A non-invasive blood pressure measuring device for experimental mice
By designing a non-invasive blood pressure measurement device for experimental mice that includes a mouse stabilization component, a measuring sleeve, a measuring instrument and a calibration component, the problems of poor stability and complex operation of experimental mice in the prior art are solved, and efficient and accurate blood pressure measurement and leakage testing are achieved.
Patent Information
- Application Number
- CN202421321157.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-12
- Publication Date
- 2025-04-08
- Estimated Expiration
- 2034-06-12
AI Technical Summary
The existing experimental mouse blood pressure measurement device is difficult to stabilize the experimental mouse during the measurement process, which makes it difficult to collect pulse signals, and is cumbersome to operate, prone to errors, and lacks continuous leakage testing.
A non-invasive blood pressure measurement device for experimental mice including a mouse stabilization assembly, a measuring sleeve, a measuring instrument and a calibration assembly is designed. The functions of stabilizing experimental mice and leak testing are realized through the removable connection and the use of a quick plug three-way valve.
Non-invasive, stable and high-precision measurement of blood pressure of experimental mice was achieved, the operation process was simplified, errors were reduced, and the integrity of the measurement tool was ensured through continuous leakage testing.
Smart Images
Figure CN222723002U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of medical equipment, in particular to a non-invasive blood pressure measuring device for experimental mice. Background Art
[0002] The rat tail pulse non-invasive blood pressure measurement system adopts the internationally popular tail cuff method for non-invasive blood pressure measurement. It is used to observe animal arterial blood pressure in chronic experiments. The measuring device consists of an experimental tray, a rat tail pulse blocker, a rat tail pulse sensor, and a mouse stabilizing assembly. Since experimental mice are active and flexible and difficult to control, it is difficult to collect effective pulse signals during the experiment.
[0003] Current devices for measuring the blood pressure of experimental mice often use a method of anesthetizing the experimental mice or capturing and squeezing the experimental mice to stabilize them. However, both anesthesia and capturing and squeezing destroy the normal existence of the experimental mice, which can easily affect the blood pressure test results and cause the measurement results to deviate from the actual results. At the same time, due to the difference in size between large and small mice, the measuring device needs to be replaced and calibrated repeatedly when the test object is changed, and the measured part of the experimental mouse's tail needs to be marked for each measurement. The operation is very cumbersome and complicated, and is prone to errors. In addition, since the mouse tail pulse signal is relatively weak, the accuracy of the measuring tool is very high. The measuring instrument needs to be calibrated before each measurement. The currently used measuring device needs to repeatedly disassemble and install the pressure gauge for calibration. Moreover, the existing measuring device lacks continuous leakage testing, and pressure leakage during operation cannot be corrected in time. Utility Model Content
[0004] The purpose of the utility model is to solve the shortcomings in the prior art.
[0005] In order to achieve the above purpose, the utility model adopts the following technical solutions:
[0006] A non-invasive blood pressure measuring device for experimental mice, comprising:
[0007] A mouse stabilizing component, which is used to stabilize experimental mice;
[0008] A measuring sleeve, which is used to be placed on the tail of the experimental mouse to collect pulse information;
[0009] A measuring instrument, the measuring instrument is used to receive the pulse information collected by the measuring set and process it into blood pressure information;
[0010] A calibration component, the calibration component is used to complete the calibration of the measuring instrument and the measuring sleeve;
[0011] The mouse stabilizing component and the measuring sleeve are detachably connected, and the measuring sleeve, the measuring instrument and the calibration component are connected via a first quick-insert three-way valve and a gas pipeline.
[0012] As a preferred technical solution, the mouse stabilizing component includes a telescopic box, which has an inner layer and an outer layer that can slide back and forth. When the inner layer is pulled out of the outer layer, the space inside the telescopic box becomes larger, and when the inner layer is extended into the outer layer, the space inside the telescopic box becomes smaller.
[0013] As a preferred technical solution, a limiting bolt is provided on the outer layer of the telescopic box, and when the limiting bolt is unscrewed, the inner and outer layers of the telescopic box have the freedom to stretch forward and backward; when the limiting bolt is screwed in, the relative positions of the inner and outer layers of the telescopic box are locked; or an elastic structure is provided between the inner and outer layers of the telescopic box, and the elastic structure has a tendency to pull the inner layer of the telescopic box into the outer layer.
