Random control experiment system for transcranial magnetic stimulation

Abstract

The utility model discloses a transcranial magnetic stimulation random control experiment system, which comprises a transcranial magnetic stimulator and an experiment manager, the transcranial magnetic stimulator is provided with a main control module, a card reader and a stimulation coil, and the experiment manager is provided with an experiment management module and a read-write card module. The main control module is respectively in communication connection with the card reader, the stimulation coil and the experiment management module, the experiment management module is in communication connection with the read-write card module, and compared with the prior art, the transcranial magnetic double-blind contrast stimulation experiment system has the advantage of being scientific and reliable. By using the system, subjective factor interference in an experiment can be reduced, and the accuracy and reliability of an experiment result are improved. Meanwhile, the system has high flexibility, design and distribution of experiment samples and stimulation samples can be carried out according to needs, and different experiment requirements are met. Therefore, the technical scheme has great application value and market potential.

Description

Technical Field

[0001] The utility model relates to the technical field of transcranial magnetic stimulation experiments, in particular to a randomized controlled experiment system for transcranial magnetic stimulation. Background Art

[0002] Transcranial Magnetic Stimulation (TMS) is a magnetic stimulation technology that uses pulsed magnetic fields to act on the central nervous system (mainly the brain) to change the membrane potential of cortical nerve cells, generate induced currents, affect brain metabolism and neural electrical activity, and thus cause a series of physiological and biochemical reactions. Due to its advantages such as painlessness, non-damage, and no radiation, it has gained increasing recognition in the fields of cognitive neuroscience, clinical neuropsychiatric diseases, and rehabilitation. As an emerging treatment for mental and neurological diseases, although the therapeutic effect has been gradually recognized, there are still people, including medical practitioners and patients, who are skeptical about its effectiveness. Controlled experimental methods can be used to prevent research results from being affected by the placebo effect or observer bias.

[0003] There are three commonly used control experiment methods:

[0004] (i) The stimulation surface of the ordinary coil was placed at 90° to the patient: In the control group, the stimulation coil and the stimulation site were placed at 90°, so that the magnetic field could not effectively act on the stimulation area through the spatial position relationship.

[0005] (ii) Single-blind stimulation coil: A thickened stimulation coil is used with the internal wire coil close to the stimulation surface of the coil. The experimental group uses the stimulation surface for stimulation, and the control group uses the reverse side for stimulation. By taking advantage of the fact that the magnetic field size is inversely proportional to the cube of the distance, the magnetic field on the reverse side of the stimulation coil has decayed to about 10% of the stimulation surface, thereby achieving the effect of no effective stimulation.

[0006] (III) Double-sided output coil based on physical switch switching: A thickened double-sided stimulation coil with wire coils on both sides is used. The physical switch is used to control the thyristor module in the transcranial magnetic stimulator to output electrical pulses to different wire coils of the coil (the experimental group outputs to the wire coil on the stimulation surface, and the control group outputs to the wire coil above the stimulation surface).

[0007] It can be understood that although the operation of scheme 1 is simple and does not require special technical support, the experimental designer, equipment operator and subject can intuitively know whether effective stimulation has been carried out, so the placebo effect and observer preference cannot be ruled out; schemes 2 and 3 can basically achieve single-blind control effects and exclude placebo effects, but the operator needs to reverse the coil or switch the switch in advance according to the experimental design, and the influence of the observer preference effect cannot be ruled out. Furthermore, even if double-blind is achieved, if the data collectors and verifiers are not blinded, during the data collection and transfer process, it cannot be ruled out that they intentionally exclude a group of bad data. Similarly, if the statistical analyst is not blinded, it cannot be ruled out that they choose analysis methods that are conducive to transcranial magnetic stimulation out of interest or position, and exclude some data that are not conducive to the promotion of transcranial magnetic stimulation, thereby losing the authenticity and credibility of the conclusion. Therefore, a transcranial magnetic control stimulation experimental method and system are needed to solve the problems existing in the prior art and improve the objectivity and accuracy of the experimental results. Utility Model Content

[0008] The purpose of the utility model is to address the technical problems existing in the background technology and to propose a randomized controlled experiment system for transcranial magnetic stimulation, including a transcranial magnetic stimulator and an experiment manager. The transcranial magnetic stimulator is provided with a main control module, a card reader and a stimulation coil. The experiment manager is provided with an experiment management module and a card reader / writer module. The main control module is respectively communicated with the card reader, the stimulation coil and the experiment management module, and the experiment manager is communicated with the card reader / writer module.

