Immunomagnetic Separation Demonstration Device

Abstract

The present application is applicable to the technical field of demonstration equipment, and provides an immunomagnetic separation demonstration device. It includes: a transparent container; a fixed model, installed in the transparent container; a composite component, the composite component includes a composite part, the composite part includes: a first model, located in the transparent container, the first model can move in the transparent container; a second model, located in the transparent container, the second model can move in the transparent container; wherein the composite part has a combined state and a separated state, when the composite part is in the combined state, the first model and the second model are connected, and the composite part blocks the fixed model; when the composite part is in the separated state, the first model and the second model are separated, and the composite part moves relative to the fixed model to expose the fixed model. The immunomagnetic separation demonstration device of the present application can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology, which is conducive to the viewer's understanding and mastering of the principle of the immunomagnetic separation technology, and is also conducive to the promotion of the immunomagnetic separation technology.

Description

Technical Field

[0001] The present application belongs to the technical field of demonstration equipment, and more specifically, to an immunomagnetic separation demonstration device. Background Art

[0002] Immunomagnetic separation technology (IMS) is a biological separation technology that uses magnetic particles or nanoparticles as magnetic carriers to separate target molecules (such as cells, pathogens, proteins, etc.) from samples through the specific binding of antigens and antibodies.

[0003] In the related art, when using immunomagnetic separation technology to separate target molecules from a sample, first, specific antibodies are coupled to the surface of a magnetic carrier to form an antibody-magnetic carrier complex, and then the sample containing the target molecules is mixed with the antibody-magnetic carrier complex to allow the target molecules to combine with the antibody-magnetic carrier complex to form a target-antibody-magnetic carrier complex, thereby separating the target molecules from other substances in the sample, and finally separating the target molecules from the antibody-magnetic carrier complex.

[0004] Although immunomagnetic separation technology has advantages, there is no demonstration device in the related art that can intuitively and three-dimensionally demonstrate the separation process of immunomagnetic separation technology to show the advantages of immunomagnetic separation technology. Utility Model Content

[0005] The purpose of the embodiments of the present application is to provide an immunomagnetic separation demonstration device, aiming to solve the technical problem in the related art that there is no demonstration device that can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology.

[0006] To achieve the above-mentioned purpose, according to one aspect of the present application, an immunomagnetic separation demonstration device is provided, comprising: a transparent container; a fixed model installed in the transparent container; a composite component, the composite component comprising a composite part, the composite part comprising: a first model located in the transparent container, the first model being able to move in the transparent container; a second model located in the transparent container, the second model being able to move in the transparent container; wherein the composite part has a combined state and a separated state, when the composite part is in the combined state, the first model and the second model are connected, and the composite part covers the fixed model; when the composite part is in the separated state, the first model and the second model are separated, and the composite part moves relative to the fixed model to expose the fixed model.

[0007] Optionally, the composite component further includes: a first traction member, located outside the transparent container, capable of driving the first model to move in the transparent container; and a second traction member, located outside the transparent container, capable of driving the second model to move in the transparent container.

[0008] Optionally, the first model is a magnetic fluid, the first traction part is a magnetic part, and the first model is connected to the first traction part by magnetic attraction; the second model is a magnetic fluid, the second traction part is a magnetic part, and the second model is connected to the second traction part by magnetic attraction; the fixed model is a flat sticker, and the fixed model is fixedly attached to the inner wall of the transparent container.

[0009] Optionally, the immunomagnetic separation demonstration device also includes a mounting seat, which is provided with a mounting groove, and the transparent container is installed in the mounting groove; the first traction member can slide on the groove wall of the mounting groove, and the second traction member can slide on the groove wall of the mounting groove.

[0010] Optionally, the immunomagnetic separation demonstration device also includes a transmission assembly, the transmission assembly includes a first transmission rack and a second transmission rack, the first traction member is installed on the first transmission rack, and the first transmission rack can slide on the groove wall of the mounting groove; the second traction member is installed on the second transmission rack, and the second transmission rack can slide on the groove wall of the mounting groove in a direction approaching or away from the first transmission rack; the immunomagnetic separation demonstration device also includes a driving assembly, the driving assembly includes a first driving member and a second driving member, the output shaft of the first driving member is drivingly connected to the first transmission rack to drive the first transmission rack to slide; the output shaft of the second driving member is drivingly connected to the second transmission rack to drive the second transmission rack to slide.

