Blood purification pipeline system

Abstract

The utility model discloses a blood purification pipeline system, and relates to the technical field of medical instruments. The blood purification pipeline system comprises an artery pipeline assembly, a vein pipeline assembly, a liquid medicine input pipeline assembly, a dialysate pipeline assembly, a displacement liquid pipeline assembly, a mixed liquid supplementing pipeline assembly, a serosity separation pipeline assembly and a waste liquid pipeline assembly. Through cooperation of the artery pipeline assembly, the vein pipeline assembly and the liquid medicine input pipeline assembly, the treatment mode of artery end and vein end blood circulation can be achieved. The pipeline assembly is matched with a dialysate pipeline assembly, a displacement liquid pipeline assembly, a mixed liquid supplementing pipeline assembly and a waste liquid pipeline assembly, and a treatment mode combining blood circulation and dialysis circulation can be completed; and a plasma separation pipeline assembly is arranged and is matched with a plasma separator and a plasma secondary processor in the filter assembly, so that a treatment mode of combining blood circulation, dialysis circulation and albumin circulation can be completed.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a blood purification pipeline system. Background Art

[0002] Continuous renal replacement therapy (CRRT), also known as continuous blood purification (CBP), is a new blood purification method developed. Initially used to treat acute renal failure (ARF), through continuous research and exploration, its application scope has been extended to severe trauma, sepsis, multiple organ failure, severe heart failure, acute respiratory failure, etc. Recently, it has further developed into an auxiliary treatment for artificial liver support systems, neuroimmune systems, cell purification and other technologies, and has become an important treatment method for the treatment of various critical illnesses.

[0003] Through continuous exploration and development, there are more and more treatment modes for CRRT. Currently, the commonly used treatment modes have developed to more than a dozen, such as CVVH (continuous venovenous hemofiltration), CVVHD (continuous venovenous hemodialysis), CVVHDF (continuous venovenous hemodiafiltration), SCUF (slow continuous ultrafiltration), PE (plasma exchange), SPAD (single pass albumin dialysis), RAD (repeated pass albumin dialysis), PDF (plasma dialysis filtration), HP (hemoperfusion), PA (plasma adsorption), DPP (Double plasma perfusion), DFPP (double filtration plasmapheresis), CPFA (Continuous plasma filtration adsorption), FPSA (fractionated plasma separation and adsorption), CAPS (Continuous albumin purification system), etc. Due to the differences in the principles of different treatment modes, the structures of the required pipelines are quite different, and different matching pipelines are needed to complete the treatment. In clinical actual treatment applications, the same patient needs to undergo multiple treatment modes to complete one treatment cycle. However, the current pipelines cannot support multiple treatment modes with a single set of pipelines, resulting in increased treatment costs, heavy workloads for medical staff, and high learning costs. Summary of the Invention

[0004] The purpose of the present utility model is to provide a blood purification pipeline system that can achieve the switching of multiple different treatment modes, reducing treatment costs, the workload of medical staff, and learning costs.

[0005] To achieve this purpose, the utility model adopts the following technical solutions:

[0006] A blood purification pipeline system for connecting with a blood purification device, the blood purification device including a filter assembly, and the blood purification pipeline system including:

[0007] An arterial pipeline component, one end of which is connected to the human body and the other end is connected to the filter assembly, and the arterial pipeline component is used for drawing out the blood in the human body to the filter assembly;

[0008] A venous pipeline component, one end of which is connected to the filter assembly and the other end is connected to the human body, and is used for transfusing the blood purified by the filter assembly back into the human body;

[0009] A liquid medicine input pipeline component, one end of which is connected to a liquid medicine source and the other end is connected to the arterial pipeline component or the venous pipeline component;

[0010] A dialysate pipeline component, one end of which is connected to a dialysate source and the other end is connected to the filter assembly;

[0011] A replacement fluid pipeline component, one end of which is connected to a replacement fluid source and the other end is connected to the arterial pipeline component or the venous pipeline component;

[0012] A mixed replenishing fluid pipeline component, one end of which is connected to a replenishing fluid source and the other end can selectively be connected to the arterial pipeline component or the venous pipeline component;

[0013] A separated serous fluid pipeline component, the filter assembly including a plasma separator and a plasma secondary processor, one end of the plasma separator is connected to the arterial pipeline component, the other end is connected to the separated serous fluid pipeline component, and after the separated serous fluid pipeline component transports the plasma separated by the plasma separator to the plasma secondary processor, it then transports the plasma processed by the plasma secondary processor to the venous pipeline component;

[0014] A waste liquid pipeline component, one end of which is connected to the filter assembly and the other end is connected to a waste liquid bag.

[0015] As an alternative embodiment of the blood purification tubing system, the plasma separation tubing assembly includes a main plasma separation tubing and a plurality of plasma separation branch tubings with different structures. One end of the main plasma separation tubing is connected to the plasma separator, and the other end is connected to and / or connected to at least one plasma secondary processor with different functions through at least one of the plurality of plasma separation branch tubings with different structures. The plasma secondary processor is connected to the venous tubing assembly through one of the plasma separation branch tubings, or the plasma secondary processor is connected to the venous tubing assembly and the waste liquid tubing assembly respectively through two of the plasma separation branch tubings.

[0016] As an alternative embodiment of the blood purification tubing system, the plurality of plasma separation branch tubings with different structures include a first plasma separation branch tubing and a second plasma separation branch tubing. The plasma secondary processor includes a hemoperfusion cartridge. The plasma separator is connected to the hemoperfusion cartridge through the main plasma separation tubing. The hemoperfusion cartridges are connected through the first plasma separation branch tubing. The hemoperfusion cartridge is connected to the venous tubing assembly through the second plasma separation branch tubing.

[0017] As an alternative embodiment of the blood purification tubing system, the plurality of plasma separation branch tubings with different structures further include a third plasma separation branch tubing and a fourth plasma separation branch tubing. The plasma secondary processor further includes a filter. One end of the main plasma separation tubing is connected to the plasma separator, and the other end is connected to the filter. The filter is connected to the venous tubing assembly through the third plasma separation branch tubing and connected to the waste liquid tubing assembly through the fourth plasma separation branch tubing.

[0018] As an alternative embodiment of the blood purification tubing system, the plurality of plasma separation branch tubings with different structures further include a fifth plasma separation branch tubing. The hemoperfusion cartridge includes a first hemoperfusion cartridge and a second hemoperfusion cartridge. One end of the main plasma separation tubing is connected to the plasma separator, and the other end is connected to the first hemoperfusion cartridge. The first hemoperfusion cartridge and the second hemoperfusion cartridge are connected through the first plasma separation branch tubing. The second hemoperfusion cartridge is connected to the plasma separator through the fifth plasma separation branch tubing. The plasma separator is connected to the filter through the first plasma separation branch tubing. The filter is connected to the venous tubing assembly, the dialysate tubing assembly and the waste liquid tubing assembly respectively.

[0019] As an alternative embodiment of the blood purification tubing system, the fifth plasma separation branch tubing includes a main branch tubing, a first sub-branch tubing and a second sub-branch tubing. Clamps are provided on the main branch tubing, the first sub-branch tubing and the second sub-branch tubing. One end of the main branch tubing is connected to the second hemoperfusion cartridge, and the other end is in communication with both the first sub-branch tubing and the second sub-branch tubing. The first sub-branch tubing is connected to the plasma separator, and the second sub-branch tubing is connected to the waste liquid tubing assembly.

[0020] As an alternative solution of the blood purification pipeline system, the first sub-pipeline is connected to a protein pre-flushing liquid source through a three-way joint.

[0021] As an alternative solution of the blood purification pipeline system, multiple plasma separation sub-pipelines with different structures include a sixth plasma separation sub-pipeline and a seventh plasma separation sub-pipeline. One end of the plasma separation main pipeline is connected to the plasma separator, and the other end is connected to one end of the hemoperfusion cartridge. The other end of the hemoperfusion cartridge is connected to the sixth plasma separation sub-pipeline. The middle parts of the sixth plasma separation sub-pipeline and the seventh plasma separation sub-pipeline are connected, and both ends of the seventh plasma separation sub-pipeline are respectively connected to the plasma separator and the filter.

[0022] As an alternative solution of the blood purification pipeline system, the liquid medicine input pipeline assembly includes a pre-infusion pipeline assembly, and the pre-infusion pipeline assembly is connected to the arterial pipeline assembly for supplementing liquid medicine.

[0023] As an alternative solution of the blood purification pipeline system, the liquid medicine input pipeline assembly further includes a first anticoagulant liquid medicine pipeline assembly and a second anticoagulant liquid medicine pipeline assembly. The first anticoagulant liquid medicine pipeline assembly can be connected to the venous pipeline assembly for supplementing the first anticoagulant liquid medicine; the second anticoagulant liquid medicine pipeline assembly can be connected to the arterial pipeline assembly for supplementing the second anticoagulant liquid medicine; one of the first anticoagulant liquid medicine pipeline assembly and the second anticoagulant liquid medicine pipeline assembly is selected for use.

[0024] As an alternative solution of the blood purification pipeline system, a first three-way one-way valve is arranged at one end of the venous pipeline assembly close to the connection with the human body. The first anticoagulant liquid medicine pipeline assembly is connected to the first three-way one-way valve, and the first three-way one-way valve is used for the one-way conduction of the first anticoagulant liquid medicine pipeline assembly to the venous pipeline assembly.

