3D cell culture chip structure

Abstract

The utility model discloses a 3D cell culture chip structure which comprises a chip support and chip bodies, a base is fixedly installed at the bottom of the chip support, partition plates are symmetrically installed in the chip support, and the 3D cell culture chip structure further comprises positioning assemblies which are symmetrically arranged on the two sides of the plurality of chip bodies in the chip support, the positioning assembly comprises two groups of sliding grooves which are symmetrically formed in the upper portion of the interior of the chip support in a penetrating mode and located on the two sides of the chip body, positioning blocks are slidably connected to the interiors of the two groups of sliding grooves, two groups of sliding rods are fixedly installed on the sides, away from each other, of the two groups of positioning blocks correspondingly, and the sliding rods are slidably connected with the sliding grooves; one sides of the exteriors of the two groups of sliding rods are sleeved with telescopic springs, and one ends of the telescopic springs are fixedly connected with the chip bracket; and a user can conveniently place and take down the chip body, the chip body can be conveniently positioned, the practicability and convenience are improved, and the practicability is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of cell culture, in particular to a 3D cell culture chip structure. Background Art

[0002] Cell culture refers to a method of simulating the in vivo environment in vitro to allow cells to survive, grow, reproduce and maintain their main structures and functions.

[0003] Publication No. CN217868916U discloses a 3D cell culture chip assembly. This patent can form a universal 3D cell culture chip by providing a cell culture tank for cultured cells to attach on one surface of the core plate and fixing a liquid storage tank on the other surface of the core plate. At the same time, the cultured cells and the culture solution are placed on the two surfaces of the core plate, which is convenient for adding cultured cells and culture solution separately, thereby reducing cross contamination and reducing the number of experimental operation steps. Moreover, when the core plate is rotated, static pressure can be provided for the liquid storage tank to push the culture solution inside it to flow into the cell culture tank. However, this patent still has the following problems in actual use:

[0004] By setting up a cell culture tank and a fixed liquid storage tank, it is convenient to add cultured cells and culture fluid separately, thereby reducing cross contamination and reducing the number of experimental operation steps. However, in actual use, the chip body is fixed inside the chip holder mainly by an elastic limit buckle. When the chip body is taken out, the position of the limit buckle is fixed, and only a pulling force can be applied to the chip body to separate the chip body from the limit buckle, which makes it inconvenient to take out and place the chip body.

[0005] A 3D cell culture chip structure is proposed to solve the above problems. Utility Model Content

[0006] The purpose of the utility model is to provide a 3D cell culture chip structure to solve the problem raised in the above-mentioned background technology that a cell culture tank and a fixed liquid storage tank are currently provided to facilitate the separate addition of cultured cells and culture fluid, thereby reducing cross contamination and reducing the number of experimental operation steps. However, in actual use, the chip body is fixed inside the chip bracket mainly by an elastic limiting buckle. When the chip body is taken out, the position of the limiting buckle is fixed, and only a pulling force can be applied to the chip body to separate the chip body from the limiting buckle, which makes it inconvenient to take out and place the chip body.

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a 3D cell culture chip structure, including a chip bracket and a chip body;

[0008] A base is fixedly installed at the bottom of the chip holder, and a partition is symmetrically installed inside the chip holder;

[0009] Also includes:

[0010] Positioning components are symmetrically arranged on both sides of the chip bodies inside the chip bracket;

[0011] The positioning assembly comprises two sets of sliding grooves symmetrically extending through the upper part of the chip bracket and located on both sides of the chip body, and the two sets of sliding grooves are both slidably connected with positioning blocks, and two sets of sliding rods are fixedly installed on the sides away from the two sets of positioning blocks, and the sliding rods are slidably connected with the sliding grooves;

[0012] Among them, a telescopic spring is sleeved on one side of the outer side of the two groups of sliding rods, and one end of the telescopic spring is fixedly connected to the chip bracket, and a mounting block is fixedly installed on the other end of the telescopic spring, and the mounting block is fixedly connected to the sliding rod, and a fixing sleeve is fixedly installed on the top of the two groups of mounting blocks, and the inside of the fixing sleeve is slidably connected to a support rod, and the support rod is fixedly connected to the chip bracket.

[0013] Preferably, the bottoms of the two groups of mounting blocks are hinged with movable rods, and one end of the movable rod away from the mounting block is hinged with a moving rod, and two groups of push plates are fixedly mounted on the bottoms of the two groups of moving rods respectively.

