Reactor for synthesizing and preparing L-menthol glyoxylate

Abstract

The utility model relates to the technical field of preparation of L-menthol glyoxylate, and discloses a reactor for synthesizing and preparing L-menthol glyoxylate, which comprises an outer shell and a connecting cover plate, and a pump body is mounted at the top of the outer shell; stirring rods are mounted on the periphery of the surface of the column body, the column body is communicated and connected with a spraying head, the column body is communicated with the pump body, and side scraping plates are connected to the periphery of the column body; and the bottom of the rotating base is coaxially connected with a driving motor. According to the reactor for synthesizing and preparing L-menthol glyoxylate, after raw materials are discharged after reaction in the outer shell, a driving motor drives a column body, a stirring rod and a side scraper to rotate through a rotating base, the side scraper scrapes residues on the inner wall of the outer shell, a pump body is communicated with an external cleaning water or chemical reagent position, and the raw materials are discharged out of the outer shell. The liquid is conveyed into the column body, the liquid is jetted to the inner wall of the outer shell through the jet head, and then residues are scraped off. And comprehensive scraping can be carried out.

Description

Technical Field

[0001] The utility model relates to the technical field of preparation of L-menthol glyoxylate, in particular to a reactor for the synthesis and preparation of L-menthol glyoxylate. Background Art

[0002] L-Menthol glyoxylate is an important chemical substance. Appearance: white to off-white crystals. Melting point: 76-79℃, boiling point: 95-96℃ / 0.3mm, density: 1.182g / cm 3 , refractive index: 1.458. It is mainly used as a pharmaceutical intermediate, especially as a synthetic intermediate for antiviral drugs such as lamivudine and emtracheibine. The synthesis of L-menthol glyoxylate is a chemical reaction process involving multiple steps, including heating, reflux, dehydration, separation and purification, and hydrolysis and crystallization. In the process of L-menthol glyoxylate synthesis, reactors are required for heating, reflux, dehydration, separation, purification and other steps.

[0003] The common reactor for the synthesis and preparation of L-menthol glyoxylate is usually composed of a reactor body, a coil, a stirrer, a motor, a feed port, a discharge port, a pressure regulating valve, etc. First, the raw materials are put into the reactor body through the feed port, and the coil heats or cools the raw materials. At the same time, the motor drives the stirrer to stir the raw materials, and the pressure regulating valve adjusts the pressure inside the reactor body. Finally, the raw materials are discharged through the discharge port.

[0004] In the traditional reactor for the synthesis and preparation of L-menthol glyoxylate, when the raw materials are stirred and mixed and reacted, some raw materials or reactants will remain on the inner wall of the reactor, and the residual raw materials will be mixed into the final product as impurities during subsequent use, thereby affecting the purity and quality of the product. At the same time, the long-term existence of residual raw materials will cause scaling and corrosion inside the reactor. In order to solve the above problems, some reactors for the synthesis and preparation of L-menthol glyoxylate are equipped with a scraper on the stirring structure, and the scraper is tightly fitted with the inner wall of the reactor. When the scraper is driven to rotate, the residual raw materials on the inner wall of the reactor are cleaned. However, this method has limited cleaning effect due to the scraper alone, but for residues with high viscosity and strong adhesion, it is difficult to completely remove them by scraper alone. For this reason, a reactor for the synthesis and preparation of L-menthol glyoxylate is proposed. Utility Model Content

[0005] 1. Technical issues to be solved

[0006] In view of the shortcomings of the prior art, the utility model provides a reactor for the synthesis and preparation of L-menthol glyoxylate to solve the technical problem that it is difficult to completely remove the residues with high viscosity and strong adhesion only by scraping.

[0007] (II) Technical solution

[0008] In order to achieve the above-mentioned purpose, the utility model provides the following technical solution: a reactor for the synthesis and preparation of L-menthol glyoxylate, comprising:

[0009] The outer shell, and the feed funnel and the discharge pipe arranged on both sides of the outer shell are provided with a connecting cover plate on the top of the outer shell, and a pump body is installed at the top center of the connecting cover plate;

[0010] The column is arranged at the center of the bottom of the inner cavity of the outer shell, and a stirring rod is installed around the surface of the column. The front and rear ends of the top of the stirring rod are provided with a spray head, which is connected to the column, and the column is connected to the pump body. The column is connected to side scrapers around and fits tightly with the inner wall of the outer shell;