[0025] As an alternative solution of the blood purification pipeline system, the blood purification pipeline system further includes an integration tray. A plurality of pipeline installation positions and a plurality of pipeline guiding positions are arranged on the integration tray. The plurality of pipeline installation positions are arranged at intervals along the circumferential direction of the integration tray, and the pipeline guiding positions are arranged below the pipeline installation positions;

[0026] The arterial pipeline assembly, the pre-infusion pipeline assembly, the replacement fluid pipeline assembly, the dialysate pipeline assembly, the plasma separation fluid pipeline assembly, the mixed infusion pipeline assembly and the waste fluid pipeline assembly are sequentially fixed to the pipeline installation positions along the circumferential direction of the integration tray, and the first anticoagulant liquid medicine pipeline assembly and the second anticoagulant liquid medicine pipeline assembly are fixed to the pipeline guiding positions.

[0027] As an alternative embodiment of the blood purification tubing system, the blood purification device further includes two tubing selectors. Two tubing selector fixing positions are provided on the integrated tray, and the two tubing selectors are respectively fixed to the two tubing selector fixing positions.

[0028] The replacement fluid tubing assembly includes a pre-replacement fluid branch tubing and a post-replacement fluid branch tubing. The pre-replacement fluid branch tubing is connected to the arterial tubing assembly, and the post-replacement fluid branch tubing is connected to the venous tubing assembly. One of the tubing selectors can selectively open the pre-replacement fluid branch tubing or the post-replacement fluid branch tubing.

[0029] The mixed replenishing fluid tubing assembly includes a pre-replenishing fluid branch tubing and a post-replenishing fluid branch tubing. The pre-replenishing fluid branch tubing is connected to the arterial tubing assembly, and the post-replenishing fluid branch tubing is connected to the venous tubing assembly. The other tubing selector can selectively open the pre-replenishing fluid branch tubing or the post-replenishing fluid branch tubing.

[0030] As an alternative embodiment of the blood purification tubing system, the venous tubing assembly includes a venous chamber. A fluid splitter is provided in the venous chamber. The fluid splitter divides the inner cavity of the venous chamber into a first chamber, a second chamber, and a third chamber. The fluid splitter includes a buffer portion and a bearing portion. An inlet, an outlet, and a liquid replenishing inlet are provided on the venous chamber. The outlet is provided at one end of the venous chamber. A first chamber is formed between the outlet and the bearing portion. A second chamber is formed between the bearing portion and the buffer portion. The inlet is communicated with the first chamber or the second chamber. A third chamber is formed between the buffer portion and the other end of the venous chamber. The liquid replenishing inlet is communicated with the third chamber. The buffer portion is used to buffer the impact force of the liquid replenished from the liquid replenishing inlet entering the second chamber. The bearing portion is connected to the inner wall of the venous chamber, and both the bearing portion and the buffer portion are provided with communication structures to communicate the first chamber, the second chamber, and the third chamber.

[0031] As an alternative embodiment of the blood purification tubing system, heating bladders are provided on the dialysate tubing assembly, the sub-solution tubing assembly, and the replacement fluid tubing assembly.

[0032] As an alternative embodiment of the blood purification tubing system, the blood purification tubing system further includes a priming tubing assembly. The priming tubing assembly includes a priming main tubing and a plurality of priming branch tubings communicated with the priming main tubing. The priming main tubing is connected to a priming fluid source. The plurality of priming branch tubings are respectively connected to the arterial tubing assembly, the drug infusion tubing assembly, and the mixed replenishing fluid tubing assembly. The venous tubing assembly is connected to a waste liquid bag.

[0033] Alternatively, the pre-flushing main pipeline is connected to a pre-flushing liquid source, and multiple pre-flushing branch pipelines are respectively connected to the arterial pipeline assembly, the medicine liquid input pipeline assembly, the mixed replenishing liquid pipeline assembly, and the venous pipeline assembly.

[0034] As an alternative solution of the blood purification pipeline system, pressure sensors are provided at both ends where the plasma separation main pipeline is connected to the plasma separator and where the plasma separation main pipeline is connected to the plasma secondary processor.

[0035] As an alternative solution of the blood purification pipeline system, for the dialysate pipeline assembly, two dialysate branch pipelines are provided at the end of the dialysate pipeline assembly far from the connection with the dialysate source. One of the dialysate branch pipelines is connected to the filter assembly, and the other dialysate branch pipeline is used to supplement treatment medicine liquid.

[0036] Advantages of the present utility model:

[0037] The blood purification pipeline system provided by the present utility model can achieve a treatment mode of blood circulation at the arterial end and the venous end through the cooperation of the arterial pipeline assembly, the venous pipeline assembly, and the medicine liquid input pipeline assembly; through the cooperation of the arterial pipeline assembly, the medicine liquid input pipeline assembly, and the venous pipeline assembly with the dialysate pipeline assembly, the replacement liquid pipeline assembly, the mixed replenishing liquid pipeline assembly, and the waste liquid pipeline assembly, a treatment mode combining blood circulation and dialysis circulation can be completed; by further setting a plasma separation pipeline assembly and cooperating with the plasma separator and the plasma secondary processor in the filter assembly, a treatment mode combining blood circulation, dialysis circulation, and albumin circulation can be completed. This blood purification pipeline system can support multiple different treatment modes and support the switching of common treatment modes during the treatment process, which is not only convenient for clinical use, reduces the workload and learning cost of medical staff, but also greatly reduces the treatment cost of patients.

[0038] Through the integrated disk, the integration and orderly fixation of each pipeline assembly are realized. During clinical operation, only need to fix the integrated disk on the blood purification device, and then connect each pipeline assembly to the blood purification device one by one, without the need for medical staff to connect and install each pipeline assembly again, which greatly simplifies the installation steps, is easy to operate, and even inexperienced personnel can operate, reducing the workload and learning cost of medical staff. Description of the Drawings

[0039] Figure 1 is a schematic structural diagram of the blood purification pipeline system provided by an embodiment of the present utility model;

[0040] Figure 2 is a schematic structural diagram of the integrated disk provided by an embodiment of the present utility model;

[0041] Figure 3It is the top view of the integrated tray provided by the embodiment of the present utility model;

[0042] Figure 4 It is the bottom view of the integrated tray provided by the embodiment of the present utility model;

[0043] Figure 5 It is the structural schematic diagram of the drip chamber provided by the embodiment of the present utility model;

[0044] Figure 6 It is the cross-sectional view of the drip chamber provided by the embodiment of the present utility model;

[0045] Figure 7 It is the exploded view of the drip chamber provided by the embodiment of the present utility model.

[0046] In the figure:

[0047] 100, clip; 200, Luer connector; 300, plug; 400, needle; 500, Hansen connector; 600, three-way joint; 700, pressure sensor; 800, heating bladder; 900, four-way joint;

[0048] 1, arterial pipeline assembly; 11, arterial pump tube; 12, main arterial pipeline; 13, arterial branch pipeline;

[0049] 2, medicine liquid input pipeline assembly; 21, front replenishing liquid pipeline assembly; 22, second anticoagulant medicine liquid pipeline assembly; 23, first anticoagulant medicine liquid pipeline assembly;

[0050] 3, venous pipeline assembly; 31, drip chamber; 311, liquid inlet; 312, liquid outlet; 313, liquid replenishing port; 314, splitter; 3141, buffer part; 3142, bearing part; 3143, connecting part; 315, first chamber; 316, second chamber; 317, third chamber; 318, connection port; 319, filter element; 32, drip chamber inlet tube; 33, liquid replenishing pipeline; 34, drip chamber outlet tube; 341, first three-way one-way valve; 35, drip chamber branch pipeline; 36, venous pressure sensor;

[0051] 4, plasma separation pipeline assembly; 41, main plasma separation pipeline; 42, first plasma separation branch pipeline; 43, second plasma separation branch pipeline; 44, third plasma separation branch pipeline; 45, fourth plasma separation branch pipeline; 46, fifth plasma separation branch pipeline; 461, main branch pipeline; 462, first sub-branch pipeline; 463, second sub-branch pipeline; 47, sixth plasma separation branch pipeline; 48, seventh plasma separation branch pipeline;

[0052] 5, integrated tray; 51, pipeline installation position; 511, installation hole; 512, positioning groove; 513, first emergency hole; 52, guiding groove; 53, position mark; 54, pipeline selector fixing position; 541, perforation; 542, second emergency hole;

[0053] 6. Dialysate pipeline assembly; 61. Dialysate branch pipeline

[0054] 7. Replacement fluid pipeline assembly; 71. Front replacement fluid branch pipeline; 72. Rear replacement fluid branch pipeline

[0055] 8. Mixed replenishment fluid pipeline assembly; 81. Front replenishment fluid branch pipeline; 82. Rear replenishment fluid branch pipeline

[0056] 9. Waste liquid bag; 91. Waste liquid inlet branch

[0057] 10. Priming pipeline assembly; 101. Priming main pipeline; 102. Priming branch pipeline

[0058] 110. Waste liquid pipeline assembly; 1101. Waste liquid outlet branch; 1102. Waste liquid bypass Detailed implementation manners

[0059] To make the technical problems solved by the present utility model, the technical solutions adopted and the achieved technical effects clearer, the technical solutions of the present utility model will be further described below with reference to the drawings and through specific implementation manners.