[0009] Furthermore, the transcranial magnetic stimulator also includes a pulse generating module and a thyristor module. The thyristor module is respectively connected to the main control module and the stimulation coil for communication between the main control module and the stimulation coil. The pulse generating module is respectively connected to the stimulation coil and the thyristor module for communication.

[0010] Furthermore, the pulse generating module includes a high-voltage charging board and an energy storage capacitor. The high-voltage charging board is used to boost the voltage of the mains electricity, and the energy storage capacitor is used to store the boosted electrical energy to power the stimulation coil.

[0011] Further, the thyristor module includes a stimulation trigger board, a true stimulation forward thyristor, a true stimulation reverse thyristor, a pseudo stimulation forward thyristor and a pseudo stimulation reverse thyristor;

[0012] The input end of the stimulation trigger board is connected to the main control module, and the output end is respectively connected to the input end of the true stimulation forward thyristor, the input end of the true stimulation reverse thyristor, the input end of the pseudo stimulation forward thyristor and the input end of the pseudo stimulation reverse thyristor; the output end of the true stimulation forward thyristor, the output end of the true stimulation reverse thyristor, the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor are respectively connected to the stimulation coil.

[0013] Furthermore, the stimulation coil includes a true stimulation coil and a pseudo stimulation coil. The true stimulation coil is connected to the output end of the true stimulation forward thyristor and the output end of the true stimulation reverse thyristor, and the pseudo stimulation coil is connected to the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor.

[0014] Furthermore, the experiment management module includes a data processing unit and a random allocation unit. The data processing unit is used to process and analyze the experimental data, and the random allocation unit is used to control the card reader / writer module to randomly write true or false stimulus information to the card.

[0015] Furthermore, the experiment management module includes an encryption unit and a mode selection unit. The encryption unit is used to encrypt and decrypt the card, and the mode selection unit is used to set the experiment mode.

[0016] Furthermore, the experiment management module includes a sample stratification unit, which is used to perform stratified screening on the experimental samples.

[0017] Compared with the prior art, the utility model has the following beneficial technical effects:

[0018] 1. The utility model provides a transcranial magnetic double-blind, triple-blind control stimulation experiment method and system, the system includes a pulse generation module, a thyristor module, a main control module, a stimulation coil, an NFC card reader module, an experiment management module, etc. Through this system, a transcranial magnetic double-blind, triple-blind control stimulation experiment can be carried out, and the random allocation of true and false stimulation can be achieved.

[0019] 2. This system writes the authenticity information into the NFC card through the authenticity random writing algorithm, and reads the card information through the card recognition module, thereby realizing the control of authenticity and fake stimulation. This stimulation control method has high accuracy and reliability, which can ensure the scientificity and credibility of the experiment.

[0020] 3. Unblinding through the experimental management module, i.e., software, can effectively protect the objectivity and fairness of the experimental results. In a double-blind experiment, neither the equipment operator nor the test subject can know whether the stimulation is real stimulation. In a triple-blind experiment, the experimental designer (data collector and verifier) ​​can be blinded to eliminate the possibility of bad experimental results being artificially eliminated during data collection and transfer. While ensuring the flexibility of the experimental design, it avoids the influence of subjective factors on the experimental results.

[0021] 4. This technical solution can also design experiments based on the pre-set experimental sample size and the ratio of stimulation samples to control samples, and perform statistical analysis on the therapeutic effects of the experimental group and the control group after stimulation. This statistical analysis can provide a scientific basis for evaluating the impact of stimulation on the therapeutic effect.

