Rodent self-administration device

Abstract

The utility model discloses a rodent self-administration device which comprises a box body, an injection structure and a control host, a cavity which is used for containing rodents to move and is provided with an opening in the front side is arranged in the box body, a top plate with the adjustable size is arranged at the top of the box body, and a bottom plate with the adjustable size is arranged at the bottom of the box body; the side wall of the cavity is detachably connected with the top plate, and the side wall of the cavity is detachably connected with the bottom plate. An opening is formed in the top plate; the injection structure comprises an injection pump arranged on the outer wall of the box body, a container connected with the input end of the injection pump and used for containing injection, a catheter connected with the output end of the injection pump and used for being implanted into jugular veins of rodents, and a bubble filter arranged between the output end of the injection pump and the catheter. The guide pipe penetrates through the opening of the top plate to enter the cavity; the control host is arranged on the outer wall of the box body and is used for providing power for the injection pump. Compared with the prior art, the experimental space occupied by the dosing cage is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of rodent self-medication test equipment, in particular to a rodent self-medication device. Background Art

[0002] Self-administration test is a common method in behavioral pharmacology research. Through certain controlled conditions, the animal establishes a connection between behavior and reward, and is used to evaluate whether the test substance has a rewarding effect sufficient to produce a reinforcing effect, that is, the possibility of the animal repeatedly self-administering after the first contact with the test substance, thereby simulating the situation of human drug abuse.

[0003] In the prior art, Skinner boxes are used to establish operant conditioning reflexes in rodents, such as rats, and then conduct self-administration experiments. The Skinner box is provided with a lever for the rat to press on one side of the box wall, a small box for receiving food is provided next to the lever, and a food releaser is provided outside the small hole on the box wall, in which granular food is stored. When the rat presses the lever in the box, a grain of food falls into the small box from the small hole, and the animal can eat it. In this way, the rat's operant conditioning reflex is established, and the rat's behavior pattern is strengthened.

[0004] However, in the process of implementing the self-administration experiment in the Skinner box, the training and learning cycle of rats is long, the training success rate is low, it is difficult to establish stable conditioned reflexes for rats, the behavior of rats is highly random, and it is difficult to judge the subjectivity of rats. It cannot meet the needs of long-term experiments, and thus cannot simulate the situation of human drug abuse, thereby limiting the qualitative and quantitative evaluation of the potential for drug dependence.

[0005] At the same time, with the increase in experiments on mouse self-administration, more and more laboratories will conduct self-administration experiments on rats and mice at the same time, which means that more dosing cages of different sizes and more experimental space are needed to place the dosing cages; secondly, mice are much smaller and more fragile than rats. During self-administration, slight bubbles in the injected drug solution may have no effect on rats, but they are fatal to small rodents and can easily cause venous thrombosis in mice, thus affecting the survival rate of the animals during the experiment.

[0006] Therefore, there is a need for improved self-administration devices for rodents. Utility Model Content

[0007] The technical problem to be solved by the utility model is to provide a rodent self-medication device which occupies a small space and has a higher animal survival rate in view of the above technical status.

[0008] The technical solution adopted by the utility model to solve the above technical problems is: a rodent self-medication device, characterized in that it includes:

[0009] A box body, wherein the box body has a chamber for accommodating rodents and having a front opening, the top of the box body is provided with an adjustable top plate, and the bottom of the box body is provided with an adjustable bottom plate; the side walls of the chamber and the top plate, as well as the side walls and the bottom plate, are detachably connected; and the top plate is provided with an opening;

[0010] The injection structure comprises an injection pump, a container for containing injection liquid, a catheter and a bubble filter; the injection pump is arranged on the outer wall of the box body, the container is connected to the input end of the injection pump, the catheter is connected to the output end of the injection pump and is used to be implanted into the jugular vein of a rodent, and the catheter passes through the opening of the top plate into the chamber, and the bubble filter is arranged between the output end of the injection pump and the catheter; and,

[0011] The control host is arranged on the outer wall of the box body and is used to provide power for the injection pump.

[0012] In order to make the size of the top plate adjustable, preferably, the top plate includes a first main board and a first support plate connected to the first main board; the first main board extends outward to form a first support leg; a first connecting hole is provided on the first support plate, and correspondingly, the first main board and the first support leg are both provided with a first fixing hole that can be connected to the first connecting hole through a connecting piece; the first connecting hole can be selectively connected to the first fixing hole of the first main board or the first support leg, so that the size of the top plate can be adjusted.

[0013] In order to make the size of the base plate adjustable, preferably, the base plate includes a second main board and a second support board connected to the second main board; the second main board extends outward to form a second support leg; a second connecting hole is provided on the second support plate, and correspondingly, the second main board and the second support leg are both provided with a second fixing hole that can be connected to the second connecting hole through a connecting piece; the second connecting hole can be selectively connected to the second fixing hole of the second main board or the second support leg, so that the size of the base plate can be adjusted.

[0014] Preferably, the connecting member is a bolt.

[0015] Preferably, a feed port, an infrared sensor for detecting the touch action of rodents, and an indicator light for stimulating rodents are provided on the side wall of the chamber.

