Brain stereotaxic apparatus
By using laser positioning components for skull annotation in the brain stereotactic instrument, the problems of inaccurate marking and wound infection were solved, and a more accurate and safe experimental process was achieved.
Patent Information
- Application Number
- CN202422755897.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-12
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2034-11-12
AI Technical Summary
When marking the skull position of the existing brain stereotactic instrument, the signature pen is inaccurately marked and there is a risk of wound infection, which affects the experimental effect.
Laser positioning components are used for annotation, and by adjusting the positions of the crossbar, slider and laser head, a fine spot is formed to ensure the accurate position of the skull drilling.
More precise skull labeling is achieved, reducing experimental errors, and reducing the risk of wound infection and improving the reliability of the experiment.
Smart Images
Figure CN222657254U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the field of brain science experiments and relates to a brain stereotaxic instrument. Background Art
[0002] A stereotaxic apparatus, also known as a brain fixation device, uses a three-dimensional coordinate system defined by landmarks on the outside of the skull or other reference points to determine the location of certain subcortical neural structures so that they can be stimulated, destroyed, injected with drugs, guided with potentials, and studied in a non-direct exposure environment.
[0003] In current technology, after fixing the head of an animal, for example, fixing the head of an experimental mouse, part of the fur on the head of the experimental mouse is removed, and the skull of the corresponding area is exposed. According to the brain area to be tested, the probe is pointed to the corresponding position of the skull through the stereotaxic instrument, and marked with a signature pen, and then a cranial drill is used to drill a hole in the marked position to provide conditions for subsequent injection of drugs, etc.
[0004] However, when using a signature pen to mark, the handwriting is thick, so there is a problem of inaccurate positioning, and the signature pen is not easy to leave marks on the skull. In addition, marking with a signature pen on the surface of the skull also poses a risk of wound infection in experimental mice, affecting the experimental results. Utility Model Content
[0005] In order to overcome the defects in the above-mentioned related technologies, the utility model provides a brain stereotaxic instrument, which can use laser for marking without affecting the normal operation of the experiment.
[0006] To achieve the above technical objectives, the utility model provides a brain stereotaxic instrument. The brain stereotaxic instrument comprises: a U-shaped base, an operating arm and a first laser positioning assembly. The operating arm is fixed to one side of the U-shaped base, and the operating arm comprises a Y-shaped operating arm in the vertical direction. The first laser positioning assembly is fixed on the U-shaped base.
[0007] Wherein, the first laser positioning assembly includes: a vertical rod, a cross rod, a slider, a laser head and a power supply. The vertical rod is connected to the U-shaped base, the vertical rod has a tendency to rotate around its vertical center line, and the vertical rod is connected to the U-shaped base through a damping shaft. The cross rod is horizontally arranged, and the cross rod is fixedly connected to the upper part of the vertical rod, and the cross rod is higher than the Y-shaped operating arm. The slider is a block structure, and a through hole is arranged on the slider. At least one of the sliders is movably arranged on the cross rod, and a damping is arranged between the slider and the cross rod. A laser head is arranged on each slider. The power supply is fixed to the cross rod, and the power supply is electrically connected to the laser head.
[0008] Preferably, the U-shaped base includes the ear rod. When the orthographic projections of the cross bar and the ear rod on the plane are perpendicular to each other, both sides of the orthographic projection of the ear rod on the horizontal plane have the orthographic projection of the cross bar on the horizontal plane.
[0009] Preferably, an anti-slip piece is provided at the end of the cross bar away from the vertical bar, the anti-slip piece is a block-shaped structure, and the diameter of the anti-slip piece is greater than the diameter of the cross bar.
[0010] Preferably, the operating arm further comprises a Z-shaped operating arm, and the Z-shaped operating arm is horizontally arranged on the Y-shaped operating arm. The vertical rod is arranged on a side of the Z-shaped operating arm away from the ear rod.
[0011] Preferably, the U-shaped base comprises: a first base and two parallel second bases, the first base and the second base are rods, and a second base is fixed to each end of the first base in a one-to-one correspondence. The vertical rod is fixed at the connection position of the first base and the second base.
[0012] Preferably, the brain stereotaxic instrument also includes the second laser positioning component, the second laser positioning component has the same structure as the first laser positioning component, and the second laser positioning component is symmetrical to the first laser positioning component about the vertical center plane of the U-shaped base.
[0013] The beneficial effects of the utility model are:
[0014] First, the utility model adopts the first laser positioning component, after the probe locates the corresponding position of the skull, by adjusting the position of the crossbar, slider, and laser head, the laser forms a light spot at the corresponding position of the skull, and the light spot is thin, which can provide an accurate skull drilling position. In addition, multiple laser heads can emit lasers from multiple directions and form light spots at the same position, which can avoid the hand, arm, and operating equipment blocking the light during the experiment and affecting the experiment.
[0015] Second, the utility model adopts a second laser positioning component, which can be set according to different sides of the animal's head, so that it can adapt to different types of experiments. In addition, the second laser positioning component emits laser from the other side, and the possibility of two sets of lasers being blocked at the same time is lower, which can always ensure that there is a light spot at the corresponding position of the skull. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the technical solutions in the embodiments of the utility model or the related technologies, the drawings required for use in the embodiments or the related technical descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.
