A capping device

Abstract

The present application provides a capping device, which belongs to the technical field of medical experimental equipment. The capping device provided in the present application includes a capping platform, a consumable component, a top cover component, a transfer component and a capping component. The capping platform is provided with a groove, in which a microplate is placed; the consumable component is provided beside the capping platform, for placing a consumable box, in which a lid is placed; the top cover component is provided below the consumable component, for lifting up the lid on the consumable component, the capping component is installed on the transfer component, the capping component grabs the lifted lid, the transfer component drives the capping component to transfer horizontally to the top of the capping platform, and the capping component moves downward to press the grabbed lid onto the reaction hole of the microplate to seal the microplate. The present application adopts a capping method to seal the multi-well plate, which can ensure the consistency of the seal.

Description

Technical Field

[0001] The present application belongs to the technical field of medical experimental equipment, and specifically relates to a capping device. Background Art

[0002] Medical experiments often require sealing of 48-well, 96-well and other multi-well plates or eight-well tubes. In the prior art, hot pressing devices are generally used for sealing. However, it is often difficult to replace consumables in hot pressing devices, and the sealing consistency is difficult to control. It is easy for some holes to be poorly sealed, resulting in mutual contamination or leakage.

[0003] Therefore, it is necessary to provide a capping device to solve the problems mentioned in the above background technology. Summary of the invention

[0004] The present application provides a capping device, which uses a capping method to seal a porous plate, which can effectively avoid the problem that the sealing consistency is difficult to control, and some holes are easily poorly sealed, resulting in mutual contamination or leakage.

[0005] In order to solve the above technical problems, the technical solution of this application is:

[0006] A capping device comprises a capping platform, a consumable assembly, a top cover assembly, a transfer assembly and a capping assembly, wherein the capping platform is provided with a groove in which a microplate is placed; the consumable assembly is arranged beside the capping platform and is used to place a consumable box, in which a lid is placed; the top cover assembly is arranged below the consumable assembly and is used to lift up a lid on the consumable assembly, the capping assembly is mounted on the transfer assembly, the capping assembly grabs the lifted lid, the capping assembly moves upward to grab the lid, the transfer assembly drives the capping assembly to be transferred horizontally to above the capping platform, the capping assembly moves downward to place and press the grabbed lid onto a reaction hole of the microplate to seal the microplate.

[0007] Preferably, it also includes a base, which includes a bottom plate, on which a first support plate, a second support plate and a third support plate for support are installed, the first support plate, the second support plate and the third support plate are arranged in parallel and spaced apart in sequence, the two ends of the pressure cover platform are respectively supported on the first support plate and the second support plate, and the two ends of the consumable assembly are respectively supported on the second support plate and the third support plate.

[0008] Preferably, a pressure pad is laid on the microwell plate, a plurality of reaction holes are opened on the microwell plate, a plurality of through holes are opened on the pressure pad, the through holes are arranged in one-to-one correspondence with the reaction holes, and the aperture of the reaction holes is smaller than the aperture of the through holes.

[0009] Preferably, two cover plates are installed on the capping platform, the two cover plates are located on opposite sides of the groove, and the inner edges of the cover plates are aligned with the edges of the groove. The edges of the cover plates are processed with bevels, which serve as guides when placing the microporous plate.

[0010] Preferably, a positioning structure is also provided on the cover pressing platform, and the positioning structure includes two pairs of slide rails symmetrically installed under the cover pressing platform, a slide rail connector installed on the slide rail, a limit connector symmetrically installed on the slide rail connector, a limit plate installed on the limit connector, a limit rotating part installed in the middle of the bottom surface of the cover pressing platform and a limit connecting rod installed on the slide rail connector, wherein the limit rotating part is provided with a first bearing, the rotating shaft passes through the first bearing and is fixed on the cover pressing platform, the limit rotating part rotates around the rotating shaft, and a roller is also installed on the limit connecting rod, and the roller is simultaneously located in a U-shaped groove on the limit rotating part, and when the limit rotating part rotates, the roller also follows the movement, so that the two limit plates located on both sides of the groove on the cover pressing platform move toward the middle at the same time, so as to assist in positioning the cover.

