Laboratory mouse skull plane adjusting and auxiliary positioning device

Abstract

The utility model discloses a laboratory mouse skull plane adjusting and auxiliary positioning device which comprises a pedestal, a U-shaped ear rod adapter is arranged in the middle of the pedestal, ear rods which are used for stretching into ears of a laboratory mouse and are adjustable in height are detachably installed at the two ends of an opening of the ear rod adapter, and a tooth fixing mechanism is arranged in the arc-shaped middle of the ear rod adapter. A sliding table and a sliding rail moving relative to the sliding table are arranged on the side, located on the arc-shaped side of the lug rod adapter, of the pedestal, a transverse and vertical translation mechanism is installed on the sliding rail and comprises a vertical translation assembly and a transverse translation assembly, and a positioning needle and an injection needle which are opposite to the lug rod adapter are installed at the front end of the transverse translation assembly. An X-axis laser transmitter capable of moving in the transverse direction is arranged on the side, opposite to the opening of the lug rod adapter, of the pedestal, and a Y-axis laser transmitter capable of moving in the longitudinal direction is arranged on the side adjacent to the X-axis laser transmitter. According to the utility model, the X-axis laser transmitter and the Y-axis laser transmitter are adopted, so that the skull plane of the head of the laboratory mouse can be conveniently adjusted, the skull plane reaches horizontal balance, and the positioning needle is adopted to accurately mark the required position without manual marking.

Description

Technical Field

[0001] The utility model relates to the technical field of brain stereo positioning devices, in particular to a device for adjusting and assisting the positioning of the skull plane of experimental mice. Background Art

[0002] Rats and mice are the most commonly used experimental animals, especially in research involving the nervous system. Almost all natural science knowledge of nerves comes from experimental animals such as rats and mice. Since the surface of the skull of experimental mice is uneven, the animal's head needs to be fixed on a stereotaxic instrument and directly inserted into the ventricle to inject drugs. The stereotaxic instrument is a high-precision device commonly used in neuroscience research and clinical surgery. At present, scientific research laboratories in various universities often purchase and use rotating stereotaxic instruments. This instrument is widely used, but when conducting stereotaxic experiments, it is necessary to repeatedly adjust the skull of the rat to control stability and balance, and use sensory memory or marker pen marking to locate and drill the target brain area of ​​the rat. This operation method will cause the rat's skull to be unstable and unbalanced, and inaccurate positioning will cause subsequent experiments to deviate from the target brain area, which is time-consuming and labor-intensive, and the accuracy of the experiment cannot be guaranteed due to individual differences. Utility Model Content

[0003] The utility model provides an experimental mouse skull plane adjustment and auxiliary positioning device with simple structure, high experimental efficiency and time saving and high accuracy.

[0004] The experimental mouse skull plane adjustment and auxiliary positioning device described in the utility model comprises a pedestal, a U-shaped ear rod adapter is arranged in the middle of the pedestal, ear rods for inserting into the ears of the experimental mouse and having adjustable height are detachably installed at both ends of the opening of the ear rod adapter, a tooth fixing mechanism is arranged in the arc-shaped middle part of the ear rod adapter, a sliding table and a slide rail moving relative to the sliding table are arranged on one side of the pedestal located at the arc-shaped ear rod adapter, a horizontal and vertical translation mechanism is arranged on the slide rail, the horizontal and vertical translation mechanism comprises a vertical translation component and a horizontal translation component, a positioning needle and an injection needle opposite to the ear rod adapter are arranged at the front end of the horizontal translation component, an X-axis laser emitter displaceable in the horizontal direction is arranged on the side of the pedestal opposite to the opening of the ear rod adapter, and a Y-axis laser emitter displaceable in the longitudinal direction is arranged on the side adjacent to the X-axis laser emitter.

[0005] Preferably, two adjacent sides of the base are respectively provided with slide grooves for installing the X-axis laser emitter and the Y-axis laser emitter.

[0006] Preferably, fixing seats are provided at both ends of the ear rod adapter opening, a groove for placing the ear rod is provided in the middle of the fixing seat, and a fixing screw is provided on one side of the groove for screwing in to abut against the ear rod and screwing out to loosen the ear rod.

[0007] Preferably, an elongated cavity is provided in the arc-shaped middle portion of the ear rod adapter, and an elongated window is provided above the cavity. The tooth fixing mechanism is a perforated plate installed in the cavity and movable in the cavity, and one end of the perforated plate is provided with a toggle rod passing through the window for moving the perforated plate.

[0008] Preferably, vertically shaped knobs for adjusting the height of the laser emission source up and down are provided on the top of the X-axis laser emitter and the Y-axis laser emitter.

[0009] Preferably, a fixing block is provided at the front end of the lateral translation assembly, and fixing holes for fixing the positioning needle and the injection needle are respectively provided on the fixing block.

