Pen for liquid collection and detection

Abstract

The utility model provides a pen for liquid collection and detection, which is a small and portable one-step detection pen for liquid sample detection, particularly blood sample detection, sampling and detection do not need to be carried out separately, and the shape of the pen and the detection mode of a pen sleeve form can be accepted and adapted by users more easily. The pen for liquid collection and detection comprises a pen body and a pen cap, the pen body comprises a sampling end, a transition end and a detection end, the transition end is in fluid communication with the sampling end and the detection end, and the detection end comprises an air hole and contains detection test paper; a capillary channel is arranged in the sampling end, the bottom end of the capillary channel is located at the top end of the sampling end, and the top end of the capillary channel is located in the middle or bottom of the sampling end; after the pen body is inserted into the pen cap, a compressible air chamber is formed between the pen body and the pen cap, and compressed air is exhausted through the air hole.

Description

Technical Field

[0001] The utility model relates to the field of in vitro diagnosis, in particular to a pen for collecting and detecting liquid. Background Art

[0002] The technology of using the principle of immune binding reaction to detect whether the analyte exists in the sample is widely used in various fields, including detecting the analyte in saliva, blood, urine, serum, sweat, feces, wastewater and other samples to monitor the health of humans, animals, plants, and the environment. The fundamental principle of this detection technology is based on the specific binding performance between immune molecules, such as antibodies and antigens, haptens / antibodies, biotin and anti-biotin, etc.

[0003] Saliva and urine are used as samples for disease detection. Since sampling is non-invasive and convenient, they are widely used in epidemic virus detection, drug abuse screening, etc.

[0004] Using blood as a sample for disease detection and applying immunochromatography technology, a variety of different diagnostic reagents have been developed and applied in different disease detection fields, such as: detection of tumor markers, early prediction of cardiovascular diseases, screening and detection of infectious diseases, etc. Blood is a more commonly used sample source, especially fingertip blood, because it is minimally invasive and rapid, and has been widely adopted by various platforms.

[0005] In the prior art, using the above samples for home self-testing generally requires sampling and testing to be performed separately, which cannot meet the user's demand for testing convenience. Summary of the invention

[0006] In order to solve the problems of the prior art, the utility model provides a pen for collecting and detecting liquid, comprising a pen body and a pen cover; the pen body comprises a sampling end, a transition end and a detection end, the transition end fluid connects the sampling end and the detection end, the detection end comprises an air hole and accommodates a detection test paper; a capillary channel is arranged inside the sampling end, the bottom end of the capillary channel is located at the top end of the sampling end, and the top end of the capillary channel is located in the middle or bottom of the sampling end; after the pen body is inserted into the pen cover, a compressible air chamber is formed between the pen body and the pen cover, and the compressed gas is discharged through the air hole.

[0007] Furthermore, the top of the capillary channel is located in the middle of the sampling end, a buffer cavity is provided in the sampling end, a groove is provided in the buffer cavity, and the groove is connected to the top of the capillary channel.

[0008] Furthermore, the pen cover is provided with a storage chamber, in which a buffer solution is sealed.

[0009] Furthermore, the top of the sampling end is a flat-top cone.

[0010] Particularly, the sampling end comprises a protruding platform, on which a through channel communicating with the capillary channel fluid is disposed, the junction of the through channel and the capillary channel is located in the middle of the sampling end, and the top of the capillary channel coincides with the junction.

[0011] Furthermore, the pen cover comprises a first chamber, a second chamber and a third chamber which are connected in series, the inner diameter of the second chamber is larger than the inner diameter of the first chamber, and the inner diameter of the first chamber is larger than the inner diameter of the third chamber.

[0012] Furthermore, the third chamber transitions to the first chamber and the inner diameter gradually decreases to be in a funnel shape.

[0013] Particularly, the sampling end is in the shape of an inverted cone, and the maximum diameter of the inverted cone is greater than the minimum inner diameter of the pen cover.

[0014] Particularly, a buffer pad is provided at the transition end.

[0015] Preferably, the diameter of the capillary channel is between 0.1-1.7 mm.

[0016] The beneficial effects of the utility model include: 1. Providing a compact and portable one-step detection pen for liquid sample detection, especially blood sample detection. Sampling and detection do not need to be performed separately, and the shape of the pen and the detection method in the form of a pen cover are easier for users to accept and adapt to. 2. A buffer cavity is set in the middle of the sampling end and connected to the top of the capillary channel, or a through channel is set on the protruding platform and connected to the top of the capillary channel, which provides time and space for the full mixing of the sample to be tested and the buffer solution. 3. The first chamber, the second chamber and the third chamber are set in the pen cover to provide guarantee for the quantification of the sample to be tested. 4. The sampling end is inverted cone shape to ensure that the flow of the sample to be tested is not hindered. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 One of the exploded views of the liquid collection and detection pen of the present invention.

