Gene sequencer and sequencing chip processing device

Abstract

The utility model discloses a gene sequencer and a sequencing chip processing device, wherein the gene sequencer includes a frame, a chip motion platform, a liquid circuit system and an optical system. The chip motion platform includes a motion seat and a motion seat driving mechanism for driving the motion seat; the motion seat is movably arranged on the frame to drive the sequencing chip to move; the liquid circuit system includes a first rotary valve arranged on the motion seat, and the liquid circuit system also includes a chip liquid supply pipeline connected between the first rotary valve and the sequencing chip. By arranging the first rotary valve in the liquid circuit system on the motion seat, the first rotary valve arranged on the motion seat can move with the sequencing chip during the process of the motion seat driving the sequencing chip to move, so that the redundant length required for the chip liquid supply pipeline between the first rotary valve and the sequencing chip is small, thereby reducing the redundant design and reducing the loss of reagents.

Description

Technical Field

[0001] The utility model relates to the technical field of gene sequencing, and in particular to a gene sequencer and a sequencing chip processing device. Background Art

[0002] Gene sequencing equipment can identify and sort the base sequence of sample DNA. Current sequencers usually include a chip platform, and the sequencing chip is installed on the chip platform. The sequencer includes a liquid system, and the liquid system provides samples and / or reagents to the sequencing chip. Due to the large variety of samples and reagents, in order to simplify the pipeline of the liquid system, the liquid system usually includes a rotary valve, and the liquid flowing out of the rotary valve enters the sequencing chip. The rotary valve can switch the type of liquid flowing into the sequencing chip. During the sequencing process of the sequencing chip, it is necessary to take a picture of the chip. When taking pictures, the chip platform needs to move with the chip. In order to ensure that the liquid pipeline between the rotary valve and the sequencing chip adapts to the position of the sequencing chip, the liquid pipeline between the rotary valve and the sequencing chip usually needs to have a redundant length, and the excessive redundant length causes excessive reagent loss, and there is a technical problem of large reagent loss. Utility Model Content

[0003] The present application provides a gene sequencer and a sequencing chip processing device, which are used to solve the technical problem of large reagent loss in current gene sequencers.

[0004] In one embodiment, a gene sequencer is provided, comprising:

[0005] frame;

[0006] The chip motion platform comprises a motion seat and a motion seat driving mechanism for driving the motion seat; the motion seat is movably arranged on the frame and is used to drive the sequencing chip to move;

[0007] A liquid circuit system, the liquid circuit system is connected to the sequencing flow channel of the sequencing chip; the liquid circuit system includes a first rotary valve disposed on the motion seat, the first rotary valve is used to select a target sample and / or a target reagent to be injected into the sequencing flow channel; the liquid circuit system also includes a chip liquid supply pipeline connected between the first rotary valve and the sequencing chip;

[0008] and an optical system for photographing and imaging the sequencing flow channel.

[0009] In one embodiment, the liquid circuit system includes a second rotary valve; at least part of the liquid inlet of the first rotary valve is connected to the second rotary valve, so that the second rotary valve supplies liquid to the first rotary valve, the sequencer includes a rotary valve seat movably configured on the frame, the second rotary valve is configured on the rotary valve seat, the sequencer includes a valve seat driving mechanism for driving the rotary valve seat to move, and the gene sequencer includes a control system, the control system is connected to the motion seat driving mechanism and to the valve seat driving mechanism, so as to control the rotary valve seat to follow the movement of the motion seat.

[0010] In one embodiment, the moving seat is configured on the frame to move along a first direction, the rotating valve seat is configured on the frame to move along the first direction, and the control system controls the rotating valve seat to move along with the moving seat in the first direction.

[0011] In one embodiment, the gene sequencer includes a chip seat, which is moved along a second direction and configured on the moving seat, and the chip seat is used to install the sequencing chip. The angle between the first direction and the second direction is greater than 0 degree and not greater than 90 degrees, and the first direction is consistent with the extension direction of the sequencing channel; during the sequencing process of the sequencing chip, the moving distance of the moving seat in the first direction is greater than the moving distance of the chip seat in the second direction, and the rotary valve seat can only reciprocate along the first direction.

