Full-spectrum imaging system with X-ray and linear scanning functions

Abstract

The utility model discloses a full-spectrum imaging system with X-ray and linear scanning, comprising a camera module which comprises an infrared camera and a visible light camera which are arranged left and right; the objective table is located below the camera module, and the objective table can move in the Z-axis direction and the X-axis direction, so that the objective table can move to the position below the infrared camera or the visible light camera and get close to or away from the camera module; the X-ray instrument is arranged below the objective table and irradiates upwards, and the objective table can move in the X-axis direction, so that the X-ray instrument can move to the position below the infrared camera or the visible light camera; and the flat panel detector is arranged above the objective table, and the flat panel detector can move along the X-axis direction. According to the utility model, the combination and switching of full-spectrum imaging and X-ray imaging are realized.

Description

Technical Field

[0001] The utility model belongs to the technical field of optical imaging, and in particular relates to a full-spectrum imaging system with X-ray and linear scanning. Background Art

[0002] Animal in vivo imaging technology refers to the application of imaging methods to conduct qualitative and quantitative research on biological processes at the tissue, cell and molecular levels in vivo. The principle is to optically label target genes, cells, drug molecules, etc. and inject them into animals, and then use sensitive optical elements (such as CCD) to convert the light signals in the animal into electrical signals, and then convert them into image output. Compared with traditional in vitro imaging or cell culture, this powerful combination of technology platforms provides researchers with fast and effective experimental tools, effectively speeding up the decision-making time of animal experiments, and is the latest research method for studying disease mechanisms and exploring new treatment approaches.

[0003] At present, in vivo optical imaging is mainly divided into bioluminescence imaging (BLI) and fluorescence imaging (FLI). BLI connects the luciferase gene to the downstream of the promoter and stably integrates it into the cell chromosome, so that the luciferase is continuously expressed in the organism, and the substrate is injected to react with the expressed luciferase to emit light. FLI, on the other hand, uses fluorescent reporter genes (such as GFP, RFP) or fluorescent dyes such as Cyt and dyes for labeling, and the fluorescence generated by fluorescent proteins or dyes can form a fluorescent light source in the body.

[0004] In addition, there are many modes of in vivo optical imaging that can achieve multimodal imaging, such as upconversion fluorescence imaging, which is used for upconversion material research and development, biological imaging, anti-tumor drug delivery and photodynamic therapy; X-ray imaging, which is used for direct positioning imaging to better distinguish the internal structure of animals and greatly improve the accuracy of research; Cherenkov luminescence imaging, which is used for the research and development of radioactive tracers and the observation of tumor treatment.

[0005] However, currently, visible light imaging instruments, near-infrared imaging instruments and X-ray imaging instruments are respectively set up independently, which makes it inconvenient for experimenters to switch imaging instruments. Utility Model Content

[0006] The utility model aims to overcome the existing technical defects and provide a full-spectrum imaging system with X-ray and linear scanning, which realizes the combination and switching of full-spectrum imaging and X-ray imaging.

[0007] In order to solve the above technical problems, the utility model provides a full spectrum imaging system with X-ray and linear scanning, including:

[0008] A camera module, wherein the camera module includes an infrared camera and a visible light camera arranged in a left-right arrangement;

[0009] A stage, which is located below the camera module and can move along the Z-axis and X-axis directions, so that the stage can move below the infrared camera or the visible light camera and get close to or away from the camera module;

[0010] An X-ray instrument is disposed below the stage and irradiates upward, and the X-ray instrument can move along the X-axis direction so that the X-ray instrument can move below the infrared camera or the visible light camera;

[0011] The flat panel detector is arranged above the stage and can move along the X-axis direction.

[0012] Furthermore, the full-spectrum imaging system with X-ray and linear scanning also includes a turntable rotatably provided on the X-ray instrument and a stepper motor for driving the turntable to rotate, the turntable is provided with N through holes in a circular array, N is a positive integer greater than 2, and X-ray filters of different thicknesses or different materials are respectively provided at the N-1 through holes, and the turntable is rotated so that different X-ray filters or through holes are located above the emission hole of the X-ray instrument.

[0013] Furthermore, the turntable is provided with six through holes in a circular array, and aluminum sheets and / or copper sheets of different thicknesses are arranged in five of the through holes.

