Automatic microscope detection system
By designing an automatic microscope detection system, automatic preparation and detection of slide samples are achieved, and the problems of low detection efficiency and excessive manual intervention of existing equipment are solved, and the detection efficiency and degree of automation are improved.
Patent Information
- Application Number
- CN202422100437.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-28
- Publication Date
- 2025-05-27
- Estimated Expiration
- 2034-08-28
AI Technical Summary
Some existing automatic microscope detection equipment requires a lot of manual intervention during sample detection, resulting in inefficient detection.
An automatic microscope detection system is designed to realize automatic preparation, replacement and detection of slide samples through the combination of slide supply assembly, drop sample assembly, coverslip supply assembly and slide sample station moving assembly, thereby reducing manual intervention.
It improves the detection efficiency, reduces the workload of personnel participation, and meets the need to avoid a large number of manual interventions when testing samples.
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Figure CN222913505U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of sewage detection instrument equipment, and particularly relates to an automatic microscope detection system. Background Art
[0002] A microscope detection device is a technology that uses optical or electronic instruments to observe small objects that are invisible or unclear to the naked eye. With the development of science and technology, the functions of this technology have become increasingly powerful. It has a wide range of applications in multiple disciplines such as materials science, biological research, environmental science, medical diagnosis, education, and industrial applications, and has become an indispensable device in the field of sewage detection instrument equipment.
[0003] At present, ordinary automatic microscope detection devices on the market are mainly automated and are convenient to use. However, their disadvantage is that their automation is only partial. It is only automatic when the stage moves the glass slide sample for detection, and the preparation and replacement of each glass slide sample require manual intervention operations, which increases the workload of personnel and lengthens the time for detecting samples. Therefore, when detecting samples, in situations where it is necessary to improve the detection efficiency and avoid a large amount of manual intervention operations, some existing automatic microscope detection devices cannot meet the requirements. Summary of the Utility Model
[0004] The problem to be solved by the utility model is to provide an automatic microscope detection system, which improves the detection efficiency and reduces the workload of personnel involved by increasing the degree of automation in the preparation and replacement of glass slide samples.
[0005] To solve the above problems, the utility model provides an automatic microscope detection system. To achieve the above purpose, the technical solution adopted by the utility model to solve its technical problems is as follows:
[0006] On the one hand, an automatic microscope detection system includes: a glass slide supply component, including a plurality of stacked glass slides; a sample dropping component, including a dropper component capable of dropping sample droplets on the upper surface of the glass slide; a cover glass supply component, outputting cover glasses, and the cover glass supply component includes a cover glass seat that obliquely guides the cover glass to the upper surface of the glass slide; the cover glass and the glass slide that jointly contact the sample droplets together form a glass slide sample; a microscope component, magnifying the image of the glass slide sample; a glass slide sample station moving component, with the glass slide supply component, the sample dropping component, the cover glass supply component, and the microscope component arranged in sequence unidirectionally; the glass slide sample station moving component includes a transfer insert plate, the length of the transfer insert plate is not less than the distance from the glass slide supply component to the microscope component, and the transfer insert plate can intermittently convey the glass slide and / or the glass slide sample.
[0007] As a further improvement of the present utility model, one side of the transfer inserting plate includes a plurality of outwardly protruding teeth, and the gaps formed between adjacent teeth can contact and limit the edges of the glass slide and / or the glass slide sample.
[0008] As a further improvement of the present utility model, the transfer inserting plate altogether includes four gaps, which are arranged at equal intervals; a cover glass baffle is fixed to the edge of one of the gaps, and the cover glass baffle can contact and limit the edge of the cover glass; the transfer inserting plate includes a horizontal transverse linear mechanical degree of freedom and a horizontal longitudinal linear mechanical degree of freedom, the direction of the horizontal transverse linear mechanical degree of freedom is parallel to the opening direction of the gap, and the connection direction from the glass slide supply component to the microscope component is parallel to the direction of the horizontal longitudinal linear mechanical degree of freedom.
