Multi-joint detection reagent strip

Abstract

The utility model belongs to the field of reagent strips, and provides a multi-joint detection reagent strip which comprises a reagent strip main body, the handle is arranged at one end of the reagent strip main body; the sample hole, the first device hole, the at least two second device holes, the special liquid area and the public liquid area are formed in the reagent strip main body and sequentially distributed from the handle to the other end of the reagent strip main body, a tip is arranged in the first device hole, a disposable magnetic separation sleeve is arranged in each second device hole, and the special liquid area and the public liquid area are covered with sealing films; the special liquid area comprises at least two first reagent holes and at least two second reagent holes, the at least two first reagent holes are respectively used for accommodating different magnetic particle labeled ligands, and the at least two second reagent holes are respectively used for accommodating different enzyme labeled ligands; the public liquid area comprises at least two third reagent holes and at least two fourth reagent holes, the third reagent holes are used for containing cleaning liquid, and the fourth reagent holes are used for containing luminous substrate liquid. The multi-joint inspection device can meet the multi-joint inspection requirement of equipment.

Description

Technical Field

[0001] The utility model belongs to the technical field of reagent strips, and particularly relates to a multi - joint detection reagent strip. Background Art

[0002] As a rapidly developing non - radioactive immunoassay technology, chemiluminescence immunoassay technology has become one of the important directions in immunological detection. Its principle is to directly measure the immune reaction using chemiluminescence signals. Chemiluminescence devices applying chemiluminescence immunoassay technology have advantages such as high sensitivity, good repeatability, high accuracy, good specificity, and wide linear range.

[0003] POCT (Point - Of - Care Testing) is a detection method that conducts clinical tests immediately at the sampling site, omitting the complex processing procedures of specimens in the laboratory, and thus quickly obtaining test results. It has the characteristics of simple instrument preparation, easy operation, and rapid reporting of results.

[0004] Currently, by applying chemiluminescence immunoassay technology to POCT products, POCT fully automatic chemiluminescence devices have been manufactured. The POCT fully automatic chemiluminescence devices generally include a reaction chamber module. The reaction chamber module is loaded with reagent strips that seal various reagents, and the reagent strips are moved to other modules for corresponding processing.

[0005] However, the reagent strips currently used in POCT fully automatic chemiluminescence devices are often used for the detection of a single biomarker. When multiple biomarker joint detections are required, simply directly increasing the reagent holes on the reagent strip will significantly increase the length of the reagent strip, and thus significantly increase the volume of the supporting equipment, unable to meet the requirements of miniaturization and portability of POCT devices. Summary of the Utility Model

[0006] An embodiment of the utility model provides a multi - joint detection reagent strip, aiming to solve the technical problem that the reagent strips currently used in POCT fully automatic chemiluminescence devices cannot meet the requirements of multi - joint detection.

[0007] An embodiment of the utility model is implemented as follows. A multi - joint detection reagent strip is used for a multi - channel multi - joint detection POCT fully automatic chemiluminescence device. The multi - joint detection reagent strip includes:

[0008] A reagent strip main body;

[0009] A handle provided at one end of the reagent strip main body; and

[0010] A sample well, a first device well, at least two second device wells, a dedicated liquid area and a common liquid area arranged in sequence from the handle to the other end of the reagent strip body on the reagent strip body. A tip head is provided in the first device well, and a disposable magnetic separation sleeve is provided in the second device well. The dedicated liquid area and the common liquid area are covered with a sealing film;

[0011] Among them, the dedicated liquid area includes at least two first reagent holes and at least two second reagent holes. At least two of the first reagent holes are respectively used to accommodate different magnetic particle-labeled ligands, and at least two of the second reagent holes are respectively used to accommodate different enzyme-labeled ligands; the common liquid area includes at least two third reagent holes and at least two fourth reagent holes. The third reagent hole is used to accommodate a cleaning solution, and the fourth reagent hole is used to accommodate a luminescent substrate solution.

