A multi-modal fusion imaging system
By designing a multimodal fusion imaging system, combining visible light and X-ray imaging, and using rotating disc and X-ray shielding technology, the problems of detection object stability and radiation protection in micro CT technology are solved, achieving high-precision X-ray imaging and improving experimental safety.
Patent Information
- Application Number
- CN202421286665.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-06
- Publication Date
- 2025-04-08
- Estimated Expiration
- 2034-06-06
AI Technical Summary
When the existing microCT technology scans the detection object at 360° in all directions, it is difficult to ensure that the detection object is in a stable state, it is easy to introduce motion artifacts on the image, and generates motion mechanical interference on the detection object, affecting the detection accuracy. In addition, the open non-shielding structure of traditional CT equipment leads to low radiation protection costs and space utilization.
A multimodal fusion imaging system is designed, combining visible light imaging and X-ray imaging, and the accommodating chamber is moved back and forth in the first and second dark boxes through a driving device to realize the switching of the imaging mode. At the same time, the rotating disc and X-ray shielding cover and component are used to ensure that the object to be imaged remains stable during X-ray imaging, avoid motion artifacts, and effectively reduce radiation leakage.
It improves the detection accuracy of X-ray imaging, avoids the generation of motion artifacts, reduces radiation leakage, improves experimental safety, and simplifies the equipment structure and reduces cost and space requirements.
Smart Images
Figure CN222723038U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of optical imaging, and in particular relates to a multi-modal fusion imaging system. Background Art
[0002] As scientists continue to deepen their research on life sciences and their understanding of biological processes, the exploration of new treatments for human diseases has been accelerated, which has prompted the desire to explore targets, signal pathways, metabolic processes in animals and reconfirm biological process models in living animals. Animal live imaging has emerged and developed rapidly. Animal live imaging systems are widely used in life science, medical and pharmaceutical research fields such as embryonic development, gene function, transgenic models, immunology, oncology, and pharmacy. They are a very important platform for modern biology, medicine and pharmaceutical research.
[0003] Animal in vivo imaging technology refers to the application of imaging methods to conduct qualitative and quantitative research on biological processes at the tissue, cell and molecular levels in vivo. The principle is to optically label target genes, cells, drug molecules, etc. and inject them into animals, and then use sensitive optical elements (such as CCD) to convert the light signals in the animal into electrical signals, and then convert them into image output. Compared with traditional in vitro imaging or cell culture, this powerful combination of technology platforms provides researchers with fast and effective experimental tools, effectively speeding up the decision-making time of animal experiments, and is the latest research method for studying disease mechanisms and exploring new treatment approaches.
[0004] At present, in vivo optical imaging is mainly divided into bioluminescence imaging (BLI) and fluorescence imaging (FLUORENCE IMAGING, FL I). BLI is to connect the luciferase gene to the downstream of the promoter and stably integrate it into the cell chromosome, so that the luciferase is continuously expressed in the organism, and after the substrate is injected, it reacts with the expressed luciferase to emit light. FLI, on the other hand, uses fluorescent reporter genes (such as GFP, RFP) or fluorescent dyes such as Cyt and dyes for labeling, and the fluorescence generated by fluorescent proteins or dyes can form a fluorescent light source in the body.
[0005] In addition, there are many modes of in vivo optical imaging that can achieve multi-mode imaging, such as X-ray imaging, which is used for direct positioning imaging, thereby better distinguishing the internal structure of animals and greatly improving the accuracy of research. However, currently visible light imaging instruments and X-ray imaging instruments are set up separately, which makes it inconvenient for experimenters to switch imaging instruments.
[0006] In biomedicine, as a preclinical research method, a large number of experimental analysis work is completed on live small animals, ex vivo tissues or material analysis. Since ordinary CT cannot meet the stringent resolution requirements in the field of scientific research and material analysis, micro CT (i.e. X-ray imaging) has become a tool and means urgently needed by both academia and industry; Micro CT (micro computed tomography, micro-computer tomography technology), also known as micro CT, micro CT, is a non-destructive 3D imaging technology that can clearly understand the internal microscopic structure of the sample without destroying the sample. The biggest difference between it and ordinary clinical CT is that the resolution is extremely high, which can reach the micron (μm) level, and has a good "microscopic" effect.
