Biopharmaceutical drying granulator

Abstract

The utility model discloses a drying granulator for biopharmacy. The drying granulator comprises a main body frame, a speed reducer, a granulating pipe, a spiral extrusion shaft and a drying bin, a main driving motor is fixedly installed on the rear side of the lower end of the main body frame, a first belt wheel is fixedly installed on a transmission shaft part at the rear end of the main driving motor, the first belt wheel is in transmission connection with a second belt wheel through a transmission belt, and an extrusion hole disc is fixedly installed on the inner wall of the front end of the granulation pipe; a granulation disc is fixedly mounted in the middle of the front end of the granulation pipe, a granulation hole is formed in the middle of the granulation disc, an extrusion cone is fixedly mounted in the middle of the rear end of the granulation disc, and a feeding groove is fixedly formed in the upper side of the rear end of the granulation pipe in a penetrating manner; and a heater is fixedly mounted on the outer side wall of the drying bin. According to the device, medicine particles are prepared, and meanwhile, medicine raw materials can be pre-dried before the medicine raw materials are prepared into the particles.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, in particular to a biopharmaceutical drying and granulating machine. Background Art

[0002] Biopharmaceuticals refer to a type of products used for prevention, treatment and diagnosis that are manufactured from organisms, biological tissues, cells, organs, body fluids, etc., using the research results of microbiology, biology, medicine, biochemistry, etc., and comprehensively utilizing the scientific principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy, etc. Biopharmaceutical raw materials are mainly natural biological materials, including microorganisms, human bodies, animals, plants, marine organisms, etc. With the development of biotechnology, purposefully artificially produced biological raw materials have become the main source of current biopharmaceutical raw materials.

[0003] In the field of biopharmaceuticals, drying and granulation equipment is used to prepare drug particles, and the particle preparation process has an important influence on the solubility, stability, bioavailability and other properties of the drug.

[0004] However, when the prior art is actually used, in the process of preparing drug particles, conventional drying and granulating equipment usually dries the discharged drug particles after the drug raw materials are prepared into particles. However, when the discharged drug particles are dried after the drug raw materials are prepared into particles, the drug particles are not completely solidified, which may easily lead to the stickiness of the drug particles, thereby affecting the preparation effect of the drug particles and failing to meet the demand for high-quality particles in the biopharmaceutical industry. Utility Model Content

[0005] The utility model aims to provide a biopharmaceutical drying granulator to solve the problem that the traditional drying granulator proposed in the above-mentioned background technology usually dries the discharged drug particles after the drug raw materials are prepared into particles, but when the discharged drug particles are dried after the drug raw materials are prepared into particles, the drug particles are not completely solidified, which easily leads to the stickiness of the drug particles, thereby affecting the preparation effect of the drug particles and failing to meet the demand for high-quality particles in the biopharmaceutical industry.

[0006] In order to achieve the above-mentioned purpose, the utility model provides the following technical solutions: including a main frame, a reducer, a granulating tube, a spiral extrusion shaft and a drying bin;

[0007] A main driving motor is fixedly installed on the rear side of the lower end of the main frame, a first pulley is fixedly installed on the transmission shaft part at the rear end of the main driving motor, the first pulley is connected to the second pulley through a transmission belt, an extrusion hole disk is fixedly installed on the inner wall of the front end of the granulating tube, a granulating disk is fixedly installed in the middle of the front end of the granulating tube, a granulating hole is opened in the middle of the granulating disk, an extrusion cone is fixedly installed in the middle of the rear end of the granulating disk, and a feed trough is fixedly installed on the upper side of the rear end of the granulating tube;

[0008] A heater is fixedly installed on the outer wall of the drying bin, a heating copper tube is fixedly installed on the inner side of the heater, and a drying fan is fixedly installed on the top of the front end of the main frame;

[0009] The front end of the main frame is fixedly provided with an auxiliary supporting frame, the rear side of the upper end of the auxiliary supporting frame is fixedly provided with a limiting sliding bar, the outer curved surface of the limiting sliding bar is movably connected with a triangular mounting platform, the front side of the upper end of the triangular mounting platform is fixedly provided with an auxiliary driving motor, the front end transmission shaft part of the auxiliary driving motor passes through the triangular mounting platform, and the upper end of the triangular mounting platform is fixedly provided with a cutting tool holder, the front end support of the cutting tool holder is fixedly provided with a cutting blade, the upper end of the auxiliary supporting frame is threadedly connected with an adjusting screw, the front side of the main frame is fixedly provided with a discharge fan, the side end of the discharge fan is fixedly provided with a discharge pipe, and the upper end of the discharge pipe passes through and is fixedly provided with a collecting bucket.

