Preparation system of levetiracetam injection

Abstract

The utility model discloses a preparation system of a levetiracetam injection. A mixing device comprises a first mixing unit and a second mixing unit which are communicated with each other, the first mixing unit comprises a shell, and a liquid flowing plate is arranged in the shell and used for receiving liquid flowing out of the main liquid pipe and the auxiliary material tank and enabling the liquid to be mixed in a flowing and dripping manner; the second mixing unit comprises a cylinder body, and the interior of the cylinder body is divided into a plurality of separated cavity spaces by the partition plates. The utility model relates to the technical field of pharmaceutical equipment, and the system not only improves the mixing efficiency and shortens the preparation time, but also ensures the uniformity and stability of liquid medicine, and provides a powerful guarantee for producing high-quality medicaments. And multi-stage and multi-mode mixing in the online liquid conveying process is also realized. The multi-stage mixing strategy ensures that each step from preliminary mixing to final uniform mixing can be effectively controlled, so that the mixing efficiency and the liquid medicine quality are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical equipment, and specifically relates to a preparation system for levetiracetam injection. Background Art

[0002] In the existing pharmaceutical preparation system, the preparation process of levetiracetam injection usually involves putting water for injection, levetiracetam, sodium chloride, sodium acetate trihydrate and a pH regulator into a stirring tank together, and then stirring through stirring blades to achieve mixing. This method has some obvious limitations and deficiencies. First of all, the whole mixing process takes a long time because it is necessary to wait for all components to be fully dissolved and evenly mixed. Secondly, since the liquid mainly rotates in one direction in the stirring tank, the mixing effect is not ideal, and the situation of uneven distribution of components may occur. In addition, the traditional stirring method is difficult to achieve high-efficiency online mixing, that is, continuous mixing during the conveying process, which is not conducive to improving production efficiency and ensuring the quality of pharmaceuticals. Therefore, there is an urgent need in the prior art for a preparation system that can mix liquid medicine efficiently, quickly and evenly. Summary of the Utility Model

[0003] Aiming at the deficiencies of the prior art, the utility model provides a preparation system for levetiracetam injection, which solves the problems of long time consumption and poor mixing effect of the existing liquid medicine mixing device.

[0004] To achieve the above purpose, the utility model is realized through the following technical solutions: A preparation system for levetiracetam injection includes a mixing device, an adsorption unit and a filtering unit that are sequentially connected through a connecting pipeline. The mixing device includes a first mixing unit and a second mixing unit that are connected to each other; a main liquid pipe and an auxiliary material tank are connected to the first mixing unit.

[0005] The first mixing unit includes a housing, and a liquid flow plate is arranged in the housing to receive the liquids flowing out of the main liquid pipe and the auxiliary material tank and make the liquids be mixed in a flowing and dripping state.

[0006] The second mixing unit includes a cylinder body, and a plurality of mutually staggered partition plates are arranged in the cylinder body, and the liquid flows on each partition plate in turn; the partition plates divide the inside of the cylinder body into a plurality of partition chamber spaces, and a stirring device is arranged in each partition chamber space.

[0007] Preferably, the stirring device includes a main shaft provided with stirring blades, and a motor is arranged on the main shaft to drive the main shaft to rotate forward and backward at different speeds.

[0008] The main shaft sequentially penetrates through each partition plate, and stirring blades are arranged on the part of the main shaft in each partition chamber space.

[0009] Preferably, a liquid level detection unit is arranged in the partition cavity space. The liquid level detection unit includes a first liquid level sensor and a second liquid level sensor. The first liquid level sensor is arranged above the partition cavity space, and the second liquid level sensor is arranged below the first liquid level sensor.

[0010] Preferably, the partition plate includes a free end and a fixed end. The fixed end is fixed on the cylinder body, and a liquid flow part for the liquid to flow downward is formed between the free end and the cylinder body.

[0011] The liquid flow parts on each partition plate are arranged alternately left and right with the main axis as the center line.

[0012] Preferably, the liquid flow part is a through hole or a hollow pipe, and a valve is arranged.

