Combined artificial kidney integrated pipeline

Abstract

The combined artificial kidney integrated pipeline comprises a dialyzer, an outlet main pipe, an inlet main pipe and an outlet main pipe, an inlet of the perfusion device assembly is connected with the inlet header pipe, and the perfusion device assembly comprises a first perfusion device and a second perfusion device which are connected in parallel; the filtering pre-flushing assembly is connected between the perfusion device assembly and the dialyzer in series, an inlet of the filtering pre-flushing assembly is connected with an outlet of the perfusion device assembly, and an outlet of the filtering pre-flushing assembly is connected with an inlet of the dialyzer; and the bypass pipeline is connected with the first perfusion device in parallel. The perfusion device assembly comprises at least two perfusion devices connected in parallel and is provided with the bypass pipeline connected with the perfusion devices in parallel, the connection state of the perfusion devices can be changed through the bypass pipeline, and the perfusion devices are connected in parallel or in series, so that free switching of series connection / parallel connection modes between the perfusion devices can be achieved according to the requirements of treatment modes, and the treatment efficiency is improved. The operation of detaching and replacing the perfusion device in the treatment process is avoided, and the infection opportunity is reduced.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a combined artificial kidney integrated pipeline for hemodialysis treatment. Background Art

[0002] Combined artificial kidney is a device that replaces kidney function and is mainly used to treat renal failure and uremia. Currently, the dialyzer and perfusion device are often used in series in clinical practice. The principles of dialysis, filtration, adsorption, membrane separation, etc. are used to eliminate nitrogen compounds, metabolic products or excessive drugs carried in the blood and regulate electrolyte balance. This treatment method combines the advantages of hemoperfusion and hemodialysis to achieve better treatment effects.

[0003] At present, when combined artificial kidneys are used for treatment, the perfusion device and dialyzer are often connected in series for 2 hours before the dialyzer is used alone for 2 hours. Therefore, the circuit circulation is required to achieve at least two modes: perfusion + dialysis and single dialysis. In actual operation, the following technical problems may be encountered:

[0004] 1) The treatment time of the dialyzer is 4 hours, and the treatment time of the perfusion device is 2 hours. After the perfusion device and dialyzer are used in series for 2 hours, the perfusion device should be removed and the dialyzer should be used alone for another 2 hours. During the removal of the pipeline, the dialyzer connection end and the patient's dialysis tube may be exposed to the air. Bacteria and dust in the air can easily enter the dialyzer and blood pipeline through the open end, causing contamination or infection, causing unnecessary harm to the patient.

[0005] 2) The adsorbent in the perfusion device is generally a neutral macroporous adsorption resin that has been treated by a special process. The dialyzer and the perfusion device are used in series. During the pre-flushing process before treatment, if the normal saline passes through the perfusion device first and then enters the dialyzer through the pipeline, the normal saline passing through the perfusion device may cause secondary contamination to the dialyzer. The resin fragments and small particles that fall off from the perfusion device may cause blockage of the dialyzer, affecting the effectiveness of the dialyzer and causing other safety hazards.

[0006] 3) During the treatment, improper use of anticoagulants such as heparin, poor blood circulation or slow blood flow can easily cause coagulation in the perfusion device. Once coagulation occurs in the perfusion device, the blood circuit must be disconnected and the coagulation perfusion device and related pipes must be removed. In the process of removing the coagulation perfusion device and related pipes, the risk of blood purification treatment is greatly increased. Utility Model Content

[0007] The utility model aims to provide a combined artificial kidney integrated pipeline which is easy to operate and can reduce the possibility of pollution.

[0008] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0009] The combined artificial kidney integrated pipeline comprises: a dialyzer, wherein the outlet of the dialyzer is connected to an outlet main pipe; a perfusion device assembly, wherein the inlet of the perfusion device assembly is connected to an inlet main pipe, and the perfusion device assembly comprises a first perfusion device and a second perfusion device connected in parallel; a filtering pre-flushing assembly connected in series between the perfusion device assembly and the dialyzer, wherein the inlet of the filtering pre-flushing assembly is connected to the outlet of the perfusion device assembly, and the outlet is connected to the inlet of the dialyzer; and a bypass pipeline, wherein the bypass pipeline is connected in parallel to the first perfusion device.

