Exosome RNA extraction kit storage device

Abstract

The utility model provides an exosome RNA extraction kit storage device, which comprises a storage box and a test tube, a placement rack is arranged in the storage box, the top of the storage box is provided with placement holes in one-to-one correspondence with placement grooves on the placement rack, the top of the storage box is provided with a plurality of parallel door-shaped racks, and the test tube is arranged on the test tube. A row of cover plates are connected to the two sides of the top of the door-shaped frame in an up-down rotating mode, the containing holes in the top of the storage box are arranged in a matrix mode and correspond to the cover plates in a one-to-one mode, an elastic pressing mechanism is arranged on the door-shaped frame, and after the bottoms of test tubes are inserted into the containing holes and make contact with the containing grooves, under the effect of the elastic pressing mechanism, the test tubes are placed in the containing grooves. The cover plate extrudes and blocks the opening part of the test tube. The test tube storage box has the advantages that the test tube storage quantity is large, the test tubes can be stably placed, liquid in the test tubes can be effectively prevented from spilling out, the test tube taking and placing resistance is small, and taking and placing operation is more convenient.

Description

Technical Field

[0001] The utility model relates to the technical field of medical auxiliary equipment, and specifically to a storage device for an exosome RNA extraction kit. Background Art

[0002] Exosomes are microcapsules that can be produced and released by almost all types of cells, including tumor cells, and contain substances such as DNA, RNA, and proteins. Numerous studies have shown that exosomes spread in body fluids such as blood, milk, and urine, and their contents, such as miRNA, can be engulfed by other cells, becoming an important medium for intercellular communication. More and more evidence shows that exosomes secreted by host cells or tumor cells are involved in tumorigenesis, growth, invasion, and metastasis. According to experimental needs, RNA in exosomes needs to be extracted and stored, but the existing storage device has poor stability. When the storage device is moved, the exosome RNA reagent will shake, causing the exosome RNA reagent inside to spill out and cause waste.

[0003] The utility model with publication number CN214361412U proposes a storage device for an exosome RNA extraction kit. By setting up this device, the stability of the exosome RNA reagent can be improved, thereby avoiding shaking when moving, avoiding waste of the exosome RNA reagent, and improving practicality; it includes a box, a support frame, a controller, multiple groups of test tubes, multiple groups of insertion rods, multiple groups of push blocks and an operation panel, a storage cavity is arranged inside the box, the support frame is installed at the lower part of the storage cavity, the controller is installed at the bottom end of the storage cavity, annular grooves are arranged on the outer side of the lower part of the multiple groups of test tubes, the multiple groups of insertion rods are respectively connected with the multiple groups of annular grooves, the support frame is arranged inside the box, multiple groups of connection devices are arranged in the box, multiple groups of push blocks are installed at the outer end of the connection, the multiple groups of push blocks are located on the front side of the box, the operation panel is installed at the front end of the box, and the operation panel is electrically connected to the controller.

[0004] However, the above-mentioned prior art still has shortcomings when used: 1. An annular groove needs to be processed on the outside of the test tube, which reduces the versatility of the test tube, and the push block structure provided for releasing the test tube leads to a significant reduction in the number of test tubes placed in the storage device, that is, one test tube corresponds to one push block, and when there are multiple test tubes arranged in a matrix, it is difficult for the push block to correspond to the test tube one by one; 2. There is a lack of a sealing structure for the mouth of the test tube, so that the reagent in the test tube is in an exposed state and is easily contaminated by dust.

[0005] To this end, the utility model provides a storage device for an exosome RNA extraction kit. Utility Model Content

[0006] In view of the shortcomings of the prior art, the purpose of the utility model is to provide an exosome RNA extraction kit storage device to solve the problems raised in the above-mentioned background technology. The utility model has the advantages of a large test tube storage capacity, which can effectively prevent the liquid inside the test tube from spilling while improving the stable placement of the test tube. In addition, the resistance to taking and placing the test tube is small, and the taking and placing operation is more convenient.

