Chromatographic extraction device for glabridin

Abstract

The utility model relates to the technical field of glabridin extraction, and discloses a chromatographic extraction device for glabridin, which comprises a chromatographic column, a bracket and a mounting box, and hoops for connecting the chromatographic column with two vertical rods are arranged on the outer side of the chromatographic column at equal intervals; two bearing seats are arranged on the two sides of the top of the support, and the two vertical rods are fixedly sleeved with a rotating shaft rotationally connected with the two bearing seats. A bevel gear set fixedly connected with the input end of one rotating shaft is rotationally arranged in the mounting box, a self-locking hand-cranking wheel for driving the bevel gear set to act is arranged on the outer side of the mounting box, and the bevel gear set is driven by rotating the self-locking hand-cranking wheel. The hand-cranking wheel drives the bevel gear set to rotate, so that the position of the rotating shaft is adjusted, and the angle and the direction of the chromatographic column are changed. The device can quickly adjust the angle of the chromatographic column as required.

Description

Technical Field

[0001] The utility model relates to the field of chromatography extraction devices, in particular to a chromatography extraction device for glabridin. Background Art

[0002] The chromatography column is the main body of gel chromatography technology, generally made of glass tubes, or plexiglass tubes, or metal tubes; it is a chromatography method that separates the components in the sample mixture according to their different distribution coefficients in the stationary phase and the mobile phase. The chromatography column can be used to extract the active ingredients in Chinese herbal medicines. Taking glycyrrhiza glabra as an example, first boil and filter the licorice glabra extract, add the licorice glabra extract to the chromatography column, and elute it with a specified concentration of ethanol solution for multiple times to obtain a solution containing glycyrrhiza glabra. The chromatography separation and extraction efficiency is high, and it can ensure the purity of each component and better retain its activity.

[0003] The chromatography column in the prior art is fixed, fixed vertically and cannot be rotated to adjust the angle; such a design is not convenient for daily maintenance of the upper structure of the chromatography column. Therefore, in order to better meet the actual needs, we propose a chromatography column that can be rotated to improve its applicability and efficiency. Utility Model Content

[0004] In view of the above problems, the utility model aims to provide a chromatographic extraction device for glabridin.

[0005] To achieve this technical purpose, the solution of the utility model is:

[0006] A chromatographic extraction device for glabridin comprises a chromatographic column, a bracket and an installation box, wherein hoops connecting the chromatographic column and two vertical poles are arranged at equal distances on the outside of the chromatographic column; two bearing seats are arranged on both sides of the top of the bracket, and a rotating shaft rotatably connected to the two bearing seats is fixedly sleeved outside the two vertical poles; a bevel gear set rotatably fixedly connected to the input end of one of the rotating shafts is rotatably provided in the installation box, and a self-locking hand-cranked wheel for driving the bevel gear set is arranged on the outside of the installation box, and the bevel gear set and the rotating shaft are driven to rotate by rotating the self-locking hand-cranked wheel to adjust the angle of the chromatographic column.

[0007] The hand-cranked wheel drives the bevel gear set to rotate, thereby adjusting the position of the rotating shaft, thereby changing the angle and direction of the chromatography column. This device can quickly adjust the angle of the chromatography column as needed to meet the separation requirements of different substances and improve the extraction efficiency.

[0008] By driving the bevel gear set and the rotating shaft through the self-locking hand-cranked wheel, the angle of the chromatography column can be quickly adjusted to meet the separation requirements of different substances and improve the separation effect.

[0009] Preferably, the chromatography column comprises a cylinder, a cylinder cover and a base, a filter element is provided between the cylinder and the base, the clamp on the cylinder cover is locked and fixed with the clamp at the top of the cylinder by bolt A, and the clamp on the base is locked and fixed with the clamp at the bottom of the cylinder by bolt B. By locking and fixing the clamp by bolts A and bolts B, the chromatography column can be quickly installed or removed.

[0010] Preferably, the clamp includes two semicircular rings fixed together by screws and encircling the outside of the chromatography column, a sleeve rod located outside the two semicircular rings and sleeved on the outer side of the vertical pole, and a mounting block with holes arranged outside the semicircular rings and threadedly connected to the bolt A or the bolt B, and the sleeve rod is fixed to the vertical pole by a locking screw.

