A dispersing device for producing pharmaceutical intermediates

Abstract

The utility model relates to a dispersing device for producing drug intermediates, including a tank body and a stirring mechanism, and also includes: a detection mechanism, which includes a detection chamber and a pH meter probe, wherein the detection chamber is connected to the tank body, and the probe end of the pH meter probe is arranged in the detection chamber; a sampling mechanism, which includes a liquid inlet pipe, a liquid extraction component, a liquid outlet pipe and a plurality of sampling tubes, wherein the sampling tube is connected between the liquid inlet pipe and the tank body, the liquid extraction component is arranged on the outside of the tank body, and the liquid in the tank body is drained into the detection chamber through the liquid inlet pipe, the sampling tube and the liquid outlet pipe, and the plurality of sampling tubes all have a valve body, and are distributed equidistantly from top to bottom. The dispersing device for producing drug intermediates is designed with sampling tubes distributed equidistantly from top to bottom, and only needs to design a set of pH meter probes for fixed-point detection to perform pH detection on liquids at different depths in the tank body, so as to reflect whether the solution of the drug intermediate is fully reacted, and ensure the accuracy of the pH detection result.

Description

Technical Field

[0001] The utility model relates to the technical field of drug intermediate production, in particular to a dispersing device for producing drug intermediates. Background Art

[0002] 2-Hydroxypyridine-N-oxide (HOPO) is a drug intermediate and can be widely used in combination with EDC 1 in the synthesis of peptide drugs, antiviral drugs and other amide-containing drugs because of its mild reaction conditions, high yield and ability to racemize byproducts.

[0003] Based on the above, it can be seen that HOPO has a considerable demand as a drug intermediate. In the preparation or production of HOPO drug intermediates, for example, the pH value of the liquid needs to be accurately controlled. In the prior art, in order to understand the pH value of the liquid in the reactor, the existing stirring device usually designs a pH detection probe to detect the pH of the liquid in the stirring container (such as a reactor). However, the stirring process may not be fully stirred due to insufficient stirring time or inaccurate temperature control (workers cannot observe whether it is fully stirred by naked eyes alone). At this time, the pH values ​​of the liquid at different depths in the stirring container are different, and the pH detection probe can only detect the pH of the liquid at a single depth, which will mislead the detection result. For this reason, a dispersion device for producing drug intermediates is proposed. Utility Model Content

[0004] The utility model provides a dispersing device for producing drug intermediates, which can effectively detect the pH value of liquids at different depths in a tank body, and can reflect whether the solution has reacted sufficiently, thereby ensuring the accuracy of the pH detection result. In addition, it can facilitate water replenishment and cleaning in the tank body.

[0005] The utility model solves the above technical problems with the following technical solutions: A dispersing device for producing drug intermediates, including a tank body and a stirring mechanism, and also including:

[0006] The detection mechanism comprises a detection chamber and a pH meter probe, wherein the detection chamber is connected to the tank body, and a probe end of the pH meter probe is arranged in the detection chamber;

[0007] The sampling mechanism includes a liquid inlet pipe, a liquid extraction component, a liquid outlet pipe and a plurality of sampling tubes, wherein the sampling tube is connected between the liquid inlet pipe and the tank body, the liquid extraction component is arranged on the outside of the tank body, and the liquid in the tank body is drained into the detection chamber through the liquid inlet pipe, the sampling tube and the liquid outlet pipe. The plurality of sampling tubes all have a valve body and are distributed in equal distances from top to bottom, so that the pH meter probe can detect liquids at different depths in the tank body.

[0008] On the basis of the above technical solution, the present invention can also be improved as follows.

[0009] Furthermore, a liquid return port is provided on the tank body, the detection chamber is arranged above the liquid return port, a liquid return pipe is provided between the detection chamber and the liquid return port, and a valve body 2 is provided on the outer side of the liquid return pipe.

[0010] Furthermore, it also includes a cleaning pipe, which is connected to the liquid inlet pipe, and a valve body three is arranged on the outside of the cleaning pipe.

[0011] Furthermore, a stepped surface is provided on the outer side of the tank body, a support frame is provided on the stepped surface, and the liquid extraction component is arranged on the outer side of the tank body through the support frame.

[0012] Furthermore, the liquid pumping component is a liquid pump, the liquid pumping port of the liquid pump is connected to the liquid inlet pipe, the liquid outlet of the liquid pump is connected to the liquid outlet pipe, and the liquid pump is fixed to the support frame by bolts.

[0013] Furthermore, a filter screen is provided on the side of the sampling tube away from the liquid inlet pipe, so that the crystals or granular materials in the tank body can be intercepted.

