Multi-path trace reagent strip automatic filling device

Abstract

The utility model relates to the technical field of reagent filling, in particular to an automatic filling device for multi-path trace reagent strips. Comprising an industrial control screen, a pipetting and filling module, an eccentric oscillation and uniform mixing module, a metering pump set, a reagent strip set, an electronic control module, a power supply, a plurality of to-be-filled reagent tanks, a cleaning liquid tank, a three-in-one power socket, a three-way electromagnetic valve set, a bottom plate and a three-dimensional H-shaped frame, the pipetting and filling module comprises a fixed plate, an X-axis motor, a conveyor belt I, an optocoupler I, a sliding rail, an L-shaped fixed bracket, a Z-axis motor, a conveyor belt II, a guide rail, an optocoupler II and a placement frame; the eccentric oscillation and uniform mixing module comprises a stepping motor, a positioning plate, an eccentric shaft, a bearing, a bearing seat, a damping rubber pad, a mounting plate, a balancing weight I, a balancing weight II, a feedback control optocoupler, an optocoupler separation blade and a tray; the multi-path synchronous different-quantity high-precision automatic filling device can realize multi-path synchronous different-quantity high-precision automatic filling of trace reagents, is high in accuracy and convenient to operate, and improves the working efficiency.

Description

Technical Field

[0001] The utility model relates to the technical field of reagent filling, in particular to an automatic filling device for multi-channel micro-reagent strips. Background Art

[0002] With the rapid development of detection technology, the role of in vitro diagnostic reagent detection in clinical diagnosis has become increasingly prominent. However, in actual applications, many in vitro diagnostic reagents are difficult to handle with traditional manual packaging methods due to their small packaging volume (<500μl), high requirements for precision, throughput limitations, and the inability to fill multiple reagents at the same time. In addition, the filling machines currently on the market are mostly long and streamlined, which take up a lot of space and are difficult to adapt to places with limited space. More importantly, during the filling process, the existing reagent filling device often requires multiple filling heads corresponding to the holes in the reagent strip to work synchronously. Since the amount of reagents required for different holes is not the same, synchronous filling often leads to the consistency of the amount of reagents, which in turn causes waste of reagents. Therefore, how to effectively solve these problems and improve the detection efficiency and accuracy of in vitro diagnostic reagents has become a difficult problem that needs to be overcome urgently. Utility Model Content

[0003] The utility model aims to provide a multi-channel micro-reagent strip automatic filling device to solve the above problems.

[0004] In order to achieve the above objectives, the following technical solutions are provided:

[0005] A multi-channel micro-reagent strip automatic filling device comprises: an industrial control screen, a liquid transfer filling module, an eccentric oscillation mixing module, a metering pump group, a reagent strip group, an electronic control module, a power supply, a plurality of reagent tanks to be filled, a cleaning liquid tank, a three-in-one power socket, a three-way solenoid valve group, a bottom plate and a three-dimensional H-shaped frame, wherein the three-dimensional H-shaped frame is arranged on the bottom plate, a back plate is arranged at the rear side of the three-dimensional H-shaped frame, a crossbeam is arranged at the top of the front side of the three-dimensional H-shaped frame, the industrial control screen is fixedly connected to the crossbeam, the electronic control module is arranged on the back plate, the liquid transfer filling module is arranged at the front end of the three-dimensional H-shaped frame, the eccentric oscillation mixing module is arranged on the bottom plate, and the three-dimensional H-shaped frame is provided with a back plate. Inside the three-dimensional H-shaped frame, the metering pump group is arranged on a side wall of the beam, the reagent strip group is arranged on the bottom plate, corresponding to the position below the pipetting and filling module, the electronic control module is arranged on a side surface of the back plate, the power supply is arranged on a side surface of the back plate, the various reagent tanks to be filled are arranged on the eccentric oscillation and mixing module, the cleaning liquid tank is arranged on the bottom plate, located in the three-dimensional H-shaped frame, and located on one side of the eccentric oscillation and mixing module, the three-in-one power socket is fixedly connected to the back plate and electrically connected to the power supply, the three-way solenoid valve group is arranged on the back plate, one end of which is connected to the metering pump group, and the other end is connected to the various reagent tanks to be filled.