[0007] In order to achieve a 360° all-round scan of the detection object, the micro-CT in the prior art usually adopts a method of fixing the frame and rotating the loading platform. This method has the problem of difficulty in ensuring that the detection object is in a stable state, easily introducing motion artifacts on the image, and causing mechanical interference to the detection object, thereby affecting the accuracy of micro-CT detection.
[0008] Secondly, many CT devices currently use an open non-shielded structure. In order to achieve the purpose of shielding X-rays, the main method is to install lead plates around the CT equipment for radiation protection, but no additional lead plates are added at the sample port for radiation protection. This structure requires a lead room, which has low cost and space utilization. Utility Model Content
[0009] The utility model aims to overcome the existing technical defects and provide a multi-modal fusion imaging system, which realizes the combination of visible light imaging and X-ray imaging and improves the detection accuracy during X-ray imaging.
[0010] In order to solve the above technical problems, the utility model provides a multi-modal fusion imaging system, comprising:
[0011] Support base;
[0012] A first dark box, which is arranged on the supporting base, wherein a storage bin for accommodating the object to be imaged is suspended at the lower end of the first dark box, the upper end of the storage bin is transparent, and a camera module for irradiating toward the storage bin is arranged at the upper end of the first dark box;
[0013] A second dark box is arranged on one side of the supporting base and the first dark box, a rotating disk arranged vertically is rotatably arranged in the second dark box, an inlet and outlet passage is coaxially arranged at the center of the rotating disk at a position corresponding to the accommodating bin, a first opening and a second opening are respectively arranged at adjacent sides of the first dark box and the second dark box at positions corresponding to the inlet and outlet passage, and a shielding door for closing the first opening and being able to be lifted up and down is also arranged in the first dark box; an X-ray instrument and a flat panel detector arranged opposite to each other and located on both sides of the inlet and outlet passage are slidably arranged on one side of the rotating disk;
[0014] A driving device is arranged on the supporting base and is used to drive the accommodating bin to move back and forth left and right in the first dark box and the second dark box, so that the accommodating bin can be moved between the X-ray apparatus and the flat panel detector.
[0015] Furthermore, a fixed frame is provided inside the second dark box, a fixed plate is provided on one side of the fixed frame close to the first dark box, the rotating disk is rotatably arranged on the inner side of the fixed plate and is located inside the fixed frame, an X-ray shielding cover is provided on the outer peripheral cover of the fixed frame, a third opening connected to the third opening is provided at the center of the fixed plate at a position corresponding to the entry and exit channel; a fifth motor is provided on the fixed plate, which is transmission-connected to the rotating disk and drives the rotating disk to rotate; an X-ray shielding component for closing the third opening is provided at one end of the accommodating chamber away from the second dark box.
[0016] Furthermore, the driving device includes a first sliding seat arranged on the supporting base and located on one side of the first dark box, a first lead screw rotatably arranged on the first sliding seat and extending left and right, a first guide rail arranged on the first sliding seat, a horizontal driving rod slidably arranged on the first guide rail and at the same height as the accommodating bin, and a first motor for driving the first lead screw to rotate, a first slider slidably arranged on the first guide rail, a first lead screw nut threadedly connected on the first lead screw, one end of the horizontal driving rod is fixedly connected to the first slider and the first lead screw nut through a connecting piece, and the other end is connected to one end of the accommodating bin after being inserted into the first dark box, so that after the horizontal driving rod slides left and right relative to the first guide rail, the accommodating bin is driven to move back and forth left and right in the first dark box and the second dark box.
[0017] Furthermore, the multimodal fusion imaging system also includes a decorative cover arranged on the outside of the driving device; a channel for the pipeline to pass through is provided in the axial middle of the horizontal driving rod, and an air nozzle is provided between the channel and the accommodating chamber to connect the two.
[0018] Furthermore, a longitudinal drive device for driving the shielding door to move up and down is also provided in the first dark box, and the longitudinal drive device includes a second sliding seat provided on the inner wall of the first dark box and arranged longitudinally, a second lead screw rotatably provided on the second sliding seat and extending longitudinally, a second guide rail provided on the second sliding seat, and a second motor for driving the second lead screw to rotate, a second slider is slidably provided on the second guide rail, the second lead screw passes through the second slider and is threadedly connected to the second slider, and the upper end or the lower end of the shielding door is fixedly connected to the second slider.