[0011] Preferably, the consumable assembly includes a consumable fixing base plate, the two edges of the consumable fixing base plate are respectively fixed on the second support plate and the third support plate, the left and right sides and the back of the consumable fixing base plate are respectively installed with a first baffle, a second baffle and a third baffle, the first baffle and the second baffle are both provided with grooves and ball-shaped holes, ball-shaped screws are installed in the ball-shaped holes, the consumable box is provided with a convex edge and a second positioning hole, when the consumable box is pushed in from the front, the convex edge on the consumable box is just located in the groove, after the consumable box is pushed into place, the head of the ball-shaped screw is just located at the second positioning hole of the consumable box, the consumable box is also designed with two first square holes, and the consumable fixing base plate is also designed with two second square holes, when the consumable box is placed in place, the first square hole is just aligned with the second square hole.

[0012] Preferably, the top cover assembly includes a lifting member, which is located below the second square hole. The lifting member is installed on a fifth slide rail and can move up and down along the fifth slide rail. The fifth slide rail is installed on a lifting fixing plate, and the lifting fixing plate is vertically installed below the consumable fixing bottom plate. When the lifting member rises, the lifting member passes through the second square hole and the first square hole to lift up the cover in the consumable box.

[0013] Preferably, the transfer assembly includes a second slide rail and a first motor, a connecting plate is installed on the second slide rail, a pressure cover support plate is installed on both sides of the connecting plate, and the connecting plate and the pressure cover support plate can move along the second slide rail; the first motor is installed on the base plate, and the first synchronous pulley and the first tensioning pulley on the first motor are connected by a synchronous belt to form a synchronous belt transmission structure, the connecting plate is connected to the synchronous belt, and the connecting plate can be moved along the second slide rail by controlling the forward and reverse rotation of the first motor, and the pressure cover assembly is installed on the pressure cover support plate.

[0014] Preferably, the capping assembly includes a capping head fixing plate, a second motor is installed on one side of the capping head fixing plate, and two pairs of third slide rails parallel to each other are installed on the other side. The capping pressure plate is installed on the third slide rail and connected to the sliders of the two pairs of third slide rails at the same time. The capping pressure plate can perform vertical lifting movement along the third slide rail, and the capping pressure plate is used to press the cover into the reaction hole on the microwell plate; a cap grabbing base plate is also installed under the capping head fixing plate, and the two sides of the cap grabbing reinforcement plate are respectively connected to the capping head fixing plate and the cap grabbing base plate, and the cap grabbing base plate is also installed with a fourth slide rail, and two cap grabbing claws are respectively connected to a slider on the fourth slide rail, and the two cap grabbing claws can move along the fourth slide rail to form a clamping mechanism, and the clamping mechanism is used to grab the cover.

[0015] Preferably, the cover grabbing claw piece is also equipped with a cover grabbing push plate and a cover grabbing spring pressure plate, and a spring is clamped between the cover grabbing spring pressure plate and the cover grabbing reinforcement plate, and the cover grabbing claw piece is pushed outward under the elastic force of the spring; two cover grabbing pillars are also installed on the cover pressing plate, and a second bearing is installed on the top of the cover grabbing pillar, and the second bearing is in contact with the cover grabbing push plate. When the second bearing moves up and down with the cover pressing plate, the second bearing also causes the cover grabbing claw piece to close inward to clamp the cover.

[0016] The beneficial effects of this application are:

[0017] (1) The present application adopts a pressure capping method to seal the porous plate, thereby ensuring sealing and having a small structure volume;

[0018] (2) The capping structure and the cap consumables are integrated into one set of equipment, so that a box of consumables can be put in at a time and automatically grabbed for use, which is convenient and fast;

[0019] (3) The plate does not need to be moved during the capping process, which can ensure the consistency of the seal and reduce the risk of contamination.