[0014] Preferably, one side of the outer portion of the two groups of moving rods is sleeved with a positioning sleeve, and the positioning sleeve is slidably connected to the moving rod, and the positioning sleeve is fixedly connected to the chip bracket.

[0015] Preferably, the top of the base is located below several push plates and is symmetrically hinged with several groups of fixing blocks, and limiting rods are hinged between the fixing blocks, and a limiting groove is opened on one side of the bottom of the push plate, and the limiting rod is engaged with the limiting groove.

[0016] Preferably, two groups of support blocks are symmetrically installed on the inner side of the chip bracket below the plurality of chip bodies, and vertical rods are slidably connected inside the two groups of support blocks, and two horizontal bars are fixedly installed on the tops of the two groups of vertical rods.

[0017] Preferably, a compression spring is sleeved on one side of the exterior of the two groups of vertical rods, one end of the compression spring is fixedly connected to the support block, and the other end of the compression spring is fixedly connected to the horizontal bar.

[0018] Preferably, movable grooves are symmetrically provided on the inner side of the chip bracket above the plurality of groups of support blocks, and the horizontal bars are slidably connected to the movable grooves.

[0019] Compared with the prior art, the beneficial effects of the utility model are as follows: the 3D cell culture chip structure has positioning components symmetrically arranged on both sides of the plurality of chip bodies inside the chip bracket, which facilitates the user to place and remove the chip body, facilitates the positioning of the chip body, improves the convenience of practicality, and improves the practicality. The specific contents are as follows:

[0020] 1. Positioning components are symmetrically arranged on both sides of several chip bodies inside the chip bracket. When placing the chip body, the two push plates are pushed upward to move respectively, so that the moving rod can be driven to slide inside the positioning sleeve. After the moving rod moves, the movable rod can be driven to rotate. After the movable rod rotates, the mounting block can be pushed to move. When the mounting block moves, it drives the fixed sleeve to slide on the support rod to limit the movement of the mounting block, thereby driving the sliding rod to move. When the sliding rod moves, the telescopic spring is stretched to retract the positioning block into the sliding groove. Then, the limiting rod between the fixed blocks can be rotated to align the limiting rod with the limiting groove on the push plate. The push plate is released so that the limiting rod and the limiting groove are aligned. The card engagement allows the push plate to be limited, and then the chip body is placed on the top of the two horizontal bars so that the top of the chip body is lower than the bottom of the positioning block, and then the push plate is slightly pushed upward to disengage the limiting rod from the limiting groove, the limiting rod is rotated to release the push plate, and the telescopic spring recovers its deformation, so that the positioning block is reset, and then the positioning block blocks the top two sides of the chip body, so that the chip body can be limited, and when the chip body is removed, the push plate is pushed upward to make the positioning block retract into the sliding groove, so that the chip body loses its limit and can be removed, and the positioning assembly facilitates the placement and removal of the chip body by the user, facilitates the positioning of the chip body, and improves the convenience of practicality and practicality;

[0021] 2. When the chip body is placed on the top of the horizontal bar, the chip body is pressed down, so that the horizontal bar can be driven to slide in the movable groove, and then the vertical rod can be driven to slide on the support block, so that the movement of the vertical rod can compress the compression spring. When the chip body is taken out, the compression spring can restore its deformation after the chip body loses its limit, and then the horizontal bar can lift the chip body, so that it is convenient for the staff to take the chip body, thereby improving practicality. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the top view structure of the utility model;

[0023] Figure 2 This is a front sectional structural schematic diagram of the utility model;

[0024] Figure 3 This is a schematic diagram of the operating structure of the positioning component of the utility model;

[0025] Figure 4 For this utility model Figure 2 A schematic diagram of the enlarged structure of the middle A area;

[0026] Figure 5 For this utility model Figure 3 Schematic diagram of the enlarged structure of area B in the middle.