[0011] Optionally, a receiving groove is provided on the mounting seat, and the driving assembly is installed in the receiving groove; a plurality of connecting ports connected to the mounting groove are provided on the groove wall of the receiving groove, the output shaft of the first driving member corresponds to one connecting port, and is meshed with the first transmission rack through the corresponding connecting port; the output shaft of the second driving member corresponds to another connecting port, and is meshed with the second transmission rack through the corresponding connecting port.

[0012] Optionally, the transmission assembly also includes a first slide rail and a second slide rail, the first slide rail is installed on the groove wall of the mounting groove, and the first transmission rack is slidably installed on the first slide rail; the second slide rail is installed on the groove wall of the mounting groove, and the second transmission rack is slidably installed on the second slide rail.

[0013] Optionally, the first transmission rack slides on the groove wall of the installation groove along the circumference of the transparent container, and the second transmission rack slides on the groove wall of the installation groove along the circumference of the transparent container.

[0014] Optionally, the first transmission rack and the second transmission rack are arranged at intervals along the length direction of the transparent container.

[0015] Optionally, the number of composite components is multiple groups, and the composite components are arranged at intervals along the length direction of the transparent container; the number of transmission components is the same as the number of composite components, and multiple groups of transmission components are arranged in a one-to-one correspondence with multiple groups of composite components; the number of drive components is the same as the number of transmission components, and multiple groups of drive components are arranged in a one-to-one correspondence with multiple groups of transmission components.

[0016] The beneficial effect of the immunomagnetic separation demonstration device provided by the present application is that: compared with the prior art, when the immunomagnetic separation demonstration device of the present application is demonstrated, the composite part is first placed in a separated state so that the first model and the second model are separated and the fixed model can be observed. At this time, the fixed model is equivalent to a sample with target molecules, the first model is equivalent to a magnetic carrier, and the second model is equivalent to a specific antibody; then the composite part is switched from the separated state to the combined state so that the first model and the second model are connected, and the fixed model is shielded by the composite part. At this time, the combination of the first model, the second model and the fixed model is equivalent to a target-antibody-magnetic carrier complex; then the composite part is switched from the combined state to the separated state again so that the first model and the second model are separated again and the fixed model can be observed again. At this time, the fixed model is equivalent to other substances in the sample, the first model is equivalent to an antibody-magnetic carrier complex, and the second model is equivalent to a target molecule; the immunomagnetic separation demonstration device of the present application can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology, which is not only conducive to the viewer's understanding and mastering of the principle of the immunomagnetic separation technology, but also conducive to the promotion of the immunomagnetic separation technology; in addition, the transparent container provided is convenient for the observer to observe the situation inside the transparent container. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0018] Figure 1 A schematic diagram of the structure of the immunomagnetic separation demonstration device provided in an embodiment of the present application;

[0019] Figure 2 A schematic top view of the assembled transparent container, fixed model and composite component provided in an embodiment of the present application;

[0020] Figure 3 A schematic front view of the transparent container, the fixed model and the composite component after being assembled according to the embodiment of the present application;

[0021] Figure 4A cross-sectional schematic diagram of the assembled mounting base, the first slide rail, and the second slide rail provided in an embodiment of the present application;

[0022] Figure 5 A front cross-sectional schematic diagram of the mounting base and the transmission assembly after being assembled according to an embodiment of the present application;

[0023] Figure 6 A front view schematic diagram of a first transmission rack provided in an embodiment of the present application;

[0024] Figure 7 A cross-sectional schematic diagram of the assembled mounting base and transmission assembly provided in an embodiment of the present application;

[0025] The reference numerals in the above drawings are as follows:

[0026] 100, transparent container; 200, fixed model; 300, composite component; 310, composite part; 311, first model; 312, second model; 320, first traction member; 330, second traction member;

[0027] 400, mounting seat; 410, mounting groove; 420, receiving groove; 430, spacer;

[0028] 510, first transmission rack; 520, second transmission rack; 530, first slide rail; 540, second slide rail. DETAILED DESCRIPTION

