System for preventing volatile solid blockage in synthesis process

By designing a system for preventing volatile solid clogging for the synthesis process of the antiviral drug remdesivir intermediate, the recycling and utilization of alternating titanium condenser and rinsing water is solved, and the overpressure problem caused by volatile solid clogging in the synthesis process is realized, and the recycling and utilization of ammonium chloride and the automation of the system are realized.

CN222872179UActive Publication Date: 2025-05-16HENAN YUCHEN PHARM CO LTD
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Patent Information

Application Number
CN202421676518.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-15
Publication Date
2025-05-16
Estimated Expiration
2034-07-15

AI Technical Summary

Technical Problem

In the synthesis process of the antiviral drug remdesivir intermediate pyrrolo[2,1-F][1,2,4] triazine-4-amine, the volatile solid ammonium chloride easily clogs the condenser, causing overpressure of the reactor, which poses a greater safety risk.

Method used

A system is designed to prevent volatile solids from being blocked in the synthesis process. The system includes a reactor, two titanium condensers and a receiving tank. The condenser is used alternately through the flue gas pipeline and the water inlet pipeline, and the condenser is flushed alternately by the flush water in the receiving tank to prevent clogging.

Benefits of technology

It effectively prevents volatile solids from clogging the condenser, avoids safety problems such as overpressure, and at the same time realizes the recycling of ammonium chloride. The system is simple to operate, with almost no waste gas or waste liquid generation, and the flushing water can be reused, and the amount of water consumed is small, making it easy to achieve industrialization and automation.

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Abstract

The utility model provides a system for preventing volatile solid blockage in a synthesis process. The system comprises a reaction kettle, a first condenser, a second condenser and a receiving tank, the reaction kettle is communicated with the first condenser and the second condenser through a first flue gas pipeline and a second flue gas pipeline, and a first flue gas valve and a second flue gas valve are arranged on the first flue gas pipeline and the second flue gas pipeline. The receiving tank is communicated with water inlets of the first condenser and the second condenser through a first water inlet pipeline and a second water inlet pipeline, and a first water inlet valve and a second water inlet valve are arranged on the first water inlet pipeline and the second water inlet pipeline; water outlets of the first condenser and the second condenser are communicated with the receiving tank through a first water outlet pipeline and a second water outlet pipeline; and a first water outlet valve and a second water outlet valve are arranged on the first water outlet pipeline and the second water outlet pipeline. The system can prevent the problems of overpressure and the like caused by the fact that volatile solids block the condenser.
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