Immune isolation device

Abstract

The utility model discloses an immune isolation device which comprises an upper sleeve body, a lower sleeve body is arranged at the bottom of the upper sleeve body, an isolation piece is arranged between the upper sleeve body and the lower sleeve body, the isolation piece is provided with an end, a protection mechanism used for enabling the outer portion of the end to form a fence is arranged on the side portion of the upper sleeve body, and the protection mechanism comprises a connecting cylinder and a connecting ring. The connecting cylinder is connected between the upper sleeve body and the lower sleeve body in a sliding and penetrating mode, the connecting ring is located outside the end head, the connecting cylinder and the connecting ring are used for limiting the position of the end head, the fixing cylinder is located on the side portion of the connecting ring, and the side portion of the end head is located in the protective cylinder. The connecting cylinder, the connecting ring, the fixing cylinder, the protective cylinder and the fixing plate are matched with one another, the end head is inserted into the inner cavities of the connecting cylinder and the connecting ring, and the protective cylinder and the fixing cylinder shield the end head, so that the exposed position of the end head can be sealed and shielded, and the end head can be prevented from being polluted or damaged by the outside.

Description

Technical Field

[0001] The utility model relates to the field of immune isolation devices, in particular to an immune isolation device. Background Art

[0002] As we all know, diabetic patients need treatment. When treating diabetes, IPS-derived cell therapy will be used, and then an immunoisolation device will be used. The immunoisolation device is made of a biocompatible capsule, which can protect allogeneic cells from receptor rejection. When used for minimally invasive implantation under the abdomen, it can induce the growth of capillaries close to the capsule. This vascularization function can provide a rich blood supply to nourish the capsule tissue within the cell, help the implanted cells communicate with the host, and ensure the rapid delivery of therapeutic molecules.

[0003] The immunoisolation device of the prior art usually includes a sterile treatment cover and an isolation member, wherein the isolation member is located inside the sterile treatment cover and the sterile treatment cover can protect the isolation member. The isolation member usually includes an outer membrane, an inner membrane, a non-woven polyester mesh and an end cap, wherein the non-woven polyester mesh backing is attached to the outside of the outer membrane, the inner membrane is located inside the outer membrane, and the end cap is located on the side of the outer membrane.

[0004] The end cap is usually inserted into the side of the sterile treatment cover and is arranged to penetrate the end cap. Part of the end cap is located outside the sterile treatment cover. However, this method may cause improper handling when the immunoisolation device is taken out of the storage box and carried, resulting in accidental contact of the end cap, affecting the stability of the end cap or causing contamination. The immunoisolation device is not convenient for shielding and protecting the end cap, and has certain limitations. Utility Model Content

[0005] The purpose of the utility model is to provide an immune isolation device to solve the problems raised in the above background technology.

[0006] To achieve the above purpose, the utility model provides the following technical solution: an immune isolation device, comprising:

[0007] An upper sleeve body, wherein a lower sleeve body is disposed at the bottom of the upper sleeve body, an isolating piece is disposed between the upper sleeve body and the lower sleeve body, and a terminal is disposed at a side of the isolating piece;

[0008] The side of the upper sleeve body is provided with a protection mechanism for forming a fence around the outside of the end head, and the protection mechanism includes:

[0009] A connecting tube and a connecting ring, wherein the connecting tube is slidably inserted and connected between the upper sleeve body and the lower sleeve body, and the connecting ring is located outside the end head, and the connecting tube and the connecting ring are used to limit the position of the end head;

[0010] A fixing tube and a protective tube, wherein the fixing tube is located at the side of the connecting ring, the side of the end head is located inside the protective tube, and the protective tube is used to shield and protect the end head.

[0011] Preferably, the connecting ring is fixedly connected to the side of the connecting tube, the end head is slidably and interlacedly connected to the inner cavities of the connecting tube and the connecting ring, and the fixing tube is fixedly connected to the side of the connecting ring.

[0012] Preferably, the outer wall of the protection tube is threadably connected to the inner cavity of the fixing tube, and the outer wall of the protection tube is fixedly connected to a fixing plate.

[0013] Preferably, a sealing assembly is provided on the other side of the upper sleeve, and the sealing assembly includes a connecting frame, an inner wall of the connecting frame is fixedly connected with a sealing plug, and the sealing plug is slidably inserted and connected between the upper sleeve and the lower sleeve.

[0014] Preferably, a support plate is fixedly connected to a side of the sealing plug, and a blocking piece is fixedly connected to a side of the support plate.

