Chemiluminescent Immunoassay Analyzer

Abstract

The utility model discloses a chemiluminescent immunoassay analyzer, comprising: at least one host, the host is used for detecting samples to be detected; a sample library, which is arranged at one side of the host and is arranged to extend along a first direction; the sample library comprises a library rack, the library rack is provided with a loading area, a recovery area and a buffer area, the loading area, the recovery area and the buffer area can store a plurality of sample racks, the sample racks are arranged side by side along the first direction, a plurality of samples are mounted on the sample racks, and the sample racks are configured to move horizontally on the library rack along the first direction; the loading area and the recovery area are arranged side by side along the first direction, and the buffer area is arranged below the loading area and the recovery area; the sample library is used for loading, information identification, buffering and recovery of samples to be detected; a track conveying mechanism, which is arranged at the other side of the host, and the track conveying mechanism is arranged to extend along a second direction; the track conveying mechanism comprises a first track and a second track which are arranged side by side and horizontally in sequence from near to far from the host.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection equipment, in particular to a chemiluminescent immunoassay analyzer. Background Art

[0002] The fully automatic chemiluminescence immunoassay analyzer is an in vitro diagnostic device that is clinically used to perform qualitative or quantitative detection of analytes in serum, plasma, and cerebrospinal fluid samples from the human body. It can be widely used in the laboratory and other departments of hospitals or research institutes for testing and analysis. Existing fully automatic chemiluminescence immunoassay analyzers generally manually add samples to their respective sample bins for sampling and testing, but due to the limited number of sample positions in each sample bin, it is difficult to adapt to continuous testing of large quantities of samples, which limits the speed and efficiency of the test. Utility Model Content

[0003] The purpose of the utility model is to provide a chemiluminescent immunoassay analyzer, which can store multiple sample racks by arranging a loading area and a recovery area above a buffer area, and dispatches and transports the samples to be tested to multiple hosts for testing through a lifting and dispatching trolley and a track conveying mechanism, so as to realize continuous testing of large quantities of samples, thereby improving the speed and efficiency of the test.

[0004] The embodiment of the utility model provides a chemiluminescent immunoassay analyzer, comprising: at least one host, the host is used to detect a sample to be tested; a sample library, which is arranged on one side of the host, and the sample library is arranged to extend along a first direction; the sample library comprises a library rack, the library rack is provided with a loading area, a recovery area and a buffer area, the loading area, the recovery area and the buffer area can store a plurality of sample racks, the sample racks are arranged side by side along the first direction, the sample racks are loaded with a plurality of samples, and the sample racks are configured to be able to move horizontally on the library rack along the first direction; the loading area and the recovery area are arranged side by side along the first direction, the buffer area is arranged The mainframe is provided with a first track and a second track which are arranged side by side and horizontally from near to far from the mainframe; wherein the first track is used to transport the sample rack containing the sample to be tested in the sample library to a preset position for sampling by the sample arm of the mainframe; and the second track is used to transport the sample rack which has completed the test to the recovery area of ​​the sample library; wherein the first direction and the second direction are perpendicular to each other.

[0005] Furthermore, the host includes a plurality of host computers, each of which is arranged side by side along the second direction; and the track conveying mechanism is independently arranged on one side of each host computer.

[0006] Furthermore, the track conveying mechanism also includes: a third track, which is located between the first track and the second track, and is used to quickly convey the sample rack containing the samples to be tested in the sample library to a preset position corresponding to the next host; a reversing trolley, which is located at one end of the track conveying mechanism away from the sample library, and the reversing trolley is configured to be able to move along a first direction to transfer the sample rack on the first track to the second track; or, the reversing trolley is used to transfer the sample rack containing the samples to be tested in the sample library via the third track of the previous host to the first track of the current host, and the sample rack is conveyed to the preset position of the current host via the first track for sampling by the sample arm of the current host; or, the reversing trolley is used to transfer the sample rack containing the samples to be tested in the sample library via the third track of the previous host to the third track of the current host, so as to be conveyed to the first track of the next host.

[0007] Furthermore, the sample library also includes: a lifting and scheduling trolley, which is arranged in the library frame, the lifting and scheduling trolley is located between the main machine and the loading area, and the lifting and scheduling trolley is configured to be able to move horizontally along the first direction and vertically along the third direction to transfer the sample rack stored in the loading area to the buffer area, and to realize the transfer of sample racks between the track conveying mechanism and the sample library; wherein the third direction is perpendicular to the first direction.

[0008] Furthermore, the lifting and scheduling trolley includes: a first base body; a first moving mechanism, which includes a first guide rail and a first slider, the first slider is connected and fixed to the bottom of the first base body, the first guide rail is configured to extend along a first direction, the first guide rail is installed on the bottom plate of the storage rack, and the first slider is adapted to the first guide rail so that the first base body can be horizontally moved along the first direction; a lifting frame, a scheduling track is provided on the top of which, the scheduling track is for the sample rack to pass or cache; a second moving mechanism, which includes a second guide rail and a second slider, the second guide rail extends along a third direction and is installed on the vertical plate of the first base body, the second slider is connected and fixed to the bottom of the lifting frame, and the first slider is adapted to the first guide rail so that the lifting frame can be vertically moved along the third direction.

[0009] Furthermore, the lifting and scheduling trolley also includes: a hook lifting mechanism, which includes a second base frame body and a hook assembly arranged on the second base frame body; wherein the hook assembly is configured to be able to move up and down along the second base frame body; a third moving mechanism, which includes a third guide rail and a third slider; the third guide rail extends along the second direction, and the third guide rail is installed on the bottom plate of the lifting frame; the third slider is installed at the bottom of the second base frame body, and the third slider is adapted to the third guide rail so that the second base frame body can move laterally along the second direction; wherein, when the hook assembly rises to the working position, the hook assembly is connected to the sample rack in the scheduling track at the top of the lifting frame, so that when the second base frame body moves laterally along the second direction, the hook assembly drives the sample rack in the scheduling track to move laterally; when the hook assembly descends to its original position, the hook assembly is separated from the sample rack in the scheduling track.

[0010] Furthermore, the hook lifting mechanism also includes: a driving assembly, mounted on the second base body; a cam assembly, including a cam arm and a pulley arranged on the cam arm, and the pulley is configured to be able to rotate around an axis; the cam arm is mounted on the driving assembly, and the driving assembly drives the cam arm to reciprocate and swing within a preset angle; wherein the outer peripheral surface of the pulley is pressed and contacted with the bottom of the hook assembly, so that the hook assembly moves up and down along the second base body when the cam arm reciprocates and swings; the rotation axis of the pulley and the rotation axis of the driving assembly are set to a predetermined distance.

[0011] Furthermore, the lifting and scheduling trolley also includes: a positioning mechanism, which is arranged at the top of the lifting frame, and is used to block the sample rack transported by the second track from entering the scheduling track at the top of the lifting frame, so as to achieve positioning of the sample rack in the scheduling track; the positioning mechanism includes: a positioning assembly, which includes a positioning member, and the positioning member is configured to be able to rotate and swing back and forth; wherein, when the positioning member rotates to the blocking position, the positioning member contacts the sample rack in the scheduling track to prevent the sample rack from passing through the scheduling track; when the positioning member rotates to the original position, the positioning member is away from the scheduling track to allow the sample rack to pass through the scheduling track.

[0012] Furthermore, a partition is provided on the shelf to separate the top layer of the shelf into a loading area and a recovery area; an emergency track is provided on the top layer of the shelf to accommodate and transport emergency sample racks, and the emergency track is arranged on the other side of the loading area away from the recovery area; an anti-misplacement mechanism is provided in the emergency track to detect whether the emergency sample rack is placed correctly.

[0013] Furthermore, the main machine includes: a frame body and a tube warehouse, a diluent bin, an incubation unit, a cleaning unit, a reagent bin, and a detection unit arranged on the frame body; the tube warehouse, the cleaning unit, and the reagent bin are arranged in sequence along the counterclockwise rotation direction of the incubation unit, and the cleaning unit is located between the detection unit and the incubation unit; the diluent bin is arranged to be located on the same side of the incubation unit as the tube warehouse; wherein the diluent bin includes a bin body, a plurality of spaced grooves can be arranged on the bin body, and a first container containing a diluent and a second container containing a first cleaning liquid are placed in the grooves; the bin body is configured to be able to move horizontally along a first direction; when the bin body is located in the operating position, the diluent is added to the first container and / or the first cleaning liquid is added to the second container; when the bin body is located in the working position, the sample injection needle on the sample arm of the main machine can absorb the diluent in the first container or the sample injection needle on the sample arm of the main machine can absorb the first cleaning liquid in the second container for cleaning.

[0014] The above technical solution of the utility model has the following beneficial technical effects:

[0015] 1. In the embodiment of the utility model, by arranging the loading area and the recovery area above the buffer area, the buffer area can store multiple sample racks, and the samples to be tested are dispatched and transported to multiple host computers for testing through the lifting and dispatching trolley and the track conveying mechanism, so as to realize continuous testing of large quantities of samples, which can improve the speed and efficiency of the test.

