Pipette tip and pipette

Abstract

The utility model discloses a pipettor gun head and a pipettor. The pipettor gun head comprises a liquid suction part, a liquid storage part and a connecting part, wherein the first end of the liquid suction part is provided with a liquid suction port, the second end of the liquid suction part is fixedly connected with the first end of the liquid storage part, and the hole diameter of the liquid suction port is larger than that of the second end of the liquid suction part; the interior of the liquid storage part is communicated with the liquid suction port; the connecting part is arranged at the second end of the liquid storage part; the liquid storage part is used for being connected with a pipettor through the connecting part. And the liquid absorbing part is trumpet-shaped. The pipettor is provided with the pipettor gun head. According to the pipettor gun head, liquid with a target object can be conveniently sucked, the target object can conveniently enter the liquid storage part through the liquid suction part, the suction process of the target object can be simplified, the suction efficiency of the target object can be improved, and meanwhile the integrity of the shape and / or the structure of the target object is not prone to being damaged.

Description

Technical Field

[0001] The utility model belongs to the technical field of biomedicine, and particularly relates to a pipette tip and a pipette. Background Art

[0002] The pipette and the pipette tip are used in cooperation, and can quantitatively transfer a small amount or a trace amount of liquid according to experimental requirements, and are widely used in the biological and / or chemical fields. The pipette tip has different shapes and / or ranges (such as 10 μL (microliter), 200 μL, 1000 μL, 5 mL (milliliter), etc.) to be easily matched with pipettes of different specifications. The overall shape of the traditional pipette tip is usually a conical shape with a wider upper part and a narrower lower part. And the liquid suction port of the pipette tip is usually a sharp flat cut in a circular shape, and at the same time, the diameter of the liquid suction port is narrow. When sucking liquid, this structure can make the liquid in the cavity rise slowly, preventing the liquid from rising too fast during liquid suction and sucking the liquid into the pipette.

[0003] Organoids are a kind of miniature three-dimensional tissue cultures that can replicate the complex biological processes of human organs in vitro and play an indispensable role in precision medicine, disease modeling and regenerative medicine. Organoids are used as an important tool for scientific research. At present, researchers have successfully cultivated various organoid models, such as brain, retina, ovary, lung, liver, prostate, pancreas, breast, colon, kidney, heart and other organoids, and also include organoids of various cancer tissues, such as glioma, lung cancer, kidney cancer and other organoids. The diameter of most organoids is 50 - 300 μm, among which, the diameter of brain organoids and glioma organoids can reach 4000 μm. Organoids are small, soft and mostly spherical, and some organoids have irregular shapes. When conducting scientific experiments on organoids (such as high-throughput drug screening and / or organoid activity detection experiments), it is usually necessary to transfer single or multiple organoid spheres back and forth. However, the liquid suction port of the traditional pipette tip is relatively sharp and the aperture is relatively small. Using the traditional pipette tip to transfer organoids easily causes damage to the shape and structural integrity of the organoids, and / or it is not easy to aspirate the organoids, resulting in the failure of the experiment. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a pipette tip and a pipette for the deficiencies of the prior art.

[0005] To solve the above technical problems, the present utility model adopts the following technical solutions: A pipette tip, comprising: a liquid suction part, a liquid storage part and a connection part; wherein, a liquid suction port is provided at a first end of the liquid suction part, a second end of the liquid suction part is fixedly connected to a first end of the liquid storage part, and the aperture of the liquid suction port is larger than the aperture of the second end of the liquid suction part; the interior of the liquid storage part is communicated with the liquid suction port; the connection part is arranged at a second end of the liquid storage part; the liquid storage part is used to connect to a pipette through the connection part.

[0006] Further, the liquid suction part is arranged in a horn shape.

[0007] Further, the aperture of the liquid suction part gradually decreases from the liquid suction port to the second end of the liquid suction part.

[0008] Further, the transverse cross-section of the liquid suction part is circular.

[0009] Further, the liquid suction port is a flat cut, and a smooth arc-shaped structure is circumferentially arranged on the flat cut.

[0010] Further, the inner surface at the connection between the second end of the liquid suction part and the first end of the liquid storage part is a smooth arc-shaped transition surface.

[0011] Further, the aperture of the second end of the liquid suction part is 100 to 4000 microns.

[0012] Further, the included angle between the transverse end face of the second end of the liquid suction part and the circumferential outer wall of the liquid suction part is 25° to 65°.