[0015] Preferably, the isolation element comprises an outer membrane and an inner membrane, and the inner membrane is located inside the outer membrane.

[0016] Preferably, the outer part of the upper sleeve is fixedly connected with an upper side part, the outer part of the lower sleeve is fixedly connected with a lower side part, and the bottom end of the upper side part is fixedly connected with the top end of the lower side part.

[0017] Technical effects and advantages of the utility model:

[0018] The utility model utilizes the mutual cooperation of the connecting tube, the connecting ring, the fixing tube, the protective tube and the fixing plate, the end head is interlaced with the inner cavity of the connecting tube and the connecting ring, and the end head and the inner wall of the connecting tube have a certain extrusion force, the protective tube and the fixing tube shield the end head, which is beneficial to seal and shield the exposed position of the end head, and prevent the end head from being polluted or damaged by the outside. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the front structure of the utility model.

[0020] Figure 2 It is a schematic diagram of the cross-sectional structure of the utility model in top view.

[0021] Figure 3 It is a schematic diagram of the top cross-sectional structure of the isolation member of the utility model.

[0022] Figure 4 For this utility model Figure 2 Enlarged structural diagram at A in the middle.

[0023] Figure 5It is a schematic diagram of the structure of the protective tube of the utility model.

[0024] In the figure: 1. upper casing; 2. lower casing; 3. upper edge; 4. lower edge; 5. spacer; 51. outer membrane; 52. inner membrane; 6. protection mechanism; 61. connecting tube; 62. connecting ring; 63. fixing tube; 64. protection tube; 65. fixing plate; 7. sealing assembly; 71. connecting frame; 72. sealing plug; 73. support plate; 74. baffle; 8. end. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] The utility model provides Figure 1-5The immunoisolation device shown in the figure comprises an upper casing 1, a lower casing 2 is arranged at the bottom of the upper casing 1, a cavity is formed between the upper casing 1 and the lower casing 2, so that the isolating element is inserted into the interior of the cavity to isolate and protect the isolating element 5, the upper casing 1 is fixedly connected to the outside with an upper edge 3, the connection between the upper edge 3 and the lower edge 4 forms a tight connection between the upper casing 1 and the lower casing 2, the lower casing 2 is fixedly connected to the outside with a lower edge 4, the bottom end of the upper edge 3 is fixedly connected to the top end of the lower edge 4, an isolating element 5 is arranged between the upper casing 1 and the lower casing 2, the isolating element 5 comprises an outer membrane 51 and an inner membrane 52, the outer membrane 51 is composed of a 5-micron polytetrafluoroethylene membrane, laminated on an inner 0.45-micron PTFE layer and is hydrophilic, the outer membrane 51 is a vascularized membrane, which has the ability to induce the formation of new blood vessels, a non-woven polyester mesh backing is attached to the outside of the vascularized membrane, two membrane plates are then covered with a woven polyester mesh and finally ultrasonically welded to form a rectangular device with a volume of 40 ul, the inner membrane 52 is located inside the outer membrane 51, and the side of the isolation member 5 is provided with an end 8, which is made of polyethylene. The polyethylene end 8 allows entry into the inner cavity of the device for loading. The end 8 is used to introduce the device of the microdialysis probe. During implantation, glue is used, which is silicone rubber medical adhesive silicone resin type A to seal the port to prevent tissue from growing into the device. Before implantation, the immunoisolation device is immersed in 95% alcohol for 1-2 minutes, and then thoroughly rinsed in saline. The outer polyester mesh supports the film, and the isolation member 5 is removed from the interior of the upper sleeve 1 and the lower sleeve 2. The TheraCell capsule is disinfected with 100% and 70% ethanol washes before washing three times with sterile saline for 20 minutes. A suitable cell suspension is placed in a Hamilton syringe with a 26-gauge blunt needle, and the needle is inserted into the device end 8 guided to the capsule, and then the silicone adhesive is injected to seal the device end 8 for sealing.

