One-twelve-station parallel reaction instrument

Abstract

The utility model relates to the technical field of reaction instruments for biological pharmacy and the like, and discloses a twelve-station parallel reaction instrument which comprises a lower cooling disc, an upper cooling disc is attached to the upper surface of the lower cooling disc, a plurality of single air exhaust holes are fixedly connected to the upper surface of the upper cooling disc, a centralized air supply hole is fixedly connected to the inner sides of the single air exhaust holes, and the centralized air supply hole is fixedly connected to the lower surface of the lower cooling disc. Placing grooves are formed in the lower cooling disc and the upper cooling disc in a penetrating mode, holding handles which are in bilateral symmetry are fixedly connected to one side of the outer wall of the lower cooling disc, a first liquid inlet pipe is fixedly connected to one side of the outer wall of the lower cooling disc, and a first liquid outlet pipe is fixedly connected to the adjacent side of the first liquid inlet pipe. According to the rapid placing and installing device, the holding handle is held by hand to enable the positioning groove in the lower cooling disc to be clamped on the triangular positioning block, then the rapid placing and installing effect is achieved, meanwhile, through the cooperation of the first installing bolt and the second installing bolt, the effect of being convenient to disassemble and place is achieved, and then the practicability of the instrument is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of reaction instruments such as biopharmaceuticals, and in particular to a twelve-station parallel reaction instrument. Background Art

[0002] A parallel reactor is a device used in chemical laboratories to perform multiple chemical reactions simultaneously. It usually consists of a parallel reactor with twelve reaction sites, each of which can independently control the temperature, stirring speed and other reaction conditions. This parallel reactor is usually used for high-throughput experiments, such as high-throughput synthesis, catalytic research, drug screening, etc. By performing multiple reactions simultaneously, the experimental efficiency can be greatly improved, and the study of multiple reaction conditions can be made more convenient and efficient. This equipment has a wide range of applications in organic synthesis, drug development, materials science and other fields.

[0003] In the prior art, the design of parallel reactors usually integrates and fixes the cooling device directly with the instrument body. Although this integrated design simplifies the steps during installation, it also brings certain limitations. Since the cooling device cannot be disassembled or moved independently, users often face the trouble of inconvenient operation when they need to use the cooling device on other instruments of the same type. This non-detachable design not only limits the flexibility of the cooling device, but also makes it impossible for users to share the same cooling device between multiple devices, thereby reducing the efficiency of equipment use. In addition, since the cooling device cannot be easily disassembled and assembled, it becomes relatively difficult to replace or maintain these devices, which further affects the overall use effect and convenience of the instrument. Therefore, a twelve-station parallel reactor is proposed to solve the above problems. Utility Model Content

[0004] In order to make up for the above shortcomings, the utility model provides a twelve-station parallel reactor, aiming to improve the parallel reactors in the prior art that the cooling device is directly fixed on the instrument and cannot be disassembled, resulting in the inability to disassemble and fix the cooling device to other identical instruments for use.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a twelve-station parallel reactor, comprising a lower cooling plate, an upper cooling plate attached to the upper surface of the lower cooling plate, a plurality of single air extraction holes fixedly connected to the upper surface of the upper cooling plate, a plurality of single air extraction holes fixedly connected to the inner sides of the single air extraction holes are fixedly connected to a centralized air supply hole, a placement groove is provided through the lower cooling plate and the upper cooling plate, a left-right symmetrical gripping handle is fixedly connected to one side of the outer wall of the lower cooling plate, a liquid inlet pipe is fixedly connected to one side of the outer wall of the lower cooling plate, and the liquid inlet pipe is mutually connected. A liquid outlet pipe is fixedly connected to the adjacent side, a positioning groove is opened inside the lower cooling plate, a fixed plate is slidably connected to the lower surface of the lower cooling plate, a triangular positioning block is fixedly connected to the upper surface of the fixed plate, the triangular positioning block is slidably connected to the inner wall of the positioning groove, the lower cooling plate and the upper cooling plate are connected by bolts, a polyfluoro protective column is fitted on the lower surface of the fixed plate, a twelve-station pallet is fitted on the lower surface of the polyfluoro protective column, and sensor holes are penetrated inside the lower cooling plate, the upper cooling plate, the fixed plate and the twelve-station pallet.

[0006] Furthermore, an ice water channel is provided inside the lower cooling plate, and the ice water channel is arranged on a side adjacent to the placement groove.

[0007] Furthermore, a circular groove is arranged inside the lower cooling plate, and the circular groove is arranged at the middle side inside the lower cooling plate.