[0014] Furthermore, no X-ray filter is arranged in the first through hole, a high-purity aluminum sheet with a thickness of 0.5 mm is arranged in the second through hole, a high-purity aluminum sheet with a thickness of 1 mm is arranged in the third through hole, a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.06 mm are stacked in the fourth through hole, a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.1 mm are stacked in the fifth through hole, and a high-purity aluminum sheet with a thickness of 0.5 mm, a copper sheet with a thickness of 0.3 mm and a high-purity aluminum sheet with a thickness of 0.5 mm are stacked in sequence in the sixth through hole.

[0015] Furthermore, the full-spectrum imaging system with X-ray and linear scanning also includes a horizontal driving table for driving the X-ray instrument to move along the X-axis direction, the horizontal driving table includes a table top, a first horizontal guide rail arranged on the table top, a first lead screw rotatably arranged on the first horizontal guide rail, and a first motor connected to one end of the first lead screw, a first slider is slidably provided on the first horizontal guide rail, a first lead screw nut is provided on the first lead screw, and the bottom of the X-ray instrument is connected to the first slider and the first lead screw nut.

[0016] Furthermore, the horizontal driving platform also includes a guide rod rotatably arranged on the platform and arranged parallel to the first horizontal guide rail, a second slider is arranged on the guide rod, and the bottom of the X-ray device is fixed to the second slider.

[0017] Furthermore, the full-spectrum imaging system with X-ray and linear scanning also includes a movable slide for driving the flat-panel detector to move along the X-axis direction, the movable slide includes a second horizontal guide rail, a second lead screw rotatably arranged on the second horizontal guide rail, and a second motor transmission-connected to one end of the second lead screw, a third slider is slidably arranged on the second horizontal guide rail, a second lead screw nut is arranged on the second lead screw, and one end of the flat-panel detector is connected to the third slider and the second lead screw nut.

[0018] Furthermore, one end of the flat-panel detector is connected to the third slider and the second lead screw nut through a first suspension rod; the movable slide also includes a sliding shaft arranged parallel to the second horizontal guide rail, and the other end of the flat-panel detector is slidably arranged on the sliding shaft through a second suspension rod, and the upper end of the second suspension rod is provided with at least one sliding bearing rolling on the sliding shaft.

[0019] Furthermore, travel switches are provided on both sides of the flat-panel detector.

[0020] Furthermore, the full-spectrum imaging system with X-ray and linear scanning also includes a horizontal moving device for driving the stage to move along the X-axis direction and a vertical moving device for driving the stage and the horizontal moving device to move along the Z-axis direction.

[0021] The utility model has the following beneficial effects:

[0022] In the utility model, an infrared camera and a visible light camera are provided at the same time, and cooperate with a movable stage, so that the stage can be moved to the bottom of the infrared camera and the visible light camera, respectively, to realize infrared imaging and visible light imaging of the object placed on the stage, that is, to realize the combination and switching of infrared imaging and visible light imaging; the utility model also provides a movable X-ray instrument, which can be respectively cooperated with a flat-panel detector, an infrared camera or a visible light camera for imaging, thereby realizing the combination and switching of X-ray imaging, infrared imaging and visible light imaging; and has the characteristics of simple overall structure and convenient operation.

[0023] Additional aspects and advantages of the present invention will be partially given in the following description, which will become apparent from the following description or be understood through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The drawings described herein are used to provide a further understanding of the present invention, constitute a part of the present application, and do not constitute an improper limitation of the present invention. In the drawings:

[0025] Figure 1 is a schematic diagram of a full-spectrum imaging system in an embodiment;

[0026] Figure 2 This is a schematic diagram of the full-spectrum imaging system in the embodiment after the box is removed;

[0027] Figure 3 for Figure 2 The front view in;

[0028] Figure 4 It is a schematic diagram of the X-ray apparatus and the horizontal moving stage after being assembled in the embodiment;

[0029] Figure 5 This is a schematic diagram of the flat panel detector and the movable slide after being assembled in the embodiment;

[0030] Figure 6 Schematic diagram of the assembly of the loading platform, the horizontal moving device and the vertical moving device in the embodiment. DETAILED DESCRIPTION

[0031] In order to more fully understand the technical content of the present invention, the present invention will be further introduced and explained in conjunction with the accompanying drawings and specific embodiments below; it should be noted that descriptions such as "first" and "second" in the text are used to distinguish different components, etc., and do not represent the order of precedence, nor do they limit the "first" and "second" to different types.

[0032] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments; based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the utility model.