[0009] As a further improvement of the present utility model, the glass slide supply component includes a glass slide box, a plurality of glass slides are vertically stacked in a stack in the glass slide box, and the bottom of the glass slide box has an opening.
[0010] As a further improvement of the present utility model, a servo component and a peristaltic pump are assembled on the outer wall of the dropper component in the sample dropping component, the servo component can drive one end of the dropper component to move, and the servo component has a swinging mechanical degree of freedom around the space vertical line; the sample dropping component further includes a sample container, and the peristaltic pump can suck the sample from the sample container by one end of the dropper component; an electric push rod component is in contact with the lower part of the sample container, and the electric push rod component drives the sample container to move, and the sample container has a vertical lifting mechanical degree of freedom.
[0011] As a further improvement of the present utility model, the cover glass supply component includes a cover glass box, a plurality of cover glasses are vertically stacked in a stack in the cover glass box, and the bottom of the cover glass box has an opening; the cover glass supply component includes a cover glass push plate, and the cover glass push plate has a horizontal reciprocating translation mechanical degree of freedom, and the cover glass push plate can push out the cover glass at the bottom in the cover glass box.
[0012] As a further improvement of the present utility model, the cover glass supply component includes a stepping motor, and the stepping motor is hinged to one end of the cover glass push plate through a rotating rod; the upper surface of the cover glass seat has an inclined linear groove capable of guiding the cover glass, and along the direction away from the cover glass box, the height of the linear groove gradually decreases.
[0013] As a further improvement of the present utility model, a stage component is further arranged below the transfer inserting plate, and the upper surface of the stage component can hold the glass slide and / or the glass slide sample; the stage component has a vertically penetrating liquid leakage hole.
[0014] As a further improvement of the present utility model, a light source component is arranged below the stage component, the light source component is directly below the microscope component, and the stage component includes a light leakage hole through which the light of the light source component passes.
[0015] As a further improvement of the present utility model, a waste collection assembly is further provided below the stage assembly. The waste collection assembly includes a collection tank and a collection bucket; the collection tank is directly below the liquid leakage hole; a collection bucket is arranged below the outer side of one end of the stage assembly adjacent to the microscope assembly.
[0016] The beneficial effects of adopting the automatic microscope detection system of the present application are as follows: This technical solution is mainly applied to the field of sewage detection instrument equipment, providing an automatic solution for multi-disciplinary observation and detection of tiny objects. It can meet the requirement of avoiding a large amount of manual intervention operations while detecting samples, and can also improve the detection efficiency.
[0017] Based on the ordinary automatic microscope detection equipment, this patent solution further increases the automation of the slide sample preparation and replacement links, and optimizes the equipment working process.
[0018] Based on the ordinary automatic microscope detection equipment, this technical solution realizes the automatic supply of slides through the slide supply assembly, realizes the automatic dripping of sample liquid onto the slide according to the required amount through the sample dripping assembly, realizes the automatic supply and covering of the cover glass onto the slide through the cover glass supply assembly, and the slide sample station moving assembly runs through the entire automated working process, pushing the slide sample to move among various stations. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.
[0020] Figure 1 is an exploded view of an implementation manner of the present utility model;
[0021] Figure 2 is a partial enlarged view of the first station, the second station, the third station, and the fourth station of an implementation manner of the present utility model;
[0022] Figure 3 is a three-dimensional view of the microscope three-axis moving assembly of an implementation manner of the present utility model;
[0023] Figure 4 is a three-dimensional view of the slide sample station moving assembly of an implementation manner of the present utility model;
[0024] Figure 5 is a three-dimensional view of the slide supply assembly of an implementation manner of the present utility model;
[0025] Figure 6 is a perspective view of a sample dropping component according to an embodiment of the present utility model;
[0026] Figure 7 is a perspective view of a cover glass supply component according to an embodiment of the present utility model;
[0027] Figure 8 is a perspective view according to an embodiment of the present utility model;
[0028] Figure 9 is a perspective view according to an embodiment of the present utility model;
[0029] Figure 10 is a perspective view according to an embodiment of the present utility model;
[0030] Figure 11 is an application schematic diagram according to an embodiment of the present utility model.