[0016] 2. In the embodiments of the utility model, each host can be used as a single machine, that is, one sample library is equipped with one track conveying mechanism and one host; or 2-4 hosts can be cascaded, that is, one sample library is equipped with 2-4 track conveying mechanisms and 2-4 hosts. According to the needs of different users, various combinations and flexible layouts can be realized to meet different application scenarios. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a structural schematic diagram of a chemiluminescent immunoassay analyzer according to the first embodiment of the utility model;

[0018] Figure 2 It is a schematic structural diagram of a host of a chemiluminescent immunoassay analyzer according to a second embodiment of the present utility model;

[0019] Figure 3 The structural diagram of the incubation unit is schematically shown;

[0020] Figure 4 is a schematic structural diagram of a chemiluminescent immunoassay analyzer according to a third embodiment of the present utility model;

[0021] Figure 5 is a schematic structural diagram of a sample library of a chemiluminescent immunoassay analyzer according to a fourth embodiment of the present utility model;

[0022] Figure 6 is a schematic structural diagram of a chemiluminescent immunoassay analyzer according to a fifth embodiment of the present utility model;

[0023] Figure 7 It is a structural schematic diagram of a lifting and dispatching trolley according to a sixth embodiment of the utility model;

[0024] Figure 8 It is a structural schematic diagram of a lifting and dispatching trolley according to a seventh embodiment of the utility model;

[0025] Fig. 9 It is a partial structural schematic diagram of a lifting and dispatching trolley according to an eighth embodiment of the utility model;

[0026] Fig.10 It is a schematic structural diagram of a hook lifting mechanism in a raised state according to a ninth embodiment of the utility model;

[0027] Fig.11 It is a schematic structural diagram of a hook lifting mechanism in a descending state according to a tenth embodiment of the utility model;

[0028] Fig.12 is a structural schematic diagram of a cam assembly according to an eleventh embodiment of the utility model;

[0029] Fig.13 is a schematic structural diagram of a positioning mechanism according to a twelfth embodiment of the present utility model;

[0030] Fig.14 is a schematic structural diagram of a positioning assembly according to the thirteenth embodiment of the present utility model;

[0031] Fig.15 is a schematic structural diagram of a blocking state of a positioning mechanism according to a fourteenth embodiment of the present utility model;

[0032] Fig.16 is a schematic structural diagram of a positioning assembly in a reset state according to a fifteenth embodiment of the present utility model;

[0033] Fig.17 It is a flow chart of a sample detection method according to the sixteenth embodiment of the present utility model. DETAILED DESCRIPTION

[0034] In order to make the purpose, technical solution and advantages of the utility model clearer, the utility model is further described in detail below in combination with specific implementation methods and with reference to the accompanying drawings. It should be understood that these descriptions are only exemplary and are not intended to limit the scope of the utility model. In addition, in the following description, the description of well-known structures and technologies is omitted to avoid unnecessary confusion of the concept of the utility model.

[0035] The first aspect of the utility model provides a chemiluminescent immunoassay analyzer, such as Figure 1 , Figure 4-Figure 6 As shown, it includes: at least one host 100, a sample library 300 and a track conveying mechanism 400. The host 100 is used to detect samples to be tested; the sample library 300 is arranged on one side of the host 100, and the sample library 300 is arranged to extend along a first direction; the sample library 300 includes a library rack 310, and the library rack 310 is provided with a loading area, a recovery area and a buffer area, and the loading area, the recovery area and the buffer area can store multiple sample racks 260, the sample racks 260 are arranged to be arranged side by side along the first direction, and the sample racks 260 are equipped with multiple samples, and the sample racks 260 are configured to be able to move horizontally on the library rack 310 along the first direction; the loading area and the recovery area are arranged to be arranged side by side along the first direction, and the buffer area is arranged below the loading area and the recovery area; the sample library 300 is used to detect samples to be tested; The loading, information identification, caching and recovery of the samples to be tested of the host 100; a track conveying mechanism 400, which is arranged on the other side of the host 100, and the track conveying mechanism 400 is arranged to extend along the second direction; the track conveying mechanism 400 includes a first track 410 and a second track 420 which are arranged side by side and horizontally from near to far away from the host 100; wherein the first track 410 is used to convey the sample rack 260 containing the samples to be tested in the sample library 300 to a preset position for sampling by the sample arm of the host 100; the second track 420 is used to convey the sample rack 260 which has completed the test to the recovery area of ​​the sample library 300; wherein the first direction and the second direction are perpendicular to each other.

[0036] In the embodiment of the utility model, the first direction is, for example, the Y direction in the coordinate system, the second direction is, for example, the X direction, and the third direction is, for example, the Z direction. In order to facilitate the operation of the host 100 by the staff, when the staff stands on one side of the host 100 to operate, the side can be defined as the front side; the track conveying mechanism 400 can be set to be located at the rear side of the host 100, the sample library 300 is set on the left or right side of the host 100, and the loading area and the recycling area can be set to be front and back.

[0037] In some embodiments, the sample rack 260 may be configured to be approximately in the shape of a rectangular parallelepiped, and the sample rack 260 includes a sample rack body, on which a plurality of sample tube placement holes are provided at intervals, into which sample tubes may be inserted and fixed. A longitudinally extending notch may be provided on one side of each sample tube placement hole, and the identification code on the sample tube may face the notch to facilitate detection by a barcode scanner and / or a photoelectric sensor.

[0038] In some embodiments, a partition may be provided on the shelf 310 to separate the top layer of the shelf 310 into a loading area and a recycling area. The loading area may be provided with a loading basket 320, and the recycling area may be provided with a recycling basket 330, so as to facilitate the loading and recycling of the sample rack 260. The loading basket may include a frame body, wherein the frame body has a storage space, and the storage space is used to load a plurality of sample racks; a first slide and a second slide extending along a first direction are provided on the frame body, and the first slide and the second slide are provided on both sides, and the first slide is located on the side wall of the frame body, and the second slide is located on the bottom plate of the frame body; wherein the first slide and the second slide can both be configured as guide rails; a first slot is provided on the left side of the sample rack body, and the first slot extends rightward into the sample rack body along the length direction of the sample rack body, and the first slot is adapted to the first slide; a second slot is provided at the bottom of the sample rack body, and the second slot extends upward into the sample rack body along the height direction of the sample rack body, and the second slot is located on the right side close to the sample rack body, and the second slot is adapted to the second slide; the sample rack body The right side of the body may be provided with a recessed portion, which extends downward to the bottom of the sample rack body; when multiple sample rack bodies are arranged side by side and are loaded in the loading basket in sequence, the sample rack can be prevented from being placed incorrectly; for example, when the sample rack is correctly installed in the loading basket, the identification codes of the sample tubes on the sample rack are all facing the front side, and the sample rack can be prevented from tipping over in the front-to-back direction after being installed in the loading basket; the right side of the sample rack body is provided with a recessed portion, and if the sample rack is reversed during installation, the identification codes of the sample tubes on the sample rack are all facing the rear side, and the recessed portion cannot be matched with the first slideway of the basket, and the sample rack body is placed on the first slideway, and the sample rack body is tilted, which indicates that the sample rack is not installed correctly, so the first slot and the recessed portion can be used together to prevent the sample rack from being loaded into the loading basket. Therefore, when the sample rack is manually placed in the loading basket, there is a relatively obvious distinction between the front and back placement, so that when the sample rack is pushed into the instrument, various interference problems can be avoided, thereby ensuring the accuracy of the instrument's detection of the sample. When the second slot is not arranged on the longitudinal center line of the sample rack body in the length direction, the second slot and the first slot can be used together to further prevent the sample rack from being loaded into the loading basket; the loading basket 320 can be installed in the loading area, and the recovery basket 330 can be installed in the recovery area. The structure of the recovery basket 330 can be set to be the same as that of the loading basket 320; a pushing device can be arranged on the shelf 310 to push the sample rack body to move along the first slide and the second slide. A third slide can be arranged in the loading area, the third slide extends along the second direction, and the third slide can be arranged on the side close to the recovery area, and the third slide is connected to the first slide; when the pushing device pushes the sample rack 260 into the second slide, the driving device arranged on the second slide is started to transfer the sample rack 260 to the lifting and dispatching trolley 500 that has moved to the corresponding position to receive the sample rack 260.A barcode scanner or photoelectric sensor may be provided on the library rack 310 to scan and identify the identification codes on each sample tube on the sample rack 260 to be moved into the lifting and scheduling trolley 500, so as to identify and upload the sample information in each sample tube. The lifting and scheduling trolley 500 moves downward along the third direction to transfer the sample rack 260 to the buffer area. The buffer area can store multiple sample racks 260, so that the samples to be tested can be scheduled and transported to multiple hosts for testing through the lifting and scheduling trolley and the track conveying mechanism 400, so as to realize continuous testing of large quantities of samples, which can improve the speed and efficiency of the test.

