Multifunctional jacket for assisting freeze-drying
By designing a multifunctional jacket for lyophilization, the addition of dry ice in the inner liner chamber delays sample melting, and prevents photodecomposition through light-proof materials, the problems of rapid sample melting and photosensitive compounds degradation in lyophilization experiments are solved, achieving higher lyophilization success rate and sample protection effect.
Patent Information
- Application Number
- CN202422221196.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-10
- Publication Date
- 2025-06-03
- Estimated Expiration
- 2034-09-10
AI Technical Summary
In lyophilization experiments, samples that were successfully prefreeze may melt rapidly when transferred to the lyophilization machine, and the photosensitive compounds are susceptible to light degradation during lyophilization.
A multi-function jacket is designed, with the inner liner equipped with a chamber for placing a freeze-dried bottle, and dry ice is added multiple times in the inner liner chamber through the pipeline to delay sample melting. At the same time, the jacketed shell and inner liner are made of light-proof materials to prevent light decomposition.
It effectively delays the rapid melting of prefrozen samples during the lyophilization process, improves the success rate of lyophilization, and prevents the light degradation of photosensitive compounds.
Smart Images
Figure CN222930849U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of jackets, and particularly relates to a multifunctional jacket for assisting freeze-drying. Background Art
[0002] In the research process of small molecule chemical raw drugs, the amorphous state is an important research field in the research of small molecule solid drugs. The formation of amorphous helps to improve the solubility of small molecule chemical drugs and is an inescapable research content in solid state research. Therefore, in drug research, there is a need to prepare crystalline raw drugs into corresponding amorphous forms. Currently, the commonly used preparation methods for amorphous drugs mainly include rotary evaporation, freeze-drying, grinding, spray drying, etc. Among them, the freeze-drying process has the advantages of high repeatability, good sample uniformity, and simple operation. Therefore, the freeze-drying process is a commonly used method for preparing amorphous drugs.
[0003] Due to the emergence of lipophilic targeted drugs, a considerable part of organic small molecule compounds have poor solubility in water (i.e., poorly soluble compounds). When conducting freeze-drying experiments, it is first necessary to dissolve the compound in a certain amount of solvent. Therefore, selecting a suitable solvent for freeze-drying is the first problem to be considered; due to the poor solubility of poorly soluble compounds, the range of solvent selection is narrow and pure water cannot be used. Generally, only a few solvents can be used for the freeze-drying process. When the selection of available solvents is relatively small, it may not be possible to ensure that the solvent has a relatively high melting point. When using these solvents and conducting freeze-drying experiments with an external freeze-dryer, pre-freezing may become a problem.
[0004] When conducting freeze-drying experiments, after the compound is fully dissolved, currently, liquid nitrogen or dry ice ethanol bath is generally used for pre-freezing the raw drug. When the solution dissolving the raw drug is frozen into a solid and an external freeze-dryer is used for freeze-drying, even if the sample is successfully pre-frozen in the liquid nitrogen or dry ice ethanol bath and maintains a good solid form, due to the low melting point of the solvent, just after leaving the low-temperature environment and having a short contact with the outside world, there may be a phenomenon of partial melting or even complete melting, which affects the results of the freeze-drying experiment and leads to the failure of the freeze-drying experiment.
[0005] In addition, when using an external freeze-dryer, the glass vial has light transmittance, which may cause the sample to decompose under light. Therefore, it is also necessary to use a convenient device for light shielding. Summary of the Utility Model
[0006] The technical problem to be solved by the present utility model is that under the existing experimental conditions, when freeze-drying experiments are carried out on raw material drug compounds, there are problems such as the successfully pre-frozen samples rapidly melting within a short time after being transferred to the freeze-dryer, and the photo-degradation of photosensitive compounds during the freeze-drying experiment. The present utility model provides a multi-functional jacket for assisting freeze-drying. By adding a jacket for placing the freeze-drying bottle inside the outer shell to keep the freeze-drying bottle warm, and through the additional pipeline, dry ice can be replenished multiple times in the chamber of the inner container, thereby delaying the rapid melting of the successfully pre-frozen samples after the start of freeze-drying. This jacket is not completely airtight. During the freeze-drying process, the added dry ice can slowly sublimate. While ensuring a relatively low initial temperature, the slow sublimation of dry ice causes the internal temperature to rise gently, thereby realizing the freeze-drying of the samples. The structure is simple and easy to use, to solve the defects caused by the prior art.
[0007] To solve the above technical problems, the present utility model provides the following technical solutions:
[0008] A multi-functional jacket for assisting freeze-drying, which includes a housing. An opening for the external tube to pass through is provided at the top of the housing, and a locking member matching the external tube is arranged at the opening at the top of the housing. A hinge is installed at the bottom of the housing;
[0009] An inner container is installed inside the housing. A chamber for placing the freeze-drying bottle is provided inside the inner container, which can be suitable for freeze-drying bottles of different specifications and sizes. A pipeline communicating with the chamber is installed on the housing. There is a certain space between the inner container and the freeze-drying bottle. Dry ice can be replenished in time through the pipeline to delay the rapid melting of the successfully pre-frozen samples after they are taken out of the low-temperature environment;
[0010] A valve connected to the top of the freeze-drying bottle is installed at the bottom of the external tube.