[0013] Preferably, the liquid flow plate includes a first even flow plate. The first even flow plate divides the inner cavity of the shell into a liquid mixing cavity and a liquid flow cavity. At least one end of the first even flow plate is a liquid flow end, so that the liquid in the liquid mixing cavity flows to the liquid flow cavity. A second punching plate is arranged on the first flat plate, and the liquid flows downward through the second punching plate and the liquid flow end when flowing on the first flat plate.

[0014] Preferably, the even flow plate further includes a second even flow plate arranged below the first even flow plate. A clamping cavity is formed between the second even flow plate and the first even flow plate. A third punching plate is arranged on the second even flow plate to receive the liquid flowing out of the first even flow plate, change the flow direction of the liquid and then flow into or drip into the liquid flow cavity.

[0015] Preferably, a flow guide cover is arranged between the liquid flow end of the first even flow plate and the liquid inlet end of the second even flow plate. The flow guide cover is arc-shaped in the projection of the front view. The flow guide cover has a first opening part and a second opening part. The first opening part is connected to the liquid flow end of the first even flow plate, and the second opening part is connected to the liquid inlet end of the second even flow plate; the opening height of the first opening part is greater than the opening height of the second opening part.

[0016] Preferably, a plurality of compound liquid pipelines are connected to the auxiliary material tank, and the compound liquid pipelines are connected to the auxiliary material tank vertically or obliquely.

[0017] Preferably, the bottom of the auxiliary material tank is connected to a spray box through a pipeline. The spray box is fixed on the shell, and a first punching plate is arranged on the bottom surface of the spray box.

[0018] The beneficial effects of the present utility model: By using a preparation system for levetiracetam injection provided by the present utility model, compared with the prior art, through the innovative design of introducing the first mixing unit and the second mixing unit, the on-line mixing of the liquid medicine in a flowing manner is realized, thereby overcoming many deficiencies of the traditional method and bringing significant beneficial effects.

[0019] First, the design of the first mixing unit enables the liquid medicine to exhibit two states, dripping and flowing, during the configuration process and undergo repeated mixing. This design not only speeds up the mixing process but also promotes the full contact and interaction between components by changing the flow state of the liquid medicine, thereby achieving a more uniform and thorough mixing effect.

[0020] Secondly, the introduction of the second mixing unit further optimizes the mixing process. This unit can pause the liquid medicine in a certain partition cavity space for stirring when it is flowing. Such a design allows the liquid medicine to be fully stirred in each partition cavity space, ensuring the uniformity of mixing. At the same time, the repeated flow of the liquid medicine in each partition cavity space also realizes on-line stirring, which means that during the entire transportation process, the liquid medicine can be continuously and uniformly mixed.

[0021] In summary, this system not only improves the mixing efficiency, shortens the configuration time, but also ensures the uniformity and stability of the liquid medicine, providing a strong guarantee for the production of high-quality pharmaceuticals. It also realizes multi-stage and multi-mode mixing during the on-line liquid transportation process. This multi-stage mixing strategy ensures that every step from the preliminary mixing to the final uniform mixing can be effectively controlled, thereby improving the mixing efficiency and the quality of the liquid medicine. Description of the Drawings

[0022] Figure 1 is a schematic three-dimensional structure diagram of the present utility model;

[0023] Figure 2 is of the present utility model Figure 1 front view;

[0024] Figure 3 is a schematic structure diagram of the first mixing unit of the present utility model;

[0025] Figure 4 is a schematic structure diagram of the partition board of the present utility model.

[0026] Description of the Reference Numerals in the Drawings

[0027] 1, auxiliary material tank; 2, main liquid pipe; 3, first mixing unit; 4, spraying box; 5, second mixing unit; 6, adsorption unit; 7, filtering unit; 8, first flat plate; 9, mixing liquid cavity; 10, liquid flowing cavity; 11, guiding cover; 12, second flat plate; 13, compound liquid pipeline; 14, main shaft; 15, partition cavity space; 16, partition board; 17, stirring blade; 18, first liquid level sensor; 19, second liquid level sensor; 20, connecting pipeline; 21, first punching plate; 22, second punching plate; 23, third punching plate; 24, clamping cavity; 25, liquid flowing part; 26, valve. Detailed Embodiments

[0028] Next, in combination with the accompanying drawings in the embodiments of the present utility model, the technical solutions in the embodiments of the present utility model will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. As long as the effects of the present utility model can be exerted, various changes can be made to the implementation solutions.