[0006] Preferably, the liquid transfer and filling module comprises: a fixed plate, an X-axis motor, a conveyor belt 1, an optical coupler 1, a slide rail, an L-shaped fixed bracket, a Z-axis motor, a conveyor belt 2, a guide rail, an optical coupler 2 and a placement rack. The fixed plate is fixedly connected to the front end of the three-dimensional H-shaped frame. The X-axis motor is fixedly connected to one end of the fixed plate, and its output end passes through the fixed plate and is connected to one end of the conveyor belt 1. The other end of the conveyor belt 1 is connected to the fixed plate. The slide rail is fixedly connected to the fixed plate and is located at the front side of the conveyor belt 1. The slide rail is provided with a slider that is slidably connected thereto. One side of the slider is fixedly connected to the conveyor belt 1. The L-shaped fixed bracket is fixedly connected to the other side of the slider, the optical coupler 1 is arranged on the fixed plate, away from the X-axis motor, the Z-axis motor is fixedly connected to the top of the L-shaped fixed bracket, and its output end is connected to one end of the second conveyor belt, and the other end of the second conveyor belt is connected to the L-shaped fixed bracket. The guide rail is fixedly connected to the L-shaped fixed bracket, and the guide rail is provided with a walking block that is slidably connected thereto, one side of the walking block is fixedly connected to the second conveyor belt, and the other side of the walking block is fixedly connected to the placement rack, the optical coupler 2 is arranged on the L-shaped fixed bracket, located on one side of one end of the guide rail, and the placement rack is also provided with multiple groups of injection needles.

[0007] Preferably, the eccentric oscillation mixing module includes: a stepper motor, a positioning plate, a certain number of eccentric shafts, a certain number of bearings, a bearing seat, a certain number of shock-absorbing rubber pads, a mounting plate, a counterweight block 1, a counterweight block 2, a feedback control optical coupler, an optical coupler baffle and a tray. The bottom of the stepper motor is fixedly connected to the bottom plate, and the other side of the stepper motor is connected and fixed to the positioning plate. A certain number of shock-absorbing rubber pads are evenly distributed at both ends of the positioning plate. A certain number of bearings are evenly distributed in the middle of the positioning plate. Each of the bearings is equipped with an eccentric shaft, and each of the upper ends of the eccentric shafts is equipped with a bearing. Each bearing located at the upper end of the eccentric shaft is arranged on the bearing seat. The eccentric shaft located at the center position is also provided with a counterweight block 2. The mounting plate is a frame structure, which is sleeved on the outside of the bearing seat, and its bottom is fixedly connected to a certain number of shock-absorbing rubber pads. The counterweight block 1 is a frame structure, which is sleeved on the outside of the stepper motor and is relatively fixed to the bearing seat through a connecting rod. The tray is fixedly connected to the mounting plate.

[0008] Preferably, the industrial control panel is provided with a host computer management system for controlling the start and stop of various parts of the device.

[0009] Preferably, the metering pump group, three-way solenoid valve group, multiple groups of injection needles, multiple reagent tanks to be filled, and cleaning liquid tanks are connected through pipelines and controlled by a host computer management system to enable the device to perform filling or cleaning work.

[0010] Preferably, the reagent strip set is a boat-shaped reagent strip, which can be adapted to different hole arrangement modes of the reagent strip.

