Improved porous magnetic separation frame

Abstract

The utility model relates to an improved porous magnetic separation frame applied to the technical field of magnetic force frames, which comprises a base, a supporting plate fixedly connected to the top end of the base, a clamping plate sleeved on the supporting plate, a plurality of first clamping grooves symmetrically formed in the top end of the clamping plate, a plurality of inner grooves annularly formed in the inner walls of the first clamping grooves at equal intervals, and extension springs fixedly connected in the inner grooves. By the adoption of the adjusting structure, when the magnetic separation frame is used, a reagent tube can be inserted into the first clamping groove, the clamping plates are propped open through extrusion, meanwhile, the clamping plates abut against the outer wall of the reagent tube through telescopic adjustment of the extension springs, the reagent tube is clamped, and after the reagent tube is fixed, the reagent tube can be fixed according to the distance between the reagent tube and the supporting plate. A connecting plate is slidably adjusted in a sliding groove, so that a magnet is in contact with a reagent tube to enrich a magnetic material of a to-be-separated sample from a solution, and the effect that the size of a first clamping groove can be automatically adjusted according to the sizes of different reagent tubes, so that the first clamping groove is fixedly clamped is effectively achieved.

Description

Technical Field

[0001] The utility model relates to an improved porous magnetic separation frame, in particular to an improved porous magnetic separation frame applied in the technical field of magnetic frames. Background Art

[0002] The magnetic separation device, also known as the magnetic separation rack, magnetic separation rack, magnetic bead separation rack or magnetic rack, is mainly used for the rapid solid-liquid separation of magnetic particles. It is an essential device for experiments such as nucleic acid extraction or purification, antibody or protein purification, and immunoprecipitation based on the magnetic bead method. The general process of magnetic separation is to add magnetic materials that can bind to the sample to be separated into a solution containing the sample to be separated. After the magnetic material is fully combined with the sample to be separated, an external magnetic field is applied to the solution through the magnetic separation rack. Under the action of the external magnetic field, the magnetic material bound to the sample to be separated is enriched from the solution, thereby achieving the separation of the sample to be separated.

[0003] The specification of Chinese patent CN207330906U discloses a porous magnetic frame that is convenient for separation, including a magnetic frame for connecting test tubes and a base connected with a plurality of magnets, the magnetic frame including a connecting plate with a plurality of through hole groups and a fixed plate for connecting the base, each through hole group including four through holes, the through holes being used to connect the test tubes, the fixed plate being connected with a plurality of connecting grooves, the number of the connecting grooves, the through hole groups and the magnets being the same, when connected, the magnets on the base pass through the connecting grooves, and the four through holes in each through hole group surround a magnet, the utility model solves the problems of cumbersome operation, heavy weight and low efficiency when using the magnetic frame.

[0004] The specification of Chinese patent CN212688084U discloses a porous magnetic rack that can be quickly separated, including a magnetic rack frame, a top plate fixedly installed on the top of the magnetic rack frame, a support column installed on the top relative to the magnetic rack frame and the top plate, a sliding rod fixedly connected between the two support columns, a sliding sleeve of an external movable sleeve joint of the sliding rod, and a magnetic cylinder fixedly connected to the left side of the sliding sleeve, by fixing the position of the sliding sleeve on the surface of the sliding rod, at this time, any one of the magnetic wrapping adsorption grooves 1, 2 or 3 on the outside of the rotating column magnetically adsorbs the material at the bottom part of the reagent tube to meet the magnetic adsorption requirements of the magnetic rack, when magnetic adsorption is not required, the sliding sleeve is slid backward along the sliding rod to drive the rotating column to separate from the reagent tube, thereby achieving the effect that the magnet can be quickly changed and separated.

[0005] The slots in the existing magnetic separation racks are all of fixed size and cannot be used for reagent tubes of different sizes. Each time the magnetic separation rack is used, a matching magnetic separation rack must be selected according to the size of the reagent tube, which causes inconvenience. Utility Model Content

[0006] In view of the above-mentioned prior art, the technical problem to be solved by the utility model is that the slots in the existing magnetic separation racks are all of fixed size and cannot be used for reagent tubes of different sizes. Each time they are used, a magnetic separation rack that matches the size of the reagent tube must be selected, which causes inconvenience.

[0007] In order to solve the above problems, the utility model provides an improved porous magnetic separation frame, including a base, a support plate fixedly connected to the top of the base, a card plate sleeved on the support plate, a plurality of first card grooves symmetrically opened on the top of the card plate, a plurality of inner grooves equidistantly opened in a circular shape on the inner wall of the first card groove, a tension spring fixedly connected in the inner groove, a splint fixedly connected at one end of the tension spring away from the inner groove, a reagent tube detachably connected in the first card groove, and the splint contacts the outer wall of the reagent tube, a sliding groove is opened on the side end of the support plate, a connecting plate is symmetrically slidably connected in the sliding groove, and magnets corresponding to the first card groove are fixedly connected to the connecting plate at equal intervals.