[0027] In the figure: 1. chip holder; 101. base; 102. chip body; 103. partition; 2. positioning assembly; 201. sliding groove; 202. positioning block; 203. sliding rod; 204. telescopic spring; 205. mounting block; 206. fixing sleeve; 207. support rod; 208. movable rod; 209. moving rod; 210. positioning sleeve; 211. push plate; 212. fixing block; 2121. limiting rod; 213. limiting groove; 214. supporting block; 215. vertical rod; 216. compression spring; 217. horizontal bar; 218. movable groove. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the implementation regulations described are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] See also Figure 1-5The utility model provides a technical solution: a 3D cell culture chip structure, including a chip bracket 1 and a chip body 102, a base 101 is fixedly installed at the bottom of the chip bracket 1, and a partition 103 is symmetrically installed inside the chip bracket 1, and also includes: the chip bracket 1 is symmetrically provided with positioning components 2 on both sides of the plurality of chip bodies 102, wherein the positioning components 2 include two groups of sliding grooves 201 symmetrically penetrating the upper part of the chip bracket 1 and located on both sides of the chip body 102, and the two groups of sliding grooves 201 are slidably connected with positioning blocks 202, and two groups of sliding rods 203 are fixedly installed on the sides away from the two groups of positioning blocks 202, and the sliding rods 203 and the sliding blocks 203 are symmetrically connected with the sliding blocks 202. The groove 201 is slidably connected, wherein a telescopic spring 204 is sleeved on one side of the outside of the two groups of sliding rods 203, and one end of the telescopic spring 204 is fixedly connected to the chip holder 1, and the other end of the telescopic spring 204 is fixedly installed with a mounting block 205, and the mounting block 205 is fixedly connected to the sliding rod 203, and a fixing sleeve 206 is fixedly installed on the top of the two groups of mounting blocks 205, and the inside of the fixing sleeve 206 is slidably connected with a support rod 207, and the support rod 207 is fixedly connected to the chip holder 1. The positioning component 2 facilitates the user to place and remove the chip body 102, facilitates the positioning of the chip body 102, improves the convenience of practicality, and improves practicality.

[0030] The bottom of the two groups of mounting blocks 205 are both hinged with movable rods 208, and one end of the movable rod 208 away from the mounting block 205 is hinged with a moving rod 209, and the bottom of the two groups of moving rods 209 are respectively fixedly installed with two groups of push plates 211, so that the movement of the push plates 211 can drive the mounting block 205 to move, and the outer side of the two groups of moving rods 209 is sleeved with positioning sleeves 210, and the positioning sleeves 210 are slidably connected to the moving rods 209, and the positioning sleeves 210 are fixedly connected to the chip bracket 1 to support and limit the movement of the moving rods 209. The top of the base 101 is located below the several push plates 211 and is symmetrically hinged with several groups of fixed blocks 212, and the fixed blocks 212 are hinged with limiting rods 2121, and a limiting groove 213 is provided on one side of the bottom of the push plate 211, and the limiting rod 2121 is engaged with the limiting groove 213, so that After the push plate 211 moves, it can be limited. The inner side of the chip bracket 1 is located below several chip bodies 102 and is symmetrically equipped with two groups of support blocks 214, and the two groups of support blocks 214 are slidably connected to the inside with vertical rods 215, and two horizontal bars 217 are fixedly installed on the top of the two groups of vertical rods 215, so that the movement of the horizontal bars 217 can drive the vertical rods 215 to move. Compression springs 216 are sleeved on one side of the outside of the two groups of vertical rods 215, and one end of the compression spring 216 is fixedly connected to the support block 214, and the other end of the compression spring 216 is fixedly connected to the horizontal bar 217, so that the vertical rod 215 can automatically reset after moving. The inner side of the chip bracket 1 is located above several groups of support blocks 214 and is symmetrically equipped with movable grooves 218, and the horizontal bars 217 are slidably connected to the movable grooves 218 to limit the movement of the horizontal bars 217.

[0031] Working principle: Before using this 3D cell culture chip structure, you need to check the overall condition of the device to make sure it can work normally. Figure 1 - Figure 5As shown, positioning components 2 are symmetrically arranged on both sides of several chip bodies 102 inside the chip bracket 1. When the chip body 102 is placed, the two push plates 211 are pushed upward to move, so that the moving rod 209 can be driven to slide inside the positioning sleeve 210. After the moving rod 209 moves, the movable rod 208 can be driven to rotate. After the movable rod 208 rotates, the mounting block 205 can be pushed to move. When the mounting block 205 moves, it drives the fixed sleeve 206 to slide on the support rod 207 to limit the movement of the mounting block 205, thereby driving the sliding rod 203 to move. When the sliding rod 203 moves, the telescopic spring 204 is stretched, so that the positioning block 202 retracts into the sliding groove 201. Then, the limiting rod 2121 between the fixed blocks 212 can be rotated to align the limiting rod 2121 with the limiting groove 213 on the push plate 211. The push plate 211 is released so that the limiting rod 2121 is aligned with the limiting groove 213 on the push plate 211. 1 is engaged with the limiting groove 213, so that the push plate 211 can be limited, and then the chip body 102 is placed on the top of the two horizontal bars 217, so that the top of the chip body 102 is lower than the bottom of the positioning block 202, and then the push plate 211 is slightly pushed upward to disengage the limiting rod 2121 from the limiting groove 213, and the limiting rod 2121 is rotated to release the push plate 211, and the telescopic spring 204 recovers its deformation, so that the positioning block 202 is reset, and then the positioning block 202 blocks the top two sides of the chip body 102, which can limit the chip body 102. When the chip body 102 is removed, the push plate 211 is pushed upward to make the positioning block 202 retract into the sliding groove 201, so that the chip body 102 loses the limit and can be removed. The positioning assembly 2 facilitates the user to place and remove the chip body 102, facilitates the positioning of the chip body 102, and improves the convenience of practicality and practicality;