[0012] In one embodiment, the rotary valve seat is located on an upper side of the first rotary valve.

[0013] In one embodiment, the valve seat driving mechanism includes a driving wheel, a driven wheel and a transmission belt, the driving wheel and the driven wheel are arranged at intervals along a first direction, the transmission belt is wound around the driving wheel and the driven wheel, and the rotating valve seat is connected to the transmission belt so that the driving wheel can drive the rotating valve seat to move through the transmission belt.

[0014] In one embodiment, the frame includes a column and a longitudinal beam fixed on the column, the longitudinal beam extends along the first direction, the rotary valve seat is movably configured on the longitudinal beam, and the valve seat driving mechanism includes a driving motor; in the first direction, the driving motor is located on one side of the column, and the second rotary valve is always located on the other side of the column.

[0015] In one embodiment, the moving seat is moved along a first direction and configured on the frame, the gene sequencer includes a chip seat, the chip seat is moved along a second direction and configured on the moving seat, the chip seat is used to install the sequencing chip, the angle between the first direction and the second direction is greater than 0 degrees and not greater than 90 degrees, at least one of the first rotary valves is installed on the moving seat and / or at least one of the first rotary valves is installed on the chip seat.

[0016] In one embodiment, a sequencing chip processing device is provided, comprising:

[0017] frame;

[0018] The chip motion platform comprises a motion seat and a motion seat driving mechanism, wherein the motion seat is used to drive the sequencing chip to move, the motion seat is movably arranged on the frame, and the motion seat driving mechanism is used to drive the motion seat to move;

[0019] and a first rotary valve, wherein the first rotary valve is used to select a target sample and / or a target reagent and inject it into a sequencing channel of a sequencing chip; the sequencing chip processing device also includes a chip liquid supply pipeline connected between the first rotary valve and the sequencing chip; the first rotary valve is arranged on the moving seat.

[0020] In one embodiment, the sequencing chip processing device includes a second rotary valve; part of the liquid inlet of the first rotary valve is connected to the second rotary valve so that the second rotary valve supplies liquid to the first rotary valve, the sequencing chip processing device includes a rotary valve seat movably configured on the frame, the second rotary valve is configured on the rotary valve seat, the sequencing chip processing device includes a valve seat driving mechanism for driving the rotary valve seat to move, and the sequencing chip processing device includes a control system, the control system is connected to the moving seat driving mechanism and to the valve seat driving mechanism, so as to control the rotary valve seat to follow the movement of the moving seat.

[0021] According to the gene sequencer and sequencing chip processing device of the above-mentioned embodiment, by configuring the first rotary valve in the liquid path system on the moving seat, when the moving seat drives the sequencing chip to move, the first rotary valve configured on the moving seat can move with the sequencing chip. In this way, the redundant length required for the chip liquid supply pipeline between the first rotary valve and the sequencing chip is small, thereby reducing the redundant design, reducing the loss of reagents, and solving the technical problem of large reagent loss in the current gene sequencer. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of the chip motion platform in an embodiment;

[0023] Figure 2A schematic diagram of the structure of the chip motion platform at another viewing angle in one embodiment;

[0024] Figure 3 A top view of the chip moving platform in one embodiment;

[0025] Figure 4 For along Figure 3 Sectional view of AA in the middle;

[0026] Figure 5 for Figure 3 Left view of

[0027] Figure 6 The figure is a schematic diagram of the liquid circuit of a gene sequencer in one embodiment.