[0008] Furthermore, a gasket groove is provided inside the lower cooling plate, a placement groove is provided inside the lower cooling plate, and a through hole is provided through one side of the placement groove.

[0009] Furthermore, a mounting bolt 1 is provided through the interior of the fixing plate, and the mounting bolt 1 is threadedly connected to the interior of the polytetrafluoroethylene protective column.

[0010] Furthermore, a second mounting bolt is provided through the interior of the twelve-station support plate, and the second mounting bolt is threadedly connected to the interior of the polytetrafluoroethylene protective column.

[0011] Furthermore, placement grooves are provided inside the twelve-station support plate, the number of the placement grooves corresponds to the number of the placement slots, and the single air extraction holes and the centralized air supply holes are both arranged in a pagoda-shaped structure.

[0012] Furthermore, a second liquid inlet pipe is provided on one side of the twelve-station support plate, and a second liquid outlet pipe is fixedly connected to an adjacent side of the second liquid inlet pipe.

[0013] The utility model has the following beneficial effects:

[0014] 1. In the utility model, the positioning groove inside the lower cooling plate is engaged with the triangular positioning block by holding the grip handle, thereby achieving the effect of quick placement and installation. At the same time, through the cooperation of the set mounting bolts 1 and 2, the effect of easy disassembly and placement is achieved, thereby improving the practicality of the instrument.

[0015] 2. In the utility model, by cooperating with the first liquid inlet pipe and the first liquid outlet pipe, the injection of coolant is facilitated to be efficiently transmitted, thereby achieving the effect of circulating cooling. At the same time, by cooperating with the second liquid inlet pipe and the second liquid outlet pipe, the effect of further circulating cooling is achieved, thereby improving the practicality of the instrument. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a three-dimensional structural schematic diagram of a twelve-station parallel reactor proposed by the utility model;

[0017] Figure 2 This is a schematic diagram of a twelve-station parallel reactor proposed by the utility model;

[0018] Figure 3 This is a schematic diagram of the structure of a tetrafluoro protective column of a twelve-station parallel reactor proposed by the utility model;

[0019] Figure 4 This is a schematic diagram of the structure of the lower cooling plate of a twelve-station parallel reactor proposed by the utility model;

[0020] Figure 5 This is a schematic diagram of the structure of the gasket groove of a twelve-station parallel reactor proposed by the utility model;

[0021] Figure 6 The utility model provides a schematic diagram of the circular groove structure of a twelve-station parallel reactor.

[0022] Legend:

[0023] 1. Lower cooling plate; 2. Upper cooling plate; 3. Single exhaust hole; 4. Centralized air supply hole; 5. Placement groove; 6. Holding handle; 7. Liquid inlet pipe one; 8. Liquid outlet pipe one; 9. Gasket groove; 10. Through hole; 11. Sensor hole; 12. Ice water channel; 13. Circular groove; 14. Positioning groove; 15. Fixed plate; 16. Triangular positioning block; 17. PTFE protective column; 18. Twelve-station pallet; 19. Placement groove; 20. Liquid inlet pipe two; 21. Liquid outlet pipe two; 22. Mounting bolt one; 23. Mounting bolt two. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] Reference Figure 1 - Figure 6 The utility model provides an embodiment: a twelve-station parallel reactor, comprising a lower cooling plate 1, an upper cooling plate 2 is attached to the upper surface of the lower cooling plate 1, a plurality of single air extraction holes 3 are fixedly connected to the upper surface of the upper cooling plate 2, a plurality of single air extraction holes 3 are fixedly connected to the inner sides of the multiple single air extraction holes 3, a placement groove 5 is opened through the lower cooling plate 1 and the upper cooling plate 2, a left-right symmetrical holding handle 6 is fixedly connected to one side of the outer wall of the lower cooling plate 1, a liquid inlet pipe 7 is fixedly connected to one side of the outer wall of the lower cooling plate 1, and a liquid outlet pipe 7 is fixedly connected to the adjacent side of the liquid inlet pipe 7 8. A positioning groove 14 is provided inside the lower cooling plate 1. A fixed plate 15 is slidably connected to the lower surface of the lower cooling plate 1. A triangular positioning block 16 is fixedly connected to the upper surface of the fixed plate 15. The triangular positioning block 16 is slidably connected to the inner wall of the positioning groove 14. The lower cooling plate 1 and the upper cooling plate 2 are connected by bolts. A polyfluoro protective column 17 is attached to the lower surface of the fixed plate 15. A twelve-station support plate 18 is attached to the lower surface of the polyfluoro protective column 17. The lower cooling plate 1, the upper cooling plate 2, the fixed plate 15 and the twelve-station support plate 18 are all provided with sensor holes 11.