[0032] When the chip body 102 is placed on the top of the horizontal bar 217, the chip body 102 is pressed down, so that the horizontal bar 217 can be driven to slide in the movable groove 218, and then the vertical rod 215 can be driven to slide on the support block 214, so that the movement of the vertical rod 215 can compress the compression spring 216. When the chip body 102 is taken out, the compression spring 216 can restore its deformation after the chip body 102 loses its limit, and then the horizontal bar 217 can lift the chip body 102, thereby making it convenient for the staff to take the chip body 102, thereby improving practicality.

[0033] Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art may still modify the technical solutions described in the aforementioned embodiments, or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection scope of the present invention.

Claims

1. A 3D cell culture chip structure, comprising a chip support (1) and a chip body (102); A base (101) is fixedly mounted on the bottom of the chip holder (1), and a partition (103) is symmetrically mounted inside the chip holder (1); It is characterized in that Also includes: Positioning components (2) are symmetrically arranged on both sides of a plurality of chip bodies (102) inside the chip support (1); The positioning assembly (2) comprises two groups of sliding grooves (201) symmetrically extending through the upper part of the chip bracket (1) and located on both sides of the chip body (102), and the two groups of sliding grooves (201) are both slidably connected with positioning blocks (202), and two groups of sliding rods (203) are fixedly installed on the sides away from each other of the two groups of positioning blocks (202), and the sliding rods (203) are slidably connected with the sliding grooves (201); The two groups of sliding rods (203) are both sleeved with a telescopic spring (204) on one side of their exteriors, and one end of the telescopic spring (204) is fixedly connected to the chip holder (1), and the other end of the telescopic spring (204) is fixedly installed with a mounting block (205), and the mounting block (205) is fixedly connected to the sliding rod (203), and the tops of the two groups of mounting blocks (205) are both fixedly installed with a fixing sleeve (206), and the interior of the fixing sleeve (206) is slidably connected with a support rod (207), and the support rod (207) is fixedly connected to the chip holder (1).

2. A 3D cell culture chip structure according to claim 1, characterized in that: The bottoms of the two groups of mounting blocks (205) are both hinged with movable rods (208), and one end of the movable rod (208) away from the mounting block (205) is hinged with a moving rod (209), and two groups of push plates (211) are fixedly mounted on the bottoms of the two groups of moving rods (209), respectively.

3. A 3D cell culture chip structure according to claim 2, characterized in that: A positioning sleeve (210) is sleeved on one side of the exterior of the two groups of moving rods (209), and the positioning sleeve (210) is slidably connected to the moving rod (209), and the positioning sleeve (210) is fixedly connected to the chip bracket (1).

4. A 3D cell culture chip structure according to claim 2, characterized in that: The top of the base (101) is located below the plurality of push plates (211) and is symmetrically hinged with a plurality of fixed blocks (212), and a limiting rod (2121) is hinged between the fixed blocks (212), and a limiting groove (213) is provided on one side of the bottom of the push plate (211), and the limiting rod (2121) is snap-fitted and connected with the limiting groove (213).

5. The 3D cell culture chip structure according to claim 1, characterized in that: Two groups of support blocks (214) are symmetrically installed on the inner side of the chip bracket (1) below the plurality of chip bodies (102), and vertical rods (215) are slidably connected inside the two groups of support blocks (214), and two horizontal bars (217) are fixedly installed on the tops of the two groups of vertical rods (215).

6. A 3D cell culture chip structure according to claim 5, characterized in that: A compression spring (216) is sleeved on one side of the exterior of the two groups of vertical rods (215), one end of the compression spring (216) is fixedly connected to the support block (214), and the other end of the compression spring (216) is fixedly connected to the horizontal bar (217).

7. The 3D cell culture chip structure according to claim 5, characterized in that: The inner side of the chip support (1) is symmetrically provided with movable grooves (218) above the plurality of groups of support blocks (214), and the horizontal bars (217) are slidably connected to the movable grooves (218).

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