High-flux multifunctional crystallization reaction device

Abstract

The utility model discloses a high-flux multifunctional crystallization reaction device which comprises a stirrer, a non-magnetic sample disc is mounted at the top of the stirrer, a plurality of sample grooves are formed in the top of the sample disc, a temperature and humidity sensor is mounted on the sample disc, and non-magnetic molds can be placed in the sample grooves. Interference is avoided, and meanwhile, reaction bottles with different sizes can be adapted; the isolation hood is arranged on the sample disc in a covering mode, an air inlet assembly and an exhaust assembly are installed on the two opposite sides of the isolation hood respectively, the controller and the temperature and humidity sensor are wirelessly connected with the controller for data interaction, and the controller is in control connection with the stirrer and the air inlet assembly respectively; air exchange can be reduced, organic gas in the reactor is prevented from escaping to pollute the laboratory environment, a nitrogen purging function is added, accumulation of condensed water in a sample disc can be reduced, the practicability and convenience of an existing device are improved, the device is in a closed environment, on the premise that a movable door is not opened, a sample can be taken for observation, and the operation is convenient. And the exchange between the device and the outside is reduced.

Description

Technical Field

[0001] The utility model relates to a crystallization reaction device, in particular to a high-throughput multifunctional crystallization reaction device. Background Art

[0002] The crystal form of a drug is an important property of solid drugs and has a significant impact on drug development. A large number of screening experiments need to be set up at each stage of drug crystal development, and crystal screening experiments often have a long cycle and many influencing factors. Conventional crystallization platforms can no longer meet the needs of high-throughput crystal screening experiments.

[0003] For high-throughput crystallization platforms, existing devices have relatively few functions and only have conventional stirring and heating / cooling functions. Many problems will still be encountered during use. For example, during the cooling process, the crystallization platform will produce condensed water. The accumulation of condensed water will bring potential sample contamination risks to the sampling process, especially when the amount of screening experiment materials is small, a small amount of water will have a significant impact on the results; condensed water may also corrode and damage the instrument circuit board. In addition, due to the large number of high-throughput experiments, different reaction vials may interfere with each other when using magnetic stirring, affecting the stirring efficiency and thus affecting the experimental results; and in actual use, there are often experimental groups with different batches and different reaction times. If no distinction is made, this will make the sampling process require cumbersome operations such as taking, observing, and recording, which in turn affects the actual efficiency of the entire high-throughput experiment. In view of the above shortcomings, it is necessary to develop a high-throughput crystallization platform that can improve the experimental efficiency, which has an important practical role. Utility Model Content

[0004] The technical problem to be solved by the utility model is that the existing high-throughput crystallization reaction device has a single function and cannot intuitively distinguish and display samples of different batches and different reaction times, resulting in low sampling efficiency. A large amount of condensed water is often generated during the cooling process of the reactor, which not only affects the sampling efficiency, but also causes potential sample contamination. In addition, since crystallization experiments usually use organic reagents that are harmful to the human body, a small amount of organic solvents will also evaporate and escape during the sampling or reaction process, thereby affecting laboratory safety. The utility model provides a high-throughput multifunctional crystallization reaction device, which adds an isolation cover to the high-throughput crystallization reaction device to reduce air exchange and prevent organic gas in the reactor from escaping and polluting the laboratory environment. A nitrogen purge function is added to reduce the accumulation of condensed water in the sample tray, thereby improving the practicality and convenience of the existing device. The device is a closed environment, and samples can be taken for observation without opening the movable door to reduce the exchange between the device and the outside world. The structure is simple and easy to use, which is used to solve the defects caused by the prior art.

[0005] In order to solve the above technical problems, the utility model provides the following technical solutions:

[0006] A high-throughput multifunctional crystallization reaction device, comprising a stirrer, a non-magnetic sample tray is installed on the top of the stirrer, a plurality of sample slots are opened on the top of the sample tray, a temperature and humidity sensor is installed on the sample tray, a non-magnetic mold can be placed in the sample slot, and reaction bottles of different sizes can be adapted while avoiding interference;

[0007] An isolation cover is arranged on the sample plate, and an air intake component and an exhaust component are respectively installed on opposite sides of the isolation cover.