[0026] Specifically, the lower cooling plate 1 and the upper cooling plate 2 are firmly connected by means of the placement groove 5 penetrating inside and the bolt fixing method, ensuring the close fit of each part; the holding handle 6 on the lower cooling plate 1 is symmetrically arranged on the left and right, so that the operator can obtain a good grip during disassembly and assembly, thereby improving the stability of the equipment and the safety of operation; the ice water channel 12 and the circular groove 13 design inside the lower cooling plate 1 provide an optimized fluid path for the cooling system, ensuring the uniformity and efficiency of the cooling effect; through the liquid inlet pipe 7 and the liquid outlet pipe 8, the liquid can smoothly enter and exit the equipment; the combined design of the fixed plate 15 and the triangular positioning block 16 makes the installation of the equipment more precise, and through the cooperation of the positioning groove 14 and the polytetrafluoroethylene protective column 17, the connection between the components is realized, which not only simplifies the assembly process, but also ensures the integrity of each component during disassembly and assembly; the mounting bolts 23 on the twelve-station pallet 18 cooperate with the mounting bolts 22 on the fixed plate 15 to further ensure the stability of the entire reactor.

[0027] Reference Figure 1 - Figure 6, an ice water channel 12 is provided inside the lower cooling plate 1, and the ice water channel 12 is arranged on the side adjacent to the placement groove 5; a circular groove 13 is provided inside the lower cooling plate 1, and the circular groove 13 is arranged on the middle side inside the lower cooling plate 1; a gasket groove 9 is provided inside the lower cooling plate 1, and a placement groove 5 is provided inside the lower cooling plate 1, and a through hole 10 is provided through one side of the placement groove 5; a mounting bolt 23 is provided through the inside of the twelve-station support plate 18, and the mounting bolt 23 is threadedly connected to the inside of the polyfluoro protective column 17; a placement groove 19 is provided inside the twelve-station support plate 18, and the number of the placement grooves 19 corresponds to the number of the placement grooves 5, and the single exhaust hole 3 and the centralized air supply hole 4 are both arranged in a pagoda-shaped structure; a liquid inlet pipe 20 is provided on one side of the twelve-station support plate 18, and a liquid outlet pipe 21 is fixedly connected to the adjacent side of the liquid inlet pipe 20;

[0028] Specifically, an ice water channel 12 is provided inside the lower cooling plate 1, and the ice water channel 12 is located on the adjacent side of the placement groove 5. By optimizing the fluid path, the cooling medium can be evenly distributed around the reaction tube, thereby effectively controlling the temperature of each station; at the same time, a circular groove 13 is also provided inside the lower cooling plate 1, which is located on the middle side of the cooling plate 1, and is used to accommodate the airway structure between the upper and lower sealing surfaces of the cooling plate, which not only enhances the sealing effect, but also provides a reliable channel for gas circulation; a sealing gasket can be installed through the provided gasket groove 9, and the surrounding of the placement groove 5 is close to the ice water channel 12, which ensures the effective circulation of the cooling medium during the reaction process; a through hole 10 is also provided on one side of the placement groove 5, which helps to observe the reaction situation in the reaction tube and avoid the influence of water accumulation on the operation of the equipment; a mounting bolt 22 provided through the fixed plate 15 is threadedly connected to the polyfluoro protective column 17 to ensure the firm connection of the fixed plate with other structures, thereby enhancing the overall stability and sealing performance; the twelve-station support plate 18 is an important component of the reactor, and multiple functional structures are also provided inside it, including Mounting bolt 23 and placement groove 19; the threaded connection between the mounting bolt 23 and the polytetrafluoroethylene protective column 17 ensures the stable positioning of the support plate 18, and the placement groove 19 corresponds to the placement groove 5 one by one, providing a reliable reaction tube placement position; in addition, the liquid inlet 20 and the liquid outlet pipe 21 arranged on the twelve-station support plate 18 are both pagoda-shaped structures, which further optimizes the supply and extraction effect of the liquid, and the twelve-station support plate 18 passes cooling liquid when performing low-temperature reactions; the twelve-station support plate 18 can also be a solid structure to provide a heating function to ensure that the liquid environment of each reaction station is consistent; in order to improve the convenience of operation of the equipment, a liquid inlet pipe 7 is also arranged on one side of the lower cooling plate 1, and a liquid outlet pipe 8 is fixedly connected to the adjacent side of the liquid inlet pipe 7. This design makes the entry and exit of the cooling medium more convenient, and the user can adjust the flow rate and flow rate of the cooling fluid according to actual needs to ensure the cooling efficiency of each reaction tube; in addition, these designs all adopt Teflon spraying technology, which not only improves the corrosion resistance of the equipment, but also reduces friction and wear during operation, and extends the service life of the equipment.