[0028] The reference numerals are as follows:

[0029] 1-frame; 11-column; 12-longitudinal beam; 2-chip motion platform; 21-motion seat; 22-chip seat; 221-sequencing chip installation station; 3-liquid system; 31-chip liquid supply pipeline; 32-first rotary valve; 321-liquid interface; 33-second rotary valve; 331-liquid interface; 34-liquid supply pipeline; 35-liquid inlet block; 36-liquid outlet block; 37-injection pump; 38-manifold block; 39-waste liquid barrel; 4-sequencing chip; 41-sequencing flow channel; 5-test kit; 6-rotating valve seat; 61-crossbeam; 62-fixed frame; 7-valve seat drive mechanism; 71-driving wheel; 72-driven wheel; 73-transmission belt; 74-driving motor; 8-guide rail. DETAILED DESCRIPTION

[0030] The present invention is further described in detail below by specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments adopt associated similar element numbers. In the following embodiments, many detailed descriptions are intended to enable the present application to be better understood. However, those skilled in the art can easily recognize that some of the features can be omitted in different situations, or can be replaced by other elements, materials, and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by too much description, and for those skilled in the art, it is not necessary to describe these related operations in detail, and they can fully understand the related operations based on the description in the specification and the general technical knowledge in the art.

[0031] In addition, the features, operations or characteristics described in the specification can be combined in any appropriate manner to form various implementations. At the same time, the steps or actions in the method description can also be interchanged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the various sequences in the specification and the drawings are only for the purpose of clearly describing a certain embodiment and are not meant to be a required sequence, unless otherwise specified that a certain sequence must be followed.

[0032] The serial numbers of the components in this document, such as "first", "second", etc., are only used to distinguish the objects described and do not have any order or technical meaning. The "connection" and "coupling" mentioned in this application, unless otherwise specified, include direct and indirect connections (couplings).

[0033] In current gene sequencers, in order to adapt to the movement of the sequencing chip, the pipeline between the rotary valve and the sequencing chip usually needs to be designed with a long redundant length, resulting in a large loss of reagents. In the gene sequencer proposed in this application, the length of the chip liquid supply pipeline between the first rotary valve and the sequencing chip is shortened by configuring the first rotary valve on the motion seat.

[0034] In one embodiment, please refer to Figures 1 to 6 The gene sequencer includes a frame 1, a chip motion platform 2, a liquid system 3 and an optical system.

[0035] The optical system is used to take pictures and images of the sequencing flow channel 41. The chip motion platform 2 is used to carry the sequencing chip 4 (please refer to Figure 6 ), and drives the sequencing chip 4 to move so as to take pictures of the analytes in the multiple sequencing channels 41 in the sequencing chip 4 in sequence. The sequencing chip 4 is a flat structure, and the top surface of the sequencing chip 4 is provided with multiple parallel sequencing channels 41. An inlet is provided at one end of the sequencing chip 4, and an outlet is provided at the other end. Each sequencing channel 41 can be provided with an inlet and an outlet respectively, or multiple sequencing channels 41 can share an inlet and an outlet. The sequencing channel 41 is used to provide a place for the reaction or incubation of the analyte. For example, in the gene sequencing process, the sequencing channel 41 provides a place for the reaction of biological samples and reagents. The chip motion platform 2 includes a motion seat 21 and a motion seat driving mechanism for driving the motion seat 21. The motion seat 21 is movably configured on the frame 1 to drive the sequencing chip 4 to move. In one embodiment, the motion seat 21 is configured on the frame 1 to move along a first direction, and the motion seat driving mechanism can adopt a gear rack driving mechanism, a lead screw nut driving mechanism, a linear motor or a driving cylinder and other driving mechanisms.

[0036] The liquid system 3 is connected to the sequencing flow channel 41 of the sequencing chip 4, and liquid can be supplied to the sequencing chip 4 through the liquid system 3. The liquid system 3 includes a chip liquid supply pipeline 31 (please refer to Figure 6) and a first rotary valve 32. The first rotary valve 32 is disposed on the motion seat 21 and is used to select a target sample and / or a target reagent and inject it into the sequencing flow channel 41. The chip liquid supply pipeline 31 is used to connect between the first rotary valve 32 and the sequencing chip 4.

[0037] Since the first rotary valve 32 is arranged on the moving seat 21, when the moving seat 21 drives the sequencing chip 4 to move, the first rotary valve 32 arranged on the moving seat 21 can move with the sequencing chip 4, so that the redundant length required for the chip liquid supply pipeline 31 between the first rotary valve 32 and the sequencing chip 4 is small, thereby reducing the redundant design and reducing the loss of reagents.