[0010] It can be seen from the above technical scheme that the cartridge assembly of the utility model includes at least two cartridges connected in parallel, and is provided with a bypass pipeline connected in parallel with the cartridges. The connection state of the cartridges can be changed by switching on and off the bypass pipeline and the corresponding pipeline, and the cartridges can be connected in parallel or in series. Therefore, according to the requirements of the treatment mode, the series / parallel connection mode between the cartridges can be freely switched, eliminating the operation of removing and replacing the cartridges during the treatment process, and reducing the chance of infection.

[0011] As described above, the combined artificial kidney integrated pipeline, optionally, the bypass pipeline is connected between the inlet of the cartridge assembly and a fourth connecting pipeline connected to the inlet of the filter pre-flushing assembly, and the filter pre-flushing assembly is connected to the outlet of the cartridge assembly through the fourth connecting pipeline.

[0012] Furthermore, the filter pre-flushing component includes a particle filter, a waste liquid pipeline, a waste liquid bag and a second filter pre-flushing pipeline, the outlet of the fourth connecting pipeline is connected to the inlet of the second filter pre-flushing pipeline, the particle filter is arranged on the second filter pre-flushing pipeline, the waste liquid pipeline is connected to the inlet of the filter pre-flushing component, and the other end of the waste liquid pipeline is connected to the waste liquid bag.

[0013] Adding a particle filter to the filtration priming pipeline to filter out impurity particles in the priming fluid such as saline passing through the perfusion device can prevent the priming fluid from causing secondary contamination to the dialyzer, affecting the effectiveness of the dialyzer and causing other safety hazards.

[0014] Furthermore, the filter pre-flushing component also includes a thrombus filter and a first filter pre-flushing pipeline, the outlet of the fourth connecting pipeline is connected to the first filter pre-flushing pipeline, and the thrombus filter is arranged on the first filter pre-flushing pipeline.

[0015] A thrombus filter is provided in the filtration pre-flushing pipeline. The thrombus filter is located at the outlet of the dialyzer and is used to intercept thrombi that may be generated during the perfusion treatment process. This can reduce the possibility of thrombi entering the dialyzer and clogging the membrane pores.

[0016] Furthermore, the inlet main pipe is connected to the first perfusion device and the second perfusion device respectively through a first connecting pipeline and a second connecting pipeline; the inlet of the dialyzer is connected to the outlet of the filter pre-flushing component through a third connecting pipeline; the first perfusion device is connected to the fourth connecting pipeline through a fifth connecting pipeline, and the second perfusion device is connected to the fourth connecting pipeline through a sixth connecting pipeline.

[0017] Furthermore, the waste liquid pipeline, the first filter pre-flushing pipeline and the second filter pre-flushing pipeline are provided with tube clamps for controlling the opening and closing of the connecting pipelines, and the tube clamps on the first filter pre-flushing pipeline and the second filter pre-flushing pipeline are respectively located before the inlets of the thrombus filter and the particle filter.

[0018] Furthermore, the first connecting pipeline and the second connecting pipeline are provided with pipe clamps;

[0019] And / or, pipe clamps are provided on the bypass pipeline and the sixth connecting pipeline.

[0020] Furthermore, the fourth connecting pipeline is connected to the fifth connecting pipeline and the sixth connecting pipeline via a one-way three-way valve;

[0021] And / or, the third connecting pipeline is connected to the first filter pre-flushing pipeline and the second filter pre-flushing pipeline via a one-way three-way valve;

[0022] And / or, the outlet side of the bypass pipeline is connected to the fifth connecting pipeline or the sixth connecting pipeline through a one-way three-way valve.

[0023] Using a one-way three-way valve instead of a traditional three-way connector can avoid the backflow of priming fluid / blood and ensure the stability of the priming fluid / blood flow in the system. At the same time, it reduces the number of tube clamps used, simplifies the pipeline structure, and makes clinical operation more convenient.

