Piston driving assembly for assisting in maintaining chromatographic column

Abstract

The utility model discloses a piston driving component for assisting in maintaining a chromatographic column. The piston driving component comprises a driving part, a trapezoidal screw rod and a piston, the driving part comprises a first speed reducer, a motor and a plurality of second speed reducers which are arranged on the speed reducer base; the first speed reducer is arranged in the middle of the speed reducer base, the first end of the first speed reducer is connected with the motor, the second end is directly connected with a second speed reducer or a steering gear, and the third end is connected with at least one steering gear. Each steering gear is connected with N-1 second speed reducers, N is larger than or equal to 2 and smaller than or equal to 4, and the second speed reducers are in one-to-one correspondence with the trapezoidal screws and are in detachable driving connection with the trapezoidal screws. According to the scheme, the motor is adopted to drive the multiple speed reducers to synchronously rotate so that the piston can stably ascend and descend, hundreds of times of torsion output can be formed by the multiple speed reducers, the power of the motor is greatly reduced, the chromatographic column barrel can be driven to ascend and descend by installing the piston on the upper portion of the chromatographic column structure, and in-situ maintenance operation can be conveniently conducted on components such as a sieve plate of the chromatographic column.

Description

Technical Field

[0001] The utility model relates to a structural device for on-site maintenance of a chromatography column, in particular to a piston drive assembly for assisting in maintaining a chromatography column, belonging to the technical field of biopharmaceuticals. Background Art

[0002] A chromatography column is the main body in chromatography technology. It is a chromatography method for separating according to the different distribution coefficients of each component in a sample mixture between a stationary phase and a mobile phase. Chromatography technology can separate heat-sensitive or easily inactivated products, such as proteins, polysaccharides, and polypeptides, under relatively mild conditions. Therefore, a chromatography column is the key to achieving chromatographic separation. Moreover, the internal components of the chromatography column (such as valves, seals, sieves, distributors, etc.) need to be maintained or cleaned regularly.

[0003] However, in the existing structure of a chromatography column, the piston is driven by a central reduction motor. During the process of guiding the piston to lift and lower via three guide rods, slight deviation still occurs, thus affecting the maintenance column efficiency of the chromatography column in the column barrel assembly. Therefore, it is necessary to propose a piston drive assembly for assisting in maintaining a chromatography column to assist in improving the maintenance efficiency of the chromatography column. Summary of the Invention

[0004] The purpose of the utility model is to solve the above problems and provide a piston drive assembly for assisting in maintaining a chromatography column.

[0005] The technical solution of the utility model is: a piston drive assembly for assisting in maintaining a chromatography column, characterized in that: it includes a driving part, and the driving part includes a first reduction gear, a motor, and several second reduction gears arranged on the reduction gear base. The first reduction gear is arranged at the middle position of the reduction gear base, and the first end of the first reduction gear is connected to the motor. The second end of the first reduction gear is directly connected to a second reduction gear or a steering gear, and the third end of the first reduction gear is also connected to at least one steering gear. The output end of the steering gear is connected to N - 1 second reduction gears, where 2 ≤ N ≤ 4. The second reduction gears correspond to the trapezoidal screws one by one, and each second reduction gear is detachably connected to the trapezoidal screw (for example: flange connection or bolt connection).

[0006] Further, in the above piston drive assembly for assisting in maintaining a chromatography column, it further includes a piston, and the piston is arranged vertically below the driving part.

[0007] Further, in the above piston drive assembly for assisting in maintaining a chromatography column, the piston is connected to the driving part through each trapezoidal screw.

[0008] Furthermore, in the above piston drive assembly for assisting in maintaining a chromatography column, the first reduction gear is a bevel gear reduction gear.

[0009] Furthermore, for the piston drive assembly of the above-mentioned auxiliary maintenance chromatography column, where: the second reducer is a worm and worm gear reducer.

[0010] Furthermore, for the piston drive assembly of the above-mentioned auxiliary maintenance chromatography column, where: the first end of the first reducer is connected to the motor through a coupling, and a reducer flange is positioned on the first reducer by screws outside the coupling.

[0011] Furthermore, for the piston drive assembly of the above-mentioned auxiliary maintenance chromatography column, where: the third end of the first reducer is connected to the steering gear through the coupling, and an extended flange is positioned on the steering gear by screws outside the coupling.

