Coronary artery thrombolysis device for acute myocardial infarction

Abstract

The utility model relates to the technical field of medical instruments, and discloses an intracoronary thrombolysis device for acute myocardial infarction, which comprises a drug delivery system, a positioning system and a guide system, the dosing system comprises a dosing tube, and a dosing hole is formed in the far end of the dosing tube; the positioning system comprises an air delivery pipe and a pre-expanded balloon, the air delivery pipe is arranged in the drug delivery pipe, and the pre-expanded balloon is arranged at the far end of the air delivery pipe; the guide system comprises a guide tube and a drainage head, the guide tube is arranged in the air delivery tube, and the drainage head is arranged at the far end of the guide tube; when the coronary artery thrombolysis device is used, the drug delivery system, the positioning system and the guiding system are arranged, so that the device can accurately inject thrombolysis drugs at the thrombus position in the coronary artery of a patient, accurate treatment on the thrombus in the coronary artery of acute myocardial infarction is achieved, the operation time can be effectively saved, operation is convenient, and operation is easy. The problems that according to an existing thrombolysis device, in-vivo open treatment needs to be carried out, thrombus positioning and accurate perfusion of thrombolysis medicine in the coronary artery are difficult to achieve, and the like are effectively solved.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and in particular relates to an intracoronary thrombolytic device for acute myocardial infarction. Background Art

[0002] Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia of the coronary arteries. After the formation of thrombus inside the blood vessels, the flow of blood inside the blood vessels is blocked, which can easily cause blood supply difficulties in patients with acute myocardial infarction, thereby causing shock, heart failure and other problems. The existing methods for treating acute myocardial infarction mainly include intravenous thrombolysis, percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), etc. Among them, even if thrombus aspiration is used during PCI, there are still a large number of microthrombi that cannot be removed by mechanical treatment methods; CABG in the acute phase of MI has a high risk and large surgical trauma; therefore, compared with the above two methods, intravenous thrombolysis, as a non-invasive treatment method, has gradually occupied an important position in the current treatment of acute myocardial infarction.

[0003] The key to intravenous thrombolytic therapy is to use the perfusion thrombolytic catheter to deliver the intravenous thrombolytic drug to the designated location in the shortest possible time, and then use the drug to open the blocked coronary artery and restore myocardial perfusion. After searching, patent No. CN217014144U discloses an intracoronary thrombolytic device for acute myocardial infarction. The device, through the setting of the thrombolytic component, cooperates with the set film and micro-scales, under the weaving effect of the braided wire, can make the entire thrombolytic component better handle the thrombus during the treatment process, solving the problem that the existing thrombolytic device can handle most of the thrombi by digging and rotating during use, but during use, due to the thin inner wall of the artery, the vascular wall is easily damaged during the process of digging and rotating to remove the thrombus. At the same time, when removing the thrombus, the thrombus is not removed thoroughly, resulting in poor treatment effect; but the device has the following problems when in use:

[0004] 1. During the thrombolytic treatment, the device uses micro-scales to segment the thrombus to remove it; this is a surgical treatment, and there is a creative wound on the blood vessel wall. The blood vessel wall is located in the human body, which is not convenient for hemostasis;

[0005] 2. In the process of removing blood clots using the above-mentioned device, since the action of the micro-scales is to segment the blood clots, it is easy to cause the patient's blood vessels to twitch or tighten due to stress perception of pain. Therefore, the healthy blood vessel walls are easily scratched during the activity of the micro-scales, making it difficult to effectively achieve positioning and directional treatment.

[0006] Therefore, the utility model proposes an intracoronary thrombolytic device for acute myocardial infarction to solve the problems existing in the above-mentioned prior art. Utility Model Content

[0007] 1. Technical issues to be resolved

[0008] In view of the deficiencies in the prior art, the utility model provides an intracoronary thrombolytic device for acute myocardial infarction, which has the advantages of being able to locate and perfuse thrombolytic drugs, simple operation, time saving, and realizing non-invasive treatment of intracoronary thrombolysis, precise perfusion of thrombolytic drugs within the coronary artery, and good effect of thrombus removal. It solves the problems of existing thrombolytic devices, such as the need for open treatment in the body, difficulty in effectively locating thrombi and precise perfusion of thrombolytic drugs within the coronary artery, and the like.