[0018] Figure 2 One of the cross-sectional views of the pen cover for liquid collection and detection of the present invention.

[0019] Figure 3 One of the partial cross-sectional views of the liquid collection and detection pen of the present invention.

[0020] Figure 4 The second partial cross-sectional view of the liquid collection and detection pen of the present invention.

[0021] Figure 5 The third partial cross-sectional view of the liquid collection and detection pen of the present invention.

[0022] Figure 6 A cross-sectional view of the detection end of the liquid collection and detection pen of the present invention.

[0023] Figure 7The second cross-sectional view of the pen cover for liquid collection and detection of the present invention.

[0024] Figure 8 One of the use processes of the liquid collection and detection pen of the present invention.

[0025] Fig. 9 The second use process of the liquid collection and detection pen of the present invention.

[0026] Pen body 1; pen cover 2; backflow chamber 2111; chamber outlet 2115; backflow chamber starting end 2101; backflow chamber ending end 2102; compressible air chamber 110; first chamber 2111; second chamber 2112; third chamber 2113; sealing ring 1132; sampling end 11; detection end 12; transition end 113; sampling end top 1111; sampling end side wall 1112; capillary channel 112; capillary channel inlet 1121; capillary channel outlet 1125; protruding platform 1131 ; Sealing contact surface 2110; Storage chamber 221; Storage chamber bottom surface 2212; Storage chamber entrance 2211; Sealing sheet 2216; First end 121 of the body; Test paper cavity 120; Test paper holder 1201; Second end 122 of the body; Through channel 114; Through channel entrance 1141; Buffer cavity 115; One of the convex strips 214; Two of the convex strips 226; One of the notches 227; Two of the notches 213; Insert plate 212; Surrounding wing 224; Slit 225; Buffer zone 20; Buffer pad 201. Implementation Example 1

[0027] like Figure 1 As shown, a liquid collection and detection pen includes a pen cover 2 and a pen body 1. When in use, the pen body is used to obtain a sample to be tested, and then the pen body is inserted into the pen cover, so that the pen body and the pen cover cooperate with each other and gradually close. In this process, the pen cover and the pen body form a compressible air chamber, and the compressible air chamber causes the sample to be tested to flow in the opposite direction of the movement direction of the pen body during the closing process. The sample to be tested is received by the test paper, and the test can be completed after waiting for a certain period of time. The test result can be observed through the pen body. The operation is very simple and easy to understand.

[0028] like Figure 2As shown in (a), the pen cap includes a reflux chamber 2111 and a chamber outlet 2115. The reflux chamber includes a reflux chamber starting end 2101 and a reflux chamber ending end 2102. The reflux chamber is used to help form a compressible air chamber 110, and is the key to promoting the flow of the sample to be tested from the pen cap to the pen body. The length of the reflux chamber can be designed differently according to the required amount of liquid to be tested, that is to say, the reflux chamber is also the key to the quantification of the sample to be tested. In a further case, the pen cap has a larger inner diameter and a smaller inner diameter. Specifically, the pen cap includes a reflux chamber and a non-reflux chamber. The reflux chamber can correspond to a larger inner diameter or a smaller inner diameter. The meaning of the inner diameter here does not just correspond to a circular cross-section. If the cross-section of the pen cap is rectangular or polygonal, the inner diagonal corresponds to the diameter mentioned above. This concept applies to the entire text.