[0024] Furthermore, the fifth connecting pipeline and the sixth connecting pipeline are provided with sampling ports, and the sampling ports are respectively located behind the outlet of the first perfusion device and behind the outlet of the second perfusion device.

[0025] Furthermore, a sampling port is provided on the fourth connecting pipeline.

[0026] A sampling port is added at the outlet of the perfusion device to sample and test the blood after perfusion treatment, helping medical staff to scientifically judge the timing of switching the perfusion device. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the embodiments of the utility model, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0028] Figure 1 It is a structural schematic diagram of an embodiment of the utility model.

[0029] The specific implementation of the utility model is further described in detail below with reference to the accompanying drawings. DETAILED DESCRIPTION

[0030] The utility model is described in detail below in conjunction with the accompanying drawings. When describing the embodiments of the utility model in detail, for the convenience of explanation, the drawings representing the device structure will not be partially enlarged according to the general proportion, and the schematic diagram is only an example, which should not limit the scope of protection of the utility model. It should be noted that the drawings are simplified in form and use non-precise proportions, which are only used to facilitate and clearly assist in explaining the purpose of the embodiments of the utility model. At the same time, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated; the terms "positive", "negative", "bottom", "upper", "lower", etc. indicate the orientation or position relationship based on the orientation or position relationship shown in the drawings, which is only for the convenience of describing the utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0031] In the description of the present utility model, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, it can also be the internal connection of two elements, it can be a wireless connection, or it can be a wired connection. For ordinary technicians in this field, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0032] like Figure 1 As shown, the combined artificial kidney integrated pipeline of this embodiment includes a dialyzer 1, a first perfusion device 2, a second perfusion device 3, a filter pre-flushing assembly 4, an inlet manifold 5, and an outlet manifold 6. Among them, the filter pre-flushing assembly 4 includes a thrombus filter 4-1, a particle filter 4-2, a waste liquid pipeline 4-3, a waste liquid bag 4-4, and corresponding connecting pipelines. The first perfusion device 2 and the second perfusion device 3 and the corresponding connecting pipelines constitute a perfusion device assembly.

[0033] One end of the inlet manifold 5 is connected to the human artery end pipeline (not shown), and the other end (the end away from the human artery end) is connected to the first perfusion device 2 and the second perfusion device 3 through the first connecting pipeline 7 and the second connecting pipeline 8. The first connecting pipeline 7 and the second connecting pipeline 8 of this embodiment are connected to the inlet manifold 5 through a three-way joint T.

[0034] One end of the outlet main pipe 6 is connected to the human body venous end pipeline, and the other end (the end away from the human body venous end) is connected to the outlet of the dialyzer 1. The inlet of the dialyzer 1 is connected to the outlet of the filter pre-flushing component 4 through the third connecting pipeline 9. The inlet of the filter pre-flushing component 4 is connected to the outlet of the cartridge assembly through the fourth connecting pipeline 10, that is, the filter pre-flushing component 4 is connected in series between the cartridge assembly and the dialyzer 1. In this embodiment, the outlet of the first cartridge 2 is connected to the fifth connecting pipeline 11, and the outlet of the second cartridge 3 is connected to the sixth connecting pipeline 12. The fifth connecting pipeline 11 and the sixth connecting pipeline 12 are connected to the fourth connecting pipeline 10 through a three-way joint T, so that the outlets of the first cartridge 2 and the second cartridge 3 are connected to the inlet of the filter pre-flushing component 4.

[0035] A bypass pipeline 13 is connected between the inlet of the cartridge assembly and the fourth connecting pipeline 10, and the bypass pipeline 13 is in parallel with the first cartridge 2 / the second cartridge 3. The two ends of the bypass pipeline 13 of this embodiment are respectively connected to the first connecting pipeline 7 and the sixth connecting pipeline 12 through a three-way joint T. In other embodiments, the bypass pipeline 13 can also be connected to the fifth connecting pipeline 11 and the second connecting pipeline 8 through a three-way joint.