[0027] Furthermore, a protective mechanism 6 for forming a barrier on the outside of the end head 8 is provided on the side of the upper sleeve 1. The protective mechanism 6 includes a connecting tube 61 and a connecting ring 62. The connecting tube 61 is made of sterile rubber material. The inner wall of the connecting tube 61 has a certain extrusion force with the end head 8, which is conducive to limiting the protection of the end head 8, facilitating the restraint of the end head 8 and preventing the end head 8 from sliding randomly. The connecting ring 62 is conducive to supporting the connecting tube 61. The connecting tube 61 is slidably inserted and connected between the upper sleeve 1 and the lower sleeve 2. The connecting ring 62 is located on the outside of the end head 8. The connecting tube 61 and the connecting ring 62 are used to limit the position of the end head 8, the fixing tube 63 and the protective tube 64. The fixing tube 63 is conducive to the protection tube 6 4 are connected to each other, which is convenient for supporting and installing the protection tube 64. The protection tube 64 is beneficial for shielding and protecting the exposed part of the end head 8 to prevent the end head 8 from being damaged. The fixing tube 63 is located on the side of the connecting ring 62, and the side of the end head 8 is located inside the protection tube 64. The protection tube 64 is used to shield and protect the end head 8. The connecting ring 62 is fixedly connected to the side of the connecting tube 61, and the end head 8 and the inner cavities of the connecting tube 61 and the connecting ring 62 are all slidably inserted and connected. The fixing tube 63 is fixedly connected to the side of the connecting ring 62, and the outer wall of the protection tube 64 is threadedly inserted and connected with the inner cavity of the fixing tube 63. The outer wall of the protection tube 64 is fixedly connected with a fixing plate 65, which is beneficial for rotating the protection tube 64 and convenient operation.

[0028] Furthermore, a sealing assembly 7 is provided on the other side of the upper sleeve 1, and the sealing assembly 7 includes a connecting frame 71. The connecting frame 71 is conducive to supporting the sealing plug 72 and facilitating the installation of the sealing plug 72. The inner wall of the connecting frame 71 is fixedly connected with the sealing plug 72. The sealing plug 72, the support plate 73 and the baffle 74 are all made of sterile rubber material, which is conducive to sealing the cavity and limiting the isolation member 5. The sealing plug 72 is slidably inserted and connected between the upper sleeve 1 and the lower sleeve 2. The side of the sealing plug 72 is fixedly connected with the support plate 73, and the side of the support plate 73 is fixedly connected with the baffle 74.

[0029] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An immunoisolation device, comprising: An upper casing (1), wherein a lower casing (2) is arranged at the bottom of the upper casing (1), an isolating member (5) is arranged between the upper casing (1) and the lower casing (2), and a terminal (8) is arranged at the side of the isolating member (5); The invention is characterized in that a protective mechanism (6) for forming a fence around the outside of the end head (8) is provided on the side of the upper sleeve (1), and the protective mechanism (6) comprises: a connecting tube (61) and a connecting ring (62), wherein the connecting tube (61) is slidably inserted and connected between the upper sleeve (1) and the lower sleeve (2), and the connecting ring (62) is located outside the end head (8), and the connecting tube (61) and the connecting ring (62) are used to limit the position of the end head (8); A fixing tube (63) and a protective tube (64), wherein the fixing tube (63) is located on the side of the connecting ring (62), the side of the end head (8) is located inside the protective tube (64), and the protective tube (64) is used to shield and protect the end head (8).

2. An immunoisolation device according to claim 1, characterized in that: The connecting ring (62) is fixedly connected to the side of the connecting tube (61), the end head (8) is slidably connected to the inner cavities of the connecting tube (61) and the connecting ring (62), and the fixing tube (63) is fixedly connected to the side of the connecting ring (62).

3. An immunoisolation device according to claim 1, characterized in that: The outer wall of the protection tube (64) is threadably connected to the inner cavity of the fixing tube (63), and the outer wall of the protection tube (64) is fixedly connected to a fixing plate (65).

4. An immunoisolation device according to claim 1, characterized in that: A sealing assembly (7) is provided on the other side of the upper casing (1), the sealing assembly (7) comprising a connecting frame (71), the inner wall of the connecting frame (71) being fixedly connected with a sealing plug (72), the sealing plug (72) being slidably inserted and connected between the upper casing (1) and the lower casing (2).

5. An immunoisolation device according to claim 4, characterized in that: A support plate (73) is fixedly connected to the side of the sealing plug (72), and a blocking sheet (74) is fixedly connected to the side of the support plate (73).

6. An immunoisolation device according to claim 1, characterized in that: The isolation element (5) comprises an outer film (51) and an inner film (52), wherein the inner film (52) is located inside the outer film (51).

7. An immunoisolation device according to claim 1, characterized in that: The outer portion of the upper casing (1) is fixedly connected to an upper side portion (3), the outer portion of the lower casing (2) is fixedly connected to a lower side portion (4), and the bottom end of the upper side portion (3) is fixedly connected to the top end of the lower side portion (4).

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