[0008] In the above-mentioned porous magnetic separation rack, the size of the first card slot can be automatically adjusted according to the size of different reagent tubes, thereby fixing and clamping them.

[0009] As a further improvement of the present application, a first groove is formed at the top of the clamping plate, and the first groove is engaged with the support plate.

[0010] As a further improvement of the present application, a plurality of second grooves are symmetrically and equidistantly excavated at both ends of the support plate, and a support plate is rotatably connected to the second groove via a damping shaft.

[0011] As a further improvement of the present application, the support plate is engaged with the second groove, and when the support plate is rotated to a vertical state, it abuts against the bottom end of the clamping plate.

[0012] As another improvement of the present application, a plurality of groups of telescopic rods are fixedly connected between the two connecting plates, and push plates are symmetrically fixedly connected to the top ends of the two telescopic rods located in the middle.

[0013] As another improved supplement of the present application, a second slot corresponding to the stretched state of the telescopic rod is bored at the top of the support plate, and the push plate passes through the second slot to the top of the support plate.

[0014] As another improved supplement of the present application, the telescopic rod is designed in three sections, and the push plates are located at the top ends of the left and right sections of the telescopic rod.

[0015] To sum up, this solution can be realized. When using the magnetic separation rack, the reagent tube can be inserted into the first card slot, and the clamp can be stretched open by squeezing. At the same time, the clamp can be adjusted to contact the outer wall of the reagent tube through the tension spring to clamp the reagent tube. After the reagent tube is fixed, the connecting plate is slid and adjusted in the slide groove according to the distance between the reagent tube and the support plate, so that the magnet on the connecting plate contacts the outer wall of the reagent tube to enrich the magnetic material of the sample to be separated from the solution, thereby effectively achieving the effect of automatically adjusting the size of the first card slot according to the size of different reagent tubes, thereby fixing and clamping them. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is an axonometric diagram of the separation frame of the first and second embodiments of the present application;

[0017] Figure 2 For this application Figure 1 Enlarged view of point A in the middle;

[0018] Figure 3 For this application Figure 1 Enlarged view of point B in the middle;

[0019] Figure 4 This is a card slot structure diagram of the first implementation mode of this application;

[0020] Figure 5 This is a structural diagram of a connecting plate according to a second embodiment of the present application;

[0021] Figure 6 This is a partial structural diagram of a connecting plate according to a second embodiment of the present application;

[0022] Figure 7 This is a structural diagram of a support plate according to the second embodiment of the present application.

[0023] Description of the numbers in the figure:

[0024] 1. Base; 2. Support plate; 3. Card plate; 4. First card slot; 5. First groove; 6. Push plate; 7. Magnet; 8. Reagent tube; 9. Inner groove; 10. Tension spring; 11. Clamp; 12. Connecting plate; 13. Slide; 14. Second groove; 15. Support plate; 16. Telescopic rod; 17. Damping shaft. DETAILED DESCRIPTION

[0025] Two implementation modes of the present application are described in detail below with reference to the accompanying drawings.

[0026] The first implementation method:

[0027] Figure 1-2 and Figure 4An improved porous magnetic separation frame is shown, comprising a base 1, a support plate 2 is fixedly connected to the top of the base 1, a card plate 3 is sleeved on the support plate 2, a plurality of first card grooves 4 are symmetrically opened on the top of the card plate 3, a plurality of inner grooves 9 are equidistantly opened in an annular manner on the inner wall of the first card groove 4, a tension spring 10 is fixedly connected in the inner groove 9, a clamping plate 11 is fixedly connected at one end of the tension spring 10 away from the inner groove 9, a reagent tube 8 is detachably connected in the first card groove 4, and the clamping plate 11 is in conflict with the outer wall of the reagent tube 8, a slide groove 13 is opened on the side end of the support plate 2, a connecting plate 12 is symmetrically slidably connected in the slide groove 13, and magnets 7 corresponding to the first card groove 4 are fixedly connected to the connecting plate 12 at equidistant intervals.

[0028] This solution can be achieved. When using the magnetic separation rack, the reagent tube 8 can be inserted into the first card slot 4, and the clamp 11 can be stretched open by squeezing. At the same time, the clamp 11 is adjusted to contact the outer wall of the reagent tube 8 through the tension spring 10 to clamp the reagent tube 8. After the reagent tube 8 is fixed, the connecting plate 12 is slid and adjusted in the slide groove 13 according to the distance between the reagent tube 8 and the support plate 2, so that the magnet 7 on the connecting plate 12 contacts the outer wall of the reagent tube 8 to enrich the magnetic material of the sample to be separated from the solution, and the size of the first card slot 4 can be automatically adjusted according to the size of different reagent tubes 8, thereby fixing and clamping them.