[0060] In the description of the present utility model, unless otherwise clearly specified and defined, the terms "connected", "connected to", and "fixed" shall be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be a mechanical connection or an electrical connection; it may be directly connected or indirectly connected through an intermediate medium, and it may be the internal communication of two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0061] The blood purification pipeline system provided in this embodiment is used to connect a blood purification device to a human body, so as to draw the blood in the human body to a filter assembly in the blood purification device, remove pathogenic sources, water, toxic substances, metabolic wastes, etc. from the blood through the filter assembly, and then return the blood purified by the filter assembly to the human body. According to the analysis of the blood purification treatment principle and clinical actual use, the blood purification treatment modes include the treatment modes of single-circulation systems, and the treatment modes of double-circulation systems and above systems. Due to the differences in the principles of different treatment modes, the structures of the required pipelines are different, and different types of supporting pipeline systems are required to complete the treatment. In clinical actual treatment applications, the same patient needs to undergo multiple treatment modes to complete a treatment cycle. In order to reduce the treatment cost of patients, the workload of medical staff, and the learning cost, the blood purification pipeline system provided in this embodiment is used for treatment modes of double-circulation systems and above, and can not only meet the treatment modes of single-circulation systems related to hemoperfusion and hemoperfusion, as well as treatment modes that require the combination of blood circulation and dialysis circulation, such as continuous venovenous hemofiltration, continuous venovenous hemodialysis, continuous venovenous hemodiafiltration, slow continuous ultrafiltration, single plasma exchange therapy, repeated albumin dialysis, single-pass albumin dialysis, plasma diafiltration, etc.; but also can complete treatment modes that require the combination of blood circulation, dialysis circulation, and albumin circulation, such as plasma adsorption, plasma perfusion, double plasma perfusion, double filtration plasma exchange, continuous plasma filtration adsorption, partial plasma separation adsorption, CAPS continuous albumin purification system, etc.

[0062] As Figure 1 shown, the blood purification pipeline system provided in this embodiment includes an arterial pipeline assembly 1, a medicine infusion pipeline assembly 2, a venous pipeline assembly 3, a dialysate pipeline assembly 6, a replacement fluid pipeline assembly 7, a mixed replenishment fluid pipeline assembly 8, a plasma separation pipeline assembly 4, and a waste liquid pipeline assembly 110.

[0063] One end of the arterial pipeline assembly 1 is connected to the human body, and the other end is connected to the filter assembly. The arterial pipeline assembly 1 is used to draw the blood in the human body to the filter assembly. One end of the medicine infusion pipeline assembly 2 is connected to a medicine source, and the other end is connected to the arterial pipeline assembly 1 or the venous pipeline assembly 3. Specifically, the medicine infusion pipeline assembly 2 includes a pre-replenishment fluid pipeline assembly 21, and the pre-replenishment fluid pipeline assembly 21 is connected to the arterial pipeline assembly 1 and is used to supplement medicine. The pre-replenishment fluid pipeline assembly 21 can be flexibly applied to the anticoagulation system or can be used independently for fluid replenishment. When the pre-replenishment fluid pipeline assembly 21 is applied to the anticoagulation system, the medicine is citric acid.

[0064] The liquid medicine input pipeline assembly 2 further includes a first anticoagulant liquid medicine pipeline assembly 23 and a second anticoagulant liquid medicine pipeline assembly 22. The first anticoagulant liquid medicine pipeline assembly 23 can be connected to the venous pipeline assembly 3 for supplementing the first anticoagulant liquid medicine. The second anticoagulant liquid medicine pipeline assembly 22 can be connected to the arterial pipeline assembly 1 for supplementing the second anticoagulant liquid medicine. One of the first anticoagulant liquid medicine pipeline assembly 23 and the second anticoagulant liquid medicine pipeline assembly 22 is selected for use. The first anticoagulant liquid medicine pipeline assembly 23 and the venous pipeline assembly 3 are designed to be separable, and this separable design facilitates the discharge of gas in the first anticoagulant liquid medicine pipeline assembly 23.

[0065] Further, a first three-way one-way valve 341 is provided at one end of the venous pipeline assembly 3 close to the connection with the human body. The first anticoagulant liquid medicine pipeline assembly 23 is connected to the first three-way one-way valve 341, and the first three-way one-way valve 341 is used for the one-way conduction of the first anticoagulant liquid medicine pipeline assembly 23 to the venous pipeline assembly 3. By setting the first three-way one-way valve 341 to connect the first anticoagulant liquid medicine pipeline assembly 23, only the liquid in the first anticoagulant liquid medicine pipeline assembly 23 is allowed to flow into the venous pipeline assembly 3, and the liquid in the venous pipeline assembly 3 cannot flow out through the first three-way one-way valve 341, ensuring safety during actual use. A one-way valve is provided at one end of the second anticoagulant liquid medicine pipeline assembly 22 connected to the second anticoagulant liquid medicine source, and this one-way valve can block the liquid in the arterial pipeline assembly 1 from flowing into the second anticoagulant liquid medicine pipeline assembly 22.

[0066] In this embodiment, the first anticoagulant liquid medicine includes calcium agent or anticoagulant antagonist, and the second anticoagulant liquid medicine includes heparin. The first anticoagulant liquid medicine pipeline assembly 23 and the second anticoagulant liquid medicine pipeline assembly 22 share a pump head, and this pump head can selectively drive the liquid medicine in the first anticoagulant liquid medicine pipeline assembly 23 or the liquid medicine in the second anticoagulant liquid medicine pipeline assembly 22. Citric acid is supplemented in the pre-infusion pipeline assembly 21 and is used in combination with the calcium agent in the first anticoagulant liquid medicine pipeline assembly 23 for anticoagulation. The heparin in the second anticoagulant liquid medicine pipeline assembly 22 can be used alone for anticoagulation.

[0067] One end of the dialysate pipeline assembly 6 is connected to the dialysate source, and the other end is connected to the filter assembly. One end of the replacement fluid pipeline assembly 7 is connected to the replacement fluid source, and the other end of the replacement fluid pipeline assembly 7 is connected to the arterial pipeline assembly 1 or the venous pipeline assembly 3. One end of the mixed replenishing fluid pipeline assembly 8 is connected to the replenishing fluid source, and the other end can be selectively connected to the arterial pipeline assembly 1 or the venous pipeline assembly 3. The filter assembly includes a plasma separator and a plasma secondary processor. One end of the plasma separator is connected to the arterial pipeline assembly 1, and the other end is connected to the separated plasma pipeline assembly 4. After the separated plasma pipeline assembly 4 transports the plasma separated by the plasma separator to the plasma secondary processor, it then transports the plasma processed by the plasma secondary processor to the venous pipeline assembly 3. One end of the waste liquid pipeline assembly 110 is connected to the filter assembly, and the other end is connected to the waste liquid bag 9.

[0068] Through the cooperation of the arterial pipeline assembly 1, the medicine infusion pipeline assembly 2, and the venous pipeline assembly 3, a treatment mode of blood circulation at the arterial end and the venous end can be achieved; the arterial pipeline assembly 1, the medicine infusion pipeline assembly 2, and the venous pipeline assembly 3 cooperate with the dialysate pipeline assembly 6, the replacement fluid pipeline assembly 7, the mixed replenishing fluid pipeline assembly 8, and the waste liquid pipeline assembly 110 to complete a treatment mode combining blood circulation and dialysis circulation; by further setting the separated plasma pipeline assembly 4 and cooperating with the plasma separator and the plasma secondary processor in the filter assembly, a treatment mode combining blood circulation, dialysis circulation, and albumin circulation can be completed. This blood purification pipeline system can support a variety of different treatment modes and support the switching of common treatment modes during the treatment process, which is not only convenient for clinical use, reduces the workload and learning cost of medical staff, but also greatly reduces the treatment cost of patients.

[0069] The blood purification pipeline system further includes an integration tray 5. A plurality of pipeline installation positions 51 and a plurality of pipeline guiding positions are provided on the integration tray 5. The plurality of pipeline installation positions 51 are arranged at intervals along the circumferential direction of the integration tray 5, and the pipeline guiding positions are arranged below the pipeline installation positions 51. The arterial pipeline assembly 1, the front replenishing fluid pipeline assembly 21, the replacement fluid pipeline assembly 7, the dialysate pipeline assembly 6, the separated plasma pipeline assembly 4, the mixed replenishing fluid pipeline assembly 8, and the waste liquid pipeline assembly 110 are sequentially fixed to the pipeline installation positions 51 along the circumferential direction of the integration tray 5, and the first anticoagulant medicine pipeline assembly 23 and the second anticoagulant medicine pipeline assembly 22 are fixed to the pipeline guiding positions. The venous pipeline assembly 3 is arranged on one side of the integration tray 5, with one end connected to the outlet of the filter assembly and the other end connected to the human body.

[0070] Specifically, as Figures 2 - 4As shown, the integrated plate 5 includes a bottom plate and side plates surrounding the circumference of the bottom plate. A plurality of pipeline installation positions 51 are provided on the side plates, and a plurality of pipeline components are respectively installed in the pipeline installation positions 51. Each pipeline installation position 51 is provided with a position identifier 53 corresponding to the type of pipeline component. In this embodiment, the position identifier 53 includes graphic symbols such as "△", "□", "◎", etc. Different graphic symbols represent different types of pipeline components. When medical staff connect the pipeline components to the blood purification equipment and the human body, they only need to identify the types of pipeline components according to the position identifier 53, reducing the risk of incorrect installation of different types of pipeline components.

[0071] The pipeline installation position 51 includes two installation holes 511 arranged at intervals. The two ends of the pipeline component fixed to the pipeline installation position 51 respectively pass through the two installation holes 511 of its respective pipeline installation position 51. The installation holes 511 are arranged on the side plate, and a positioning groove 512 is also arranged between the two installation holes 511. The blood purification equipment also includes pump heads for each pipeline component, and the positioning groove 512 is used to position the pump heads. Exemplarily, the arterial pipeline component 1 includes an arterial pipeline, various fittings, connectors or plugs 300, etc. The arterial pipeline includes an arterial pump tube 11 and two arterial main pipelines 12. The arterial pump tube 11 surrounds the circumference of the pump head of the arterial pipeline component 1. The rotation of the pump head of the arterial pipeline component 1 drives the liquid in the arterial pump tube 11 to flow, providing power for the liquid flow in the arterial pipeline. The two ends of the arterial pump tube 11 are respectively connected to one end of the two installation holes 511, and the other ends of the two installation holes 511 are respectively connected to the two arterial main pipelines 12. The arterial main pipelines 12 are arranged outside the side plate, so that the length of the arterial main pipelines 12 is not limited, and it is more convenient to connect the arterial main pipelines 12 to the blood purification equipment and the human body. Regarding the specific connection method of other pipeline components fixed to the pipeline installation position 51 and the pipeline installation position 51, it is the same as the installation method of the arterial pipeline component 1 and will not be elaborated here.