[0012] Furthermore, the number of the second device wells, the number of the first reagent holes, the number of the second reagent holes and the number of the fourth reagent holes are the same, and the number of the third reagent holes is at least twice the number of the fourth reagent holes.

[0013] Furthermore, at least two of the first reagent holes are adjacent to each other, and at least two of the second reagent holes are adjacent to each other;

[0014] At least two of the third reagent holes are adjacent to each other, and at least two of the fourth reagent holes are adjacent to each other.

[0015] Furthermore, the number of the second device wells is 3, the number of the first reagent holes is 3, the number of the second reagent holes is 3, the number of the third reagent holes is 6, and the number of the fourth reagent holes is 3.

[0016] Furthermore, at least two of the first reagent holes and at least two of the second reagent holes are arranged in an interlaced manner, and at least two of the third reagent holes and at least two of the fourth reagent holes are arranged in an interlaced manner.

[0017] Furthermore, a plurality of uniformly distributed limiting protrusions are provided at the bottom of the hole wall of the first device well, and the size of the space surrounded by the plurality of limiting protrusions in the first device well is smaller than the size of the bottom end of the disposable magnetic separation sleeve.

[0018] Furthermore, the tip head includes a sharp end and a main body section connected to the sharp end. A perforation is provided on the sharp end, and the sharp end is used to break the sealing film. The size of the bottom end of the disposable magnetic separation sleeve is smaller than the size of the connection part between the sharp end and the main body section.

[0019] Furthermore, the surface of the handle is provided with anti-slip patterns.

[0020] Furthermore, the reagent strip main body, the handle, the sample hole, the first device hole, the second device hole, the dedicated liquid area and the common liquid area are integrally injection molded.

[0021] Furthermore, the shape of the multi-assay reagent strip is adapted to the shape of the accommodating groove in the reaction chamber.

[0022] In the multi-assay reagent strip of the embodiment of the present utility model, at least two second device holes are used to place at least two disposable magnetic separation sleeves. A dedicated liquid area and a common liquid area are designed on the reagent strip main body adjacent to the second device holes. Among them, the dedicated liquid area includes at least two first reagent holes for respectively accommodating different magnetic particle-labeled ligands and at least two second reagent holes for respectively accommodating different enzyme-labeled ligands, that is, the dedicated liquid area can react with the sample to obtain at least two markers, and cooperate with at least two disposable magnetic separation sleeves to transfer at least two markers through magnetic particles. The common liquid area includes at least two third reagent holes for accommodating cleaning liquid and at least two fourth reagent holes for accommodating luminescent substrate liquid. Immediately afterwards, at least two markers can be cleaned and two corresponding chemiluminescent reactions can occur, finally realizing the detection and analysis of at least two items. The whole processing process of the sample on the multi-assay reagent strip is continuous, compact and efficient. Through the above targeted design of the multi-assay reagent strip to meet the multi-assay requirements, the supporting equipment end can also maintain a compact and relatively small structure. Description of the Drawings

[0023] Figure 1 is a three-dimensional schematic diagram of the multi-assay reagent strip of the embodiment of the present utility model;

[0024] Figure 2 is a structural schematic diagram of the multi-assay reagent strip of the embodiment of the present utility model;

[0025] Figure 3 is a cross-sectional schematic diagram of the multi-assay reagent strip of the embodiment of the present utility model.

[0026] Main Element Symbol Description:

[0027] Multi-assay reagent strip - 10; Reagent strip main body - 11; Handle - 12; Sample hole - 13; First device hole - 14; Limit protrusion - 141; Second device hole - 15; Dedicated liquid area - 16; First reagent hole - 161; Second reagent hole - 162; Common liquid area - 17; Third reagent hole - 171; Fourth reagent hole - 172; Tip head - 18; Sharp end - 181; Main body section - 182; Disposable magnetic separation sleeve - 19. Detailed Embodiments

[0028] In order to make the objectives, technical solutions and advantages of the present utility model more clearly understood, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the accompanying drawings are exemplary and are only used to explain the present utility model and should not be construed as a limitation to the present utility model. In addition, it should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0029] In the description of the present utility model, it should be understood that the orientation or positional relationship indicated in the description of the orientation and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation to the present utility model.