[0033] Example

[0034] like Figures 1 to 6 As shown, the full-spectrum imaging system with X-ray and linear scanning shown in this embodiment includes a box 100, a camera module arranged on the top of the box 100, and a stage 1, an X-ray instrument 2 and a flat-panel detector 3 arranged in the box 100. The camera module includes an infrared camera 4 and a visible light camera 5 arranged in a left-right arrangement; the stage 1 is located below the camera module, and the stage 1 can move along the Z-axis and X-axis directions, so that the stage 1 can move to the bottom of the infrared camera 4 or the visible light camera 5 and approach or move away from the camera module, that is, according to the selected imaging mode, the stage 1 is driven to move to the bottom of the corresponding camera, and the field of view during imaging is adjusted by moving the stage 1 up and down; the X-ray instrument 2 is located below the stage 1 and illuminates upward. The X-ray apparatus 2 can be moved along the X-axis direction so that the X-ray apparatus 2 can be moved to the bottom of the infrared camera 4 or the visible light camera 5; the flat-panel detector 3 is arranged above the stage 1, and the flat-panel detector 3 can be moved along the X-axis direction so that the flat-panel detector 3 cooperates with the X-ray apparatus to complete linear scanning during the movement to obtain an X-ray image, that is, by utilizing the relationship that the flat-panel detector 3, the stage 1 and the X-ray apparatus 2 can all be moved along the X-axis, the X-ray apparatus and the stage can be synchronously moved to a position below the infrared camera, the visible light camera or the flat-panel detector, and the X-ray apparatus 2 emits X-rays and passes upward through the imaging object placed on the stage, and finally reaches the infrared camera, the visible light camera or the flat-panel detector for imaging.

[0035] In the above, an infrared camera and a visible light camera are provided at the same time, and cooperate with a movable stage so that the stage can be moved to the bottom of the infrared camera and the visible light camera, respectively, to realize infrared imaging and visible light imaging of the object placed on the stage, that is, to realize the combination and switching of infrared imaging and visible light imaging; the utility model also provides a movable X-ray device, which can be respectively cooperated with a flat-panel detector, an infrared camera or a visible light camera for imaging, thereby realizing the combination and switching of X-ray imaging with infrared imaging and visible light imaging; there are five imaging modes in total, specifically: 1. Visible light imaging is realized by using a single visible light camera; 2. Infrared imaging is realized by using a single infrared camera; 3. Imaging is realized by cooperating between the X-ray device and the flat-panel detector; 4. Imaging is realized by cooperating between the X-ray device and the visible light camera; 5. Imaging is realized by cooperating between the X-ray device and the infrared camera.

[0036] In another embodiment, as shown in the figure, a first light source module 41 is provided at the lower end of the infrared camera 4 for irradiating downward and surrounding the infrared camera; a second light source module 51 is provided at the lower end of the visible light camera 5 for irradiating downward and surrounding the visible light camera.

[0037] In one embodiment, if Figure 4 As shown, the full-spectrum imaging system also includes a turntable 21 rotatably arranged on the upper end of the X-ray instrument 2 and a stepper motor 22 for driving the turntable 21 to rotate. The turntable 21 is provided with N through holes 23 in a circular array, N is a positive integer greater than 2, and N-1 through holes are respectively provided with X-ray filters 24 of different thicknesses or different materials. By rotating the turntable 21 so that different X-ray filters 24 or through holes 23 are located above the emission hole of the X-ray instrument 2, according to the imaging conditions required for different imaging objects, the corresponding X-ray filter 24 on the turntable is selected to filter the X-rays or the through holes are used not to filter the X-rays.

[0038] Preferably, a driving gear 25 is provided on the rotating shaft of the stepping motor 22 , and gear teeth meshing with the driving gear 25 are provided on the outer periphery of the turntable 21 .

[0039] In one embodiment, if Figure 4 As shown, six through holes 23 are provided on the turntable 21 in a circular array; wherein, the first through hole is not provided with an X-ray filter, and maintains a through hole shape, and is used for low-voltage, low-contrast sample imaging; a high-purity aluminum sheet with a thickness of 0.5 mm is provided in the second through hole, and is used for low-contrast sample imaging; a high-purity aluminum sheet with a thickness of 1 mm is provided in the third through hole, and is used for soft tissue (fat analysis) sample imaging; a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.06 mm are stacked up and down in the fourth through hole, and are used for standard scanning; a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.1 mm are stacked up and down in the fifth through hole, and are used for high-voltage, high-density sample imaging; a high-purity aluminum sheet with a thickness of 0.5 mm, a copper sheet with a thickness of 0.3 mm, and a high-purity aluminum sheet with a thickness of 0.5 mm are stacked up and down in the sixth through hole.