[0039] In some embodiments, the host includes a plurality of hosts, each of which is arranged side by side along the second direction; the track conveying mechanism 400 is independently arranged on one side of each host. Specifically, each host can be used alone, that is, one sample library is equipped with one track conveying mechanism 400 and one host; or 2-4 hosts can be cascaded, that is, one sample library is equipped with 2-4 track conveyors and 2-4 hosts. According to the needs of different users, various combinations and flexible layouts can be realized to meet different application scenarios. As the realization of the two main functions of loading and recycling test samples, the sample library can be set on the right side of the instrument, with sufficient space and more convenient user operation; at the same time, the buffer area is located directly below the loading area and the recycling area to save space.

[0040] In some embodiments, the track conveying mechanism 400 further includes: a third track 430, which is located between the first track 410 and the second track 420, and is used to quickly convey the sample rack 260 containing the sample to be tested in the sample library 300 to a preset position corresponding to the next host; a reversing trolley 440, which is located at one end of the track conveying mechanism 400 away from the sample library 300, and the reversing trolley 440 is configured to be able to move along a first direction to transfer the sample rack 260 on the first track 410 to the second track 420; or The reversing trolley 440 is used to transfer the sample rack 260 containing the sample to be tested in the sample library 300 to the first track 410 of the current host through the third track 430 of the previous host, and the sample rack 260 is transported to the preset position of the current host through the first track 410 for sampling by the sample arm of the current host; or, the reversing trolley 440 is used to transfer the sample rack 260 containing the sample to be tested in the sample library 300 to the third track 430 of the current host through the third track 430 of the previous host, so as to be transported to the first track 410 of the next host. Specifically, the first track 410 may include a first baffle and a second baffle that are relatively parallel and spaced apart, the first baffle and the second baffle extend along the second direction, and the gap between the first baffle and the second baffle constitutes a slide, the slide can allow the sample rack 260 to pass through, and the width of the slide is set to be slightly larger than the width of the sample rack 260. A conveyor mechanism may be provided at the bottom of the first track 410 to provide power for the transportation of the sample rack 260. Similarly, the arrangement structure of the second track 420 and the third track 430 is the same as that of the first track 410, and will not be repeated here. The reversing trolley 440 may include a first base frame and a first sliding mechanism. Among them, the first sliding mechanism includes a first driving device, a first slide rail and a first guide block, the first guide block is connected and fixed to the bottom of the first base frame, the first slide rail is configured to extend along the first direction, and the first slide rail is adapted to the first guide block so that the first base frame moves horizontally forward and backward along the first direction. The first driving device is used to drive the reversing trolley 440 to move horizontally forward and backward along the first slide rail. The first driving device can be, for example, a transmission device such as a motor-driven synchronous belt or chain, which is not limited too much here. A transfer track can be provided on the top of the base frame, and the sample rack 260 can be accommodated and / or transported in the transfer track. A conveyor belt mechanism can also be provided at the bottom of the transfer track to provide power for the transportation of the sample rack 260. The second track 420 is used to recycle the sample rack 260 after the test to the designated position, and the first track 410 is used to receive the sample rack 260 transported by the lifting and scheduling trolley 500 and transport it to the designated position for the sample arm to take the sample; the third track 430 is set as a fast track, which is used to receive the sample rack 260 transported by the lifting and scheduling trolley 500 and quickly transport it to the first track 410 on the second host, or the third host, or the fourth host; the transmission directions of the first track 410 and the second track 420 can be set to be opposite, and the first track 410 and the third track 430 can be set to be the same.

[0041] In some embodiments, the top layer of the library rack 310 may be provided with an emergency track 340 for accommodating and transporting the emergency sample rack, and the emergency track 340 is arranged on the other side of the loading area away from the recovery area. When the emergency sample rack is manually placed, if there is no obvious distinction between the front and back, once the emergency sample rack is reversed and pushed into the machine, various interference problems will occur; in view of this, the present application may be provided with an anti-misplacement mechanism in the emergency track 340 to detect whether the emergency sample rack is correctly placed. The anti-misplacement mechanism includes a first Hall sensor, and a magnet may be provided at the bottom of the emergency sample rack. When the magnet is close to the first Hall sensor, the first Hall sensor senses the magnet, that is, the first Hall sensor detects that the emergency sample rack is in place, and then the pushing mechanism is started to push the emergency sample rack into the machine, that is, the emergency sample rack is pushed into the lifting and dispatching trolley 500 that has been moved to the corresponding position to receive the emergency sample rack, and then the lifting and dispatching trolley 500 is transferred to the track conveying mechanism 400. When the emergency sample rack is not placed correctly, the first Hall sensor cannot sense the magnet, that is, the first Hall sensor cannot detect that the emergency sample rack is in place. At this time, the pushing mechanism will not be started, and the emergency sample rack will not be pushed into the machine. The specific structural dimensions of the emergency sample rack can be set to be the same as the specific structural dimensions of other sample racks. The emergency track is set on the sample library. For samples that need to be tested urgently, they can be dispatched and directly enter the lifting and dispatching trolley 500 for transfer to the track conveying mechanism 400 to be transported to the sampling position 2a of the corresponding host to meet more application needs of users.

[0042] In some embodiments, the sample library 300 further includes: a lifting and scheduling trolley 500, which is disposed in the library rack 310, and the lifting and scheduling trolley 500 is located between the main machine 100 and the loading area, and the lifting and scheduling trolley 500 is configured to be able to move horizontally along the first direction and vertically along the third direction, so as to transfer the sample rack 260 stored in the loading area to the buffer area, and realize the transfer of the sample rack 260 between the track conveying mechanism 400 and the sample library 300; wherein, the third direction is perpendicular to the first direction.

[0043] In some embodiments, reference Figure 7-Figure 9The lifting and dispatching trolley 500 includes a first frame body 510 and a first moving mechanism 520. The first frame body 510 includes a vertical plate and a first bottom plate perpendicular to the vertical plate; the first moving mechanism 520 includes a first guide rail and a first slider, the first slider is connected and fixed to the bottom of the first frame body 510, the first guide rail is set to extend along the first direction, the first guide rail can be installed on the bottom plate of the storage rack 310, and the first slider is adapted to the first guide rail so that the first frame body 510 moves horizontally forward and backward along the first direction. The first moving mechanism 520 also includes a first power device, which is used to drive the first frame body 510 to move horizontally forward and backward along the first direction. The first power device includes a first motor, a first synchronous belt, a first transmission wheel and a first driven wheel. The output shaft of the first motor is connected to the first transmission wheel to drive the first transmission wheel to rotate; the first transmission wheel and the first driven wheel can be installed on the bottom plate of the storage rack 310, and are respectively located at the front and rear ends of the first guide rail. The first synchronous belt can be sleeved on the first transmission wheel and the first driven wheel. The first base body 510 and the first synchronous belt can be connected and fixed by a first transition component, so that the first synchronous belt drives the first base body 510 to move horizontally forward and backward along the first direction; wherein, the first transition component may include a first clamping block and a second clamping block, the first clamping block can be fixed on the first base body 510, and the second clamping block is arranged on the first synchronous belt, and the first clamping block and the second clamping block are connected and fixed by threaded fasteners.

[0044] In some embodiments, the lifting and dispatching trolley 500 may further include a lifting frame 540 and a second moving mechanism 560, wherein the second moving mechanism 560 includes a second guide rail, a second slider adapted to the second guide rail, and a second power device. The second guide rail extends along the third direction and may be mounted on the vertical plate of the first pedestal body 510, and the second guide rail may be disposed on the rear side of the first pedestal body 510, so that the overall structure is compact and space is effectively utilized. The second slider may be provided with a first connecting member and a second connecting member, and the first connecting member and the second connecting member may be disposed on the left and right sides of the second slider, and the first connecting member and the second connecting member pass through the vertical plate of the first pedestal body 510 and are connected and fixed to the bottom of the lifting frame 540. The second slider moves longitudinally up and down along the second guide rail, thereby driving the lifting frame 540 to lift up and down. In order to facilitate the lifting frame 540 to lift up and down, an elongated through groove may be disposed on the vertical plate of the first pedestal body 510, so that the first connecting member and the second connecting member can pass smoothly. Similarly, the second power device includes a second motor, a second synchronous belt, a second transmission wheel and a second driven wheel. The output shaft of the second motor is connected to the second transmission wheel to drive the second transmission wheel to rotate. The second motor can be installed on the front side of the first base body 510; the second driven wheel and the second transmission wheel can both be installed on the vertical plate of the first base body 510, and are respectively located at the upper and lower ends of the second guide rail. The second synchronous belt can be sleeved on the second transmission wheel and the second driven wheel. The second synchronous belt can be provided with a second transition piece, and the second transition piece is in contact with the inner tooth surface of the second synchronous belt. The second transition piece is connected and fixed to the first connecting piece by threaded fasteners.

[0045] In some embodiments, a scheduling track 541 is provided on the top of the lifting frame 540. The scheduling track 541 may include two third baffles that are relatively parallel and spaced apart. The gap between the two third baffles constitutes a slide groove, and the slide groove allows the sample rack 260 to pass through. The width of the slide groove is set to be slightly larger than the width of the sample rack 260.