[0010] Preferably, the middle part of the second pulley is fixedly installed on the rear end transmission shaft of the reducer, the front end transmission shaft part of the reducer is fixedly connected to the rear end of the spiral extrusion shaft through a coupling, the granulation tube support is fixedly installed on the upper end of the main frame, and the spiral extrusion shaft is rotatably connected to the inner wall of the granulation tube through a rotating shaft.

[0011] Preferably, the front end of the spiral extrusion shaft is conical, and is rotatably connected to the middle of the rear end of the extrusion hole disk through a rotating shaft. There are several granulation holes, which are rotationally symmetrically distributed at the outer end of the middle part of the granulation disk.

[0012] Preferably, the drying bin is fixedly installed on the front side of the upper end of the main frame, the drying bin surrounds the front end of the granulation tube inside, the heating copper tube extends to the lower end of the drying bin, a circulation hole is opened at the upper end of the drying bin, and the air outlet at the upper end of the drying fan extends to the bottom of the drying bin.

[0013] Preferably, there are two limit sliding rods, which are symmetrically distributed on the rear side of the upper end of the auxiliary support frame, and the rear end of the limit sliding rod is fixedly installed on the front end of the main frame.

[0014] Preferably, a dust cover is fixedly installed on the rear side of the upper end of the triangular mounting platform, and there are three cutting blades, which are rotationally symmetrically distributed at the front end of the cutting blade holder, and the cutting blades are located directly in front of the granulation hole.

[0015] Preferably, the outer curved surface at the front end of the adjusting screw is threadedly connected with a fastening nut for locking and fastening the adjusting screw, and the rear end of the adjusting screw is rotatably connected to the lower side of the front end of the triangular mounting platform via a rotating shaft.

[0016] Preferably, the upper opening of the collecting hopper is located directly below the granulation hole.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] 1. When the drying fan of the utility model is turned on, the heat generated by the heating copper tube will be blown upward, so as to pre-dry the drug raw materials inside the granulation tube. When the drug raw materials inside the granulation tube move forward and are pre-dried, the drug raw materials will be preliminarily extruded through the extrusion hole disk. After the drug raw materials are preliminarily extruded through the extrusion hole disk, they will continue to enter the granulation hole along the outer end of the extrusion cone for secondary extrusion. After the drug raw materials are secondary extruded through the granulation hole, the auxiliary drive motor is turned on by control. When the auxiliary drive motor is turned on, it will drive the cutting knife holder to rotate. When the cutting knife holder rotates , it will drive the cutting blade to cut the drug raw material after the secondary extrusion through the granulation hole, so that the drug raw material is cut into granules at the front end outlet of the granulation hole, and the drug cut into granules will fall into the collecting bucket at the same time. When the drug cut into granules falls into the collecting bucket, the discharge fan is turned on by control. When the discharge fan is turned on, the granular drug falling to the bottom of the collecting bucket will be finally blown and dried, and the granular drug will be blown out along the discharge pipe, so as to realize the preparation of drug granules and pre-dry the drug raw material before the preparation of drug granules is completed;

[0019] 2. In the utility model, when the adjusting screw is rotated, the adjusting screw will move forward and backward due to the force generated by the threaded connection with the upper end of the auxiliary support frame. When the adjusting screw moves forward and backward, it will drive the triangular mounting platform to move forward and backward along the outer curved surface of the limiting slide bar. When the triangular mounting platform moves forward and backward in a straight line, it will synchronously drive the cutting blade to move forward and backward in a straight line. When the cutting blade moves forward and backward in a straight line, the distance between the cutting blade and the granulation hole will increase or decrease, thereby achieving the effect of facilitating the adjustment of the length of the medicine cut into granules. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the overall structure of a biopharmaceutical drying granulator in this utility model. Figure 1 ;

[0021] Figure 2 This is a schematic diagram of the overall structure of a biopharmaceutical drying granulator in this utility model. Figure 2 ;

[0022] Figure 3 This is a schematic cross-sectional view of the overall structure of a biopharmaceutical drying and granulating machine according to the utility model;

[0023] Figure 4 The utility model is a schematic cross-sectional view of the local structure of a biopharmaceutical drying and granulating machine.