[0022] In summary, the utility model is superior to the prior art in that it provides a scientific and reliable transcranial magnetic double-blind control stimulation experimental system. By using this system, the interference of subjective factors in the experiment can be reduced, and the accuracy and reliability of the experimental results can be improved. At the same time, the system has high flexibility and can design and distribute experimental samples and stimulation samples as needed to meet different experimental needs. Therefore, this technical solution has great application value and market potential. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a structural block diagram of the utility model system;

[0024] Figure 2 It is the structural diagram of the thyristor module;

[0025] Figure 3 It is a flow chart of the system of the utility model;

[0026] Figure 4 for Figure 3 A partial enlarged view of a part;

[0027] Figure 5 for Figure 3 A partial enlarged view of a part;

[0028] Figure 6 It is a layered example of the test sample of the utility model;

[0029] Figure 7 The single-layer card writing process of the utility model;

[0030] Figure 8 Figure 7 A partial enlarged view of a part;

[0031] Fig. 9 Figure 7 A partial enlarged view of the part. DETAILED DESCRIPTION

[0032] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments can be combined with each other.

[0033] In the description of the present utility model, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or component referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model. In addition, the terms "first", "second", etc. are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first", "second", etc. may explicitly or implicitly include one or more features. In the description of the present utility model, unless otherwise specified, "multiple" means two or more.

[0034] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or a specific connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood by specific circumstances.

[0035] The specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0036] Embodiment 1:

[0037] like Figure 1-Figure 9 As shown, this embodiment proposes a randomized controlled experiment system for transcranial magnetic stimulation, including a transcranial magnetic stimulator and an experiment manager. The transcranial magnetic stimulator is provided with a main control module, a card reader and a stimulation coil. The experiment manager is provided with an experiment management module and a card reader / writer module. The main control module is respectively communicated with the card reader, the stimulation coil and the experiment management module, and the experiment management module is communicated with the card reader / writer module.

[0038] It can be understood that in this embodiment, the card reader is used to read the NFC card, and the NFC card stores true stimulation information or false stimulation information. The main control module controls the stimulation coil to perform "true transcranial magnetic stimulation" or "false transcranial magnetic stimulation" on the subject according to the true stimulation information or false stimulation information received by the card reader. The true transcranial magnetic stimulation group serves as the experimental group, and the false transcranial magnetic stimulation group serves as the control group. Furthermore, the experiment management module is used to set the number of test samples, the ratio of the experimental group and the control group, and control the card reader / writer module to randomly write true or false stimulation information to the NFC card, or read the true or false stimulation information in the NFC card.

[0039] Through the above settings, the experiment designer can set the number of test samples and the ratio of the experimental group and the control group in advance through the experiment management module. The experiment management module controls the card reader and writer module to randomly write true and false stimulation information to each NFC card according to the ratio of the experimental group and the control group. During the detection, the above NFC cards will be randomly distributed to each test subject by the equipment operator. During the test, the authenticity information in the NFC card can be transmitted to the main control module through the card reader. The main control module then controls the stimulation coil according to the received information to perform true and false transcranial magnetic stimulation on the test subject. During the first stimulation, the equipment operator needs to create a file for the test subject and fill in the card number. After the stimulation is completed, the experiment designer can import the stimulation record into the experiment management module through the main control module to perform statistical analysis on the stimulation record and form an experimental result report.

[0040] Furthermore, in this embodiment, the transcranial magnetic stimulator also includes a pulse generating module and a thyristor module. The thyristor module is respectively communicated with the main control module and the stimulation coil to realize the communication connection between the main control module and the stimulation coil. The pulse generating module is respectively communicated with the stimulation coil and the thyristor module.

[0041] Through the above settings, the main control module can read the authenticity information from the NFC card, send a trigger signal to the thyristor module according to the stimulation scheme parameters preset by the experimental designer, and control the electromagnetic pulse output of the entire system.

[0042] Specifically, in the present embodiment, the pulse generation module is composed of a high-voltage charging plate and an energy storage capacitor, and its function is to store the mains voltage after boosting it, and release energy to the stimulation coil during stimulation. The thyristor module includes a stimulation trigger plate, a true stimulation forward thyristor, a true stimulation reverse thyristor, a pseudo stimulation forward thyristor, a pseudo stimulation reverse thyristor and two absorption circuits. The input end of the stimulation trigger plate is connected to the main control module, and the output end is respectively connected to the input end of the true stimulation forward thyristor, the input end of the true stimulation reverse thyristor, and the pseudo stimulation forward thyristor. The input end of the true stimulation forward thyristor is connected to the input end of the pseudo stimulation reverse thyristor, the output end of the true stimulation reverse thyristor, the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor are respectively connected to the stimulation coil, the stimulation coil includes a true stimulation wire disk and a pseudo stimulation wire disk, the true stimulation wire disk is connected to the output end of the true stimulation forward thyristor and the output end of the true stimulation reverse thyristor, the pseudo stimulation wire disk is connected to the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor.