[0031] 1 - mounting base plate;
[0032] 2 - microscope three-axis movement component; 21 - X-axis movement component; 22 - Y-axis movement component; 23 - Z-axis movement component; 24 - support frame;
[0033] 3 - microscope component;
[0034] 4 - stage component; 41 - liquid leakage hole;
[0035] 5 - slide sample station movement component; 51 - X-axis guide rail; 52 - Y-axis guide rail; 53 - transfer insert plate; 54 - movement component bracket; 55 - cover glass baffle; 56 - tooth;
[0036] 6 - slide supply component; 61 - slide box; 62 - slide seat;
[0037] 7 - sample dropping component; 71 - electric push rod component; 72 - peristaltic pump; 73 - servo component; 74 - dropper component; 75 - dropper component bracket; 76 - sample container;
[0038] 8 - cover glass supply component; 81 - cover glass box; 82 - stepper motor; 83 - cover glass push plate; 84 - cover glass seat; 85 - cover glass component bracket;
[0039] 9 - waste collection component; 91 - collection trough; 92 - collection bucket;
[0040] 10 - electric control board;
[0041] 11 - light source component;
[0042] G1 - first station; G2 - second station; G3 - third station; G4 - fourth station;
[0043] ZB - Slide; GB - Coverslip. Detailed implementation mode
[0044] The following combines specific embodiments to further elaborate on the content of the present utility model:
[0045] To achieve the purpose of the present utility model, an automatic microscope detection system includes: a slide supply component 6, including a plurality of stacked slides ZB; a sample dropping component 7, including a dropper component 74 capable of dropping a sample liquid droplet onto the upper surface of the slide ZB; a coverslip supply component 8, outputting a coverslip GB, and the coverslip supply component 8 includes a coverslip seat 84 that obliquely guides the coverslip GB to the upper surface of the slide ZB; the coverslip GB and the slide ZB that jointly contact the sample liquid droplet together form a slide sample; a microscope component 3, magnifying the image of the slide sample; wherein the slide supply component 6, the sample dropping component 7, the coverslip supply component 8, and the microscope component 3 are arranged unidirectionally in sequence; the slide sample station moving component 5 includes a transfer insert 53, the length of the transfer insert 53 is not less than the distance from the slide supply component 6 to the microscope component 3, and the transfer insert 53 can intermittently convey the slide ZB and / or the slide sample.
[0046] As Figure 4 shown, in some other embodiments of the present utility model, one side of the transfer insert 53 includes a plurality of outwardly protruding teeth 56, and the gaps formed between adjacent teeth 56 can contact and limit the edges of the slide ZB and / or the slide sample.
[0047] The beneficial effect of adopting the above technical solution is that the gap provides a semi - enclosed accommodation for each slide ZB and / or slide sample, and the teeth 56 push them to move.
[0048] As Figure 4 shown, in some other embodiments of the present utility model, the transfer insert 53 altogether includes four gaps, and the four gaps are arranged at equal intervals; a coverslip baffle 55 is fixed to the edge of one of the gaps, and the coverslip baffle 55 can contact and limit the edge of the coverslip GB; the transfer insert 53 includes a horizontal transverse linear mechanical degree of freedom and a horizontal longitudinal linear mechanical degree of freedom, the direction of the horizontal transverse linear mechanical degree of freedom is parallel to the opening direction of the gap, and the connection direction from the slide supply component 6 to the microscope component 3 is parallel to the direction of the horizontal longitudinal linear mechanical degree of freedom.
[0049] The beneficial effect of adopting the above technical solution is that the longitudinal movement of the transfer insert 53 is to push the slide ZB and / or the slide sample to change positions, and the transverse movement of the transfer insert 53 is to extract and replace the specific teeth 56.
[0050] AsFigure 5 As shown, in some other embodiments of the present utility model, the slide supply assembly 6 includes a slide box 61, and a number of slides ZB are vertically stacked in a stack in the slide box 61, and the bottom of the slide box 61 has an opening.