[0019] Furthermore, the multimodal fusion imaging system also includes a turntable rotatably provided on the X-ray instrument and a stepper motor for driving the turntable to rotate, the turntable is provided with N through holes in a circular array, N is a positive integer greater than 2, and X-ray filters of different thicknesses and / or different materials are respectively provided at the N-1 through holes, and the turntable is rotated so that different X-ray filters or through holes are located in front of the emission hole of the X-ray instrument.
[0020] Furthermore, the turntable is provided with four through holes in a circular array, and aluminum sheets and / or copper sheets of different thicknesses are arranged in three of the through holes.
[0021] Furthermore, no X-ray filter is provided in the first through hole, a high-purity aluminum sheet with a thickness of 0.5 mm is provided in the second through hole, a high-purity aluminum sheet with a thickness of 1 mm is provided in the third through hole, and a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.06 mm are stacked in the fourth through hole.
[0022] Furthermore, the multimodal fusion imaging system also includes a first driving platform for driving the X-ray instrument to move radially along the rotating disk, the first driving platform includes a third sliding seat arranged radially along the rotating disk, a third screw rotatably arranged on the third sliding seat and extending radially along the rotating disk, a third guide rail arranged on the third sliding seat, and a third motor for driving the third screw to rotate, a third slider is slidably provided on the third guide rail, a third screw nut is threadedly connected on the third screw, and the X-ray instrument is fixedly connected to the third slider and the third screw nut through a connecting plate; the rotating disk is also provided with a first travel switch located on one side of the third sliding seat and used to limit the forward and backward sliding travel of the X-ray instrument.
[0023] Furthermore, the multimodal fusion imaging system also includes a second driving platform for driving the flat-panel detector to move radially along the rotating disk, the second driving platform includes a fourth sliding seat arranged radially along the rotating disk, a fourth lead screw rotatably arranged on the fourth sliding seat and extending radially along the rotating disk, a fourth guide rail arranged on the fourth sliding seat, and a fourth motor for driving the fourth lead screw to rotate, a fourth slider is slidably provided on the fourth guide rail, a fourth lead screw nut is threadedly connected on the fourth lead screw, and the flat-panel detector is fixedly connected to the fourth slider and the fourth lead screw nut through an adapter plate; the rotating disk is also provided with a second travel switch located on one side of the fourth sliding seat and used to limit the forward and backward sliding travel of the flat-panel detector.
[0024] Furthermore, the camera module includes a camera arranged on the top of the first dark box and irradiating toward the accommodating chamber, and a light source module arranged around the camera; the accommodating chamber is a hollow columnar structure with an opening at its upper end, and a transparent cover that can be opened and closed is provided at the opening.
[0025] The utility model has the following beneficial effects:
[0026] In the utility model, a first dark box and a second dark box are provided at the same time, and a driving device is used to enable a storage bin for storing objects to be imaged to move back and forth in the first dark box and the second dark box, so that the objects to be imaged in the storage bin can realize visible light imaging and X-ray imaging in the first dark box and the second dark box respectively, that is, the combination of infrared imaging and visible light imaging is realized; and in X-ray imaging, the storage bin remains stationary, and the X-ray instrument and the flat-panel detector rotate around the storage bin driven by the rotating disk, and a plurality of CT images of the objects to be imaged are obtained in the process of rotation. Because the storage bin remains stationary, it is ensured that the objects to be imaged are in a stable state, and motion artifacts are avoided during X-ray imaging to affect the accuracy of micro-CT detection.
[0027] Secondly, the X-ray shielding cover and the X-ray shielding component are used together to shield the X-rays in the second dark box, which can effectively reduce the radiation leakage during the experiment, thereby reducing the harm to the operators and improving the safety of the experiment. Secondly, the X-ray shielding cover and the X-ray shielding component are built-in and fixed inside the chassis, which is convenient for carrying and transporting the whole machine, and the structure is simple and easy to install.