[0029] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0030] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or indirectly connected to the other element. In the absence of conflict, the embodiments in this application and the features in the embodiments may be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0031] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0032] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features. In the description of this application, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0033] As described in the background technology, at present, immunomagnetic separation technology (English full name: Immunomagnetic Separation, English abbreviation: IMS) is a biological separation technology that uses magnetic particles or nanoparticles as magnetic carriers to separate target molecules (such as cells, pathogens, proteins and other substances) from samples through the specific binding of antigens and antibodies. In the related art, when using immunomagnetic separation technology to separate target molecules from samples, first, the surface of the magnetic carrier is coupled with specific antibodies to form an antibody-magnetic carrier complex, and then the sample containing the target molecule is mixed with the antibody-magnetic carrier complex, so that the target molecule is combined with the antibody-magnetic carrier complex to form a target-antibody-magnetic carrier complex, so that the target molecule is separated from other substances in the sample, and finally the target molecule is separated from the antibody-magnetic carrier complex. Although the immunomagnetic separation technology has advantages, there is no demonstration device in the related art that can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology to show the advantages of the immunomagnetic separation technology.

[0034] Reference Figures 1 to 3In order to solve the above problems, according to one aspect of the present application, an embodiment of the present application provides an immunomagnetic separation demonstration device, which includes a transparent container 100, a fixed model 200 and a composite component 300, wherein the fixed model 200 is installed in the transparent container 100; the composite component 300 includes a composite part 310, and the composite part 310 includes a first model 311 and a second model 312, the first model 311 is located in the transparent container 100, and the first model 311 can move in the transparent container 100; the second model 312 is located in the transparent container 100, and the second model 312 can move in the transparent container 100; wherein the composite part 310 has a combined state and a separated state, when the composite part 310 is in the combined state, the first model 311 and the second model 312 are connected, and the composite part 310 blocks the fixed model 200; when the composite part 310 is in the separated state, the first model 311 and the second model 312 are separated, and the composite part 310 moves relative to the fixed model 200 to expose the fixed model 200.

[0035] In the embodiment of the present application, the transparent container 100 is generally made of acrylic material or transparent glass material; the fixed model 200 is generally fixedly installed in the transparent container 100; the first model 311 and the second model 312 are generally connected and separated by magnetic attraction, so that the composite part 310 can switch between the combined state and the separated state; in other embodiments, the first model 311 and the second model 312 can also be connected and separated by buckles or buckles. Figure 1 The composite part 310 is in a combined state to cover the fixed model 200; Figure 2 The composite part 310 is in a separated state so that the fixed model 200 is exposed; Figure 3 The composite part 310 in the figure is in a combined state to shield the fixed model 200.

[0036] When the immunomagnetic separation demonstration device of the present application is demonstrated, the composite part 310 is first placed in a separated state to separate the first model 311 and the second model 312, and the fixed model 200 can be observed. At this time, the fixed model 200 is equivalent to a sample with target molecules, the first model 311 is equivalent to a magnetic carrier, and the second model 312 is equivalent to a specific antibody; then the composite part 310 is switched from the separated state to the combined state, so that the first model 311 and the second model 312 are connected, and the fixed model 200 is shielded by the composite part 310. At this time, the combination of the first model 311, the second model 312 and the fixed model 200 is equivalent to the target-antibody-magnetic carrier composite. compound; then the composite part 310 is switched from the combined state to the separated state again, so that the first model 311 and the second model 312 are separated again, and the fixed model 200 can be observed again. At this time, the fixed model 200 is equivalent to other substances in the sample, the first model 311 is equivalent to the antibody-magnetic carrier complex, and the second model 312 is equivalent to the target molecule; the immunomagnetic separation demonstration device of the present application can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology, which is not only conducive to the viewer's understanding and mastering of the principle of the immunomagnetic separation technology, but also conducive to the promotion of the immunomagnetic separation technology; in addition, the set transparent container 100 is convenient for the observer to observe the situation inside the transparent container 100.

[0037] Reference Figure 2 and Figure 3 In one embodiment, the composite component 300 further includes a first traction member 320 and a second traction member 330, wherein the first traction member 320 is located outside the transparent container 100, and the first traction member 320 can drive the first model 311 to move in the transparent container 100; the second traction member 330 is located outside the transparent container 100, and the second traction member 330 can drive the second model 312 to move in the transparent container 100.