[0036] The inlet of the first perfusion device 2 is connected to the first connecting pipeline 7, and the inlet of the second perfusion device 3 is connected to the second connecting pipeline 8. In this embodiment, two tube clamps J are provided on the first connecting pipeline 7, and the two tube clamps J are respectively located on the front side and the rear side of the three-way joint T on the first connecting pipeline 7. A tube clamp J is also provided on the second connecting pipeline 8. The tube clamp J is used to control the conduction and disconnection of the connecting pipeline, thereby controlling the flow direction of the fluid in the integrated pipeline, so as to switch the flow direction of the priming liquid and the blood treatment mode according to the treatment needs. Tube clamps J are also respectively provided on the sixth connecting pipeline 12 and the bypass pipeline 13 of this embodiment. In this embodiment, two tube clamps J are provided on the sixth connecting pipeline 12, and the two tube clamps J are respectively located on the front side and the rear side of the three-way joint T on the sixth connecting pipeline 12.

[0037] The filter pre-flushing assembly 4 is used to pre-flushing the perfusion device and / or the dialyzer before treatment. The fourth connecting pipeline 10 is connected to the first filter pre-flushing pipeline 14 and the second filter pre-flushing pipeline 15 through a three-way joint T, wherein the thrombus filter 4-1 is arranged on the first filter pre-flushing pipeline 14, and the particle filter 4-2 is arranged on the second filter pre-flushing pipeline 15. The thrombus filter 4-1 is used to filter thrombi, and the particle filter 4-2 is used to filter foreign particles in the pre-flushing liquid. The waste liquid pipeline 4-3 is connected to the inlet of the filter pre-flushing assembly 4 through a three-way joint T. The waste liquid pipeline 4-3 of this embodiment is connected to the second filter pre-flushing pipeline 15 through a three-way joint T, and is connected before the inlet of the particle filter 4-2; in other embodiments, the waste liquid pipeline 4-3 can also be connected to the first filter pre-flushing pipeline 14 through a three-way joint T, and is connected before the inlet of the thrombus filter 4-1. The other end of the waste liquid pipeline 4-3 is connected to the waste liquid bag 4-4. The first filter pre-flushing pipeline 14 and the second filter pre-flushing pipeline 15 are connected to the third connecting pipeline 9 connected to the inlet of the dialyzer 1 through a three-way connector T. Tube clamps J are provided on the waste liquid pipeline 4-3, the first filter pre-flushing pipeline 14 and the second filter pre-flushing pipeline 15. The tube clamps J on the first filter pre-flushing pipeline 14 and the second filter pre-flushing pipeline 15 are respectively located before the inlets of the thrombus filter 4-1 and the particle filter 4-2. The tube clamps J can control whether the fluid can enter the thrombus filter 4-1 and the particle filter 4-2.

[0038] Optionally, in order to accurately detect the state of the blood after perfusion, a sampling port 17 is provided on the fifth connecting line 11 and the sixth connecting line 12, and the sampling port 17 is respectively located after the outlet of the first perfusion device 2 and after the outlet of the second perfusion device 3. Furthermore, a sampling port 17 is also provided on the fourth connecting line 10, which can be used to sample and test the blood after the perfusion, which helps medical staff to determine the timing of replacing the perfusion device. By sampling and testing the blood flowing out of the perfusion device to determine whether the adsorption of the perfusion device has reached the limit state, and thus switching different perfusion devices, it is more scientific and accurate than conventionally judging whether to replace the perfusion device by time (such as 2 hours).

[0039] Optionally, in order to prevent the priming liquid / blood from flowing back and ensure the stability of the priming liquid / blood flow in the system, the three-way joint T connecting the fourth connecting pipeline 10, the fifth connecting pipeline 11 and the sixth connecting pipeline 12, the three-way joint T connected to the outlet side of the bypass pipeline 13, and the three-way joint T connecting the third connecting pipeline 9 and the first filter pre-flushing pipeline 4-1 and the second filter pre-flushing pipeline 4-2 are one-way three-way valves, which only allow the fluid to flow in accordance with Figure 1 The flow direction is indicated by the arrow, but the flow in the opposite direction is not allowed. The use of a one-way three-way valve can also reduce the number of tube clamps, making it easier for medical staff to operate and saving production costs.