[0013] Further, the liquid storage part includes: a conical cavity and a cylindrical cavity; wherein, the small-mouth end of the conical cavity is fixedly connected to the second end of the liquid suction part, the large-mouth end of the conical cavity opposite to the small-mouth end is fixedly connected to the axial first end of the cylindrical cavity, and the aperture of the large-mouth end of the conical cavity is less than or equal to the aperture of the cylindrical cavity; the connection part is arranged at the axial second end of the cylindrical cavity.

[0014] Further, the transverse cross-section of the conical cavity is circular, and the transverse cross-section of the cylindrical cavity is circular.

[0015] Further, the connection part includes a ground glass-like structure or a threaded structure arranged on the inner wall of the axial second end of the cylindrical cavity.

[0016] Further, an anti-slip-off structure is arranged on the outer wall of the second end of the liquid storage part.

[0017] A pipette having the pipette tip described above.

[0018] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0019] 1. The pipette tip of the present utility model is provided with a liquid suction part. A liquid suction port is arranged at the first end of the liquid suction part, and the aperture of the liquid suction port is larger than that of the second end of the liquid suction part, which can facilitate the suction of the liquid with the target substance, and facilitate the target substance to enter the liquid storage part through the liquid suction part. Furthermore, it can simplify the process of sucking the target substance, improve the efficiency of sucking the target substance, and is not easy to damage the shape and / or structural integrity of the target substance.

[0020] 2. The liquid suction part of the pipette tip of the present utility model is arranged in a horn shape, which can further facilitate the suction of the target substance and further facilitate the target substance to enter the liquid storage part through the liquid suction part.

[0021] 3. The aperture of the liquid suction part of the pipette tip of the present utility model gradually decreases from the liquid suction port to the second end of the liquid suction part, which can further facilitate the suction of the target substance and further facilitate the target substance to enter the liquid storage part through the liquid suction part, and has good aesthetics.

[0022] 4. The liquid suction port of the pipette tip of the present utility model is a flat cut, and a smooth arc structure is circumferentially arranged on the flat cut, which can further prevent the shape and / or structural integrity of the target substance from being damaged when sucking the target substance, and has good aesthetics.

[0023] 5. The inner surface of the connection between the second end of the liquid suction part and the first end of the liquid storage part of the pipette tip of the present utility model is a smooth arc transition surface, which can further facilitate the target substance to enter the liquid storage part through the second end of the liquid suction part, and can further prevent the shape and / or structural integrity of the target substance from being damaged.

[0024] 6. The liquid storage part of the pipette tip of the present utility model includes a conical cavity and a cylindrical cavity. The conical cavity can prevent the liquid flow rate from being too fast when sucking liquid, thereby preventing the target substance from being damaged, and the cylindrical cavity can facilitate the accommodation of more liquid.

[0025] 7. An anti-slip structure is arranged on the outer wall of the second end of the liquid storage part of the pipette tip of the present utility model, which can facilitate the production and boxing of the pipette tip.

[0026] 8. The pipette tip of the present utility model has a simple structure, is convenient to use, has a wide application range, and good economy. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 The cross-sectional schematic diagram showing a specific embodiment of the pipette tip of the present utility model;

[0028] Figure 2 The three-dimensional structural schematic diagram showing a specific embodiment of the pipette tip of the present utility model;

[0029] Figure 3 The schematic structural diagram of a specific embodiment of the liquid suction part of the pipette tip of the present utility model is shown.

[0030] Among them, 1 - liquid suction part; 11 - liquid suction port; 111 - smooth arc structure; 12 - the second end of the liquid suction part 1; 13 - circumferential outer wall; 2 - liquid storage part; 21 - conical cavity; 22 - cylindrical cavity; 211 - small - mouth end; 212 - large - mouth end; 3 - connecting part; 4 - smooth arc transition surface. Specific embodiments

[0031] The present utility model will be further described below in conjunction with the embodiments shown in the accompanying drawings.

[0032] Direction terms mentioned in the present utility model, such as "inner", "outer", "axial direction", "lateral direction", etc., are only in reference to the way of the accompanying drawings. Therefore, the direction terms used are for explaining and understanding the present utility model, rather than for limiting the present utility model.

[0033] As Figures 1 to 3 shown, the pipette tip of the present utility model includes: a liquid suction part 1, a liquid storage part 2, and a connecting part 3. Among them,

[0034] A liquid suction port 11 is provided at the first end of the liquid suction part 1. The second end 12 of the liquid suction part 1 is fixedly connected to the first end of the liquid storage part 2. The aperture of the liquid suction port 11 is larger than the aperture of the second end 12 of the liquid suction part 1.

[0035] The inside of the liquid storage part 2 is communicated with the liquid suction port 11. The connecting part 3 is provided at the second end of the liquid storage part 2. The liquid storage part 2 is used to connect to the pipette through the connecting part 3.