[0046] In an exemplary embodiment, the lifting frame 540 may include a column, a top plate and a bottom plate spaced apart from each other, and both ends of the column are respectively connected and fixed to the top plate and the bottom plate, and may be connected and fixed by welding or threaded fasteners, which is not further limited here.

[0047] In some embodiments, the lifting and dispatching trolley 500 may further include a hook lifting mechanism 550 and a third moving mechanism 570 . Fig.10 It is a schematic diagram of the structure of the hook lifting mechanism in the raised state according to an embodiment of the present application. Fig.11 1 is a schematic diagram of the structure of the hook lifting mechanism in the descending state according to an embodiment of the present application. Fig.10 and Fig.11As shown, the hook lifting mechanism 550 includes a second pedestal body 551, a first driving assembly 552, a cam assembly 553 and a hook assembly 554. The first driving assembly 552 is mounted on the second pedestal body 551; the cam assembly 553 includes a cam arm and a pulley arranged on the cam arm, and the pulley is configured to be able to rotate around an axis; the cam arm is mounted on the first driving assembly, and the first driving assembly drives the cam arm to reciprocate and swing within a preset angle; the hook assembly 554 is arranged on the second pedestal body, and the outer peripheral surface of the pulley is pressed and contacted with the bottom of the hook assembly, so that the hook assembly moves up and down along the second pedestal body 551 when the cam arm reciprocates and swings; wherein the rotation axis of the pulley is set to a predetermined distance from the rotation axis of the first driving assembly. The first driving assembly 552 can be installed at the center of the cam arm, and when the first driving assembly 552 drives the cam arm to rotate and swing, the cam assembly 553 rotates and swings around the rotation axis of the first driving assembly.

[0048] In some embodiments, the third moving mechanism 570 includes a third guide rail, a third slider matched with the third guide rail, and a third power device. The third guide rail extends along the second direction and can be installed on the bottom plate of the lifting frame 540. The third slider is installed at the bottom of the second base body, and when the third slider slides along the third guide rail, it can drive the second base body to move horizontally left and right. Similarly, the third power device includes a third motor, a third synchronous belt, a third transmission wheel and a third driven wheel. The output shaft of the third motor is connected to the third transmission wheel to drive the third transmission wheel to rotate. The third transmission wheel and the third driven wheel can be installed on the bottom plate of the lifting frame 540 and are respectively located at the left and right ends of the third guide rail. The third synchronous belt can be sleeved on the third transmission wheel and the third driven wheel. The second base frame body and the third synchronous belt can be connected and fixed by a third transition component, so that the third synchronous belt drives the second base frame body to move horizontally in the second direction. The third transition component may include a third clamping block and a fourth clamping block. The third clamping block can be fixed on the second base frame body, and the fourth clamping block is arranged on the third synchronous belt. The third clamping block and the fourth clamping block are connected and fixed by threaded fasteners. In order to save space, the third motor can be suspended and installed at the bottom of the lifting frame 540, so that the stroke of the horizontal movement of the hook lifting mechanism 550 can also be extended.

[0049] The cam assembly 553 includes a cam arm 5531, a pulley 5532 and a rotating shaft 5533 disposed on the cam arm 5531. The rotating shaft 5533 is a supporting shaft of the pulley 5532. The pulley 5532 is fixed to the cam arm 5531 by the rotating shaft 5533. The pulley 5532 may be a circular wheel mounted on the cam arm 5531 and may rotate around the rotating shaft 5533. In one embodiment, the pulley 5532 is, for example, a bearing, and the inner ring of the bearing is connected and fixed to the rotating shaft 5533. The bearing is used to convert the rotational motion into the linear up-and-down motion of the hook assembly 554, thereby improving the motion stability of the hook assembly 554.

[0050] The hook assembly 554 is movably disposed on the second base body 551, and the outer peripheral surface of the pulley 5532 is pressed against the bottom of the hook assembly 554, so that the hook assembly 554 moves up and down along the second base body 551 when the cam arm 5531 reciprocates and swings. Fig.10 The bottom of the hook assembly 554 is a flat plate structure, which provides good conditions for the rotation of the pulley 5532, reduces the friction resistance of the pulley, and the outer peripheral surface of the pulley 5532 can always be pressed against the bottom of the hook assembly 554. In one embodiment, the hook assembly 554 includes: a hook 5541, which is a U-shaped structure, that is, a connecting part is provided on both sides of the hook 5541, and the connecting part is, for example, a bump protruding upward. The connecting parts on both sides can cooperate with the openings on the left and right ends of the sample rack to achieve the longest distance transmission function of the sample rack. Because the hook lifting mechanism moves left and right along the third guide rail, the design length of the third guide rail is limited by space. The design of multiple connecting parts and openings on both ends of the sample rack solves the problem of the short transportation distance of the sample rack caused by the design length of the third guide rail being limited by space; and it is conducive to saving the length of the dispatching track and the lifting frame, reducing the occupied space of the lifting and dispatching trolley and saving manufacturing costs.

[0051] The hook assembly 554 works in conjunction with the cam assembly 553 to form a mechanism for controlling the vertical movement of the hook assembly 554 on the second pedestal body 551. Specifically, the first drive assembly 552 drives the cam arm 5531 to reciprocate and rotate around its axis, and the pulley 5532 is fixed to one end of the cam arm 5531 and can rotate around the rotating shaft 5533. When the cam arm 5531 swings, the pulley 5532 also rotates. The pulley 5532 contacts the bottom of the second pedestal body 551, and as the cam arm 5531 rotates and swings, the outer edge of the pulley 5532 pushes the hook assembly 554 to move up and down along the guide rail of the second pedestal body 551. Through the cooperation of the first drive assembly 552, the cam assembly 553 and the hook assembly 554, the precise up and down movement of the hook assembly 554 can be achieved, which is very suitable for the use scenario that requires reciprocating motion in the vertical direction. Through reasonable design, it can ensure that the mechanism operates smoothly and reliably under various working conditions.

[0052] According to an embodiment of the present application, the first driving assembly 552 drives the cam arm 5531 to rotate in the counterclockwise direction until the cam arm 5531 abuts against the stopper 5512 of the second base body, so that the pulley 5532 lifts the hook assembly 554, and the hook assembly 554 is in the ascending position. The stopper 5512 protrudes from the rotation plane of the cam arm 5531, and the stopper 5512 can be a ridge. The ridge is used to prevent the cam arm 5531 from continuing to rotate. When the cam arm 5531 abuts against the ridge, the preset angle of rotation of the cam arm 5531 is an obtuse angle, that is, the angle between the center of the pulley 5532 and the center of the first driving assembly 552 and the horizontal line is greater than 90 degrees, and the pulley 5532 is not at the highest point. When the cam arm 5531 rotates at an obtuse angle, the cam assembly 553 has three stress points, namely, the stress point between the pulley 5532 and the bottom of the hook assembly 554, the stress point at the fixed connection between the cam arm 5531 and the first drive assembly 552, and the stress point where the cam arm 5531 contacts the convex ridge. The three stress points form a stable stress triangle. Even when the first drive assembly 552 is powered off and no longer applies driving force, the cam arm 5531 will still support the hook assembly 554 in a jacking state, realizing the power-off holding function. At this time, the hook of the hook assembly 554 is inserted into the opening at the bottom of the sample rack, dragging the sample rack to move horizontally left and right in the scheduling track.

[0053] refer to Fig.11 When the first driving assembly 552 drives the cam arm 5531 to rotate in a clockwise direction until the pulley is lower than the highest point, the hook assembly 554 is in a state of descending by gravity.

[0054] like Fig.10As shown, the hook lifting mechanism 550 also includes: an elastic component 555, which is arranged between the hook component 554 and the second base body 551. When the hook component 554 descends, the elastic component 555 applies downward pressure to the hook component 554. Among them, the elastic component 555 can be a compression spring. When the hook component 554 rises, the spring is compressed and stores energy. When the hook component 554 descends, the spring resets and releases the stored energy to help the hook component fall back quickly, avoiding the uncertainty of the hook component 554 falling back only by gravity. In addition, since part of the energy is provided by the spring during the descent process, the power required by the first drive component 552 during the descent process can be reduced, thereby reducing energy consumption. When the hook component 554 is in the descending position, the hook of the hook component 554 is separated from the bottom of the sample rack.

[0055] According to one embodiment of the present application, the hook lifting mechanism 550 also includes: a sensor assembly 556, a control unit electrically connected to the first drive assembly 552 and the sensor assembly 556 respectively, the sensor assembly is used to send a monitoring signal to the control unit, and the control unit sends a control signal to the first drive assembly 552 to drive the cam arm 5531 to rotate and swing back and forth.

[0056] In some embodiments, the hook lifting mechanism 550 further includes: a guiding mechanism, which includes a fourth guide rail and a fourth slider; the fourth guide rail extends along the third direction, and the fourth guide rail is installed on the second base frame body 551, the fourth slider is connected to the hook assembly, and the fourth slider is adapted to the fourth guide rail, so that the hook assembly moves up and down along the second base frame body. Through the guidance of the fourth guide rail, the hook lifting mechanism 550 can move up and down more smoothly.