[0038] In this embodiment, the first traction member 320 is generally a magnet, in which case the first model 311 is a magnetic component; the second traction member 330 is generally a magnet, in which case the second model 312 is a magnetic component; in other embodiments, the first traction member 320 may also be an electromagnet, in which case the first model 311 is a magnetic component, the second traction member 330 may also be an electromagnet, and the second model 312 is a magnetic component. The first traction member 320 plays a traction role, which is convenient for driving the first model 311 to move smoothly in the transparent container 100; the second traction member 330 plays a traction role, which is convenient for driving the second model 312 to move smoothly in the transparent container 100. In addition, in order to reduce manufacturing costs, the first traction member 320 and the second traction member 330 have the same structure.

[0039] Reference Figure 2 and Figure 3 In one embodiment, the first model 311 is a magnetic fluid, the first traction member 320 is a magnetic member, and the first model 311 and the first traction member 320 are connected by magnetic attraction; the second model 312 is a magnetic fluid, the second traction member 330 is a magnetic member, and the second model 312 and the second traction member 330 are connected by magnetic attraction.

[0040] In this embodiment, the first traction member 320 is generally a magnet or a magnetic block, and the second traction member 330 is generally a magnet or a magnetic block. Since the first model 311 and the second model 312 are both magnetic fluids, when the composite part 310 is in the combined state, the first model 311 and the second model 312 are fused together; when the composite part 310 is in the separated state, the second model 312 is located on one side of the first model 311.

[0041] Since magnetic fluid has good fluidity and deformability, the design that the first model 311 and the second model 312 are both magnetic fluid is conducive to connecting and separating the first model 311 and the second model 312, thereby facilitating the switching of the composite part 310 between the combined state and the separated state.

[0042] Reference Figure 2 and Figure 3 In one embodiment, the fixed model 200 is a flat sticker, and the fixed model 200 is fixedly attached to the inner wall of the transparent container 100 .

[0043] In this embodiment, the fixed model 200 is generally a colored flat sticker, and the fixed model 200 is fixedly attached to the inner wall of the transparent container 100 by gluing, and the first model 311 and the second model 312 are both moved above the fixed model 200 to smoothly shield the fixed model 200. The design of the fixed model 200 as a flat sticker not only effectively reduces the manufacturing cost of the immunomagnetic separation demonstration device while ensuring the demonstration effect, but also ensures the shielding effect of the composite part 310 on the fixed model 200.

[0044] Reference Figure 1 and Figure 4 In one embodiment, the immunomagnetic separation demonstration device also includes a mounting seat 400, which is provided with a mounting groove 410, and the transparent container 100 is installed in the mounting groove 410; the first traction member 320 can slide on the groove wall of the mounting groove 410, and the second traction member 330 can slide on the groove wall of the mounting groove 410.

[0045] In this embodiment, usually part of the structure of the transparent container 100 is installed in the installation groove 410; when the immunomagnetic separation demonstration device of the present application is demonstrated, the first traction member 320 and the second traction member 330 both slide on the groove wall of the installation groove 410 to connect or separate the first model 311 and the second model 312, so that the composite part 310 switches between the combined state and the separated state. The provided mounting seat 400 plays the role of supporting and carrying the transparent container 100. The provided installation groove 410 not only plays the role of protecting the transparent container 100, but also plays the role of reducing the volume of the immunomagnetic separation demonstration device.

[0046] Reference Figures 4 to 7 In one embodiment, the immunomagnetic separation demonstration device also includes a transmission assembly, the transmission assembly includes a first transmission rack 510 and a second transmission rack 520, the first traction member 320 is installed on the first transmission rack 510, and the first transmission rack 510 can slide on the groove wall of the mounting groove 410; the second traction member 330 is installed on the second transmission rack 520, and the second transmission rack 520 can slide on the groove wall of the mounting groove 410 in a direction approaching or away from the first transmission rack 510; the immunomagnetic separation demonstration device also includes a driving assembly, the driving assembly includes a first driving member and a second driving member, the output shaft of the first driving member is drivingly connected to the first transmission rack 510 to drive the first transmission rack 510 to slide; the output shaft of the second driving member is drivingly connected to the second transmission rack 520 to drive the second transmission rack 520 to slide.