[0012] Compared with the prior art, after adopting the technical solution of the present utility model, a motor is used to drive multiple reducers to rotate synchronously to make the piston lift smoothly. The multi-stage reducer can form a torque output of a hundred times, greatly reducing the power of the motor. Then, the piston structure is installed on the upper part of the chromatography column structure to drive the lifting of the chromatography column barrel, so as to disassemble and assemble the chromatography column, thereby enabling in-situ maintenance operations on components such as the sieve plate of the chromatography column. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a schematic structural diagram of the drive module (three groups of second reducers are used) and the piston of the present utility model;

[0014] Figure 2 It is a schematic structural diagram of the drive module (three groups of second reducers are used) of the present utility model;

[0015] Figure 3 It is a schematic structural diagram of the drive module (four groups of second reducers are used) of the present utility model;

[0016] Figure 4 It is a top view of the drive module (four groups of second reducers are used) of the present utility model.

[0017] The meanings of the reference numerals in the drawings are as follows: 1 - reducer base, 2 - first reducer, 3 - motor, 4 - coupling, 5 - reducer flange, 6 - extended flange, 7 - steering gear, 8 - second reducer, 9 - trapezoidal screw, 10 - piston. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0018] The technical solution of the present utility model will be further elaborated below in conjunction with the drawings to make it easier to understand and master. Components such as the coupling 4, reducer flange 5, extended flange 6, and steering gear 7 involved are all commonly known and used by those of ordinary skill in the art, and there are no special requirements for them in this case.

[0019] AsFigures 1 to 2 As shown in the figure, a piston drive assembly for assisting in maintaining a chromatography column of the present utility model includes a driving part. The driving part includes a first speed reducer 2, a motor 3 and several second speed reducers 8 arranged on a speed reducer base 1. The first speed reducer 2 is arranged at the middle position of the speed reducer base 1, and the first end of the first speed reducer 2 is connected to the motor 3. The second end of the first speed reducer 2 is directly connected to a second speed reducer 8; the third end of the first speed reducer 2 is also connected to a steering gear 7, and two second speed reducers 8 are connected to the output end of the steering gear 7. The second speed reducers 8 correspond to the trapezoidal screws 9 one by one, and each second speed reducer 8 is connected to the trapezoidal screw 9 in a detachable manner (for example: flange connection, bolt connection). The driving part is arranged vertically above a piston 10.

[0020] As Figures 3 to 4 As shown in the figure, a piston drive assembly for assisting in maintaining a chromatography column of the present utility model includes a driving part. The driving part includes a first speed reducer 2, a motor 3 and several second speed reducers 8 arranged on a speed reducer base 1. The first speed reducer 2 has one input end and two output ends. The first speed reducer 2 is arranged at the middle position of the speed reducer base 1, and the input end of the first speed reducer 2 is connected to the motor 3. One output end of the first speed reducer 2 is directly connected to a steering gear 7, and two second speed reducers 8 are connected to the steering gear 7; the other output end of the first speed reducer 2 is also connected to a steering gear 7, and two second speed reducers 8 are connected to the steering gear 7. The number of the second speed reducers 8 corresponds to the number of the trapezoidal screws 9 arranged, and each second speed reducer 8 is connected to the trapezoidal screw 9 in a detachable manner.

[0021] Further, the piston 10 is connected to the driving part through each trapezoidal screw 9, and the second speed reducer can realize synchronous rotation, thereby driving three or four trapezoidal screws to rise and fall synchronously, and finally stably driving the piston 10 to lift and lower, avoiding guiding deviation.

[0022] Preferably, in the above structure: the first speed reducer 2 is a bevel gear speed reducer, and the bevel gear speed reducer can adopt bevel gear speed reducers of models HD series and HDAF series. Inside the bevel gear speed reducer is a pair of bevel gears and two pairs of helical gears, achieving the effects of steering, speed reduction and torque increase. Its characteristics are high rigidity, low inertia and large transmission torque, capable of quickly responding to and tracking commands, improving the transmission dynamic performance balance and stability of the entire driving part.

[0023] Preferably, in the above structure: the second speed reducer 8 is a worm and worm gear speed reducer, and the worm and worm gear speed reducer can adopt the RV type or S series worm and worm gear speed reducers. The worm and worm gear speed reducer uses a gear speed converter to reduce the rotation speed of the motor 3 to the required rotation speed and obtain a larger torque to increase the torque.

[0024] Specifically, the first end of the first speed reducer 2 is connected to the motor 3 through a coupling 4, and a speed reducer flange 5 is positioned on the first speed reducer by screws outside the coupling 4. The sealing performance is improved through the speed reducer flange 5, which is convenient for daily maintenance.

[0025] Specifically, the third end of the first speed reducer 2 is connected to the steering gear 7 through the coupling 4, and an extended flange 6 is positioned on the steering gear 7 by screws outside the coupling 4. The installation process is simplified through the extended flange 6, and the stability and reliability are improved.