[0008] A controller, wherein the temperature and humidity sensor is connected to the controller wirelessly to exchange data, and the controller controls the stirrer and the air intake assembly respectively;

[0009] The controller is connected to a computer and has corresponding software that can register sample information, the position on the sample tray, and the required reaction time, so that the controller can control the light strip corresponding to the sample slot. The computer has a timing function that can record the reaction time of each reactor.

[0010] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein the bottom of the sample tray is a hollow chamber, the side of the sample tray is provided with a water inlet pipe and a drain pipe connected to the hollow chamber, and the water inlet pipe and the drain pipe are respectively externally connected to the liquid supply component.

[0011] In the above-mentioned high-throughput multifunctional crystallization reaction device, a groove is provided on the sample plate, a water level sensor is installed on the groove, and the water level sensor is connected to the controller wirelessly for data exchange.

[0012] In the above-mentioned high-throughput multifunctional crystallization reaction device, a door body is installed on one side of the isolation cover, and a sealing rubber sleeve is installed on the side of the isolation cover where the door body is provided.

[0013] In the above-mentioned high-throughput multifunctional crystallization reaction device, the door body can be rotatably connected to the isolation cover.

[0014] In the above-mentioned high-throughput multifunctional crystallization reaction device, glove holes are installed on opposite sides of the isolation cover, and the glove holes are provided with rubber gloves installed on the isolation cover.

[0015] In the above-mentioned high-throughput multifunctional crystallization reaction device, the isolation cover is transparent or brown, and the isolation cover is made of glass or acrylic.

[0016] In the above-mentioned high-throughput multifunctional crystallization reaction device, the stirrer is a magnetic stirrer, the sample tray is a stainless steel tray, and there are 12 sample slots evenly distributed.

[0017] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein the sample slot is circular, the diameter of the sample slot is 2.73cm±0.01cm, and the periphery of the sample slot is provided with a light strip installed on the sample tray, the light strip is preferably an LED light strip, and the controller controls the connection of the light strip. For the sample slot that has reached the preset reaction time, the controller controls the light strip to light up, and the color of the light strip can be set to serve as a prompt.

[0018] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein the air intake assembly includes an air intake pipe and an air intake solenoid valve installed on the air intake pipe, the air intake pipe is externally connected to an air source, and the air source is nitrogen. It is mainly aimed at the problem that a large amount of condensed water is generated due to low temperature in the existing high-throughput crystallization platform. The additional nitrogen gas for purging can detect whether condensed water is generated through the water level sensor, and then feedback to the controller, and the nitrogen flux is adjusted by the preset value, and the generation of condensed water is avoided by replacing the air containing moisture. In addition, a switch sensor is installed at the door body. When it is detected that the door body is opened or the humidity is high, the nitrogen flux will also be increased to avoid the generation of condensed water.

[0019] The exhaust assembly comprises an exhaust pipe and an exhaust solenoid valve installed on the exhaust pipe;

[0020] The controller controls and connects the intake solenoid valve and the exhaust solenoid valve respectively.

[0021] The technical solution provided by the high-throughput multifunctional crystallization reaction device of the utility model has the following technical effects:

[0022] An isolation cover is added to the high-throughput crystallization reaction device to reduce air exchange and prevent the escape of organic gas in the reactor from polluting the laboratory environment. The addition of a nitrogen purge function can reduce the accumulation of condensed water in the sample tray and improve the practicality and convenience of the existing device. The device is a closed environment, and samples can be taken for observation without opening the movable door to reduce the exchange between the device and the outside world. The structure is simple and easy to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the structure of a high-throughput multifunctional crystallization reaction device of the utility model;

[0024] Figure 2 This is a front structural schematic diagram of a high-throughput multifunctional crystallization reaction device of the utility model;

[0025] Figure 3 It is a side view structural schematic diagram of a high-throughput multifunctional crystallization reaction device of the utility model.

[0026] The reference numerals are as follows:

[0027] Agitator 100, sample tray 200, isolation cover 300, controller 400, sample slot 201, water inlet pipe 202, drain pipe 203, groove 204, water level sensor 205, temperature and humidity sensor 206, light strip 207, air inlet pipe 301, air inlet solenoid valve 302, exhaust pipe 303, exhaust solenoid valve 304, door body 305, switch sensor 306, glove hole 307, handle 308. DETAILED DESCRIPTION

[0028] In order to make the technical means, creative features, objectives and effects achieved by the utility model easy to understand, the technical solutions in the embodiments of the utility model are clearly and completely described below in combination with specific illustrations. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments.