[0051] The beneficial effect of adopting the above technical solution is that the discharging mode of the slides ZB is that the lowermost slide ZB is output one by one each time, and due to gravity, the original second-to-lowermost slide ZB becomes the lowermost slide ZB, and so on.
[0052] As Figure 6 shown, in some other embodiments of the present utility model, a servo motor assembly 73 and a peristaltic pump 72 are assembled on the outer wall of the dropper assembly 74 in the sample dropping assembly 7. The servo motor assembly 73 can drive one end of the dropper assembly 74 to move, and the servo motor assembly 73 has a swinging mechanical degree of freedom around the space vertical line; the sample dropping assembly 7 further includes a sample container 76. The peristaltic pump 72 can suck the sample from the sample container 76 with one end of the dropper assembly 74; an electric push rod assembly 71 is in contact with the lower part of the sample container 76, and the electric push rod assembly 71 drives the sample container 76 to move, and the sample container 76 has a vertical lifting mechanical degree of freedom.
[0053] The beneficial effect of adopting the above technical solution is that the peristaltic pump 72 can accurately move the liquid sample in the sample dropping assembly 7 in a small amount, and then control the specific number of drops onto the slide ZB. The sample container 76 can be a beaker and can correspondingly hold a relatively large amount of sample.
[0054] As Figure 7 shown, in some other embodiments of the present utility model, the cover glass supply assembly 8 includes a cover glass box 81, and a number of cover glasses GB are vertically stacked in a stack in the cover glass box 81, and the bottom of the cover glass box 81 has an opening; the cover glass supply assembly 8 includes a cover glass push plate 83, and the cover glass push plate 83 has a horizontal reciprocating translation mechanical degree of freedom, and the cover glass push plate 83 can push out the cover glass GB at the bottom in the cover glass box 81.
[0055] The beneficial effect of adopting the above technical solution is that the cover glasses GB are discharged one by one, just like the slides ZB, in one-to-one correspondence.
[0056] As Figure 7 shown, in some other embodiments of the present utility model, the cover glass supply assembly 8 includes a stepping motor 82, and the stepping motor 82 is hinged to one end of the cover glass push plate 83 through a rotating rod; the upper surface of the cover glass seat 84 has an inclined linear groove capable of guiding the cover glass GB, and along the direction away from the cover glass box 81, the height of the linear groove gradually decreases.
[0057] The beneficial effects of adopting the above technical solution are as follows: Different from the glass slide ZB, the cover glass GB falls obliquely downward and finally covers the glass slide ZB in a horizontal state. This feeding method has a small impact force and is also convenient for discharging the air between the glass slide ZB and the cover glass GB.
[0058] As Figure 1 shown, in some other embodiments of the present utility model, a stage assembly 4 is further provided below the transfer insertion plate 53. The upper surface of the stage assembly 4 can support the glass slide ZB and / or the glass slide sample; the stage assembly 4 is provided with a vertically penetrating liquid leakage hole 41.
[0059] The beneficial effects of adopting the above technical solution are as follows: The stage assembly 4 provides bottom support for all the glass slides ZB and / or the glass slide samples, and the notch of the transfer insertion plate 53 serves as the limiting basis for the side edges of all the glass slides ZB and / or the glass slide samples. If the sample liquid drips out, it will flow away through the liquid leakage hole 41.
[0060] As Figure 1 shown, in some other embodiments of the present utility model, a light source assembly 11 is provided below the stage assembly 4. The light source assembly 11 is located directly below the microscope assembly 3. The stage assembly 4 includes a light leakage hole through which the light of the light source assembly 11 passes; a waste collection assembly 9 is further provided below the stage assembly 4. The waste collection assembly 9 includes a collection trough 91 and a collection barrel 92; the collection trough 91 is located directly below the liquid leakage hole 41; the collection barrel 92 is provided below the outer side of one end of the stage assembly 4 adjacent to the microscope assembly 3.