[0009] (II) Technical solution

[0010] In order to achieve the above-mentioned purpose of being able to positionally perfuse thrombolytic drugs, realize non-invasive treatment of intracoronary thrombolysis and achieve good thrombus removal effect, the utility model provides the following technical solutions:

[0011] A device for intracoronary thrombolysis for acute myocardial infarction comprises a drug delivery system, a positioning system and a guiding system used in conjunction with each other; the drug delivery system is used for targeted drug delivery at a thrombus in a coronary artery when in use, comprises a drug delivery tube, and a plurality of drug delivery holes penetrating the side wall of the drug delivery tube are provided at the distal end of the drug delivery tube, for targeted drug delivery to the thrombus at the positioning location using the drug delivery holes; the positioning system comprises an air delivery tube and a pre-expansion balloon, the air delivery tube is fixedly arranged in the drug delivery tube, a drug delivery cavity is formed between the air delivery tube and the drug delivery tube and is connected to the drug delivery hole, the pre-expansion balloon is arranged at the distal end of the air delivery tube, and is used for inflating the pre-expansion balloon when in use to expand the stenosis and thrombus in the coronary artery, so that the drug delivery hole is positioned at the thrombus position in the patient's coronary artery, and precise drug delivery is performed; the guiding system comprises a guide tube, the guide tube is fixedly arranged in the air delivery tube, and a pressurized cavity is formed between the guide tube and the air delivery tube.

[0012] Preferably, the guide system also includes a drainage head, which is detachably mounted on the distal end of the guide tube, and includes a protective shell and a baffle shell that cooperate with each other; the protective shell is a hemispherical shell structure that is detachably mounted on the distal end of the guide tube, and a plurality of first flow guide holes are arranged on the protective shell; the baffle shell is rotatably mounted in the protective shell through a connecting sleeve arranged in the protective shell, and a plurality of second flow guide holes are arranged on the baffle shell for use in conjunction with the first flow guide holes, and the positional relationship between the first flow guide holes and the second flow guide holes can be adjusted by rotating the baffle shell during use.

[0013] Preferably, a connecting frame is further provided in the baffle shell, and the connecting frame is used in conjunction with the guide wire. When in use, the connecting frame is connected to the guide wire through the baffle shell, and the guide wire is rotated to change the positional relationship between the first guide hole and the second guide hole.

[0014] Preferably, a dosing connecting tube is provided at the proximal end of the dosing tube and is connected to the dosing tube, and the dosing hole is connected to the dosing cavity, so that when in use, a dosing device is connected to the dosing connecting tube and the dosing cavity and the dosing hole are used to administer the drug to the patient's thrombosis site.

[0015] Preferably, a plurality of pressurized holes are provided on the distal side wall of the gas supply tube and are connected to the pre-expansion balloon to realize the connection between the pressurized cavity and the pre-expansion balloon; and a pressurized connecting tube is provided at the proximal end of the gas supply tube. When in use, a pressurized pump is connected to the pressurized connecting tube to control the pressure in the pre-expansion balloon to expand the stenosis and thrombus in the distal coronary artery of the device, and to perform positioning in the coronary artery.

[0016] Preferably, a connecting tube is further provided at the distal end of the guide tube, which is used to introduce the guide wire into the internal cavity of the guide tube through the connecting tube when in use.

[0017] Preferably, the length of the drug delivery tube is shorter than the length of the air delivery tube, and the length of the air delivery tube is shorter than the length of the guide tube.

[0018] (III) Beneficial effects

[0019] Compared with the prior art, the utility model provides a coronary artery thrombolytic device for acute myocardial infarction, which has the following beneficial effects:

[0020] The utility model designs a coronary artery thrombolytic device for acute myocardial infarction, which includes a drug delivery system, a positioning system and a guiding system that cooperate with each other. When in use:

[0021] 1. Through the setting of drug delivery system, positioning system and guidance system, the device can accurately infuse thrombolytic drugs at the location of thrombus in the patient's coronary artery. It integrates pre-expansion balloon and infusion catheter, which can effectively save operation time and is more convenient. It can accurately infuse thrombolytic drugs in the coronary artery; it can achieve accurate treatment of thrombus in the coronary artery of acute myocardial infarction, relieve the pain of patients and will not cause damage to the blood vessel wall, and effectively solve the problems of existing thrombolytic devices, such as the need for open treatment in the body, difficulty in effectively locating thrombus and accurately infusing thrombolytic drugs in the coronary artery;

[0022] 2. By setting up the drainage head, the positional relationship between the first guide hole and the second guide hole can be adjusted according to the needs of the patient during the treatment process, so as to remove the adhesion mucus on the patient's thrombus or the free abscess material produced, thereby ensuring the treatment effect on the patient, and achieving the purpose of localized perfusion of thrombolytic drugs, realizing non-invasive treatment of intracoronary thrombolysis and good thrombus removal effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the structure of the intracoronary thrombolytic device of the utility model;

[0024] Figure 2 It is a schematic diagram of the structure of the drug delivery system of the utility model;

[0025] Figure 3 It is a structural schematic diagram of the positioning system of the utility model;

[0026] Figure 4 It is a structural schematic diagram of the guidance system of the utility model;

[0027] Figure 5 It is a cross-sectional view of the intracoronary thrombolytic device of the utility model;

[0028] Figure 6 It is a partial enlarged view of the A part of the intracoronary thrombolytic device of the utility model;

[0029] Figure 7 It is a partial enlarged view of the B part of the intracoronary thrombolytic device of the utility model;

[0030] Figure 8 It is a structural schematic diagram of the drainage head of the utility model.