[0043] Through the above settings, when the stimulation trigger board receives the trigger signal from the main control module, it will output two trigger signals to the corresponding thyristors. The width of the forward thyristor is a trigger signal of 40us and an amplitude of 12V, and the width of the reverse thyristor is a trigger signal of 460us and an amplitude of 12V, thereby controlling the energy storage capacitor to discharge to different coils of the stimulation coil to achieve the purpose of true and false stimulation.

[0044] Furthermore, in the present embodiment, the experiment management module includes a data processing unit, an encryption unit, a random allocation unit and a mode selection unit. The data processing unit is used to perform data processing and analysis on the stimulation records imported into the experiment management module to form an experiment result report. The random allocation unit is used to control the card reader / writer module to realize random writing of true and false stimulation information to the card. The encryption unit is used to encrypt and decrypt the true and false reading authority of the card. The mode selection unit is used to set the experiment mode. Specifically, the experiment mode includes a single-blind mode, a double-blind mode and a triple-blind mode. The single-blind mode means that the "true and false stimulation" is hidden from the test subject and disclosed to the equipment operator and the experiment designer. The double-blind mode means that the "true and false stimulation" is hidden from the test subject and the equipment operator and disclosed to the experiment designer. The triple-blind mode means that the "true and false stimulation" is hidden from the test subject and the equipment operator and disclosed to the experiment designer.

[0045] It can be understood that if the experimental mode is a single-blind mode, there is no need to encrypt the authenticity reading authority of the card through the encryption unit. Through the above settings, the device operator and the experimental designer can always know the authenticity information stored in the current NFC card;

[0046] If the experimental mode is a double-blind mode or a triple-blind mode, the authenticity reading permission of the card needs to be encrypted by the encryption unit after writing to the NFC card. Furthermore, if the experimental mode is a double-blind mode, after the stimulation record is imported, the encryption unit unlocks the authenticity reading permission of the card and forms an experimental result report. Through the above settings, before the experimental result report is formed, only the experimental designer can know the authenticity information stored in the NFC card corresponding to each stimulation record data;

[0047] If the experimental mode is the triple-blind mode, then after the experimental result report is formed, the encryption unit unlocks the card authenticity reading permission. Through the above settings, before the experimental result report is formed, the test subject, the equipment operator and the experimental designer cannot know the authenticity information stored in the NFC card corresponding to each stimulation record data.

[0048] Furthermore, in this embodiment, the experiment management module also includes a sample stratification unit, which is used to perform stratified screening on the experimental samples. Through the above settings, before random card writing, the test samples can also be stratified by the stratification unit. Specifically, the stratification unit can divide the test samples into two groups according to gender, which are recorded as the first-layer grouping; and then the first-layer grouping is divided into several second-layer groups according to age. After the grouping is completed, the first-layer grouping or the second-layer grouping is randomly written into the corresponding card in batches according to the set experimental group and control group ratio. Through the above settings, the utility model can also perform comparative analysis on test samples of different genders and different age stages separately or simultaneously.

[0049] Embodiment 2:

[0050] like Figure 1-Figure 9 As shown, this embodiment proposes a randomized controlled experiment method for transcranial magnetic stimulation, which is applied to the control experiment system of embodiment 1. The control experiment method includes the following steps:

[0051] S1: The experiment designer sets the total number of test samples, the ratio of the experimental group to the control group, and the experimental mode according to the experimental management module. The experimental modes include single-blind mode, double-blind mode and triple-blind mode;

[0052] S2: The experiment management module randomly writes the real stimulus information and the pseudo stimulus information into the card through the card reading and writing module according to the total number of test samples and the ratio of the experimental group to the control group;