[0038] In the present application, there are many situations in which the first rotary valve 32 is arranged on the moving seat 21. For example, in one embodiment, the first rotary valve 32 and the sequencing chip 4 are relatively fixed. When the sequencing chip 4 moves, the first rotary valve 32 moves synchronously with the sequencing chip 4. For another example, in one embodiment, the moving seat 21 is movably provided with a chip seat 22 and a chip seat driving mechanism for driving the chip seat 22 to move. The chip seat 22 is used to install the sequencing chip 4. The first rotary valve 32 is fixed on the moving seat 21. When the chip seat 22 drives the sequencing chip 4 to move, there is still relative movement between the first rotary valve 32 and the sequencing chip 4. When the moving seat 21 drives the sequencing chip 4 to move, the first rotary valve 32 moves with the chip seat 22. The sequencing chip 4 is arranged on the moving seat 21, including the situation in which the sequencing chip 4 is directly installed on the moving seat 21, and also includes the situation in which the sequencing chip 4 is indirectly installed on the moving seat 21, that is, it is installed on the moving seat 21 through the chip seat 22.

[0039] In one embodiment, please refer to Figure 1 The chip holder 22 is moved along the second direction and arranged on the moving holder 21, and the chip holder driving mechanism drives the chip holder 22 to move along the second direction. Since the moving holder driving mechanism can drive the moving holder 21 to move along the first direction, the chip holder 22 can move along both the first direction and the second direction. Figure 4 and Figure 5 The motion seat 21 and the chip seat 22 form a cross slide. The chip seat drive mechanism can be a gear rack drive mechanism, a lead screw nut drive mechanism, a linear motor or a drive cylinder.

[0040] It should be noted that in the present application, the chip seat 22 is configured on the moving seat 21. The moving seat 21 can drive the chip seat 22 to move while moving. Therefore, when the moving seat 21 moves relative to the frame 1, the chip seat 22 also moves relative to the frame 1. When the chip seat 22 moves relative to the moving seat 21, it also moves relative to the frame 1.

[0041] In one embodiment, please refer to Figure 1 and Figure 6 The liquid circuit system 3 includes a second rotary valve 33, and the liquid circuit interface 321 of the first rotary valve 32 includes a liquid inlet and a liquid outlet, wherein the liquid outlet is connected to the chip liquid supply pipeline 31, and at least part of the liquid inlet of the first rotary valve 32 is connected to the second rotary valve 33, so that the second rotary valve 33 can supply liquid to the first rotary valve 32. In one embodiment, please refer to Figure 6 Part of the liquid inlets of the first rotary valve 32 are directly connected to the reagent kit 5 , so that the reagent or sample is directly supplied to the sequencing chip 4 through the first rotary valve 32 . In another embodiment, all the liquid inlets of the first rotary valve 32 are connected to the second rotary valve 33 .

[0042] The sequencer includes a rotary valve seat 6 movably disposed on a frame 1 and a valve seat driving mechanism 7 for driving the rotary valve seat 6 to move, and the second rotary valve 33 is disposed on the rotary valve seat 6. In one embodiment, the rotary valve seat 6 is movably disposed on the frame 1 along a first direction, and the valve seat driving mechanism 7 can be a driving mechanism such as a cylinder or a linear motor.

[0043] The gene sequencer includes a control system, which is connected to the motion seat drive mechanism and the valve seat drive mechanism 7 to control the rotary valve seat 6 to follow the motion seat 21 .

[0044] The rotary valve seat 6 is movably arranged on the frame 1 and can move with the moving seat 21. The second rotary valve 33 is arranged on the rotary valve seat 6. When the moving seat 21 drives the sequencing chip 4 and the first rotary valve 32 to move, the valve seat driving mechanism 7 can drive the second rotary valve 33 on the rotary valve seat 6 to move with the moving seat 21, thereby shortening the length of the liquid supply pipeline 34 between the second rotary valve 33 on the rotary valve seat 6 and the first rotary valve 32, thereby reducing reagent loss.