[0028] Additional aspects and advantages of the present invention will be partially given in the following description, which will become apparent from the following description or be understood through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] The drawings described herein are used to provide a further understanding of the present invention, constitute a part of the present application, and do not constitute an improper limitation of the present invention. In the drawings:
[0030] Figure 1 is a schematic diagram of a multimodal fusion imaging system in an embodiment;
[0031] Figure 2 is a cross-sectional view of a multi-modal fusion imaging system in an embodiment;
[0032] Figure 3 for Figure 2 A is an enlarged schematic diagram;
[0033] Figure 4 This is a schematic diagram of the support base, the driving device and the accommodating compartment after being assembled in the embodiment;
[0034] Figure 5 is a schematic diagram of the longitudinal drive device and the shielding door after being assembled in the embodiment;
[0035] Figure 6 This is a schematic diagram of the interior of the second dark box in the embodiment after the box body is removed;
[0036] Figure 7 for Figure 6 Schematic diagram of removing the shielding cover;
[0037] Figure 8 for Figure 7 Schematic diagram of removing the inner shielding cover;
[0038] Fig. 9 This is a schematic diagram of the first driving platform and the X-ray apparatus after being assembled in the embodiment;
[0039] Fig.10 for Fig. 9 Schematic diagram of another perspective;
[0040] Fig.11 is a schematic diagram of the first driving platform and the flat panel detector after being assembled in the embodiment;
[0041] Fig.12 for Fig.11 Schematic diagram from another perspective. DETAILED DESCRIPTION
[0042] In order to more fully understand the technical content of the present invention, the present invention will be further introduced and explained in conjunction with the accompanying drawings and specific embodiments below; it should be noted that descriptions such as "first" and "second" in the text are used to distinguish different components, etc., and do not represent the order of precedence, nor do they limit the "first" and "second" to different types.
[0043] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments; based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the utility model.
[0044] Example
[0045] like Figures 1 to 12 As shown, the multimodal fusion imaging system shown in this embodiment includes a supporting base 1, a first dark box 2, a second dark box 3, and a driving device 6. The first dark box 2 is arranged on the supporting base 1, and a storage bin 20 for accommodating an object to be imaged is suspended at the lower end of the first dark box 2. The upper end of the storage bin 20 is transparent, that is, after the object to be imaged (such as a mouse, etc.) is placed in the storage bin 20, the object to be imaged inside can be seen and photographed through the transparent part of the upper end, which is convenient for photographing and imaging the object to be imaged; the first dark box 2 is provided with a camera module for irradiating toward the accommodating chamber 20 at the upper end; the second dark box 3 is arranged on the right side of the supporting base 1 and the first dark box 2, and a rotating disk 30 arranged vertically is rotatably provided in the second dark box 3, and an inlet and outlet channel 31 is coaxially provided at the center of the rotating disk 30 at the position corresponding to the accommodating chamber 20, that is, the axial center of the accommodating chamber 20 and the center of the rotating disk 30 are located on the same axis, and the size of the inlet and outlet channel 31 is larger than the size of the accommodating chamber 20, so that the accommodating chamber 20 can pass through, and the adjacent first dark box 2 and the second dark box 3 are convenient for the storage of the storage bin 20. A first opening 21 and a second opening 32 are respectively provided at positions corresponding to the inlet and outlet passages 31. The sizes of the first opening 21 and the second opening 32 are also larger than the size of the storage bin 20. A shielding door 22 for closing the first opening 21 and being able to be lifted up and down is also provided in the first dark box 2. The first opening 21 can be opened or closed by operating the lifting and lowering of the shielding door 22. In the closed state, the shielding door 22 plays a role of shading, and in the open state, the storage bin 20 is convenient to pass through. An X-ray apparatus 4 and a flat-panel detector 5 are slidably provided on one side of the rotating disk 30. The X-ray apparatus 4 and the flat-panel detector 5 are arranged opposite to each other and located on both sides of the inlet and outlet passages 31. That is, the rays emitted by the X-ray apparatus 4 will be received by the opposite flat-panel detector 5. The driving device 6 is provided on the supporting base 1 and is used to drive the storage bin 20 to move back and forth in the first dark box 2 and the second dark box 3, so that the storage bin 20 can pass through the first opening 21, the second opening 32 and the inlet and outlet passage 32 to the right in turn and then move to between the X-ray apparatus 4 and the flat-panel detector 5, so as to realize X-ray imaging of the object to be imaged in the storage bin 20.
[0046] In one embodiment, if Figure 6-8As shown, a fixing frame 33 is provided inside the second dark box 3, and a fixing plate 34 is provided on one side of the fixing frame 33 close to the first dark box 2. The rotating disk 30 is rotatably arranged on the inner side of the fixing plate 34 and suspended in the fixing frame 33. An X-ray shielding cover 35 is provided on the outer peripheral cover of the fixing frame 33 to play a role of radiation shielding to prevent X-rays from leaking outward and generating radiation; a third opening 36 connected to the fixing plate 34 is provided at the center of the fixing plate 34 at a position corresponding to the inlet and outlet channel 31, and the size of the third opening 36 is the same as that of the inlet and outlet channel 31; an X-ray shielding member 23 for closing the third opening 36 is provided at one end of the accommodating chamber 20 away from the second dark box 2, that is, in the process of the accommodating chamber moving to the right, the shielding member 23 is driven to move to the right, and when the accommodating chamber moves to the position between the X-ray instrument 4 and the flat panel detector 5, the X-ray shielding member 23 just closes the third opening 36 to prevent X-rays from leaking outward from the inlet and outlet channel 31.