[0011] Preferably, a sleeve column sleeved on the outer side of the vertical pole is fixedly connected to the rotating shaft, and the sleeve column is fixed to the vertical pole by a locking screw.

[0012] Preferably, the bottom support is connected to a drain pipe, and the drain pipe is provided with a drain valve to facilitate the discharge of liquid remaining in the chromatography column after the chromatography process is completed.

[0013] Preferably, the filter element comprises an outer sleeve and a sand core arranged inside the outer sleeve. The upper and lower ends of the outer sleeve are respectively provided with annular concave grooves for matching the cylinder body and the bottom bracket for insertion and positioning. The sand core can increase the filtering area and improve the filtering efficiency.

[0014] Preferably, the self-locking hand wheel can be replaced by a motor to control the rotation of the bevel gear set and the rotating shaft to accurately adjust the angle of the chromatography column.

[0015] Preferably, the drain pipe on the base is arranged obliquely to the center line of the chromatography column.

[0016] Preferably, the sand core is made of porous ceramic material to improve filtering efficiency.

[0017] The technical effects and advantages of the utility model are as follows: the chromatographic extraction device for glabridin can quickly and accurately adjust the angle of the chromatography column through a hand-cranked wheel or a bevel gear set driven by a motor to adapt to different needs and improve the separation effect and extraction efficiency. The design of the clamp, sleeve rod, sleeve column and filter element ensures a stable connection between the chromatography column and the bracket and the vertical pole, thereby improving the durability of the entire device.

[0018] The design of the drain valve prevents liquid from overflowing or splashing, reducing the safety risk of operators. The residual liquid can be quickly discharged through the drain pipe and drain valve, saving time and cost and improving the efficiency of chromatographic extraction. The combination of the outer sleeve and the sand core provides an effective filtration mechanism, increases the filtration area, improves the filtration efficiency, and ensures the purity and quality of the chromatographic extraction.

[0019] In summary, this chromatographic extraction device, through its unique design, achieves flexible adjustment of the chromatographic column, improves stability and durability, while improving the safety and efficiency of the chromatographic extraction operation, ensuring the separation effect and extraction quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the structure of the utility model;

[0021] Figure 2 It is an exploded view of the utility model;

[0022] Figure 3 It is the front view of the utility model;

[0023] Figure 4 This is a schematic diagram of the structure of the clamp of the utility model;

[0024] Figure 5 It is a structural schematic diagram of the filter element of the utility model.

[0025] In the figure: 1, chromatography column; 2, vertical pole; 3, clamp; 301, semicircular arc ring; 302, sleeve rod; 303, mounting block with hole; 4, bracket; 5, bearing seat; 6, rotating shaft; 7, mounting box; 8, self-locking hand crank; 9, cylinder; 10, cylinder cover; 11, bottom support; 12, filter element; 1201, outer sleeve; 1202, sand core; 1203, annular concave groove; 13, bolt A; 14, bolt B; 15, sleeve column; 16, drain pipe; 17, drain valve. DETAILED DESCRIPTION

[0026] The utility model of the present application is further described in detail below in conjunction with the accompanying drawings and specific embodiments. In order to clearly and completely describe the technical solution, the following embodiments are selected for illustration; based on the contents recorded in this application, other embodiments obtained without creative work are all within the scope of protection of this utility model.

[0027] In the following embodiments, it should be noted that the terms "upper", "lower", "left", "right", "inside", "outside", "top / bottom" and other orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of clearly describing the present embodiment, rather than indicating or implying that the device or element referred to must have a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0028] The following is combined with Figure 1-5 To further explain this application in detail,

[0029] The embodiment of the present application discloses a chromatography extraction device for glabridin, comprising a chromatography column 1, a bracket 4 and an installation box 7, wherein the outer side of the chromatography column 1 is provided with hoops 3 connecting it to two upright poles 2 arranged at equal distances; two bearing seats 5 are provided on both sides of the top of the bracket 4, and a rotating shaft 6 rotatably connected to the two bearing seats 5 is fixedly sleeved outside the two upright poles 2; a bevel gear set rotatably provided in the installation box 7 and fixedly connected to the input end of one of the rotating shafts 6, and a self-locking hand-cranked wheel 8 for driving the bevel gear set to move is provided on the outer side of the installation box 7, and the bevel gear set and the rotating shaft 6 are driven to rotate by rotating the self-locking hand-cranked wheel 8 to adjust the angle of the chromatography column 1, and the self-locking hand-cranked wheel 8 can be replaced by a motor to control the rotation of the bevel gear set and the rotating shaft 6 to accurately adjust the angle of the chromatography column 1.