[0030] In addition, the terms "first" and "second" are only used for descriptive purposes and should not be construed as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of the said features. In the description of the present utility model, "a plurality of" means two or more, unless otherwise specifically defined.

[0031] The following disclosure provides many different embodiments or examples for implementing different structures of the present utility model. To simplify the disclosure of the present utility model, the components and settings of specific examples are described below. Of course, they are only examples and are not intended to limit the present utility model. In addition, the present utility model may repeat reference numerals and / or reference letters in different examples, and this repetition is for the purpose of simplification and clarity and does not itself indicate the relationship between the various embodiments and / or settings discussed. In addition, the present utility model provides examples of various specific processes and materials, but those of ordinary skill in the art may be aware of the application of other processes and / or the use of other materials.

[0032] The multiplex detection reagent strip 10 of the embodiment of the present utility model is used for a multi-channel multiplex detection POCT fully automatic chemiluminescence device. Please refer to Figures 1 to 3 , the multiplex detection reagent strip 10 includes:

[0033] A reagent strip main body 11;

[0034] A handle 12 provided at one end of the reagent strip main body 11; and

[0035] A sample hole 13, a first device hole 14, at least two second device holes 15, a dedicated liquid area 16 and a common liquid area 17 that are arranged in sequence on the reagent strip main body 11 from the handle 12 to the other end of the reagent strip main body 11. A tip head 18 is provided in the first device hole 14, and a disposable magnetic separation sleeve 19 is provided in the second device hole 15. The dedicated liquid area 16 and the common liquid area 17 are covered with a sealing film;

[0036] Among them, the dedicated liquid area 16 includes at least two first reagent holes 161 and at least two second reagent holes 162. The at least two first reagent holes 161 are respectively used to accommodate different magnetic particle-labeled ligands, and the at least two second reagent holes 162 are respectively used to accommodate different enzyme-labeled ligands; the common liquid area 17 includes at least two third reagent holes 171 and at least two fourth reagent holes 172. The third reagent holes 171 are used to accommodate a cleaning solution, and the fourth reagent holes 172 are used to accommodate a luminescent substrate solution.

[0037] In the multiplex detection reagent strip 10 of the embodiment of the present utility model, at least two second device holes 15 are used to place at least two disposable magnetic separation sleeves 19. A dedicated liquid area 16 and a common liquid area 17 are designed on the reagent strip main body 11 adjacent to the second device holes 15. Among them, the dedicated liquid area 16 includes at least two first reagent holes 161 for respectively accommodating different magnetic particle-labeled ligands and at least two second reagent holes 162 for respectively accommodating different enzyme-labeled ligands. That is, the dedicated liquid area 16 can react with the sample to obtain at least two marker reaction complexes, and cooperate with at least two disposable magnetic separation sleeves 19 to transfer at least two marker reaction complexes through magnetic particles. The common liquid area 17 includes at least two third reagent holes 171 for accommodating a cleaning solution and at least two fourth reagent holes 172 for accommodating a luminescent substrate solution. Immediately afterwards, at least two marker reaction complexes can be cleaned and two corresponding chemiluminescent reactions can occur, finally realizing the detection and analysis of at least two items. The entire processing process of the sample on the multiplex detection reagent strip 10 is continuous, compact and efficient. By making the above targeted design for the multiplex reagent strip 10 to meet the multiplex detection requirements, the supporting equipment end can also maintain a compact and relatively small structure.