[0047] In one embodiment, a fifth motor 37 is provided on the fixed plate 34, which is transmission-connected to the rotating disk 30 and drives the rotating disk 30 to rotate; preferably, a gear-engaging transmission connection structure is preferably adopted between the fifth motor and the rotating disk, that is, a driving gear (not shown in the figure) is provided on the rotating shaft of the fifth motor, and a driven gear (not shown in the figure) meshing with the driving gear is provided on the rotating disk, which belongs to the conventional transmission connection structure in the existing art and will not be described in detail here.
[0048] In one embodiment, if Figure 4As shown, the driving device 6 includes a first sliding seat 61 provided on the supporting base 1 and located on the left side of the first dark box 2, a first lead screw 62 rotatably provided on the first sliding seat 61 and extending left and right, two first guide rails 63 provided on both sides of the first sliding seat 61, a horizontal driving rod 64 slidably provided on the first guide rail 63 and flush with the accommodating bin 20, and a first motor 65 for driving the first lead screw 62 to rotate, a first slider 66 is slidably provided on the first guide rail 63, a first lead screw nut 67 is threadedly connected on the first lead screw 62, one end of the horizontal driving rod 64 is fixedly connected to the first slider 66 and the first lead screw nut 67 through a vertically provided connecting piece 68, and the other end is connected to one end of the accommodating bin 20 after being inserted into the first dark box 2, and the first motor 65 is used to drive the first lead screw 62 to rotate. The first lead screw nut 67 is moved left and right along the first lead screw 62, thereby driving the horizontal driving rod 64 and the first sliding block 66 to move left and right, so that after the horizontal driving rod 64 slides left and right relative to the first guide rail 63, the accommodating chamber 20 is driven to move back and forth left and right in the first dark box 2 and the second dark box 3. When moving to the right, it can pass through the first opening 21, the second opening 32, the third opening 36 and the entrance and exit channel 32 in sequence to the right and then move to between the X-ray device 4 and the flat-panel detector 5. At this time, the shielding door 22 is opened. When moving to the left, the accommodating chamber 20 is retreated into the first dark box 2. At this time, the shielding door 22 is closed, and when the accommodating chamber 20 is retreated into the first dark box 2, the X-ray shielding member 23 can also be used to close the hole where the horizontal driving rod 64 is inserted into the first dark box 2 to achieve the effect of shading.
[0049] In one embodiment, if Figure 1 and Figure 2 As shown, the multimodal fusion imaging system also includes a decorative cover 60 arranged on the outside of the driving device to improve the appearance. A channel 69 for the pipeline to pass through is provided in the middle of the axial direction of the horizontal driving rod 64. One end of the accommodating chamber 20 is provided with a gas nozzle 24 connecting the inside of the accommodating chamber with the channel 69. One end of the gas nozzle is connected to an external gas supply device for supplying anesthetic gas through a pipeline passing through the channel 69 to supply anesthetic gas into the accommodating chamber 20, so that the object to be imaged in the accommodating chamber 20 is always in an anesthetized state under the anesthesia of the anesthetic gas.
[0050] In one embodiment, if Figure 5As shown, a longitudinal driving device 7 for driving the shielding door 22 to move up and down is also provided in the first dark box 2. The longitudinal driving device 7 includes a second sliding seat 71 provided on the inner wall of the first dark box 2 and arranged longitudinally, a second lead screw 72 rotatably provided on the second sliding seat 71 and extending longitudinally, a second guide rail 73 provided on the second sliding seat 71, and a second motor 74 for driving the second lead screw 72 to rotate. A second slider 75 is slidably provided on the second guide rail 73. The second lead screw 72 passes through the second slider 75 and is threadedly connected to the second slider 75. The upper end or the lower end of the shielding door 22 is fixedly connected to the second slider 75. That is, under the drive of the second motor 74, the second slider 75 will drive the shielding door 22 to move up and down.