[0036] Among them, by making the aperture of the liquid suction port 11 larger than the aperture of the second end 12 of the liquid suction part 1, it is convenient to suck the liquid with the target (including organoids), and it is convenient for the target to enter the liquid storage part 2 through the liquid suction part 1. Furthermore, it can simplify the process of sucking the target, improve the sucking efficiency of the target, and at the same time, it is not easy to damage the shape and / or structural integrity of the target. The structure of this pipette tip is simple and easy to use.

[0037] In a specific embodiment, as Figures 1 to 3 shown, the liquid suction part 1 is arranged in a trumpet shape, which can further facilitate sucking the target and further facilitate the target to enter the liquid storage part 2 through the liquid suction part 1.

[0038] In a specific embodiment, as Figures 1 to 3As shown, the aperture diameter gradually decreases from the liquid suction port 11 of the liquid suction part 1 to the second end 12 of the liquid suction part 1, which can further facilitate the suction of the target object, and further facilitate the entry of the target object into the liquid storage part 2 through the liquid suction part 1, and has good aesthetics.

[0039] In a specific embodiment, as Figures 1 to 3 shown, the transverse cross-section of the liquid suction part 1 is circular, which can further facilitate the suction of the target object, and further facilitate the entry of the target object into the liquid storage part 2 through the liquid suction part 1. At the same time, the structure is simple and easy to use.

[0040] In a specific embodiment, as Figures 1 to 3 shown, the liquid suction port 11 is a flat cut, and a smooth arc structure 111 is circumferentially arranged on the flat cut, which can further prevent the shape and / or structural integrity of the target object from being damaged when sucking the target object (for example, preventing the structure of the organoid from being scratched), and has good aesthetics.

[0041] In a specific embodiment, as Figure 1 shown, the inner surface at the connection between the second end 12 of the liquid suction part 1 and the first end of the liquid storage part 2 is a smooth arc transition surface 4, which can further facilitate the entry of the target object into the liquid storage part 2 through the second end 12 of the liquid suction part 1, and can further prevent the shape and / or structural integrity of the target object from being damaged.

[0042] In a specific embodiment, as Figures 1 to 3 shown, the aperture diameter of the second end 12 of the liquid suction part 1 is 100 - 4000 microns, which can facilitate the entry of the target object into the liquid storage part 2 through the second end 12 of the liquid suction part 1 and prevent the shape and / or structural integrity of the target object from being damaged.

[0043] In a specific embodiment, as Figure 1 shown, the included angle θ between the transverse end face of the second end 12 of the liquid suction part 1 and the circumferential outer wall 13 of the liquid suction part 1 is 25° - 65°, which can facilitate the entry of the target object into the liquid storage part 2 through the second end 12 of the liquid suction part 1 and prevent the shape and / or structural integrity of the target object from being damaged.

[0044] In a specific embodiment, as Figures 1 to 3 shown, the liquid storage part 2 includes: a conical cavity 21 and a cylindrical cavity 22. Among them,

[0045] The small-mouth end 211 of the conical cavity 21 is fixedly connected to the second end 12 of the liquid suction part 1, and the large-mouth end 212 of the conical cavity 21 opposite to the small-mouth end 211 is fixedly connected to the axial first end of the cylindrical cavity 22. The aperture diameter of the large-mouth end 212 of the conical cavity 21 is less than or equal to the aperture diameter of the cylindrical cavity 22. The connecting part 3 is arranged at the axial second end of the cylindrical cavity 22.

[0046] Among them, by fixedly connecting the small-mouth end 211 of the conical cavity 21 to the second end 12 of the liquid suction part 1, and fixedly connecting the large-mouth end 212 of the conical cavity 21 to the first axial end of the cylindrical cavity 22, the liquid flow rate during liquid suction can be prevented from being too fast, thereby preventing the target in the liquid from being damaged. And the cylindrical cavity 22 can facilitate the accommodation of more liquid.

[0047] In a specific embodiment, as Figures 1 to 3 shown, the transverse cross-section of the conical cavity 21 is circular, which can further prevent the target in the liquid from being damaged, and has a simple structure and is convenient to use.

[0048] In a specific embodiment, as Figures 1 to 3 shown, the transverse cross-section of the cylindrical cavity 22 is circular, which can further facilitate the accommodation of more liquid, and has a simple structure and is convenient to use.

[0049] In a specific embodiment, as Figure 1 shown, the connecting part 3 includes a ground glass-like structure or a threaded structure provided on the inner wall of the second axial end of the cylindrical cavity 22, which can facilitate the tight connection between the pipette tip and the pipette, reduce the possibility of the pipette tip slipping off, and improve the airtightness at the same time.