[0029] The pen body includes a sampling end 11, a detection end 12 and a transition end 113. The transition end fluid connects the sampling end and the detection end. The transition end can be a blank space between the sampling end and the detection end, or an overlapping structure connecting the sampling end and the detection end, such as an overlapping part of the sampling end and the detection end formed by a threaded connection, a snap connection, or a plug-in connection. The sampling end cooperates with the pen cover, and the sampling end will enter the pen cover, such as Figure 8 or the pen cover also includes a storage chamber sealed with a buffer solution with a sealing sheet. When the pen body is inserted into the pen cover, the sampling end first abuts against the sealing sheet in the pen cover, and then punctures the sealing sheet to enter the storage chamber, such as Fig. 9 As shown. Figure 3 (a)(b) are cross-sectional views of the sampling end and part of the transition end. The sampling end includes a sampling end top 1111 and a capillary channel 112. The sampling end top is used to contact and collect the test sample. The capillary channel is a hollow channel that terminates at the transition end. The capillary channel has a capillary channel inlet 1121 and a capillary channel outlet 1125 at the sampling end. The capillary channel inlet is the bottom of the capillary channel and is used to first contact the sample to be tested. The capillary channel outlet is located at the bottom of the sampling end and is the top of the capillary channel. It is used to define the amount of the liquid sample to be tested. The sample to be tested flows into the capillary channel inlet and stops flowing at the top of the capillary channel. The amount of the sample to be tested from the capillary channel inlet to the top of the capillary channel is the amount of the sample to be tested that needs to be obtained. The capillary channel inlet is located at any position of the sampling end, such as Figure 3 As shown in (a), the inlet of the capillary channel is located at the top of the sampling end. Figure 5 , which is a cross-sectional view of the sampling end and part of the transition end, wherein the capillary channel inlet is located at the side wall 1112 of the sampling end. In another case, the sampling end further includes a protruding platform 1131, such as Figure 3(b) shows that the capillary channel entrance is located on the protruding platform. In a preferred case, the diameter of the capillary channel is between 0.1-2mm, which is calculated based on the raw material properties of the capillary channel, the properties of the liquid sample and the required sample size. The basic raw material of the capillary channel can be the same as the other parts of the sampling end, except that a hydrophilic coating is applied to the capillary channel; or the raw material of the capillary channel is different from the other parts of the sampling end, such as glass, quartz, or polymers that can be used to make capillaries. More preferably, the diameter of the capillary channel is between 0.1-1.7mm, which can be calculated based on the raw material properties of the capillary channel, the properties of the blood sample and the required sample size.

[0030] like Figure 3 As shown, the sampling end or the transition end is provided with a sealing ring 1132, and the sealing ring is located on the outer wall of the sampling end away from the top of the sampling end, so that when the sealing ring is sleeved on the sampling end, the diameter of the sealing ring is greater than the outer diameter of the sampling end and other positions of the transition end, or the sealing ring is located on the outer wall of the transition end away from the sampling end, so that when the sealing ring is sleeved on the transition end, the diameter of the sealing ring is greater than the diameter of the transition end and other positions of the sampling end. The diameter of the sealing ring is greater than the inner diameter of the backflow chamber. Since the sealing ring is an elastic component, the sealing ring is squeezed by the backflow chamber when entering the backflow chamber and produces elastic deformation. The elastic deformation produces a force that reacts on the backflow chamber, thereby forming a sealing contact surface 2110 between the sampling end of the pen body and the backflow chamber of the pen cover. The sealing contact surface forms a compressible air chamber 110 between the sampling end and the pen cover, or a compressible air chamber is formed between the transition end, the sampling end, and the pen cover. Of course, in addition to the sealing ring, other similar methods can also be used to realize the compressible air chamber between the pen body and the pen cover.

[0031] In the first case, if Figure 2 As shown in (b), the pen cover includes a first chamber 2111 and a third chamber 2113. The inner diameter of the first chamber is larger than the inner diameter of the third chamber. The first chamber is a reflux chamber, and the third chamber is a non-reflux chamber. The inner diameter of the first chamber is equivalent to the diameter of the sealing ring provided on the sampling end, so that when the pen body is inserted into the pen cover, the sealing ring can contact the starting end of the reflux chamber and move in the first chamber until it contacts the terminal end of the reflux chamber. During the movement of the sealing ring in the first chamber, there is always a sealing contact surface between the sealing ring and the first chamber, and a compressible air chamber is formed between the pen body and the pen cover. The third chamber transitions to the first chamber, and the diameter of the third chamber gradually decreases in the direction away from the first chamber and presents a funnel shape. The third chamber can limit the end point of the movement of the sampling end and prevent the pen body from continuing to move. The end point of the movement of the sampling end is limited to the terminal end of the reflux chamber, thereby providing a guarantee for the quantitative measurement of the sample to be tested. In the second case, as Figure 2As shown in (c), the pen cap includes a first chamber 2111 and a second chamber 2112, the inner diameter of the second chamber is larger than the inner diameter of the first chamber, the second chamber is a non-reflux chamber, the first chamber is a reflux chamber, and the inner diameter of the second chamber is larger than the sealing ring 1132, so that when the pen body is inserted into the pen cap, the sampling end first passes through the second chamber without any contact with the inner wall of the second chamber. The inner diameter of the first chamber is smaller than the inner diameter of the second chamber, and is equivalent to the diameter of the sealing ring, so that when the pen body is inserted into the pen cap, the sealing ring first passes through the second chamber and then enters the first chamber, and contacts the starting end of the reflux chamber and moves in the first chamber until it contacts the ending end of the reflux chamber. During the movement of the sealing ring in the first chamber, there is always a sealing contact surface between the sealing ring and the first chamber, and a compressible air chamber is formed between the pen body and the pen cap. In the third case, as Figure 2 As shown in (d), the pen cover includes a first chamber 2111, a second chamber 2112 and a third chamber 2113 connected in series, the first chamber is a counterflow chamber, the second chamber and the third chamber are non-counterflow chambers, the inner diameter of the second chamber is larger than the inner diameter of the first chamber and larger than the inner diameter of the third chamber. The third chamber transitions to the first chamber, which can limit the end point of the sampling end movement and prevent the pen body from continuing to move.