[0007] In order to achieve the above-mentioned purpose, the utility model is realized through the following technical scheme: an exosome RNA extraction kit storage device, comprising a storage box and a test tube, a placement rack is arranged in the storage box, and a placement hole corresponding to the placement slot on the placement rack is opened on the top of the storage box, and a plurality of parallel door-shaped frames are arranged on the top of the storage box, and a row of cover plates are connected to the two sides of the top of the door-shaped frame for rotation up and down. The placement holes on the top of the storage box are arranged in a matrix and correspond to the cover plates one by one. An elastic clamping mechanism is arranged on the door-shaped frame. After the bottom of the test tube is inserted into the placement hole and then contacts the placement slot, the cover plate squeezes and seals the mouth of the test tube under the action of the elastic clamping mechanism.

[0008] Furthermore, a horizontal axis is fixedly connected to both sides of the top crossbeam of the portal frame, an arm plate is welded to the outer peripheral wall of the cover plate, a gear sleeved on the horizontal axis is welded to the free end of the arm plate, the gear is sleeved on the horizontal axis and the two are rotatably connected, and the elastic clamping mechanism includes a tooth plate, which is slidably connected to the crossbeam up and down and meshes with the gears on both sides.

[0009] Furthermore, teeth meshing with gears are provided on both sides of the tooth plate, a U-shaped groove is provided on the top of the tooth plate, the U-shaped groove and the cross beam are slidably matched, a limit plate located below the tooth plate is welded in the door frame, the elastic clamping mechanism includes a connecting spring, and the bottom of the tooth plate is connected to the limit plate through the connecting spring.

[0010] Furthermore, a pressing plate is welded on the top of the tooth plate, a limiting rod is welded through the pressing plate, a magnet is bonded to the bottom of the limiting rod, and an iron block is welded on the top of the beam.

[0011] Furthermore, a silicone pad is bonded to the lower end surface of the cover plate, and the lower end surface of the silicone pad is a spherical surface.

[0012] Furthermore, a buffer spring is provided at the bottom of the placement groove, and a pad is welded on the top of the buffer spring.

[0013] Furthermore, a shock-absorbing rubber pad is bonded to the upper end surface of the pad.

[0014] The beneficial effects of the utility model are as follows:

[0015] 1. The utility model arranges a door frame on the top of the storage box, and then arranges up and down swinging covers on both sides of the door frame. When the test tube is inserted into the top of the storage box, the cover plate is controlled to swing down to cover the top of the test tube. An elastic pressing mechanism is arranged on the door frame so that the test tube is squeezed into the storage box. Compared with the prior art, this structure for limiting the upper position of the test tube has the advantage of being able to accommodate more test tubes.

[0016] 2. The utility model provides a silicone pad at the lower part of the cover plate. When the cover plate covers the mouth of the test tube, the silicone pad can seal the mouth of the test tube, which can effectively prevent the problem of reagent spilling out of the mouth of the test tube.

[0017] 3. The utility model provides an elastic clamping mechanism to facilitate the simultaneous upward and downward movement of all cover plates on the door frame, thereby reducing the resistance to taking and placing the test tubes and making the position limiting operation of the test tubes more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the structure of the door frame, test tubes and cover plate of a storage device for an exosome RNA extraction kit of the utility model;

[0019] Figure 2 for Figure 1 The enlarged schematic diagram of the part "a" in the middle;

[0020] Figure 3 This is a cross-sectional view of a storage device for an exosome RNA extraction kit of the utility model;

[0021] In the figure: 1. storage box; 11. placement hole; 2. placement rack; 21. placement slot; 3. door-type rack; 31. crossbeam; 311. cross axis; 312. iron block; 32. limit plate; 4. cover plate; 41. arm plate; 411. gear; 5. test tube; 6. elastic clamping mechanism; 61. tooth plate; 611. pressing plate; 6111. limit rod; 612. U-shaped slot; 62. connecting spring; 7. magnet; 8. silicone pad; 9. buffer spring; 91. pad; 911. shock-absorbing rubber pad. DETAILED DESCRIPTION

