.

[0142] Specifically, the integrated pathological tissue dehydration and embedding processor may further include a refrigeration plate and a heat conduction plate, wherein the refrigeration plate is used to solidify the wax liquid in the embedding tank 110, and the heat conduction plate is used to heat the gland 300 to prevent the gland 300 from being solidified by the wax liquid, so as to facilitate the operator to remove the gland 300.

[0143] The present application also provides a method for dehydrating and embedding pathological tissue, which may specifically include the following steps:

[0144] 1) Placing the pathological tissue in the embedding groove 110 on the embedding bottom mold 100;

[0145] 2) Covering the embedding frame 200 on the embedding tank 110;

[0146] 3) placing the pressure cover 300 on the embedding frame 200, and allowing the tissue fixing structure on the pressure cover 300 to extend into the embedding tank 110 through the first avoidance hole 211 on the embedding frame 200, thereby pressing the pathological tissue;

[0147] 4) Dehydrating and wax-immersing the pathological tissue in the embedding tank 110;

[0148] 5) Cooling the wax liquid at the bottom of the embedding tank 110 and next to the pathological tissue;

[0149] 6) After the wax liquid at the bottom of the embedding tank 110 and next to the pathological tissue is initially solidified, the gland 300 is heated simultaneously;

[0150] 7) Remove the gland 300;

[0151] 8) After the wax liquid in the embedding tank 110 is completely solidified, the desired tissue wax block is formed.

[0152] Specifically, the operator first selects different embedding bottom molds 100, embedding frames 200 and pressure covers 300 according to the sizes and shapes of different pathological tissues. Then, the pathological tissue is placed in the corresponding embedding groove 110 according to the pathological embedding requirements. Next, the embedding frame 200 is buckled on top of the embedding groove 110. Subsequently, the pressure cover 300 is placed on the embedding frame 200, and the rod 310 or the pressing block 320 on the pressure cover 300 will pass through the first avoidance hole 211 on the embedding frame 200 and press the pathological tissue in the embedding groove 110; at the same time, the end of the locking piece on the pressure cover 300 is automatically introduced into the corresponding limiting hole 120 and fixed under the adsorption action of the magnet 400. At this time, the pathological tissue in the embedding groove 110 is elastically pressed by the tissue fixing structure on the pressure cover 300, and the force applied is relatively gentle and not easy to be crushed.

[0153] After the operator assembles the embedding bottom mold 100, the embedding frame 200 and the gland 300, the assembled components need to be placed in a reagent tank so that they are immersed in different reagents in steps. Because the bottom of the embedding tank 110 is provided with a flow hole 701, the reagent in the reagent tank can enter the embedding tank 110, thereby achieving the work of dehydrating, transparentizing, and waxing the pathological tissue. Specifically, this operation can be completed by manual operation or by using a dedicated dehydrating machine, which will not be described in detail here, and all are within the scope of protection of this application.

[0154] After the wax dipping is completed, the baffle plate 500 is first fixed to the side of the embedding bottom mold 100 away from the embedding frame 200 and the pressure cover 300 to close the flow hole 701 on the bottom of the embedding tank 110, and the wax liquid is retained in the embedding tank 110. At the same time, the excess wax liquid can flow out from the flow hole 701 on the embedding frame 200 and the pressure cover 300. If a pressing block 320 is provided on the pressure cover 300 to form a tissue fixing structure, the excess wax liquid can also flow out from the flow hole 701 on the pressing block 320. Afterwards, the assembled baffle plate 500, the embedding bottom mold 100, the embedding frame 200 and the pressure cover 300 are taken out of the reagent tank together.

[0155] Next, the assembled baffle plate 500, embedding bottom mold 100, embedding frame 200 and gland 300 are placed in a cold table or inserted into a refrigeration plate. At this time, the wax liquid located at the bottom of the embedding tank 110 and next to the pathological tissue will solidify when it is cold, thereby fixing the pathological tissue. When the upper wax liquid has not yet completely solidified, the heat conducting plate is placed close to the gland 300 to direct the heat to the side of the gland 300 toward the embedding bottom mold 100. In this way, the tissue fixing structure on the gland 300 will not be fixed in the embedding tank 110 by the wax liquid, and the operator can gently lift the gland 300 through the lifting plate 600 to separate the tissue fixing structure on it from the embedding tank 110.

[0156] Finally, cooling is continued until the wax liquid in the embedding tank 110 is completely solidified, and the desired tissue wax block can be obtained. The operator takes out the tissue wax block and places it on a microtome for slicing.

[0157] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0158] It should be noted that the above embodiments can be freely combined as needed. The above are only preferred implementations of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application, and these improvements and modifications should also be regarded as the protection scope of the present application.

Claims

1. A pathological tissue dehydration and embedding integrated processor, characterized in that: include: An embedding bottom mold, wherein the embedding bottom mold is provided with at least one embedding groove, and the embedding groove is suitable for accommodating pathological tissue; An embedding frame, covering the embedding groove; A gland, located at a side of the embedding frame away from the embedding bottom mold, and the gland is provided with a tissue fixing structure; The embedding frame is provided with a first avoidance hole corresponding to the tissue fixing structure, so that the tissue fixing structure can extend into the embedding groove to fix the pathological tissue; When the wax liquid at the bottom layer and around the pathological tissue in the embedding groove is initially solidified, the pressure cover moves away from the embedding bottom mold, and the tissue fixing structure withdraws from the embedding groove.