[0030] The bevel gear set is driven to rotate by the hand-cranked wheel, thereby adjusting the position of the rotating shaft 6, thereby changing the angle and direction of the chromatography column 1. This device can quickly adjust the angle of the chromatography column 1 as needed.

[0031] By driving the bevel gear set and the rotating shaft 6 to rotate through the self-locking hand wheel 8, the angle of the chromatography column 1 can be quickly adjusted. The angle of the chromatography column 1 can be adjusted by simply rotating the hand wheel without complicated operating steps. In addition, the self-locking hand wheel 8 can be replaced with a motor to control the rotation angle, and the position of the chromatography column 1 can be accurately adjusted as needed.

[0032] The chromatography column 1 includes a barrel 9, a barrel cover 10 and a base 11, a filter 12 is provided between the barrel 9 and the base 11, the clamp 3 on the barrel cover 10 is locked and fixed with the clamp 3 at the top of the barrel 9 by bolts A13, and the clamp 3 on the base 11 is locked and fixed with the clamp 3 at the bottom of the barrel 9 by bolts B14.

[0033] By providing a filter 12 between the barrel 9 and the base 11 of the chromatography column 1, leakage or contamination of the sample solution can be prevented during the chromatography process, thereby ensuring the stability and reliability of the chromatography extraction. The design of the clamp 3 makes the assembly and disassembly of the chromatography column 1 simple and quick. The clamp 3 is locked and fixed by bolts A13 and B14, so that the chromatography column 1 can be quickly installed or disassembled.

[0034] The clamp 3 includes two semicircular rings 301 fixed together by screws and encircling the outside of the chromatography column 1, a sleeve rod 302 located outside the two semicircular rings 301 and sleeved on the outer side of the vertical pole 2, and a mounting block 303 with holes arranged outside the semicircular rings 301 and threadedly connected to the bolt A13 or the bolt B14. The sleeve rod 302 is fixed to the vertical pole 2 by locking screws.

[0035] The rotating shaft 6 is fixedly connected with a sleeve column 15 sleeved on the outer side of the vertical pole 2. The sleeve column 15 is fixed on the vertical pole 2 by a locking screw.

[0036] The sleeve column 15 on the rotating shaft 6 can be fixed to the vertical pole 2 by means of locking screws, which makes the docking of the vertical pole 2 and the rotating shaft 6 simple, convenient and quick. The sleeve rod 302 is locked and fixed to the vertical pole 2 by means of locking screws, which makes the connection and fixation between the clamp 3 and the vertical pole 2 simple and convenient. By using locking screws to fix the sleeve rod 302 and the sleeve column 15, a firm connection between the components can be ensured, thereby improving the durability and durability of the entire device.

[0037] The bottom support 11 is connected to a drain pipe 16, and a drain valve 17 is provided on the drain pipe 16 to facilitate the removal of the liquid remaining in the chromatography column 1 after the chromatography process is completed. This helps to reduce sample waste and improve the efficiency of chromatography extraction. The drain valve 17 can control the speed and flow of the drainage to avoid damage to the structure of the chromatography column 1 due to excessively fast drainage;

[0038] The drain pipe 16 on the base 11 is arranged at an angle to the center line of the chromatography column 1 to facilitate the discharge of residual liquid. When the residual liquid in the chromatography column 1 needs to be discharged, the inclined drain pipe 16 can use gravity to make the residual liquid flow out naturally along the pipeline, avoiding the problem that the residual liquid cannot be completely discharged due to the horizontal arrangement, which is conducive to reducing sample waste and improving chromatography efficiency.