[0022] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0023] See also Figures 1 to 3 The utility model provides a technical solution: a storage device for an exosome RNA extraction kit, comprising a storage box 1 and a test tube 5. A placement rack 2 is provided in the storage box 1. A placement hole 11 corresponding to a placement slot 21 on the placement rack 2 is opened on the top of the storage box 1. When placing the test tube 5, the test tube 5 passes through the placement hole 11 and is inserted into the placement slot 21.

[0024] In the present technical solution, a plurality of parallel door frames 3 are arranged on the top of the storage box 1, and a row of cover plates 4 are rotatably connected to the top and bottom of the two sides of the door frame 3. The specific implementation structure is that a horizontal axis 311 is fixedly connected to the two sides of the top cross beam 31 of the door frame 3, an arm plate 41 is welded to the outer peripheral wall of the cover plate 4, and a gear 411 sleeved on the horizontal axis 311 is welded to the free end of the arm plate 41, and the gear 411 is sleeved on the horizontal axis 311 and the two are rotatably connected, and when the gear 411 is controlled to rotate, the cover plate 4 can be controlled to swing.

[0025] The placement holes 11 on the top of the storage box 1 are arranged in a matrix and correspond one to one with the cover plate 4. One cover plate 4 corresponds to one test tube 5. When the cover plate 4 is lowered, it can press the mouth of the test tube 5. An elastic clamping mechanism 6 is provided on the door frame 3. After the bottom of the test tube 5 is inserted into the placement hole 11 and then contacts the placement groove 21, the cover plate 4 squeezes and blocks the mouth of the test tube 5 under the action of the elastic clamping mechanism 6. At this time, the test tube 5 will be stably fixed on the storage box 1, and one door frame 3 corresponds to two rows of test tubes 5. Several door frames 3 correspond to test tubes 5 arranged in a matrix, which greatly increases the number of test tubes 5 stored.

[0026] The elastic clamping mechanism 6 includes a tooth plate 61, which is slidably connected to the cross beam 31 and meshed with the gears 411 on both sides. When the tooth plate 61 is controlled to move up and down, it can drive all the cover plates 4 on the current door frame 3 to swing up and down, wherein teeth meshing with the gears 411 are provided on both sides of the tooth plate 61, and a U-shaped groove 612 is provided on the top of the tooth plate 61, and the U-shaped groove 612 and the cross beam 31 are slidably matched.

[0027] Furthermore, a limit plate 32 located below the tooth plate 61 is welded in the door frame 3, and the elastic clamping mechanism 6 includes a connecting spring 62. The bottom of the tooth plate 61 is connected to the limit plate 32 through the connecting spring 62. The connecting spring 62 acts as an elastic upward thrust on the tooth plate 61. When the tooth plate 61 moves upward, it will drive the cover plate 4 to swing downward through the gear 411.

[0028] In this embodiment, a pressing plate 611 is welded to the top of the tooth plate 61, a limiting rod 6111 is welded through the pressing plate 611, a magnet 7 is bonded to the bottom of the limiting rod 6111, and an iron block 312 is welded to the top of the beam 31. When the pressing plate 611 is pushed downward manually, the tooth plate 61 moves downward, and when the magnet 7 and the iron block 312 are adsorbed, the cover plate 4 is in an open state, which is convenient for taking and placing the test tube 5.

[0029] In this embodiment, a silicone pad 8 is bonded to the lower end surface of the cover plate 4. The lower end surface of the silicone pad 8 is a spherical surface. The silicone pad 8 can seal the mouth of the test tube 5 to prevent the reagent from spilling.