[0011] The beneficial effects of the utility model are:

[0012] The utility model discloses the ... BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a structural schematic diagram of the utility model;

[0014] Figure 2 It is a rear view of the utility model;

[0015] Figure 3 This is a structural schematic diagram of the liquid transfer and filling module of the utility model;

[0016] Figure 4 This is a structural schematic diagram of the eccentric oscillation mixing module of the utility model;

[0017] Figure 5 This is a flow chart of an embodiment of the utility model;

[0018] The reference numerals shown in the figures are:

[0019] 1-Industrial control screen;

[0020] 2-pipette filling module, 201-Z-axis motor, 202-X-axis motor, 203-multiple injection needles, 204-fixed plate, 205-conveyor belt 1, 206-optical coupler 1, 207-slide rail, 208-L-shaped fixed bracket, 209-conveyor belt 2, 210-guide rail, 211-optical coupler 2, 212-placing rack, 213-walking block, 214-slider;

[0021] 3-eccentric oscillation mixing module, 301-stepping motor, 302-positioning plate, 303-eccentric shaft, 304-bearing, 305-bearing seat, 306-shock-absorbing rubber pad, 307-mounting plate, 308-counterweight block 1, 309-counterweight block 2, 310-feedback control optical coupler, 311-optical coupler baffle, 312-tray;

[0022] 4-metering pump set;

[0023] 5-Three-way solenoid valve group;

[0024] 6-reagent strip set;

[0025] 7- Electronic control module;

[0026] 8- Power supply;

[0027] 9- Various reagent tanks to be filled;

[0028] 10-cleaning fluid tank;

[0029] 11- Three-in-one power socket;

[0030] 12- beam;

[0031] 13- bottom plate;

[0032] 14-Three-dimensional H-shaped frame;

[0033] 15- back plate; DETAILED DESCRIPTION

[0034] The design scheme is described in detail below with reference to the accompanying drawings.

[0035] like Figures 1 to 5 As shown, a multi-channel micro-reagent strip automatic filling device includes: an industrial control screen 1, a pipetting filling module 2, an eccentric oscillation mixing module 3, a metering pump group 4, a reagent strip group 6, an electronic control module 7, a power supply 8, a plurality of reagent tanks to be filled 9, a cleaning liquid tank 10, a three-in-one power socket 11, a three-way solenoid valve group 5, a bottom plate 13 and a three-dimensional H-shaped frame 14, the three-dimensional H-shaped frame 14 is arranged on the bottom plate 13, a back plate 15 is arranged on the rear side of the three-dimensional H-shaped frame 14, a crossbeam 12 is arranged on the top of the front side of the three-dimensional H-shaped frame 14, the industrial control screen 1 is fixedly connected to the crossbeam 12, the electronic control module 7 is arranged on the back plate 15, and is electrically connected to the industrial control screen 1. It is a lower computer of the upper computer management system in the industrial control screen 1, and receives instructions from the industrial control screen 1 to control the work of other modules. The industrial control screen 1 is used to control and operate the entire instrument, and the operator uses the upper computer management system by manipulating the screen , record and display real-time data, and have a safety lock function, the pipetting and filling module 2 is arranged at the front end of the three-dimensional H-shaped frame 14, the eccentric oscillation and mixing module 3 is arranged on the bottom plate 13, and is located inside the three-dimensional H-shaped frame 14, the metering pump group 4 is arranged on a side wall of the beam 12, and the reagent strip group 6 is arranged on the bottom plate 13, correspondingly located below the pipetting and filling module 2, the electronic control module 7 is arranged on a side surface of the back plate 15, the power supply 8 is arranged on a side surface of the back plate 15, and a variety of reagent tanks 9 to be filled are arranged on the eccentric oscillation and mixing module 3, the cleaning liquid tank 10 is arranged on the bottom plate 13, located in the three-dimensional H-shaped frame 14, and located on one side of the eccentric oscillation and mixing module 3, the three-in-one power socket 11 is fixedly connected to the back plate 15, and is electrically connected to the power supply 8, and the three-way solenoid valve group 5 is arranged on the back plate 15, one end of which is connected to the metering pump group 4, and the other end is connected to the variety of reagent tanks 9 to be filled.