[0061] The beneficial effects of adopting the above technical solution are as follows: The light source assembly 11 provides appropriate illumination intensity for the microscope assembly 3, and the waste collection assembly 9 is used to collect waste to ensure the long-term cleanliness of the detection operation area. The collection trough 91 is used to collect the liquid during the detection operation, and the collection barrel 92 is used to collect the entire glass slide sample after the detection operation is completed.
[0062] A detection method, including the automatic microscope detection system mentioned above, includes: Step S1, the slide supply component 6 is located at the first station G1, and slides ZB are discharged one by one from the slide box 61; Step S2, the sample droplet component 7 is located at the second station G2, and sample liquid droplets are dropped onto the upper surface of the slide ZB; Step S3, the coverslip supply component 8 is located at the third station G3, and the coverslip supply component 8 covers the slide ZB with a sample liquid droplet with a coverslip GB; Step S4, the microscope component 3 is located at the fourth station G4, and the microscope component 3 magnifies the object image of the slide sample; Step S5, the slide sample that has been magnified in object image and has completed microscopic observation at the fourth station G4 is discharged and collected; wherein, a single slide ZB sequentially undergoes Step S1, Step S2, Step S3, Step S4, and Step S5; within the same time, Step S1, Step S2, Step S3, Step S4, and Step S5 are synchronously and intermittently performed.
[0063] The beneficial effects of adopting the above technical solution are: enabling the device to perform corresponding process operations on slide samples at four stations simultaneously. Optimizing the device work process enables the device to perform corresponding process operations on slide samples at four stations simultaneously, so as to avoid a large amount of manual intervention operations during sample detection and improve the detection efficiency. Each time the transfer insert 53 moves, one operation is performed corresponding to each of the four stations.
[0064] As Figure 8 As shown, the installation base plate 1 is placed on the laboratory table, and the rest of the components are integrated on the installation base plate 1; the microscope three-axis movement component 2 is installed at the middle and rear position of the installation base plate 1; the stage component 4 is installed at the middle position of the installation base plate 1; the slide sample station movement component 5 is installed at the middle and front position of the installation base plate 1; the microscope component 3 is installed on the microscope three-axis movement component 2; the waste collection component 9 is installed on the left side and below the stage component 4; the slide supply component 6, the sample droplet component 7, and the coverslip supply component 8 are installed above the stage component 4 in sequence from right to left; the microscope three-axis movement component 2, the slide sample station movement component 5, the slide supply component 6, the sample droplet component 7, and the coverslip supply component 8 are the core functional components of the entire device; the electronic control board 10 is installed at the front and right position of the installation base plate 1.
[0065] As Figure 9As shown in the figure, the microscope three-axis movement assembly 2 mainly consists of an X-axis movement assembly 21, a Y-axis movement assembly 22, and a Z-axis movement assembly 23. The X-axis movement assembly 21 is installed on the support frame 24 and fixed to the mounting base plate 1 through the support frame 24; the Y-axis movement assembly 22 is installed on the X-axis movement assembly 21, and the Z-axis movement assembly 23 is installed on the Y-axis movement assembly 22; the function of the microscope three-axis movement assembly 2 is to enable the microscope assembly 3 installed on the microscope three-axis movement assembly 2 to move along the X, Y, and Z axes, so as to achieve full coverage of all positions to be inspected of the test sample. The sample dropping assembly 7 mainly consists of an electric push rod assembly 71, a peristaltic pump 72, a servo motor assembly 73, and a dropper assembly 74. The electric push rod assembly 71 is installed below the dropper assembly support 75 and fixed to the stage assembly 4 through the dropper assembly support 75, and its function is to enable the sample container placed on it to perform a lifting movement; both ends of the dropper assembly 74 are connected to the peristaltic pump 72 and the servo motor assembly 73, and its function is to provide a pipeline channel for transferring the sample liquid; the peristaltic pump 72 is installed behind the dropper assembly support 75 and fixed to the stage assembly 4 through the dropper assembly support 75, and its function is to generate suction so that the sample liquid in the dropper assembly 74 can flow in the required direction; the servo motor assembly 73 is installed in front of the dropper assembly support 75 and fixed to the stage assembly 4 through the dropper assembly support 75, and its function is to enable the dropper assembly 74 to reach the specified required position by rotating a fixed angle.