[0031] In the figure: 1. drug delivery system, 11. drug delivery tube, 12. drug delivery connecting tube, 13. drug delivery hole, 14. drug delivery cavity, 2. positioning system, 21. air delivery tube, 22. pressurization connecting tube, 23. pre-expansion balloon, 24. pressurization hole, 25. limit plate, 26. pressurization cavity, 3. guide system, 31. guide tube, 32. connecting tube, 33. drainage head, 331. protective shell, 332. flow blocking shell, 333. connecting sleeve, 334. connecting frame, 335. first guide hole, 336. second guide hole, 34. guide cavity. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0033] Example 1: Please refer to Figure 1-8 The utility model provides a technical solution: an intracoronary thrombolytic device for acute myocardial infarction, comprising a drug delivery system 1, a positioning system 2 and a guiding system 3 that cooperate with each other;

[0034] The drug delivery system 1 is used for targeted drug delivery at a thrombus in a coronary artery when in use, and comprises a drug delivery tube 11, and a plurality of drug delivery holes 13 penetrating the side wall of the drug delivery tube are arranged at the distal end of the drug delivery tube 11. When in use, the drug delivery holes 13 are used to deliver drug to the thrombus at the location;

[0035] The positioning system 2 includes an air delivery tube 21 and a pre-expansion balloon 23. The air delivery tube 21 is fixedly arranged in the drug delivery tube 11. A drug delivery cavity 14 is formed between the air delivery tube 21 and the drug delivery tube 11 and communicates with the drug delivery hole 13. The pre-expansion balloon 23 is arranged at the distal end of the air delivery tube 21 and is used to expand the stenosis and thrombus in the coronary artery by inflating the pre-expansion balloon 23 when in use, and at the same time, the drug delivery hole 13 is positioned at the thrombus position in the patient's coronary artery for precise drug delivery.

[0036] The guide system 3 includes a guide tube 31 and a drainage head 33. The guide tube 31 is fixedly arranged in the air supply tube 21 to form a pressurized chamber 26 between the guide tube 31 and the air supply tube 21. The drainage head 33 is detachably arranged at the distal end of the guide tube 31 to remove the adherent mucus on the thrombus or the free abscess material generated as needed during drug administration.

[0037] As a preferred embodiment, Figure 2 and Figure 6 As shown, in order to locate and administer medication to the patient's thrombus through the medication hole 13 and the medication cavity 14 when in use, a medication connecting tube 12 is also provided at the proximal end of the medication tube 11 to communicate with the medication tube 11, and the medication hole 13 is communicated with the medication cavity 14, so that when in use, a medication dispenser is connected to the medication connecting tube 12, and medication is administered to the patient's thrombus through the medication cavity 14 and the medication hole 13.

[0038] As a preferred embodiment, Figure 3 and Figure 6As shown, in order to connect the distal end of the pressurizing chamber 26 with the pre-expansion balloon 23 when in use, a plurality of pressurizing holes 24 are provided on the distal side wall of the gas supply tube 21 to connect with the pre-expansion balloon 23, so as to realize the connection between the pressurizing chamber 26 and the pre-expansion balloon 23; and a pressurizing connecting tube 22 is provided at the proximal end of the gas supply tube 21. When in use, a pressurizing pump is connected to the pressurizing connecting tube 22 to control the pressure in the pre-expansion balloon 23 to expand the stenosis and thrombus in the distal coronary artery of the device, and to position it in the coronary artery.

[0039] As a preferred embodiment, Figure 4 , Figure 6 and Figure 7 As shown, in order to facilitate the insertion of the guide wire into the guide tube 31 during use, a connecting tube 32 is further provided at the distal end of the guide tube 31 for guiding the guide wire into the internal cavity of the guide tube 31 through the connecting tube during use.

[0040] As a preferred embodiment, Figure 1 As shown, for ease of installation and use, the length of the drug delivery tube is shorter than the length of the air delivery tube 21 , and the length of the air delivery tube 21 is shorter than the length of the guide tube 31 .

[0041] As a preferred embodiment, in order to facilitate the limiting of the pre-expansion balloon 23 , a limiting disk 25 is further provided at the distal end of the gas delivery tube 21 .

[0042] As a preferred embodiment, the various types of catheters are formed by connecting pipes of different shapes and structures by hot melt welding, laser welding and / or bonding, and the drug delivery tube 11, air delivery tube 21 and guide tube 31 are all made of any one of VC, PC, Pebax, Nylon, PU, ​​TPU, PE, PTFE materials or a combination thereof.