[0029] Through those skilled in the art, the components in this case are connected in sequence. For the specific connection and operation sequence, reference should be made to the following working principle. The detailed connection means are well-known techniques in the art. The following mainly introduces the working principle and process.

[0030] Refer to Figures 1-4 A preparation system for a levetiracetam injection of this implementation solution will be described.

[0031] The existing preparation system includes a mixing device, an adsorption unit 6, and a filtration unit 7 that are sequentially connected through a connecting pipe 20.

[0032] As Figure 1 shown, in this embodiment, the mixing device includes a first mixing unit 3 and a second mixing unit 5 that are connected to each other; a main liquid pipe 2 and an auxiliary material tank 1 are connected to the first mixing unit 3. The main liquid pipe 2 is for injection water, and the auxiliary material pipe 1 contains added and configured levetiracetam, sodium chloride, sodium acetate trihydrate, and a pH regulator. The injection water and levetiracetam, sodium chloride, sodium acetate trihydrate, and pH regulator flow into the first mixing unit 3 through the main liquid pipe 2 and the auxiliary material tank 1 for the first-step mixing, and then flow into the second mixing unit 5 for the second-step mixing.

[0033] As Figure 1 and Figure 2 shown, a plurality of compound liquid pipes 13 are connected to the auxiliary material tank 1, and the compound liquid pipes 13 are connected to the auxiliary material tank 1 vertically or obliquely. The bottom of the auxiliary material tank 1 is connected to a spray box 4 through a pipe. The spray box 4 is fixed on the housing, and a first punching plate 21 is provided on the bottom surface of the spray box 4. In one embodiment, a booster pump is provided on the pipe to pressurize and transport the mixed liquid in the auxiliary material tank 1 into the spray box 4, and then uniformly input it into the first mixing unit 3 in a droplet or water column shape through the first punching plate 21 to contact and mix with the injection water to form a mixed liquid.

[0034] As Figure 2 shown, the first mixing unit 3 includes a housing, and a liquid flow plate is arranged in the housing. The liquid flow plate receives the liquids flowing out of the main liquid pipe 2 and the auxiliary material tank 1 and makes the liquids mix in a flowing and dripping state.

[0035] Specifically, the liquid flow plate includes a first horizontal flow plate 8, which divides the inner cavity of the housing into a liquid mixing cavity 9 and a liquid flow cavity 10. The first step of mixing is completed during the process of the mixed liquid flowing from the liquid mixing cavity 9 into the liquid flow cavity 10. At least one end of the first horizontal flow plate 8 is a liquid flow end, enabling the liquid in the liquid mixing cavity 9 to flow towards the liquid flow cavity 10. A second punching plate 22 is provided on the first flat plate 8, and the liquid flows downward through the second punching plate 22 and the liquid flow end when flowing on the first flat plate 8. When the mixed liquid is evenly distributed on the first horizontal flow plate 8, it flows towards the liquid flow end, and part of the liquid drips downward in the form of droplets or water columns through the second punching plate 22; part of the liquid flows downward through the liquid flow end of the first horizontal flow plate 8 and contacts the mixed liquid dripping through the second punching plate 22, and the mixed liquid flowing out in two directions collides and blends after contact for re-mixing.

[0036] Further, the horizontal flow plate further includes a second horizontal flow plate 12 disposed below the first horizontal flow plate 8. A clamping cavity 24 is formed between the second horizontal flow plate 12 and the first horizontal flow plate 8. A third punching plate 23 is provided on the second horizontal flow plate 12 to receive the liquid flowing out of the first horizontal flow plate 8, change the flow direction of the liquid, and then flow into or drip into the liquid flow cavity 10.

[0037] A flow guide cover 11 is provided between the liquid flow end of the first horizontal flow plate 8 and the liquid inlet end of the second horizontal flow plate 12. The flow guide cover 11 is arc-shaped in the front view projection. The flow guide cover 11 has a first opening and a second opening. The first opening is connected to the liquid flow end of the first horizontal flow plate 8, and the second opening is connected to the liquid inlet end of the second horizontal flow plate 12; the opening height of the first opening is greater than the opening height of the second opening. By adopting the design of different opening heights, the outflow speed of the liquid at the second opening is increased, and the thickness of the outflowing liquid is thinned, so that the dripping liquid can better collide and contact with the scouring outflowing liquid for mixing.