[0029] Based on the embodiments of the present utility model, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present utility model.

[0030] It should be noted that the structures, proportions, sizes, etc. illustrated in the drawings in this specification are only used to match the contents disclosed in the specification so that people familiar with this technology can understand and read them. They are not used to limit the conditions under which the present utility model can be implemented, so they have no substantive technical significance. Any structural modification, change in proportional relationship or adjustment of size should still fall within the scope of the technical contents disclosed in the present utility model without affecting the effects and purposes that can be achieved by the present utility model.

[0031] At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" cited in this specification are only for the convenience of description and are not used to limit the scope of the implementation of the present utility model. Changes or adjustments to their relative relationships should be regarded as the scope of the implementation of the present utility model without substantially changing the technical content.

[0032] A preferred embodiment of the utility model is to provide a high-throughput multifunctional crystallization reaction device, the purpose of which is to add an isolation cover to the high-throughput crystallization reaction device to reduce air exchange and prevent the escape of organic gas in the reactor from polluting the laboratory environment, and the addition of a nitrogen purge function can reduce the accumulation of condensed water in the sample tray, thereby improving the practicality and convenience of the existing device. The device is a closed environment, and samples can be taken for observation without opening the movable door to reduce the exchange between the device and the outside world. The structure is simple and easy to use.

[0033] like Figure 1-3As shown, a high-throughput multifunctional crystallization reaction device comprises a stirrer 100, a non-magnetic sample tray 200 is installed on the top of the stirrer 100, a plurality of sample slots 201 are opened on the top of the sample tray 200, a temperature and humidity sensor 206 is installed on the sample tray 200, and a non-magnetic mold can be placed in the sample slot 201 to avoid interference and adapt to reaction bottles of different sizes;

[0034] The isolation cover 300 is disposed on the sample plate 200, and an air intake component and an exhaust component are respectively installed on opposite sides of the isolation cover 300.

[0035] The controller 400 and the temperature and humidity sensor 206 are connected to the controller 400 via wireless to exchange data. The controller 400 controls the connected agitator 100 and the air intake assembly respectively. The temperature and humidity sensor 206 detects the temperature of the sample tray 200 and the humidity in the isolation cover 300 in real time. The temperature of the sample tray 200 is normally controlled by the external liquid supply assembly. Here, the temperature detection can be recorded as the internal sample tray 200 detection temperature. If the temperature of the sample tray 200 and the temperature controlled by the external liquid supply assembly differ too much, an alarm is given. The temperature difference range can be customized. Humidity detection is to control humidity. Some reactions require low humidity conditions. If the humidity is too high, nitrogen can be used to take away the wet air to reduce the humidity.

[0036] The controller 400 is connected to a computer and has corresponding software that can register sample information, the position on the sample tray 200, and the required reaction time, so that the controller 400 can control the light strip 207 corresponding to the sample slot. The computer has a timing function and can record the reaction time of each reactor.

[0037] like Figure 2-3 As shown, the above-mentioned high-throughput multifunctional crystallization reaction device, wherein the bottom of the sample tray 200 is a hollow chamber, and the side of the sample tray 200 is provided with a water inlet pipe 202 and a drain pipe 203 connected to the hollow chamber, the water inlet pipe 202 and the drain pipe 203 are respectively connected to the liquid supply component, the liquid supply component can be temperature-regulated to adjust the temperature of the liquid in the hollow chamber so as to adjust the reaction temperature, and the liquid can be common liquid heat transfer media such as water, oil, ethylene glycol, etc.

[0038] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein a groove 204 is opened on the sample plate 200, and a water level sensor 205 is installed on the groove 204. The water level sensor 205 is connected to the controller 400 via wireless for data exchange. The groove 204 is an inclined groove for collecting condensate. The water level sensor 205 detects the condensate in the groove 204 in real time and feeds back to the controller 400. The controller 400 controls the air intake solenoid valve 302 to adjust the intake of nitrogen and controls the exhaust solenoid valve 304 to adjust the output of nitrogen, thereby reducing the use of nitrogen when there is no condensed water and saving nitrogen. The water level sensor 205 detects whether there is condensed water and decides whether to pass nitrogen for purging.