[0047] In this embodiment, the first traction member 320 is fixedly installed on the first transmission rack 510 by welding or bolts, and the second traction member 330 is fixedly installed on the second transmission rack 520 by welding or bolts; the first driving member is generally a reduction motor or a driving motor, and the output shaft of the first driving member is generally engaged with the first transmission rack 510 to drive the first transmission rack 510 to slide on the groove wall of the installation groove 410; the second driving member is generally a reduction motor or a driving motor, and the output shaft of the second driving member is generally engaged with the second transmission rack 520 to drive the second transmission rack 520 to slide on the groove wall of the installation groove 410. By using the first transmission rack 510 and the first driving member in the present application to drive the first traction member 320 to move, it is beneficial to accurately move the first traction member 320 to the specified position, thereby facilitating the first model 311 to accurately move to the specified position; by using the second transmission rack 520 and the second driving member in the present application to drive the second traction member 330 to move, it is beneficial to accurately move the second traction member 330 to the specified position, thereby facilitating the second model 312 to accurately move to the specified position. In addition, in order to reduce manufacturing costs, the first transmission rack 510 and the second transmission rack 520 have the same structure.

[0048] Reference Figure 7 In one embodiment, a receiving groove 420 is provided on the mounting seat 400, and the driving assembly is installed in the receiving groove 420; a plurality of connecting ports connected to the mounting groove 410 are provided on the groove wall of the receiving groove 420, and the output shaft of the first driving member corresponds to one connecting port and is meshed with the first transmission rack 510 through the corresponding connecting port; the output shaft of the second driving member corresponds to another connecting port and is meshed with the second transmission rack 520 through the corresponding connecting port.

[0049] In this embodiment, the mounting groove 410 is arranged on the first surface of the mounting seat 400, and the accommodating groove 420 is arranged on the second surface of the mounting seat 400. The first surface of the mounting seat 400 and the second surface of the mounting seat 400 are arranged opposite to each other; the first driving member is fixedly installed in the accommodating groove 420, and the second driving member is fixedly installed in the accommodating groove 420. The set accommodating groove 420 not only plays a accommodating role, but also plays a role in reducing the volume of the immunomagnetic separation demonstration device.

[0050] When the immunomagnetic separation demonstration device of the present application is demonstrated, the first driving member drives the first transmission rack 510 to slide on the groove wall of the installation groove 410, thereby driving the first traction member 320 and the first model 311 to move, and the second driving member drives the second transmission rack 520 to slide on the groove wall of the installation groove 410, thereby driving the second traction member 330 and the second model 312 to move. In addition, in order to avoid interference between the first driving member and the second driving member, a spacer 430 is provided between two adjacent connecting ports, and the spacer 430 is fixedly installed on the groove wall of the accommodating groove 420; in order to realize centralized management of the first driving member and the second driving member, the first driving member and the second driving member are both electrically connected to the single-chip microcomputer.

[0051] Reference Figure 4 and Figure 5 In one embodiment, the transmission assembly also includes a first slide rail 530 and a second slide rail 540, the first slide rail 530 is installed on the groove wall of the mounting groove 410, and the first transmission rack 510 is slidably installed on the first slide rail 530; the second slide rail 540 is installed on the groove wall of the mounting groove 410, and the second transmission rack 520 is slidably installed on the second slide rail 540.

[0052] In this embodiment, the first slide rail 530 is fixedly mounted on the groove wall of the mounting groove 410, and the matching mode of the first transmission rack 510 and the first slide rail 530 belongs to the matching mode of the conventional slide bar and the slide rail, which belongs to the common knowledge of the technicians in this field and will not be elaborated in detail here; the second slide rail 540 is fixedly mounted on the groove wall of the mounting groove 410, and the matching mode of the second transmission rack 520 and the second slide rail 540 belongs to the matching mode of the conventional slide bar and the slide rail, which belongs to the common knowledge of the technicians in this field and will not be elaborated in detail here. By adopting the first slide rail 530 in this application, not only the stability of the operation of the first transmission rack 510 is improved, but also it is conducive to accurately moving the first transmission rack 510 to the specified position; by adopting the second slide rail 540 in this application, not only the stability of the operation of the second transmission rack 520 is improved, but also it is conducive to accurately moving the second transmission rack 520 to the specified position. In addition, in order to reduce manufacturing costs, the first slide rail 530 and the second slide rail 540 have the same structure.