[0016] Preferably, the indicator light is located on top of the infrared sensor.

[0017] In order to increase the sugar water preference and sugar water addiction experimental modules, preferably, the outer wall of the box body is provided with a sugar water conveyor connected to the feed port, and the control host provides power for the sugar water conveyor.

[0018] Preferably, the injection structure further comprises a transmission tube arranged between the output end of the injection pump and the bubble filter.

[0019] Preferably, the bottom of the chamber contains a collection chamber for collecting rodent excrement, and the top of the collection chamber has a support layer for supporting the rodent. The collection chamber is used to collect and store the excrement and urine discharged by the rodent in the chamber, which is conducive to removing the smell of the rodent when cleaning the cage box, and preventing different smells from affecting the next batch of rodent experiments.

[0020] In order to assemble the side wall and the experimental module, preferably, the side wall of the chamber includes a third main board and a third support board connected to the third main board, and the third main board and the third support board are connected through a card slot. Different modules are installed on the third support board of the side wall, and different experiments can be carried out by replacing the support board or the module.

[0021] Compared with the prior art, the utility model has the following advantages: it adopts a top plate and a bottom plate whose size can be controlled. When conducting experiments on rodents of different sizes, it is not necessary to prepare multiple self-medication devices. It is only necessary to change the size of the top plate and the bottom plate to adapt to rodents of different sizes, reduce the experimental space occupied by the medication cage and provide higher flexibility; it adopts a bubble filter arranged between the output end of the injection pump and the catheter. The bubble filter filters bubbles, thereby preventing tiny bubbles from being injected into the blood vessels and causing venous thrombosis and sudden death of rodents, especially small rodents, thereby improving the survival rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a structural schematic diagram of Example 1;

[0023] Figure 2 for Figure 1 A magnified image of point A;

[0024] Figure 3 This is a schematic diagram of the structure of another direction of Example 1;

[0025] Figure 4 is a schematic diagram of the first mainboard of Example 1;

[0026] Figure 5 is a schematic diagram of the top plate of Example 1;

[0027] Figure 6 This is a schematic diagram of the second main board of Example 1;

[0028] Figure 7 is a schematic diagram of the bottom plate of Example 1;

[0029] Figure 8 This is a schematic diagram of the structure of Example 1 suitable for rats;

[0030] Fig. 9 It is the work flow chart of Example 1;

[0031] Fig.10 This is a schematic diagram of the structure of Example 2. DETAILED DESCRIPTION

[0032] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0033] like Figure 1-9 The figure shows a preferred embodiment of the utility model. The rodent self-medication device comprises: a housing 1 , an injection structure 2 and a control host 3 .

[0034] The box body 1 has a chamber 11 with an opening at the front side for accommodating the activities of rodents, a top plate 12 of which the size can be adjusted is provided on the top of the box body 1, and a bottom plate 13 of which the size can be adjusted is provided on the bottom of the box body 1; the side wall of the chamber 11 and the top plate 12, as well as the side wall and the bottom plate 13 can be detachably connected; an opening 126 is provided on the top plate 12; the top plate 12 includes a first main board 121 and a first support plate 122 connected to the first main board 121; the first main board 121 extends outward to form a first support leg 124; a first connecting hole 123 is provided on the first support plate 122, and correspondingly, a first fixing hole 125 which can be connected to the first connecting hole 123 through a connecting piece is provided on the first main board 121 and the first support leg 124; the first connecting hole 123 can be selectively connected to the first fixing hole 125 of the first main board 121 or the first support leg 124, so that the size of the top plate 12 can be adjusted.

[0035] The bottom plate 13 includes a second main plate 131 and a second support plate 132 connected to the second main plate 131; the second main plate 131 extends outward to form a second support leg 134; the second support plate 132 is provided with a second connection hole 133, and correspondingly, the second main plate 131 and the second support leg 134 are both provided with a second fixing hole 135 that can be connected to the second connection hole 133 through a connecting member; the second connection hole 133 can be selectively connected to the second fixing hole 135 of the second main plate 131 or the second support leg 134, so that the size of the bottom plate 13 can be adjusted. In this embodiment, the connecting member is a bolt.

[0036] The side wall of the chamber 11 is provided with a feed port 14, an infrared sensor 15 for detecting the touch action of the rodent, and an indicator light 16 for stimulating the rodent; the indicator light 16 is located on the top of the infrared sensor 15. The outer wall of the box body 1 is provided with a sugar water conveyor 4 connected to the feed port 14. The bottom of the chamber 11 accommodates a collection chamber 17 for collecting rodent excrement, and the top of the collection chamber 17 is provided with a support layer 18 for supporting the rodent. The collection chamber 17 is used to collect and store the feces and urine discharged by the rodent in the chamber 11, which is conducive to removing the smell of the rodent when cleaning the cage box, and preventing different smells from affecting the next batch of rodent experiments. The injection structure 2 includes an injection pump 21 arranged on the outer wall of the box body 1, a container 25 connected to the input end of the injection pump 21 and used to contain the injection liquid, a catheter 22 connected to the output end of the injection pump 21 and used to be implanted in the jugular vein of a rodent, and a bubble filter 23 arranged between the output end of the injection pump 21 and the catheter 22, and the catheter 22 passes through the opening 126 of the top plate 12 and enters the chamber 11; the injection structure 2 also includes a transmission tube 24 arranged between the output end of the injection pump 21 and the bubble filter 23.