[0051] In one embodiment, if Figure 9-10 As shown, the multimodal fusion imaging system also includes a turntable 40 rotatably arranged on the X-ray instrument 4 and a stepper motor 41 for driving the turntable 40 to rotate. The turntable 40 is provided with N through holes 44 in a circular array, N is a positive integer greater than 2, and N-1 through holes are respectively provided with X-ray filters 42 of different thicknesses and / or different materials. By rotating the turntable 40 so that different X-ray filters 42 or through holes are located in front of the emission hole of the X-ray instrument 4, the corresponding X-ray filter 42 on the turntable 40 is selected to filter the X-rays or the through holes are not used to filter the X-rays according to the imaging conditions required for different imaging objects.
[0052] Preferably, a driving gear 43 is provided on the rotating shaft of the stepping motor 41 , and gear teeth meshing with the driving gear 43 are provided on the outer periphery of the rotating disk 40 .
[0053] In one embodiment, four through holes 44 are provided on the turntable 40 in a circular array, and aluminum sheets and / or copper sheets of different thicknesses are provided in three of the through holes 44; preferably, no X-ray filter is provided in the first through hole, which maintains a through hole shape and is used for imaging low-voltage, low-contrast samples; a high-purity aluminum sheet with a thickness of 0.5 mm is provided in the second through hole, which is used for imaging low-contrast samples; a high-purity aluminum sheet with a thickness of 1 mm is provided in the third through hole, which is used for imaging soft tissue (fat analysis) samples; a high-purity aluminum sheet with a thickness of 0.5 mm and a copper sheet with a thickness of 0.06 mm are stacked up and down in the fourth through hole, which is used for standard scanning.
[0054] In one embodiment, if Figure 9-10As shown, the multimodal fusion imaging system also includes a first driving platform 8 for driving the X-ray instrument 4 to move radially along the rotating disk 30. The first driving platform 8 includes a third sliding seat 80 arranged radially along the rotating disk 30, a third lead screw 81 rotatably arranged on the third sliding seat 80 and extending radially along the rotating disk 30, two third guide rails 82 respectively arranged on both sides of the third sliding seat 80, and a third motor 83 for driving the third lead screw 71 to rotate. A third slider 84 is slidably arranged on the third guide rail 82, and a third lead screw nut 85 is threadedly connected on the third lead screw 81. The X-ray instrument 4 is fixedly connected to the third slider 84 and the third lead screw nut 85 through a connecting plate 86, so that the third motor 83 is used to drive the X-ray instrument 4 to move radially along the rotating disk 30; Fig. 9 In the figure, the third screw rod and the third motor can be connected by gear meshing, or by gear and belt matching (not shown in the figure).
[0055] In one embodiment, the rotating disk 30 is further provided with two first travel switches 87 located on one side of the third sliding seat 80 and used to limit the forward and backward sliding travel of the X-ray device 4, and the two first travel switches 87 are respectively located at both ends of the third sliding seat 80.
[0056] In one embodiment, if Figure 11-12 As shown, the multimodal fusion imaging system also includes a second driving platform 9 for driving the flat panel detector 5 to move radially along the rotating disk 30. The second driving platform 9 includes a fourth sliding seat 90 arranged radially along the rotating disk 30, a fourth lead screw 91 rotatably arranged on the fourth sliding seat 90 and extending radially along the rotating disk 30, a fourth guide rail 92 arranged on the fourth sliding seat 90, and a fourth motor 93 for driving the fourth lead screw 91 to rotate. A fourth slider 94 is slidably arranged on the fourth guide rail 92, and a fourth lead screw nut 95 is threadedly connected on the fourth lead screw 91. The flat panel detector 5 is fixedly connected to the fourth slider 94 and the fourth lead screw nut 95 through an adapter plate 96, so that the fourth motor 93 is used to drive the flat panel detector 5 to move radially along the rotating disk 30; Fig.12 In the figure, the fourth screw rod and the fourth motor can be connected by gear meshing, or by gear and belt matching (not shown in the figure).
[0057] In one embodiment, the rotating disk is further provided with two second travel switches 97 located at one side of the fourth sliding seat 90 and used to limit the forward and backward sliding travel of the flat panel detector 5 , and the two second travel switches 97 are respectively located at two ends of the fourth sliding seat 90 .
[0058] In one embodiment, if Figure 7 As shown, an inner shielding cover 38 is also provided on the rotating disk 30 and covers the outside of the flat panel detector. The inner shielding cover 38 is opened at one end facing the X-ray instrument.