[0045] It should be noted that in the present application, the rotating valve seat 6 follows the movement of the moving seat 21, which not only includes the synchronous movement of the rotating valve seat 6 and the moving seat 21, but also includes the synchronous movement of the rotating valve seat 6 and the moving seat 21 in a certain direction, and relative movement in other directions. It can be understood that the rotating valve seat 6 follows the movement of the moving seat 21, which can be synchronous or asynchronous. Compared with the situation where the rotating valve seat 6 is fixed and does not follow the movement of the moving seat 21, when following asynchronously, the distance between the rotating valve seat 6 and the moving seat 21 can gradually increase, but the increase speed is slow, which can also reduce the redundant length of the chip liquid supply pipeline 31. Of course, asynchronous following also includes the situation where the distance between the rotating valve seat 6 and the moving seat 21 becomes smaller. At this time, the movement speed of the rotating valve seat 6 can be greater than the movement speed of the moving seat 21 at certain times.

[0046] The control system controls the rotating valve seat 6 in such a way that, since the control system is connected to the valve seat drive mechanism 7 and the moving seat drive mechanism, the control system controls the operation of the valve seat drive mechanism 7 and the moving seat drive mechanism at the same time, thereby controlling the movement of the moving seat 21 and the rotating valve seat 6. For example, when the moving seat 21 needs to move in a first direction, the control system controls the moving seat drive mechanism to work, driving the moving seat 21 to move in the first direction, and at the same time, the control system controls the valve seat drive mechanism 7 to work, driving the rotating valve seat 6 to move in the first direction and following the movement of the moving seat 21. The valve seat drive mechanism 7 and the moving seat drive mechanism include a motor, a cylinder or an oil cylinder that provide power, and the control system is connected to the motor, the cylinder or the oil cylinder by wire or wirelessly to control them.

[0047] In one embodiment, the rotary valve seat 6 can be configured on the frame 1 in addition to being movably disposed, and can also be configured in other ways of movement, for example, the rotary valve seat 6 can be configured on the frame 1 in a swinging manner.

[0048] In one embodiment, in addition to being arranged on the rotary valve seat 6, the second rotary valve 33 can also be arranged on the moving seat 21. The second rotary valve 33 can be relatively fixed with the first rotary valve 32 and never have relative movement, or it can have relative movement with the first rotary valve 32. For example, the first rotary valve 32 is installed on the chip seat 22, and the second rotary valve 33 is installed on the moving seat 21. When the chip seat 22 moves relative to the moving seat 21, the first rotary valve 32 and the sequencing chip 4 do not move relative to each other, but the first rotary valve 32 moves relative to the second rotary valve 33.

[0049] In one embodiment, the second rotary valve 33 can be fixed to the rotary valve seat 6 by screws, or by clamping the rotary valve seat 6, or by magnetism, welding or bonding. The first rotary valve 32 can be fixed to the moving seat 21 by screws, or by clamping the moving seat 21, or by magnetism, welding or bonding.

[0050] The number of the first rotary valves 32 and the number of the second rotary valves 33 can be increased or decreased according to actual needs. The number of the first rotary valves 32 can be one or more than two, and the number of the second rotary valves 33 can also be one or more than two. When the number of the first rotary valves 32 is two or more, at least one first rotary valve 32 can be installed on the moving seat 21, and at least one first rotary valve 32 can be installed on the chip seat 22. When the number of the second rotary valves 33 is two or more, at least one second rotary valve 33 can be on the moving seat 21 or on the chip seat 22. In one embodiment, the liquid circuit system 3 can also have only the first rotary valve 32, without the second rotary valve 33.

[0051] Please refer to Figure 1 and Figure 2 , the number of the first rotary valve 32 and the number of the second rotary valve 33 are both two, there are two sequencing chip installation stations 221 on the chip holder 22, the two first rotary valves 32 correspond to the two sequencing chip installation stations 221 one by one, and one first rotary valve 32 supplies liquid to the sequencing chip 4 of one sequencing chip installation station 221. The two first rotary valves 32 correspond to the two second rotary valves 33 one by one, and the second rotary valve 33 can supply liquid to the corresponding first rotary valve 32.