[0024] In the figure: 1. main frame; 2. reducer; 3. granulation tube; 4. spiral extrusion shaft; 5. extrusion hole disk; 6. granulation disk; 7. granulation hole; 8. extrusion cone; 9. feed trough; 10. heater; 11. heating copper tube; 12. drying fan; 13. limit slide bar; 14. triangular mounting table; 15. auxiliary drive motor; 16. cutting knife holder; 17. cutting blade; 18. adjusting screw; 19. discharge fan; 20. discharge pipe; 21. collecting bucket; 22. main drive motor; 23. first pulley; 24. second pulley; 25. auxiliary support frame; 26. drying bin. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-4The utility model provides a technical solution for a biopharmaceutical drying and granulating machine: it includes a main frame 1, a reducer 2, a granulating tube 3, a spiral extrusion shaft 4 and a drying chamber 26. A main driving motor 22 is fixedly installed on the rear side of the lower end of the main frame 1. A first pulley 23 is fixedly installed on the rear end transmission shaft of the main driving motor 22. The first pulley 23 is connected to a second pulley 24 through a transmission belt, and the middle part of the second pulley 24 is fixedly installed on the rear end transmission shaft of the reducer 2. The front end transmission shaft of the reducer 2 is fixedly connected to the rear end of the spiral extrusion shaft 4 through a coupling. The granulating tube 3 is supported and fixedly installed on the upper end of the main frame 1. The spiral extrusion shaft 4 is fixedly connected to the rear end of the spiral extrusion shaft 4 through a coupling. The granulating tube 3 is supported and fixedly installed on the upper end of the main frame 1. The spiral extrusion shaft 4 is rotatably connected to the inner wall of the granulation tube 3 through a rotating shaft, an extrusion hole disk 5 is fixedly installed on the inner wall of the front end of the granulation tube 3, the front end of the spiral extrusion shaft 4 is cone-shaped, and the front end of the spiral extrusion shaft 4 is rotatably connected to the middle of the rear end of the extrusion hole disk 5 through a rotating shaft, a granulation disk 6 is fixedly installed in the middle of the front end of the granulation tube 3, and a granulation hole 7 is opened in the middle of the granulation disk 6, and the number of granulation holes 7 is several, which are respectively distributed rotationally symmetrically at the outer end of the middle part of the granulation disk 6, an extrusion cone 8 is fixedly installed in the middle of the rear end of the granulation disk 6, and a feed trough 9 is fixedly installed on the upper side of the rear end of the granulation tube 3, so that the drug raw materials are put into the granulation tube 3 through the feed trough 9;

[0027] The drying bin 26 is fixedly installed on the front side of the upper end of the main frame 1, and the drying bin 26 surrounds the front end of the granulating tube 3 inside. A heater 10 is fixedly installed on the outer wall of the drying bin 26, and a heating copper tube 11 is fixedly installed on the inner side of the heater 10, and the heating copper tube 11 extends to the lower end of the drying bin 26. A flow hole is opened at the upper end of the drying bin 26, and a drying fan 12 is fixedly installed on the top of the front end of the main frame 1, and the air outlet at the upper end of the drying fan 12 extends to the bottom of the drying bin 26.