[0017] Figure 1 It is a structural diagram of the utility model;
[0018] Figure 2 It is a side structural diagram of the utility model;
[0019] Figure 3 It is a structural diagram of the base, the first laser positioning component and the second laser positioning component of the utility model. DETAILED DESCRIPTION
[0020] In order to make the above-mentioned purposes, features and advantages of the utility model more obvious and easy to understand, the technical scheme in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is only a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of the utility model.
[0021] In the description of the present invention, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation on the present invention.
[0022] The terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, unless otherwise specified, "plurality" means two or more. Example
[0023] The brain stereotaxic instrument comprises: a U-shaped base 1, an operating arm 2 and a first laser positioning assembly 3. The operating arm 2 is fixed to one side of the U-shaped base 1, and the operating arm 2 comprises a Y-shaped operating arm 21 in the vertical direction. The first laser positioning assembly 3 is fixed on the U-shaped base 1.
[0024] Wherein, the first laser positioning assembly 3 includes: a vertical rod 31, a cross rod 32, a slider 33, a laser head 34 and a power supply. The vertical rod 31 is connected to the U-shaped base 1, and the vertical rod 31 has a tendency to rotate around its vertical center line, and the vertical rod 31 is connected to the U-shaped base 1 through a damping shaft. The cross rod 32 is arranged horizontally, and the cross rod 32 is fixedly connected to the upper part of the vertical rod 31, and the cross rod 32 is higher than the Y-shaped operating arm 21. The slider 33 is a block structure, and a through hole is arranged on the slider 33. At least one slider 33 is movably arranged on the cross rod 32, and a damping is arranged between the slider 33 and the cross rod 32. A laser head 34 is arranged on each slider 33. The power supply is fixed to the cross rod 32, and the power supply is electrically connected to the laser head 34.
[0025] The U-shaped base 1 includes the ear rod 11. When the orthographic projections of the cross bar 32 and the ear rod 11 on the plane are perpendicular to each other, both sides of the orthographic projection of the ear rod 11 on the horizontal plane have the orthographic projection of the cross bar 32 on the horizontal plane, that is, the cross bar 32 extends from one end of the U-shaped base 1 to the ear rod 11 and exceeds the ear rod 11.
[0026] An anti-dropping piece is disposed at the end of the cross bar 32 away from the vertical bar 31 . The anti-dropping piece is a block-shaped structure, and the diameter of the anti-dropping piece is greater than the diameter of the cross bar 32 .
[0027] The operating arm 2 further comprises a Z-shaped operating arm 22, and the Z-shaped operating arm 22 is horizontally arranged on the Y-shaped operating arm 21. The vertical rod 31 is arranged on a side of the Z-shaped operating arm 22 away from the ear rod 11.
[0028] In some examples, the stereotaxic apparatus further includes a bottom plate, which may be a square plate, the upper end surface of which is horizontal, a U-shaped base 1 is fixed to the bottom plate, a first base and two parallel second bases, the first base and the second base are rods, and a second base is fixed to each of the two ends of the first base. The U-shaped base 1 is a U-shaped structure as a whole, a front tooth hook is provided on the first base and located inside the U-shaped base 1, and ear rods 11 are provided on the two second bases away from the first base.
[0029] An operating arm 2 is fixed to one side of the base, and the operating arm 2 includes: an X-type operating arm, a Y-type operating arm 21 and a Z-type operating arm 22. The X-type operating arm includes a rod parallel to the second base on a horizontal plane, the Y-type operating arm 21 is arranged on the X-type operating arm, and the Y-type operating arm 21 can rotate with a vertical line as an axis, and the Y-type operating arm 21 can include a guide rail in the vertical direction. The Z-type operating arm 22 is fixed on the Y-type operating arm 21, the Z-type operating arm 22 includes a guide rail in the horizontal direction, and a clamp is arranged on the Z-type operating arm 22, and the clamp can clamp a probe, etc.
[0030] A first laser positioning assembly 3 is arranged on the U-shaped base 1, and a vertical rod 31 of the first laser positioning assembly 3 is connected to the U-shaped base 1 through a damping bearing. That is, the vertical rod 31 can be manually twisted to rotate around its center line. A crossbar 32 is fixed to the upper end of the vertical rod 31, and the crossbar 32 is arranged horizontally. A plurality of sliders 33 are mounted on the crossbar 32. The surface of the crossbar 32 is smooth, and the sliders 33 and the crossbar 32 are damped, that is, the sliders 33 can be manually moved to reciprocate along the extension direction of the crossbar 32, and when there is no external force intervention, the sliders 33 are stationary on the crossbar 32.
[0031] A laser head 34 is arranged on each slider 33, and a rotating member 35 can be arranged between the slider 33 and the laser head 34. The rotating member 35 can be a block structure, and the rotating member 35 is connected to the slider 33 through a damping shaft. The laser head 34 is fixed on the rotating member 35. When the rotating member 35 is manually turned, the laser head 34 can be driven to rotate, so that the laser can swing within a certain range below the cross bar 32.
