Nitrogen-protected reaction kettle

Abstract

The utility model belongs to the technical field of reaction kettle equipment, and particularly relates to a nitrogen-protected reaction kettle, which comprises a reaction kettle body, a nitrogen replacement device communicated with the bottom of the reaction kettle body and used for providing nitrogen into the reaction kettle body, and an air extractor communicated with the top of the reaction kettle body and used for discharging the nitrogen from the reaction kettle body, the vacuum meter is arranged on the reaction kettle body and is used for detecting the vacuum degree in the reaction kettle body. In the reaction kettle, the nitrogen replacement device is located at the bottom of the reaction kettle body, the gas extractor is located at the top of the reaction kettle body, gas floats upwards to ensure that nitrogen and a solution in the reaction kettle are fully mixed, so that the replacement efficiency of oxygen is improved, and the contact area and the contact time of the nitrogen and liquid are remarkably improved; by arranging the vacuum meter, the vacuum degree in the kettle can be monitored and displayed in real time, visual data support is provided for operators, and the replacement efficiency can be further improved under the condition that the interior of the reaction kettle body is kept at a certain vacuum degree.

Description

[Technical field]

[0001] The present application belongs to the technical field of reactor equipment, and in particular relates to a nitrogen-protected reactor. [Background technology]

[0002] As people's living standards improve, the quality requirements for medicines are getting higher and higher, that is, the requirements for medicine production equipment are getting higher and higher. Some products are prone to oxidation during the production process, and nitrogen needs to be used to replace the oxygen in the water. At present, almost all of them use nitrogen filling on the reactor for deoxygenation, and there is no height difference between the air inlet and the air outlet, so that the contact between nitrogen and liquid is not sufficient, resulting in incomplete oxygen replacement, and the dissolved oxygen in the water cannot be controlled at a low level, which ultimately leads to varying degrees of oxidation of the medicine. [Utility Model Content]

[0003] In order to solve the problem in the prior art that the contact between nitrogen and liquid is not sufficient, resulting in incomplete oxygen replacement, the present application provides a nitrogen-protected reactor that can control the dissolved oxygen in water at a lower level.

[0004] This application is implemented through the following technical solutions:

[0005] A nitrogen-protected reactor comprises a reactor body, a nitrogen replacement device connected to the bottom of the reactor body and providing nitrogen to the inside of the reactor body, an exhaust device connected to the top of the reactor body and used for exhausting nitrogen from the reactor body, and a vacuum gauge arranged on the reactor body and used for detecting the vacuum degree in the reactor body.

[0006] In the nitrogen-protected reactor as described above, the exhaust device includes an exhaust pipe, an exhaust pump disposed on the exhaust pipe, and a first one-way valve disposed on the exhaust pipe and located between the exhaust pump and the reactor body.

[0007] In the nitrogen-protected reactor as described above, the nitrogen replacement device includes an air inlet pipe, and the air inlet pipe includes a guide section located outside the reactor body and a diversion section located inside the reactor body, and a flow meter is provided on the guide section.

[0008] In the nitrogen-protected reactor as described above, the diversion section is arranged around the bottom edge of the reactor body, and a plurality of openings are provided on the diversion section.

[0009] In the nitrogen-protected reactor as described above, the guide section is provided with a first valve and a second valve respectively located on both sides of the flow meter in sequence along the air inlet direction.

[0010] The nitrogen-protected reactor as described above further includes a pressure sensor disposed on the reactor body and used to detect the internal pressure of the reactor body.

[0011] The nitrogen-protected reactor as described above further includes a water inlet pipe for supplying liquid into the interior of the reactor body.

[0012] In the nitrogen-protected reactor as described above, the water inlet pipe is connected to the air inlet pipe, and the connection node is located behind the second valve.

[0013] The nitrogen-protected reactor as described above further includes a third valve arranged on the water inlet pipe, wherein the third valve is located in front of a conducting node between the water inlet pipe and the air inlet pipe.

