Ultrahigh-precision adjusting device and micro-fluidic chip manufacturing device
By designing an ultra-high-precision adjustment device including a stepper motor, a screw nut and a tapered positioning pin, the problem of low accuracy in microfluidic chip production is solved, and high-precision front and rear position adjustment is achieved.
Patent Information
- Application Number
- CN202420431217.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-06
- Publication Date
- 2025-02-21
- Estimated Expiration
- 2034-03-06
AI Technical Summary
During the production process of existing microfluidic chips, the adjustment accuracy of the piezoelectric motor can only reach 50nm level, which is not high and is inconvenient to use.
An ultra-high precision adjustment device is designed, including a stepper motor, a base plate, a push assembly, a adjustment assembly, a PD sensor and a control unit. The stepper motor drives the screw nut to move, the positioning pin bracket and the conical positioning pin move up and down, and the conical positioning pin contacts the positioning hole on the microfluidic chip, achieving high-precision front and rear position adjustment of the microfluidic chip.
The high-precision front and rear position adjustment of the microfluidic chip is realized, and the accuracy reaches nm level, solving the problem of low accuracy in the existing technology.
Smart Images
Figure CN222510959U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of microfluidic chip manufacturing, in particular to an ultra-high precision adjustment device and a microfluidic chip manufacturing device. Background Art
[0002] Microfluidic chip technology integrates the basic operating units of biological, chemical and medical analysis processes such as sample preparation, reaction, separation and detection into a micron-scale chip to automatically complete the entire analysis process.
[0003] In the production process of microfluidic chips, piezoelectric motors are usually used to adjust the position of microfluidic chips. However, the adjustment accuracy of piezoelectric motors can only reach 50nm (nanometer) level, which is not only low in accuracy but also inconvenient to use. Therefore, an ultra-high precision adjustment device and a microfluidic chip manufacturing device are proposed to solve the above problems. Utility Model Content
[0004] The utility model aims to overcome the existing defects and provide an ultra-high precision adjustment device and a microfluidic chip manufacturing device, so as to achieve high-precision front and rear position adjustment of the microfluidic chip.
[0005] The technical solution to achieve the above object is: an ultra-high precision adjustment device, comprising: a stepping motor, a base plate, a driving component, an adjustment component, a PD sensor and a control unit;
[0006] The stepper motor is mounted on the bottom plate, the output end of the stepper motor is connected to the pushing component, and the pushing component is connected to the adjusting component;
[0007] Wherein, a conical positioning pin is arranged on the side of the adjustment component facing the microfluidic chip, a positioning hole is arranged on the microfluidic chip, the conical positioning pin is arranged in a one-to-one correspondence with the positioning hole, and the conical positioning pin is inserted into the positioning hole of the microfluidic chip to fine-tune the position of the microfluidic chip;
[0008] The stepper motor and the PD sensor are both electrically connected to the control unit. The PD sensor is used to sense the microchannel position of the microfluidic chip. The control unit is used to receive the sensing signal of the PD sensor and control the downward movement distance of the conical positioning pin according to the sensing signal.
[0009] The pushing assembly comprises a screw rod, the upper end of which is connected to the output end of the stepping motor, and a screw rod nut is arranged on the screw rod, and the screw rod nut is connected to the adjusting assembly.
[0010] The pushing assembly also includes a linear guide rail, which is mounted on the base plate and is arranged parallel to the lead screw, and the lead screw nut is slidably connected to the linear guide rail.
[0011] The adjustment assembly includes a positioning pin bracket, which includes a first end, a second end, and a cross plate located between the first end and the second end, the first end is used to connect the screw nut, the second end is slidably connected to the base plate, the cross plate maintains a preset distance from the base plate, and two conical positioning pins are provided on the lower end surface of the cross plate.
[0012] Also included: microfluidic chip tray and micro switch;
[0013] The microfluidic chip tray and the micro switch are both installed on the base plate and located below the positioning pin bracket; the microfluidic chip tray is used to carry the microfluidic chip and limit the left and right movement of the microfluidic chip, and the micro switch is used to monitor whether the microfluidic chip reaches the fine-tuning position.
[0014] It also includes a guide seat, which is fixed on the base plate. The guide seat has a slide groove, the extension direction of the slide groove is parallel to the extension direction of the screw rod, and the end of the positioning pin bracket away from the screw rod nut is slidably set in the slide groove of the guide seat.