[0057] Fig.12 is a schematic diagram of the structure of a cam assembly according to an embodiment of the present application. Fig.11 and Fig.12 As shown, the sensor assembly 556 includes: a first sensor 5561 fixed on the second pedestal body 551, when the hook assembly 554 is in the descending state, the first blocking portion 5534 of the cam assembly senses the first sensor 5561. The sensor assembly 556 further includes: a second sensor 5562 fixed on the second pedestal body 551, when the hook assembly 554 is in the ascending state, the second blocking portion 5535 of the cam assembly senses the second sensor. The first blocking portion 5534 and the second blocking portion 5535 are both arranged on the cam arm 5531 and away from one end of the rotating shaft 5533, and the first blocking portion 5534 and the second blocking portion 5535 are sheet structures.

[0058] According to one embodiment of the present application, the first sensor 5561 and / or the second sensor 5562 is an optical coupling sensor, which uses light to detect the first blocking portion 5534 or the second blocking portion 5535. The optical coupling sensor includes a light emitting end and a receiving end. When the first blocking portion 5534 or the second blocking portion 5535 is located between the light emitting end and the receiving end, it will affect the receiving end from receiving the light. The position information of the cam arm 5531 is determined based on whether the receiving end receives the light, and then it is determined whether the hook assembly is in a raised or lowered state. The control unit can adjust the swing direction of the cam arm 5531 in real time according to the position signal sent by the sensor assembly 556, thereby achieving precise position control and motion control.

[0059] refer to Fig.12 , a concave surface 5536 is cut at one end of the cam arm 5531 mounting shaft 5533, and the concave surface 5536 contacts the stopper to stop the cam arm from rotating counterclockwise. While the concave surface contacts the stopper to limit the cam arm from continuing to rotate, the pulley 5532 can be allowed to reach a larger rotation angle, thereby increasing the range of motion of the entire cam arm. The contact between the concave surface 5536 and the stopper can provide a larger contact area than other forms of contact (such as point contact or edge contact), which can increase the stability of the contact, reduce wear, and improve the reliability and service life of the cam assembly 553.

[0060] The guide rails in the above embodiments may be linear guide rails, and the power device may be a transmission member such as a synchronous belt or chain that can transmit power. Correspondingly, the driving wheel and the driven wheel may be pulleys or sprockets that mesh with the synchronous belt or chain.

[0061] In some embodiments, the lifting and scheduling trolley 500 also includes: a positioning mechanism 530, which is arranged at the top of the lifting frame 540, and is used to block the sample rack 260 transported by the second track 420 from entering the scheduling track 541 at the top of the lifting frame 540, so as to achieve the positioning of the sample rack 260 in the scheduling track 541; the positioning mechanism includes: a positioning assembly, which includes a positioning member, and the positioning member is configured to be able to rotate and swing back and forth; wherein, when the positioning member rotates to the blocking position, the positioning member contacts the sample rack 260 in the scheduling track 541, preventing the sample rack 260 from passing through the scheduling track 541; when the positioning member rotates to the original position, the positioning member is away from the scheduling track 541, so as to allow the sample rack 260 to pass through the scheduling track 541.

[0062] The positioning mechanism 530 is arranged on the lifting frame 540 and is located at one end of the scheduling track 541 close to the track conveying mechanism 400, and is used to locate the conveying position of the sample rack. Furthermore, the positioning mechanism 530 is located close to the end of the second track 420. When the conveyor belt on the second track 420 uses friction to convey the sample rack to the end of the second track 420, when the conveyor belt continues to work, the sample rack 260 enters the scheduling track 541 due to inertia, and the positioning mechanism 530 prevents the sample rack from continuing to move forward, and temporarily stops the sample rack at a preset position, thereby realizing the precise positioning of the sample rack.

[0063] refer to Figure 1 and Figure 6 When the lifting and dispatching trolley moves forward and backward, it switches between the first track, the second track and the third track to achieve docking with different tracks. The hook lifting mechanism 550 is set at the bottom of the dispatching track 541, and is used to drive the sample rack to move horizontally along the first direction in the dispatching track 541. Taking the example of moving the sample rack after sample detection from the second track 420 to the dispatching track 541, the conveyor belt on the second track 420 conveys the sample rack to the right, and relying on the friction between the sample rack and the conveyor belt, at least a part of the sample rack enters the dispatching track 541. At this time, the positioning mechanism 530 prevents the sample rack from moving along the first direction. At this time, the sample rack can be accurately parked at the preset position. Then, the hook lifting mechanism 550 is moved to the bottom of the sample rack, the driving assembly 552 is started, the hook assembly 554 is lifted up and placed in the ascending position, the driving assembly 552 stops rotating, the hook assembly 554 remains in the ascending position, the hook (the protrusion on the left) on the hook assembly 554 is inserted into the right opening at the bottom of the sample rack, the hook lifting mechanism 550 moves rightward along the second direction, the positioning mechanism 530 is reset, allowing the sample rack to continue to move rightward, and the hook lifting mechanism 550 moves the sample rack completely into the scheduling track 541. Figure 6 and Figure 7 , the hook lifting mechanism 550 moves to the rightmost end of the third moving mechanism 570 and stops, at which time the driving assembly 552 is started again, and the hook assembly 554 reaches the highest point and then drops to the low position by gravity and the tension of the spring return, and the hook on the hook assembly 554 is separated from the sample rack. The hook lifting mechanism 550 moves to the left, referring to Fig. 9 , the hook lifting mechanism 550 moves to the left end of the third moving mechanism 570, at this time the driving assembly 552 is started again, the hook assembly 554 is lifted up and is in the rising position, the hook (the protrusion on the right) on the hook assembly 554 is inserted into the left opening at the bottom of the sample rack, the hook lifting mechanism 550 moves to the right along the second direction to the maximum stroke to the right end of the third moving mechanism 570 and stops, the sample rack is pushed into the recovery area of ​​the sample library, and the hook assembly 554 drops to a low position and detaches from the sample rack.

[0064] There are many ways to achieve the positioning of the sample rack on the second track 420. For example, a pusher can be installed on the second track 420, and the sample rack can be completely pushed into the scheduling track 541 by using the pusher. However, the use of the pusher invisibly adds more structural parts and requires a power source, which increases the complexity of the structure and may bring additional maintenance and failure points. Therefore, the present application sets a positioning mechanism 530 at one end of the scheduling track, and the precise positioning of the sample rack can be achieved by only driving the positioning member to achieve the blocking and reset states. Compared with the solution of installing a pusher, the present application can achieve precise positioning of the sample rack by setting the positioning mechanism 530, which is beneficial to the overall control of the equipment and makes the overall structure simple, and has the advantages of high reliability and low cost.

[0065] Fig.13 It is a schematic diagram of the positioning mechanism structure according to an embodiment of the present application. Fig.14 FIG. 1 is a schematic diagram of the structure of a positioning component according to an embodiment of the present application. Fig.13 and Fig.14 As shown, the positioning mechanism 530 includes: a positioning body 531, a positioning assembly 532 and a second driving assembly 533. The positioning body 531 can be installed on the lifting frame. The installation position of the positioning body 531 can be used to determine the positioning position of the sample rack.

[0066] The positioning assembly 532 includes a positioning body 5321 and a positioning member 5322, wherein the positioning member 5322 may be a positioning hook for hooking the sample rack to prevent the sample rack from moving forward. The positioning member 5322 is fixedly connected to the positioning body 5321 and forms a preset angle θ, wherein the preset angle θ between the positioning member 5322 and the positioning body 5321 is 130°-160°. The size of the angle between the positioning member 5322 and the positioning body 5321 will determine the positioning effect of the positioning mechanism. If the angle is too small, when the positioning assembly is in the reset state, it will still block the sample rack from passing through; if the angle is too large, when the positioning assembly is in the blocking state, it may not be able to effectively block the sample rack from moving further. Therefore, designing the angle θ between the positioning member 5322 and the positioning body 5321 within the range of 130°-160° will effectively achieve the blocking and resetting states of the positioning mechanism.

[0067] The positioning body 5321 is provided with a limiting hole 5323 and an assembly hole 5324, and the limiting hole 5323 is mounted on the positioning body 531 in cooperation with the limiting shaft 534. Furthermore, the limiting shaft 534 is fixed on the positioning body 531 in cooperation with the limiting hole 5323 by using a mounting sheet metal 535. The mounting sheet metal 535 is a C-shaped sheet metal part, and the mounting sheet metal 535 provides vertical support for the limiting shaft. The limiting shaft 534 and the limiting hole 5323 cooperate with each other, so that the positioning assembly 532 can rotate around the limiting shaft 534. The second driving assembly 533 is fixed on the positioning body 531, and the second driving assembly 533 is movably connected with the assembly hole 5324. The second driving assembly 533 telescopically moves along a straight line, and uses the principle of lever. When the positioning assembly 532 reciprocates around the limiting shaft 534, the positioning member 5322 presents two states of protruding from the positioning mechanism and not protruding from the positioning assembly, thereby realizing the blocking state and the reset state of the positioning mechanism.