[0014] As a preferred technical solution, a release door is provided at the head position of the telescopic box, and the release door has two configurations: open and closed; a switch lock is provided between the head position of the telescopic box and the release door, and the switch lock is used to control the opening and closing of the release door; and a vent is provided on the release door.
[0015] As a preferred technical solution, a rat tail door is provided at the tail position of the telescopic box, the rat tail door is inserted into the tail position of the telescopic box from the top to the bottom, and a tail hole is provided at the bottom position of the rat tail door.
[0016] As a preferred technical solution, the bottom of the telescopic box is provided with two parallel strip-shaped openings, and the strip-shaped openings are respectively arranged in the inner layer and the outer layer of the telescopic box, and the positions of the strip-shaped openings respectively arranged in the inner layer and the outer layer match.
[0017] As a preferred technical solution, the mouse stabilizing component also includes a mouse tail fixing plate, which is arranged at the bottom of the telescopic box. The mouse tail fixing plate and the telescopic box are movably arranged. The mouse stabilizing component has a first configuration and a second configuration. When in the first configuration, the mouse tail fixing plate slides to the bottom of the telescopic box to cover the strip opening; when in the second configuration, the mouse tail fixing plate slides out of the bottom range of the telescopic box, and the head position of the mouse tail fixing plate is connected to the tail position of the telescopic box.
[0018] As a preferred technical solution, the mouse tail fixing plate is provided with a mouse tail groove and a measuring groove, the mouse tail groove is used to accommodate the tail of the experimental mouse, and the measuring groove is used to accommodate the measuring sleeve, the measuring groove is opened on the basis of the mouse tail groove, the depth of the measuring groove is matched with the setting of the measuring sleeve, and the axial length of the measuring groove is greater than the axial length of the measuring sleeve; the mouse tail groove is provided with a scale.
[0019] As a preferred technical solution, the number of the measuring sleeves is two, the two measuring sleeves are connected through a second quick-insert three-way valve and a gas pipeline, and the second quick-insert three-way valve is connected to the first quick-insert three-way valve through a gas pipeline.
[0020] As a preferred technical solution, the calibration component includes a pressure gauge and a grip ball, the pressure gauge and the grip ball are connected through a third quick-insert three-way valve and a gas pipeline, and the third quick-insert three-way valve is connected to the first quick-insert three-way valve through a gas pipeline.
[0021] Beneficial effects: easy to use, by setting the sliding cooperation of the mouse tail fixing plate and the telescopic box, the limbs of the experimental mouse are lifted up, the fulcrum is lost, and the mouse cannot move around, thus avoiding the blood pressure fluctuation caused by the movement of the experimental mouse to the greatest extent, eliminating unexpected interference, and no need to use anesthesia, no need to harm the experimental mouse, adapting to experimental mice of various sizes, avoiding frequent replacement of equipment, and the calibration process is also very simple, and multiple measuring sleeves can be calibrated at one time; at the same time, a scale is set on the mouse tail groove, and the measuring sleeve is allowed to slide in the extension direction of the mouse tail, so as to ensure that each measurement is in the most suitable position of the mouse tail, greatly reducing the workload of continuous measurement of multiple experimental mice; in addition, by using a quick-insert three-way valve, the measuring sleeve can be leak tested without disassembling the gas pipeline to ensure that it is intact and avoid pressure leakage during work, resulting in inaccurate measurement. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] 1-mouse stabilizing assembly, 11-telescopic box, 1101-limiting bolt, 1102-elastic structure, 1103-release door, 1104-mouse tail door, 1105-strip opening, 12-mouse tail fixing plate, 1201-mouse tail groove, 1202-measuring groove, 2-measuring sleeve, 3-measuring instrument, 4-calibration assembly, 41-pressure gauge, 42-grip ball, 51-first quick-insert three-way valve, 52-second quick-insert three-way valve, 53-third quick-insert three-way valve.