[0066] As Figure 10 shown in the figure, the slide sample station movement assembly 5 mainly consists of an X-axis guide rail 51, a Y-axis guide rail 52, a transfer plug board 53, and a movement assembly support 54. The X-axis guide rail 51 is installed on the movement assembly support 54 and fixed to the mounting base plate 1 through the movement assembly support 54; the Y-axis guide rail 52 is installed on the X-axis guide rail 51, and its function is to enable the transfer plug board 53 installed on the Y-axis guide rail 52 to move along the X and Y axes, so as to achieve the movement of the slide sample station movement assembly 5 as required; the transfer plug board 53 is installed on the Y-axis guide rail 52.
[0067] Four stations are demarcated on the transfer plug board 53, namely the first station G1, the second station G2, the third station G3, and the fourth station G4, and its function is to directly push up to four slide samples at most to move to the next station and perform positioning.
[0068] The slide supply assembly 6 is mainly composed of a slide box 61 and a slide holder 62. The slide holder 62 is installed and fixed on the stage assembly 4, and its function is to install and fix the slide box 61; the slide box 61 contains slides ZB, and its function is to store the slides ZB for use. The coverslip supply assembly 8 is mainly composed of a coverslip box 81, a stepper motor 82, a coverslip pusher 83, a coverslip holder 84, and a coverslip assembly bracket 85. The coverslip holder 84 is installed and fixed on the stage assembly 4, and its function is to install and fix the coverslip box 81; the coverslip box 81 contains coverslips GB, and its function is to store the coverslips GB for use; the coverslip pusher 83 is installed on the stepper motor 82, and its function is to push the coverslip GB out of the coverslip box 81 by moving back and forth; the stepper motor 82 is installed on the coverslip assembly bracket 85 and fixed to the stage assembly 4 through the coverslip assembly bracket 85. Its rotating part is connected to the coverslip pusher 83, and its function is to make the coverslip pusher 83 move back and forth by rotating.
[0069] The working principle of the entire detection system is as follows:
[0070] Manually install and fix the slide box 61 containing several slides ZB on the slide holder 62 for use, and install and fix the coverslip box 81 containing several coverslips ZB on the coverslip holder 84 for use. The number of coverslips GB for use in the coverslip box 81 can be adjusted as needed. One manual installation can cover the amount required for multiple detection tests.
[0071] Then place the sample container 76 containing the liquid sample to be tested on the electric push rod assembly 71. When the device starts to work, the electronic control board 10 is activated, and the electric push rod assembly 71 pushes the sample container 76 upward to the dropper assembly 74. The peristaltic pump 72 starts to work, sucks the sample liquid from the sample container 76 to fill the entire dropper assembly 74, and stops working until the excess sample liquid flows back to the sample container 76, ensuring that there is no excess air in the entire dropper assembly 74, which may cause too much or too little sample liquid to be dropped on the slide sample.
[0072] Then, as Figure 11 shown, the electric push rod assembly 71 pulls the sample container 76 downward and back away from the dropper assembly 74. Then the servo motor assembly 73 starts to rotate, drives the dropper assembly 74 to rotate to the sample dropping station above the stage assembly 4 and stops. Then the X-axis guide rail 51 and the Y-axis guide rail 52 start to move according to Figure 11Starting from the label of the first state, move in a cycle according to the view label order and arrow direction of the first state, the second state, the third state, and the fourth state until the view label ends, driving the transfer plate 53 to move, and pushing a slide ZB in the slide box 61 at the first station G1 on the transfer plate 53 below the dropper assembly 74. When the transfer plate 53 completes a cycle of movement, the slide ZB below the dropper assembly 74 is at the second station G2 of the transfer plate 53. Then the peristaltic pump 72 starts to work in reverse, making the suction outlet on the dropper assembly 74 become a drip outlet, changing the flow direction of the sample liquid therein. When the sample liquid is dripped onto the slide ZB in the required amount, the peristaltic pump 72 stops working. Then the X-axis guide rail 51 and the Y-axis guide rail 52 start to move according to Figure 11 the order of the four view labels and the arrow direction in the middle and move another cycle, driving the transfer plate 53 to move, pushing the slide ZB with the sample liquid dripped at the second station G2 of the transfer plate 53 below the cover glass supply assembly 8, and at the same time pushing a slide ZB in the slide box 61 at the first station G1 on the transfer plate 53 below the dropper assembly 74. When the transfer plate 53 completes a cycle of movement, the slide ZB below the dropper assembly 74 is at the second station G2 of the transfer plate 53, and the slide ZB below the cover glass supply assembly 8 is at the third station G3 of the transfer plate 53.