2. The integrated pathological tissue dehydration and embedding processor according to claim 1, characterized in that: A plurality of rods are provided on one side of the gland facing the embedding frame to form the tissue fixing structure; or A pressing block is provided on one side of the pressing cover facing the embedding frame to form the tissue fixing structure.

3. The integrated pathological tissue dehydration and embedding processor according to claim 2, characterized in that: The rod on the gland includes a limiting rod and a fixing rod, the fixing rod is arranged around the limiting rod, and the length of the fixing rod is greater than the length of the limiting rod; Wherein, the limiting rod is suitable for avoiding the pathological area in the pathological tissue, and the fixing rod is suitable for pressing the normal area in the pathological tissue; or A weight-reducing groove is provided on one side of the pressure cover away from the embedding frame at a position corresponding to the pressure block, and a weight-reducing hole is provided on the side wall of the pressure block and connected to the weight-reducing groove; The end face of the pressing block and the area of ​​the pressing block side wall close to the end face of the pressing block are both provided with flow holes connected to the weight reduction groove, and the end face of the pressing block is rectangular or circular; and / or, the end face of the pressing block is provided with a plurality of protrusions, which are suitable for pressing against the pathological tissue and forming a gap between the pressing block and the pathological tissue for fluid flow.

4. The integrated processor for dehydration and embedding of pathological tissue according to any one of claims 1 to 3, characterized in that: The bottom of the embedding groove is provided with a plurality of partitioning protrusions, and the plurality of partitioning protrusions are arranged in sequence to divide the embedding groove into at least two placement areas; The placement area is circular, rectangular or strip-shaped; and / or The bottom of the embedding groove is provided with a plurality of supporting protrusions for carrying the pathological tissue.

5. The integrated processor for dehydration and embedding of pathological tissue according to any one of claims 1 to 3, characterized in that: The edge of the gland is provided with a mounting ear, a fixing hole is provided on the mounting ear, a locking piece is passed through the fixing hole, and the locking piece includes a screw and a nut; the screw is passed through the fixing hole, and a magnetic attraction portion is provided at one end of the screw facing the embedded bottom mold, and the nut is screwed on the end of the screw away from the magnetic attraction portion; and a spring is provided on the outer sleeve of the screw, and the spring is located between the mounting ear and the nut; A mounting hole is provided on a side of the embedded bottom mold away from the gland, a magnet is provided in the mounting hole, and a limiting hole is provided on a side of the embedded bottom mold facing the gland, the limiting hole and the mounting hole are arranged in a one-to-one correspondence; The magnet is used to absorb the magnetic attraction part into the limiting hole. When the magnetic attraction part is magnetically connected to the magnet, one end of the spring is pressed against the mounting ear, and the other end of the spring is pressed against the nut, so that the gland is elastically and movably connected to the embedded bottom mold, and the nut is suitable for adjusting the compression degree of the spring; and The edge of the pressure cover is also provided with a lifting ear, which is suitable for the lifting plate to drive the pressure cover to move in a direction away from the embedding bottom mold, thereby driving the tissue fixing structure to evacuate the embedding groove.

6. The integrated pathological tissue dehydration and embedding processor according to any one of claims 1 to 3, characterized in that: The embedding frame includes a main board and side boards; The main board is in a rectangular structure, and the number of the side panels is four, which are respectively arranged on the four edges of the main board; and the four side panels are sequentially a first side panel, a second side panel, a third side panel and a fourth side panel, and the first side panel has a first inclined surface on a side away from the third side panel; The main board is suitable for covering the embedding groove, and the main board is provided with the first avoidance hole.

7. The integrated pathological tissue dehydration and embedding processor according to claim 6, characterized in that: The embedding bottom mold is provided with at least one set of buckle groups for fixing the embedding frame; Each of the buckle groups includes a first buckle and a second buckle that are arranged opposite to each other, the first buckle has a second inclined surface on a side facing the second buckle, and the second inclined surface is arranged parallel to the first inclined surface, and the first buckle is suitable for abutting against the first side plate of the embedding frame; and, the second buckle is inclinedly arranged at one end away from the embedding bottom mold toward the first buckle, and is suitable for abutting against the third side plate of the embedding frame; A handle is provided on the third side plate of the embedding frame, which is away from the first side plate and at one end of the embedding bottom mold.

8. The integrated pathological tissue dehydration and embedding processor according to any one of claims 1 to 3, characterized in that: Also includes: Baffles; The embedding groove bottom is provided with a plurality of flow holes; and / or, the embedding bottom mold is provided with a plurality of flow holes around the embedding groove; and / or, the embedding frame is provided with a plurality of flow holes at a portion suitable for covering the embedding groove; and / or, the pressure cover is provided with a plurality of flow holes; and the flow holes are in a circular or strip-shaped hole structure; The baffle plate is located at a side of the embedding bottom mold away from the embedding frame, and is suitable for blocking the liquid flow hole on the embedding bottom mold.

9. The integrated pathological tissue dehydration and embedding processor according to any one of claims 1 to 3, characterized in that: Also includes: A lifting plate is arranged between the pressure cover and the embedding bottom mold, and the lifting plate is provided with a second avoidance hole for avoiding the embedding frame; When the lifting plate moves in a direction away from the embedding bottom mold, the lifting plate drives the pressure cover to move in a direction away from the embedding bottom mold, thereby driving the tissue fixing structure to evacuate the embedding groove; and / or Refrigeration plate and heat conducting plate; The refrigeration plate is used to solidify the wax liquid in the embedding tank, and the heat conduction plate is used to heat the gland.

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