[0036] In some embodiments, the liquid transfer filling module 2 is responsible for multi-circuit filling of the reagent strip group 6. Two sets of feedback control optical couplers 206 and optical couplers 211 are used for resetting the X-axis and Z-axis motors 201 respectively, including: a fixed plate 204, an X-axis motor 202, a conveyor belt 205, an optical coupler 206, a slide rail 207, an L-shaped fixed bracket 208, a Z-axis motor 201, a conveyor belt 209, a guide rail 210, an optical coupler 211 and a placement rack 212. The fixed plate 204 is fixedly connected to the front end of the three-dimensional H-shaped frame 14, the X-axis motor 202 is fixedly connected to one end of the fixed plate 204, and its output end passes through the fixed plate 204 and is connected to one end of the conveyor belt 205, and the other end of the conveyor belt 205 is connected to the fixed plate 204. The slide rail 207 is fixedly connected to the fixed plate 204 and is located correspondingly on the front side of the conveyor belt 205. The slide rail 207 is provided with a A slider 214 is slidably connected, one side of the slider 214 is fixedly connected to the conveyor belt 205, an L-shaped fixed bracket 208 is fixedly connected to the other side of the slider 214, an optical coupler 206 is arranged on the fixed plate 204, away from the X-axis motor 202, the Z-axis motor 201 is fixedly connected to the top of the L-shaped fixed bracket 208, and its output end is connected to one end of the conveyor belt 209, and the other end of the conveyor belt 209 is connected to the L-shaped fixed bracket 208, the guide rail 210 is fixedly connected to the L-shaped fixed bracket 208, and the guide rail 210 is provided with a walking block 213 slidably connected thereto, one side of the walking block 213 is fixedly connected to the conveyor belt 209, and the other side is fixedly connected to the placement rack 212, the optical coupler 211 is arranged on the L-shaped fixed bracket 208, located on one side of one end of the guide rail 210, and a plurality of groups of injection needles 203 are also provided on the placement rack 212.

[0037] In some embodiments, the eccentric oscillation and mixing module 3 is used to oscillate and mix the various reagent tanks 9 to be filled placed on the tray 312 to prevent the phenomenon of insufficient filling concentration due to reagent precipitation. When working, the 42 stepper motor 301 drives the eccentric shaft 303 to rotate to realize the eccentric oscillation and mixing function, and the speed is adjustable. The feedback control optical coupler 310 is used to reset the rotating tray 312, including: a stepper motor 301, a positioning plate 302, a certain number of eccentric shafts 303, a certain number of bearings 304, a bearing seat 305, a certain number of shock-absorbing rubber pads 306, a mounting plate 307, a counterweight block 1 308, a counterweight block 2 309, a feedback control optical coupler 310, an optical coupler baffle 311 and a tray 312. The bottom of the stepper motor 301 is fixedly connected to the bottom plate 13, and the other side thereof is fixedly connected to the positioning plate 302 A certain number of shock-absorbing rubber pads 306 are evenly distributed at both ends of the positioning plate 302, a certain number of bearings 304 are evenly distributed in the middle of the positioning plate 302, each bearing 304 is equipped with an eccentric shaft 303, and each eccentric shaft 303 has a bearing 304 at the upper end. Each bearing 304 located at the upper end of the eccentric shaft 303 is evenly distributed on the bearing seat 305, and a counterweight block 309 is also provided on the eccentric shaft 303 located at the center. The mounting plate 307 is a frame structure, which is sleeved on the outside of the bearing seat 305 and separated from it. The bottom of the mounting plate is fixedly connected to a certain number of shock-absorbing rubber pads 306, and the counterweight block 308 is a frame structure, which is sleeved on the outside of the stepper motor 301 and is relatively fixed to the bearing seat 305 through a connecting rod. The tray 312 is fixedly connected to the mounting plate 307.