[0073] Then the stepping motor 82 rotates one circle, driving the cover glass pusher 83 to move back and forth, pushing out a cover glass GB from the cover glass box 81, and making the cover glass GB slide down along the slope on the cover glass seat 84 to cover the slide ZB with the sample liquid dripped. At the same time, the dropper assembly 74 repeats the above-mentioned sample dripping process. Then the X-axis guide rail 51 and the Y-axis guide rail 52 start to move according to Figure 11 the arrow direction in the middle and move another cycle, driving the transfer plate 53 to move, pushing the slide ZB covered with the cover glass GB at the third station G3 of the transfer plate 53 below the microscope assembly 3, and at the same time pushing the slide ZB with the sample liquid dripped at the second station G2 of the transfer plate 53 below the cover glass supply assembly 8, and pushing a slide ZB in the slide box 61 at the first station G1 on the transfer plate 53 below the dropper assembly 74. When the transfer plate 53 completes a cycle of movement, the slide ZB below the dropper assembly 74 is at the second station G2 of the transfer plate 53, the slide ZB below the cover glass supply assembly 8 is at the third station G3 of the transfer plate 53, and the slide ZB below the microscope assembly 3 is at the fourth station G4 of the transfer plate 53. Driven by the microscope three-axis movement assembly 2, the microscope assembly 3 detects the slide sample. At the same time, the dropper assembly 74 repeats the above-mentioned sample dripping process, and the cover glass supply assembly 8 repeats the above-mentioned cover glass process.
[0074] Then the X-axis guide rail 51 and the Y-axis guide rail 52 start to move according toFigure 11 Move one more cycle according to the view number sequence and arrow direction, drive the transfer plate 53 to move, push out the glass slide ZB that has completed the detection at the fourth station G4 of the transfer plate 53 from the left side of the stage assembly 4 until it falls into the waste collection assembly 9. At the same time, push the glass slide ZB covered with the cover glass GB at the third station G3 of the transfer plate 53 under the microscope assembly 3, push the glass slide ZB with the sample liquid dropped at the second station G2 of the transfer plate 53 under the cover glass supply assembly 8, and push a glass slide ZB in the glass slide box 61 at the first station G1 on the transfer plate 53 under the dropper assembly 74. The equipment can perform corresponding process operations on the glass slide samples at up to four stations simultaneously, and so on in a cycle.
[0075] Through optimized design, the glass slide sample station moving assembly 5 of this technical solution is only composed of the X-axis guide rail 51, the Y-axis guide rail 52, the transfer plate 53, and the moving assembly bracket 54. The glass slide supply assembly 6 is only composed of the glass slide box 61 and the glass slide seat 62. The sample dropping assembly 7 is only composed of the electric push rod assembly 71, the peristaltic pump 72, the servo motor assembly 73, and the dropper assembly 74. The cover glass supply assembly 8 is only composed of the cover glass box 81, the stepping motor 82, the cover glass push plate 83, the cover glass seat 84, and the cover glass assembly bracket 85. This greatly reduces the types of components, reduces the risk of failure that is extremely likely to occur in the relatively complex component structures, improves the reliability of the equipment operation, and also reduces the production cost of the equipment.