[0020] (4) During the capping process, the microplate can be capped in multiples of 8, and with a detachable lid, the number of caps can be flexible;

[0021] (5) The press cap can be used to press a single 8-well tube or a 96-well plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 A structural diagram showing a capping device provided by the present application;

[0023] Figure 2 A schematic diagram showing the installation of the gland platform on the base;

[0024] Figure 3 A schematic diagram showing the structure of the base;

[0025] Figure 4 A schematic diagram showing a portion of the structure of the capping platform;

[0026] Figure 5 A schematic diagram showing the structure of the capping platform;

[0027] Figure 6 A diagram showing the structure of the outer cover of the gland assembly;

[0028] Figure 7 A partial structural diagram showing the gland assembly;

[0029] Figure 8 A structural diagram showing another angle of the gland assembly;

[0030] Fig. 9 A structural diagram showing the consumable box;

[0031] Fig.10 A schematic diagram showing the structure of the consumable assembly;

[0032] Fig.11 A structural diagram showing another angle of the consumable assembly;

[0033] Fig.12 A partial structural diagram showing the capping platform;

[0034] Fig.13 A partial structural diagram showing the capping platform;

[0035] Fig.14 A partial structural diagram showing the transfer assembly;

[0036] Fig.15 A structural diagram showing another angle of the transfer assembly. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0038] Please refer to Figure 1-Figure 15 The present application provides a capping device, including a capping platform, a consumable assembly, a top cover assembly, a transfer assembly and a capping assembly, wherein a groove is provided on the capping platform, in which a microplate is placed; the consumable assembly is provided beside the capping platform for placing a consumable box, in which a lid is placed; the top cover assembly is provided below the consumable assembly for lifting up a lid on the consumable assembly, the capping assembly is installed on the transfer assembly, the capping assembly grabs the lifted lid, the transfer assembly drives the capping assembly to transfer horizontally to above the capping platform, the capping assembly moves downward to press the grabbed lid onto the reaction hole of the microplate to seal the microplate.

[0039] The base comprises a bottom plate 1, on which a first support plate 2, a second support plate 3 and a third support plate 4 for support are mounted, and the first support plate 2, the second support plate 3 and the third support plate 4 are sequentially arranged in parallel and spaced apart.

[0040] The two ends of the capping platform 5 are respectively supported on the first support plate 2 and the second support plate 3. The capping platform 5 has a groove 501, and the groove 501 is used to place the micro-well plate 6. The capping pad 7 is laid on the micro-well plate 6. The micro-well plate 6 is provided with a plurality of reaction holes 601. The capping pad 7 is provided with a plurality of through holes 701. The through holes 701 are arranged in a one-to-one correspondence with the reaction holes 601, and the aperture of the reaction hole 601 is smaller than the aperture of the through hole 701, that is, the reaction holes 601 are all within the range of the through hole 701.

[0041] Two cover plates 8 are also installed on the capping platform 5. The two cover plates 8 are located on opposite sides of the groove 501, and the inner edges of the cover plates 8 are aligned with the edges of the groove 501. The edges of the cover plates 8 are processed with bevels 801, and the bevels 801 serve as guides when placing the microporous plate 6.

[0042] The capping platform 5 is also provided with a positioning structure for assisting the positioning of the cover 9. The positioning structure includes two pairs of slide rails 10 symmetrically installed below the capping platform 5, a slide rail connector 11 installed on the slide rail 10, a limit connector 12 symmetrically installed on the slide rail connector 11, a limit plate 13 installed on the limit connector 12, a limit rotating member 14 installed in the middle of the bottom surface of the capping platform 5, and a limit connecting rod 15 installed on the slide rail connector 11, wherein the limit rotating member 14 is provided with a first bearing 16. The rotating shaft 17 passes through the first bearing 16 and is fixed on the capping platform 5. The limiting rotating member 14 rotates around the rotating shaft 17. A roller 18 is also installed on the limiting connecting rod 15. The roller 18 is also located in the U-shaped groove 1401 on the limiting rotating member 14. When the limiting rotating member 14 rotates, the roller 18 also follows the movement, so that the two limiting plates 13 located on both sides of the groove 501 on the capping platform 5 move toward the middle at the same time, so as to assist in positioning the cover 9 to be placed on the microplate 6.