[0052] In one embodiment, please refer to Figures 1 to 5 , the moving seat 21 and the rotary valve seat 6 are both configured on the frame 1 to move along the first direction, and the chip seat 22 is configured on the moving seat 21 to move along the second direction. The control system controls the rotary valve seat 6 to follow the moving seat 21 in the first direction. In one embodiment, the first rotary valve 32 is installed on the moving seat 21 or the chip seat 22, and the second rotary valve 33 is installed on the rotary valve seat 6. The sequencing flow channel 41 on the sequencing chip 4 extends along the first direction. In the process of photographing the sequencing flow channel 41, the sequencing chip 4 needs to move in the first direction, and the sequencing chip 4 also needs to move in the second direction. During the sequencing process of the sequencing chip 4, the moving distance of the moving seat 21 in the first direction is greater than the moving distance of the chip seat 22 in the second direction. The rotary valve seat 6 can only reciprocate along the first direction, which can simplify the structure of the rotary seat movement, and preferentially make the rotary seat follow the chip seat 22 in the first direction. Of course, in one embodiment, when the first rotary valve 32 is installed on the chip seat 22, the rotary valve seat 6 can move relative to the frame 1 in the second direction in addition to being able to move relative to the frame 1 in the first direction.

[0053] In one embodiment, please refer to Figure 1 , the first direction is perpendicular to the second direction. In addition to being perpendicular to the second direction, the angle between the first direction and the second direction may also be any value greater than 0 degrees and less than 90 degrees.

[0054] In one embodiment, please refer to Figure 1 and Figure 4 The rotary valve seat 6 is located on the upper side of the first rotary valve 32, making the overall space more compact and reducing the volume, and the two do not interfere with each other when they move relative to each other. In one embodiment, the two first rotary valves 32 are arranged side by side in the second direction, and the two second rotary valves 33 are arranged side by side in the second direction. The first rotary valve 32 and the second rotary valve 33 are both in the shape of a long strip extending along the first direction.

[0055] In one embodiment, in order to shorten the length of the pipeline, please refer to Figure 4The liquid path interface 321 of the first rotary valve 32 is located at one end of the first rotary valve 32 that is close to the sequencing chip 4, so that the distance between the liquid path interface 321 of the first rotary valve 32 and the sequencing chip 4 is shorter, thereby reducing the length of the chip liquid supply pipeline 31.

[0056] Similarly, the liquid circuit interface 331 (not fully shown in the figure) of the second rotary valve 33 is located at one end of the second rotary valve 33 that is close to the liquid circuit interface 321 of the first rotary valve 32, so that the liquid circuit interface 331 of the second rotary valve 33 is closer to the liquid circuit interface 321 (not fully shown in the figure) of the first rotary valve 32.

[0057] In one embodiment, please refer to Figures 1 to 3 The valve seat driving mechanism 7 is a pulley driving mechanism, which includes a driving wheel 71, a driven wheel 72 and a transmission belt 73. The driving wheel 71 and the driven wheel 72 are arranged at intervals along the first direction, and the transmission belt 73 is wound around the driving wheel 71 and the driven wheel 72. The rotary valve seat 6 is connected to the transmission belt 73, so that the driving wheel 71 can drive the rotary valve seat 6 to move through the transmission belt 73. The pulley driving mechanism also includes a driving motor 74, which is fixed on the frame 1, the driving wheel 71 is fixed on the output shaft of the driving motor 74, and the driven wheel 72 is rotatably configured on the frame 1.

[0058] To facilitate the installation of the valve seat drive mechanism 7, please refer to Figure 1 and Figure 2 The frame 1 includes a column 11 and a longitudinal beam 12 fixed on the column 11, the longitudinal beam 12 extends along a first direction, and the rotary valve seat 6 is movably arranged on the portion of the longitudinal beam 12 that overhangs one side of the column 11. By hanging the rotary valve seat 6 on one side of the column 11, the column 11 can be arranged at a position far away from the chip seat 22, which is convenient for the installation of the rotary valve seat 6 and also makes the overall spatial layout more compact. In the first direction, the drive motor 74 is on one side of the column 11, and the second rotary valve 33 is always on the other side of the column 11, so that the two sides of the column 11 can be balanced.