[0032] For example, the rotating member 35 can be a cylindrical rod, a bottom surface of the rotating member 35 is connected to the slider 33 through a damping shaft, and the side wall of the rotating member 35 is fixed with the laser head 34 .
[0033] The laser head 34 also includes a power source, which may be a button battery. The power source may be disposed in the rotating member 35 . A switch is also disposed between the power source and the laser head 34 , and the switch is fixed on the housing of the rotating member 35 .
[0034] When in use, the head of an experimental animal, such as an experimental mouse, is fixed between the U-shaped bases 1. When the probe points to the skull, the vertical rod 31 can be rotated, the plurality of sliders 33 can be moved, and the rotating member 35 can be twisted to form a laser spot on the skull surface where the probe points.
[0035] The crossbar 32 extends from the first base to the other side of the ear bar 11, so as to facilitate the movement of the slider 33 to the back of the head of the experimental animal, and can adapt to different brain experiments.
[0036] It is understandable that, in order to facilitate the experiment, the laser spot on the skull surface may disappear due to obstruction, and multiple sliders 33 and laser heads 34 can be set to ensure that there are consistent marks on the skull surface to ensure the normal progress of the experiment.
[0037] A cranial drill or injection needle can then be used to follow the markings. Example
[0038] On the basis of Example 1, the U-shaped base 1 described in this embodiment includes: a first base and two parallel second bases, the first base and the second base are rods, and a second base is fixed to each end of the first base in a one-to-one correspondence. The vertical rod 31 is fixed at the connection position of the first base and the second base.
[0039] The connection position between the first base and the second base is wide and does not affect the experimental operation, and is an ideal position for arranging the vertical rod 31 . Example
[0040] Based on Example 1 or Example 2, the brain stereotaxic instrument described in this embodiment also includes the second laser positioning component 4, the second laser positioning component 4 has the same structure as the first laser positioning component 3, and the second laser positioning component 4 is symmetrical to the first laser positioning component 3 about the vertical center plane of the U-shaped base 1.
[0041] The second laser positioning component 4 is used in the same way as the first laser positioning component 3. In the experiment, only the first laser positioning component 3 or the second laser positioning component 4 can be used, or the first laser positioning component 3 and the second laser positioning component 4 can be used together. When used at the same time, the first laser positioning component 3 and the second laser positioning component 4 shoot lasers at the skull from different sides. During the experimental operation, it is easier to retain the light spot on the skull surface, which can improve the convenience of the experiment.
[0042] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.
[0043] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited to this. Any changes or substitutions that can be easily thought of by technicians familiar with the technical field within the technical scope disclosed by the utility model should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.
Claims
1. A brain stereotaxic instrument, characterized in that: include: U-shaped base; An operating arm, the operating arm is fixed to one side of the U-shaped base, and the operating arm includes a Y-shaped operating arm in the vertical direction; A first laser positioning component, wherein the U-shaped base is fixed with a first laser positioning component; Wherein, the first laser positioning component comprises: A vertical rod, the vertical rod is connected to the U-shaped base, the vertical rod has a tendency to rotate around its vertical center line, and the vertical rod is connected to the U-shaped base through a damping shaft; A cross bar, which is arranged horizontally and fixedly connected to the upper part of the vertical bar, and is higher than the Y-shaped operating arm; A slider, wherein the slider is a block structure, a through hole is provided on the slider, at least one of the sliders is movably provided on the cross bar, and a damping is provided between the slider and the cross bar; Laser head, each slider is provided with a laser head; A power supply is fixed to the cross bar and is electrically connected to the laser head.
2. The brain stereotaxic instrument according to claim 1, characterized in that: The U-shaped base includes ear rods; When the orthographic projections of the cross bar and the ear bar on the plane are perpendicular to each other, both sides of the orthographic projection of the ear bar on the horizontal plane have the orthographic projection of the cross bar on the horizontal plane.
3. The brain stereotaxic instrument according to claim 2, characterized in that: An anti-dropping piece is arranged at the end of the cross bar away from the vertical bar. The anti-dropping piece is a block structure, and the diameter of the anti-dropping piece is greater than the diameter of the cross bar.
4. The brain stereotaxic instrument according to claim 3, characterized in that: The operating arm further comprises a Z-shaped operating arm, and the Z-shaped operating arm is horizontally arranged on the Y-shaped operating arm; The vertical rod is arranged on a side of the Z-shaped operating arm away from the ear rod.
5. The brain stereotaxic instrument according to claim 4, characterized in that: The U-shaped base comprises: a first base and two parallel second bases, the first base and the second base are rods, and a second base is fixed to both ends of the first base in a one-to-one correspondence; The vertical rod is fixed at the connection position between the first base and the second base.
6. The brain stereotaxic instrument according to claim 5, characterized in that: The brain stereotaxic instrument also includes a second laser positioning component, which has the same structure as the first laser positioning component and is symmetrical to the first laser positioning component about the vertical center plane of the U-shaped base.