[0011] The rotating base is arranged at the center of the bottom of the inner cavity of the outer shell and connected to the column, and the bottom of the rotating base is coaxially connected to a driving motor. After the raw materials are discharged after reaction in the outer shell, the driving motor drives the column, the stirring rod and the side scraper to rotate through the rotating base, and the side scraper scrapes the residue on the inner wall of the outer shell, while the pump body is connected to the external cleaning water or chemical reagent to transport the liquid to the inside of the column and spray the liquid onto the inner wall of the outer shell through the spray head. On the one hand, by scraping the side scraper and spraying the liquid with the spray head, the residue with high viscosity and strong adhesion on the inner wall of the outer shell can be scraped off comprehensively, thereby ensuring the purity and quality of the product; on the other hand, the column can not only drive the stirring rod and the side scraper to rotate, but also transport the liquid to the spray head, which improves the practicality of the device.

[0012] Preferably, a connecting rod is installed on the upper part, the center and the lower part of the inner side surface of the side scraper, and a telescopic cylinder is added to the inner end of the connecting rod, and the telescopic cylinder is connected to the column. The column can drive the side scraper to rotate through the telescopic cylinder and the connecting rod.

[0013] Preferably, a compression spring is transversely arranged in the inner cavity of the telescopic cylinder, and the inner end of the connecting rod extends into the interior of the telescopic cylinder and fits tightly with the corresponding end of the compression spring. The compression spring squeezes the side scraper through the connecting rod in the inner cavity of the telescopic cylinder, so that the side scraper fits tightly with the inner wall of the outer shell, ensuring the scraping effect of the side scraper.

[0014] Preferably, a lifting plate is installed around the outer surface of the column, and the stirring rod is hinged to the column, the lifting plate is rotatably connected to the stirring rod, and an external resistance circular plate is installed on the top of the stirring rod and fits with the outer end of the injection head. When the lifting plate is lifted and lowered on the outer surface of the column, the stirring rod and the external resistance circular plate can be driven to adjust the pitch angle, and the external resistance circular plate is separated from the outer end of the injection head, so that the liquid can be sprayed outward through the injection head, avoiding the phenomenon that part of the raw materials or exhaust gas enters the column through the injection head when the raw materials are reacted.

[0015] Preferably, the surface of the lifting plate is connected to a limit sleeve, and the limit sleeve is connected to the column, and the bottom end of the lifting plate extends downward through the rotating base and is connected to the rotating end of the driving motor. The driving motor drives the rotating base and the rotating base to rotate through the lifting plate, and the lifting plate can only move up and down along the limit sleeve.

[0016] Preferably, a hydraulic rod is installed directly below the bottom of the driving motor, and the telescopic end of the hydraulic rod is connected to the bottom of the driving motor, and a support base is installed at the bottom of the hydraulic rod. The hydraulic rod drives the driving motor to perform lifting motion on the support base, so that the lifting plate can be adjusted.

[0017] (III) Beneficial effects

[0018] Compared with the prior art, the utility model provides a reactor for the synthesis and preparation of L-menthol glyoxylate, which has the following beneficial effects:

[0019] The reactor for the synthesis and preparation of L-menthol glyoxylate, after the reaction of the raw materials in the outer shell is completed and discharged, the driving motor drives the column, the stirring rod and the side scraper to rotate through the rotating base, and the side scraper scrapes the residue on the inner wall of the outer shell, and the pump body is connected to the external cleaning water or chemical reagent, and the liquid is transported to the inside of the column, and the liquid is sprayed onto the inner wall of the outer shell through the spray head. The column can not only drive the stirring rod and the side scraper to rotate, but also transport the liquid to the spray head, which improves the practicality of the device, and then the side scraper scrapes the residue. By scraping with the side scraper and spraying the liquid with the spray head, the residue with high viscosity and strong adhesion on the inner wall of the outer shell can be comprehensively scraped, thereby ensuring the purity and quality of the produced products. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0021] Figure 2 This is a schematic diagram of the internal structure of the outer shell of the utility model in cross section;

[0022] Figure 3 This is a schematic diagram of the column and its connection structure of the utility model;

[0023] Figure 4 This is a cross-sectional view of the telescopic cylinder of the utility model and a schematic diagram of its connection structure.