[0029] Working principle: When in use, the twelve-station parallel reactor consists of an upper cooling plate 2 and a lower cooling plate 1. The upper cooling plate 2 is provided with a centralized air supply hole 4 in the center, and twelve air extraction holes 3 are evenly arranged around it. These holes are connected by bolts to form a sealing structure, so that the gas can be centrally supplied and extracted from each reaction position, entering the airway chamber 13 on the sealing surface of the cooling plate to form a stable airflow. The ice water channel 12 formed by the sealing surface of the cooling plate around the reaction tube studio controls the cooling effect through the liquid inlet pipe 7 and the liquid outlet pipe 8. The holding device 6 is located on both sides of the cooling plate 1 for easy operation. The alignment assembly device ensures the precise alignment of the upper and lower cooling plates, the fixed plate 15, and the twelve-station support plate 18 through the isosceles triangle groove 14 and the matching triangular positioning block. Each component is provided with a through sensor hole 11 to monitor the temperature in real time, and the design of the placement groove 5, the ice water channel 12, and the circular groove 13 ensures the uniform cooling and stability of each reaction tube.

[0030] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A twelve-station parallel reactor, comprising a lower cooling plate (1), characterized in that: The upper surface of the lower cooling plate (1) is fitted with an upper cooling plate (2), and a plurality of single air extraction holes (3) are fixedly connected to the upper surface of the upper cooling plate (2), and a centralized air supply hole (4) is fixedly connected to the inner side of the plurality of single air extraction holes (3). A placement groove (5) is provided inside the lower cooling plate (1) and the upper cooling plate (2), and a left-right symmetrical holding handle (6) is fixedly connected to one side of the outer wall of the lower cooling plate (1). A liquid inlet pipe (7) is fixedly connected to one side of the outer wall of the lower cooling plate (1), and a liquid outlet pipe (8) is fixedly connected to the adjacent side of the liquid inlet pipe (7). A positioning groove (14) is provided inside the lower cooling plate (1). ), the lower surface of the lower cooling plate (1) is slidably connected to a fixed plate (15), the upper surface of the fixed plate (15) is fixedly connected to a triangular positioning block (16), the triangular positioning block (16) is slidably connected to the inner wall of the positioning groove (14), the lower cooling plate (1) and the upper cooling plate (2) are internally connected by bolts, the lower surface of the fixed plate (15) is fitted with a polyfluoro protective column (17), the lower surface of the polyfluoro protective column (17) is fitted with a twelve-station support plate (18), and the lower cooling plate (1), the upper cooling plate (2), the fixed plate (15) and the twelve-station support plate (18) are all penetrated by sensor holes (11).

2. A twelve-station parallel reactor according to claim 1, characterized in that: An ice water channel (12) is provided inside the lower cooling plate (1), and the ice water channel (12) is arranged on a side adjacent to the placement groove (5).

3. A twelve-station parallel reactor according to claim 2, characterized in that: A circular groove (13) is arranged inside the lower cooling plate (1), and the circular groove (13) is arranged at the middle side inside the lower cooling plate (1).

4. A twelve-station parallel reactor according to claim 3, characterized in that: A gasket groove (9) is provided inside the lower cooling plate (1), a placement groove (5) is provided inside the lower cooling plate (1), and a through hole (10) is provided through one side of the placement groove (5).

5. A twelve-station parallel reactor according to claim 4, characterized in that: A mounting bolt (22) is provided through the interior of the fixing plate (15), and the mounting bolt (22) is threadedly connected to the interior of the polytetrafluoroethylene protective column (17).

6. A twelve-station parallel reactor according to claim 1, characterized in that: A second mounting bolt (23) is provided through the interior of the twelve-station support plate (18), and the second mounting bolt (23) is threadedly connected to the interior of the polytetrafluoroethylene protective column (17).

7. A twelve-station parallel reactor according to claim 6, characterized in that: The twelve-station support plate (18) is provided with placement grooves (19) therein, the number of the placement grooves (19) corresponds to the number of the placement slots (5), and the single air extraction holes (3) and the centralized air supply holes (4) are both arranged in a pagoda-shaped structure.

8. A twelve-station parallel reactor according to claim 7, characterized in that: A second liquid inlet pipe (20) is provided on one side of the twelve-station support plate (18), and a second liquid outlet pipe (21) is fixedly connected to an adjacent side of the second liquid inlet pipe (20).

Images