[0059] Please refer to Figure 1 , a guide rail 8 is fixed on the longitudinal beam 12, and the guide rail 8 extends in the first direction. The rotary valve seat 6 cooperates with the guide rail 8 in the first direction so that the guide rail 8 guides the rotary valve seat 6 to move. There are two columns 11 and longitudinal beams 12, and correspondingly, each longitudinal beam 12 is provided with a guide rail 8. After the rotary valve seat 6 is installed on the longitudinal beam 12, a gantry structure is formed. The side panels of the frame 1 are on the outside of the two columns 11. The rotary valve seat 6 includes a cross beam 61 extending in the second direction and a fixing frame 62 fixed to one side of the cross beam 61, and the first rotary valve 32 is fixed on the fixing frame 62. In one embodiment, please refer to Figure 1 , the second rotary valve 33 is fixed on the fixing frame 62 .

[0060] In one embodiment, in addition to the pulley drive mechanism, the valve seat drive mechanism 7 may also adopt a gear rack drive mechanism, a screw nut drive mechanism, a linear motor, a drive cylinder, etc.

[0061] In one embodiment, please refer to Figure 6 The liquid path system 3 also includes a liquid inlet block 35 located upstream of the sequencing chip 4 , a liquid outlet block 36 located downstream of the sequencing chip 4 , a syringe pump 37 , a confluence block 38 and a waste liquid bucket 39 .

[0062] In an embodiment of a sequencing chip processing device of the present application, please refer to Figures 1 to 6 The sequencing chip processing device includes a frame 1, a chip motion platform 2, and a first rotary valve 32 configured on a motion seat 21. The chip motion platform 2 includes a motion seat 21 and a motion seat driving mechanism. The motion seat 21 is used to drive the sequencing chip 4 to move. The motion seat 21 is movably configured on the frame 1, and the motion seat driving mechanism is used to drive the motion seat 21 to move. The first rotary valve 32 is used to select a target sample and / or a target reagent to be injected into a sequencing flow channel 41 of the sequencing chip 4. The sequencing chip processing device also includes a chip liquid supply pipeline 31 for connecting the first rotary valve 32 and the sequencing chip 4. The structures of the frame 1, the first rotary valve 32, and the chip motion platform 2 are the same as those described in any of the above embodiments, and will not be described in detail.

[0063] Further, in one embodiment, the sequencing chip processing device includes a second rotary valve 33; part of the liquid inlet of the first rotary valve 32 is connected to the second rotary valve 33, so that the second rotary valve 33 supplies liquid to the first rotary valve 32, the sequencing chip processing device includes a rotary valve seat 6 movably arranged on the frame 1 and a valve seat driving mechanism 7 for driving the rotary valve seat 6 to move, the second rotary valve 33 is arranged on the rotary valve seat 6, and the sequencing chip processing device includes a control system, the control system is connected to the motion seat driving mechanism, and is connected to the valve seat driving mechanism 7, so as to control the rotary valve seat 6 to follow the motion seat 21. The structures of the frame 1, the first rotary valve 32, the second rotary valve 33, the rotary valve seat 6, the chip motion platform 2, the control system and the valve seat driving mechanism 7 are the same as those described in any of the above embodiments, and will not be described in detail.

[0064] The above specific examples are used to illustrate the present invention, which are only used to help understand the present invention and are not intended to limit the present invention. For those skilled in the art of the present invention, some simple deductions, deformations or substitutions can be made based on the idea of ​​the present invention.

Claims

1. A gene sequencer, characterized in that: include: frame; A chip motion platform, comprising a motion seat and a motion seat driving mechanism for driving the motion seat; The motion seat is movably disposed on the rack to drive the sequencing chip to move; A liquid circuit system, the liquid circuit system is connected to the sequencing flow channel of the sequencing chip; the liquid circuit system includes a first rotary valve disposed on the motion seat, the first rotary valve is used to select a target sample and / or a target reagent to be injected into the sequencing flow channel; the liquid circuit system also includes a chip liquid supply pipeline connected between the first rotary valve and the sequencing chip; and an optical system for photographing and imaging the sequencing flow channel.