[0038] Exemplarily, a multi-channel multiplex POCT fully automatic chemiluminescence device may include a reaction chamber assembly, a multi-channel multiplex parallel pretreatment device located relatively above the reaction chamber assembly, and a PMT assembly located at the rear end of the multi-channel multiplex parallel pretreatment device. The reaction chamber assembly is used to load the multiplex reagent strip 10 and reciprocate along the length direction of the device. In the multi-channel multiplex parallel pretreatment device, there are magnetic rods for transferring magnetic microparticles. To achieve multiplex detection, the magnetic rods can be at least two rows. The multi-channel multiplex parallel pretreatment device can load tip heads 18 to aspirate and discharge samples, and load disposable magnetic separation sleeves 19 to cooperate with the magnetic rods to transfer magnetic microparticles. The PMT assembly can be used to detect the luminescence value of the detection position (i.e., the above-mentioned fourth reagent hole 172) of the multiplex reagent strip 10.

[0039] The reagent strip body 11 is generally strip-shaped, and a handle 12 can be provided at one end thereof. Anti-slip patterns can be provided on the handle 12 to increase the friction between the multiplex reagent strip 10 and the operator's fingers, facilitating the operator to hold it firmly. After encapsulating the corresponding reagents in the corresponding holes, the surface of the multiplex reagent strip 10 can be heat-sealed with a film to prevent the reagents in each hole from volatilizing, leaking, or being contaminated, and also facilitate the storage and transportation of the multiplex reagent strip 10. The multiplex reagent strip 10 is a disposable consumable and can be directly discarded and destroyed after use.

[0040] Samples such as serum or whole blood can be added to the sample hole. The tip head 18 is a hollow structure with a sharp end, and a perforation is provided on the end, enabling the tip head 18 to be used for transferring samples or reagents, and also for breaking the sealing film on each hole. The disposable magnetic separation sleeve 19 is also a hollow structure and can be combined with the magnetic rod to adsorb, mix, wash, and transfer magnetic microparticles. The third reagent hole can be used to wash the magnetic microparticles. The fourth reagent hole is used for chemiluminescence reaction and supplying the PMT assembly to read the luminescence value.

[0041] In one embodiment, the hole shapes of the first device hole 14 and the second device hole 15 can be round holes, and the hole shapes of the sample hole 13, the first reagent hole 161, the second reagent hole 162, the third reagent hole 171, and the fourth reagent hole 172 can be square holes, rectangular holes, waist holes, etc.

[0042] In this embodiment, the first reagent hole 161 (or understood as the magnetic-labeled ligand hole) and the second reagent hole 162 (or understood as the enzyme-labeled ligand hole) form a dedicated liquid area 16, including at least two different magnetic-labeled ligands and at least two different enzyme-labeled ligands, where the ligands include but are not limited to haptens, antigens, monoclonal antibodies, polyclonal antibodies, and nucleic acid ligands. The third reagent hole 171 (or understood as the washing solution hole) and the fourth reagent hole 172 (or understood as the luminescence substrate hole) form a common liquid area 17. The dedicated liquid area 16 and the common liquid area 17 form a liquid sealing area, which can include the same washing solution and the same luminescence substrate solution.

[0043] Among them, the dedicated liquid area 16 can be understood as components directly related to the detection items (such as magnetic bead-labeled ligands, enzyme-labeled ligands, and pretreatment solutions, etc.), and the common liquid area 17 can be understood as components that can be shared among detection items (such as cleaning solutions and luminescent solutions, etc.). In the common liquid area 17, even if there is a slight mixing of the liquids in adjacent wells, it will not have an obvious impact on the detection results.

[0044] Please refer to Figures 1 to 3 , furthermore, the number of the second device holes 15, the number of the first reagent holes 161, the number of the second reagent holes 162, and the number of the fourth reagent holes 172 are the same, and the number of the third reagent holes 171 is at least twice the number of the fourth reagent holes 172 to achieve a complete set of full-process operations.

[0045] Moreover, the number of the second device holes 15, the first reagent holes 161, the second reagent holes 162, and the fourth reagent holes 172 in this embodiment is equal to the number of rows of the magnetic rods provided in the multi-channel multi-assay POCT fully automatic chemiluminescence device.