[0059] In one embodiment, if Figure 2-3 As shown, the camera module includes a camera 25 disposed on the top of the first dark box 2 and irradiating toward the accommodating chamber 20, and a light source module 26 disposed around the camera 25, and the light source module 26 provides light when the camera is shooting; preferably, the camera is a visible light camera.
[0060] In one embodiment, if Figure 4 As shown, the storage bin 20 is a hollow columnar structure with an opening at the upper end thereof, and a transparent cover plate 27 that can be opened and closed is provided at the opening.
[0061] In one embodiment, if Figure 2 As shown, a pad 28 is further provided inside the accommodating bin 20 .
[0062] In one embodiment, support legs 10 and / or rollers 11 are provided at the bottom of the support base 1 and the second dark box 3 .
[0063] In other embodiments, the storage compartment is made of carbon fiber.
[0064] In other embodiments, the transparent cover is made of transparent organic glass.
[0065] In other embodiments, the backing plate is made of foam to reduce the imaging effect.
[0066] In other embodiments, the X-ray shielding member and the X-ray shielding cover are preferably made of lead sheets; of course, the X-ray shielding member and the X-ray shielding cover may also be made of other shielding materials that can shield X-rays.
[0067] In other embodiments, the fixing plate is preferably a 20 mm thick aluminum plate, and the thick aluminum plate is used to shield the X-rays.
[0068] In other embodiments, the fixing plate may also be made of lead plate.
[0069] In the above, the multimodal fusion imaging system is an animal imaging device that integrates three imaging modalities: X-ray CT imaging, bioluminescence imaging, and molecular fluorescence imaging. The advantages of CT imaging and optical imaging complement each other to achieve the effect of "1+1" being far greater than 2. Combined with the three-dimensional imaging algorithm, it can realize accurate positioning and diagnosis of tumors and other diseases in three-dimensional space.
[0070] The technical solutions provided by the embodiments of the present invention are introduced in detail above. Specific examples are used in this article to illustrate the principles and implementation methods of the embodiments of the present invention. The description of the above embodiments is only applicable to help understand the principles of the embodiments of the present invention. At the same time, for those skilled in the art, according to the embodiments of the present invention, there will be changes in the specific implementation methods and application scopes. In summary, the content of this specification should not be understood as a limitation on the present invention.
Claims
1. A multimodal fusion imaging system, characterized in that: include: Support base; A first dark box, which is arranged on the supporting base, wherein a storage bin for accommodating the object to be imaged is suspended at the lower end of the first dark box, the upper end of the storage bin is transparent, and a camera module for irradiating toward the storage bin is arranged at the upper end of the first dark box; A second dark box is arranged on one side of the supporting base and the first dark box, a rotating disk arranged vertically is rotatably arranged in the second dark box, an inlet and outlet passage is coaxially arranged at the center of the rotating disk at a position corresponding to the accommodating bin, a first opening and a second opening are respectively arranged at adjacent sides of the first dark box and the second dark box at positions corresponding to the inlet and outlet passage, and a shielding door for closing the first opening and being able to be lifted up and down is also arranged in the first dark box; an X-ray instrument and a flat panel detector arranged opposite to each other and located on both sides of the inlet and outlet passage are slidably arranged on one side of the rotating disk; A driving device is arranged on the supporting base and is used to drive the accommodating bin to move back and forth left and right in the first dark box and the second dark box, so that the accommodating bin can be moved between the X-ray apparatus and the flat panel detector.
2. The multimodal fusion imaging system according to claim 1, characterized in that: A fixed frame is provided inside the second dark box, a fixed plate is provided on one side of the fixed frame close to the first dark box, the rotating disk is rotatably arranged on the inner side of the fixed plate and is located inside the fixed frame, an X-ray shielding cover is provided on the outer peripheral cover of the fixed frame, a third opening connected to the entrance and exit channel is provided at the center of the fixed plate at a position corresponding to the entrance and exit channel; a fifth motor is provided on the fixed plate, which is transmission-connected to the rotating disk and drives the rotating disk to rotate; an X-ray shielding component for closing the third opening is provided at one end of the accommodating chamber away from the second dark box.