[0028] A secondary support frame 25 is fixedly installed at the front end of the main frame 1, and a limited sliding rod 13 is fixedly installed on the rear side of the upper end of the secondary support frame 25, and there are two limited sliding rods 13, which are symmetrically distributed on the rear side of the upper end of the secondary support frame 25. The rear end of the limited sliding rod 13 is fixedly installed at the front end of the main frame 1, and the outer curved surface of the limited sliding rod 13 is movably connected with a triangular mounting platform 14, and a dust cover is fixedly installed on the rear side of the upper end of the triangular mounting platform 14, and a secondary driving motor 15 is fixedly installed on the front side of the upper end of the triangular mounting platform 14. The front end transmission shaft part of the secondary driving motor 15 passes through the upper end of the triangular mounting platform 14 and is fixedly installed with a cutting tool holder 16, and the front end support of the cutting tool holder 16 is fixedly installed with a cutting The blade 17, and there are three cutting blades 17, which are rotationally symmetrically distributed at the front end of the cutting tool holder 16, and the cutting blade 17 is located directly in front of the granulation hole 7. The upper end of the auxiliary support frame 25 is threadedly connected with an adjusting screw 18, and the outer curved surface of the front end of the adjusting screw 18 is threadedly connected with a fastening nut for locking and fastening the adjusting screw 18. The rear end of the adjusting screw 18 is rotatably connected to the lower side of the front end of the triangular mounting platform 14 through a rotating shaft. A discharge fan 19 is fixedly installed at the front side end of the main frame 1, and a discharge pipe 20 is fixedly installed at the air outlet of the side end of the discharge fan 19. A collecting bucket 21 is fixedly installed at the upper end of the discharge pipe 20, and the upper end opening of the collecting bucket 21 is located directly below the granulation hole 7.

[0029] Working principle: When in use, the utility model puts the drug raw materials to be prepared into the granulation tube 3 through the feed trough 9. When the drug raw materials are put into the granulation tube 3, the main drive motor 22 is turned on by control. When the main drive motor 22 is turned on, it will drive the first pulley 23 to rotate. When the first pulley 23 rotates, it will drive the second pulley 24 to rotate through the transmission belt. When the second pulley 24 rotates, it will drive the reducer 2 to rotate. When the reducer 2 rotates, it will drive the spiral extrusion shaft 4 through the coupling. When the spiral extrusion shaft 4 rotates, the drug raw material inside the granulation tube 3 is pushed forward by the force generated by the rotation of the spiral blade on the outer curved surface of the spiral extrusion shaft 4. When the drug raw material inside the granulation tube 3 moves forward, the heater 10 is turned on by control. When the heater 10 is turned on, the heating copper tube 11 is heated. When the heating copper tube 11 is heated, the drying fan 12 is turned on by control. When the drying fan 12 is turned on, the heat generated by the heating copper tube 11 is blown upward, thereby pre-drying the drug raw material inside the granulation tube 3. After the drug raw materials inside the granulation hole 7 are pre-dried while moving forward, the drug raw materials will be preliminarily extruded through the extrusion hole plate 5. After the drug raw materials are preliminarily extruded through the extrusion hole plate 5, they will continue to enter the granulation hole 7 along the outer end of the extrusion cone 8 for secondary extrusion. After the drug raw materials are secondary extruded through the granulation hole 7, the auxiliary driving motor 15 is turned on by control. When the auxiliary driving motor 15 is turned on, it will drive the cutting knife frame 16 to rotate. When the cutting knife frame 16 rotates, it will drive the cutting blade 17 to cut the drug raw materials that have been secondary extruded through the granulation hole 7. The drug raw material is cut into granules at the front end outlet of the granulation hole 7, and the granules fall into the collecting bucket 21. When the granules fall into the collecting bucket 21, the discharge fan 19 is turned on by controlling. When the discharge fan 19 is turned on, the granules falling to the bottom of the collecting bucket 21 are finally blown and dried, and the granules are blown out along the discharge pipe 20, so that the drug granules are prepared and the drug raw material can be pre-dried before the preparation of the granules is completed.

[0030] At the same time, by rotating the loosening nut, when the fastening nut is loosened, by rotating the adjusting screw 18, when the adjusting screw 18 rotates, the adjusting screw 18 will move forward and backward due to the force generated by the threaded connection with the upper end of the auxiliary support frame 25. When the adjusting screw 18 moves forward and backward, it will drive the triangular mounting platform 14 to move forward and backward along the outer curved surface of the limiting slide bar 13. When the triangular mounting platform 14 moves forward and backward in a straight line, it will synchronously drive the cutting blade 17 to move forward and backward in a straight line. When the cutting blade 17 moves forward and backward in a straight line, the distance between the cutting blade 17 and the granulation hole 7 will become larger or smaller, thereby achieving the effect of facilitating the adjustment of the length of the medicine cut into granules.