[0050] In a specific embodiment, as Figures 1 to 3 shown, an anti-slip-off structure 5 is provided on the outer wall of the second end 12 of the liquid suction part 1, which can facilitate the production and boxing of the pipette tip.

[0051] When the pipette tip of the present utility model is in use, a liquid suction port 11 is provided at the first end of the liquid suction part 1. The aperture of the liquid suction port 11 is larger than the aperture of the second end 12 of the liquid suction part 1, which can facilitate the suction of the liquid with the target, and facilitate the target to enter the liquid storage part 2 through the liquid suction part 1. Furthermore, the suction process of the target can be simplified, the suction efficiency of the target can be improved, and at the same time, the shape and / or structural integrity of the target is not easily damaged. The liquid suction part 1 is arranged in a flared shape, and the aperture of the liquid suction part 1 gradually decreases from the liquid suction port 11 to the second end 12 of the liquid suction part 1, which can further facilitate the suction of the target, and further facilitate the target to enter the liquid storage part 2 through the liquid suction part 1, and has good aesthetics.

[0052] On the basis of the above embodiments, the present utility model also proposes a pipette having the pipette tip described above. Among them, this pipette can simplify the target suction process, improve the target suction efficiency, and at the same time, the shape and / or structural integrity of the target is not easily damaged.

[0053] The protection scope of the present utility model is not limited to the above embodiments. Obviously, those skilled in the art can make various modifications and deformations to the present utility model without departing from the scope and spirit of the present utility model. If these modifications and deformations fall within the scope of the claims of the present utility model and its equivalent technologies, the intention of the present utility model also includes these modifications and deformations.

Claims

1. A pipette tip, characterized in that: include: A liquid absorbing part (1), a liquid storing part (2) and a connecting part (3); wherein, The first end of the liquid suction part (1) is provided with a liquid suction port (11), the second end (12) of the liquid suction part (1) is fixedly connected to the first end of the liquid storage part (2), and the aperture of the liquid suction port (11) is larger than the aperture of the second end (12) of the liquid suction part (1); The interior of the liquid storage part (2) is in communication with the liquid aspiration port (11); the connecting part (3) is arranged at the second end of the liquid storage part (2); and the liquid storage part (2) is used to connect a pipette via the connecting part (3).

2. The pipette tip according to claim 1, characterized in that: The liquid suction part (1) is configured to be trumpet-shaped.

3. The pipette tip according to claim 2, characterized in that: The aperture from the liquid suction port (11) of the liquid suction part (1) to the second end (12) of the liquid suction part (1) gradually decreases.

4. The pipette tip according to claim 2, characterized in that: The transverse cross section of the liquid absorbing part (1) is circular.

5. The pipette tip according to claim 1, characterized in that: The liquid suction port (11) is a flat incision, and a smooth arc-shaped structure (111) is circumferentially arranged on the flat incision.

6. The pipette tip according to claim 1, characterized in that: The inner surface of the connection between the second end (12) of the liquid absorbing part (1) and the first end of the liquid storing part (2) is a smooth arc-shaped transition surface (4).

7. The pipette tip according to claim 1, characterized in that: The pore diameter of the second end (12) of the liquid absorbing part (1) is 100 to 4000 micrometers.

8. The pipette tip according to claim 1, characterized in that: The included angle between the transverse end surface of the second end (12) of the liquid absorbing portion (1) and the circumferential outer wall (13) of the liquid absorbing portion (1) is 25° to 65°.

9. The pipette tip according to claim 1, characterized in that: The liquid storage part (2) comprises: a conical cavity (21) and a columnar cavity (22); wherein: The small-mouth end (211) of the conical cavity (21) is fixedly connected to the second end (12) of the liquid suction portion (1); the large-mouth end (212) of the conical cavity (21) opposite to the small-mouth end (211) is fixedly connected to the axial first end of the columnar cavity (22); the aperture of the large-mouth end (212) of the conical cavity (21) is smaller than or equal to the aperture of the columnar cavity (22); and the connecting portion (3) is arranged at the axial second end of the columnar cavity (22).

10. The pipette tip according to claim 9, characterized in that: The transverse cross-section of the conical cavity (21) is circular, and the transverse cross-section of the cylindrical cavity (22) is circular.

11. The pipette tip according to claim 9, characterized in that: The connecting portion (3) comprises a ground glass-like structure or a threaded structure arranged on the inner wall of the second axial end of the cylindrical cavity (22).

12. The pipette tip according to claim 1, characterized in that: An anti-slip structure (5) is provided on the outer wall of the second end of the liquid storage portion (2).

13. A pipette, characterized in that: A pipette tip according to any one of claims 1 to 12.

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