[0040] In one embodiment, if Figure 4As shown, the full-spectrum imaging system also includes a horizontal driving table 6 for driving the X-ray device 2 to move along the X-axis direction. The horizontal driving table includes a table top 61 fixed in the box 100, a first horizontal guide rail 62 arranged on the table top 61, a first lead screw 63 rotatably arranged on the first horizontal guide rail 62, and a first motor 68 drivingly connected to one end of the first lead screw 63. A first slider 65 is slidably provided on the first horizontal guide rail 62, and a matching first lead screw nut 64 is provided on the first lead screw 63. The bottom of the X-ray device 2 is connected to the first slider 65 and the first lead screw nut 64. The first motor 68 is used to drive the first lead screw nut 64, the first slider 65 and the X-ray device 2 to move back and forth along the first horizontal guide rail 62.

[0041] As a preference, Figure 4 As shown, the horizontal driving table 6 also includes a guide rod 66 rotatably arranged on the table top 61 and arranged parallel to the first horizontal guide rail 62. A second slider 67 is provided on the guide rod 66. The bottom of the X-ray device 2 is fixed to the second slider 67, thereby forming a double-point fixing method to improve the stability of the X-ray device 2 when sliding.

[0042] In one embodiment, if Figure 5 As shown, the full-spectrum imaging system also includes a movable slide 7 for driving the flat-panel detector 3 to move along the X-axis direction. The movable slide includes a second horizontal guide rail 71, a second lead screw 72 rotatably arranged on the second horizontal guide rail 71, and a second motor 79 drivingly connected to one end of the second lead screw 72. A third slider 73 is slidably arranged on the second horizontal guide rail 71, and a matching second lead screw nut 74 is arranged on the second lead screw 72. One end of the flat-panel detector 3 is connected to the third slider 73 and the second lead screw nut 74, so that the movable slide 7 is used to drive the flat-panel detector 2 to move forward and backward along the second horizontal guide rail 71.

[0043] In one embodiment, if Figure 5 As shown, one end of the flat-panel detector 3 is connected to the third slider 73 and the second lead screw nut 74 through the first suspension rod 75; the movable slide 7 also includes a sliding shaft 76 suspended on the top of the inner side of the box body and arranged parallel to the second horizontal guide rail 71. The other end of the flat-panel detector 2 is slidably arranged on the sliding shaft 76 through the second suspension rod 77, forming a stable sliding structure with both ends suspended. The upper end of the second suspension rod 77 is provided with at least one sliding bearing 78 rollingly arranged on the sliding shaft 76. The second horizontal guide rail 71 and the sliding shaft 76 are respectively arranged on the front and rear sides of the visible light camera 5, and the hanging effect of the two suspension rods is used to make the flat-panel detector 2 be arranged below the visible light camera 5, so that the flat-panel detector 2 can be dislocated or overlapped with the shooting hole of the visible light camera during the movement of the flat-panel detector 2.

[0044] In one embodiment, if Figure 6As shown, the full-spectrum imaging system further includes a horizontal moving device 11 for driving the stage 1 to move along the X-axis direction and a vertical moving device 12 for driving the stage 1 and the horizontal moving device 11 to move along the Z-axis direction.

[0045] In one embodiment, travel switches 31 are provided on both sides of the flat panel detector 3 to prevent it from hitting the box 100 and the vertical moving device 12 during movement.

[0046] In other embodiments, both the vertical moving device and the horizontal moving device may adopt a screw drive mechanism, and may also adopt a belt drive mechanism or a cylinder drive mechanism, etc. The screw drive mechanism, the belt drive mechanism and the cylinder drive mechanism are all conventional drive mechanisms.

[0047] In other embodiments, a lead sheet is provided on the outer wall or the inner wall of the box body to wrap it, so as to achieve radiation shielding when the X-ray device is working.

[0048] In other embodiments, the infrared imaging of the infrared camera includes near infrared zone 1 imaging and near infrared zone 2 imaging. The spectrum of near infrared zone 1 imaging is 700-900nm, and the spectrum of near infrared zone 2 imaging is 1000-1700nm.