[0040] The combined artificial kidney integrated pipeline of the utility model is provided with at least two parallel perfusion devices and a bypass pipeline in parallel with the perfusion devices. By shutting off / conducting the corresponding connecting pipelines, pre-flushing modes such as pre-flushing the parallel perfusion devices alone, pre-flushing the dialyzer alone, and pre-flushing the perfusion devices and the dialyzer in series can be realized without disassembling the pipeline components. Figure 1 , different priming modes are explained.

[0041] Separately pre-flushing the parallel perfusion apparatus: open the tube clamps J on the first connecting line 7, the second connecting line 8, the sixth connecting line 12 and the waste liquid line 4-3, and close the other tube clamps J; after the pre-flushing liquid enters from the inlet manifold 5, it passes through the first connecting line 7→the first perfusion apparatus 2→the fifth connecting line 11→the fourth connecting line 10→the waste liquid line 4-3→the waste liquid bag 4-4 ​​in sequence to pre-flushing the first perfusion apparatus 2, and at the same time, passes through the second connecting line 8→the second perfusion apparatus 3→the sixth connecting line 12→the fourth connecting line 10→the waste liquid line 4-3→the waste liquid bag 4-4 ​​in sequence to pre-flushing the second perfusion apparatus 3.

[0042] Separate pre-flushing of the dialyzer: connect a waste liquid bag (not shown) to the outlet end of the outlet main pipe 6, open the bypass line 13, the tube clamps J on the first filter pre-flushing line 14, the tube clamp J on the first connecting line 7 close to the inlet main pipe 5, and the tube clamp J on the sixth connecting line 12 close to the inlet of the fourth connecting line 10, and close the remaining tube clamps J; after the pre-flushing liquid enters from the inlet main pipe 5, it passes through part of the first connecting line 7 → bypass line 13 → part of the sixth connecting line 12 → fourth connecting line 10 → first filter pre-flushing line 14 (thrombus filter 4-1) → third connecting line 9 → dialyzer 1 → waste liquid bag in sequence, and the dialyzer 1 is pre-flushed.

[0043] Pre-flushing two cartridges and a dialyzer in series: connect a waste liquid bag (not shown) to the outlet end of the outlet main pipe 6, open the tube clamps J on the second connecting line 8, the bypass line 13, the second filter pre-flushing line 15, and the tube clamp J on the sixth connecting line 12 near the outlet of the second cartridge 3 and the tube clamp J on the first connecting line 7 near the inlet of the first cartridge 2, and close the remaining tube clamps J to change the flow direction of the pre-flushing liquid; after the pre-flushing liquid enters from the inlet main pipe 5, it passes through the second connecting line 8→the second cartridge 3→a part of the sixth connecting line 12→the bypass line 13→a part of the first connecting line 7→the first cartridge 2→the fifth connecting line 11→the fourth connecting line 10→the second filter pre-flushing line 15 (particle filter 4-2)→the third connecting line 9→the dialyzer 1→the waste liquid bag in sequence.

[0044] When the perfusion device is pre-flushed, since the adsorbent in the perfusion device may contain adsorbent fragments, if the pre-flushing liquid after passing through the perfusion device is directly used to pre-flushed the dialyzer, the pre-flushing liquid containing adsorbent fragments may cause secondary contamination to the dialyzer, affecting the effectiveness of the dialyzer. Therefore, in this embodiment, a particle filter is added to the pipeline before entering the dialyzer, which can effectively intercept possible particles in the pre-flushing liquid, reduce the risk of particles entering the blood, and effectively solve the problem of secondary contamination. In the above-mentioned pre-flushing step, the entire pipeline system is always in a closed state, and there is no need to disassemble the pipeline, which can avoid safety hazards caused by pollution of the surrounding environment.

[0045] During dialysis treatment, some patients have a high concentration of macromolecular toxins in their blood. When there is only one perfusion pump, the adsorption effect of the single perfusion pump may not be sufficient to complete the entire treatment process, and the perfusion pump needs to be replaced midway. The utility model can achieve a combined treatment mode of series perfusion of the first and second perfusion pumps + dialyzer dialysis by changing the flow of the pipeline without removing the pipeline assembly or connecting a new pipeline assembly.