[0010] Preferably, the vertical translation assembly includes two vertical sliding columns fixed on the slide rails, a base plate connected to the two vertical sliding columns, a vertical sliding block mounted on the vertical sliding column and capable of moving up and down relative to the vertical sliding column, and a vertical threaded rod passing through the base plate and the vertical sliding block; the lateral translation assembly includes a lateral sliding column passing through the vertical sliding block and capable of horizontal displacement relative to the vertical sliding block, a fixed plate provided at one end of the lateral sliding column, and a lateral threaded rod passing through the fixed plate and the vertical sliding block; a positioning pin and an injection needle are installed at the other end of the lateral sliding column opposite to the ear rod adapter.

[0011] The experimental mouse skull plane adjustment and auxiliary positioning device is configured to fix the experimental mouse on the ear rod adapter, with the head facing the tooth fixing mechanism, the upper teeth hanging into the tooth fixing mechanism, and the ear rods on both sides extending into the external auditory canal for preliminary fixation; then, a horizontal plane is formed for reference through an X-axis laser emitter and a Y-axis laser emitter with adjustable displacement in the horizontal and vertical directions, and the experimental mouse is adjusted through the height-adjustable ear rod so that the skull plane of the experimental mouse is aligned with the horizontal plane formed by the X-axis laser emitter and the Y-axis laser emitter, and then the injection position is cut horizontally and the point marking and drilling are performed through the positioning target, so that the syringe at the front end of the horizontal translation mechanism can be conveniently injected with drugs. The utility model has a simple structure, and the X-axis laser emitter and the Y-axis laser emitter can be used to adjust the skull plane of the experimental mouse head so that the skull plane reaches horizontal balance, and the positioning needle can be used to accurately mark the required position without manual marking, so that the experiment is efficient and time-saving, with high accuracy, and the experimental efficiency is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 The figure is a schematic diagram of the structure of a device for adjusting the plane of the skull of experimental mice and assisting in positioning.

[0013] Figure 2 A side view of a device for adjusting the plane of the skull of experimental mice and assisting in positioning the skull.

[0014] Figure 3 The figure is a schematic diagram of the use of a device for adjusting the plane of the skull of an experimental mouse and for assisting in positioning the skull. DETAILED DESCRIPTION

[0015] like Figure 1-3 As shown, a device for adjusting the plane of skull of an experimental mouse and assisting in positioning is provided, comprising a pedestal 1, a U-shaped ear rod adapter 2 is provided in the middle of the pedestal 1, ear rods 3 for inserting into the ears of the experimental mouse and having adjustable height are detachably installed at both ends of the opening of the ear rod adapter, a tooth fixing mechanism 4 is provided in the arc-shaped middle of the ear rod adapter, a slide 5 and a slide rail 6 moving relative to the slide are provided on one side of the pedestal located at the arc-shaped ear rod adapter, a horizontal and vertical translation mechanism 7 is installed on the slide rail, the horizontal and vertical translation mechanism comprises a vertical translation component 8 and a horizontal translation component 9, a positioning pin 10 and an injection needle 11 opposite to the ear rod adapter are installed at the front end of the horizontal translation component, an X-axis laser emitter 12 displaceable in the horizontal direction is provided on the side of the pedestal opposite to the opening of the ear rod adapter, and a Y-axis laser emitter 13 displaceable in the longitudinal direction is provided on the side adjacent to the X-axis laser emitter. The experimental mouse is fixed on the ear rod adapter, with the head facing the tooth fixing mechanism, the upper teeth are hung in the tooth fixing mechanism, and the ear rods on both sides are extended into the external auditory canal for preliminary fixation; then, a horizontal plane is formed for reference through an X-axis laser transmitter and a Y-axis laser transmitter with adjustable displacement in the horizontal and vertical directions, and the experimental mouse is adjusted through the ear rod with adjustable height so that the skull plane of the experimental mouse is aligned with the horizontal plane formed by the X-axis laser transmitter and the Y-axis laser transmitter, and then the required injection position is cut and the point marking drilling is performed through the positioning needle, so that the syringe at the front end of the horizontal translation mechanism is convenient for injecting drugs. The utility model has a simple structure, and the X-axis laser transmitter and the Y-axis laser transmitter can be used to adjust the skull plane of the experimental mouse head so that the skull plane reaches horizontal balance, and the positioning needle can be used to accurately mark the required position without manual marking. The experiment is efficient and time-saving, with high accuracy, and the experimental efficiency is improved.

[0016] The size of the experimental mice varies, so after the experimental mice are placed on the pedestal, the position of the skull is not uniquely fixed. Therefore, the adjacent two sides of the pedestal are respectively provided with slide grooves 14 for installing the X-axis laser emitter and the Y-axis laser emitter, so as to facilitate the movement of the X-axis laser emitter and the Y-axis laser emitter.

[0017] Fixed seats 15 are provided at both ends of the opening of the ear rod adapter. A groove for placing the ear rod is provided in the middle of the fixed seat. A fixing screw is provided on one side of the groove, which is screwed in to abut against the ear rod for fixing and screwed out to loosen the ear rod. The ear rod is fixed or loosened by the fixing screw. After adjusting the height and tilt angle of the ear rod, the ear rod is fixed by the fixing screw, which is conducive to adjusting the skull surface of the experimental mouse to be aligned with the horizontal plane.