[0038] In some embodiments, a host computer management system is provided in the industrial control screen 1 for controlling the start and stop of various parts of the device. The main functions of the host computer management system include system motion control, filling number setting, filling quantity setting, etc., filling cleaning conversion, data recording and storage, etc.

[0039] In some embodiments, the metering pump group 4, the three-way solenoid valve group 5, multiple groups of injection needles 203, multiple reagent tanks to be filled 9, and the cleaning liquid tank 10 are connected by pipelines and controlled by the host computer management system to enable the device to perform filling or cleaning work, wherein the metering pump group 4 is responsible for pumping liquid, and each metering pump is independently responsible for filling a reagent without interfering with each other. Each metering pump in the metering pump group 4 corresponds to an injection needle respectively to ensure multi-channel sample addition of different amounts, and the three-way solenoid valve group 5 is responsible for switching the connection of the outflowing liquid.

[0040] In some embodiments, the reagent strip set 6 is a boat-shaped reagent strip, which can be adapted to different hole arrangement modes of the reagent strip.

[0041] Example

[0042] like Figures 1 to 5 As shown, the steps are as follows:

[0043] 1. After the device starts up and self-checks, the pipetting and filling module 2 is reset, and the industrial control screen 1 prompts that the system is running normally, the operator is prompted to clean the pipeline through the industrial control screen 1 before the first filling, and set the sample adding position, sample adding amount and sample adding times to be filled later, and the system accepts the instructions and works;

[0044] 2. After receiving the command, the three-way solenoid valve group 5 opens the valve on the cleaning liquid tank 10, and the metering pump group 4 pumps the cleaning liquid into the pipeline to clean the pipeline, and discharges the cleaning liquid from the multiple injection needles 203 at a certain position;

[0045] 3. After cleaning is completed, the filling work begins, the eccentric oscillation mixing module 3 starts shaking, the three-way solenoid valve group 5 receives the command, opens the valves on the sides of the various reagent tanks 9 to be filled, and the metering pump group 4 starts pumping liquid;

[0046] 4. The two-axis motors of the pipetting and filling module 2 work, the X axis moves to the specified position, and the Z axis moves to the corresponding filling slot of the reagent strip group 6, and the filling is carried out in sequence and in a timely manner;

[0047] 5. Repeat the above process according to the instructions of the host computer until all filling is completed, the system stops working, and prompts the operator to take away the reagent strip;

[0048] 6. The system organizes relevant data information, stores it and uploads it for display to the operator.

Claims

1. A multi-channel micro-reagent strip automatic filling device, characterized in that: include: An industrial control screen, a pipetting and filling module, an eccentric oscillation and mixing module, a metering pump group, a reagent strip group, an electronic control module, a power supply, a variety of reagent tanks to be filled, a cleaning liquid tank, a three-in-one power socket, a three-way solenoid valve group, a bottom plate and a three-dimensional H-shaped frame. The three-dimensional H-shaped frame is arranged on the bottom plate, a back plate is arranged at the rear side of the three-dimensional H-shaped frame, a crossbeam is arranged at the top of the front side of the three-dimensional H-shaped frame, the industrial control screen is fixedly connected to the crossbeam, the electronic control module is arranged on the back plate, the pipetting and filling module is arranged at the front end of the three-dimensional H-shaped frame, and the eccentric oscillation and mixing module is arranged on the bottom plate, located inside the three-dimensional H-shaped frame. The metering pump group is arranged on a side wall of the beam, the reagent strip group is arranged on the bottom plate, corresponding to the position below the pipetting and filling module, the electronic control module is arranged on a side surface of the back plate, the power supply is arranged on a side surface of the back plate, the various reagent tanks to be filled are arranged on the eccentric oscillation and mixing module, the cleaning liquid tank is arranged on the bottom plate, located in the three-dimensional H-shaped frame, and located on one side of the eccentric oscillation and mixing module, the three-in-one power socket is fixedly connected to the back plate and electrically connected to the power supply, the three-way solenoid valve group is arranged on the back plate, one end of which is connected to the metering pump group, and the other end is connected to the various reagent tanks to be filled.

