Production equipment of poly L-lactic acid particles

Abstract

The utility model relates to the technical field of lactic acid particle preparation, in particular to poly-L-lactic acid particle production equipment which comprises a stirring tank, a filtering barrel, a driving mechanism, a stirring shaft and a driving part, the filtering barrel is coaxially and rotatably connected in the stirring tank, the driving mechanism is used for driving the filtering barrel to rotate, the stirring shaft is coaxially and rotatably connected in the stirring tank, and the driving part is used for driving the stirring shaft to rotate. The stirring shaft is located below the filtering barrel, the rotating direction of the stirring shaft is opposite to the rotating direction of the filtering barrel, inclined stirring plates are arranged on the outer wall of the stirring shaft, the higher ends of the stirring plates face the upper portion of the stirring tank, the lower ends of the stirring plates face the bottom of the stirring tank, and the stirring plates are distributed in a circumferential array mode in the axial direction of the stirring shaft. The driving part is used for driving the stirring shaft to rotate, and through cooperation of the structures, the rotating directions of the filtering barrel and the stirring shaft are opposite, so that a solvent can be combined with a large number of poly-L-lactic acid particles in the filtering barrel.

Description

Technical Field

[0001] The utility model relates to the technical field of lactic acid microparticle preparation, in particular to a production device for poly (L-lactic acid) microparticles. Background Art

[0002] The Chinese patent with authorization announcement number CN2202114586U discloses a device for preparing injectable left-handed polylactic acid microparticles, which specifically discloses that it includes an outer shell, the inner wall of the outer shell is fixedly connected to a mixing barrel, the top surface of the mixing barrel is fixedly connected to a feeding box, the bottom surface of the feeding box is fixedly connected to a material guide pipe, the material guide pipe is arranged inside the outer shell, a connecting hole is penetrated through the outer wall of the material guide pipe, a rotating shaft is rotatably connected through the bottom surface of the inner wall of the mixing barrel, a reduction motor is fixedly installed on the bottom surface of the outer shell, the output shaft end of the reduction motor is fixedly connected to the bottom end of the rotating shaft, the outer wall of the rotating shaft is fixedly connected to a traction rod, one end of the traction rod is fixedly connected to a stirring plate, and the bottom surface of the inner wall of the mixing barrel is fixedly connected to a guide plate.

[0003] Although the above patent can make L-polylactic acid and solvent have better contact reaction, less prone to accumulation and increase the mixing reaction speed, due to the limited capacity of the guide tube, it cannot accommodate a large number of L-polylactic acid particles, resulting in inconvenience for L-polylactic acid particles that need to be dissolved in large quantities. Therefore, there is an urgent need for a production equipment for poly (L-lactic acid) microparticles that can dissolve and prepare a large number of L-polylactic acid particles and solvents to improve the dissolution efficiency. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a production device for poly (L-lactic acid) microparticles, which can dissolve and prepare a large number of left-handed poly (L-lactic acid) particles with solvents, improve the dissolution efficiency, and thus improve the production efficiency of microspheres.

[0005] In order to solve the above technical problems, the technical solution adopted by the utility model is: a production device for poly (L-lactic acid) microparticles, comprising:

[0006] A stirring tank; a first opening is provided at the upper portion of the stirring tank, a support column is provided at the lower portion of the stirring tank, the two support columns are symmetrical about the axis of the stirring tank, and a solvent tube is provided on the side wall of the stirring tank;

[0007] A filter barrel, wherein a second opening is provided on the upper portion of the filter barrel, filter holes are provided around the filter barrel, and the filter barrel is coaxially rotatably connected to the stirring tank;

[0008] A driving mechanism, which is used to drive the filter barrel to rotate;

[0009] A stirring shaft, the stirring shaft is coaxially rotatably connected to the stirring tank, the stirring shaft is located below the filter barrel, the direction of rotation of the stirring shaft is opposite to the direction of rotation of the filter barrel, an inclined stirring plate is arranged on the outer wall of the stirring shaft, the higher end of the stirring plate faces the upper part of the stirring tank, and the lower end of the stirring plate faces the bottom of the stirring tank, and a plurality of stirring plates are distributed in a circular array along the axial direction of the stirring shaft;

[0010] A driving member is used to drive the stirring shaft to rotate.