2. The gene sequencer according to claim 1, characterized in that: The liquid circuit system includes a second rotary valve; at least part of the liquid inlet of the first rotary valve is connected to the second rotary valve, so that the second rotary valve supplies liquid to the first rotary valve; the sequencer includes a rotary valve seat movably configured on the frame, and the second rotary valve is configured on the rotary valve seat; the sequencer includes a valve seat driving mechanism for driving the rotary valve seat to move; the gene sequencer includes a control system, and the control system is connected to the motion seat driving mechanism and to the valve seat driving mechanism, so as to control the rotary valve seat to follow the motion seat.

3. The gene sequencer according to claim 2, characterized in that: The moving seat is configured on the frame for movement along a first direction, the rotating valve seat is configured on the frame for movement along the first direction, and the control system controls the rotating valve seat to move along with the moving seat in the first direction.

4. The gene sequencer according to claim 3, characterized in that: The gene sequencer comprises a chip seat, which is movable along the second direction and configured on the moving seat, and the chip seat is used to install the sequencing chip, the angle between the first direction and the second direction is greater than 0 degree and not greater than 90 degrees, and the first direction is consistent with the extension direction of the sequencing flow channel; During the sequencing process of the sequencing chip, the moving distance of the moving seat in the first direction is greater than the moving distance of the chip seat in the second direction, and the rotary valve seat can only reciprocate along the first direction.

5. The gene sequencer according to any one of claims 2 to 4, characterized in that: The rotary valve seat is located at an upper side of the first rotary valve.

6. The gene sequencer according to any one of claims 2 to 4, characterized in that: The valve seat driving mechanism includes a driving wheel, a driven wheel and a transmission belt. The driving wheel and the driven wheel are arranged at intervals along a first direction. The transmission belt is wound around the driving wheel and the driven wheel. The rotating valve seat is connected to the transmission belt so that the driving wheel can drive the rotating valve seat to move through the transmission belt.

7. The gene sequencer according to claim 3 or 4, characterized in that: The frame includes a column and a longitudinal beam fixed on the column, the longitudinal beam extends along the first direction, the rotary valve seat is movably configured on the longitudinal beam, and the valve seat driving mechanism includes a driving motor; in the first direction, the driving motor is located on one side of the column, and the second rotary valve is always located on the other side of the column.

8. The gene sequencer according to claim 1 or 2, characterized in that: The moving seat is movably arranged on the frame along a first direction, the gene sequencer includes a chip seat, and the chip seat is movably arranged on the moving seat along a second direction. The chip seat is used to install the sequencing chip, and the angle between the first direction and the second direction is greater than 0 degree and not greater than 90 degrees. At least one of the first rotary valves is installed on the moving seat and / or at least one of the first rotary valves is installed on the chip seat.

9. A sequencing chip processing device, characterized in that: include: frame; The chip motion platform comprises a motion seat and a motion seat driving mechanism, wherein the motion seat is used to drive the sequencing chip to move, the motion seat is movably arranged on the frame, and the motion seat driving mechanism is used to drive the motion seat to move; and a first rotary valve, wherein the first rotary valve is used to select a target sample and / or a target reagent and inject it into a sequencing channel of a sequencing chip; the sequencing chip processing device also includes a chip liquid supply pipeline connected between the first rotary valve and the sequencing chip; the first rotary valve is arranged on the moving seat.

10. The sequencing chip processing device according to claim 9, characterized in that: The sequencing chip processing device includes a second rotary valve; part of the liquid inlet of the first rotary valve is connected to the second rotary valve so that the second rotary valve supplies liquid to the first rotary valve; the sequencing chip processing device includes a rotary valve seat movably configured on the frame, and the second rotary valve is configured on the rotary valve seat; the sequencing chip processing device includes a valve seat driving mechanism for driving the rotary valve seat to move; the sequencing chip processing device includes a control system, which is connected to the moving seat driving mechanism and to the valve seat driving mechanism to control the rotary valve seat to follow the moving seat to move.

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