[0023] Figure 1 is a schematic structural diagram of a mouse stabilizing component of a non-invasive blood pressure measurement device for experimental mice provided in an embodiment;
[0024] Figure 2 is a schematic structural diagram of a mouse stabilizing component of a non-invasive blood pressure measurement device for experimental mice provided in an embodiment;
[0025] Figure 3 1 is a schematic diagram of the bottom structure of a mouse stabilizing component of a non-invasive blood pressure measuring device for experimental mice provided in an embodiment;
[0026] Figure 4 1 is a schematic diagram of the bottom structure of a mouse stabilizing component of a non-invasive blood pressure measuring device for experimental mice provided in an embodiment;
[0027] Figure 5 1 is a schematic diagram of the principle of a non-invasive blood pressure measurement device for experimental mice provided in an embodiment;
[0028] Figure 6 It is a schematic diagram of the top structure of a mouse stabilizing component of a non-invasive blood pressure measurement device for experimental mice provided in an embodiment; DETAILED DESCRIPTION
[0029] It is worth noting that in order for this scheme to make a clear and unambiguous expression of the meaning, in the description of the mouse stabilizing component, "head" refers to the direction of the head of the experimental mouse designed in this scheme, "tail" refers to the direction of the tail of the experimental mouse designed in this scheme, "top" refers to the direction of the upper part of the experimental mouse designed in this scheme, and "bottom" refers to the direction of the lower part of the experimental mouse designed in this scheme. Please be aware of this.
[0030] A non-invasive blood pressure measuring device for experimental mice, comprising:
[0031] A mouse stabilizing component, which is used to stabilize experimental mice;
[0032] A measuring sleeve, which is used to be placed on the tail of the experimental mouse to collect pulse information;
[0033] A measuring instrument, the measuring instrument is used to receive the pulse information collected by the measuring set and process it into blood pressure information;
[0034] A calibration component, the calibration component is used to complete the calibration of the measuring instrument and the measuring sleeve;
[0035] The mouse stabilizing component and the measuring sleeve are detachably connected, and the measuring sleeve, the measuring instrument and the calibration component are connected via a first quick-insert three-way valve and a gas pipeline.
[0036] The quick-insert three-way valve used in this solution is a standard part commonly used in the medical device field. Its main structure includes three interfaces and a control handle. By rotating the control handle, the interconnection between any two interfaces or all three interfaces can be achieved. In this solution, there is no restriction on the brand selection of the quick-insert three-way valve.
[0037] As a preferred embodiment, the mouse stabilizing component includes a telescopic box having an inner layer and an outer layer that can slide back and forth. When the inner layer is pulled out of the outer layer, the space inside the telescopic box becomes larger, and when the inner layer is extended into the outer layer, the space inside the telescopic box becomes smaller.
[0038] Preferably, a bracket is provided at the bottom of the telescopic box, and when the telescopic box is placed on a plane, the bracket enables the telescopic box to be vacated.
[0039] By setting the traditional mouse cage structure into a retractable telescopic box, the problem that the same equipment cannot fix rats and mice in the same way is solved. It is adaptable to all sizes of experimental mice and can stabilize experimental mice of various sizes with the most appropriate tightness to ensure that the experimental mice cannot move around. At the same time, the experimental mice will not panic due to excessive squeezing, causing unreasonable fluctuations in blood pressure, which in turn affects the experimental results.
[0040] As a preferred embodiment, a limiting bolt is provided on the outer layer of the telescopic box. When the limiting bolt is unscrewed, the inner and outer layers of the telescopic box have the freedom to stretch forward and backward; when the limiting bolt is screwed in, the relative positions of the inner and outer layers of the telescopic box are locked; the limiting bolt scheme can be flexibly adjusted according to the size of the experimental mouse.
[0041] Or an elastic structure is provided between the inner layer and the outer layer of the telescopic box, and the elastic structure has a tendency to pull the inner layer of the telescopic box into the outer layer; the elastic structure solution enables the telescopic box to have a softer stabilizing force, which can adapt to different body shapes of experimental mice while avoiding panic of the experimental mice to the greatest extent.
[0042] Preferably, the elastic structure is configured as a plurality of springs evenly arranged on the outer surface of the inner layer of the telescopic box.
[0043] As a preferred embodiment, a release door is provided at the head position of the telescopic box, and the release door has two configurations: open and closed; a switch lock is provided between the head position of the telescopic box and the release door, and the switch lock is used to control the opening and closing of the release door; and a vent is provided on the release door.
[0044] The release door is used to release the experimental mice after the experiment is completed.
[0045] As a preferred embodiment, a rat tail door is provided at the tail position of the telescopic box, the rat tail door is inserted into the tail position of the telescopic box from the top to the bottom, and a tail hole is provided at the bottom position of the rat tail door.