[0024] In the figure: 1. outer shell; 2. feed funnel; 3. discharge pipe; 4. connecting cover plate; 5. pump body; 6. column; 7. stirring rod; 8. injection head; 9. telescopic cylinder; 10. extrusion spring; 11. connecting rod; 12. side scraper; 13. lifting plate; 14. limit sleeve; 15. external resistance circular plate; 16. rotating base; 17. driving motor; 18. hydraulic rod; 19. supporting base. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] The utility model provides a technical solution, a reactor for the synthesis and preparation of L-menthol glyoxylate, comprising: Figure 1 , an outer shell 1, and a feed hopper 2 and a discharge pipe 3 arranged on both sides of the outer shell 1, a connecting cover plate 4 is added to the top of the outer shell 1, and a pump body 5 is installed at the top center of the connecting cover plate 4;

[0027] See also Figure 3 The column 6 is arranged at the center of the bottom of the inner cavity of the outer shell 1, and the surface of the column 6 is equipped with stirring rods 7, and the top of the stirring rod 7 is provided with a spray head 8 at the front and rear ends, and is connected with the column 6, and the column 6 is connected with the pump body 5, and the column 6 is connected with side scrapers 12 around it, and is tightly fitted with the inner wall of the outer shell 1;

[0028] See also Figure 2, a rotating base 16 is arranged at the center of the bottom of the inner cavity of the outer shell 1 and connected to the column 6, and a driving motor 17 is coaxially connected to the bottom of the rotating base 16. After the raw materials are reacted and discharged in the outer shell 1, the driving motor 17 drives the column 6, the stirring rod 7 and the side scraper 12 to rotate through the rotating base 16, and the side scraper 12 scrapes the residue on the inner wall of the outer shell 1, and the pump body 5 is connected to the external cleaning water or chemical reagent, and the liquid is transported to the inside of the column 6, and the liquid is sprayed onto the inner wall of the outer shell 1 through the spray head 8. On the one hand, by scraping the side scraper 12 and spraying the liquid by the spray head 8, the residue with high viscosity and strong adhesion on the inner wall of the outer shell 1 can be scraped off comprehensively, thereby ensuring the purity and quality of the produced product; on the other hand, the column 6 can not only drive the stirring rod 7 and the side scraper 12 to rotate, but also transport the liquid to the spray head 8, thereby improving the practicality of the device.

[0029] See also Figure 4 , the upper part, center and lower part of the inner side of the side scraper 12 are installed with a connecting rod 11, and the inner end of the connecting rod 11 is provided with a telescopic cylinder 9, and the telescopic cylinder 9 is connected to the column 6. The column 6 can drive the side scraper 12 to rotate through the telescopic cylinder 9 and the connecting rod 11. The inner cavity of the telescopic cylinder 9 is laterally provided with an extrusion spring 10, and the inner end of the connecting rod 11 extends into the interior of the telescopic cylinder 9 and fits tightly with the corresponding end of the extrusion spring 10. The extrusion spring 10 squeezes the side scraper 12 through the connecting rod 11 in the inner cavity of the telescopic cylinder 9, so that the side scraper 12 fits tightly with the inner wall of the outer shell 1, ensuring the scraping effect of the side scraper 12. The outer surface of the column 6 is equipped with a lifting plate 13 around it, and the stirring rod 7 is hinged to the column 6, the lifting plate 13 is rotatably connected to the stirring rod 7, and the top of the stirring rod 7 is equipped with an external resistance circular plate 15, which fits with the outer end of the injection head 8. When the lifting plate 13 is lifted and lowered on the outer surface of the column 6, it can drive the stirring rod 7 and the outer resistance circular plate 15 to adjust the pitch angle, and the outer resistance circular plate 15 is separated from the outer end of the injection head 8, so that the liquid can be sprayed outward through the injection head 8, avoiding the phenomenon that part of the raw materials or exhaust gas enters the column 6 through the injection head 8 when the raw materials are reacted. The surface of the lifting plate 13 is connected to the limit sleeve 14, and the limit sleeve 14 is connected to the column 6. The bottom end of the lifting plate 13 extends downward through the rotating base 16 and is connected to the rotating end of the driving motor 17. The driving motor 17 drives the rotating base 16 and the rotating base 16 to rotate through the lifting plate 13, and the lifting plate 13 can only move up and down along the limit sleeve 14.