[0046] In the first / second perfusion device perfusion + dialyzer dialysis treatment mode, the tube clamps J on the first connecting pipeline 7 and the first filter pre-flushing pipeline 14 are opened, and the other tube clamps J are closed; after the blood enters from the inlet main pipe 5, it passes through the first perfusion device 2 and the dialyzer 1 in sequence, and the series treatment of the first perfusion device 2 + the dialyzer 1 is realized; when the blood state at the outlet position of the first perfusion device 2 after a period of series treatment is detected by the sampling port 17 arranged after the outlet of the first perfusion device 2, when it is found that the adsorption effect of the first perfusion device has reached the limit and the treatment effect is insufficient, the series treatment of the second perfusion device 3 + the dialyzer 1 is switched, and the tube clamp J on the first connecting pipeline 7 is closed, and the tube clamps J on the second connecting pipeline 8 and the sixth connecting pipeline 12 are opened, the tube clamp J on the first filter pre-flushing pipeline 14 is kept open, and the other tube clamps J are kept closed, and after the blood enters from the inlet main pipe 5, it passes through the second perfusion device 3 and the dialyzer 1 in sequence, and the series treatment of the second perfusion device 3 + the dialyzer 1 is realized.

[0047] For the mode of the front-end treatment as a perfusion device + dialyzer and the back-end treatment as a single dialyzer, it can be achieved by switching the conduction or disconnection of the bypass line 13 connected in parallel with the first / second perfusion device. Taking the treatment of the first perfusion device + dialyzer as an example, at the beginning, the tube clamps J on the first connecting line 7 and the first filter pre-flushing line 14 are opened, and the remaining tube clamps J are closed; after the blood enters from the inlet main pipe 5, it passes through the first perfusion device 2 and the dialyzer 1 in sequence, and the series treatment of the first perfusion device 2 + dialyzer 1 is realized; then, the tube clamp J on the first connecting line 7 near the inlet of the first perfusion device 2 is closed, the tube clamp J on the bypass line 13 and the tube clamp J on the sixth connecting line 12 near the inlet of the fourth connecting line 10 are opened, the tube clamp J on the first connecting line 7 near the inlet main pipe 5 and the tube clamp J on the first filter pre-flushing line 14 remain open, and the remaining tube clamps J remain closed, and the dialyzer 1 is used alone for hemodialysis treatment. The treatment process of the second perfusion device + dialyzer is similar, and only the corresponding tube clamps need to be switched to control the on-off of the corresponding connecting pipelines.

[0048] A thrombus filter is added to the pipeline before the blood enters the dialyzer 1. During series treatment, the blood enters the dialyzer after passing through the thrombus filter, which can prevent blood clots (thrombi) generated during the treatment process from flowing into the dialyzer and blocking the fiber membrane pores in the dialyzer, affecting the treatment effect.

[0049] This embodiment can also realize the treatment mode of two perfusion devices connected in series + dialyzer. In this mode, the tube clamp J on the second connecting line 8, the bypass line 13, the first filter pre-flushing line 14, the tube clamp J on the sixth connecting line 12 near the outlet of the second perfusion device 2, and the tube clamp J on the first connecting line 7 near the inlet of the first perfusion device 2 are opened, and the remaining tube clamps J are closed; after the blood enters from the inlet main pipe 5, it passes through the second perfusion device 3, the bypass line 13, the first perfusion device 2, the thrombus filter 4-1 and the dialyzer 1 in sequence, and flows out from the outlet main pipe 6. Compared with conventional treatment methods, in this treatment mode, the blood enters two perfusion devices for adsorption in succession, which can double the clearance rate of medium and large molecular toxins.

[0050] In view of the situation that the patient's blood viscosity is high and thrombus is easy to form, the utility model can also provide a combined treatment mode of dual perfusion devices parallel perfusion + dialyzer dialysis. In this mode, the tube clamps J on the first connecting pipeline 7, the second connecting pipeline 8, the sixth connecting pipeline 12, and the first filter pre-flushing pipeline 14 are opened, and the remaining tube clamps J remain closed; after the blood enters from the inlet main pipe 5, it passes through the first perfusion device 2 and the second perfusion device 3, and then passes through the thrombus filter 4-1 and the dialyzer 1, and flows out from the outlet main pipe 6. The blood is diverted into two perfusion devices for adsorption treatment, and the blood flow entering each perfusion device is reduced by half, which can reduce the probability of blood thrombosis.