[0030] In this embodiment, a buffer spring 9 is provided at the bottom of the placement groove 21, and a pad 91 is welded on the top of the buffer spring 9, wherein a shock-absorbing rubber pad 911 is bonded to the upper end surface of the pad 91. After the test tube 5 is inserted into the placement groove 21, the shock-absorbing rubber pad 911 and the buffer spring 9 can buffer the test tube 5.

[0031] Working principle: when it is necessary to place the test tube 5, the pressing plate 611 is pushed downward manually, the tooth plate 61 moves downward, the connecting spring 62 is compressed, the gear 411 rotates to drive the cover plate 4 to swing upward, the bottom of the test tube 5 is passed through the placement hole 11 and inserted into the placement slot 21, and then the limiting rod 6111 is manually pulled up, the magnet 7 is separated from the iron block 312, the connecting spring 62 moves upward to push the tooth plate 61 upward, the gear 411 rotates in the opposite direction to drive the cover plate 4 to swing downward, the silicone pad 8 at the bottom of the cover plate 4 squeezes and seals the mouth of the test tube 5, and the test tube 5 is in a stable placement and sealing state.

[0032] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A storage device for an exosome RNA extraction kit, comprising a storage box (1) and a test tube (5), wherein a storage rack (2) is provided in the storage box (1), and a placement hole (11) corresponding to a placement slot (21) on the placement rack (2) is provided on the top of the storage box (1), characterized in that: The top of the storage box (1) is provided with a plurality of parallel door-shaped frames (3), and a row of cover plates (4) are connected to the two sides of the top of the door-shaped frames (3) in a rotatable manner. The placement holes (11) on the top of the storage box (1) are arranged in a matrix and correspond one to one with the cover plates (4). The door-shaped frames (3) are provided with an elastic clamping mechanism (6). After the bottom of the test tube (5) is inserted into the placement hole (11) and then contacts the placement groove (21), the cover plate (4) squeezes and seals the mouth of the test tube (5) under the action of the elastic clamping mechanism (6).

2. The storage device for an exosome RNA extraction kit according to claim 1, characterized in that: A transverse shaft (311) is fixedly connected to both sides of the top transverse beam (31) of the portal frame (3); an arm plate (41) is welded to the outer peripheral wall of the cover plate (4); a gear (411) sleeved on the transverse shaft (311) is welded to the free end of the arm plate (41); the gear (411) is sleeved on the transverse shaft (311) and the two are rotatably connected; the elastic clamping mechanism (6) comprises a tooth plate (61); the tooth plate (61) is slidably connected to the transverse beam (31) up and down and meshes with the gears (411) on both sides.

3. The storage device for an exosome RNA extraction kit according to claim 2, characterized in that: The tooth plate (61) is provided with teeth meshing with the gear (411) on both sides, the top of the tooth plate (61) is provided with a U-shaped groove (612), the U-shaped groove (612) and the cross beam (31) are slidably matched, a limit plate (32) located below the tooth plate (61) is welded in the door frame (3), the elastic clamping mechanism (6) includes a connecting spring (62), and the bottom of the tooth plate (61) is connected to the limit plate (32) via the connecting spring (62).

4. The storage device for an exosome RNA extraction kit according to claim 3, characterized in that: A pressing plate (611) is welded to the top of the tooth plate (61), a limiting rod (6111) is welded through the pressing plate (611), a magnet (7) is bonded to the bottom of the limiting rod (6111), and an iron block (312) is welded to the top of the crossbeam (31).

5. The storage device for an exosome RNA extraction kit according to claim 1, characterized in that: A silicone pad (8) is bonded to the lower end surface of the cover plate (4), and the lower end surface of the silicone pad (8) is a spherical surface.

6. The storage device for an exosome RNA extraction kit according to claim 1, characterized in that: A buffer spring (9) is arranged at the bottom of the placement groove (21), and a pad (91) is welded to the top of the buffer spring (9).

7. The storage device for an exosome RNA extraction kit according to claim 6, characterized in that: A shock-absorbing rubber pad (911) is bonded to the upper end surface of the pad (91).

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