[0068] According to one embodiment of the present application, the positioning assembly 532 also includes: a sensing portion 5325 for detecting the dynamic position of the positioning assembly, which is fixedly connected to the positioning body 5321. The sensing portion 5325 can be a plate-like structure with a curved edge. Designing the edge of the sensing portion 5325 as a smooth curve can effectively prevent spatial conflicts with other structures during rotation. In one embodiment, the end of the positioning member 5322 extending outward is provided with a chamfer 5326. The positioning member 5322 is used to contact the sample rack to prevent it from moving forward. The end of the positioning member 5322 extending outward is chamfered to avoid damage to the sample rack during contact with the sample rack.

[0069] Fig.15 It is a schematic diagram of the blocking state structure of the positioning mechanism according to an embodiment of the present application. Fig.16 FIG. 1 is a schematic diagram of the reset state structure of the positioning component according to an embodiment of the present application. Figure 5 and Figure 6 As shown, the second driving component 533 can perform reciprocating telescopic motion in a straight line. When the second driving component 533 contracts, the driving positioning member 5322 rotates counterclockwise around the limiting axis 534 to a blocking state. At this time, the positioning member 5322 protrudes from the positioning mechanism, so that the positioning member 5322 contacts the sample rack, preventing the sample rack from passing through the scheduling track; when the second driving component 533 extends, the driving positioning member 5322 rotates clockwise around the limiting axis 534 to a reset state. At this time, the positioning member 5322 is retracted into the range of the positioning mechanism, allowing the sample rack whose samples have completed detection to pass from the second track into the scheduling track.

[0070] According to an embodiment of the present application, the positioning mechanism further includes: a sensor assembly, which includes: a third sensor 536 and a fourth sensor 537 arranged corresponding to the sensing portion 5325, the third sensor 536 and the fourth sensor 537 are respectively fixed on the positioning body 531, when the sensing portion 5325 is located within the detection range of the third sensor 536, the positioning member 5322 is in a reset state; when the sensing portion 5325 is located within the detection range of the fourth sensor 537, the positioning member 5322 is in an extended state. The third sensor 536 and the fourth sensor 537 can be optical coupling sensors, and the optical coupling sensor includes a transmitting end and a receiving end arranged oppositely, the transmitting end sends light to the receiving end, and when the sensing portion 5325 is located between the transmitting end and the receiving end, the receiving end will not be able to receive light to judge the state of the positioning member 5322.

[0071] According to one embodiment of the present application, the second drive component 533 is a push-pull electromagnet, which includes a coil (not shown) and an iron core 5331, one end of which is movably connected to the assembly hole by a pin shaft. When the coil is energized, the iron core 5331 is attracted to generate a thrust or a pull; after power is off, the iron core 5331 returns to its original position under the action of a spring or other reset force. In another embodiment, the push-pull electromagnet is a bistable push-pull electromagnet, which has two stable states. When the coil is energized, the iron core 5331 is attracted to one end to generate a thrust or a pull; when the current in the coil is reversed, the iron core 5331 is attracted to the other end, and the direction of the thrust or the pull is opposite. The bistable push-pull electromagnet can maintain its attracted state at one end until the coil at the other end is energized. The push-pull electromagnet can respond quickly after the current is turned on to achieve the attraction and release of the iron core, which is very suitable for occasions requiring a quick response. Due to the push-pull structure, the movement of the electromagnet is very accurate, and the stroke and force can be precisely controlled to meet high-precision work requirements. Compared with other types of electromagnets, the push-pull electromagnet has smooth movement and small impact, so its mechanical parts have less wear and tear and a longer service life.

[0072] According to one embodiment of the present application, the positioning mechanism also includes: one or more bearings 538, the outer ring of the bearing 538 is installed in the limiting hole, and the bearing 538 is fixedly connected to the limiting shaft 534. Among them, the bearing 538 is used to support the rotation of the positioning assembly 532, reduce friction and wear, and ensure the accuracy and stability of the positioning assembly 532. In one embodiment, the positioning mechanism includes two flanged deep groove ball bearings, which are respectively arranged at the upper and lower ends of the limiting hole. Using two flanged deep groove ball bearings, the axial and radial displacements of the shaft can be effectively reduced, and the stability of the rotational motion can be improved. In addition, the two bearings jointly bear the load on the shaft, reducing the force on a single bearing, thereby improving the load-bearing capacity and durability of the overall structure.

[0073] According to one embodiment of the present application, further, the control unit is electrically connected to the sensor assembly (the third sensor 536, the fourth sensor 537) and the second drive assembly 533 respectively, the sensor assembly is used to send the monitoring signal to the control unit, and the control unit sends the control signal to the second drive assembly 533 to drive the positioning assembly 532 to rotate and swing back and forth.

[0074] like Figure 2-Figure 3As shown, the chemiluminescent immunoassay analyzer includes a frame body 110 and a tube library 120, a diluent compartment 130, a sample arm 140, a tube library gripper 150, an incubation unit 160, a cleaning gripper 170, a reagent arm 180, an incubation gripper 190, a cleaning unit 210, a reagent compartment 220, a detection unit 230, a detection gripper 240, a liquid circuit unit and a control unit (not shown) arranged thereon. The tube reservoir, the cleaning unit and the reagent reservoir are arranged in sequence along the counterclockwise rotation direction of the incubation unit, and the cleaning unit is located between the detection unit and the incubation unit; the diluent reservoir is arranged to be located on the same side of the incubation unit as the tube reservoir; wherein the diluent reservoir comprises a reservoir body, and a plurality of spaced grooves may be arranged on the reservoir body, in which a first container 3a (3b, 3c) containing a diluent and a second container 3d containing a first cleaning liquid are placed; the reservoir body is configured to be able to move horizontally along a first direction; when the reservoir body is located at the operating position, the diluent is added to the first container and / or the first cleaning liquid is added to the second container; when the reservoir body is located at the working position, the sample injection needle on the sample arm of the host absorbs the diluent in the first container or the sample injection needle on the sample arm of the host absorbs the first cleaning liquid in the second container for cleaning. Specifically, a second guide block may be provided at the bottom of the bin body, a second base frame may be installed on the bottom plate of the rack body 110, a second slide rail may be provided on the second base frame, the second slide rail extends along the first direction, and the second guide block is adapted to the second slide rail so that the bin body moves horizontally forward and backward along the first direction. The diluent bin may also include a second drive device, which is used to drive the bin body to move horizontally forward and backward along the second slide rail. The second drive device may be, for example, a transmission device such as a motor-driven synchronous belt or chain, which is not limited here. In this way, the bin body can move forward and backward driven by the motor. When working, the bin body is conveyed to the rear working position of the instrument. When the consumables are exhausted and need to be replaced, the bin body is conveyed to the front operating position of the instrument, which is convenient for the operator to replace the diluent bottle and the first cleaning liquid bottle. For example, an indicator light may be provided in the bin body and a sensor may be provided in the diluent bottle. The initial liquid volume in the bottle is fixed. Whether the consumables are exhausted can be known by quantitative absorption calculation, and the sensor may also be used to detect whether the consumables in the bottle have been exhausted. When the consumables are used up and need to be replaced, the bin is transferred to the front operating position of the instrument, and the indicator light in the corresponding groove position flashes to indicate that the corresponding diluent bottle needs to be replaced. In addition, the first cleaning liquid bottle is arranged at the corresponding position of the bin body of the diluent bin, which can save costs and avoid the complexity of the structure and the increase in cost caused by the use of corresponding pipelines and pumping systems when the first cleaning liquid barrel is arranged below the frame body 110.

[0075] The tube warehouse 120 is used for loading and automatically arranging reaction tubes and arranging them in sequence on the cup arrangement plate; the diluent warehouse 130 is used for loading diluent and the first cleaning liquid, the diluent is used to dilute the sample, and the first cleaning liquid is used to clean the sample needle; the sample arm 140 is used to transport the sample and the diluent; the tube warehouse gripper 150, the cleaning gripper 170, the incubation gripper 190, and the detection gripper 240 are all used for transporting the reaction tubes; the incubation unit 160 is used to incubate the reaction tubes containing the sample and reagent conjugate at a constant temperature of 37°C; the reagent arm 180 is used to transport the reagents in the test kit; the cleaning unit 210 is used to clean the conjugate in the reaction tube and remove interfering substances; the reagent warehouse 220 is used to load the test kit and keep it refrigerated at 2-8°C; the detection unit 230 is used to measure the light value of the conjugate in the reaction tube and discharge the waste liquid in the reaction tube that has completed the detection. Figure 1 and Figure 2 The dotted lines in are paths drawn with the robot arms as the rotation radius when the robot arms of the sample arm 140 , the reagent arm 180 and the tube library gripper 150 rotate.