[0014] In the nitrogen-protected reactor as described above, the aperture of the opening is less than 3 mm.

[0015] Compared with the prior art, this application has the following advantages:

[0016] The present application discloses a nitrogen-protected reactor, in which a nitrogen replacement device is located at the bottom of the reactor body, and a vacuum device is located at the top of the reactor body. The gas floats upward to ensure that the nitrogen is fully mixed with the solution in the reactor, thereby improving the replacement efficiency of oxygen, significantly improving the contact area and contact time between nitrogen and liquid, so that oxygen can be better replaced by nitrogen. By setting a vacuum gauge, the vacuum degree in the reactor can be monitored and displayed in real time, providing intuitive data support for operators, making the production process more controllable and accurate, and maintaining the interior of the reactor body at a certain vacuum degree to further improve the replacement efficiency.

Brief Description of the Drawings

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 It is a three-dimensional stereogram in the embodiment of the present application;

[0019] Figure 2 yes Figure 1 A top view of the reactor body;

[0020] Figure 3 yes Figure 2 Cross-sectional view at AA in the middle. [Specific implementation method]

[0021] In order to make the technical problems, technical solutions and beneficial effects solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0022] See also Figures 1 to 3 A nitrogen-protected reactor comprises a reactor body 1, a nitrogen replacement device 2 connected to the bottom of the reactor body 1 and providing nitrogen to the inside of the reactor body 1, an exhaust device 3 connected to the top of the reactor body 1 and used for exhausting the inside of the reactor body 1, and a vacuum gauge 4 provided on the reactor body 1 and used for detecting the vacuum degree inside the reactor body 1.

[0023] The present application discloses a nitrogen-protected reactor, in which a nitrogen replacement device is located at the bottom of the reactor body, and a vacuum device is located at the top of the reactor body. The gas floats upward to ensure that the nitrogen is fully mixed with the solution in the reactor, thereby improving the replacement efficiency of oxygen, significantly improving the contact area and contact time between nitrogen and liquid, so that oxygen can be better replaced by nitrogen. By setting a vacuum gauge, the vacuum degree in the reactor can be monitored and displayed in real time, providing intuitive data support for operators, making the production process more controllable and accurate, and maintaining the interior of the reactor body at a certain vacuum degree to further improve the replacement efficiency.

[0024] Furthermore, as a preferred embodiment of the present invention but not a limitation, the exhaust device 3 includes an exhaust pipe 31, an exhaust pump 32 provided on the exhaust pipe 31, and a first one-way valve 33 provided on the exhaust pipe 31 and located between the exhaust pump 32 and the reactor body 1.

[0025] In this embodiment, by equipping the vacuum pump, the air in the reactor body can be actively extracted, effectively reducing the air pressure inside the reactor, thereby accelerating the nitrogen replacement process and improving the deoxygenation efficiency. At the same time, the first one-way valve arranged on the exhaust pipe ensures that during the vacuum process, the outside air will not flow back into the reactor, thereby ensuring the purity of the gas environment inside the reactor. In addition, after reaching the required vacuum degree of -0.05 to -0.02MPa, the vacuum pump stops working, and the first one-way valve will automatically close to prevent the outside air from entering the reactor through the exhaust pipe, thereby ensuring the strict requirements for oxygen control in the drug production process, effectively avoiding the occurrence of oxidation reactions, and ensuring the quality of drugs. This design not only improves production efficiency, but also ensures the safety and stability of drugs.

[0026] Furthermore, as a preferred embodiment of the present invention but not a limitation, the nitrogen replacement device 2 includes an air inlet pipe 21, the air inlet pipe 21 includes a guide section 211 located on the outside of the reactor body 1 and a diversion section 212 located on the inside of the reactor body 1, and a flow meter 22 is provided on the guide section 211.