[0038] During actual use, the liquid on the first horizontal flow plate 8 flows into the clamping cavity 24 in two directions. Part of the liquid changes direction and flows downward through the flow guide cover 11, and when flowing out through the second opening of the flow guide cover 11, it scours on the second horizontal flow plate 12. At this time, the other part of the liquid dripping downward in the form of droplets or water columns through the second punching plate 22 drips on the scouring liquid, and after forming a flowing state of contact, they collide and contact for mixing. Finally, the mixed liquid flowing into the liquid flow cavity 10 flows into the second mixing unit 5.

[0039] As Figure 2 shown, the second mixing unit 5 includes a cylinder body, and a plurality of mutually staggered partition plates 16 are arranged in the cylinder body. The liquid flows on each partition plate 16 in turn; the partition plates 16 divide the inside of the cylinder body into a plurality of partition cavity spaces 15, and a stirring device is arranged in each partition cavity space 15. The stirring device works to stir and remix the mixed liquid flowing in the partition cavity space 15 to enhance the mixing and stirring effect.

[0040] The stirring device includes a main shaft 14 provided with stirring blades 17. The main shaft 14 is provided with a motor, which is a servo motor or a reduction motor, and can drive the main shaft 14 to rotate forward and backward at different speeds; the main shaft 14 sequentially penetrates each partition 16 and is rotatably connected to each partition 16. Stirring blades 17 are provided on the part of the main shaft 14 in each partition space 15, and the mixed liquid can be stirred by the stirring blades 17 when flowing through each partition space 15 in turn. Moreover, different types of stirring blades 17 can be provided in each partition space 15, for example, one or several of bevel-cut blades, helical blades or paddle blades can be selected.

[0041] A liquid level detection unit is provided in the partition space 15. The liquid level detection unit includes a first liquid level sensor 18 and a second liquid level sensor 19. The first liquid level sensor 18 is arranged above the partition space 15, and the second liquid level sensor 19 is arranged below the first liquid level sensor 18.

[0042] The partition 16 includes a free end and a fixed end. The fixed end is fixed on the cylinder body, and a liquid flowing part 25 for the liquid to flow downward is formed between the free end and the cylinder body; the liquid flowing parts 25 on each partition 16 are arranged alternately left and right with the main shaft 14 as the center line. The liquid flowing part 25 is a through hole or a hollow tube, and a valve 26 is provided.

[0043] In one implementation, by the cooperation of the liquid level detection unit and the valve 26, it can be realized that when the mixed liquid in a certain partition space 15 reaches the set height of the first liquid level sensor 18, it automatically discharges downward, and the valve 26 automatically closes when it is lower than the second liquid level sensor 19. In another implementation, the valve 26 is set to the normally open state, and the liquid level detection element is closed, so that the mixed liquid continuously flows downward and is stirred by the stirring blades 17 during the repeatedly changing flow process, realizing multi-stage and multiple-mode mixing during the on-line liquid transportation process.

[0044] Working principle: The purified water for injection flows into the first mixing unit 3 through the main liquid pipe 2 and flows on the first flat plate 8. The proportioning liquid in the auxiliary material tank 1 drips onto the first flat plate 8 in the form of drops or water columns through the first punching plate 21 and contacts and mixes with the purified water for injection to form a mixed liquid. The liquid on the first flat plate 8 flows into the clamping cavity 24 in two directions. Part of the liquid changes direction and flows downward through the flow guiding cover 11, and when flowing out through the second opening of the flow guiding cover 11, it flushes on the second flat plate 12. At this time, another part of the liquid dripping downward in the form of drops or water columns through the second punching plate 22 drips onto the flushing liquid, forming a contact after flowing state and then impacting and contacting for mixing. Finally, the mixed liquid flowing into the liquid flowing cavity 10 flows into the cylinder body.

[0045] The mixed liquid after the first - step mixing flows sequentially within each partition cavity space 15. When flowing within each partition cavity space 15, the flow direction changes, and the liquid within each partition cavity space 15 is stirred by the stirring blades 17.