[0039] The filter element 12 includes an outer sleeve 1201 and a sand core 1202 disposed inside the outer sleeve 1201 . The upper and lower ends of the outer sleeve 1201 are respectively provided with annular concave grooves 1203 for fitting the cylinder body 9 and the bottom bracket 11 for insertion and positioning.

[0040] The combination of the outer sleeve 1201 and the sand core 1202 provides an effective filtering mechanism. The sand core 1202 can increase the filtering area and improve the filtering efficiency. The design of the annular concave groove 1203 of the outer sleeve 1201 helps to better position the cylinder 9 and the bottom support 11, ensuring the stability of the chromatography column 1. The sand core 1202 is made of porous ceramic material to improve the filtering efficiency. The porous ceramic material has the advantages of high strength, corrosion resistance, and high filtering accuracy. The sand core 1202 made of this material has a large filtering area and high filtering efficiency. It can better filter out impurity particles in the sample solution and ensure the purity of the extract (glabridin is extracted from the roots or stems of Glycyrrhiza glabra, with a low content. Only about 90 grams of glabridin can be extracted from 1 ton of Glycyrrhiza glabra plants).

[0041] The bevel gear set is driven by the self-locking hand-cranked wheel 8 to adjust the position of the rotating shaft 6 and change the angle and direction of the chromatography column 1 to meet the separation requirements of different substances. The design of the clamp 3 makes the assembly and disassembly of the chromatography column 1 simple and quick. The clamp 3 is locked and fixed by bolts A13 and B14. An outer sleeve 1201 and a sand core 1202 are arranged between the barrel 9 and the base 11 of the chromatography column 1 to form a filter element 12 to prevent leakage or contamination of the sample solution and protect the internal structure of the chromatography column 1. The drain pipe 16 and the drain valve 17 on the base 11 are convenient for draining residual liquid in the chromatography column 1 to reduce sample waste, and the drain valve 17 is used to control the drainage speed and flow rate.

[0042] When used specifically:

[0043] 1. Assembling the chromatography column

[0044] Prepare the various components of the chromatography column, including the barrel 9, barrel cover 10, bottom bracket 11, filter element 12 (outer sleeve 1201 and sand core 1202), hoop 3, etc. Install the sand core 1202 into the outer sleeve 1201 to assemble the filter element 12. Put the filter element 12 into the barrel 9, and the annular concave groove 1203 of the outer sleeve 1201 is connected with the inner wall of the barrel 9 and the bottom bracket 11. Install the bottom bracket 11 under the barrel 9, and the two are connected through the filter element 12. Use bolts A13 and bolts B14 to lock and fix the hoop 3 at the top of the barrel 9 and the bottom of the bottom bracket 11 respectively. Finally, cover the barrel cover 10, and the chromatography column 1 is assembled.

[0045] 2. Install the chromatography column to the bracket

[0046] Insert the lower ends of the two vertical poles 2 into the bearing seat 5 at the top of the bracket 4 respectively, sleeve the sleeve column 15 on the outer side of the vertical pole 2, and fix it with locking screws, connect the clamp 3 of the chromatography column 1 with the middle position of the two vertical poles 2 respectively, and fix it to the vertical pole 2 with locking screws on the outer side of the sleeve rod 302 of the clamp 3.

[0047] 3. Connect the drive mechanism

[0048] The bevel gear set in the installation box 7 is connected to the input end of one of the rotating shafts 6 by transmission, and a self-locking hand wheel 8 is installed on the outside of the installation box 7 so that it can drive the bevel gear set to rotate. The self-locking hand wheel 8 is rotated (or the motor is started). The hand wheel drives the bevel gear set to rotate, and then drives the rotating shaft 6 connected thereto to rotate. The rotation of the rotating shaft 6 enables the chromatography column 1 to adjust the angle and direction through the vertical pole 2 and the clamp 3; when in use, the chromatography column 1 is placed vertically to the horizontal plane.

[0049] 4. Chromatographic extraction and finalization

[0050] The sample solution to be separated is injected into the chromatography column 1 to start the chromatography process. The solution is filtered through the filter element 12 to remove impurities and then separated and extracted. After the chromatography is completed, the drain valve 17 on the bottom support 11 is opened, and the residual liquid in the chromatography column 1 is naturally discharged using the drain pipe 16 inclined on the bottom support 11.