[0011] In the above multi-functional jacket for assisting freeze-drying, a visual window is installed at the same position of the housing and the inner container, and the state of the sample can be observed through the visual window.
[0012] In the above multi-functional jacket for assisting freeze-drying, the inner container is in the shape of an open beaker.
[0013] In the above multi-functional jacket for assisting freeze-drying, the inner container is a low-temperature resistant inner container.
[0014] In the above multi-functional jacket for assisting freeze-drying, the inner container is made of polyethylene or polypropylene or polytetrafluoroethylene.
[0015] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein light-shielding materials are added during the production of the housing and the inner liner, which is applicable to the freeze-drying of photosensitive compounds and can avoid the phenomenon of photolysis during the freeze-drying process.
[0016] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein the locking member is a snap fastener, and a snap ring matching the snap fastener is provided on the external hanging tube. After the freeze-drying bottle is placed into the jacket, the jacket is effectively fixed outside the freeze-dryer through the snap fastener to prevent movement, and the snap fastener is connected to the external hanging tube on the freeze-dryer.
[0017] According to the technical solution provided by the above-mentioned multifunctional jacket for assisting freeze-drying of the present invention, the following technical effects are achieved:
[0018] By adding a jacket for placing the freeze-drying bottle inside the outer shell to keep the freeze-drying bottle warm, and through the additional pipeline, dry ice can be replenished multiple times in the chamber of the inner liner. Furthermore, the rapid melting phenomenon of the successfully pre-frozen sample after the start of freeze-drying can be delayed. This jacket is not completely sealed. During the freeze-drying process, the added dry ice can slowly sublimate. While ensuring a relatively low initial temperature, the slow sublimation of dry ice makes the internal temperature rise smoothly, thereby realizing the freeze-drying of the sample. The structure is simple and convenient to use. Description of the Drawings
[0019] Figure 1 It is a schematic structural diagram of a multifunctional jacket for assisting freeze-drying of the present invention.
[0020] Among them, the reference numerals are as follows:
[0021] Jacket 100, housing 101, locking member 102, hinge 103, inner liner 104, chamber 105, pipeline 106, visual window 107, freeze-drying bottle 200, external hanging tube 201, valve 202. Detailed Embodiments
[0022] In order to make the technical means, creative features, achieved purposes and functions of the present invention easy to understand, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the specific drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.
[0023] All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts shall fall within the protection scope of the present invention.
[0024] It should be noted that the structures, proportions, sizes, etc. shown in the drawings of this specification are only used to cooperate with the content disclosed in the specification for those familiar with this technology to understand and read, and are not used to limit the implementation conditions of the present utility model. Therefore, they do not have substantial technical significance. Any modification of the structure, change of the proportional relationship, or adjustment of the size, without affecting the effects that the present utility model can produce and the purposes that can be achieved, should still fall within the scope covered by the technical content disclosed in the present utility model.
[0025] At the same time, the terms such as "upper", "lower", "left", "right", "middle", and "one" cited in this specification are only for the convenience of clear narration and are not used to limit the scope of implementation of the present utility model. The change or adjustment of their relative relationships, without substantial change in the technical content, should also be regarded as the scope within which the present utility model can be implemented.
[0026] A preferred embodiment of the present utility model provides a multi-functional jacket for assisting freeze-drying. The purpose is to add a jacket for placing a freeze-drying bottle inside the outer shell to keep the freeze-drying bottle warm. Through the additional pipeline, dry ice can be replenished multiple times in the chamber of the inner liner, thereby delaying the rapid melting phenomenon of the pre-frozen successful sample after the start of freeze-drying. This jacket is not completely sealed. During the freeze-drying process, the added dry ice can slowly sublimate. While ensuring a relatively low initial temperature, the slow sublimation of dry ice makes the internal temperature rise gently, thus realizing the freeze-drying of the sample. The structure is simple and convenient to use.
[0027] As Figure 1 shown, a multi-functional jacket for assisting freeze-drying, which includes a housing 101. An opening for the external tube 201 to pass through is provided at the top of the housing 101. A locking member 102 matching the external tube 201 is provided at the opening at the top of the housing 101. A hinge 103 is installed at the bottom of the housing 101;
[0028] An inner liner 104 is installed inside the housing 101. A chamber 105 for placing a freeze-drying bottle 200 is provided inside the inner liner 104, which can be applicable to freeze-drying bottles 200 of different specifications and sizes. A pipeline 106 communicating with the chamber 105 is installed on the housing 101. There is a certain space between the inner liner 104 and the freeze-drying bottle 200. Through the pipeline 106, dry ice can be replenished in time to delay the rapid melting of the pre-frozen successful sample after it leaves the low-temperature environment;
[0029] A valve 202 connected to the top of the freeze-drying bottle 200 is installed at the bottom of the external tube 201.