[0032] like Figure 6 As shown, the detection end includes a first end 121 of the body, a test paper cavity 120 and a second end 122 of the body, wherein the first end of the body is positioned and connected with the sampling end through a transition end, and the test paper cavity can accommodate the test paper, or further the test paper is fixed on the test paper holder 1201 of the test paper cavity. The sample receiving area of ​​the test paper corresponds to the first end of the body of the detection end and is in fluid communication with the transition end and the sampling end. The sample receiving area of ​​the test paper is in the transition end so that it can receive the sample from the sampling end; or a buffer pad is provided in the transition end, the sample receiving area of ​​the test paper abuts against the buffer pad, the sample to be tested has an impact force under the action of the compressible air chamber and impacts the buffer pad and then transitions from the buffer pad to the sample receiving area through capillary action; or a buffer zone is provided between the sample receiving area and the transition end of the test paper, the sample receiving area and the transition end of the test paper are separated by the buffer zone, the sample to be tested has an impact force under the action of the compressible air chamber 110, passes through the buffer zone first and then impacts the sample receiving area; or further, as Figure 8 As shown, a buffer pad 201 is provided in the buffer zone 20, and the sample receiving area of ​​the test paper abuts against the buffer pad. The sample to be tested has an impact force under the action of the compressible air chamber, first passes through the transition end and impacts the buffer pad, and then transitions from the buffer pad to the sample receiving area through capillary action. The second end of the body of the detection end includes an air hole, which allows gas to pass through, so that the pen body is connected to the air at a certain position, and the diameter of the air hole is within 2mm, so as to ensure that during the detection process, when the pen body is inserted into the pen cover, the compressed gas in the compressible air chamber is discharged from the air hole to maintain the balance of the compressible air chamber, so that the user can complete the operation effortlessly. Example 2

[0033] The pen cover also includes a storage chamber 221 sealed with a buffer solution by a sealing sheet. Figure 7 As shown, the storage chamber includes a storage chamber bottom surface 2212, a buffer is enclosed in the storage chamber, and the storage chamber inlet 2211 is sealed by a sealing sheet 2216. Generally, the storage chamber is connected to the pen cover by a thread, or as shown in FIG. Figure 7 As shown in (b), the storage chamber is connected to the pen cover by a snap, or as Figure 7 As shown in (a), the storage chamber is connected to the pen cover by interference fit. Figure 7 As shown in (b), the pen cap is provided with one convex strip 214 or the storage chamber is provided with the second convex strip 226, and the storage chamber is provided with one concave groove 227 or the pen cap is provided with the second concave groove 213, or the above four exist at the same time, and the convex strip and the concave groove are mutually engaged. Figure 7 As shown in (a), the pen cover includes an insert plate 212, and the storage chamber includes a surrounding wing 224 and a slit 225. The width of the slit is equivalent to the thickness of the insert plate. After the insert plate is inserted into the slit and moves relative to the storage chamber for a certain distance, the insert plate stays in the slit due to the pressure squeezed by the surrounding wing and the outer wall of the storage chamber, and the pen cover is assembled. The thickness of the far end of the insert plate can be less than the thickness of the near end of the insert plate, so that a buffering effect can be given to the squeezing effect between the insert plate and the slit.

[0034] In order to allow the sampling end to puncture the sealing sheet while obtaining the sample, the top of the sampling end is a flat cone. Figure 4 (a) and (b) show the cross-sectional views of the sampling end and part of the transition end. Figure 4 The sampling end in (a) further includes a through channel 114 in communication with the capillary channel fluid, the through channel inlet 1141 is arranged on the protruding platform, the through channel and the capillary channel meet and communicate at the middle part of the capillary channel, the meeting point of the through channel and the capillary channel becomes the top of the capillary channel and is located in the middle of the sampling end, the meeting point of the through channel and the capillary channel coincides with the top of the capillary channel, and the capillary channel outlet becomes the termination end of the through channel. On the one hand, the through channel makes the top of the capillary channel at the meeting point of the through channel and the capillary channel, that is, located in the middle of the sampling end, and on the other hand, the through channel provides more movement paths for the sample to be tested, so as to achieve the purpose of further mixing the sample to be tested with the buffer.

