Universal plate-type coil pipe structure for mixed solution in mRNA (messenger ribonucleic acid) preparation

Abstract

The utility model belongs to the technical field of coil pipe structures, in particular to a universal plate type coil pipe structure for mixed solution in mRNA (messenger Ribonucleic Acid) preparation, which comprises a base plate, an overlapping plate and a base plate, the base plate is movably sleeved with the base plate, the overlapping plate is movably sleeved with the base plate, the overlapping plate continues to be movably sleeved with the base plate, the base plate is fixed on a bottom plate, and the base plate is fixed on the bottom plate. The base plate is fixedly connected with a precise threaded column, the precise threaded column penetrates through the base plate, the stacking plate and the base plate and extends to the outside, the precise threaded column is movably sleeved with an extrusion plate, and a bubble level is embedded in the extrusion plate. According to the utility model, a solution flowing space is provided through a multi-layer sleeving structure, the device can be flexibly assembled and disassembled and is convenient to adjust and maintain, the pressure between plates can be accurately controlled through the matching of the precise threaded column, the extrusion plate and the precise screw cap, and the solution flowing and mixing effect is influenced; the flow path is compact, the occupied space is smaller, the stacked design can be achieved, and the feeding consistency and stability are guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of coil structures, in particular to a plate-type coil structure commonly used for mixed solutions in mRNA preparation. Background Art

[0002] The plate-coil structure commonly used for mixing solutions in mRNA preparation usually consists of coils, connecting pipes, pumps, valves, etc. The specific structure and design may vary depending on the application scenario and requirements.

[0003] In the process of mRNA separation and purification, oligo (dT)-cellulose column chromatography is a commonly used method. This method takes advantage of the fact that the 3' end of mRNA contains a Poly (A) tail, and achieves the separation and purification of mRNA through affinity binding with oligo (dT) cellulose.

[0004] The key design point of the plate-coil structure commonly used for mixing solutions in mRNA preparation is the coil layout: the coil layout can be spiral, serpentine or other forms to increase the residence time of the solution in the coil and the mixing effect.

[0005] Therefore, we proposed a universal plate-coil structure for mixing solutions in mRNA preparation to replace the traditional serpentine coil. Utility Model Content

[0006] 1. Technical issues to be resolved

[0007] In view of the deficiencies in the prior art, the utility model provides a universal plate-type coil structure for mixed solutions in mRNA preparation, which solves the problems raised in the above-mentioned background technology.

[0008] (II) Technical solution

[0009] In order to achieve the above-mentioned purpose, the utility model specifically adopts the following technical solutions:

[0010] A plate-type coil structure commonly used for mixed solutions in mRNA preparation comprises a pad, a stacking plate and a base plate, wherein the base plate is movably sleeved with the pad, the pad is movably sleeved with the stacking plate, the stacking plate is further movably sleeved with the pad, the base plate is fixed to a bottom plate, a precision threaded column is fixedly connected to the bottom plate, the precision threaded column penetrates the pad, the stacking plate and the base plate and extends to the outside, an extrusion plate is movably sleeved on the precision threaded column, a bubble level is inlaid and installed on the extrusion plate, a precision nut is threadedly connected to the precision threaded column, a feed port is provided on the pad, a discharge port is provided on the side of the base plate, a double-sided guide groove is provided on the stacking plate, and a single-sided guide groove is provided on the base plate.

[0011] Furthermore, the bubble level is circular in shape.

[0012] Furthermore, a guide hole is provided between the guide grooves on both sides parallel to the feed port.

[0013] Furthermore, the feed openings of the plurality of pads are designed to have the same position.

[0014] (III) Beneficial effects

[0015] Compared with the prior art, the utility model provides a universal plate-type coil structure for mixed solutions in mRNA preparation, which has the following beneficial effects:

[0016] The utility model provides solution flow space through its multi-layer socket structure and can be flexibly assembled and disassembled, which is convenient for adjustment and maintenance. The precision threaded column, the extrusion plate and the precision nut can cooperate to accurately control the pressure between the plates, affecting the solution flow and mixing effect; the flow path is compact, the space occupied is smaller, and the stackable design ensures the consistency and stability of the feed. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the structure of the utility model;

[0018] Figure 2 This is a schematic diagram of an explosion top view of the utility model;

[0019] Figure 3 It is a schematic diagram of an explosion viewed from above of the utility model.