[0026] According to the technical solution of the present invention, when the body centers of the second speed reducers 8 are used as the base points, the base points form a common circle on the same plane, and the center of the common circle is coaxially arranged with the vertical center line of the piston 10, so that the center of gravity of the piston 10 always remains at the central position of the piston 10 when the piston 10 moves up and down.

[0027] In the technical solution of the present invention, the driving structure of the first speed reducer 2 and several second speed reducers 8 is set, and the key technology of this case is that the driving structure synchronously drives the trapezoidal screw rod 9 to lift and lower the piston 10. Figures 1 to 3 Among them, the relevant components involved in the driving part with three groups of second speed reducers and the driving part with four groups of second speed reducers are respectively highlighted. For components such as the coupling 4, the speed reducer flange 5, the extended flange 6, and the steering gear 7, those of ordinary skill in the art can make conventional settings according to the existing technology, and there are no special requirements for the model selection and combined use of them in this case.

[0028] Thus, adopting the technical solution of the present utility model, first, the chromatography column structure is installed at the lower part of the piston 10. The first reduction gear 2 includes one input end and two output ends. Start the motor 3. After decelerating and increasing torque by driving the input end of the first reduction gear 2 (i.e., the first reduction gear 2 adopts a bevel gear (or tapered gear) reduction motor), one output end directly drives a second reduction gear (i.e., the second reduction gear adopts a worm and worm gear reduction motor), and the other output end drives two second reduction gears through a steering gear (i.e., the second reduction gear adopts a worm and worm gear reduction motor). The synchronous action between the reduction gears realizes the torque and speed values required by the piston 10. A trapezoidal screw sleeve matching the trapezoidal screw 9 is connected to the turbine through screws. Each trapezoidal screw sleeve rotates together with the turbine to transmit power smoothly. The trapezoidal screw 9 is sleeved in the middle of the trapezoidal screw sleeve. When the trapezoidal screw sleeve rotates forward and backward, it correspondingly drives the trapezoidal screw 9 to perform lifting operations. The screw is connected to the piston 10, thereby driving the lifting of the piston 10. Finally, the column barrel structure of the chromatography column is operated by the lifting of the piston 10, so as to disassemble and assemble the chromatography column in place and maintain its internal components, such as valves, seals, screens, distributors, etc.

[0029] It can be found from the above description that, compared with the prior art, after adopting the technical solution of the present utility model, the motor is used to drive multiple reduction gears to rotate synchronously to make the piston lift smoothly. The multi-stage reduction gears can form a torque output of a hundred times, greatly reducing the power of the motor. By being installed at the upper part of the chromatography column structure, it can drive the column barrel of the chromatography column to lift, so as to disassemble and assemble the chromatography column. Therefore, it is suitable for the maintenance and use of large chromatography column structures.

[0030] The technical solution, working process and implementation effect of the present utility model have been described in detail above. It should be noted that the described are only typical examples of the present utility model. In addition, the present utility model can also have many other specific implementation manners. Any technical solutions formed by equivalent replacement or equivalent transformation fall within the scope of protection required by the present utility model.

Claims

1. A piston drive assembly for assisting in the maintenance of a chromatography column, comprising a drive unit, a plurality of trapezoidal screws (9), and a piston (10), characterized in that: The driving unit comprises a first reducer (2), a motor (3) and a plurality of second reducers (8) arranged on a reducer base (1); The first reducer (2) is arranged at a middle position of the reducer base (1), and a first end of the first reducer (2) is connected to the motor (3); The second end of the first reducer (2) is directly connected to a second reducer (8) or a steering gear (7); The third end of the first reducer (2) is also connected to at least one steering gear (7); The steering gear (7) is connected to N-1 second reducers (8), 2≤N≤4; The second reducers (8) correspond to the trapezoidal screws (9) one by one, and each second reducer (8) is detachably connected to the trapezoidal screw (9).

2. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 1, characterized in that: It also comprises a piston (10), wherein the piston (10) is arranged at the lower part of the driving part in a vertical direction.

3. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 2, characterized in that: The piston (10) and the driving part are connected via trapezoidal screws (9).

4. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 1, characterized in that: The first reducer (2) is a bevel gear reducer.

5. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 1, characterized in that: The second reducer (8) is a worm gear reducer.

6. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 1, characterized in that: The first end of the first reducer (2) is connected to the motor (3) via a coupling (4), and a reducer flange (5) is positioned on the first reducer via screws on the outside of the coupling (4).

7. The piston drive assembly for assisting in the maintenance of a chromatography column according to claim 6, characterized in that: The third end of the first reducer (2) is connected to the steering gear (7) via the coupling (4), and an extended flange (6) is positioned on the steering gear (7) via screws on the outside of the coupling (4).

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