[0043] The transfer assembly includes a second slide rail 19 and a first motor 22 . A connecting plate 20 is installed on the second slide rail 19 . A gland support plate 21 is installed on both sides of the connecting plate 20 . The connecting plate 20 and the gland support plate 21 can move along the second slide rail 19 .

[0044] The first synchronous pulley 23 and the first tensioner 24 on the first motor 22 are connected by a synchronous belt 25 to form a synchronous belt transmission structure. The connecting plate 20 is connected to the synchronous belt 25. By controlling the forward and reverse rotation of the first motor 22, the connecting plate 20 can be moved along the second slide rail 19. A baffle 54 is installed on the gland support plate 21 on one side, and a third sensor 55 is installed on the bottom plate 1. When the connecting plate 20 moves to the rightmost end, the baffle 54 is detected by the third sensor 55.

[0045] The slide rail connector 11 is also provided with a stopper 65. When the connecting plate 20 moves to the rightmost end, the push plate 201 on the connecting plate 20 pushes the stopper 65, so that the slide rail connector 11 also moves rightward, and the limit rotation member 14 rotates through the limit connecting rod 15 and the roller 18, so that the two limit plates 13 move away from each other, so that the microplate 6 can be placed or removed. When the connecting plate 20 moves to the left, the tension spring 66 connected to the two slide rail connectors 11 makes the two limit plates 13 move closer to each other.

[0046] The base is also provided with a front cover plate 67 and a rear cover plate 68, and both sides of the capping platform 5 are also provided with decorative cover plates 69 for protecting and decorating the internal structure.

[0047] The gland assembly is fixed on the gland support plate 21 , and the gland assembly includes a gland head fixing plate 26 , and two ends of the gland head fixing plate 26 are respectively connected and fixed to the two gland support plates 21 .

[0048] A second motor 27 is installed on one side of the capping head fixing plate 26, and two pairs of third slide rails 28 parallel to each other are installed on the other side. The capping pressing plate 29 is installed on the third slide rails 28 and is connected to the sliders 2801 of the two pairs of third slide rails 28. The capping pressing plate 29 can perform vertical lifting movement along the third slide rails 28.

[0049] A first sensor 30 is also installed on the capping head fixing plate 26 , and when the capping pressing plate 29 rises to a certain position, it is detected by the first sensor 30 .

[0050] The capping plate 29 is also provided with a first rack 31 , and the second motor 27 is provided with a first gear 32 . The first gear 32 and the first rack 31 form a gear-rack transmission mechanism. The capping plate 29 can be raised or pressed down by controlling the rotation of the second motor 27 .

[0051] A cover grabbing bottom plate 33 is also installed below the capping head fixing plate 26, and the two sides of the cover grabbing reinforcement plate 34 are respectively connected to the capping head fixing plate 26 and the cover grabbing bottom plate 33. The cover grabbing bottom plate 33 is also installed with a fourth slide rail 73, and two cover grabbing claws 35 are respectively connected to a slider 7301 on the fourth slide rail 73, and the two cover grabbing claws 35 can move along the fourth slide rail 73 to form a clamping mechanism.

[0052] A cover grabbing claw piece 35 is also provided with a cover grabbing push plate 36 and a cover grabbing spring pressure plate 37 . A spring 38 is sandwiched between the cover grabbing spring pressure plate 37 and the cover grabbing reinforcement plate 34 . Under the elastic force of the spring 38 , the cover grabbing claw piece 35 is pushed outwards.

[0053] The cover pressing plate 29 is also provided with two cover grabbing pillars 39 with second bearings 40 installed on their top ends. The second bearings 40 are in contact with the cover grabbing push plate 36. When the second bearings 40 move up and down with the cover pressing plate 29, the second bearings 40 also cause the cover grabbing claws 35 to close inwards, thereby clamping the cover 9.