[0046] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A preparation system for levetiracetam injection, comprising a mixing device, an adsorption unit (6) and a filtration unit (7) which are sequentially connected via a connecting pipe (20), characterized in that: The mixing device comprises a first mixing unit (3) and a second mixing unit (5) which are connected to each other; the first mixing unit (3) is connected to a main liquid pipe (2) and an auxiliary material tank (1); The first mixing unit (3) comprises a shell, wherein a liquid flow plate is arranged in the shell, receiving the liquid flowing out of the main liquid pipe (2) and the auxiliary material tank (1) and mixing the liquid in a flowing and dripping state; The second mixing unit (5) comprises a cylinder, wherein a plurality of interlaced partitions (16) are arranged in the cylinder, and the liquid flows on each of the partitions (16) in sequence; the partitions (16) divide the cylinder into a plurality of compartment spaces (15), and each of the compartment spaces (15) is provided with a stirring device.

2. A preparation system for levetiracetam injection according to claim 1, characterized in that: The stirring device comprises a main shaft (14) provided with a stirring blade (17), and the main shaft (14) is provided with a motor to drive the main shaft (14) to rotate forward and reverse at different speeds; The main shaft (14) passes through each partition (16) in sequence, and a stirring blade (17) is provided on the part of the main shaft (14) in each compartment space (15).

3. A preparation system for levetiracetam injection according to claim 1 or 2, characterized in that: A liquid level detection unit is arranged in the compartment space (15), and the liquid level detection unit comprises a first liquid level sensor (18) and a second liquid level sensor (19), wherein the first liquid level sensor (18) is arranged above the compartment space (15), and the second liquid level sensor (19) is arranged below the first liquid level sensor (18).

4. A preparation system for levetiracetam injection according to claim 1 or 2, characterized in that: The partition (16) comprises a free end and a fixed end, the fixed end is fixed on the cylinder, and a liquid flow portion (25) is formed between the free end and the cylinder for allowing liquid to flow out downwards; The liquid flow parts (25) on each of the partitions (16) are arranged alternately on the left and right sides with the main axis (14) as the center line.

5. A preparation system for levetiracetam injection according to claim 4, characterized in that: The liquid flow portion (25) is a through hole or a hollow tube and is provided with a valve (26).

6. A preparation system for levetiracetam injection according to claim 1, characterized in that: The liquid flow plate comprises a first flat plate (8), the first flat plate (8) divides the inner cavity of the shell into a liquid mixing cavity (9) and a liquid flow cavity (10), at least one end of the first flat plate (8) is a liquid flow end, so that the liquid in the liquid mixing cavity (9) flows toward the liquid flow cavity (10), and a second perforated plate (22) is arranged on the first flat plate (8), and when the liquid flows on the first flat plate (8), it flows downward through the second perforated plate (22) and the liquid flow end.

7. A preparation system for levetiracetam injection according to claim 6, characterized in that: The advection plate further comprises a second advection plate (12) arranged below the first advection plate (8), a clamping cavity (24) being formed between the second advection plate (12) and the first advection plate (8), and a third perforated plate (23) being arranged on the second advection plate (12) for receiving liquid flowing out of the first advection plate (8) and redirecting the liquid flow so that the liquid flows into or drips into the liquid flow cavity (10).

8. A preparation system for levetiracetam injection according to claim 6, characterized in that: A flow guide cover (11) is arranged between the liquid flow end of the first flat plate (8) and the liquid inlet end of the second flat plate (12); the flow guide cover (11) is arc-shaped in front view projection; the flow guide cover (11) has a first opening and a second opening; the first opening is connected to the liquid flow end of the first flat plate (8), and the second opening is connected to the liquid inlet end of the second flat plate (12); the opening height of the first opening is greater than the opening height of the second opening.

9. A preparation system for levetiracetam injection according to claim 1, characterized in that: The auxiliary material tank (1) is connected to a plurality of compound liquid pipelines (13), and the compound liquid pipelines (13) are connected to the auxiliary material tank (1) in a vertical or inclined manner.

10. A preparation system for levetiracetam injection according to claim 1, characterized in that: The bottom of the auxiliary material tank (1) is connected to a spray box (4) via a pipeline; the spray box (4) is fixed on the shell; and a first perforated plate (21) is provided on the bottom surface of the spray box (4).

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