[0029] The second implementation method:

[0030] Figure 1-3 and Figure 5-7 It is shown that a first groove 5 is chiseled at the top of the card plate 3, and the first groove 5 is engaged with the support plate 2, and a plurality of second grooves 14 are symmetrically and equidistantly chiseled at both ends of the support plate 2, a support plate 15 is rotatably connected in the second groove 14 through a damping shaft 17, the support plate 15 is engaged with the second groove 14, and the support plate 15 is in conflict with the bottom end of the card plate 3 when it is rotated to a vertical state, a plurality of groups of telescopic rods 16 are fixedly connected between the two connecting plates 12, and push plates 6 are symmetrically fixedly connected to the tops of the two telescopic rods 16 in the middle, a second slot corresponding to the telescopic rod 16 in the stretched state is chiseled at the top of the support plate 2, and the push plate 6 passes through the second slot to the top of the support plate 2, the telescopic rod 16 is a three-section design, and the push plate 6 is located at the top of the left and right sections of the telescopic rod 16.

[0031] This solution allows, when the reagent capacity in the reagent tube 8 is small or large, the card plate 3 can be slid up and down on the support plate 2 through the first groove 5 according to the amount of reagent, thereby driving the reagent tube 8 in the first card slot 4 to adjust its height. After adjusting to the appropriate position, the support plate 15 in the second groove 14 corresponding to the support plate 2 can be flipped ninety degrees through the damping shaft 17, and the support plate 2 can be lifted up for positioning, thereby effectively achieving the free adjustment of the height of the card plate 3, ensuring that reagents of different capacities can contact the magnet 7 for magnetic separation, and then according to the distance between the magnet 7 and the reagent tube 8, the two push plates 6 are held apart to stretch the telescopic rod 16, so that the connecting plate 12 drives the magnet 7 to move and contact the reagent tube 8, effectively achieving the free adjustment of the position of the magnet 7 according to the size of the reagent tube 8, ensuring that the reagent tube 8 and the magnet 7 are in a fitted state.

[0032] In view of current practical needs, the protection scope of the above-mentioned implementation mode adopted in this application is not limited to this. Various changes made within the knowledge scope of technical personnel in this field without departing from the concept of this application still fall within the protection scope of this utility model.

Claims

1. An improved porous magnetic separation rack, comprising a base (1), characterized in that: The top of the base (1) is fixedly connected to a support plate (2), the support plate (2) is sleeved with a card plate (3), the top of the card plate (3) is symmetrically opened with a plurality of first card grooves (4), the inner wall of the first card groove (4) is annularly opened with a plurality of inner grooves (9) at equal intervals, a tension spring (10) is fixedly connected in the inner groove (9), the tension spring (10) is fixedly connected to one end away from the inner groove (9) with a clamping plate (11), the first card groove (4) is detachably connected with a reagent tube (8), and the clamping plate (11) is in contact with the outer wall of the reagent tube (8), a sliding groove (13) is opened at the side end of the support plate (2), a connecting plate (12) is symmetrically slidably connected in the sliding groove (13), and magnets (7) corresponding to the first card groove (4) are fixedly connected to the connecting plate (12) at equal intervals.

2. The improved porous magnetic separation rack according to claim 1, characterized in that: A first groove (5) is formed at the top of the clamping plate (3), and the first groove (5) is clamped with the supporting plate (2).

3. The improved porous magnetic separation rack according to claim 1, characterized in that: A plurality of second grooves (14) are symmetrically and equidistantly excavated at both ends of the support plate (2), and a support plate (15) is rotatably connected in the second groove (14) via a damping shaft (17).

4. The improved porous magnetic separation rack according to claim 3, characterized in that: The support plate (15) is engaged with the second groove (14), and when the support plate (15) is rotated to a vertical state, it abuts against the bottom end of the clamping plate (3).

5. The improved porous magnetic separation rack according to claim 1, characterized in that: A plurality of groups of telescopic rods (16) are fixedly connected between the two connecting plates (12), and push plates (6) are symmetrically fixedly connected to the top ends of the two telescopic rods (16) located in the middle.

6. The improved porous magnetic separation rack according to claim 5, characterized in that: The top of the support plate (2) is provided with a second slot corresponding to the telescopic rod (16) in the stretched state, and the push plate (6) passes through the second slot to the top of the support plate (2).

7. The improved porous magnetic separation rack according to claim 5, characterized in that: The telescopic rod (16) is of three-section design, and the push plate (6) is located at the top of the left and right sections of the telescopic rod (16).

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