[0054] The capping assembly is also provided with a first outer cover plate 70, a second outer cover plate 71 and a third outer cover plate 72 for protecting the internal structure of the capping head and for decoration.

[0055] The two ends of the consumable assembly are respectively supported on the second support plate 3 and the third support plate 4. Specifically, the consumable assembly includes a consumable fixing bottom plate 41, and two edges of the consumable fixing bottom plate 41 are respectively fixed on the second support plate 3 and the third support plate 4.

[0056] The first baffle 42, the second baffle 43 and the third baffle 44 are respectively installed on the left and right sides and the back of the consumable fixing bottom plate 41. The first baffle 42 and the second baffle 43 are provided with a groove 4201 and a ball-shaped hole 4202. A ball-shaped screw 45 is installed in the ball-shaped hole 4202. The consumable box 46 is provided with a convex edge 4601 and a second positioning hole 4602. When the consumable box 46 is pushed in from the front, the convex edge 4601 on the consumable box 46 is just located in the groove 4201. After the consumable box 46 is pushed in place, the head of the ball-shaped screw 45 is just located at the second positioning hole 4602 of the consumable box 46, so that the position of the consumable box 46 is fixed, and it will not shake back and forth or left and right, and will not be lifted when the claw takes the cover.

[0057] The consumable box 46 is also designed with two first square holes 4603 , and the consumable fixing bottom plate 41 is also designed with two second square holes 4101 . When the consumable box 46 is put in place, the first square holes 4603 are just aligned with the second square holes 4101 .

[0058] The top cover assembly includes a lifting member 47, which is located below the second square hole 4101. The lifting member 47 is mounted on a fifth slide rail 48 and can move up and down along the fifth slide rail 48. The fifth slide rail 48 is mounted on a lifting fixing plate 49, and the lifting fixing plate 49 is vertically mounted below the consumable fixing bottom plate 41. When the lifting member 47 rises, the lifting member passes through the second square hole 4101 and the first square hole 4603 to lift the cover 9 in the consumable box 46 upward.

[0059] A third motor 50 is also installed under the consumable fixing base plate 41. The second gear 51 on the third motor 50 and the second rack 52 fixed on the lifting member 47 form a gear rack motion mechanism. The lifting member 47 is raised and lowered by controlling the third motor 50. When the lifting member 47 is lowered to the lowest position, it will be detected by the second sensor 53 installed at the bottom of the lifting fixing plate 49.

[0060] A drag chain support 56 is also installed above the third baffle 44, and a drag chain connecting plate 57 is also installed on the pressure head fixing plate 26. The two ends of the drag chain 58 are respectively fixed on the drag chain support 56 and the drag chain connecting plate 57. The control line of the first control circuit board 59 on the pressure cover assembly passes through the third hole 5601 on the drag chain 58 and the drag chain support 56 and is connected to the third control circuit board 60 fixed on the jacking fixing plate 49 below.

[0061] A second control circuit board 61 is also installed under the consumable fixing base plate 41 to control the first motor 22 and the third motor 50. The second control circuit board 61 is also connected to the third control circuit board 60. The third control circuit board 60 is then communicated with other external devices through a connector 62 installed on the third support plate 4.

[0062] A fourth sensor 63 is also installed on the second support plate 3, and a second baffle 64 is installed at a corresponding position on the slide rail connector 11. The second baffle 64 is within the detection range of the fourth sensor 63. The second baffle 64 moves with the slide rail connector 11. When the slide rail connector 11 moves to the maximum position, the second baffle 64 just moves out of the detection range of the fourth sensor 63. When the upper micro-well plate 6 is not placed correctly, the limit plate 13 is blocked by the micro-well plate 6 and cannot move to the correct position, and the second baffle 64 moving synchronously with it cannot move out of the detection range of the fourth sensor 63, thereby reminding the operator that the micro-well plate 6 is not placed correctly.