[0046] As a preferred embodiment, the bottom of the telescopic box is provided with two parallel strip-shaped openings, and the strip-shaped openings are respectively arranged in the inner layer and the outer layer of the telescopic box, and the positions of the strip-shaped openings respectively arranged in the inner layer and the outer layer match.
[0047] The strip openings are used to make the limbs of the experimental mouse entering the telescopic box float in the air, lose the support points, and prevent the experimental mouse from moving.
[0048] As a preferred embodiment, the mouse stabilizing component also includes a mouse tail fixing plate, which is arranged at the bottom of the telescopic box. The mouse tail fixing plate and the telescopic box are movably arranged. The mouse stabilizing component has a first configuration and a second configuration. When in the first configuration, the mouse tail fixing plate slides to the bottom of the telescopic box to cover the strip opening; when in the second configuration, the mouse tail fixing plate slides out of the bottom range of the telescopic box, and the head position of the mouse tail fixing plate is connected to the tail position of the telescopic box.
[0049] As a preferred embodiment, the mouse tail fixing plate is provided with a mouse tail groove and a measuring groove, the mouse tail groove is used to accommodate the tail of the experimental mouse, and the measuring groove is used to accommodate the measuring sleeve, the measuring groove is opened on the basis of the mouse tail groove, the depth of the measuring groove is matched with the setting of the measuring sleeve, and the axial length of the measuring groove is greater than the axial length of the measuring sleeve, so that the front and rear position of the measuring sleeve can be adjusted according to the body size of the experimental mouse, so as to ensure that the measuring sleeve is in the best position on the tail of the experimental mouse according to the body size of the experimental mouse.
[0050] Preferably, a scale is provided on the rat tail groove. More preferably, among the scales on the rat tail groove, the 0 scale is provided at the connection between the rat tail fixing plate and the telescopic box in the second configuration, so as to facilitate the measurement of the tail length of the experimental mouse, thereby locating the measuring sleeve at the most suitable position of the tail.
[0051] Working principle: see Figure 4 When the mouse stabilizing component is in the first configuration, the mouse tail fixing plate slides to the bottom of the telescopic box. At this time, the mouse tail fixing plate covers the strip-shaped opening, and the telescopic box is a stable space. After placing the experimental mouse in the telescopic box and closing the mouse tail door, the tail of the experimental mouse extends out of the mouse tail hole. At this time, the mouse stabilizing component is changed to the second configuration, the mouse tail fixing plate slides out of the bottom range of the telescopic box, and the strip-shaped opening is opened, so that the limbs of the experimental mouse entering the telescopic box are vacated and lose the fulcrum, thereby preventing the movement of the experimental mouse. At the same time, the mouse tail groove in the mouse tail fixing plate just accommodates the mouse tail. Figure 6 The measuring groove is used to accommodate the measuring sleeve, so as to complete the measurement of the blood pressure of the experimental mouse. After the measurement is completed, the measuring sleeve is unlocked, the switch lock is opened, the release door is opened, and the experimental mouse is released.
[0052] As a preferred embodiment, the number of the measuring sleeves is two, the two measuring sleeves are connected via a second quick-insert three-way valve and a gas pipeline, and the second quick-insert three-way valve is connected to the first quick-insert three-way valve via a gas pipeline.
[0053] As a preferred embodiment, the calibration component includes a pressure gauge and a grip ball, the pressure gauge and the grip ball are connected through a third quick-insert three-way valve and a gas pipeline, and the third quick-insert three-way valve is connected to the first quick-insert three-way valve through a gas pipeline.
Claims
1. A non-invasive blood pressure measurement device for experimental mice, characterized in that: include A mouse stabilizing component (1), wherein the mouse stabilizing component (1) is used to stabilize experimental mice; A measuring sleeve (2), the measuring sleeve (2) being used for being placed on the tail of an experimental mouse to collect pulse information; A measuring instrument (3), the measuring instrument (3) is used to receive the pulse information collected by the measuring sleeve (2) and process it into blood pressure information; A calibration component (4), the calibration component being used to complete the calibration of the measuring instrument (3) and the measuring sleeve (2); The mouse stabilizing component (1) and the measuring sleeve (2) are detachably connected, and the measuring sleeve (2), the measuring instrument (3) and the calibration component (4) are connected via a first quick-insert three-way valve (51) and a gas pipeline.