[0030] In the above-mentioned multi-functional jacket for assisting freeze-drying, a visual window 107 is installed at the same position on the housing 101 and the inner liner 104, and the state of the sample can be observed through the visual window 107.
[0031] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein the inner container 104 is in the shape of an open beaker.
[0032] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein the inner container 104 is a low-temperature resistant inner container 104, and the housing 101 is made of organic materials or composite materials.
[0033] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein the inner container 104 is made of polyethylene or polypropylene or polytetrafluoroethylene, and the housing 101 is made of ceramic or alloy or heat-insulating and light-shielding glass.
[0034] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein light-shielding materials are added during the production of the housing 101 and the inner container 104, which is suitable for the freeze-drying of photosensitive compounds. It can avoid problems such as degradation caused by light.
[0035] The above-mentioned multifunctional jacket for assisting freeze-drying, wherein the locking member 102 is a buckle, and a clamping ring matching the buckle is provided on the external hanging tube 201. After the freeze-drying bottle 200 is put into the jacket 100, the jacket 100 is effectively fixed outside the freeze-dryer through the buckle to prevent movement, and the buckle is connected to the external hanging tube 201 on the freeze-dryer.
[0036] The specific usage process of the above-mentioned multifunctional jacket for assisting freeze-drying is as follows:
[0037] The operator fixes the pre-frozen freeze-drying bottle 200 on the valve 202 of the external hanging tube 201 of the freeze-dryer, turns on the freeze-drying mode, then places the freeze-drying bottle 200 in the inner container 104 of the multifunctional jacket 100. After stabilizing the jacket 100, the housing 101 is closed upward from the middle of the bottom by using the hinge 103, and the jacket 100 is clamped on the external hanging tube 201 of the freeze-dryer through the buckle. Because when the sample pre-frozen at a high melting point is transferred to the freeze-dryer for freeze-drying, even a short period of time will cause the sample to melt. After the jacket 100 and the freeze-drying bottle 200 are fixed, dry ice can be added or supplemented through the pipeline 106, so that the sample can also maintain a low temperature state as much as possible at the beginning of freeze-drying, delaying the melting phenomenon of the sample and improving the success rate of freeze-drying. During the freeze-drying process, since both the housing 101 and the inner container 104 of the jacket 100 use light-shielding materials, during the freeze-drying process, the freeze-drying process can be observed through the visual window 107 to evaluate whether further dry ice needs to be supplemented or the freeze-drying is completed.
[0038] In summary, a multifunctional jacket for assisting freeze-drying in the present utility model is adopted. A jacket for placing a freeze-drying bottle is added inside the outer shell to keep the freeze-drying bottle warm. Through the additional pipeline, dry ice can be replenished multiple times in the inner cavity of the inner liner, thereby delaying the rapid melting phenomenon of the successfully pre-frozen sample after the start of freeze-drying. This jacket is not completely sealed. During the freeze-drying process, the added dry ice can slowly sublime. While ensuring a relatively low initial temperature, the slow sublimation of dry ice causes the internal temperature to rise gently, thus realizing the freeze-drying of the sample. The structure is simple and convenient to use.
[0039] The specific embodiments of the utility model have been described above. It should be understood that the utility model is not limited to the above specific implementation manners. The equipment and structures not described in detail should be understood to be implemented in a common manner in the art; those skilled in the art can make various deformations or modifications within the scope of the claims, make several simple deductions, deformations or substitutions, which do not affect the essence of the utility model.
Claims
1. A multifunctional jacket for assisting freeze drying, characterized in that: It comprises a shell, the top of the shell is provided with an opening for the external hanging tube to pass through, the top of the shell is provided with a locking piece matching the external hanging tube at the opening, and the bottom of the shell is provided with a hinge; An inner liner is installed inside the shell, a chamber for placing a freeze-dried bottle is provided inside the inner liner, and a pipeline connected to the chamber is installed on the shell; A valve connected to the top of the freeze-drying bottle is installed at the bottom of the external hanging tube.
2. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: The shell and the inner container are provided with a visual window at the same position.
3. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: The inner container is in the shape of an open beaker.
4. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: The inner liner is a low temperature resistant inner liner.
5. A multifunctional jacket for assisting freeze-drying as claimed in claim 4, characterized in that: The inner liner is made of polyethylene, polypropylene or polytetrafluoroethylene.
6. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: Light-proof materials are added to the shell and the inner container during production.
7. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: The locking piece is a buckle, and a clamping ring matching the buckle is provided on the external hanging tube.
8. A multifunctional jacket for assisting freeze-drying as claimed in claim 1, characterized in that: The shell is made of organic material or composite material.