[0053] S3: If the experimental mode is a double-blind mode or a triple-blind mode, the authenticity reading permission of the card is locked through the experimental management module;

[0054] S4: The device operator randomly distributes the cards, and the main control module reads the authenticity information of the distributed cards through the card reader to control the stimulation coil to achieve authenticity stimulation to the test subject;

[0055] S5: After the stimulation is completed, the experimental designer imports the stimulation record into the experimental management module to perform statistical analysis on the stimulation record and form an experimental result report;

[0056] S6: If the experimental mode is a double-blind mode, then after the stimulation record is imported, the experimental management module unlocks the card authenticity reading permission and forms an experimental result report. If the experimental mode is a triple-blind mode, then after the experimental result report is formed, the experimental management module unlocks the card authenticity reading permission.

[0057] Furthermore, in this embodiment, step S2 also includes the following steps:

[0058] S21: Determine whether N*K1 / (K1:K2) and N*K2 / (K1:K2) are positive integers. If the determination result is "false", reallocate the ratio of K1:K2 until the determination result is "true".

[0059] S22: If the experimental mode is a single-blind mode, the true stimulus information is put into N*K1 / (K1:K2) true cards, and the false stimulus information is put into N*K2 / (K1:K2) false cards;

[0060] S23: If the experimental mode is a double-blind mode or a triple-blind mode, then initialize the real card serial number set, where the number of real cards M = N*K1 / (K1:K2);

[0061] S24: randomly draw a number from the sequence number [0-N-1], and determine whether the number is already in the set of true cards. If it is determined to be "true", repeat the above random number drawing step; if it is determined to be "false", add the sequence number to the set of true card sequence numbers;

[0062] S25: Determine whether the data volume of the genuine card serial number set is less than M. If it is determined to be "true", repeat the above-mentioned random number drawing step of the genuine card serial number set until the judgment of this step is "false";

[0063] S26: Write cards in order from [0-N-1], if the current sequence number falls into the true card set, write true stimulation information to the card corresponding to the sequence number, otherwise write false stimulation information;

[0064] S27: Determine whether the serial number of the card currently being written is N-1. If it is determined to be "true", the writing is terminated. If it is determined to be "false", the above-mentioned steps of sequentially writing the card are repeated.

[0065] Furthermore, preferably, between step S1 and step S2, the following steps are also included:

[0066] The management module performs sample stratification on the test samples;

[0067] The test samples were divided into two groups according to gender, which was recorded as the first-level grouping;

[0068] The first-level groups are divided into several second-level groups according to age.

[0069] Correspondingly, step S2 is optimized as follows: the experiment management module randomly writes the true stimulation information and the pseudo stimulation information into corresponding cards in batches according to the set ratio of the experimental group to the control group according to the plurality of second-level groups.

[0070] Furthermore, step S1 further includes the following steps:

[0071] S11: Create a dedicated account and password in the experiment management module;

[0072] S12: The experiment designer logs into the system with the account and password, creates an experimental project, and enters the total sample size, the sample ratio of the experimental group and the control group, the start and end time of the project, and selects the experimental mode.

[0073] It can be understood that, in combination with Embodiment 1 and Embodiment 2, the present utility model has the following beneficial effects:

[0074] 1. The utility model provides a transcranial magnetic double-blind, triple-blind control stimulation experiment method and system, the system includes a pulse generation module, a thyristor module, a main control module, a stimulation coil, an NFC card reader module, an experiment management module, etc. Through this system, a transcranial magnetic double-blind, triple-blind control stimulation experiment can be carried out, and the random allocation of true and false stimulation can be achieved.

[0075] 2. This system writes the authenticity information into the NFC card through the authenticity random writing algorithm, and reads the card information through the card recognition module, thereby realizing the control of authenticity and fake stimulation. This stimulation control method has high accuracy and reliability, which can ensure the scientificity and credibility of the experiment.

[0076] 3. Unblinding through the experimental management module, i.e., software, can effectively protect the objectivity and fairness of the experimental results. In a double-blind experiment, neither the equipment operator nor the test subject can know whether the stimulation is real stimulation. In a triple-blind experiment, the experimental designer (data collector and verifier) ​​can be blinded to eliminate the possibility of bad experimental results being artificially eliminated during data collection and transfer. While ensuring the flexibility of the experimental design, it avoids the influence of subjective factors on the experimental results.