[0014] Furthermore, a mounting hole is provided on the detection chamber, and the pH meter probe is arranged on the detection chamber through the mounting hole, and the pH meter probe terminal is located above the detection chamber.

[0015] Furthermore, the stirring mechanism includes a motor, a stirring shaft and a stirring frame, wherein the motor is arranged on the tank body, the stirring shaft is rotatably connected to the center of the tank body and connected to the output end of the motor, and the stirring frame is located in the tank body and connected to the stirring shaft.

[0016] Furthermore, it also includes four groups of supporting legs, which are distributed on the outside of the tank body in a circular array to support the tank body.

[0017] Compared with the prior art, the technical solution of this application has the following beneficial technical effects:

[0018] The dispersing device for producing drug intermediates is designed with sampling tubes distributed equidistantly from top to bottom. Only a set of fixed-point detection pH meter probes need to be designed to perform pH detection on liquids at different depths in the tank to reflect whether the solution for producing drug intermediates has reacted sufficiently, thereby ensuring accurate pH detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 A schematic diagram of the structure of a dispersing device for producing a pharmaceutical intermediate provided in an embodiment of the utility model;

[0020] Figure 2 for Figure 1 A structural diagram from another perspective;

[0021] Figure 3A schematic diagram of a half-section structure of an embodiment of the utility model;

[0022] Figure 4 for Figure 3 A partial enlarged schematic diagram of area A in the middle.

[0023] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0024] 1. Tank body; 2. Stirring mechanism; 21. Motor; 22. Stirring shaft; 23. Stirring frame; 3. Detection mechanism; 31. Detection chamber; 32. pH meter probe; 4. Sampling mechanism; 41. Liquid inlet pipe; 42. Liquid extraction component; 43. Liquid outlet pipe; 44. Sampling tube; 45. Valve body 1; 46. Support frame; 47. Filter screen; 5. Liquid return port; 6. Cleaning pipe. DETAILED DESCRIPTION

[0025] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0026] like Figure 1 and Figure 2 As shown, a dispersing device for producing drug intermediates in this embodiment is mainly used for preparing 2-hydroxypyridine-N-oxide intermediates. It can be understood that it can also be used for other drug intermediates that need to be tested for pH. The dispersing device for producing drug intermediates includes a tank body 1, a stirring mechanism 2, a detection mechanism 3 and a sampling mechanism 4, wherein the tank body 1 is used to provide a mixing space for stirring and dispersing the prepared materials, the stirring mechanism 2 is arranged on the tank body 1, and is used to complete the stirring, dispersing and mixing of the materials in the tank body 1, and the sampling mechanism 4 is equivalent to extracting the liquid at different depths in the tank body 1 and sending it to the detection mechanism 3 for detection, so that the dispersing device for producing drug intermediates can effectively perform pH detection on the liquid at different depths in the tank body 1, thereby reflecting whether the liquid solution of the drug intermediate is fully reacted and ensuring that the pH detection result is more accurate.

[0027] Among them, it should be noted that the dispersing device for producing drug intermediates also includes four groups of legs, which are placed on the ground, and the four groups of legs are distributed in a circular array on the outside of the tank body 1, and support the tank body 1 so that the tank body 1 has a height difference with the ground, and the bottom of the tank body 1 is integrally connected with a discharge port, so that it is convenient for subsequent discharge of the tank body 1, and the stirring mechanism 2 includes a motor 21, a stirring shaft 22 and a stirring frame 23, wherein the motor 21 is fixedly arranged on the tank body 1, the stirring shaft 22 can be rotatably connected to the center of the tank body 1, and is connected to the output end of the motor 21, and the stirring frame 23 is located in the tank body 1 and is connected to the stirring shaft 22.

[0028] For ease of understanding, the structure and position of the detection mechanism 3 and the sampling mechanism 4 are explained here.

[0029] Specifically, Figure 2 and 3 As shown, the detection mechanism 3 includes a detection chamber 31 and a pH meter probe 32 , and the sampling mechanism 4 includes a liquid inlet pipe 41 , a liquid extraction component 42 , a liquid outlet pipe 43 and a plurality of sampling tubes 44 .

[0030] Further explanation, the sampling tube 44 in the above structure is specifically arranged horizontally, while the liquid inlet tube 41 is arranged vertically, and the sampling tube 44 is connected between the liquid inlet tube 41 and the tank body 1, so that the liquid in the tank body 1 can enter the liquid inlet tube 41 through the sampling tube 44, and the liquid extraction component 42 is detachably arranged on the outside of the tank body 1, and drains the liquid in the tank body 1 into the detection chamber 31 through the liquid inlet tube 41, the sampling tube 44 and the liquid outlet tube 43, so that the pH meter probe 32 can complete the detection of the drained liquid.