[0018] The arc-shaped middle part of the ear bar adapter is provided with a long strip of cavity, and a long strip of window is provided above the cavity. The tooth fixing mechanism 4 is a perforated sheet installed in the cavity and movable in the cavity, and a toggle rod passing through the window and used to move the perforated sheet is provided at one end of the perforated sheet. By moving the toggle rod, the perforated sheet can be quickly aligned with the incisors of the experimental mouse, so as to achieve the effect of fixing the head of the experimental mouse.

[0019] The top of the X-axis laser emitter and the Y-axis laser emitter is provided with a vertical knob 16 for adjusting the height of the laser emission source up and down. The height of the horizontal plane formed by the X-axis laser emitter and the Y-axis laser emitter can be adjusted to adapt to the size of various types of experimental mice.

[0020] A fixing block 17 is provided at the front end of the lateral translation assembly, and fixing holes 18 for fixing the positioning needle and the injection needle are respectively provided on the fixing block.

[0021] The vertical translation assembly 8 includes two vertical sliding columns 801 fixed on the sliding rail, a base plate 802 connected to the two vertical sliding columns, a vertical slider 803 mounted on the vertical sliding column and capable of moving up and down relative to the vertical sliding column, and a vertical threaded rod 804 passing through the base plate and the vertical slider. The horizontal translation assembly 9 includes a horizontal sliding column 901 passing through the vertical slider and capable of horizontal displacement relative to the vertical slider, a fixed plate 902 is arranged at one end of the horizontal sliding column, and a horizontal threaded rod 903 passing through the fixed plate and the vertical slider; a positioning needle and an injection needle are installed at the other end of the horizontal sliding column opposite to the ear rod adapter.

Claims

1. A device for adjusting the plane of the skull of an experimental mouse and for assisting its positioning, comprising a stand (1), characterized in that: A U-shaped ear rod adapter (2) is provided in the middle of the pedestal (1), and ear rods (3) for inserting into the ears of experimental mice and having adjustable height are detachably installed at both ends of the opening of the ear rod adapter. A tooth fixing mechanism (4) is provided in the arc-shaped middle of the ear rod adapter. A slide table (5) and a slide rail (6) movable relative to the slide table are provided on one side of the pedestal located at the arc-shaped ear rod adapter, and a horizontal and vertical translation mechanism (7) is installed on the slide rail. The horizontal and vertical translation mechanism includes a vertical translation component (8) and a horizontal translation component (9), and a positioning pin (10) and an injection needle (11) opposite to the ear rod adapter are installed at the front end of the horizontal translation component. An X-axis laser emitter (12) capable of being displaced in the horizontal direction is provided on the side of the pedestal opposite to the opening of the ear rod adapter, and a Y-axis laser emitter (13) capable of being displaced in the longitudinal direction is provided on the side adjacent to the X-axis laser emitter.

2. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: Two adjacent sides of the pedestal are respectively provided with slide grooves (14) for installing an X-axis laser transmitter and a Y-axis laser transmitter.

3. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: Both ends of the ear rod adapter opening are provided with fixing seats (15), the middle of the fixing seat is provided with a groove for placing the ear rod, and one side of the groove is provided with a fixing screw that is screwed in to abut against the ear rod for fixing and screwed out to loosen the ear rod.

4. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: The arc-shaped middle part of the ear rod adapter is provided with a long strip-shaped cavity, and a long strip-shaped window is provided above the cavity. The tooth fixing mechanism (4) is a perforated plate installed in the cavity and movable in the cavity, and one end of the perforated plate is provided with a toggle rod passing through the window and used to move the perforated plate.

5. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: A vertically shaped knob (16) for adjusting the height of the laser emission source upward and downward is arranged on the top of the X-axis laser emitter and the Y-axis laser emitter.

6. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: A fixing block (17) is provided at the front end of the transverse translation assembly, and fixing holes (18) for fixing the positioning needle and the injection needle are respectively provided on the fixing block.

7. The experimental mouse skull plane adjustment and auxiliary positioning device according to claim 1, characterized in that: The vertical translation assembly (8) comprises two vertical sliding columns (801) fixed on the slide rail, a base plate (802) connected to the two vertical sliding columns, a vertical sliding block (803) sleeved on the vertical sliding column and capable of moving up and down relative to the vertical sliding column, and a vertical threaded rod (804) passing through the base plate and the vertical sliding block; the horizontal translation assembly (9) comprises a horizontal sliding column (901) passing through the vertical sliding block and capable of horizontal displacement relative to the vertical sliding block, a fixing plate (902) provided at one end of the horizontal sliding column, and a horizontal threaded rod (903) passing through the fixing plate and the vertical sliding block; and a positioning needle and an injection needle opposite to the ear rod adapter are installed at the other end of the horizontal sliding column.

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