[0015] The left and right ends of the screw nut are each slidably connected to a guide rod, the two guide rods are arranged parallel to the screw, and the upper and lower ends of the guide rod are fixed on a mounting seat, the mounting seat is fixed on the base plate, the lower end of the screw is connected to a bearing, and the bearing is fixed on the mounting seat.
[0016] A position sensor is installed on the base plate, and the position sensor is used to detect the position of the screw nut. The control unit is electrically connected to the position sensor, and the control unit is used to receive a detection signal from the position sensor and control the movement range of the screw nut according to the detection signal.
[0017] A manufacturing device for a microfluidic chip comprises the ultra-high precision adjustment device.
[0018] The beneficial effect of the utility model is that the ultra-high precision adjustment device drives the screw nut to move by arranging a stepper motor, and the movement of the screw nut causes the positioning pin bracket and the tapered positioning pin to move up and down, and the tapered positioning pin moves downward and contacts and rubs with the two positioning holes on the microfluidic chip through the tapered surface, thereby driving the microfluidic chip to move slightly to the rear position, thereby realizing high-precision front and rear position adjustment. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 It is a schematic diagram of the ultra-high precision adjustment device of the utility model;
[0020] Figure 2 yes Figure 1 Enlarged view of point A in the middle;
[0021] Figure 3 It is a schematic diagram of the utility model when the conical positioning pin is used to fine-tune the position of the microfluidic chip.
[0022] In the figure: 1. stepper motor; 2. linear guide; 3. position sensor; 4. microfluidic chip tray; 5. microfluidic chip; 6. conical positioning pin; 7. positioning pin bracket; 8. guide seat; 9. screw rod; 10. screw rod nut; 11. bottom plate; 12. positioning hole; 13. guide rod. DETAILED DESCRIPTION
[0023] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.
[0024] The utility model will be further described below in conjunction with the accompanying drawings.
[0025] like Figure 1-3 As shown, an ultra-high precision adjustment device includes: a stepping motor 1, a base plate 11, a pushing component, an adjustment component, a PD sensor (not shown in the figure) and a control unit (not shown in the figure);
[0026] The stepper motor 1 is mounted on the bottom plate 11, the output end of the stepper motor 1 is connected to the pushing component, and the pushing component is connected to the adjusting component;
[0027] Among them, a conical positioning pin 6 is provided on the side of the adjustment component facing the microfluidic chip 5, and a positioning hole 12 is provided on the microfluidic chip 5. The conical positioning pin 6 and the positioning hole 12 are arranged one by one. The conical positioning pin 6 is inserted into the positioning hole 12 of the microfluidic chip 5 to fine-tune the position of the microfluidic chip 5;
[0028] The stepper motor 1 and the PD sensor are both electrically connected to the control unit. The PD sensor is used to sense the microchannel position of the microfluidic chip 5. The control unit is used to receive the sensing signal of the PD sensor and control the downward movement distance of the conical positioning pin 6 according to the sensing signal.
[0029] Specifically, the pushing assembly includes a screw rod 9, the upper end of the screw rod 9 is connected to the output end of the stepper motor 1, and a screw rod nut 10 is arranged on the screw rod 9, and the screw rod nut 10 is connected to the adjustment assembly.
[0030] The pushing assembly further comprises a linear guide rail 2 , which is mounted on a base plate 11 , and a lead screw nut 10 is slidably connected to the linear guide rail 2 .
[0031] The adjustment assembly includes a positioning pin bracket 7, which includes a first end, a second end, and a cross plate located between the first end and the second end. The first end is used to connect the screw nut 10, and the second end is slidably connected to the base plate 11. The cross plate maintains a preset distance with the base plate 11, and two conical positioning pins 6 are provided on the lower end surface of the cross plate.
[0032] Preferably, the first end, the second end and the cross plate of the positioning pin bracket 7 are connected as one body.
[0033] In this embodiment, the bottom plate 11 is vertically arranged, the horizontal plate of the positioning pin bracket 7 is horizontally arranged, and the microfluidic chip 5 is located below the horizontal plate.
[0034] In this embodiment, two positioning holes 12 are provided on the microfluidic chip 5 , and the distance d2 between the two positioning holes 12 is equal to the distance d1 between the two tapered positioning pins 6 .
[0035] When the stepper motor 1 drives the lead screw 9 to rotate, the lead screw nut 10 drives the positioning pin bracket 7 to move up and down along the linear guide rail 2.