3. The multimodal fusion imaging system according to claim 1, characterized in that: The driving device includes a first sliding seat arranged on the supporting base and located on one side of the first dark box, a first lead screw rotatably arranged on the first sliding seat and extending left and right, a first guide rail arranged on the first sliding seat, a horizontal driving rod slidably arranged on the first guide rail and at the same height as the accommodating bin, and a first motor for driving the first lead screw to rotate, a first sliding block slidably provided on the first guide rail, a first lead screw nut threadedly connected on the first lead screw, one end of the horizontal driving rod is fixedly connected to the first sliding block and the first lead screw nut through a connecting piece, and the other end is connected to one end of the accommodating bin after being inserted into the first dark box, so that after the horizontal driving rod slides left and right relative to the first guide rail, the accommodating bin is driven to move back and forth left and right in the first dark box and the second dark box.
4. The multimodal fusion imaging system according to claim 3, characterized in that: It also includes a decorative cover arranged outside the driving device; a channel for the pipeline to pass through is provided in the axial middle of the horizontal driving rod, and an air nozzle connecting the channel and the accommodating chamber is provided between the two.
5. The multimodal fusion imaging system according to claim 1, characterized in that: The first dark box is also provided with a longitudinal driving device for driving the shielding door to move up and down, and the longitudinal driving device includes a second sliding seat provided on the inner wall of the first dark box and arranged longitudinally, a second lead screw rotatably provided on the second sliding seat and extending longitudinally, a second guide rail provided on the second sliding seat, and a second motor for driving the second lead screw to rotate, a second slider is slidably provided on the second guide rail, the second lead screw passes through the second slider and is threadedly connected to the second slider, and the upper end or the lower end of the shielding door is fixedly connected to the second slider.
6. The multimodal fusion imaging system according to any one of claims 1 to 5, characterized in that: It also includes a turntable that is rotatable on the X-ray instrument and a stepper motor for driving the turntable to rotate, the turntable is provided with N through holes in a circular array, N is a positive integer greater than 2, and X-ray filters of different thicknesses and / or different materials are respectively provided at the N-1 through holes, and the turntable is rotated so that different X-ray filters or through holes are located in front of the emission hole of the X-ray instrument.
7. The multimodal fusion imaging system according to claim 6, characterized in that: The turntable is provided with four through holes in a circular array, wherein aluminum sheets and / or copper sheets of different thicknesses are arranged in three of the through holes.
8. The multimodal fusion imaging system according to claim 7, characterized in that: The first through hole has no X-ray filter, the second through hole has a 0.5 mm thick high-purity aluminum sheet, the third through hole has a 1 mm thick high-purity aluminum sheet, and the fourth through hole has a 0.5 mm thick high-purity aluminum sheet and a 0.06 mm thick copper sheet stacked together.
9. The multimodal fusion imaging system according to any one of claims 1 to 5, characterized in that: It also includes a first driving platform for driving the X-ray instrument to move radially along the rotating disk and a second driving platform for driving the flat panel detector to move radially along the rotating disk, the first driving platform includes a third sliding seat arranged radially along the rotating disk, a third lead screw rotatably arranged on the third sliding seat and extending radially along the rotating disk, a third guide rail arranged on the third sliding seat, and a third motor for driving the third lead screw to rotate, a third slider is slidably arranged on the third guide rail, a third lead screw nut is threadedly connected on the third lead screw, and the X-ray instrument is fixedly connected to the third slider and the third lead screw nut through a connecting plate; the rotating disk is also provided with a first travel switch located on one side of the third sliding seat and used to limit the forward and backward sliding travel of the X-ray instrument; The second driving platform includes a fourth sliding seat arranged along the radial direction of the rotating disk, a fourth lead screw rotatably arranged on the fourth sliding seat and extending along the radial direction of the rotating disk, a fourth guide rail arranged on the fourth sliding seat, and a fourth motor for driving the fourth lead screw to rotate, a fourth slider is slidably arranged on the fourth guide rail, a fourth lead screw nut is threadedly connected on the fourth lead screw, and the flat-panel detector is fixedly connected to the fourth slider and the fourth lead screw nut through an adapter plate; the rotating disk is also provided with a second travel switch located on one side of the fourth sliding seat and used to limit the forward and backward sliding travel of the flat-panel detector.
10. The multimodal fusion imaging system according to any one of claims 1 to 5, characterized in that: The camera module includes a camera arranged on the top of the first dark box and irradiating toward the accommodating chamber, and a light source module arranged around the camera; the accommodating chamber is a hollow columnar structure with an opening at its upper end, and a transparent cover that can be opened and closed is provided at the opening.