[0072] The integrated plate 5 further includes a reinforcing plate. The reinforcing plate is arranged on the circumference of the side plate and is perpendicular to the side plate. The installation hole 511 extends from the side plate to the end of the reinforcing plate away from the side plate. In order to ensure the reliability of the connection between the arterial pump tube 11 and the arterial main pipeline 12, the installation hole 511 needs to have a certain extension length. By providing a reinforcing plate perpendicular to the side plate, the installation hole 511 extends in the width direction of the reinforcing plate from the side plate.

[0073] Furthermore, the pipeline installation position 51 further includes a first emergency hole 513. The first emergency hole 513 is arranged on the bottom plate and corresponds to the central hole of the pump head. When the blood purification equipment is powered off, a wrench can be used to pass through the first emergency hole 513 and cooperate with the central hole of the pump head to drive the pump head to rotate.

[0074] The pipeline guiding positions include a plurality of guiding grooves 52, and the second anticoagulant liquid medicine pipeline assembly 22 and the first anticoagulant liquid medicine pipeline assembly 23 are guided and fixed through the guiding grooves 52. In this embodiment, a plurality of pipeline guiding positions are spaced below the reinforcing plate. Each pipeline guiding position includes a plurality of guiding grooves 52, and the guiding grooves 52 are used to guide and fix the second anticoagulant liquid medicine pipeline assembly 22 and the first anticoagulant liquid medicine pipeline assembly 23. The guiding grooves 52 are arranged as semi-circular grooves with the notch facing upwards and / or downwards, which is more convenient for fixing the second anticoagulant liquid medicine pipeline assembly 22 and the first anticoagulant liquid medicine pipeline assembly 23.

[0075] Further, with continued reference to Figure 1 and Figure 2 , the blood purification device further includes two pipeline selectors. Two pipeline selector fixing positions 54 are provided on the integrated disc 5, and the two pipeline selectors are respectively fixed on the two pipeline selector fixing positions 54. The replacement fluid pipeline assembly 7 includes a front replacement fluid branch pipeline 71 and a rear replacement fluid branch pipeline 72. The front replacement fluid branch pipeline 71 is connected to the arterial pipeline assembly 1, and the rear replacement fluid branch pipeline 72 is connected to the venous pipeline assembly 3. One of the pipeline selectors can selectively open the front replacement fluid branch pipeline 71 or the rear replacement fluid branch pipeline 72. The mixed replenishing fluid pipeline assembly 8 includes a front replenishing fluid branch pipeline 81 and a rear replenishing fluid branch pipeline 82. The front replenishing fluid branch pipeline 81 is connected to the arterial pipeline assembly 1, and the rear replenishing fluid branch pipeline 82 is connected to the venous pipeline assembly 3. The other pipeline selector can selectively open the front replenishing fluid branch pipeline 81 or the rear replenishing fluid branch pipeline 82. When the treatment mode in clinical use requires the use of the replacement fluid base solution, sodium bicarbonate injection needs to be supplemented, and it can meet the requirements according to the drug instructions of the replacement fluid base solution and the recommendations of clinical experts, so that the sodium bicarbonate injection can be supplemented on the same side and in the same proportion as the replacement fluid base solution.

[0076] Specifically, the fixed position 54 of the pipeline selector includes an installation groove. The pipeline selector is installed in the installation groove. Two through holes 541 are spaced apart on both opposite side walls of the installation groove. The two through holes 541 on one side wall and the two through holes 541 on the other side wall are arranged in one-to-one correspondence. The pipeline selector includes a selection rod and two clamping plates. The selection rod is located between the two clamping plates. The pipeline selector selectively opens the front replacement liquid branch pipeline 71 and the rear replacement liquid branch pipeline 72. The front replacement liquid branch pipeline 71 and the rear replacement liquid branch pipeline 72 respectively pass through the two through holes 541 on one side wall and then respectively pass through the two through holes 541 on the other side wall. The front replacement liquid branch pipeline 71 is located between one clamping plate and the selection rod, and the rear replacement liquid branch pipeline 72 is located between the other clamping plate and the selection rod. The selection rod can selectively move towards the direction close to one of the two clamping plates to close one of the front replacement liquid branch pipeline 71 and the rear replacement liquid branch pipeline 72, so that the other branch pipeline is opened. Regarding the connection mode of the front replenishing liquid branch pipeline 81 and the rear replenishing liquid branch pipeline 82 with the pipeline selector and the principle of the control switch, it is the same as the connection mode of the front replacement liquid branch pipeline 71 and the rear replacement liquid branch pipeline 72 with the pipeline selector and the principle of the control switch, and will not be elaborated here.

[0077] A second emergency hole 542 is further provided at the bottom of the installation groove. When the blood purification device is powered off, the position of the selection rod can be adjusted through the second emergency hole 542.

[0078] On the integrated tray 5 provided in this embodiment, there are seven pipeline installation positions 51. Three pipeline installation positions 51 are provided on each of the two side plates extending along the length direction of the integrated tray 5. Among them, the three pipeline installation positions 51 on one side plate are respectively installed with the pre-rehydration pipeline assembly 21, the replacement fluid pipeline assembly 7, and the dialysis fluid pipeline assembly 6. The three pipeline installation positions 51 on the other side plate are respectively the waste fluid pipeline assembly 110, the mixed rehydration pipeline assembly 8, and the sub-slurry pipeline assembly 4. Among them, the pre-rehydration pipeline assembly 21 and the waste fluid pipeline assembly 110 are arranged oppositely, the replacement fluid pipeline assembly 7 and the mixed rehydration pipeline assembly 8 are arranged oppositely, and the dialysis fluid pipeline assembly 6 and the sub-slurry pipeline assembly 4 are arranged oppositely. One pipeline installation position 51 is provided on one of the side plates extending along the width direction of the integrated tray 5, and this pipeline installation position 51 is used to install the arterial pipeline assembly 1; on the other side plate, there is a pipeline selector fixing position 54, and this pipeline selector fixing position 54 is used to install a pipeline selector for controlling the selective connection of the replacement fluid pipeline assembly 7 with the arterial pipeline assembly 1 or the venous pipeline assembly 3. On the outer side of the side plate of the pipeline installation position 51 where the mixed rehydration pipeline assembly 8 is installed, there is another pipeline selector fixing position 54, and this pipeline selector fixing position 54 is used to install a pipeline selector for controlling the selective connection of the mixed rehydration pipeline assembly 8 with the arterial pipeline assembly 1 or the venous pipeline assembly 3. The first anticoagulant drug solution pipeline assembly 23 and the second anticoagulant drug solution pipeline assembly 22 are arranged in the guiding groove 52 on the outer periphery of the side plate where the pipeline installation position 51 of the pre-rehydration pipeline assembly 21 is located, so as to guide the first anticoagulant drug solution pipeline assembly 23 to be connected to one end with the venous pipeline assembly 3.

[0079] This blood purification pipeline system realizes the integration and orderly fixation of each pipeline component through the integrated tray 5. During clinical operation, only need to fix the integrated tray 5 on the blood purification equipment, and then connect each pipeline component to the blood purification equipment and the human body one by one. There is no need for medical staff to connect and install each pipeline component again, which greatly simplifies the installation steps, is easy to operate, and even inexperienced personnel can operate, reducing the workload and learning cost of medical staff.

[0080] Specifically, two three-way joints 600 are provided on the arterial main pipeline 12 connected to the human body. One end of the pre-rehydration pipeline assembly 21 is connected to the arterial main pipeline 12 connected to the human body through a three-way joint 600, and the other end is connected to the citric acid source. A four-way joint 900 is provided on the arterial main pipeline 12 connected to the filter assembly. One end of the second anticoagulant drug solution pipeline assembly 22 is connected to the arterial main pipeline 12 connected to the filter assembly, and the other end is connected to the heparin source for supplementing heparin. The other interfaces of the other three-way joint 600 and the four-way joint 900 are also connected to an arterial branch pipeline 13, and the arterial branch pipeline 13 is used to connect to the pre-replacement fluid branch pipeline 71.

[0081] In the prior art, in the blood purification pipeline system for hemoperfusion treatment, an arterial pot is provided in the arterial pipeline assembly 1. Usually, blood contacts air in the arterial pot, which easily generates bubbles and poses risks of air embolism and blood coagulation. In the blood purification pipeline system provided in this embodiment, the design of the arterial pot is cancelled in the arterial pipeline assembly 1, reducing the overall blood volume in the arterial pipeline assembly 1 and also reducing the chance of blood contacting air, thereby reducing the risk of blood coagulation.

[0082] At the same time, the volume of the venous pot 31 in the venous pipeline assembly 3 in the prior art is too large. Improper design easily causes blood impact to form bubbles, and there are dead spaces when the liquid flows in the venous pot 31, which easily leads to blood coagulation.