[0036] When the positioning pin bracket 7 moves downward, the tapered positioning pin 6 is inserted into the positioning hole 12 of the microfluidic chip 5 .
[0037] The ultra-high precision adjustment device also includes: a microfluidic chip tray 4 and a micro switch (not shown in the figure);
[0038] The microfluidic chip tray 4 and the micro switch are both installed on the base plate 11 and located below the positioning pin bracket 7; the microfluidic chip tray 4 is used to carry the microfluidic chip 5 and limit the left and right movement of the microfluidic chip 5, and the micro switch is used to monitor whether the microfluidic chip 5 reaches the fine-tuning position.
[0039] When the microfluidic chip 5 contacts the micro switch, it means that the microfluidic chip 5 reaches the fine-tuning position, and the PD sensor (ie, the optical signal detection sensor) starts to detect the microchannel position of the microfluidic chip 5 .
[0040] The setting of the micro switch allows the microfluidic chip 5 to be positioned forward, and the deviation range is generally within 2 mm. When the conical positioning pin 6 moves downward, it will contact the inner wall of the positioning hole 12 and push the microfluidic chip 5 to move backward, thereby fine-tuning the position of the microfluidic chip 5. In this process, the control unit controls the downward movement distance of the conical positioning pin 6 according to the sensing signal of the PD sensor until the PD sensor detects that the center position of the microchannel coincides with the center position of the light spot.
[0041] It also includes a guide seat 8, which is fixed on the base plate 11. The guide seat 8 has a slide groove, and the extension direction of the slide groove is parallel to the extension direction of the linear guide rail 2. The end of the positioning pin bracket 7 away from the screw nut 10 is slidably set in the slide groove of the guide seat 8.
[0042] In another embodiment, if the thickness of the bottom plate 11 is sufficient, the slide groove may be directly opened on the bottom plate 11 without providing the guide seat 8 .
[0043] The left and right ends of the screw nut 10 are slidably connected to a guide rod 13, and the two guide rods 13 are arranged parallel to the screw 9, and the upper and lower ends of the guide rod 13 are fixed on the mounting seat, the mounting seat is fixed on the base plate 11, and the lower end of the screw 9 is connected to the bearing, and the bearing is fixed on the mounting seat.
[0044] A position sensor 3 is installed on the base plate 11 , and the position sensor 3 is used to detect the position of the screw nut 10 . The control unit is electrically connected to the position sensor 3 , and the control unit is used to receive a detection signal from the position sensor 3 and control the movement range of the screw nut 10 according to the detection signal.
[0045] When the screw nut 10 moves downward to the limit position, the control unit issues a control command to stop moving.
[0046] In this embodiment, two position sensors 3 are respectively arranged at the initial position and the limit position of the screw nut 10. Under the control of the control unit, the screw nut 10 can only move back and forth between the initial position and the limit position.
[0047] Correspondingly, this embodiment also provides a microfluidic chip manufacturing device, including the ultra-high precision adjustment device as described above.
[0048] Specifically, the microfluidic chip 5 can only slide in the front-to-back direction on the microfluidic chip tray 4 due to the left-right position limitation, and the tapered positioning pin 6 is positioned and matched with the two positioning holes 12 on the microfluidic chip 5 .
[0049] Specifically, the overall implementation steps are that the stepper motor 1 drives the lead screw nut 10 to move, and the movement of the lead screw nut 10 causes the positioning pin bracket 7 and the conical positioning pin 6 to move up and down, and the conical positioning pin 6 moves downward and contacts and rubs with the two positioning holes 12 on the microfluidic chip 5 through the conical surface, driving the microfluidic chip 5 to move slightly to the rear position, thereby realizing high-precision front and rear position adjustment.
[0050] Specifically, the stepper motor 1 has a step angle of 1.8° according to the stepper motor characteristics. Assuming 64 subdivisions are used, the stepper motor can achieve 1.8° / 64 movement each time. The pitch of the screw rod 9 is L. The stepper motor 1 can achieve a longitudinal movement of the screw nut 10 of L×1.8° / (64×360) in each subdivision. If the cone angle of the tapered locating pin 6 is 2θ, each step angle can achieve a lateral movement of tan(θ)×L×1.8° / (64×360).
[0051] For example, if the L pitch is 2mm and the cone angle of the tapered positioning pin 6 is 30°, the θ angle is 15° and the minimum lateral displacement is 0.04μm. The angle θ can be processed according to the requirements and the pitch L can also be selected according to the requirements. The existing stepper motor pitch is generally 2, 4, 8mm, etc. The θ angle is within 15°, which can achieve at least nm-level adjustment accuracy.