[0011] Furthermore, the driving mechanism includes a circular connecting member, a first connecting plate, a circular fixing plate, a second connecting plate and a first driving motor, one end of the first connecting plate is connected to the upper edge of the first opening, the first connecting plate is parallel to the axial direction of the stirring shaft, the circular fixing plate is connected to the upper part of the first connecting plate, the first driving motor is connected to the lower part of the circular fixing plate, the second connecting plate is connected to the second opening, one end of the second connecting plate is perpendicular and compared to the axial direction of the stirring tank, the outer circumference of the circular connecting member is connected to the other end of the second connecting plate, and the output shaft of the driving motor is drivingly connected to the circular connecting member.

[0012] Furthermore, the driving member is a second driving motor, which is connected to the bottom of the stirring tank, and the output end of the second driving motor is transmission-connected to the stirring shaft, and the rotation direction of the second driving motor is opposite to that of the first driving motor.

[0013] Furthermore, a discharge pipe is provided on the bottom side wall of the mixing tank, and a discharge valve is provided on the discharge pipe.

[0014] Furthermore, the angle between the stirring plate and the horizontal is 30-45°.

[0015] Furthermore, a stirring rod is provided on the lower side wall of the stirring shaft, and two stirring rods are arranged in a circular array along the axial direction of the stirring shaft. A scraper is provided at one end of the stirring rod close to the inner wall of the stirring tank, and the scraper is perpendicular to the stirring rod.

[0016] Furthermore, the upper part of the stirring shaft is connected to the bottom of the filter barrel through a bearing seat, and a transverse plate is provided on the upper outer wall of the stirring shaft, and the scraper is connected to the stirring shaft through the transverse plate.

[0017] The beneficial effect of the utility model is that, compared with the prior art, it can improve the dissolution efficiency by combining a large number of L-polylactic acid particles, thereby improving the production efficiency of microspheres. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of a production device for poly (L-lactic acid) microparticles according to a specific embodiment of the utility model;

[0019] Figure 2 This is an internal structure diagram of a production device for poly (L-lactic acid) microparticles according to a specific embodiment of the utility model;

[0020] Figure 3 It is a side view of a production device for poly (L-lactic acid) microparticles according to a specific embodiment of the utility model;

[0021] Figure 4 for Figure 3 A-direction cross-sectional view.

[0022] Description of symbols

[0023] 1. stirring tank; 11. first opening; 12. support column; 13. solvent pipe; 14. discharge pipe; 141. discharge valve;

[0024] 2. filter barrel; 21. second opening; 22. filter hole;

[0025] 3. Driving mechanism; 31. Circular connecting member; 32. First connecting plate; 33. Circular fixing plate; 34. Second connecting plate; 35. First driving motor;

[0026] 4. stirring shaft; 41. stirring plate; 42. stirring rod; 43. scraper;

[0027] 5. Second drive motor;

[0028] 6. Bearing seat;

[0029] 7. Horizontal board. DETAILED DESCRIPTION

[0030] In order to explain the technical content, achieved objectives and effects of the present invention in detail, the following is an explanation in conjunction with the implementation modes and the accompanying drawings.

[0031] Please refer to Figures 1 to 4 , a production device for poly (L-lactic acid) microparticles, comprising:

[0032] A stirring tank 1; a first opening 11 is provided at the upper portion of the stirring tank 1, a support column 12 is provided at the lower portion of the stirring tank 1, two support columns 12 are symmetrical about the axis of the stirring tank 1, and a solvent tube 13 is provided on the side wall of the stirring tank 1;

[0033] A filter barrel 2, wherein a second opening 21 is provided on the upper portion of the filter barrel 2, filter holes 22 are provided around the filter barrel 2, and the filter barrel 2 is coaxially rotatably connected to the stirring tank 1;