[0083] To solve the problem of the liquid dead space in the venous pot 31 and reduce the risk of blood coagulation, as Figure 1 、 Figures 5 - 7 shown, the venous pipeline assembly 3 provided in this embodiment includes a venous pot 31. A fluid splitter 314 and a filter element 319 are provided in the venous pot 31. The fluid splitter 314 divides the inner cavity of the venous pot 31 into a first chamber 315, a second chamber 316 and a third chamber 317. The fluid splitter 314 includes a buffer portion 3141 and a bearing portion 3142. An inlet 311, an outlet 312 and a liquid replenishment port 313 are provided on the venous pot 31. The outlet 312 is provided at one end of the venous pot 31. A first chamber 315 is formed between the outlet 312 and the bearing portion 3142. The filter element 319 is provided in the first chamber 315 and is used for filtering the blood entering the human body. A second chamber 316 is formed between the bearing portion 3142 and the buffer portion 3141. The inlet 311 communicates with the first chamber 315 or the second chamber 316. A third chamber 317 is formed between the buffer portion 3141 and the other end of the venous pot 31. The liquid replenishment port 313 communicates with the third chamber 317. The buffer portion 3141 is used for buffering the impact force of the liquid replenished from the liquid replenishment port 313 entering the second chamber 316. The bearing portion 3142 is connected to the inner wall of the venous pot 31, and both the bearing portion 3142 and the buffer portion 3141 are provided with communication structures to enable the first chamber 315, the second chamber 316 and the third chamber 317 to communicate. During blood purification treatment, blood enters the second chamber 316 from the inlet 311. The second chamber 316 is located between the first chamber 315 and the third chamber 317 and has no dead corners, and the blood flows fully in the second chamber 316. The replenished liquid entering the third chamber 317 through the liquid replenishment port 313 enters the second chamber 316 through the buffer portion 3141 and the communication structure after being buffered by the buffer portion 3141. The setting of the buffer portion 3141 reduces the impact of the replenished liquid on the blood, enabling the replenished liquid to be evenly dispersed and flow onto the blood in the second chamber 316 to form a liquid layer, effectively isolating air and blood, and greatly reducing the risk of blood coagulation in the venous pot 31.

[0084] In this embodiment, the liquid inlet 311 communicates with the second chamber 316. In other embodiments, the liquid inlet 311 may also communicate with the first chamber 315. With such an arrangement, blood directly enters the first chamber 315 through the liquid inlet 311, reducing the flow resistance of the blood and also avoiding the formation of dead space.

[0085] The venous line assembly 3 further includes a venous burette inlet tube 32, a liquid replenishment line 33, and a venous burette outlet tube 34. One end of the venous burette inlet tube 32 is connected to the liquid inlet 311, and the other end is connected to the outlet of the filter assembly to deliver the blood purified by the filter assembly to the second chamber 316 of the venous burette 31. One end of the liquid replenishment line 33 is connected to the liquid replenishment port 313, and the other end is connected to a liquid replenishment source to allow the liquid in the liquid replenishment source to enter the third chamber 317 through the liquid replenishment line 33. One end of the venous burette outlet tube 34 is connected to the outlet 312, and the other end is connected to the human body to transfuse the blood passing through the venous burette 31 back to the human body. A three-way joint 600 is provided on the venous burette outlet tube 34 of the venous line assembly 3, and the venous burette outlet tube 34 is connected to the first anticoagulant drug line assembly 23 through the three-way joint 600. Accessories such as clips 100, Luer connectors 200, and plugs 300 are also provided on the venous burette inlet tube 32, the liquid replenishment line 33, and the venous burette outlet tube 34. The switch of the line is controlled by the clip 100, and plugs 300 are provided at the end of the venous burette inlet tube 32 away from the liquid inlet 311, the end of the liquid replenishment line 33 away from the liquid replenishment port 313, and the end of the venous burette outlet tube 34 away from the outlet 312. The Luer connector 200 is used to connect components such as syringes, infusion sets, or sensors. When the venous burette inlet tube 32 is not connected to the outlet of the filter assembly, the liquid replenishment line 33 is not connected to the liquid replenishment source, and the venous burette outlet tube 34 is not connected to the human body, they are blocked by the plugs 300 to prevent external dust or impurities from entering the line.

[0086] Two connection ports 318 are further provided at one end of the venous burette 31 away from the outlet 312. Each of the two connection ports 318 is connected to a venous burette branch line 35. A venous pressure sensor 36 is connected to one of the venous burette branch lines 35. The venous pressure sensor 36 is used to monitor the pressure condition in the venous burette 31, and further judge the liquid flow condition in the venous burette 31 through the pressure in the venous burette 31. The other venous burette branch line 35 is used to connect a syringe or an infusion set. Clips 100, Luer connectors 200, and plugs 300 are also provided on each venous burette branch line 35.

[0087] Specifically, the fluid divider 314 further includes a connecting portion 3143. One side of the buffer portion 3141 and the bearing portion 3142 close to each other is set as a plane. The connecting portion 3143 is used to connect the buffer portion 3141 and the bearing portion 3142. The connecting portion 3143 is set as a columnar body. The two ends of the columnar connecting portion 3143 are smoothly connected to the centers of the two planes respectively, reducing the dead space in the second chamber 316, and the connecting portion 3143 occupies a relatively small volume of the second chamber 316, making it more convenient for blood to flow fully in the second chamber 316.

[0088] Further, the venous chamber 31 is set as a shuttle shape. The circumferential diameters at both ends of the shuttle-shaped venous chamber 31 are smaller, and the circumferential diameter at the middle position is larger, facilitating the full flow of the blood entering the second chamber 316 from the liquid inlet 311 in the second chamber 316 without forming a dead space.

[0089] Specifically, the communication structure includes a communication ring. The buffer portion 3141 is set as a conical shape. The top of the conical buffer portion 3141 faces the third chamber 317, and a communication ring is formed between the bottom and the inner wall of the venous chamber 31. The liquid entering the third chamber 317 through the liquid filling port 313 flows from the top to the bottom of the buffer portion 3141 to the communication ring. Since the third chamber 317 gradually contracts from the position close to the buffer portion 3141 to the position far from the buffer portion 3141, the liquid filling port 313 is arranged at a position of the third chamber 317 far from the buffer portion 3141. The replenishing liquid entering the third chamber 317 through the liquid filling port 313 slowly flows down along the conical surface of the conical buffer portion 3141, and is dispersed along the circumferential direction of the buffer portion 3141 during the downward flow until it flows to the communication ring and enters the second chamber 316. The kinetic energy of the replenishing liquid is relatively small compared with flowing vertically downward, and it is uniformly dispersed on the blood to form a liquid layer, effectively separating air and blood, thus reducing the impact on the blood in the second chamber 316, reducing the formation of bubbles, and further reducing the risk of blood coagulation.

[0090] Of course, in other embodiments, the buffer portion 3141 may also be set as other buffer structures such as a spherical body.

[0091] Further, the connection structure further includes connection holes. The bearing part 3142 is provided with inner grooves at intervals along the outer periphery of the bearing part 3142. The connection holes are formed between the inner grooves and the inner wall of the drip chamber 31. The convex parts formed between adjacent inner grooves are connected to the inner wall of the drip chamber 31. The distribution fluid body 314 is fixed in the accommodation cavity through the bearing part 3142. In order to realize the connection between the distribution fluid body 314 and the drip chamber 31 and enable the liquid to flow into the first chamber 315 through the second chamber 316, the convex part on the outer periphery of the bearing part 3142 is connected with the inner wall of the drip chamber 31 by interference fit connection or other methods such as gluing. The liquid flows to the first chamber 315 through the connection holes. The multiple connection holes in the circumferential direction of the bearing part 3142 enable the replacement fluid and blood to flow into the first chamber 315 through the multiple connection holes, preventing dead spaces and further reducing the risk of blood coagulation. Of course, in other embodiments, the connection holes can also be directly provided on the plane of the bearing part 3142, and the entire outer periphery of the bearing part 3142 is connected with the inner wall of the drip chamber 31 in a matching manner.

[0092] In this embodiment, one end of the bearing part 3142 close to the first chamber 315 is arranged in a conical structure. This conical structure can guide the liquid entering the first chamber 315 to gradually flow downward from the circumferential direction of the bearing part 3142 to a position closer to the center and then flow to the filter element 319. The filter element 319 is also arranged in a conical shape, and the small end of the conical filter element 319 is arranged close to the small end of the conical structure, which can prevent blood from accumulating in the middle of the bearing part 3142 and causing the flow rate to be too slow to form blood clots.

[0093] In order to facilitate the installation of the distribution fluid body 314 and the filter element 319, the drip chamber 31 is arranged as a split structure, including a first chamber body and a second chamber body. An outlet 312 is arranged at one end of the first chamber body away from the second chamber body, and the first chamber body and the second chamber body are connected by snap connection. The inlet 311 and the liquid replenishment port 313 are both arranged on the second chamber body. When installing the distribution fluid body 314, first insert the filter element 319 into the first chamber body and snap-connect it with the first chamber body, then insert the distribution fluid body 314 into the second chamber body, then snap-connect the first chamber body and the second chamber body, and finally apply glue at the connection between the first chamber body and the second chamber body to bond the two into one body.

[0094] The blood purification pipeline system provided in this embodiment is configured such that by disposing a shunt body 314 within the venous chamber 31 of the venous pipeline assembly 3, after the liquid supplemented through the liquid supplement inlet 313 enters the third chamber 317, it passes through the buffer portion 3141 and then enters the second chamber 316 via the communication structure. The provision of the buffer portion 3141 reduces the impact of the supplemented liquid on the blood, enabling the supplemented liquid to flow uniformly and dispersedly onto the blood and form a liquid layer, effectively isolating air and blood, and greatly reducing the risk of blood coagulation within the venous chamber 31. Additionally, by disposing a heating bladder 800 on the venous chamber inlet pipe 32 connected to the liquid inlet 311 of the venous chamber 31 within the venous pipeline assembly 3, the blood returned to the human body is heated and kept warm, enhancing the comfort of the patient.