[0052] In the embodiment, a position sensor 3 is respectively arranged at the upper and lower ends of the bottom plate 11, for real-time detection of the position of the screw nut 10. The position sensor is an existing device, model PS-105.
[0053] The above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit it. Although the utility model is described in detail with reference to the above embodiments, ordinary technicians in this field should understand that they can still modify the technical solutions recorded in the above embodiments, or replace some or all of the technical features therein with equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the utility model.
Claims
1. An ultra-high precision adjustment device, characterized in that: include: A stepping motor (1), a base plate (11), a driving component, an adjustment component, a PD sensor and a control unit; The stepper motor (1) is mounted on the base plate (11), the output end of the stepper motor (1) is connected to the pushing component, and the pushing component is connected to the adjusting component; Wherein, a conical positioning pin (6) is arranged on the side of the adjustment component facing the microfluidic chip (5), a positioning hole (12) is arranged on the microfluidic chip (5), the conical positioning pin (6) and the positioning hole (12) are arranged in a one-to-one correspondence, and the conical positioning pin (6) is inserted into the positioning hole (12) of the microfluidic chip (5) for fine-tuning the position of the microfluidic chip (5); The stepper motor (1) and the PD sensor are both electrically connected to the control unit, the PD sensor is used to sense the microchannel position of the microfluidic chip (5), and the control unit is used to receive a sensing signal from the PD sensor and control the downward movement distance of the conical positioning pin (6) according to the sensing signal.
2. The ultra-high precision adjustment device according to claim 1, characterized in that: The pushing assembly comprises a screw rod (9), the upper end of the screw rod (9) is connected to the output end of the stepping motor (1), a screw rod nut (10) is provided on the screw rod (9), and the screw rod nut (10) is connected to the adjustment assembly.
3. The ultra-high precision adjustment device according to claim 2, characterized in that: The pushing assembly further comprises a linear guide rail (2), wherein the linear guide rail (2) is mounted on the base plate (11) and the linear guide rail (2) is arranged parallel to the lead screw (9), and the lead screw nut (10) is slidably connected to the linear guide rail (2).
4. The ultra-high precision adjustment device according to claim 2, characterized in that: The adjustment assembly comprises a positioning pin bracket (7), the positioning pin bracket (7) comprises a first end, a second end and a cross plate located between the first end and the second end, the first end is used to connect the screw nut (10), the second end is slidably connected to the base plate (11), the cross plate maintains a preset spacing with the base plate (11), and the lower end surface of the cross plate is provided with two conical positioning pins (6).
5. The ultra-high precision adjustment device according to claim 4, characterized in that: Also includes: Microfluidic chip tray (4) and micro switch; The microfluidic chip tray (4) and the micro switch are both mounted on the base plate (11) and are located below the positioning pin bracket (7); the microfluidic chip tray (4) is used to carry the microfluidic chip (5) and limit the left and right movement of the microfluidic chip (5), and the micro switch is used to monitor whether the microfluidic chip (5) reaches the fine-tuning position.
6. The ultra-high precision adjustment device according to claim 4, characterized in that: It also includes a guide seat (8), which is fixed on the base plate (11). The guide seat (8) has a slide groove, and the extension direction of the slide groove is parallel to the extension direction of the screw rod (9). The end of the positioning pin bracket (7) away from the screw rod nut (10) is slidably set in the slide groove of the guide seat (8).
7. The ultra-high precision adjustment device according to claim 2, characterized in that: The left and right ends of the screw nut (10) are each slidably connected to a guide rod (13), the two guide rods (13) are arranged parallel to the screw rod (9), and the upper and lower ends of the guide rod (13) are fixed on a mounting seat, the mounting seat is fixed on the bottom plate (11), the lower end of the screw rod (9) is connected to a bearing, and the bearing is fixed on the mounting seat.
8. The ultra-high precision adjustment device according to claim 2, characterized in that: A position sensor (3) is mounted on the base plate (11), the position sensor (3) is used to detect the position of the screw nut (10), the control unit is electrically connected to the position sensor (3), the control unit is used to receive a detection signal from the position sensor (3), and control the movement range of the screw nut (10) according to the detection signal.
9. A microfluidic chip manufacturing device, characterized in that: include: The ultra-high precision adjustment device according to any one of claims 1 to 8.