[0034] A driving mechanism 3, which is used to drive the filter barrel 2 to rotate;

[0035] A stirring shaft 4 is coaxially rotatably connected to the stirring tank 1. The stirring shaft 4 is located below the filter barrel 2. The direction of rotation of the stirring shaft 4 is opposite to the direction of rotation of the filter. An inclined stirring plate 41 is provided on the outer wall of the stirring shaft 4. The higher end of the stirring plate 41 faces the upper part of the stirring tank 1, and the lower end of the stirring plate 41 faces the bottom of the stirring tank 1. A plurality of stirring plates 41 are distributed in a circular array along the axial direction of the stirring shaft 4.

[0036] A driving member is used to drive the stirring shaft 4 to rotate.

[0037] In the above embodiment, L-polylactic acid is poured into the filter barrel 2 and precipitated at the bottom of the filter barrel 2. Then, the solvent is injected into the stirring tank 1 through the solvent tube 13 so that the solvent is higher than the bottom of the filter barrel 2. Then, the driving mechanism 3 and the driving member are turned on, the filter barrel 2 rotates forward, and the stirring shaft 4 rotates reversely. The L-polylactic acid particles are thrown out from the filter holes 22 by the centrifugal force of the filter barrel 2 and combine with the solvent. The solvent enters the filter barrel 2 and combines with the L-polylactic acid particles, thereby better combining the L-polylactic acid particles. Since the capacity of the filter barrel 2 is greater than the capacity of the feed pipe, compared with the prior art, it can improve the dissolution efficiency for the combination of large quantities of L-polylactic acid particles, thereby improving the production efficiency of microspheres.

[0038] As an optional embodiment, the driving mechanism 3 includes a circular connecting member 31, a first connecting plate 32, a circular fixing plate 33, a second connecting plate 34 and a first driving motor 35, one end of the first connecting plate 32 is connected to the upper edge of the first opening 11, the first connecting plate 32 is parallel to the axial direction of the stirring shaft 4, the circular fixing plate 33 is connected to the upper part of the first connecting plate 32, the first driving motor 35 is connected to the lower part of the circular fixing plate 33, the second connecting plate 34 is connected to the second opening 21, one end of the second connecting plate 34 is perpendicular and compared to the axial direction of the stirring tank 1, the outer circumference of the circular connecting member 31 is connected to the other end of the second connecting plate 34, and the output shaft of the driving motor is transmission-connected to the circular connecting member 31.

[0039] In the above embodiment, the driving motor is fixed by the circular fixing plate 33 and then connected to the filter barrel 2 through the circular connecting member 31. Then, the output shaft of the driving motor is transmission-connected to the circular connecting member 31, thereby driving the filter barrel 2 to rotate.

[0040] As an optional embodiment, the driving member is a second driving motor 5, the second driving motor 5 is connected to the bottom of the stirring tank 1, the output end of the second driving motor 5 is transmission-connected to the stirring shaft 4, and the rotation direction of the second driving motor 5 is opposite to that of the first driving motor 35.

[0041] In the above embodiment, the stirring shaft 4 is driven to rotate by the second driving motor 5, and the first driving motor 35 drives the filter barrel 2 to rotate, so that the filter barrel 2 rotates in the opposite direction to the stirring shaft 4, generating a stronger shear force, thereby preparing emulsified microspheres.

[0042] As an optional implementation, a discharge pipe 14 is provided on the bottom side wall of the stirring tank, and a discharge valve 141 is provided on the discharge pipe 14 .

[0043] In the above embodiment, when stirring and shearing are being performed in the stirring tank 1 , the discharge valve 141 is closed, and when the stirring and shearing are completed, the discharge valve 141 is opened, and the material is discharged from the discharge pipe 141 .

[0044] As an optional embodiment, the angle between the stirring plate 41 and the horizontal is 30-45°.

[0045] As an optional embodiment, a stirring rod 42 is provided on the lower side wall of the stirring shaft 4, and two stirring rods 42 are arranged in a circular array along the axial direction of the stirring shaft 4. A scraper 43 is provided at one end of the stirring rod 42 close to the inner wall of the stirring tank 1, and the scraper 43 is perpendicular to the stirring rod 42.