[0095] Heating bladders 800 are disposed on both the dialysate pipeline assembly 6 and the replacement fluid pipeline assembly 7. The heating bladder 800 on the dialysate pipeline assembly 6 heats the dialysate and then enters the filter assembly, and the filter assembly realizes the function of blood purification based on the principles of diffusion, convection, and adsorption. The heating bladder 800 on the replacement fluid pipeline assembly 7 heats the replacement fluid and then enters the blood to maintain the electrolyte and acid-base balance in the blood. The mixed fluid supplement pipeline assembly 8 is connected to a fluid supplement source, and the fluid supplement source is sodium bicarbonate injection. When the replacement fluid used during the blood purification treatment is a finished replacement fluid base solution, the mixed fluid supplement pipeline assembly 8 enables the ipsilateral and proportional input of sodium bicarbonate injection and the replacement fluid base solution, meeting the treatment mode of continuous venovenous hemodiafiltration.

[0096] Further, two dialysate branch pipelines 61 are provided at one end of the dialysate pipeline assembly 6 away from the connection with the dialysate source. One of the dialysate branch pipelines 61 is connected to the filter assembly through a Hansen connector 500, and the other dialysate branch pipeline 61 supplements therapeutic medicaments in the dialysate in real time according to clinical needs. In this embodiment, the dialysate branch pipeline 61 can be used to supplement sodium bicarbonate injection, facilitating the supplementation of sodium bicarbonate injection clinically when using sodium bicarbonate injection in the replacement fluid base solution as the dialysate.

[0097] The plasma separation liquid pipeline assembly 4 includes a main plasma separation liquid pipeline 41 and a plurality of plasma separation liquid branch pipelines with different structures. One end of the main plasma separation liquid pipeline 41 is connected to the plasma separator, and the other end is connected to and / or connected to at least one plasma secondary processor with different functions through at least one of the plurality of plasma separation liquid branch pipelines with different structures. The plasma secondary processor is connected to the venous pipeline assembly 3 through a plasma separation liquid branch pipeline, or the plasma secondary processor is respectively connected to the venous pipeline assembly 3 and the waste liquid pipeline assembly 110 through two plasma separation liquid branch pipelines. In this embodiment, seven plasma separation liquid branch pipelines are provided. Through the combination of one main plasma separation liquid pipeline 41 and seven plasma separation liquid branch pipelines, a treatment mode that requires the combination of blood circulation, dialysis circulation, and albumin circulation can be completed. Among them, the seven plasma separation liquid branch pipelines are selectively used, and different plasma separation liquid branch pipelines are required in different treatment modes.

[0098] The multiple slurry dividing branch pipelines with different structures include a first slurry dividing branch pipeline 42, a second slurry dividing branch pipeline 43, a second slurry dividing branch pipeline 43, a third slurry dividing branch pipeline 44, a fourth slurry dividing branch pipeline 45, a fifth slurry dividing branch pipeline 46, a sixth slurry dividing branch pipeline 47, and a seventh slurry dividing branch pipeline 48. A clamp 100 is arranged on the first slurry dividing branch pipeline 42, and Luer connectors 200 and plugs 300 are arranged at both ends. The clamp 100 is used to control the switch of the first slurry dividing branch pipeline 42. The Luer connector 200 is used to connect with the filter assembly and is blocked by the plug 300 when the filter assembly is not connected. The first slurry dividing branch pipeline 42 is generally used for connecting perfusion devices in series. A heating bladder 800 is arranged on the second slurry dividing branch pipeline 43, and a clamp 100 is arranged at each end of the heating bladder 800. A Luer connector 200 and a plug 300 are arranged at one end of the second slurry dividing branch pipeline 43, and a small Luer connector and a small plug are arranged at the other end. A Hansen connector 500, a small Luer connector, and a small plug are arranged on the third slurry dividing branch pipeline 44. A clamp 100 is arranged on the fourth slurry dividing branch pipeline 45. A Luer connector 200 and a plug 300 are arranged at one end of the fourth slurry dividing branch pipeline 45, and a small Luer connector and a small plug are arranged at the other end. The fifth slurry dividing branch pipeline 46 includes a main branch pipeline 461, a first sub-branch pipeline 462, and a second sub-branch pipeline 463. Clamps 100 are arranged on the main branch pipeline 461, the first sub-branch pipeline 462, and the second sub-branch pipeline 463. A Luer connector 200 and a plug 300 are arranged at one end of the main branch pipeline 461, and the other end is communicated with both the first sub-branch pipeline 462 and the second sub-branch pipeline 463. A Hansen connector 500 is arranged at the end of the first sub-branch pipeline 462 far from the main branch pipeline 461, and a small Luer connector and a small plug are arranged at the end of the second sub-branch pipeline 463 far from the main branch pipeline 461. A three-way joint 600 is further arranged on the first sub-branch pipeline 462, and plugs 300 are arranged at the interfaces of the three-way joint 600 connected with other pipelines. When there is no need to connect with other pipelines, the interfaces of the three-way joint 600 connected with other pipelines are blocked by the plugs 300. A clamp 100 is arranged on the sixth slurry dividing branch pipeline 47. A Luer connector 200 and a plug 300 are arranged at one end of the sixth slurry dividing branch pipeline 47, and a small Luer connector and a small plug 300 are arranged at the other end. A three-way joint 600 is arranged on the seventh slurry dividing branch pipeline 48, and a clamp 100 is arranged at each end of the three-way joint 600. Luer connectors 200 and plugs 300 are arranged at both ends of the seventh slurry dividing branch pipeline 48.

[0099] Exemplarily, in the treatment mode of the plasma adsorption and dual plasma molecule adsorption system, the plasma separation pipeline assembly 4 includes a main plasma separation pipeline 41, a first plasma separation branch pipeline 42, and a second plasma separation branch pipeline 43. In the treatment mode of plasma adsorption, the plasma secondary processor includes a hemoperfusion cartridge. One end of the main plasma separation pipeline 41 is connected to the plasma separator, and the other end is connected to one end of the hemoperfusion cartridge. The other end of the hemoperfusion cartridge is connected to the venous pipeline assembly 3 through the second plasma separation branch pipeline 43. The heating bladder 800 on the second plasma separation branch pipeline 43 heats and keeps warm the blood returned to the human body, improving the comfort of the patient. The treatment mode of the dual plasma molecule adsorption system has one more hemoperfusion cartridge than the treatment mode of plasma adsorption, and the two hemoperfusion cartridges are connected through the first plasma separation branch pipeline 42.

[0100] In the treatment mode of double filtration plasmapheresis, the plasma separation pipeline assembly 4 includes a main plasma separation pipeline 41, a third plasma separation branch pipeline 44, and a fourth plasma separation branch pipeline 45. The plasma secondary processor further includes a filter. The inlet of the plasma separator is connected to the arterial pipeline assembly 1. One end of the main plasma separation pipeline 41 is connected to the first outlet of the plasma separator, and the other end is connected to the filter. The first outlet of the filter is connected to the third plasma separation branch pipeline 44 through a Hansen connector 500. The third plasma separation branch pipeline 44 is connected to the liquid supplement inlet 313 of the venous chamber 31 in the venous pipeline assembly 3. The second outlet of the filter is connected to the waste liquid pipeline assembly 110 through the fourth plasma separation branch pipeline 45. The second outlet of the plasma separator is connected to the liquid inlet 311 of the venous chamber 31.

[0101] In the treatment mode of the molecular adsorption recycling system and the plasma separation adsorption system, the plasma separation branch pipeline includes a main plasma separation pipeline 41, a fifth plasma separation branch pipeline 46, and two first plasma separation branch pipelines 42. The hemoperfusion cartridge includes a first hemoperfusion cartridge and a second hemoperfusion cartridge. The first inlet of the plasma separator is connected to the arterial pipeline assembly 1. One end of the main plasma separation pipeline 41 is connected to the first outlet of the plasma separator, and the other end is connected to the first hemoperfusion cartridge. The first hemoperfusion cartridge and the second hemoperfusion cartridge are connected through a first plasma separation branch pipeline 42. The second hemoperfusion cartridge is connected to the fifth plasma separation branch pipeline 46. The fifth plasma separation branch pipeline 46 is connected to the second inlet of the plasma separator through a Hansen connector 500. The second outlet of the plasma separator is connected to the first inlet of the filter through a first plasma separation branch pipeline 42. The second inlet of the filter is connected to the dialysis fluid pipeline assembly 6. The first outlet of the filter is connected to the liquid inlet 311 of the venous chamber 31 in the venous pipeline assembly 3. The liquid supplement inlet 313 of the venous chamber 31 is connected to the post-supplement branch pipeline 82 in the mixed liquid supplement pipeline assembly 8. The second outlet of the filter is connected to the waste liquid pipeline assembly 110.

[0102] Specifically, one end of the main branch pipeline 461 is connected to the second perfusion device, and the first sub-branch pipeline 462 is connected to the second inlet of the plasma separator. Before performing albumin circulation treatment, the entire blood purification pipeline system is pre-rinsed with a saline pre-rinse solution. When pre-rinsing with saline, the clamp 100 on the main branch pipeline 461 and the second sub-branch pipeline 463 is opened to pre-rinse the main branch pipeline 461, and then it enters the waste liquid pipeline assembly 110 through the second sub-branch pipeline 463. After the saline pre-rinse is completed, albumin pre-rinse is also required for the plasma separation pipeline assembly 4. When performing albumin pre-rinse, the main branch pipeline 461 and the first sub-branch pipeline 462 are interrupted through the clamp 100 on the first sub-branch pipeline 462, and it is connected to the albumin pre-rinse solution source through the three-way joint 600 on the first sub-branch pipeline 462. The albumin pre-rinse solution pre-rinses the albumin circulation pipeline composed of the plasma separator, the plasma separation pipeline assembly 4, the first perfusion device, and the second perfusion device through the first sub-branch pipeline 462.