[0031] The pumping component 42 is detachably arranged on the outside of the tank body 1, as shown in FIG. Figure 2 and 3 As shown, a stepped surface is provided on the outer side of the tank body 1, and a support frame 46 is fixedly provided on the stepped surface by bolts. The liquid pumping component 42 is fixedly provided on the outer side of the tank body 1 by this support frame 46. In addition, it should be noted that the liquid pumping component 42 is preferably a liquid pump. At this time, the liquid pumping port of the liquid pump is connected to the liquid inlet pipe 41, and the liquid outlet of the liquid pump is connected to the liquid outlet pipe 43, and the liquid pump is fixed to the support frame 46 by bolts.

[0032] And as Figure 3 As shown, the detection chamber 31 is connected to the tank body 1. At this time, a liquid return port 5 is integrally connected to the tank body 1. The detection chamber 31 is arranged above the liquid return port 5. A liquid return pipe is fixedly arranged between the detection chamber 31 and the liquid return port 5. A valve body 2 is arranged on the outside of the liquid return pipe to control whether the liquid return pipe can be conducted so that the pH meter probe 32 can detect it. It is opened after each detection of the pH meter probe 32 to allow the liquid after detection to return to the tank body 1. The probe end of the pH meter probe 32 is arranged in the detection chamber 31. That is, at this time, a mounting hole is opened on the detection chamber 31 in this embodiment, and a baffle is fixed on the outside of the pH meter probe 32. The diameter of the baffle is larger than the diameter of the mounting hole, and the baffle is fixed to the detection chamber 31 by bolts, so that the pH meter probe 32 is fixedly arranged on the detection chamber 31 through this mounting hole, and the wiring terminal of the pH meter probe 32 is located above the detection chamber 31 to facilitate the subsequent wiring of the pH meter probe 32.

[0033] It should also be noted that several sampling tubes 44 are each provided with a valve body 45 for controlling whether the corresponding sampling tube 44 itself can be conducted. The number of the sampling tubes 44 is preferably six groups, and the six groups of sampling tubes 44 are distributed in equal distances from top to bottom. In this way, workers can drain liquid solutions at different depths in the tank body 1 as needed, allowing the pH meter probe 32 to detect liquids at different depths in the tank body 1.

[0034] When in use, the conduction of the sampling tubes 44 is controlled by the valve body 45, and only one group of sampling tubes 44 is in the conduction state each time. After the sampling and detection of the sampling tubes 44 at this depth is completed, the corresponding PH detection is performed on the sampling tubes 44 at other different depths. In this way, after the PH value of the liquid at different depths is detected by the PH meter probe 32 for multiple times, when the multiple groups of detection results show relatively consistent results, it means that the liquid solution of the production of the drug intermediate is fully mixed, and when the difference in the detection results is too large, it means that the liquid of the production of the drug intermediate is likely to be not fully mixed. When designed in this way, the dispersion device for producing the drug intermediate can effectively detect the PH of the liquid at different depths in the tank body 1, and can reflect whether the solution of the production of the drug intermediate is fully reacted, thereby ensuring the accuracy of the PH detection result.

[0035] Further, in one embodiment, if Figure 4 As shown, a filter screen 47 is fixedly provided on one side of the sampling tube 44 away from the liquid inlet tube 41 so that the crystals or granular materials in the tank body 1 can be intercepted.

[0036] In addition, if Figure 2 and 3 As shown, in order to facilitate water replenishment and cleaning in the tank body 1, the dispersion device for producing drug intermediates also includes a cleaning pipe 6, which is connected to the liquid inlet pipe 41. A valve body three is arranged on the outside of the cleaning pipe 6. The valve body three, the valve body two and the valve body one 45 are preferably solenoid valves. The valve body three is used to control whether the cleaning pipe 6 is conductive, and the cleaning pipe 6 is used to be connected to the water source. In this way, when the valve bodies one 45 are all closed and the valve bodies two and three are opened, starting the liquid pumping component 42 can allow the water source to enter the tank body 1. In this way, mechanized water replenishment is achieved for subsequent cleaning.