[0031] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0032] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biopharmaceutical drying granulator, characterized in that: It comprises a main frame (1), a reducer (2), a granulation tube (3), a spiral extrusion shaft (4) and a drying chamber (26); A main driving motor (22) is fixedly installed on the rear side of the lower end of the main frame (1); a first pulley (23) is fixedly installed on the rear end transmission shaft of the main driving motor (22); the first pulley (23) is connected to a second pulley (24) through a transmission belt; an extrusion hole disk (5) is fixedly installed on the inner wall of the front end of the granulating tube (3); a granulating disk (6) is fixedly installed in the middle of the front end of the granulating tube (3); a granulating hole (7) is opened in the middle of the granulating disk (6); an extrusion cone (8) is fixedly installed in the middle of the rear end of the granulating disk (6); and a feed trough (9) is fixedly installed through the upper side of the rear end of the granulating tube (3); A heater (10) is fixedly installed on the outer wall of the drying chamber (26), a heating copper tube (11) is fixedly installed on the inner side of the heater (10), and a drying fan (12) is fixedly installed on the top of the front end of the main frame (1); The front end of the main frame (1) is fixedly provided with an auxiliary support frame (25), the rear side of the upper end of the auxiliary support frame (25) is fixedly provided with a limit slide bar (13), the outer curved surface of the limit slide bar (13) is movably connected with a triangular mounting platform (14), the front end of the triangular mounting platform (14) is fixedly provided with an auxiliary drive motor (15), the front end transmission shaft portion of the auxiliary drive motor (15) passes through the upper end of the triangular mounting platform (14) and is fixedly provided with a cutting tool holder (16), the front end support of the cutting tool holder (16) is fixedly provided with a cutting blade (17), the upper end of the auxiliary support frame (25) is threadedly connected with an adjusting screw (18), the front side of the main frame (1) is fixedly provided with a discharge fan (19), the side end of the discharge fan (19) is fixedly provided with a discharge pipe (20), and the upper end of the discharge pipe (20) is fixedly provided with a collecting bucket (21).

2. A biopharmaceutical drying granulator according to claim 1, characterized in that: The middle part of the second pulley (24) is fixedly installed on the rear end transmission shaft of the reducer (2); the front end transmission shaft of the reducer (2) is fixedly connected to the rear end of the spiral extrusion shaft (4) via a coupling; the granulation tube (3) support is fixedly installed on the upper end of the main frame (1); and the spiral extrusion shaft (4) is rotatably connected to the inner wall of the granulation tube (3) via a rotating shaft.

3. A biopharmaceutical drying granulator according to claim 2, characterized in that: The front end of the spiral extrusion shaft (4) is in a cone shape, and the front end of the spiral extrusion shaft (4) is rotatably connected to the middle of the rear end of the extrusion hole disk (5) via a rotating shaft. There are a plurality of granulation holes (7), which are rotationally symmetrically distributed at the outer end of the middle of the granulation disk (6).

4. A biopharmaceutical drying granulator according to claim 3, characterized in that: The drying bin (26) is fixedly installed on the front side of the upper end of the main frame (1), and the drying bin (26) surrounds the front end of the granulation tube (3) inside. The heating copper tube (11) extends to the inside of the lower end of the drying bin (26). A circulation hole is opened at the upper end of the drying bin (26), and the air outlet at the upper end of the drying fan (12) extends to the bottom of the drying bin (26).

5. A biopharmaceutical drying granulator according to claim 4, characterized in that: There are two limit slide bars (13), which are symmetrically distributed on the rear side of the upper end of the auxiliary support frame (25), and the rear end of the limit slide bar (13) is fixedly installed on the front end of the main frame (1).

6. A biopharmaceutical drying granulator according to claim 5, characterized in that: A dust cover is fixedly installed on the rear side of the upper end of the triangular mounting platform (14). There are three cutting blades (17) which are rotationally symmetrically distributed at the front end of the cutting blade holder (16). The cutting blades (17) are located directly in front of the granulation hole (7).

7. A biopharmaceutical drying granulator according to claim 6, characterized in that: The outer curved surface at the front end of the adjusting screw (18) is threadedly connected with a fastening nut for locking and fastening the adjusting screw (18), and the rear end of the adjusting screw (18) is rotatably connected to the lower side of the front end of the triangular mounting platform (14) via a rotating shaft.

8. A biopharmaceutical drying granulator according to claim 7, characterized in that: The upper opening of the collecting hopper (21) is located directly below the granulation hole (7).

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