[0063] The working process of the capping device provided in the present application is as follows: the operator puts in the consumable box 46 with the cover 9, the first motor 22 works to move the capping assembly to the position aligned with the cover 9, the third motor 50 works to lift the cover 9 to be close to the cover grabbing bottom plate 33, and then the second motor 27 works to raise the capping pressing plate 29, driving the second bearing 40 to move upward, so that the cover grabbing claw piece 35 closes and grabs the top cover 9, and then the lifting piece 47 descends to make the remaining covers 9 descend to the lowest position together, and then the first motor 22 works to move the capping assembly to the position aligned with the microwell plate 6, the second motor 27 works to make the capping pressing plate 29 descend a distance, the cover grabbing claw piece 35 opens to make the cover 9 fall on the microwell plate 6, the capping assembly moves again to align the capping pressing plate 29 with the first row of the microwell plate 6, the capping pressing plate 29 is pressed down to press the cover 9 into the microwell plate 6, and the entire microwell plate 6 is pressed in sequence, the capping assembly moves to the rightmost end, and the operator or the matching manipulator takes away the covered microwell plate 6, and the process is completed.

[0064] The capping platform 5 is also designed with an eight-tube capping position 502. When the eight-tube needs to be capped, an external manipulator clamps the eight-tube 81 and the eight-tube cover 82 and places them at the eight-tube capping position. Then the capping assembly moves to the eight-tube capping position, and the capping plate 29 presses down to press the eight-tube cover 82 into the eight-tube 81. The capping plate 29 rises, and the capping assembly moves to the rightmost end. The external manipulator takes away the capped eight-tube, and the eight-tube capping is completed.

[0065] The embodiments of the present application are described above in conjunction with the accompanying drawings, but the present application is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Under the guidance of the present application, ordinary technicians in this field can also make many forms without departing from the purpose of the present application and the scope of protection of the claims, all of which are within the protection of the present application.

Claims

1. A capping device, characterized in that: It includes a capping platform, a consumable assembly, a top cover assembly, a transfer assembly and a capping assembly. The capping platform is provided with a groove, in which a microplate is placed; the consumable assembly is arranged beside the capping platform and is used to place a consumable box, in which a lid is placed; the top cover assembly is arranged below the consumable assembly and is used to lift up a lid on the consumable assembly; the capping assembly is installed on the transfer assembly, the capping assembly grabs the lifted lid, the capping assembly moves upward to grab the lid, the transfer assembly drives the capping assembly to be transferred horizontally to above the capping platform, and the capping assembly moves downward to place and press the grabbed lid on the reaction hole of the microplate to seal the microplate.

2. The capping device according to claim 1, characterized in that: The invention also includes a base, which includes a bottom plate, on which a first support plate, a second support plate and a third support plate for support are installed, the first support plate, the second support plate and the third support plate are arranged in parallel and spaced apart in sequence, the two ends of the pressure cover platform are respectively supported on the first support plate and the second support plate, and the two ends of the consumable assembly are respectively supported on the second support plate and the third support plate.

3. The capping device according to claim 1, characterized in that: A pressure cover pad is laid on the micro-well plate, a plurality of reaction holes are opened on the micro-well plate, a plurality of through holes are opened on the pressure cover pad, the through holes are arranged in one-to-one correspondence with the reaction holes, and the aperture of the reaction hole is smaller than the aperture of the through hole.

4. The capping device according to claim 3, characterized in that: Two cover plates are also installed on the capping platform. The two cover plates are located on opposite sides of the groove, and the inner edges of the cover plates are aligned with the edges of the groove. The edges of the cover plates are processed with bevels, which serve as guides when placing the microplate.