2. The automatic filling device for multi-channel micro-reagent strips according to claim 1, characterized in that: The liquid transfer and filling module includes: a fixed plate, an X-axis motor, a conveyor belt 1, an optical coupler 1, a slide rail, an L-shaped fixed bracket, a Z-axis motor, a conveyor belt 2, a guide rail, an optical coupler 2 and a placement rack. The fixed plate is fixedly connected to the front end of the three-dimensional H-shaped frame, the X-axis motor is fixedly connected to one end of the fixed plate, and its output end passes through the fixed plate and is connected to one end of the conveyor belt 1. The other end of the conveyor belt 1 is connected to the fixed plate. The slide rail is fixedly connected to the fixed plate and is located at the front side of the conveyor belt 1. The slide rail is provided with a slider that is slidably connected therewith. One side of the slider is fixedly connected to the conveyor belt 1. The L The L-shaped fixed bracket is fixedly connected to the other side of the slider, the optical coupler 1 is arranged on the fixed plate, away from the X-axis motor, the Z-axis motor is fixedly connected to the top of the L-shaped fixed bracket, and its output end is connected to one end of the conveyor belt 2, and the other end of the conveyor belt 2 is connected to the L-shaped fixed bracket, the guide rail is fixedly connected to the L-shaped fixed bracket, and the guide rail is provided with a walking block that is slidably connected thereto, one side of the walking block is fixedly connected to the conveyor belt 2, and the other side of the walking block is fixedly connected to the placement rack, the optical coupler 2 is arranged on the L-shaped fixed bracket, located on one side of one end of the guide rail, and the placement rack is also provided with multiple groups of injection needles.

3. The automatic filling device for multi-channel micro-reagent strips according to claim 1, characterized in that: The eccentric oscillation mixing module includes: a stepper motor, a positioning plate, a certain number of eccentric shafts, a certain number of bearings, a bearing seat, a certain number of shock-absorbing rubber pads, a mounting plate, a counterweight block 1, a counterweight block 2, a feedback control optical coupler, an optical coupler baffle and a tray. The bottom of the stepper motor is fixedly connected to the bottom plate, and the other side of the stepper motor is connected and fixed to the positioning plate. A certain number of shock-absorbing rubber pads are evenly distributed at both ends of the positioning plate. A certain number of bearings are evenly distributed in the middle of the positioning plate. Each of the bearings is equipped with an eccentric shaft, and each of the upper ends of the eccentric shafts is equipped with a bearing. Each bearing located at the upper end of the eccentric shaft is arranged on the bearing seat, and a counterweight block 2 is also provided on the eccentric shaft located at the center. The mounting plate is a frame structure, which is sleeved on the outside of the bearing seat, and its bottom is fixedly connected to a certain number of shock-absorbing rubber pads. The counterweight block 1 is a frame structure, which is sleeved on the outside of the stepper motor and is relatively fixed to the bearing seat through a connecting rod. The tray is fixedly connected to the mounting plate.

4. The automatic filling device for multi-channel micro-reagent strips according to claim 1, characterized in that: The industrial control panel is provided with a host computer management system for controlling the start and stop of various parts of the device.

5. The automatic filling device for multi-channel micro-reagent strips according to claim 1, characterized in that: The metering pump group, three-way solenoid valve group, multiple groups of injection needles, multiple reagent tanks to be filled, and cleaning liquid tanks are connected through pipelines and controlled by a host computer management system to enable the device to perform filling or cleaning work.

6. The automatic filling device for multi-channel micro-reagent strips according to claim 1, characterized in that: The reagent strip set is a boat-shaped reagent strip, which can be adapted to different hole arrangement modes of the reagent strip.

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