[0076] The above embodiments are only for illustrating the technical concept and features of the present invention. The purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it, and it cannot be used to limit the protection scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims
1. An automatic microscope detection system, characterized in that: include: A slide supply assembly, comprising a plurality of stacked slides; A sample dropping assembly, comprising a dropper assembly capable of dropping sample droplets onto the upper surface of the slide; A cover glass supply assembly outputs the cover glass, wherein the cover glass supply assembly includes a cover glass seat for obliquely guiding the cover glass to the upper surface of the slide glass; the cover glass and the slide glass that are in contact with the sample droplet together constitute a slide glass sample; Microscope components, which magnify the image of the slide sample; A slide sample station moving component, wherein the slide supply component, the sample drop component, the cover glass supply component, and the microscope component are arranged in one direction in sequence; the slide sample station moving component includes a transfer plug, the length of the transfer plug is not less than the distance from the slide supply component to the microscope component, and the transfer plug can intermittently transfer slides and / or slide samples.
2. The automatic microscope detection system according to claim 1, characterized in that: One side of the transfer plug plate includes a plurality of outwardly protruding shifting teeth, and the gaps formed between adjacent shifting teeth can contact and limit the edge of the slide glass and / or the slide glass sample.
3. The automatic microscope detection system according to claim 2, characterized in that: The transfer plug plate comprises four notches in total, and the four notches are arranged at equal intervals; A cover glass baffle is fixed to the edge of one of the gaps, and the cover glass baffle can contact and limit the edge of the cover glass; The transfer plug plate includes horizontal transverse linear mechanical freedom and horizontal longitudinal linear mechanical freedom, the direction of the horizontal transverse linear mechanical freedom is parallel to the opening direction of the gap, and the connection direction from the slide supply assembly to the microscope assembly is parallel to the direction of the horizontal longitudinal linear mechanical freedom.
4. The automatic microscope detection system according to claim 1, characterized in that: The slide glass supply assembly comprises a slide glass box, in which a plurality of slide glasses are stacked vertically in a stacking manner, and the bottom of the slide glass box is provided with an opening.
5. The automatic microscope detection system according to claim 1, characterized in that: The outer wall of the dropper assembly in the sample dropper assembly is equipped with a steering gear assembly and a peristaltic pump, the steering gear assembly can drive one end of the dropper assembly to move, and the steering gear assembly has a swinging mechanical freedom around a vertical line in space; The sample drop assembly also includes a sample container, and the peristaltic pump enables one end of the dropper assembly to draw the sample from the sample container; An electric push rod assembly is in contact with the lower side of the sample container, and the electric push rod assembly drives the sample container to move. The sample container has a vertical lifting mechanical degree of freedom.
6. The automatic microscope detection system according to claim 1, characterized in that: The cover glass supply assembly includes a cover glass box, in which a plurality of cover glasses are stacked vertically in a stacking manner, and the bottom of the cover glass box is provided with an opening; The cover glass supply assembly comprises a cover glass push plate, which has a horizontal reciprocating translation mechanical freedom, and the cover glass push plate can push out the cover glass located at the bottom of the cover glass box.
7. The automatic microscope detection system according to claim 6, characterized in that: The cover glass supply assembly includes a stepping motor, and the stepping motor is hinged with one end of the cover glass push plate through a rotating rod; The upper surface of the cover glass seat is provided with an oblique linear groove capable of guiding the cover glass, and the height of the linear groove gradually decreases in a direction away from the cover glass box.
8. The automatic microscope detection system according to claim 1, characterized in that: A stage assembly is also provided below the transfer and loading plug plate, and the upper surface of the stage assembly can support a glass slide and / or a glass slide sample; The stage assembly is provided with a vertically penetrating liquid leakage hole.
9. The automatic microscope detection system according to claim 8, characterized in that: A light source assembly is provided below the stage assembly, and the light source assembly is located directly below the microscope assembly. The stage assembly includes a light leakage hole for light from the light source assembly to pass through.
10. The automatic microscope detection system according to claim 8, characterized in that: A waste collection assembly is also provided below the stage assembly, and the waste collection assembly includes a collection trough and a collection bucket; The collecting tank is located directly below the liquid leakage hole; a collecting bucket is arranged below the outer side of one end of the stage assembly adjacent to the microscope assembly.