[0037] Working principle:

[0038] Only one group of sampling tubes 44 is in the conducting state at a time, and the valve bodies 2 and 3 are ensured to be in the closed state. When any group of sampling tubes 44 is in the conducting state, the liquid pump is started to allow the sampling tubes 44 at that depth to draw the liquid at that depth in the tank body 1 into the detection chamber 31, and the pH meter probe 32 performs detection;

[0039] After the sampling test of the sampling tube 44 at that depth is completed, the valve body 2 is opened to allow the liquid solution in the test chamber 31 to return to the tank body 1. Subsequently, the sampling tubes 44 at other different depths can be subjected to corresponding PH tests in the same manner. In this way, after the PH value of the liquid at different depths is tested multiple times by the PH meter probe 32, when multiple groups of test results show relatively consistent results, it means that the liquid solution of the production drug intermediate is fully mixed. When the test results are too different, it means that the liquid of the production drug intermediate is not easily fully mixed. When designed in this way, the dispersion device for producing drug intermediates can effectively perform PH tests on the liquid at different depths in the tank body 1, and can reflect whether the solution of the production drug intermediate is fully reacted, thereby ensuring accurate PH test results.

[0040] The above are only preferred specific implementation methods of the utility model, but the protection scope of the utility model is not limited to this. Any technician familiar with the technical field within the technical scope disclosed by the utility model, who makes equivalent replacements or changes based on the technical scheme and utility model concept of the utility model, should be covered by the protection scope of the utility model.

Claims

1. A dispersing device for producing a pharmaceutical intermediate, comprising a tank (1) and a stirring mechanism (2), characterized in that: Also includes: A detection mechanism (3), comprising a detection chamber (31) and a pH meter probe (32), wherein the detection chamber (31) is connected to the tank body (1), and a probe end of the pH meter probe (32) is arranged in the detection chamber (31); The sampling mechanism (4) comprises a liquid inlet pipe (41), a liquid extraction component (42), a liquid outlet pipe (43) and a plurality of sampling pipes (44), wherein the sampling pipe (44) is connected between the liquid inlet pipe (41) and the tank body (1), the liquid extraction component (42) is arranged on the outside of the tank body (1), and the liquid in the tank body (1) is drained into the detection chamber (31) through the liquid inlet pipe (41), the sampling pipe (44) and the liquid outlet pipe (43), and the plurality of sampling pipes (44) are all provided with a valve body (45) and are arranged at equal distances from top to bottom, so that the pH meter probe (32) can detect liquids at different depths in the tank body (1).

2. A dispersing device for producing a pharmaceutical intermediate according to claim 1, characterized in that: The tank body (1) is provided with a liquid return port (5), the detection chamber (31) is arranged above the liquid return port (5), a liquid return pipe is arranged between the detection chamber (31) and the liquid return port (5), and a second valve body is arranged outside the liquid return pipe.

3. A dispersing device for producing a pharmaceutical intermediate according to claim 2, characterized in that: It also comprises a cleaning pipe (6), the cleaning pipe (6) is connected to the liquid inlet pipe (41), and a valve body 3 is arranged on the outside of the cleaning pipe (6).

4. A dispersing device for producing a pharmaceutical intermediate according to claim 3, characterized in that: The outer side of the tank body (1) is provided with a stepped surface, and a support frame (46) is provided on the stepped surface. The liquid extraction component (42) is arranged on the outer side of the tank body (1) via the support frame (46).

5. A dispersing device for producing a pharmaceutical intermediate according to claim 4, characterized in that: The liquid pumping component (42) is a liquid pump, the liquid pumping port of the liquid pump is connected to the liquid inlet pipe (41), the liquid outlet of the liquid pump is connected to the liquid outlet pipe (43), and the liquid pump is fixed to the support frame (46) by bolts.

6. A dispersing device for producing a pharmaceutical intermediate according to claim 5, characterized in that: A filter screen (47) is provided on the side of the sampling tube (44) away from the liquid inlet tube (41) so that crystals or granular materials in the tank body (1) can be intercepted.

7. A dispersing device for producing a pharmaceutical intermediate according to claim 1, characterized in that: The detection chamber (31) is provided with a mounting hole, and the pH meter probe (32) is arranged on the detection chamber (31) through the mounting hole, and the connection terminal of the pH meter probe (32) is located above the detection chamber (31).

8. A dispersing device for producing a pharmaceutical intermediate according to claim 1, characterized in that: The stirring mechanism (2) comprises a motor (21), a stirring shaft (22) and a stirring frame (23), wherein the motor (21) is arranged on the tank body (1), the stirring shaft (22) is rotatably connected to the center of the tank body (1) and is connected to the output end of the motor (21), and the stirring frame (23) is located in the tank body (1) and is connected to the stirring shaft (22).

9. A dispersing device for producing a pharmaceutical intermediate according to claim 1, characterized in that: It also includes four groups of supporting feet, which are distributed in a circular array on the outside of the tank body (1) and support the tank body (1).

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