[0046] In the above embodiment, a stirring rod 42 and a scraper 43 are provided on the lower side wall of the stirring shaft 4, so that during the stirring process, the scraper 43 can scrape off the material on the inner wall of the stirring tank 1, and the stirring rod 42 can stir the material sunk to the bottom of the stirring tube, so that the solvent can be better mixed with the left-handed polylactic acid, thereby improving the efficiency of preparing microspheres.

[0047] As an optional embodiment, the upper part of the stirring shaft 4 is connected to the bottom of the filter barrel 2 through the bearing seat 6, the upper outer wall of the stirring shaft 4 is provided with a transverse plate 7, and the scraper 43 is connected to the stirring shaft 4 through the transverse plate 7.

[0048] In the above embodiment, the stirring shaft 4 , the filter barrel 2 , and the scraper 43 are integrally connected, so that the filter barrel 2 , the stirring shaft 4 , and the scraper 43 can operate more stably in the stirring tank 1 .

[0049] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent transformations made using the contents of the specification and drawings of the present invention, or directly or indirectly applied in the relevant technical field, are also included in the patent protection scope of the present invention.

Claims

1. A production device for poly (L-lactic acid) microparticles, characterized in that: include: A stirring tank; a first opening is provided at the upper portion of the stirring tank, a support column is provided at the lower portion of the stirring tank, the two support columns are symmetrical about the axis of the stirring tank, and a solvent tube is provided on the side wall of the stirring tank; A filter barrel, wherein a second opening is provided on the upper portion of the filter barrel, filter holes are provided around the filter barrel, and the filter barrel is coaxially rotatably connected to the stirring tank; A driving mechanism, which is used to drive the filter barrel to rotate; A stirring shaft, the stirring shaft is coaxially rotatably connected to the stirring tank, the stirring shaft is located below the filter barrel, the direction of rotation of the stirring shaft is opposite to the direction of rotation of the filter barrel, an inclined stirring plate is arranged on the outer wall of the stirring shaft, the higher end of the stirring plate faces the upper part of the stirring tank, and the lower end of the stirring plate faces the bottom of the stirring tank, and a plurality of stirring plates are distributed in a circular array along the axial direction of the stirring shaft; A driving member is used to drive the stirring shaft to rotate.

2. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: The driving mechanism includes a circular connecting member, a first connecting plate, a circular fixing plate, a second connecting plate and a first driving motor, one end of the first connecting plate is connected to the upper edge of the first opening, the first connecting plate is parallel to the axial direction of the stirring shaft, the circular fixing plate is connected to the upper part of the first connecting plate, the first driving motor is connected to the lower part of the circular fixing plate, the second connecting plate is connected to the second opening, one end of the second connecting plate is perpendicular and compared to the axial direction of the stirring tank, the outer circumference of the circular connecting member is connected to the other end of the second connecting plate, and the output shaft of the driving motor is drivingly connected to the circular connecting member.

3. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: The driving member is a second driving motor, which is connected to the bottom of the stirring tank. The output end of the second driving motor is transmission-connected to the stirring shaft, and the rotation direction of the second driving motor is opposite to that of the first driving motor.

4. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: A discharge pipe is arranged on the bottom side wall of the mixing tank, and a discharge valve is arranged on the discharge pipe.

5. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: The angle between the stirring plate and the horizontal is 30-45°.

6. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: A stirring rod is arranged on the lower side wall of the stirring shaft. The two stirring rods are arranged in a circular array along the axial direction of the stirring shaft. A scraper is arranged at one end of the stirring rod close to the inner wall of the stirring tank, and the scraper is perpendicular to the stirring rod.

7. The production equipment of poly (L-lactic acid) microparticles according to claim 1, characterized in that: The upper part of the stirring shaft is connected with the bottom of the filter barrel through a bearing seat, and a transverse plate is arranged on the upper outer wall of the stirring shaft, and the scraper is connected with the stirring shaft through the transverse plate.

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