[0103] Of course, in the molecular adsorption circulation system and the plasma separation adsorption system treatment modes, the plasma separation branch pipeline may also include a main plasma separation pipeline 41, a fifth plasma separation sub-branch pipeline 46, a first plasma separation sub-branch pipeline 42, and a seventh plasma separation sub-branch pipeline 48, that is, the seventh plasma separation sub-branch pipeline 48 replaces one first plasma separation sub-branch pipeline 42.

[0104] In the continuous plasma filtration adsorption treatment mode, the plasma separation pipeline assembly 4 includes a main plasma separation pipeline 41, a sixth plasma separation sub-branch pipeline 47, and a seventh plasma separation sub-branch pipeline 48. The first inlet of the plasma separator is connected to the arterial pipeline assembly 1. One end of the main plasma separation pipeline 41 is connected to the first outlet of the plasma separator, and the other end is connected to one end of the perfusion device. The other end of the perfusion device is connected to the sixth plasma separation sub-branch pipeline 47. The sixth plasma separation sub-branch pipeline 47 is connected to the three-way joint 600 in the middle of the seventh plasma separation sub-branch pipeline 48. The two ends of the seventh plasma separation sub-branch pipeline 48 are respectively connected to the second outlet of the plasma separator and the first inlet of the filter. The second inlet of the filter is connected to the dialysis fluid pipeline assembly 6. The first outlet of the filter is connected to the liquid inlet 311 of the venous chamber 31 of the venous pipeline assembly 3. The liquid supplement inlet 313 of the venous chamber 31 is connected to the post-supplement pipeline 82 of the mixed supplement pipeline assembly 8. The second outlet of the filter is connected to the waste liquid pipeline assembly 110.

[0105] The blood purification pipeline system provided by this embodiment further includes a priming pipeline assembly 10. The priming pipeline assembly 10 includes a priming main pipeline 101 and a plurality of priming branch pipelines 102 communicated with the priming main pipeline 101. The priming main pipeline 101 is connected to a priming liquid source. The plurality of priming branch pipelines 102 are respectively connected to the arterial pipeline assembly 1, the medicine liquid input pipeline assembly 2, the separated slurry pipeline assembly 4, and the mixed replenishing liquid pipeline assembly 8. One end of the venous pipeline assembly 3 connected to the human body is connected to the waste liquid bag 9. In this embodiment, there are two waste liquid inlet branches 91 on the waste liquid bag 9. One of the waste liquid inlet branches 91 is connected to one end of the venous pipeline assembly 3 connected to the human body, and the other waste liquid inlet branch 91 is connected to one end of the waste liquid pipeline assembly 110 away from the filter assembly.

[0106] After connecting the blood purification pipeline system to the blood purification equipment and before connecting it to the human body, it is necessary to prime each pipeline assembly. By setting a plurality of priming branch pipelines 102, only one bag of priming liquid needs to be connected to the priming main pipeline 101. The plurality of priming branch pipelines 102 are respectively connected to the arterial pipeline assembly 1, the front replenishing liquid pipeline assembly 21, and the mixed replenishing liquid pipeline assembly 8. One end of the venous pipeline assembly 3 connected to the human body is connected to the waste liquid bag 9 for priming each pipeline assembly, which simplifies the priming operation steps and greatly improves the priming efficiency of the pipeline assembly. The priming liquid source is saline. During tubing tracing, the priming main pipeline 101 is connected to the priming liquid source, and the plurality of priming branch pipelines 102 are respectively connected to the arterial pipeline assembly 1, the medicine liquid input pipeline assembly 2, the mixed replenishing liquid pipeline assembly 8, and the venous pipeline assembly 3. With such a setting, during tubing tracing, only the venous pipeline assembly 3 needs to be connected to one of the priming branch pipelines 102, which is more convenient for tubing tracing.

[0107] In this embodiment, there are four priming branch pipelines 102. When priming each pipeline assembly, one of the priming branch pipelines 102 is closed by a clamp 100, and the other three priming branch pipelines 102 are respectively connected to the arterial pipeline assembly 1, the front replenishing liquid pipeline assembly 21, and the mixed replenishing liquid pipeline assembly 8. During tubing tracing, the four priming branch pipelines 102 are respectively connected to the arterial pipeline assembly 1, the front replenishing liquid pipeline assembly 21, the mixed replenishing liquid pipeline assembly 8, and the venous pipeline assembly 3.

[0108] It should be noted that the dialysate pipeline assembly 6, the replacement fluid pipeline assembly 7, and the separated slurry pipeline assembly 4 need to be primed with additional priming liquid. The first anticoagulant medicine liquid pipeline assembly 23 and the second anticoagulant medicine liquid pipeline assembly 22 are primed separately when needed.

[0109] In this embodiment, at one end of the waste liquid pipeline assembly 110 connected to the waste liquid bag 9, there are provided two waste liquid outlet branches 1101 and one waste liquid bypass 1102. Each of the two waste liquid outlet branches 1101 can be connected to one waste liquid bag 9, or only one waste liquid outlet branch 1101 can be connected to the waste liquid bag 9, and the other waste liquid outlet branch 1101 is blocked by a plug 300. The waste liquid bypass 1102 is used to connect the waste liquid discharged from other pipelines (such as the second sub-pipeline 463 in the fifth pulp separation sub-pipeline 46).

[0110] Furthermore, in the blood purification pipeline system provided in this embodiment, pressure sensors 700 are provided in the arterial pipeline assembly 1, the pulp separation pipeline assembly 4, and the waste liquid pipeline assembly 110. In this embodiment, pressure sensors 700 are provided on the arterial main pipeline 12 connected to the human body and on the arterial main pipeline 12 connected to the arterial main pipeline 12 connected to the filter assembly. Pressure sensors 700 are provided at both ends of the pulp separation main pipeline 41 where it is connected to the plasma separator and where it is connected to the plasma secondary processor. By providing a pressure sensor 700 at the end of the pulp separation main pipeline 41 where it is connected to the plasma secondary processor, the pressure state inside the plasma secondary processor can be more intuitively monitored, increasing the safety of complex treatment modes. A pressure sensor 700 is also provided at one end of the waste liquid pipeline assembly 110 connected to the filter assembly. In this embodiment, the pressure sensors 700 are all membrane type pressure sensors. The membrane type pressure sensors adopt a closed pressure monitoring method, reducing the contact between the liquid and air inside the pipeline assembly, reducing the occurrence of coagulation phenomena, and reducing the risk of air entering the pipeline assembly and the filter assembly.

[0111] It should be noted that accessories such as clips 100, Luer connectors 200, plugs 300, or needles 400 are provided at both ends of each pipeline assembly. Users can use the clips 100 to control the opening and closing of the pipeline, connect to the filter assembly through the Luer connectors 200, block the pipeline through the plugs 300, or connect to the human body or the liquid supplement source through the needles 400, which will not be elaborated here one by one.

[0112] The above content is only a preferred embodiment of the present invention. For those of ordinary skill in the art, based on the idea of the present invention, there will be changes in the specific implementation manners and application scopes. The content of this specification should not be construed as a limitation to the present invention.

Claims

1. A blood purification pipeline system, used to connect to a blood purification device, wherein the blood purification device includes a filter assembly, characterized in that: The blood purification pipeline system comprises: An arterial line assembly (1), one end of the arterial line assembly (1) is connected to a human body, and the other end is connected to the filter assembly, and the arterial line assembly (1) is used to lead blood in a human body to the filter assembly; A venous line assembly (3), one end of which is connected to the filter assembly, and the other end of which is connected to the human body, and is used to return the blood purified by the filter assembly to the human body; A liquid medicine input pipeline assembly (2), one end of which is connected to a liquid medicine source, and the other end of which is connected to the arterial pipeline assembly (1) or the venous pipeline assembly (3); A dialysate piping assembly (6), one end of which is connected to a dialysate source, and the other end of which is connected to the filter assembly; A replacement fluid pipeline assembly (7), one end of the replacement fluid pipeline assembly (7) is connected to a replacement fluid source, and the other end is connected to the arterial pipeline assembly (1) or the venous pipeline assembly (3); A mixed fluid infusion pipeline assembly (8), one end of which is connected to a fluid infusion source, and the other end of which can be selectively connected to the arterial pipeline assembly (1) or the venous pipeline assembly (3); A plasma separation pipeline assembly (4), wherein the filter assembly comprises a plasma separator and a plasma secondary processor, one end of the plasma separator is connected to the arterial pipeline assembly (1), and the other end is connected to the plasma separation pipeline assembly (4), the plasma separation pipeline assembly (4) transports the plasma separated by the plasma separator to the plasma secondary processor, and then transports the plasma processed by the plasma secondary processor to the venous pipeline assembly (3); A waste liquid pipeline assembly (110), one end of which is connected to the filter assembly, and the other end of which is connected to the waste liquid bag (9).

2. The blood purification pipeline system according to claim 1, characterized in that: The slurry separation pipeline assembly (4) comprises a slurry separation main pipeline (41) and a plurality of slurry separation branch pipelines of different structures. One end of the slurry separation main pipeline (41) is connected to the plasma separator, and the other end is connected and / or connected to at least one of the plurality of slurry separation branch pipelines of different structures through at least one of the plasma secondary processors with different functions. The plasma secondary processor is connected to the venous pipeline assembly (3) through one of the slurry separation branch pipelines, or the plasma secondary processor is respectively connected to the venous pipeline assembly (3) and the waste liquid pipeline assembly (110) through two of the slurry separation branch pipelines.