[0049] In other embodiments, the spectrum of visible light imaging of the visible light camera is 400-700 nm.

[0050] The technical solutions provided by the embodiments of the present invention are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the embodiments of the present invention. The description of the above embodiments is only applicable to help understand the principles of the embodiments of the present invention. At the same time, for those skilled in the art, according to the embodiments of the present invention, there will be changes in the specific implementation methods and application scopes. In summary, the content of this specification should not be understood as a limitation on the present invention.

Claims

1. A full spectrum imaging system with X-ray and linear scanning, characterized in that: include: A camera module, wherein the camera module includes an infrared camera and a visible light camera arranged in a left-right arrangement; A stage, which is located below the camera module and can move along the Z-axis and X-axis directions, so that the stage can move below the infrared camera or the visible light camera and get close to or away from the camera module; An X-ray instrument is disposed below the stage and irradiates upward, and the X-ray instrument can move along the X-axis direction so that the X-ray instrument can move below the infrared camera or the visible light camera; The flat panel detector is arranged above the stage and can move along the X-axis direction.

2. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 1, characterized in that: It also includes a turntable that is rotatable on the X-ray instrument and a stepper motor for driving the turntable to rotate, the turntable is provided with N through holes in a circular array, N is a positive integer greater than 2, and X-ray filters of different thicknesses or different materials are respectively provided at the N-1 through holes, and the turntable is rotated so that different X-ray filters or through holes are located above the emission hole of the X-ray instrument.

3. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 2, characterized in that: The turntable is provided with six through holes in a circular array, wherein aluminum sheets and / or copper sheets of different thicknesses are arranged in five of the through holes.

4. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 3, characterized in that: No X-ray filter is set in the first through hole, a high-purity aluminum sheet with a thickness of 0.5 mm is set in the second through hole, a high-purity aluminum sheet with a thickness of 1 mm is set in the third through hole, a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.06 mm are stacked in the fourth through hole, a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.1 mm are stacked in the fifth through hole, and a high-purity aluminum sheet with a thickness of 0.5 mm, a copper sheet with a thickness of 0.3 mm and a high-purity aluminum sheet with a thickness of 0.5 mm is stacked in sequence in the sixth through hole.

5. The full spectrum imaging system with X-ray and linear scanning according to any one of claims 1 to 4, characterized in that: It also includes a horizontal driving table for driving the X-ray device to move along the X-axis direction, the horizontal driving table includes a table top, a first horizontal guide rail arranged on the table top, a first lead screw rotatably arranged on the first horizontal guide rail, and a first motor connected to one end of the first lead screw, a first slider is slidably arranged on the first horizontal guide rail, a first lead screw nut is arranged on the first lead screw, and the bottom of the X-ray device is connected to the first slider and the first lead screw nut.

6. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 5, characterized in that: The horizontal driving platform also includes a guide rod rotatably arranged on the platform and arranged parallel to the first horizontal guide rail, a second slider is arranged on the guide rod, and the bottom of the X-ray device is fixed to the second slider.

7. The full spectrum imaging system with X-ray and linear scanning according to any one of claims 1 to 4, characterized in that: It also includes a movable slide for driving the flat-panel detector to move along the X-axis direction, the movable slide includes a second horizontal guide rail, a second lead screw rotatably arranged on the second horizontal guide rail, and a second motor transmission-connected to one end of the second lead screw, a third slider is slidably arranged on the second horizontal guide rail, a second lead screw nut is arranged on the second lead screw, and one end of the flat-panel detector is connected to the third slider and the second lead screw nut.

8. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 7, characterized in that: One end of the flat-panel detector is connected to the third slider and the second lead screw nut via a first suspension rod; the movable slide also includes a sliding shaft arranged parallel to the second horizontal guide rail, and the other end of the flat-panel detector is slidably arranged on the sliding shaft via a second suspension rod, and the upper end of the second suspension rod is provided with at least one sliding bearing rolling on the sliding shaft.

9. The full spectrum imaging system with X-ray and linear scanning as claimed in claim 8, characterized in that: Travel switches are arranged on both sides of the flat panel detector.

10. The full spectrum imaging system with X-ray and linear scanning according to any one of claims 1 to 4, characterized in that: It also includes a horizontal moving device for driving the stage to move along the X-axis direction and a vertical moving device for driving the stage and the horizontal moving device to move along the Z-axis direction.

Images