[0030] See also Figure 2A hydraulic rod 18 is installed just below the bottom of the driving motor 17, and the telescopic end of the hydraulic rod 18 is connected to the bottom of the driving motor 17, and a supporting base 19 is installed at the bottom of the hydraulic rod 18. The hydraulic rod 18 drives the driving motor 17 to move up and down on the supporting base 19, so that the lifting plate 13 can be adjusted up and down.

[0031] This solution: After the raw materials are reacted and discharged in the outer shell 1, the driving motor 17 drives the column 6, the stirring rod 7 and the side scraper 12 to rotate through the rotating base 16, and the side scraper 12 scrapes the residue on the inner wall of the outer shell 1, and the pump body 5 is connected to the external cleaning water or chemical reagent, and the liquid is transported to the inside of the column 6, and the liquid is sprayed onto the inner wall of the outer shell 1 through the injection head 8. The extrusion spring 10 squeezes the side scraper 12 through the connecting rod 11 in the inner cavity of the telescopic cylinder 9, so that the side scraper 12 and the inner wall of the outer shell 1 fit tightly. The driving motor 17 drives the rotating base 16 to rotate through the lifting plate 13, and the hydraulic rod 18 drives the driving motor 17 to move up and down on the supporting base 19. When the lifting plate 13 is lifted and lowered on the outer surface of the column 6, it can drive the stirring rod 7 and the external resistance circular plate 15 to adjust the pitch angle, and the external resistance circular plate 15 is separated from the outer end of the injection head 8, so that the liquid can be sprayed out through the injection head 8.

[0032] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0033] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A reactor for the synthesis and preparation of L-menthol glyoxylate, characterized in that: include: An outer shell (1), and a feed hopper (2) and a discharge pipe (3) arranged on both sides of the outer shell (1). A connecting cover plate (4) is provided on the top of the outer shell (1), and a pump body (5) is installed at the center of the top of the connecting cover plate (4); The column (6) is arranged at the center of the bottom of the inner cavity of the outer shell (1), and a stirring rod (7) is installed around the surface of the column (6). The front and rear ends of the top of the stirring rod (7) are provided with a spray head (8) which is connected to the column (6), and the column (6) is connected to the pump body (5). The column (6) is connected to a side scraper (12) around the periphery and is tightly fitted with the inner wall of the outer shell (1); The rotating base (16) is arranged at the center of the bottom of the inner cavity of the outer shell (1) and is connected to the column (6), and the bottom of the rotating base (16) is coaxially connected to a driving motor (17).

2. A reactor for preparing L-menthol glyoxylate according to claim 1, characterized in that: A connecting rod (11) is installed on the upper part, the center and the lower part of the inner side surface of the side scraper (12), and a telescopic cylinder (9) is added to the inner end of the connecting rod (11), and the telescopic cylinder (9) is connected to the column (6).

3. A reactor for preparing the synthesis of L-menthol glyoxylate according to claim 2, characterized in that: The inner cavity of the telescopic cylinder (9) is laterally provided with an extrusion spring (10), and the inner end of the connecting rod (11) extends into the interior of the telescopic cylinder (9) and fits tightly with the corresponding end of the extrusion spring (10).

4. A reactor for preparing the synthesis of L-menthol glyoxylate according to claim 1, characterized in that: A lifting plate (13) is installed around the outer surface of the column (6), and the stirring rod (7) is hinged to the column (6). The lifting plate (13) is rotatably connected to the stirring rod (7), and an external resistance circular plate (15) is installed on the top of the stirring rod (7) and fits with the outer end of the injection head (8).

5. A reactor for preparing the synthesis of L-menthol glyoxylate according to claim 4, characterized in that: The surface of the lifting plate (13) is connected to a limiting sleeve frame (14), and the limiting sleeve frame (14) is connected to the column (6). The bottom end of the lifting plate (13) passes through the rotating base (16) and extends downward, and is connected to the rotating end of the driving motor (17).

6. A reactor for preparing the synthesis of L-menthol glyoxylate according to claim 5, characterized in that: A hydraulic rod (18) is installed directly below the bottom of the driving motor (17), and the telescopic end of the hydraulic rod (18) is connected to the bottom of the driving motor (17). A supporting base (19) is installed at the bottom of the hydraulic rod (18).

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