2. The non-invasive blood pressure measuring device for experimental mice according to claim 1, characterized in that: The mouse stabilizing component (1) comprises a telescopic box (11), wherein the telescopic box (11) has an inner layer and an outer layer which can slide forward and backward. When the inner layer is pulled out of the outer layer, the space inside the telescopic box (11) becomes larger, and when the inner layer is extended into the outer layer, the space inside the telescopic box (11) becomes smaller.
3. The non-invasive blood pressure measuring device for experimental mice according to claim 2, characterized in that: The outer layer of the telescopic box (11) is provided with a limiting bolt (1101), and when the limiting bolt (1101) is unscrewed, the inner layer and the outer layer of the telescopic box (11) have the freedom to stretch forward and backward; when the limiting bolt (1101) is screwed in, the relative position of the inner layer and the outer layer of the telescopic box (11) is locked; or an elastic structure (1102) is provided between the inner layer and the outer layer of the telescopic box (11), and the elastic structure (1102) has the tendency to pull the inner layer of the telescopic box (11) into the outer layer.
4. The non-invasive blood pressure measuring device for experimental mice according to claim 2, characterized in that: A release door (1103) is arranged at the head position of the telescopic box (11), and the release door (1103) has two configurations: open and closed; a switch lock is arranged between the head position of the telescopic box (11) and the release door (1103), and the switch lock is used to control the opening and closing of the release door (1103); and a vent hole is arranged on the release door (1103).
5. The non-invasive blood pressure measuring device for experimental mice according to claim 2, characterized in that: A rat tail door (1104) is arranged at the tail position of the telescopic box (11), and the rat tail door (1104) is inserted into the tail position of the telescopic box (11) from the top to the bottom, and a tail hole is arranged at the bottom position of the rat tail door (1104).
6. The non-invasive blood pressure measuring device for experimental mice according to claim 2, characterized in that: The bottom of the telescopic box (11) is provided with two strip-shaped openings (1105) arranged in parallel, and the strip-shaped openings (1105) are respectively arranged in the inner layer and the outer layer of the telescopic box (11), and the positions of the strip-shaped openings (1105) respectively arranged in the inner layer and the outer layer are matched.
7. The non-invasive blood pressure measuring device for experimental mice according to claim 6, characterized in that: The mouse stabilizing component (1) further comprises a mouse tail fixing plate (12), wherein the mouse tail fixing plate (12) is arranged at the bottom of the telescopic box (11), and the mouse tail fixing plate (12) and the telescopic box (11) are movably arranged. The mouse stabilizing component (1) has a first configuration and a second configuration. When in the first configuration, the mouse tail fixing plate (12) slides to the bottom of the telescopic box (11) to cover the strip-shaped opening (1105); when in the second configuration, the mouse tail fixing plate (12) slides out of the bottom range of the telescopic box (11), and the head position of the mouse tail fixing plate (12) is connected to the tail position of the telescopic box (11).
8. The non-invasive blood pressure measuring device for experimental mice according to claim 7, characterized in that: The mouse tail fixing plate (12) is provided with a mouse tail groove (1201) and a measuring groove (1202); the mouse tail groove (1201) is used to accommodate the tail of the experimental mouse; the measuring groove (1202) is used to accommodate the measuring sleeve (2); the measuring groove (1202) is opened on the basis of the mouse tail groove (1201); the depth of the measuring groove (1202) is arranged to match the measuring sleeve (2); the axial length of the measuring groove (1202) is greater than the axial length of the measuring sleeve (2); and a scale is provided on the mouse tail groove (1201).
9. The non-invasive blood pressure measuring device for experimental mice according to claim 1, characterized in that: The number of the measuring sleeves (2) is two, and the two measuring sleeves (2) are connected via a second quick-insert three-way valve (52) and a gas pipeline, and the second quick-insert three-way valve (52) is connected to the first quick-insert three-way valve (51) via a gas pipeline.
10. The non-invasive blood pressure measuring device for experimental mice according to claim 1, characterized in that: The calibration component comprises a pressure gauge (41) and a grip ball (42); the pressure gauge (41) and the grip ball (42) are connected via a third quick-insert three-way valve (53) and a gas pipeline; the third quick-insert three-way valve (53) is connected to the first quick-insert three-way valve (51) via a gas pipeline.