[0046] The number of the second device holes 15 is the number of the disposable magnetic separation sleeves 19. By using the magnetic rods with a set number of rows to combine with the corresponding number of disposable magnetic separation sleeves 19, the magnetic microparticles in the corresponding number of the first reagent holes 161 are transferred, and react with the enzyme-labeled ligands in the corresponding number of the second reagent holes 162, and corresponding cleaning operations are performed in the corresponding number of the third reagent holes 171, and finally corresponding chemiluminescence reactions are performed in the corresponding number of the fourth reagent holes 172 to achieve the detection of the corresponding number of items.

[0047] Please refer to Figures 1 to 3 , furthermore, at least two first reagent holes 161 are adjacent to each other, at least two second reagent holes 162 are adjacent to each other, at least two third reagent holes 171 are adjacent to each other, and at least two fourth reagent holes 172 are adjacent to each other.

[0048] In this way, the magnetic rods in the multi-channel multi-assay parallel pre-treatment device can also be arranged adjacent to each other in rows. For example, if there are at least two rows of magnetic rods, at least two disposable magnetic separation sleeves 19 can be loaded simultaneously corresponding to at least two rows of magnetic rods, so as to simultaneously achieve relevant reactions in at least two first reagent holes 161 and at least two second reagent holes 162, simultaneously perform cleaning operations in at least two third reagent holes 171, and finally simultaneously achieve chemiluminescence reactions in at least two fourth reagent holes 172, ensuring the analysis efficiency of the device while realizing multi-assay.

[0049] Exemplarily, taking two first reagent holes 161, two second reagent holes 162, two third reagent holes 171 and four fourth reagent holes 172 as an example, the arrangement of the above on the reagent strip main body 11 can be:

[0050] The first reagent holes 161, the first reagent holes 161, the second reagent holes 162, the second reagent holes 162, or the second reagent holes 162, the second reagent holes 162, the first reagent holes 161, the first reagent holes 161, etc.; the third reagent holes 171, the third reagent holes 171, the fourth reagent holes 172, the fourth reagent holes 172, or the fourth reagent holes 172, the fourth reagent holes 172, the third reagent holes 171, the third reagent holes 171, etc.

[0051] Without enumerating the adjacent arrangement ways of the first reagent holes 161, the second reagent holes 162, the third reagent holes 171 and the fourth reagent holes 172 here, the above can be arranged in an interspersed manner according to specific requirements.

[0052] Please refer to Figures 1 to 3 , further, there are 3 second device holes 15, 3 first reagent holes 161, 3 second reagent holes 162, 6 third reagent holes 171, and 3 fourth reagent holes 172.

[0053] That is to say, on the multi - analyte detection reagent strip 10 of this embodiment, there are 3 disposable magnetic separation sleeves 19, 3 (different) magnetic - labeled ligands, 3 (different) enzyme - labeled ligands, 6 cleaning solutions and 3 chemiluminescent substrate solutions. The supporting multi - channel multi - analyte detection POCT fully automatic chemiluminescence device can simultaneously load 3 disposable magnetic separation sleeves 19 on a single multi - analyte detection reagent strip 10 to simultaneously transfer the magnetic particles in 3 reagent holes, perform 2 cleanings, simultaneously perform 3 chemiluminescent reactions, and finally realize the detection of three items, meeting the multi - analyte detection requirements of the device.

[0054] Further, at least two first reagent holes 161 and at least two second reagent holes 162 are arranged in an interspersed manner, and at least two third reagent holes 171 and at least two fourth reagent holes 172 are arranged in an interspersed manner to meet the requirements of specific operation timing.