[0035] In a further embodiment, Figure 4As shown in (b), a buffer chamber 115 is provided at the junction of the capillary channel and the through channel, and the buffer chamber is located in the sampling end. Since the buffer chamber is relatively large in volume, it is more conducive to the full mixing of the sample to be tested and the buffer solution. Furthermore, the buffer chamber includes a groove (not shown) for guiding the flow of the sample, and the groove connects the top of the capillary channel and the terminal end of the through channel, so as to help the mixed sample flow along a predetermined track and then be received by the test paper. In other embodiments, even if there is no through channel, the middle part of the capillary channel may include a buffer chamber, and the buffer chamber further includes a groove. Example 3

[0036] When the test is completed, the entrance of the capillary channel is far away from the bottom surface of the storage chamber. Because the entrance of the capillary channel is the entrance of the sample to be tested, such a design can provide a wide space for the liquid in the storage chamber to flow upward through the capillary channel, and prevent the capillary channel from being too close to the bottom surface of the storage chamber and hindering the flow of the sample to be tested to a certain extent. The sampling end is designed to be an inverted cone shape with a diameter gradually decreasing from the side close to the transition end toward the top of the sampling end, that is, the maximum diameter of the sampling end close to the transition end is greater than the minimum diameter of the pen cover, or the maximum diameter of the inverted cone is greater than the inner diameter of the chamber outlet, so as to ensure that the chamber opening can limit the sampling end to a certain height, and the entrance of the capillary channel is far away from the bottom surface of the storage chamber, ensuring that the flow of the sample to be tested is not hindered.

[0037] The terms “first”, “second” and “third” in the present invention are for the purpose of explanation and are only used to distinguish names, and do not represent quantity or order.

[0038] The above specific implementation modes are used to explain the present invention rather than to limit the present invention. Any modification and change made to the present invention within the spirit of the present invention and the protection scope of the claims shall fall within the protection scope of the present invention.

Claims

1. A pen for collecting and detecting liquid, characterized in that: The invention comprises a pen body and a pen cover; the pen body comprises a sampling end, a transition end and a detection end, the transition end fluid is connected with the sampling end and the detection end, the detection end comprises an air hole and contains a detection test paper; a capillary channel is arranged inside the sampling end, the bottom end of the capillary channel is located at the top end of the sampling end, and the top end of the capillary channel is located at the middle or bottom of the sampling end; after the pen body is inserted into the pen cover, a compressible air chamber is formed between the pen body and the pen cover, and the compressed gas is discharged through the air hole.

2. A liquid collection and detection pen according to claim 1, characterized in that: The top of the capillary channel is located in the middle of the sampling end. A buffer cavity is provided in the sampling end. A groove is provided in the buffer cavity. The groove is connected to the top of the capillary channel.

3. A liquid collection and detection pen according to claim 1, characterized in that: The pen cover is also provided with a storage chamber, in which a buffer solution is sealed.

4. A liquid collection and detection pen according to claim 3, characterized in that: The top end of the sampling end is in a flat cone shape.

5. A liquid collection and detection pen according to claim 3, characterized in that: The sampling end comprises a protruding platform, on which a through channel communicating with the capillary channel fluid is disposed, the through channel and the capillary channel meet at the middle of the sampling end, and the top of the capillary channel coincides with the meet.

6. A liquid collection and detection pen according to any one of claims 1 to 5, characterized in that: The pen cover comprises a first chamber, a second chamber and a third chamber which are connected in series. The inner diameter of the second chamber is larger than the inner diameter of the first chamber, and the inner diameter of the first chamber is larger than the inner diameter of the third chamber.

7. A liquid collection and detection pen according to claim 6, characterized in that: The third chamber transitions to the first chamber and its inner diameter gradually decreases to form a funnel shape.

8. A liquid collection and detection pen according to any one of claims 1 to 5, characterized in that: The sampling end is in the shape of an inverted cone, and the maximum diameter of the inverted cone is greater than the minimum inner diameter of the pen cover.

9. A liquid collection and detection pen according to any one of claims 1 to 5, characterized in that: The transition end is provided with a buffer pad.

10. A liquid collection and detection pen according to any one of claims 1 to 5, characterized in that: The diameter of the capillary channel is between 0.1 and 1.7 mm.

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