[0053] Reference Figure 5 and Figure 6 In one embodiment, the first transmission rack 510 slides on the groove wall of the installation groove 410 along the circumference of the transparent container 100 , and the second transmission rack 520 slides on the groove wall of the installation groove 410 along the circumference of the transparent container 100 .

[0054] In this embodiment, the mounting seat 400 is in the shape of a cuboid, the transparent container 100 is in the shape of a cylinder, the longitudinal section of the mounting groove 410 is semicircular, the cross-section of the mounting groove 410 is rectangular, half of the transparent container 100 is located in the mounting groove 410, and at the same time, the partial structure of the transparent container 100 located in the mounting groove 410 is adapted to the mounting groove 410; the first slide rail 530 and the second slide rail 540 are both semicircular slide rails, the first slide rail 530 and the second slide rail 540 are both fixedly attached to the groove wall of the mounting groove 410, and at the same time, both ends of the first slide rail 530 are flush with the first surface of the mounting seat 400, and both ends of the second slide rail 540 are also flush with the second surface of the mounting seat 400; the first transmission rack 510 and the second transmission rack 520 are both arc-shaped racks with a central angle less than 180°. The first transmission rack 510 designed as above widens the moving range of the first transmission rack 510, thereby widening the moving range of the first traction member 320 and the first model 311; the second transmission rack 520 designed as above widens the moving range of the second transmission rack 520, thereby widening the moving range of the second traction member 330 and the second model 312; by adopting the first transmission rack 510 and the second transmission rack 520 in the present application, it is conducive to more intuitively and vividly demonstrating the separation process of the immunomagnetic separation technology.

[0055] Reference Figure 7In one embodiment, the first transmission rack 510 and the second transmission rack 520 are arranged at intervals along the length direction of the transparent container 100 .

[0056] In this embodiment, the extension direction of the mounting groove 410 is parallel to the length direction of the transparent container 100; the first transmission rack 510 and the second transmission rack 520 designed in this way not only avoid interference between the first traction member 320 and the second traction member 330, but also further widen the movement range of the first traction member 320 and the second traction member 330.

[0057] Reference Figure 2 , Figure 4 as well as Figure 7 In one embodiment, the number of composite components 300 is multiple groups, and the composite components 300 are arranged at intervals along the length direction of the transparent container 100; the number of transmission components is the same as the number of composite components 300, and multiple groups of transmission components are arranged in a one-to-one correspondence with multiple groups of composite components 300; the number of drive components is the same as the number of transmission components, and multiple groups of drive components are arranged in a one-to-one correspondence with multiple groups of transmission components.

[0058] In this embodiment, there are four groups of composite components 300, four groups of transmission components, and four groups of drive components; in other embodiments, the number of composite components 300, transmission components, and drive components can also be other numbers. The multiple groups of composite components 300, transmission components, and drive components are conducive to more intuitively demonstrating the separation process of the immunomagnetic separation technology.

[0059] In summary, the implementation of the immunomagnetic separation demonstration device provided in this embodiment has at least the following beneficial technical effects: when the immunomagnetic separation demonstration device of the present application is demonstrated, the composite part 310 is first placed in a separated state to separate the first model 311 and the second model 312, and the fixed model 200 can be observed. At this time, the fixed model 200 is equivalent to a sample with target molecules, the first model 311 is equivalent to a magnetic carrier, and the second model 312 is equivalent to a specific antibody; then the composite part 310 is switched from the separated state to the combined state, so that the first model 311 and the second model 312 are connected, and the fixed model 200 is shielded by the composite part 310. At this time, the combination of the first model 311, the second model 312 and the fixed model 200 The combination is equivalent to the target-antibody-magnetic carrier complex; then the composite part 310 is switched from the combined state to the separated state again, so that the first model 311 and the second model 312 are separated again, and the fixed model 200 can be observed again. At this time, the fixed model 200 is equivalent to other substances in the sample, the first model 311 is equivalent to the antibody-magnetic carrier complex, and the second model 312 is equivalent to the target molecule; the immunomagnetic separation demonstration device of the present application can intuitively and three-dimensionally demonstrate the separation process of the immunomagnetic separation technology, which is not only conducive to the viewer's understanding and mastery of the principles of the immunomagnetic separation technology, but also conducive to the promotion of the immunomagnetic separation technology; in addition, the transparent container 100 is provided to facilitate the observer to observe the situation inside the transparent container 100.