[0055] Exemplarily, taking two first reagent holes 161, two second reagent holes 162, two third reagent holes 171 and four fourth reagent holes 172 as an example, the arrangement of the above on the reagent strip main body 11 can be:

[0056] The first reagent well 161, the second reagent well 162, the first reagent well 161, the second reagent well 162, or the second reagent well 162, the first reagent well 161, the second reagent well 162, the first reagent well 161, etc. are arranged; and the third reagent well 171, the fourth reagent well 172, the fourth reagent well 172, the third reagent well 171, the fourth reagent well 172, the fourth reagent well 172, or the fourth reagent well 172, the fourth reagent well 172, the third reagent well 171, the fourth reagent well 172, the fourth reagent well 172, the third reagent well 171, or the fourth reagent well 172, the third reagent well 171, the fourth reagent well 172, the fourth reagent well 172, the third reagent well 171, the fourth reagent well 172, etc. are arranged.

[0057] The arrangement ways of the interspersed first reagent well 161, second reagent well 162, third reagent well 171 and fourth reagent well 172 are not enumerated here. According to specific requirements, the above-mentioned ones can be interspersed and arranged.

[0058] Please refer to Figure 2 , further, a plurality of uniformly distributed limiting protrusions 141 are provided at the bottom of the pore wall of the first device hole 14, and the size of the space surrounded by the plurality of limiting protrusions 141 in the first device hole 14 is smaller than the size of the bottom end of the disposable magnetic separation sleeve 19.

[0059] To avoid misplacing the disposable magnetic separation sleeve 19 into the first device hole 14, in this embodiment, a plurality of limiting protrusions 141 are provided at the bottom of the pore wall of the first device hole 14. The setting of the plurality of limiting protrusions 141 can prevent the disposable magnetic separation sleeve 19 from being placed in the first device hole 14. If the disposable magnetic separation sleeve 19 is misplaced into the first device hole 14, it will be higher than the first device hole 14 and will generate vibration feedback. At this time, the misoperation can be determined by detecting the height of the device in the first device hole 14 or through vibration feedback, and the wrongly placed disposable magnetic separation sleeve 19 can be loaded back into the correct second device hole 15 to ensure that the disposable magnetic separation sleeve 19 is correctly retracted.

[0060] Please refer to Figure 3 , further, the tip 18 includes a sharp end 181 and a main body section 182 connected to the sharp end 181. A perforation is provided at the end of the sharp end 181. The sharp end 181 is used to break the sealing film, and the size of the bottom end of the disposable magnetic separation sleeve 19 is smaller than the size of the connection part between the sharp end 181 and the main body section 182.

[0061] Specifically, the top opening of the main body section 182 can be in interference fit with a loading structure (such as a loading head), so that the tip 18 can be driven to move by the loading structure (equipment) to perform operations such as film breaking and sample aspiration and ejection through the sharp end 181.

[0062] Due to factors such as manufacturing tolerances and operation errors, when the tip 18 breaks the sealing film at the opening position, the position of the opening formed by the break may not be located in the middle part of the hole position, or the size of the opening formed may not be large. In this embodiment, the size of the bottom end of the disposable magnetic separation sleeve 19 is designed to be smaller than the size of the connecting part between the sharp end 181 and the main body section 182, so that the size of the opening formed by the tip 18 breaking the film can be larger than the disposable magnetic separation sleeve 19. The disposable magnetic separation sleeve 19 can relatively accurately correspond to the opening formed by the tip 18 breaking the film, and can more smoothly extend into the reagent hole. When transferring magnetic particles, it can avoid the magnetic particles adsorbed on the outer wall of the disposable magnetic separation sleeve 19 from being scraped off by the sealing film, ensuring the normal progress of the detection.

[0063] Furthermore, the reagent strip body 11, the handle 12, the sample hole 13, the first device hole 14, the second device hole 15, the dedicated liquid area 16 and the common liquid area 17 are integrally injection-molded, and the formed multi-assay reagent strip 10 has better integrity, which can improve the structural strength, simplify the production process and control the production cost.

[0064] Please refer to Figures 1 to 3 , furthermore, the shape of the multi-assay reagent strip 10 is adapted to the shape of the receiving groove in the reaction chamber.