[0077] 4. This technical solution can also design experiments based on the pre-set experimental sample size and the ratio of stimulation samples to control samples, and perform statistical analysis on the therapeutic effects of the experimental group and the control group after stimulation. This statistical analysis can provide a scientific basis for evaluating the impact of stimulation on the therapeutic effect.

[0078] In summary, the utility model is superior to the prior art in that it provides a scientific and reliable transcranial magnetic double-blind control stimulation experimental system. By using this system, the interference of subjective factors in the experiment can be reduced, and the accuracy and reliability of the experimental results can be improved. At the same time, the system has high flexibility and can design and distribute experimental samples and stimulation samples as needed to meet different experimental needs. Therefore, this technical solution has great application value and market potential.

[0079] The above are one or more implementation methods provided in combination with specific content, and it is not intended that the specific implementation of the utility model is limited to these descriptions. Any method, structure, etc. similar to or identical to the method, structure, etc. of the utility model, or any technical deduction or replacement based on the concept of the utility model, shall be deemed to be within the protection scope of the utility model.

Claims

1. A randomized controlled trial system for transcranial magnetic stimulation, characterized in that: It includes a transcranial magnetic stimulator and an experiment manager. The transcranial magnetic stimulator is provided with a main control module, a card reader and a stimulation coil. The experiment manager is provided with an experiment management module and a card reader / writer module. The main control module is respectively communicated with the card reader, the stimulation coil and the experiment management module, and the experiment manager is communicated with the card reader / writer module.

2. A randomized controlled trial system for transcranial magnetic stimulation according to claim 1, characterized in that: The transcranial magnetic stimulator also includes a pulse generating module and a thyristor module. The thyristor module is respectively connected to the main control module and the stimulation coil for communication between the main control module and the stimulation coil. The pulse generating module is respectively connected to the stimulation coil and the thyristor module for communication.

3. A randomized controlled trial system for transcranial magnetic stimulation according to claim 2, characterized in that: The pulse generating module comprises a high-voltage charging board and an energy storage capacitor. The high-voltage charging board is used to boost the voltage of the mains electricity, and the energy storage capacitor is used to store the boosted electrical energy to power the stimulation coil.

4. A randomized controlled trial system for transcranial magnetic stimulation according to claim 3, characterized in that: The thyristor module includes a stimulation trigger plate, a true stimulation forward thyristor, a true stimulation reverse thyristor, a pseudo stimulation forward thyristor and a pseudo stimulation reverse thyristor; The input end of the stimulation trigger board is connected to the main control module, and the output end is respectively connected to the input end of the true stimulation forward thyristor, the input end of the true stimulation reverse thyristor, the input end of the pseudo stimulation forward thyristor and the input end of the pseudo stimulation reverse thyristor; the output end of the true stimulation forward thyristor, the output end of the true stimulation reverse thyristor, the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor are respectively connected to the stimulation coil.

5. A randomized controlled trial system for transcranial magnetic stimulation according to claim 4, characterized in that: The stimulation coil includes a true stimulation coil and a pseudo stimulation coil. The true stimulation coil is connected to the output end of the true stimulation forward thyristor and the output end of the true stimulation reverse thyristor, and the pseudo stimulation coil is connected to the output end of the pseudo stimulation forward thyristor and the output end of the pseudo stimulation reverse thyristor.

6. A randomized controlled trial system for transcranial magnetic stimulation according to claim 1, characterized in that: The experiment management module includes a data processing unit and a random allocation unit. The data processing unit is used to process and analyze the experimental data, and the random allocation unit is used to control the card reading and writing module to randomly write true and false stimulus information to the card.

7. A randomized controlled trial system for transcranial magnetic stimulation according to claim 1, characterized in that: The experiment management module includes an encryption unit and a mode selection unit. The encryption unit is used to encrypt and decrypt the card, and the mode selection unit is used to set the experiment mode.

8. A randomized controlled trial system for transcranial magnetic stimulation according to claim 1, characterized in that: The experiment management module includes a sample stratification unit, and the sample stratification unit is used to perform stratified screening on the experimental samples.

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