[0027] In this embodiment, by arranging a flow meter on the guide section of the air inlet pipe, the flow rate of nitrogen can be monitored in real time, and the flow rate of nitrogen can be adjusted as needed to ensure that the rate of nitrogen input into the reactor body is accurately controllable. When the reactor body slowly returns to positive pressure during the process of filling with nitrogen, the first one-way valve automatically opens to unload the pressure in the reactor body and automatically discharge excess gas. The diversion section is responsible for evenly distributing the nitrogen to the inside of the reactor, thereby improving the contact efficiency between nitrogen and the internal air and speeding up the replacement process. This configuration not only improves the efficiency and effect of nitrogen replacement, but also helps to accurately control the supply of nitrogen, avoid waste, and ensure that the strict requirements for the gas environment in the drug production process are met, thereby ensuring the quality and safety of the drug.

[0028] Furthermore, as a preferred implementation of the present solution but not a limitation, the diversion section 212 is arranged around the bottom edge of the reactor body 1 , and a plurality of openings are provided on the diversion section 212 .

[0029] In this embodiment, the uniform distribution and full mixing of nitrogen inside the reactor can be effectively promoted. This layout enables nitrogen to form a uniform gas layer at the bottom of the reactor, and gradually release it into the working area of ​​the reactor through the openings, thereby improving the efficiency of nitrogen replacing air, ensuring a uniform gas environment throughout the reactor, and avoiding oxidation problems caused by excessive local oxygen concentration. In addition, the surrounding diversion section can also reduce the dead corners and retention areas of nitrogen, further improving the thoroughness of nitrogen replacement, and playing a key role in improving the quality and safety of drug production.

[0030] Furthermore, as a preferred implementation of the present solution but not a limitation, the guide section 211 is provided with a first valve 7 and a second valve 8 respectively located on both sides of the flow meter 22 in sequence along the air intake direction.

[0031] Furthermore, as a preferred implementation manner of the present solution but not limiting, it further includes an air pressure sensor 9 which is arranged on the reactor body 1 and is used to detect the air pressure inside the reactor body 1 .

[0032] In this embodiment, the air pressure conditions inside the reactor can be monitored in real time to ensure the accuracy and efficiency of the nitrogen replacement process. By providing continuous air pressure data, the operator can adjust the nitrogen input and emission rate in time to maintain an ideal air pressure environment and avoid oxidation or other adverse reactions caused by improper air pressure. It also helps to save energy and reduce emissions and optimize production costs.

[0033] Furthermore, as a preferred implementation manner of the present solution but not limiting, a water inlet pipe 10 for supplying liquid into the interior of the reactor body 1 is also included.

[0034] In this embodiment, the water inlet pipe is positioned so that when the nitrogen replacement device needs to be cleaned, the first valve and the second valve are closed and the third valve is opened to introduce pure water from the water inlet pipe to clean the nitrogen replacement device.

[0035] Furthermore, as a preferred implementation manner of the present solution but not a limitation thereof, the water inlet pipe 10 is connected to the air inlet pipe 21 , and a connection node is located behind the second valve 8 .

[0036] Furthermore, as a preferred implementation manner of the present solution but not a limitation, it also includes a third valve 101 provided on the water inlet pipe 10 , and the third valve 101 is located in front of the conduction node between the water inlet pipe 10 and the air inlet pipe 21 .

[0037] In this embodiment, the positioning arrangement of the third valve allows the liquid inflow to be quickly cut off in an emergency, thereby enhancing the safety and controllability of the system. It also facilitates maintenance or replacement of the valve without affecting the normal use of the intake pipe, thereby improving the operating efficiency and maintenance convenience of the entire system.

[0038] Furthermore, as a preferred implementation manner of the present solution but not a limitation, the aperture of the opening is less than 3 mm.