[0076] The incubation unit 160 is used to provide a constant temperature for the samples and reactants in the reaction tubes; the incubation unit 160 may be provided with a plurality of holes for carrying the reaction tubes, and the incubation unit 160 may include a heating ring 162 and a processing ring 161 arranged sequentially from the inside to the outside, the tube placement position 6i, the sample addition position 6j and the reagent addition position 6k are arranged on the processing ring 161, and the tube placement positions 6a, 6b, 6c and the tube removal positions 6d, 6e, 6f are arranged on the heating ring 162. The processing ring 161 and the heating ring 162 are both configured to rotate clockwise or counterclockwise independently. The tube warehouse 120 includes a cup arrangement tray 101, and the tube warehouse 120 can automatically arrange disordered reaction tubes on the cup arrangement tray 101. The reaction tubes on the tube warehouse 120 can be transferred in the incubation unit 160, the cleaning unit 210 and the detection unit 230 to carry samples and reagents. The tube storage gripper 150 is disposed between the incubation unit 160 and the tube storage 120, and can grab the reaction tube from the tube grabbing position on the cup arrangement plate 101 and transport it to the incubation unit 160. The cleaning unit 210 can be disposed between the detection unit 230 and the incubation unit 160. The cleaning unit 210 is disposed at a position corresponding to the tube taking positions 6d, 6e, and 6f, and is used to clean the combination of the sample and the reagent in the reaction tube, remove impurities and interfering substances, and improve the detection accuracy.

[0077] The reagent bin 220 is disposed at a position corresponding to the reagent adding position 6k, and is used to load a reagent box containing reagents; when the processing ring 161 rotates counterclockwise, the reagent bin 220 may be located downstream of the cleaning unit 210. The reagent bin 220 may include a housing, and a cooling branch is connected to the housing so that a coolant is passed into the housing of the reagent bin for cooling, and the reagent box may be kept in a refrigerated environment of 2-8°C. The reagent arm 180 is disposed between the reagent bin 220 and the incubation unit 160, and is used to transport the reagent in the reagent bin 220 to the reaction tube on the reagent position.

[0078] The liquid circuit unit may include a waste liquid barrel, a trash can, a system liquid barrel, a cleaning liquid barrel, an excitation liquid barrel, etc., which are arranged below the rack body 110. The waste liquid barrel is used to recycle waste liquid generated by the luminescent immunoassay analyzer; the trash can is used to store reaction tubes discarded through the waste channel 1402. For easy replacement and cleaning, the waste liquid barrel and the trash can can be pulled out through a drawer structure.

[0079] The specific workflow of the one-step method of the host is as follows:

[0080] Without dilution function: the tube library gripper 150 grabs the reaction tube from the tube grabbing position 1a on the cup tray 101 and moves it to the tube placing position 6i on the processing ring 161. The processing ring 161 rotates counterclockwise and transports the reaction tube to the sample adding position 6j. The lifting and dispatching trolley pulls out the corresponding sample rack on the sample library buffer area and transfers it to the sampling position 2a on the first track. The sample arm 140 absorbs the sample on the first track and injects it into the reaction tube on the processing ring 161. The processing ring 161 continues to rotate counterclockwise and transports the reaction tube to the reagent adding position 6k. The reagent arm 180 absorbs the reagent in the corresponding project reagent kit of the reagent chamber 220 and injects it into the reaction tube on the processing ring 161. The processing ring 161 continues to rotate counterclockwise and transports the reaction tube to the mixing position 6m for mixing the sample and the reagent. The processing ring 161 continues to rotate counterclockwise and transports the reaction tube to the mixing position 6m. The reaction tube is sent to the first operating position 6g, and the incubation gripper 190 moves the reaction tube to the tube placement position 6a (6b, 6c) on the heating ring 162. After a certain period of constant temperature incubation reaction, the cleaning gripper 170 moves the reaction tube from the tube removal position 6d (6e, 6f) on the heating ring 162 to the tube entry position 10a on the cleaning unit 210. The cleaning unit 210 rotates counterclockwise and cleans the reaction complex in the reaction tube. The detection gripper 240 moves the reaction tube from the tube outlet position 10b on the cleaning unit 210 to the tube entry position 12a on the detection unit 230. The detection unit 230 rotates clockwise to sequentially pass the reaction tube through the excitation liquid filling, the photon counting detection unit and the solid-liquid separation. Finally, the reaction tube that has been tested is thrown into the discarding channel 1402 from the tube entry position 12a on the detection unit 230 by the detection gripper 240. The sample rack that has completed the sampling action on the first track is transferred to the reversing trolley, which moves backward to transfer the sample rack to the second track, and is finally transferred to the recovery area of ​​the sample library through the lifting and scheduling trolley.

[0081] With dilution function: the tube library gripper 150 grabs the reaction tube from the tube grabbing position 1a on the cup arrangement tray 101 and moves it to the dilution and mixing position 1403. The lifting and dispatching trolley pulls out the corresponding sample rack on the sample library buffer area and transfers it to the sampling position 2a on the first track. The sample arm 140 absorbs the sample on the first track and adds it to the reaction tube on the dilution and mixing position 1403. Then, the sample arm 140 absorbs the diluent from the liquid taking port of the first container 3a (3b, 3c) on the diluent bin 130 and adds it to the reaction tube on the dilution and mixing position 1403. The dilution and mixing position 1403 mixes the sample and the diluent in the reaction tube. 0 Grab the reaction tube from the tube grabbing position 1a on the cup tray 101 and move it to the tube placing position 6i on the processing ring 161. The processing ring 161 rotates counterclockwise and transports the reaction tube to the sample adding position 6j. The sample arm 140 absorbs the diluted sample and adds it to the reaction tube on the processing ring 161. The tube library gripper 150 discards the reaction tube on the dilution and mixing position 1403 into the tube discarding channel 1402. The processing ring 161 continues to rotate counterclockwise and transports the reaction tube to the reagent adding position 6k. The subsequent process (reagent filling, constant temperature incubation, cleaning, testing and transporting the reaction tube back to the sample library, etc.) is the same as the workflow without the dilution function and will not be repeated here.

[0082] The specific workflow of the host's two-step or multi-step method is as follows:

[0083] The difference between the two-step method and the one-step method is that the one-step method only requires one constant temperature incubation and one washing, while the two-step method requires two rounds of constant temperature incubation and washing. In view of the special requirements of the reaction system, the layout of this application can flexibly meet different requirements by controlling the timing.

[0084] The details are as follows: it is only necessary to control the storage intervals of the reaction tubes on the processing ring 161 and the cleaning unit 210. When the reaction tube that has completed the first round of cleaning is transferred to the tube entry position 10a of the cleaning unit 210, the cleaning gripper 170 grabs it and places it in the empty space on the processing ring 161 for 6 hours. The subsequent process actions are the same as the one-step method, and the second round of reagent filling, constant temperature incubation and cleaning is carried out.

[0085] The second aspect of the present invention provides a sample detection method, using the above-mentioned chemiluminescent immunoassay analyzer to detect the sample, such as Fig.17 As shown, the following specific steps may be included:

[0086] S110, placing a sample rack containing samples to be tested into a loading area of ​​a sample library;

[0087] S120, transferring the sample rack containing the samples to be tested from the loading area to the buffer area via the lifting and dispatching trolley, and identifying and recording the information of each sample to be tested;

[0088] S130, determining whether the sample to be tested is to be inspected by the first host; if so, transferring the sample rack containing the sample to be tested from the buffer area to the first track of the first host via the lifting and dispatching trolley, and conveying it to the preset position of the first host via the first track, so as to be sampled by the sample arm of the first host; if not, transferring the sample rack containing the sample to be tested from the buffer area to the third track via the lifting and dispatching trolley, so as to be quickly conveyed to the corresponding position, and switching it to the first track of the second host via the reversing trolley, and conveying it to the preset position of the second host via the first track, so as to be sampled by the sample arm of the second host;

[0089] S140, the sample rack that has completed the test is switched to the second track via the reversing trolley, and is transported to the recovery area of ​​the sample library via the second track and the lifting and scheduling trolley. Specifically, the sample rack containing the sample to be tested can be manually placed in the loading area of ​​the sample library, and the buffer area can be set below the loading area. The lifting and scheduling trolley descends to transfer the sample rack containing the sample to be tested to the buffer area, and the information of each sample to be tested is identified and recorded; in this way, the buffer area can store multiple sample racks. The chemiluminescent immunoassay analyzer provided in the embodiment of the utility model may include multiple hosts, and the detection tasks are dispatched and allocated according to the sample information of the uploaded buffer area and the status of each host, that is, different hosts can perform different detection tasks, so different sample racks containing samples to be tested need to be dispatched to the preset positions of different hosts for sampling by the sample arm of the host; in this way, the samples to be tested can be dispatched and transported to multiple hosts for detection through the lifting and scheduling trolley and the track conveying mechanism, so as to realize continuous testing of large quantities of samples, which can improve the speed and efficiency of the test. For the samples that have been tested, they can be transported to the recovery area of ​​the sample library after transportation, which is convenient for recycling and processing.

[0090] For abnormal shutdown, the process of equipment self-check before restarting is as follows:

[0091] 1) The process of handling abnormal shutdown of the host is as follows:

[0092] In case of abnormal shutdown, the instrument can automatically detect and clean the reaction tubes remaining on each module of the host during the power-on self-test.