[0060] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. An immunomagnetic separation demonstration device, characterized in that: include: Transparent container; A fixed model is installed in the transparent container; A composite assembly, the composite assembly comprising a composite part, the composite part comprising: a first model located in the transparent container, the first model being movable in the transparent container; A second model is located in the transparent container, and the second model can move in the transparent container; Among them, the composite part has a combined state and a separated state. When the composite part is in the combined state, the first model and the second model are connected, and the composite part covers the fixed model; when the composite part is in the separated state, the first model and the second model are separated, and the composite part moves relative to the fixed model to expose the fixed model.

2. The immunomagnetic separation demonstration device according to claim 1, characterized in that: The composite assembly further includes: a first traction member, located outside the transparent container, and the first traction member can drive the first model to move in the transparent container; The second traction member is located outside the transparent container, and the second traction member can drive the second model to move in the transparent container.

3. The immunomagnetic separation demonstration device according to claim 2, characterized in that: The first model is a magnetic fluid, the first traction member is a magnetic member, and the first model is connected to the first traction member through magnetic attraction; the second model is a magnetic fluid, the second traction member is a magnetic member, and the second model is connected to the second traction member through magnetic attraction; The fixed model is a flat sticker, and the fixed model is fixedly attached to the inner wall of the transparent container.

4. The immunomagnetic separation demonstration device according to claim 2 or 3, characterized in that: The immunomagnetic separation demonstration device also includes a mounting seat, which is provided with a mounting groove, and the transparent container is installed in the mounting groove; the first traction member can slide on the groove wall of the mounting groove, and the second traction member can slide on the groove wall of the mounting groove.

5. The immunomagnetic separation demonstration device according to claim 4, characterized in that: The immunomagnetic separation demonstration device also includes a transmission assembly, the transmission assembly includes a first transmission rack and a second transmission rack, the first traction member is installed on the first transmission rack, and the first transmission rack can slide on the groove wall of the installation groove; the second traction member is installed on the second transmission rack, and the second transmission rack can slide on the groove wall of the installation groove in a direction close to or away from the first transmission rack; The immunomagnetic separation demonstration device further includes a driving assembly, wherein the driving assembly includes a first driving member and a second driving member, wherein an output shaft of the first driving member is drivingly connected to the first transmission rack to drive the first transmission rack to slide; The output shaft of the second driving member is drivingly connected to the second transmission rack to drive the second transmission rack to slide.

6. The immunomagnetic separation demonstration device according to claim 5, characterized in that: The mounting seat is provided with a receiving groove, and the driving assembly is installed in the receiving groove; The groove wall of the accommodating groove is provided with a plurality of communicating ports connected with the mounting groove, the output shaft of the first driving member corresponds to one of the communicating ports, and is meshed with the first transmission rack through the corresponding communicating port; the output shaft of the second driving member corresponds to another of the communicating ports, and is meshed with the second transmission rack through the corresponding communicating port.

7. The immunomagnetic separation demonstration device according to claim 5, characterized in that: The transmission assembly also includes a first slide rail and a second slide rail, the first slide rail is installed on the groove wall of the mounting groove, and the first transmission rack is slidably installed on the first slide rail; the second slide rail is installed on the groove wall of the mounting groove, and the second transmission rack is slidably installed on the second slide rail.

8. The immunomagnetic separation demonstration device according to claim 5, characterized in that: The first transmission rack slides on the groove wall of the installation groove along the circumference of the transparent container, and the second transmission rack slides on the groove wall of the installation groove along the circumference of the transparent container.

9. The immunomagnetic separation demonstration device according to claim 5, characterized in that: The first transmission rack and the second transmission rack are arranged at intervals along the length direction of the transparent container.

10. The immunomagnetic separation demonstration device according to claim 5, characterized in that: The number of the composite components is multiple, and the composite components are arranged at intervals along the length direction of the transparent container; The number of the transmission components is the same as the number of the composite components, and multiple groups of the transmission components are arranged in one-to-one correspondence with multiple groups of the composite components; The number of the driving components is the same as the number of the transmission components, and multiple groups of the driving components are arranged in a one-to-one correspondence with multiple groups of the transmission components.

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