[0051] 4. Chromatographic extraction and finalization

[0052] Rotate the self-locking hand wheel 8 (or start the motor) to adjust the chromatography column 1 to a horizontal state, remove the clamp 3 and the bottom support 11 on the chromatography column 1, and clean the components on the chromatography column 1; since it can be flipped to a horizontal position, it is very convenient to clean the silica gel or resin remaining on the upper part of the cylinder, and at the same time clean the residual substances in the sample solution to prevent them from being deposited on the inner wall of the cylinder and affecting the next elution; after cleaning, fill the filler required for chromatography and prepare for the next use.

[0053] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any minor modifications, equivalent substitutions and improvements made to the above embodiments based on the technical essence of the present invention should be included in the protection scope of the technical solution of the present invention.

Claims

1. A chromatography extraction device for glabridin, characterized in that: include: A chromatography column (1), wherein hoops (3) connecting the chromatography column (1) and two upright poles (2) are arranged at equal distances on the outer side of the chromatography column (1); A bracket (4), wherein two bearing seats (5) are provided on both sides of the top of the bracket (4), and a rotating shaft (6) rotatably connected to the two bearing seats (5) is fixedly sleeved outside the two uprights (2); An installation box (7) is provided inside the installation box (7), wherein a bevel gear set fixedly connected to the input end of one of the rotating shafts (6) is rotatably disposed therein, and a self-locking hand-cranked wheel (8) is provided outside the installation box (7) for driving the bevel gear set to move. By rotating the self-locking hand-cranked wheel (8), the bevel gear set and the rotating shaft (6) are driven to rotate, thereby adjusting the angle of the chromatography column (1).

2. A chromatography extraction device for glabridin according to claim 1, characterized in that: The chromatography column (1) comprises a barrel (9), a barrel cover (10) and a base (11); a filter element (12) is provided between the barrel (9) and the base (11); the clamp (3) on the barrel cover (10) is locked and fixed to the clamp (3) at the top of the barrel (9) by means of bolts A (13); and the clamp (3) on the base (11) is locked and fixed to the clamp (3) at the bottom of the barrel (9) by means of bolts B (14).

3. A chromatography extraction device for glabridin according to claim 2, characterized in that: The clamp (3) comprises two semicircular rings (301) which are fixed together by screws and embrace the outside of the chromatography column (1), a sleeve rod (302) which is located outside the two semicircular rings (301) and sleeved on the outer side of the vertical pole (2), and a mounting block (303) with holes which is located outside the semicircular rings (301) and is threadedly connected to the bolt A (13) or the bolt B (14). The sleeve rod (302) is fixed to the vertical pole (2) by locking screws.

4. A chromatography extraction device for glabridin according to claim 1, characterized in that: The rotating shaft (6) is fixedly connected to a sleeve column (15) sleeved on the outer side of the vertical pole (2); the sleeve column (15) is locked and fixed on the vertical pole (2) by means of a locking screw.

5. A chromatography extraction device for glabridin according to claim 2, characterized in that: The base support (11) is connected to a drainage pipe (16), and the drainage pipe (16) is provided with a drainage valve (17).

6. A chromatography extraction device for glabridin according to claim 2, characterized in that: The filter element (12) comprises an outer sleeve (1201) and a sand core (1202) arranged inside the outer sleeve (1201), and the upper and lower ends of the outer sleeve (1201) are respectively provided with annular concave grooves (1203) for inserting and positioning the cylinder body (9) and the base (11).

7. A chromatography extraction device for glabridin according to claim 1, characterized in that: The self-locking hand-cranked wheel (8) can be replaced by a motor and is used to control the rotation of the bevel gear set and the rotating shaft (6) so as to accurately adjust the angle of the chromatography column (1).

8. A chromatography extraction device for glabridin according to claim 2, characterized in that: The drainage pipe (16) on the base (11) is arranged obliquely with respect to the center line of the chromatography column (1).

9. A chromatography extraction device for glabridin according to claim 6, characterized in that: The sand core (1202) is a porous ceramic material used to improve filtering efficiency.

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