[0093] The details are as follows: the processing ring 161 rotates hole by hole, and detects whether there are any residual reaction tubes through the sensor at the tube placement position 6i, and throws the remaining reaction tubes into the discard tube channel 1402 through the tube warehouse gripper 150. When all the residual reaction tubes on the processing ring 161 are cleaned, the heating ring 162 rotates hole by hole, and detects whether there are any residual reaction tubes through the sensor at the tube placement position 6a (6b, 6c), and the remaining reaction tubes are grabbed and placed on the processing ring 161 through the incubation gripper 190, and the remaining reaction tubes are passed to the tube warehouse gripper 150 through the processing ring 161 and thrown into the discard tube channel 1402.

[0094] At the same time, the cleaning unit 210 rotates one hole position at a time, and uses a sensor to detect whether there are any residual reaction tubes at the tube outlet position 10b, and uses the detection gripper 240 to drop the remaining reaction tubes into the discard tube channel 1402. After that, each time the detection unit 230 rotates one hole position, the detection gripper 240 performs a grabbing action, and if there are any residual reaction tubes, they are dropped into the discard tube channel 1402.

[0095] 2) The process of handling abnormal shutdown of the sample library and track conveying mechanism is as follows:

[0096] In case of abnormal shutdown, the instrument can automatically detect and clean the sample racks remaining in the lifting and dispatching trolley, track conveying mechanism, and buffer area during the power-on self-test.

[0097] The details are as follows: first, determine whether there is a sample rack on the lifting and dispatching trolley; if so, transfer the sample rack to the recovery area of ​​the sample library; secondly, determine whether there is a sample rack on the track conveying mechanism; if so, transfer the sample rack to the recovery area of ​​the sample library via the second track and the lifting and dispatching trolley; finally, determine whether there is a sample rack in the buffer area; if so, transfer the sample rack in the buffer area to the recovery area of ​​the sample library via the lifting and dispatching trolley.

[0098] It should be understood that the above specific embodiments of the present invention are only used to illustrate or explain the principles of the present invention, and do not constitute a limitation on the present invention. Therefore, any modifications, equivalent substitutions, improvements, etc. made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. In addition, the claims attached to the present invention are intended to cover all changes and modifications that fall within the scope and boundaries of the attached claims, or the equivalent forms of such scope and boundaries.

Claims

1. A chemiluminescent immunoassay analyzer, characterized in that: include: At least one host, the host is used to detect the sample to be tested; A sample library is arranged at one side of the host, and the sample library is arranged to extend along a first direction; the sample library comprises a library rack, the library rack is provided with a loading area, a recovery area and a buffer area, the loading area, the recovery area and the buffer area can store a plurality of sample racks, the sample racks are arranged to be arranged side by side along the first direction, a plurality of sample tubes are mounted on the sample rack, and the sample rack is configured to be able to move horizontally on the library rack along the first direction; the loading area and the recovery area are arranged to be arranged side by side along the first direction, and the buffer area is arranged below the loading area and the recovery area; the sample library is used for loading, identifying information, caching and recovering samples to be tested; A track conveying mechanism is arranged on the other side of the mainframe, and the track conveying mechanism is arranged to extend along the second direction; the track conveying mechanism comprises a first track and a second track which are arranged side by side and horizontally from near to far from the mainframe; wherein the first track is used to convey the sample rack containing the sample to be tested in the sample library to a preset position for sampling by the sample arm of the mainframe; the second track is used to convey the sample rack that has completed the test to the recovery area of ​​the sample library; wherein, The first direction and the second direction are perpendicular to each other.

2. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The host comprises a plurality of hosts, each of which is arranged side by side along the second direction; The track conveying mechanism is independently arranged on one side of each main machine.

3. The chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The track conveying mechanism also includes: A third track, located between the first track and the second track, is used to quickly transport the sample rack containing the samples to be tested in the sample library to a preset position corresponding to the next host; A reversing trolley located at one end of the track conveying mechanism away from the sample library, the reversing trolley being configured to be movable along a first direction to transfer the sample rack on the first track to the second track; or The reversing trolley is used to transfer the sample rack containing the samples to be tested in the sample library to the first track of the current host via the third track of the previous host, and the sample rack is transported to the preset position of the current host via the first track for sampling by the sample arm of the current host; or The reversing trolley is used to transfer the sample rack containing the samples to be tested in the sample library via the third track of the previous host to the third track of the current host, so as to be transported to the first track of the next host.

4. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The sample library also includes: A lifting and dispatching trolley is arranged in the library rack, the lifting and dispatching trolley is located between the main machine and the loading area, and the lifting and dispatching trolley is configured to be able to move horizontally along the first direction and vertically along the third direction to transfer the sample rack stored in the loading area to the buffer area, and to realize the transfer of the sample rack between the track conveying mechanism and the sample library; wherein, The third direction is perpendicular to the first direction.

5. The chemiluminescent immunoassay analyzer according to claim 4, characterized in that: The lifting and dispatching trolley comprises: A first base frame body; The first moving mechanism includes a first guide rail and a first slider, the first slider is connected and fixed to the bottom of the first base body, the first guide rail is arranged to extend along a first direction, the first guide rail is installed on the bottom plate of the library frame, and the first slider is adapted to the first guide rail so that the first base body moves horizontally along the first direction; A lifting frame, the top of which is provided with a scheduling track for the sample rack to pass through or buffer; The second moving mechanism includes a second guide rail and a second slider. The second guide rail extends along the third direction and is installed on the vertical plate of the first base body. The second slider is connected and fixed to the bottom of the lifting frame. The first slider is adapted to the first guide rail to enable the lifting frame to move vertically along the third direction.

6. The chemiluminescent immunoassay analyzer according to claim 5, characterized in that: The lifting and dispatching trolley also includes: A hook lifting mechanism, comprising a second base frame body and a hook assembly disposed on the second base frame body; wherein the hook assembly is configured to be able to move up and down along the second base frame body; The third moving mechanism includes a third guide rail and a third slider; the third guide rail extends along the second direction and is mounted on the bottom plate of the lifting frame; the third slider is mounted on the bottom of the second base body and is matched with the third guide rail to enable the second base body to move laterally along the second direction; wherein, When the hook assembly rises to the working position, the hook assembly is connected to the sample rack in the scheduling track at the top of the lifting frame, so that when the second base frame body moves laterally along the second direction, the hook assembly drives the sample rack in the scheduling track to move laterally; When the hook assembly descends to its original position, the hook assembly is separated from the sample rack in the scheduling track.

7. The chemiluminescent immunoassay analyzer according to claim 6, characterized in that: The hook lifting mechanism also includes: A driving assembly, mounted on the second base body; The cam assembly comprises a cam arm and a pulley arranged on the cam arm, wherein the pulley is configured to be able to rotate around an axis; the cam arm is mounted on the driving assembly, and the driving assembly drives the cam arm to reciprocate and rotate within a preset angle; wherein, The outer peripheral surface of the pulley is pressed against the bottom of the hook assembly, so that the hook assembly can move up and down along the second base frame body when the cam arm reciprocates and swings; the rotation axis of the pulley and the rotation axis of the driving assembly are set to a predetermined distance.

8. The chemiluminescent immunoassay analyzer according to claim 5, characterized in that: The lifting and dispatching trolley also includes: A positioning mechanism is arranged at the top of the lifting frame, and is used to block the sample rack transported by the second track from entering the scheduling track at the top of the lifting frame, so as to achieve positioning of the sample rack in the scheduling track; the positioning mechanism includes: A positioning assembly, comprising a positioning member, wherein the positioning member is configured to be capable of reciprocating rotation and swinging; When the positioning member rotates to the blocking position, the positioning member contacts the sample rack in the scheduling track to prevent the sample rack from passing through the scheduling track; when the positioning member rotates to the original position, the positioning member moves away from the scheduling track to allow the sample rack to pass through the scheduling track.

9. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The shelf is provided with a partition to separate the top layer of the shelf into a loading area and a recycling area; The top layer of the library rack is provided with an emergency track for accommodating and transporting emergency sample racks, and the emergency track is arranged on the other side of the loading area away from the recovery area; An anti-misplacement mechanism is provided in the emergency track to detect whether the emergency sample rack is correctly placed.

10. The chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The host comprises: The rack body and the tube warehouse, diluent tank, incubation unit, cleaning unit, reagent tank and detection unit arranged on the rack body; the tube warehouse, cleaning unit and reagent tank are arranged in sequence along the counterclockwise direction of the incubation unit, and the cleaning unit is located between the detection unit and the incubation unit; the diluent tank is arranged to be located on the same side of the incubation unit as the tube warehouse; wherein, The diluent bin comprises a bin body, on which a plurality of spaced grooves may be arranged, in which a first container containing a diluent and a second container containing a first cleaning liquid are placed; the bin body is configured to be able to move horizontally along a first direction; when the bin body is located in an operating position, the diluent can be added to the first container and / or the first cleaning liquid can be added to the second container; when the bin body is located in a working position, the sample injection needle on the sample arm of the host can absorb the diluent in the first container or the sample injection needle on the sample arm of the host can absorb the first cleaning liquid in the second container for cleaning.

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