[0051] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A combined artificial kidney integrated pipeline, characterized in that: include: A dialyzer, wherein the outlet of the dialyzer is connected to an outlet main pipe; A perfusion device assembly, wherein the inlet of the perfusion device assembly is connected to the inlet manifold, and the perfusion device assembly comprises a first perfusion device and a second perfusion device connected in parallel; A filtration pre-flushing assembly connected in series between the cartridge assembly and the dialyzer, wherein the inlet of the filtration pre-flushing assembly is connected to the outlet of the cartridge assembly, and the outlet is connected to the inlet of the dialyzer; A bypass pipeline is connected in parallel with the first perfusion device.

2. The combined artificial kidney integrated pipeline according to claim 1, characterized in that: The bypass pipeline is connected between the inlet of the cartridge assembly and a fourth connecting pipeline connected to the inlet of the filter pre-flushing assembly, and the filter pre-flushing assembly is connected to the outlet of the cartridge assembly through the fourth connecting pipeline.

3. The combined artificial kidney integrated pipeline according to claim 2, characterized in that: The filter pre-flushing component includes a particle filter, a waste liquid pipeline, a waste liquid bag and a second filter pre-flushing pipeline. The outlet of the fourth connecting pipeline is connected to the inlet of the second filter pre-flushing pipeline. The particle filter is arranged on the second filter pre-flushing pipeline. The waste liquid pipeline is connected to the inlet of the filter pre-flushing component, and the other end of the waste liquid pipeline is connected to the waste liquid bag.

4. The combined artificial kidney integrated pipeline according to claim 3, characterized in that: The filter pre-flushing component also includes a thrombus filter and a first filter pre-flushing pipeline. The outlet of the fourth connecting pipeline is connected to the first filter pre-flushing pipeline, and the thrombus filter is arranged on the first filter pre-flushing pipeline.

5. The combined artificial kidney integrated pipeline according to claim 4, characterized in that: The inlet manifold is connected to the first perfusion device and the second perfusion device through a first connecting pipeline and a second connecting pipeline respectively; The inlet of the dialyzer is connected to the outlet of the filter pre-flushing component via a third connecting pipeline; The first perfusion device is connected to the fourth connection pipeline via a fifth connection pipeline, and the second perfusion device is connected to the fourth connection pipeline via a sixth connection pipeline.

6. The combined artificial kidney integrated pipeline according to claim 4, characterized in that: The waste liquid pipeline, the first filter pre-flushing pipeline and the second filter pre-flushing pipeline are provided with tube clamps for controlling the connection pipeline, and the tube clamps on the first filter pre-flushing pipeline and the second filter pre-flushing pipeline are respectively located before the inlets of the thrombus filter and the particle filter.

7. The combined artificial kidney integrated pipeline according to claim 5, characterized in that: Pipe clamps are provided on the first connecting pipeline and the second connecting pipeline; And / or, pipe clamps are provided on the bypass pipeline and the sixth connecting pipeline.

8. The combined artificial kidney integrated pipeline according to claim 5, characterized in that: The fourth connecting pipeline is connected to the fifth connecting pipeline and the sixth connecting pipeline via a one-way three-way valve; And / or, the third connecting pipeline is connected to the first filter pre-flushing pipeline and the second filter pre-flushing pipeline via a one-way three-way valve; And / or, the outlet side of the bypass pipeline is connected to the fifth connecting pipeline or the sixth connecting pipeline through a one-way three-way valve.

9. The combined artificial kidney integrated pipeline according to claim 5, characterized in that: The fifth connecting pipeline and the sixth connecting pipeline are provided with sampling ports, and the sampling ports are respectively located behind the outlet of the first perfusion device and behind the outlet of the second perfusion device.

10. The combined artificial kidney integrated pipeline according to claim 9, characterized in that: The fourth connecting pipeline is provided with a sampling port.

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