[0065] Specifically, the outer wall of the multi-assay reagent strip 10 fits with the inner wall of the receiving groove in the reaction chamber, which can not only ensure the stability of the multi-assay reagent strip 10 on the reaction chamber, to ensure the stability of the multi-assay reagent strip 10 during movement, and avoid the leakage of reagents and samples. There is a heating module in the reaction chamber, which can comprehensively keep the multi-assay reagent strip 10 warm and heated through the receiving groove, meeting the temperature conditions for chemiluminescence determination of samples and reagents.

[0066] In the description of this specification, the descriptions referring to terms such as "Embodiment 1", "Embodiment 2", etc. mean that the specific features, structures, materials or characteristics described in connection with the implementation manners or examples are included in at least one implementation manner or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same implementation manner or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more implementation manners or examples.

[0067] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A multi-test reagent strip for a multi-channel multi-test POCT fully automatic chemiluminescence device, characterized in that: The multiple test reagent strip comprises: a reagent strip body; a handle disposed at one end of the test strip body; and A sample hole, a first device hole, at least two second device holes, a dedicated liquid area and a common liquid area are arranged on the reagent strip body in sequence from the handle to the other end of the reagent strip body, a tip is provided in the first device hole, a disposable magnetic separation sleeve is provided in the second device hole, and the dedicated liquid area and the common liquid area are covered with a sealing film; Among them, the dedicated liquid area includes at least two first reagent holes and at least two second reagent holes, at least two of the first reagent holes are used to accommodate different magnetic particle labeled ligands, and at least two of the second reagent holes are used to accommodate different enzyme labeled ligands; the common liquid area includes at least two third reagent holes and at least two fourth reagent holes, the third reagent holes are used to accommodate cleaning liquid, and the fourth reagent holes are used to accommodate luminescent substrate liquid.

2. The multiple test reagent strip according to claim 1, characterized in that: The number of the second device holes, the number of the first reagent holes, the number of the second reagent holes and the number of the fourth reagent holes are the same, and the number of the third reagent holes is at least twice the number of the fourth reagent holes.

3. The multiple test reagent strip according to claim 2, characterized in that: At least two of the first reagent wells are disposed adjacent to each other, and at least two of the second reagent wells are disposed adjacent to each other; At least two of the third reagent holes are arranged adjacent to each other, and at least two of the fourth reagent holes are arranged adjacent to each other.

4. The multiple test reagent strip according to claim 3, characterized in that: The number of the second device holes is 3, the number of the first reagent holes is 3, the number of the second reagent holes is 3, the number of the third reagent holes is 6, and the number of the fourth reagent holes is 3.

5. The multiple test reagent strip according to claim 2, characterized in that: The at least two first reagent holes and the at least two second reagent holes are interlaced, and the at least two third reagent holes and the at least two fourth reagent holes are interlaced.

6. The multiple test reagent strip according to claim 1, characterized in that: The bottom of the hole wall of the first device hole is provided with a plurality of evenly distributed limiting protrusions, and the size of the space enclosed by the plurality of limiting protrusions in the first device hole is smaller than the size of the bottom end of the disposable magnetic separation sleeve.

7. The multiple test reagent strip according to claim 1, characterized in that: The tip head includes a sharp end and a main body section connected to the sharp end, the sharp end is provided with a perforation, and the sharp end is used to break the sealing film, and the size of the bottom end of the disposable magnetic separation sleeve is smaller than the size of the connecting part between the sharp end and the main body section.

8. The multiple test reagent strip according to claim 1, characterized in that: The surface of the handle is provided with anti-skid patterns.

9. The multiple test reagent strip according to claim 1, characterized in that: The reagent strip body, the handle, the sample hole, the first device hole, the second device hole, the dedicated liquid area and the common liquid area are integrally injection-molded.

10. The multiple test reagent strip according to claim 1, characterized in that: The shape of the multiple test reagent strip is adapted to the shape of the accommodating groove in the reaction chamber.

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