5. The capping device according to claim 3, characterized in that: A positioning structure is also provided on the cover pressing platform, and the positioning structure includes two pairs of slide rails symmetrically installed under the cover pressing platform, a slide rail connector installed on the slide rail, a limit connector symmetrically installed on the slide rail connector, a limit plate installed on the limit connector, a limit rotating part installed in the middle of the bottom surface of the cover pressing platform and a limit connecting rod installed on the slide rail connector, wherein the limit rotating part is provided with a first bearing, the rotating shaft passes through the first bearing and is fixed on the cover pressing platform, the limit rotating part rotates around the rotating shaft, and a roller is also installed on the limit connecting rod, and the roller is simultaneously located in a U-shaped groove on the limit rotating part, and when the limit rotating part rotates, the roller also follows the movement, so that the two limit plates located on both sides of the groove on the cover pressing platform move toward the middle at the same time, so as to assist in positioning the cover.

6. The capping device according to claim 1, characterized in that: The consumable assembly includes a consumable fixing base plate, the two edges of which are respectively fixed on the second support plate and the third support plate, the first baffle, the second baffle and the third baffle are respectively installed on the left and right sides and the back of the consumable fixing base plate, the first baffle and the second baffle are both provided with grooves and ball-shaped holes, ball-shaped screws are installed in the ball-shaped holes, the consumable box is provided with a convex edge and a second positioning hole, when the consumable box is pushed in from the front, the convex edge on the consumable box is just located in the groove, after the consumable box is pushed into place, the head of the ball-shaped screw is just located at the second positioning hole of the consumable box, the consumable box is also designed with two first square holes, and the consumable fixing base plate is also designed with two second square holes, when the consumable box is placed in place, the first square hole is just aligned with the second square hole.

7. The capping device according to claim 6, characterized in that: The top cover assembly includes a lifting member, which is located below the second square hole. The lifting member is installed on the fifth slide rail and can move up and down along the fifth slide rail. The fifth slide rail is installed on a lifting fixing plate, and the lifting fixing plate is vertically installed below the consumable fixing bottom plate. When the lifting member rises, the lifting member passes through the second square hole and the first square hole to lift the cover in the consumable box upward.

8. The capping device according to claim 2, characterized in that: The transfer assembly includes a second slide rail and a first motor, a connecting plate is installed on the second slide rail, a gland support plate is installed on both sides of the connecting plate, and the connecting plate and the gland support plate can move along the second slide rail; the first motor is installed on the base plate, and the first synchronous pulley and the first tensioning pulley on the first motor are connected by a synchronous belt to form a synchronous belt transmission structure, the connecting plate is connected to the synchronous belt, and the connecting plate can be moved along the second slide rail by controlling the forward and reverse rotation of the first motor, and the gland assembly is installed on the gland support plate.

9. The capping device according to claim 1, characterized in that: The capping assembly includes a capping head fixing plate, a second motor is installed on one side of the capping head fixing plate, and two third slide rails parallel to each other are installed on the other side. The capping pressing plate is installed on the third slide rail and connected to the sliders of the two third slide rails. The capping pressing plate can perform vertical lifting movement along the third slide rail, and the capping pressing plate is used to press the cover into the reaction hole on the microwell plate; a cap grabbing base plate is also installed under the capping head fixing plate, and the two sides of the cap grabbing reinforcement plate are respectively connected to the capping head fixing plate and the cap grabbing base plate, and the cap grabbing base plate is also installed with a fourth slide rail, and two cap grabbing claws are respectively connected to a slider on the fourth slide rail, and the two cap grabbing claws can move along the fourth slide rail to form a clamping mechanism, and the clamping mechanism is used to grab the cover.

10. The capping device according to claim 9, characterized in that: The cover grabbing claw piece is also equipped with a cover grabbing push plate and a cover grabbing spring pressure plate, and a spring is clamped between the cover grabbing spring pressure plate and the cover grabbing reinforcement plate. Under the elastic force of the spring, the cover grabbing claw piece is pushed outward; two cover grabbing pillars are also installed on the cover pressing plate, and a second bearing is installed on the top of the cover grabbing pillar. The second bearing is in contact with the cover grabbing push plate. When the second bearing moves up and down with the cover pressing plate, the second bearing also causes the cover grabbing claw piece to close inward to clamp the cover or open to place the cover.

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