[0020] In the figure: 1. pad; 2. stacking plate; 3. base plate; 4. bottom plate; 5. precision threaded column; 6. extrusion plate; 7. bubble level; 8. precision nut; 9. feed port; 10. discharge port; 11. guide groove. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example

[0023] like Figure 1-3As shown, a plate-type coil structure universal for mixed solutions in mRNA preparation proposed in one embodiment of the utility model comprises a pad 1, a stacking plate 2 and a base plate 3, the base plate 3 is movably sleeved with the pad 1, the pad 1 is movably sleeved with the stacking plate 2, the stacking plate 2 continues to movably sleeve the pad 1, the base plate 3 is fixed on the bottom plate 4, the bottom plate 4 is fixedly connected with a precision threaded column 5, the precision threaded column 5 penetrates the pad 1, the stacking plate 2 and the base plate 3 and extends to the outside, the precision threaded column 5 is movably sleeved with an extrusion plate 6, the extrusion plate 6 is inlaid with a bubble level 7, the precision threaded column 5 is threadedly connected with a precision nut 8, the pad 1 is provided with a feed port 9, the side of the base plate 3 is provided with a discharge port 10, the stacking plate 2 is provided with a double-sided guide groove 11, and the base plate 3 is provided with a single-sided guide groove 11;

[0024] The backing plate 1, the stacking plate 2 and the base plate 3 form a multi-layer structure by being connected to each other, providing a channel and space for the flow of the mixed solution. The movable connection method allows the entire structure to be assembled and disassembled flexibly, which is convenient for adjustment and maintenance according to actual needs. The base plate 3 is fixed on the bottom plate 4, providing a stable foundation to ensure that the entire device remains stable during operation. The precision threaded column 5 plays a role in fixing and adjusting the tightness between the layers of the plates. Through the cooperation of the extrusion plate 6 and the precision nut 8, the pressure between the plates can be accurately controlled, thereby affecting the flow and mixing effect of the solution.

[0025] Bubble level 7: helps to ensure that the entire device is level, ensuring uniformity and accuracy of mixing;

[0026] Feed inlet 9 and discharge port 10: define the inlet and outlet positions of the solution, guide grooves 11 on the stacking plate 2 and the base plate 3: these guide grooves 11 form the path for the solution to flow, and the double-sided and single-sided designs can achieve different circulation and mixing effects;

[0027] The guide hole can further guide the flow of the solution. The feed ports 9 of multiple pads 1 are in the same position, which ensures the consistency and repeatability of the feed.

[0028] In general, this plate-coil structure is relatively sophisticated in design. Through the synergistic effect of various components, it provides an effective solution for the processing of mixed solutions in mRNA preparation, which can achieve better mixing effect and precise control.

[0029] like Figure 1As shown, in some embodiments, the bubble level 7 is circular in shape. The circular bubble level 7 has some advantages, such as being easier to visually observe and judge the horizontal state, and its rounded shape may also be easier to install and embed on the extrusion plate 6, helping to ensure that the entire coil structure remains level during installation and use, which is very important for the uniform flow and precise reaction of the mixed solution.

[0030] like Figure 2 As shown, in some embodiments, a guide hole is provided between the double-sided guide grooves 11 on the parallel sides of the feed port 9, which serves to further guide the flow direction of the solution, so that the mixed solution can flow in the guide groove 11 more accurately according to the designed path, avoiding disordered flow or local accumulation.

[0031] like Figure 3 As shown, in some embodiments, the feed ports 9 of the multiple pads 1 are designed to have the same position, which ensures the consistency and stability of the feed. No matter which pad 1 is used, the feed position is fixed and clear, which helps to accurately control the time and amount of the feed, ensure the consistency of the feed conditions in each experiment or production process, and thus reduce the result deviation caused by feed differences.

[0032] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A plate-type coil structure for mixing solutions in mRNA preparation, comprising a pad (1), a stacking plate (2) and a base plate (3), characterized in that: A pad (1) is movably sleeved on the base plate (3), a stacking plate (2) is movably sleeved on the pad plate (1), the stacking plate (2) is further movably sleeved on the pad plate (1), the base plate (3) is fixed on the bottom plate (4), a precision threaded column (5) is fixedly connected to the bottom plate (4), the precision threaded column (5) penetrates the pad plate (1), the stacking plate (2) and the base plate (3) and extends to the outside, an extrusion plate (6) is movably sleeved on the precision threaded column (5), a bubble level (7) is embedded and installed on the extrusion plate (6), a precision nut (8) is threadedly connected to the precision threaded column (5), a feed port (9) is provided on the pad plate (1), a discharge port (10) is provided on the side of the base plate (3), a double-sided guide groove (11) is provided on the stacking plate (2), and a single-sided guide groove (11) is provided on the base plate (3).

2. The plate-coil structure for mixing solutions in mRNA preparation according to claim 1, characterized in that: The bubble level (7) is circular in shape.

3. The plate-coil structure for mixing solutions in mRNA preparation according to claim 1, characterized in that: A guide hole is provided between the double-sided guide grooves (11) on the parallel side surfaces of the feed port (9).

4. The plate-coil structure for mixing solutions in mRNA preparation according to claim 1, characterized in that: The feed openings (9) of the plurality of pads (1) are designed to have the same position.

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