[0039] In this embodiment, a smaller pore size helps to achieve a finer and more uniform gas distribution, thereby improving the nitrogen replacement efficiency and ensuring the consistency of the gas environment inside the reactor; secondly, such an aperture size can prevent larger particles or impurities from entering the reactor, which helps to maintain the cleanliness inside the reactor and the sanitary standards for drug production; finally, the small pore size can also reduce the turbulence and noise generated by the gas flow rate, reduce energy consumption, and also help protect sensitive equipment or materials inside the reactor from the impact and damage of high-speed airflow, thereby improving the stability and safety of the entire system.

[0040] The working principle of this embodiment is as follows:

[0041] 1. Open the vacuum device on the top of the reactor body to quickly remove the air in the reactor.

[0042] 2. When the vacuum degree in the reactor body reaches about -0.03MPa, stop pumping and the first one-way valve is closed.

[0043] 3. Open the nitrogen replacement device at the bottom, introduce nitrogen, and adjust the nitrogen flow rate as needed. At this time, the vacuum in the reactor body slowly rises. When it rises to positive pressure, the first one-way valve automatically opens to relieve the pressure in the reactor and automatically discharge excess gas.

[0044] 4. Turn off the nitrogen replacement device.

[0045] 5. Repeat steps 2-4 3 times to basically reduce the oxygen content in the solution to a lower level.

[0046] 6. Open the bottom nitrogen replacement device, introduce nitrogen, adjust the valve to a lower flow level, and maintain nitrogen protection throughout the production process.

[0047] The above are implementation methods provided in combination with specific contents, and it is not intended that the specific implementation of this application is limited to these descriptions. Any method structure similar to the present application, or a number of technical deductions or replacements based on the concept of the present application, should be considered as the protection scope of this application.

Claims

1. A nitrogen-protected reactor, characterized in that: It comprises a reactor body (1), a nitrogen replacement device (2) connected to the bottom of the reactor body (1) and supplying nitrogen to the interior of the reactor body (1), an exhaust device (3) connected to the top of the reactor body (1) and used to exhaust the interior of the reactor body (1), and a vacuum gauge (4) provided on the reactor body (1) and used to detect the vacuum degree in the reactor body (1); The nitrogen replacement device (2) comprises an air inlet pipe (21), the air inlet pipe (21) comprising a flow guide section (211) located outside the reactor body (1) and a flow diversion section (212) located inside the reactor body (1), and a flow meter (22) is provided on the flow guide section (211); The flow diversion section (212) is arranged around the bottom edge of the reactor body (1), and a plurality of openings are provided on the flow diversion section (212).

2. A nitrogen-protected reactor according to claim 1, characterized in that: The air extraction device (3) comprises an exhaust pipe (31), an air extraction pump (32) provided on the exhaust pipe (31), and a first one-way valve (33) provided on the exhaust pipe (31) and located between the air extraction pump (32) and the reactor body (1).

3. The nitrogen-protected reactor according to claim 1, characterized in that: The guide section (211) is provided with a first valve (7) and a second valve (8) in sequence along the air intake direction and located respectively on both sides of the flow meter (22).

4. The nitrogen-protected reactor according to claim 1, characterized in that: It also includes an air pressure sensor (9) which is arranged on the reactor body (1) and is used to detect the air pressure inside the reactor body (1).

5. The nitrogen-protected reactor according to claim 3, characterized in that: It also includes a water inlet pipe (10) for supplying liquid into the interior of the reactor body (1).

6. A nitrogen-protected reactor according to claim 5, characterized in that: The water inlet pipe (10) is connected to the air inlet pipe (21), and the connection node is located behind the second valve (8).

7. A nitrogen-protected reactor according to claim 6, characterized in that: It also comprises a third valve (101) arranged on the water inlet pipe (10), wherein the third valve (101) is located in front of a conduction node between the water inlet pipe (10) and the air inlet pipe (21).

8. The nitrogen-protected reactor according to claim 1, characterized in that: The aperture of the opening is less than 0.3 mm.

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