3. The blood purification pipeline system according to claim 2, characterized in that: A plurality of pulp separation branch pipelines of different structures include a first pulp separation branch pipeline (42) and a second pulp separation branch pipeline (43); the plasma secondary processor includes a perfusion device; the plasma separator is connected to the perfusion device via the pulp separation main pipeline (41); the perfusion devices are connected to each other via the first pulp separation branch pipeline (42); and the perfusion device is connected to the venous pipeline assembly (3) via the second pulp separation branch pipeline (43).

4. The blood purification pipeline system according to claim 3, characterized in that: The plurality of pulp separation branch pipelines with different structures also include a third pulp separation branch pipeline (44) and a fourth pulp separation branch pipeline (45), and the plasma secondary processor also includes a filter. One end of the pulp separation main pipeline (41) is connected to the plasma separator, and the other end is connected to the filter. The filter is connected to the venous pipeline assembly (3) through the third pulp separation branch pipeline (44), and is connected to the waste liquid pipeline assembly (110) through the fourth pulp separation branch pipeline (45).

5. The blood purification pipeline system according to claim 4, characterized in that: The plurality of pulp separation branch pipelines with different structures also include a fifth pulp separation branch pipeline (46), the perfusion device includes a first perfusion device and a second perfusion device, one end of the pulp separation main pipeline (41) is connected to the plasma separator, and the other end is connected to the first perfusion device, the first perfusion device and the second perfusion device are connected through the first pulp separation branch pipeline (42), the second perfusion device is connected to the plasma separator through the fifth pulp separation branch pipeline (46), the plasma separator is connected to the filter through the first pulp separation branch pipeline (42), and the filter is respectively connected to the venous pipeline assembly (3), the dialysate pipeline assembly (6) and the waste liquid pipeline assembly (110).

6. The blood purification pipeline system according to claim 5, characterized in that: The fifth plasma separation branch pipeline (46) includes a main branch pipeline (461), a first sub-branch pipeline (462) and a second sub-branch pipeline (463); the main branch pipeline (461), the first sub-branch pipeline (462) and the second sub-branch pipeline (463) are all provided with clamps (100); one end of the main branch pipeline (461) is connected to the second perfusion device, and the other end is connected to the first sub-branch pipeline (462) and the second sub-branch pipeline (463); the first sub-branch pipeline (462) is connected to the plasma separator, and the second sub-branch pipeline (463) is connected to the waste liquid pipeline assembly (110).

7. The blood purification pipeline system according to claim 6, characterized in that: The first sub-branch pipeline (462) is connected to a protein pre-flushing liquid source via a three-way connector (600).

8. The blood purification pipeline system according to claim 5, characterized in that: A plurality of pulp separation branch pipelines with different structures include a sixth pulp separation branch pipeline (47) and a seventh pulp separation branch pipeline (48); one end of the pulp separation main pipeline (41) is connected to the plasma separator, and the other end is connected to one end of the perfusion device; the other end of the perfusion device is connected to the sixth pulp separation branch pipeline (47); the sixth pulp separation branch pipeline (47) is connected to the middle part of the seventh pulp separation branch pipeline (48), and the two ends of the seventh pulp separation branch pipeline (48) are respectively connected to the plasma separator and the filter.

9. The blood purification pipeline system according to any one of claims 1 to 8, characterized in that: The drug liquid input pipeline component (2) comprises a front liquid replenishment pipeline component (21), and the front liquid replenishment pipeline component (21) is connected to the arterial pipeline component (1) and is used to replenish the drug liquid.

10. The blood purification pipeline system according to claim 9, characterized in that: The drug liquid input pipeline assembly (2) also includes a first anticoagulant drug liquid pipeline assembly (23) and a second anticoagulant drug liquid pipeline assembly (22); the first anticoagulant drug liquid pipeline assembly (23) can be connected to the venous pipeline assembly (3) to replenish the first anticoagulant drug liquid; the second anticoagulant drug liquid pipeline assembly (22) can be connected to the arterial pipeline assembly (1) to replenish the second anticoagulant drug liquid; either the first anticoagulant drug liquid pipeline assembly (23) or the second anticoagulant drug liquid pipeline assembly (22) can be used selectively.

11. The blood purification pipeline system according to claim 10, characterized in that: The end of the venous pipeline assembly (3) close to the connection with the human body is provided with a first three-way one-way valve (341), and the first anticoagulant liquid pipeline assembly (23) is connected to the first three-way one-way valve (341). The first three-way one-way valve (341) is used for one-way conduction of the first anticoagulant liquid pipeline assembly (23) to the venous pipeline assembly (3).

12. The blood purification pipeline system according to claim 10, characterized in that: The blood purification pipeline system further comprises an integrated disk (5), wherein a plurality of pipeline installation positions (51) and a plurality of pipeline guide positions are arranged on the integrated disk (5), wherein the plurality of pipeline installation positions (51) are arranged at intervals along the circumference of the integrated disk (5), and the pipeline guide positions are arranged below the pipeline installation positions (51); The arterial pipeline assembly (1), the front infusion pipeline assembly (21), the replacement fluid pipeline assembly (7), the dialysate pipeline assembly (6), the slurry pipeline assembly (4), the mixed infusion pipeline assembly (8) and the waste fluid pipeline assembly (110) are fixed in sequence to the pipeline installation position (51) along the circumference of the integrated disk (5), and the first anticoagulant drug solution pipeline assembly (23) and the second anticoagulant drug solution pipeline assembly (22) are fixed to the pipeline guide position.

13. The blood purification pipeline system according to claim 12, characterized in that: The blood purification device further comprises two pipeline selectors, the integrated disk (5) is provided with two pipeline selector fixing positions (54), and the two pipeline selectors are respectively fixed on the two pipeline selector fixing positions (54); The replacement fluid pipeline assembly (7) comprises a front replacement fluid branch pipeline (71) and a rear replacement fluid branch pipeline (72), wherein the front replacement fluid branch pipeline (71) is connected to the arterial pipeline assembly (1), and the rear replacement fluid branch pipeline (72) is connected to the venous pipeline assembly (3), and one of the pipeline selectors can selectively open the front replacement fluid branch pipeline (71) or the rear replacement fluid branch pipeline (72); The mixed fluid infusion pipeline assembly (8) comprises a front fluid infusion branch pipeline (81) and a rear fluid infusion branch pipeline (82), wherein the front fluid infusion branch pipeline (81) is connected to the arterial pipeline assembly (1), and the rear fluid infusion branch pipeline (82) is connected to the venous pipeline assembly (3), and another pipeline selector can selectively open the front fluid infusion branch pipeline (81) or the rear fluid infusion branch pipeline (82).

14. The blood purification pipeline system according to any one of claims 1 to 8, characterized in that: The venous line assembly (3) comprises a venous pot (31), a fluid divider (314) is arranged in the venous pot (31), the fluid divider (314) divides the inner cavity of the venous pot (31) into a first cavity (315), a second cavity (316) and a third cavity (317), the fluid divider (314) comprises a buffer portion (3141) and a bearing portion (3142), the venous pot (31) is provided with a liquid inlet (311), a liquid outlet (312) and a liquid replenishing port (313), the liquid outlet (312) is arranged at one end of the venous pot (31), the first cavity (315) is formed between the liquid outlet (312) and the bearing portion (3142), and a liquid replenishing port (313) is formed between the bearing portion (3142) and the buffer portion (3141). The second cavity (316), the liquid inlet (311) is connected to the first cavity (315) or the second cavity (316), the third cavity (317) is formed between the buffer portion (3141) and the other end of the venous pot (31), the liquid replenishing port (313) is connected to the third cavity (317), the buffer portion (3141) is used to buffer the impact force of the liquid replenished from the liquid replenishing port (313) entering the second cavity (316), the bearing portion (3142) is connected to the inner wall of the venous pot (31), and the bearing portion (3142) and the buffer portion (3141) are both provided with a connecting structure to connect the first cavity (315), the second cavity (316) and the third cavity (317).

15. The blood purification pipeline system according to any one of claims 1 to 8, characterized in that: The dialysate pipeline assembly (6), the slurry pipeline assembly (4) and the replacement fluid pipeline assembly (7) are all provided with a heating bag (800).

16. The blood purification pipeline system according to any one of claims 1 to 8, characterized in that: The blood purification pipeline system further comprises a pre-flushing pipeline assembly (10), wherein the pre-flushing pipeline assembly (10) comprises a pre-flushing main pipeline (101) and a plurality of pre-flushing branch pipelines (102) connected to the pre-flushing main pipeline (101), wherein the pre-flushing main pipeline (101) is connected to a pre-flushing liquid source, the plurality of pre-flushing branch pipelines (102) are respectively connected to the arterial pipeline assembly (1), the liquid medicine input pipeline assembly (2) and the mixed liquid infusion pipeline assembly (8), and the venous pipeline assembly (3) is connected to the waste liquid bag (9); Alternatively, the priming main pipeline (101) is connected to a priming liquid source, and the plurality of priming branch pipelines (102) are respectively connected to the arterial pipeline assembly (1), the liquid medicine input pipeline assembly (2), the mixed fluid infusion pipeline assembly (8) and the venous pipeline assembly (3).

17. The blood purification pipeline system according to any one of claims 2 to 8, characterized in that: Pressure sensors (700) are provided at one end of the main plasma separation line (41) connected to the plasma separator and at one end of the main plasma separation line (41) connected to the plasma secondary processor.

18. The blood purification pipeline system according to any one of claims 1 to 8, characterized in that: The dialysate pipeline assembly (6) is provided with two dialysate branch pipelines (61) at one end of the dialysate pipeline assembly (6) away from the end connected to the dialysate source, wherein one of the dialysate branch pipelines (61) is connected to the filter assembly, and the other dialysate branch pipeline (61) is used to supplement the therapeutic liquid.

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