[0037] The control host 3 is arranged on the outer wall of the box body 1 and is used to provide power for the injection pump 21 and the sugar water conveyor 4.

[0038] like Figure 1-2 As shown, it is a rodent self-medication device suitable for mice. The first connecting hole 123 of the first support plate 122 is connected to the first fixing hole 125 of the first main board 121; the second connecting hole 133 of the second support plate 132 is connected to the second fixing hole 135 of the second main board 131.

[0039] like Figure 8 As shown, it is a rodent self-administration device suitable for rats. The first connecting hole 123 of the first support plate 122 is connected to the first fixing hole 125 of the first support leg 124; the second connecting hole 133 of the second support plate 132 is connected to the second fixing hole 135 of the second support leg 134.

[0040] Example 2

[0041] like Fig.10 As shown, it is another preferred embodiment of the utility model. Compared with embodiment 1, the side wall of the chamber 11 of this embodiment includes a third main board 191 and a third support board 192 connected to the third main board 191. The third main board 191 and the third support board 192 are connected through a slot 19.

Claims

1. A rodent self-medication device, characterized in that: include: A box (1), wherein the box (1) has a chamber (11) for accommodating rodents and having an opening at the front side, the top of the box (1) is provided with a top plate (12) whose size can be adjusted, and the bottom of the box (1) is provided with a bottom plate (13) whose size can be adjusted; the side wall of the chamber (11) and the top plate (12), as well as the side wall and the bottom plate (13) can be detachably connected; the top plate (12) is provided with an opening (126); An injection structure (2) comprises an injection pump (21), a container (25) for containing injection liquid, a catheter (22) and a bubble filter (23); the injection pump (21) is arranged on the outer wall of the housing (1), the container (25) is connected to the input end of the injection pump (21), the catheter (22) is connected to the output end of the injection pump (21) and is used for implantation into the jugular vein of a rodent, and the catheter (22) passes through an opening (126) of a top plate (12) and enters a chamber (11), and the bubble filter (23) is arranged between the output end of the injection pump (21) and the catheter (22); and, The control host (3) is arranged on the outer wall of the box body (1) and is used to provide power for the injection pump (21).

2. The rodent self-medication device according to claim 1, characterized in that: The top plate (12) comprises a first main plate (121) and a first support plate (122) connected to the first main plate (121); the first main plate (121) extends outward to form a first support leg (124); a first connecting hole (123) is provided on the first support plate (122); correspondingly, a first fixing hole (125) which can be connected to the first connecting hole (123) via a connecting piece is provided on the first main plate (121) and the first support leg (124); the first connecting hole (123) can be selectively connected to the first fixing hole (125) of the first main plate (121) or the first support leg (124), so that the size of the top plate (12) can be adjusted.

3. The rodent self-medication device according to claim 1, characterized in that: The bottom plate (13) comprises a second main plate (131) and a second support plate (132) connected to the second main plate (131); the second main plate (131) extends outward to form a second support leg (134); a second connecting hole (133) is provided on the second support plate (132); correspondingly, the second main plate (131) and the second support leg (134) are both provided with a second fixing hole (135) that can be connected to the second connecting hole (133) through a connecting piece; the second connecting hole (133) can be selectively connected to the second fixing hole (135) of the second main plate (131) or the second support leg (134), so that the size of the bottom plate (13) can be adjusted.

4. The rodent self-medication device according to claim 2 or 3, characterized in that: The connecting piece is a bolt.

5. The rodent self-medication device according to claim 1, characterized in that: The side wall of the chamber (11) is provided with a feed port (14), an infrared sensor (15) for detecting the touching action of a rodent, and an indicator light (16) for stimulating the rodent.

6. The rodent self-medication device according to claim 5, characterized in that: The indicator light (16) is located on the top of the infrared sensor (15).

7. The rodent self-administration device according to claim 5, characterized in that: The outer wall of the box body (1) is provided with a sugar water conveyor (4) which is in communication with the feed port (14), and the control host (3) provides power for the sugar water conveyor (4).

8. The rodent self-medication device according to claim 1, characterized in that: The injection structure (2) further comprises a transmission tube (24) arranged between the output end of the injection pump (21) and the bubble filter (23).

9. The rodent self-medication device according to claim 1, characterized in that: The bottom of the chamber (11) contains a collecting chamber (17) for collecting rodent excrement, and the top of the collecting chamber (17) is provided with a supporting layer (18) for supporting rodents.

10. The rodent self-medication device according to claim 1, characterized in that: The side wall of the chamber (11) comprises a third main board (191) and a third support board (192) connected to the third main board (191), and the third main board (191) and the third support board (192) are connected via a card slot (19).

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