[0043] Example 2: Please refer to Figure 7 and Figure 8 In order to remove the adherent mucus on the patient's thrombus or the free abscess material generated after the localized thrombolytic therapy, the drainage head 33 is designed to be detachably mounted on the distal end of the guide tube 31, including a protective shell 331 and a flow-blocking shell 332 used in conjunction with each other, wherein

[0044] The protective shell 331 is a hemispherical structure detachably mounted on the distal end of the guide tube 31, and a plurality of first guide holes 335 are provided on the protective shell 331;

[0045] The baffle shell 332 is rotatably installed in the protective shell 331 through a connecting sleeve 333 arranged in the protective shell 331, and a plurality of second guide holes 336 are arranged on the baffle shell 332 for use with the first guide holes 335, that is, when in use, the positional relationship between the first guide holes 335 and the second guide holes 336 is adjusted by rotating the baffle shell 332 to achieve flow through and flow cutoff.

[0046] As a preferred embodiment, in order to facilitate the rotation of the baffle shell 332 by guiding the guide wire, a connecting frame 334 is also provided in the baffle shell 332. The connecting frame 334 is used in conjunction with the guide wire. When in use, the baffle shell 332 is connected to the guide wire. Rotating the guide wire changes the positional relationship between the first guide hole 335 and the second guide hole 336.

[0047] When using the intracoronary thrombolytic device for acute myocardial infarction described in the utility model: first, the guide wire is inserted into the guide tube 31, and then the device is sent into the patient's coronary artery. After the drug delivery area of ​​the drug delivery system 1 reaches the target position; a pressure pump is installed to control the pressure in the pre-expansion balloon 23 to position the distal end of the device in the coronary artery; and after the positioning is completed, a drug delivery device is connected to the drug delivery connecting tube 12, and the drug is delivered to the patient's thrombus through the drug delivery cavity 14 and the drug delivery hole 13, and the drug powder is sprayed on the patient's thrombus to perform positioned thrombolytic treatment; the positional relationship between the first guide hole 335 and the second guide hole 336 is adjusted by rotating the guide wire as needed, so as to facilitate the removal of adhesion mucus on the patient's thrombus or the free abscess material generated.

[0048] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0049] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An intracoronary thrombolytic device for acute myocardial infarction, characterized in that: It comprises a matching drug delivery system (1), a positioning system (2) and a guiding system (3); The drug delivery system (1) comprises a drug delivery tube (11), wherein a plurality of drug delivery holes (13) are arranged at the distal end of the drug delivery tube (11); The positioning system (2) comprises an air delivery tube (21) and a pre-expansion balloon (23), wherein the air delivery tube (21) is arranged in the drug delivery tube (11), a drug delivery cavity (14) is formed between the air delivery tube (21) and the drug delivery tube (11), and the pre-expansion balloon (23) is arranged at the distal end of the air delivery tube (21); The guide system (3) comprises a guide tube (31), wherein the guide tube (31) is arranged in the gas delivery tube (21), and a pressurized chamber (26) is formed between the guide tube (31) and the gas delivery tube (21).

2. The intracoronary thrombolytic device for acute myocardial infarction according to claim 1, characterized in that: The guide system (3) further comprises a drainage head (33), which is detachably arranged at the distal end of the guide tube (31) and comprises a protective shell (331) and a flow blocking shell (332); The protective shell (331) is a hemispherical shell-shaped structure that is detachably arranged at the distal end of the guide tube (31), and a plurality of first flow guide holes (335) are arranged on the protective shell (331); The baffle shell (332) is arranged in the protective shell (331) by rotation, and a plurality of second flow guide holes (336) are arranged on the baffle shell (332) to match the first flow guide holes (335).

3. The intracoronary thrombolytic device for acute myocardial infarction according to claim 2, characterized in that: A connecting frame (334) is also provided in the baffle shell (332), and the connecting frame (334) is adapted to the guide wire.

4. The intracoronary thrombolytic device for acute myocardial infarction according to claim 2, characterized in that: A connecting sleeve (333) is arranged inside the protective shell (331), and the connecting sleeve (333) is adapted to the flow-blocking shell (332).

5. The intracoronary thrombolytic device for acute myocardial infarction according to claim 1, characterized in that: A medication connection tube (12) is also provided at the proximal end of the medication tube (11), and the medication connection tube (12) is connected to the medication tube (11).

6. The intracoronary thrombolytic device for acute myocardial infarction according to claim 1, characterized in that: A plurality of pressurizing holes (24) are also provided on the distal side wall of the gas delivery tube (21) and are connected to the pre-expansion balloon (23).

7. The intracoronary thrombolytic device for acute myocardial infarction according to claim 1, characterized in that: The proximal end of the gas delivery pipe (21) is also provided with a pressurizing connecting pipe (22) which is in communication with the gas delivery pipe (21).

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