[0039] In the above-mentioned high-throughput multifunctional crystallization reaction device, a door body 305 is installed on one side of the isolation cover 300, and a sealing rubber sleeve is installed on the side of the isolation cover 300 where the door body 305 is installed, so that the interior of the isolation cover 300 can be sealed.

[0040] In the above-mentioned high-throughput multifunctional crystallization reaction device, the door body 305 can be rotatably connected to the isolation cover 300, which is convenient for opening to take out and put samples, and a handle 308 is installed on the door body 305 for easy operation.

[0041] In the above-mentioned high-throughput multifunctional crystallization reaction device, glove holes 307 are installed on opposite sides of the isolation cover 300, and the glove holes 307 are provided with rubber gloves installed on the isolation cover 300, so that sampling and observation can be achieved without opening the movable door.

[0042] In the above-mentioned high-throughput multifunctional crystallization reaction device, the isolation cover 300 is transparent or brown, and is made of glass or acrylic, so that the light-shielding condition can be met as needed.

[0043] The high-throughput multifunctional crystallization reaction device described above, wherein the stirrer 100 is a magnetic stirrer 100, the sample tray 200 is a stainless steel tray, and there are 12 sample slots 201 evenly distributed. The number and size of the sample slots 201 can be designed according to requirements to meet the requirements of different experimental quantities and sample bottle sizes;

[0044] Different types of non-magnetic molds can be placed in the sample slot 201. The non-magnetic molds are isolated from each other in the vertical direction to avoid stirring interference between reaction vials, and there is no isolation material at the bottom to ensure that magnetic stirring can proceed smoothly. Different types of non-magnetic molds also increase the applicable models of reaction vials (including but not limited to 2mL, 8mL, 20mL, and 40mL reaction vials).

[0045] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein the sample slot 201 is circular, the diameter of the sample slot 201 is 2.73cm±0.01cm, and the periphery of the sample slot 201 is provided with a light strip 207 installed on the sample tray 200. The light strip 207 is preferably an LED light strip 207. The controller 400 controls the connection of the light strip 207. For the sample slot 201 that has reached the preset reaction time, the controller 400 controls the light strip 207 to light up. The color of the light strip 207 can be set to serve as a prompt, and can display three colors: green, yellow, and red.

[0046] The above-mentioned high-throughput multifunctional crystallization reaction device, wherein the air intake component includes an air intake pipe 301 and an air intake solenoid valve 302 installed on the air intake pipe 301, the air intake pipe 301 is externally connected to an air source, and the air source is nitrogen. It is mainly aimed at the problem that a large amount of condensed water is generated due to low temperature in the existing high-throughput crystallization platform. The additional nitrogen gas for purging can detect whether condensed water is generated through a sensor, and feedback is given to the controller 400. The nitrogen flux is adjusted by a preset value, and the generation of condensed water is avoided by replacing the air containing moisture. In addition, a switch sensor 306 (for detecting the switch status of the door body 305) is installed at the door body 305. When it is detected that the door body 305 is opened or the humidity is high, the nitrogen flux will also be increased to avoid the generation of condensed water.

[0047] The exhaust assembly includes an exhaust pipe 303 and an exhaust solenoid valve 304 installed on the exhaust pipe 303;

[0048] The air inlet pipe 301 is arranged on the upper side of the isolation cover 300, and the exhaust pipe 303 is arranged on the lower side of the isolation cover 300. Since the density of nitrogen is slightly lower than that of air, the height of the exhaust pipe 303 should be lower than that of the air inlet pipe 301, so as to improve the gas exchange efficiency;

[0049] The controller 400 controls the intake solenoid valve 302 and the exhaust solenoid valve 304 respectively.

[0050] When in use, the operator needs to open the door 305, and put the sample bottles required for several reactions into the sample slots 201 on the sample tray 200, add non-magnetic molds to separate them, and then perform a crystallization reaction. Then, the operator needs to close the door, and then the operator needs to register the sample in the controller 400. The registration information includes the reaction position and the expected reaction time. After the setting is completed, the light strip 207 next to the sample slot 201 displays a green light. When the sample has 25% of the reaction time left, the light strip 207 displays a yellow light. When the reaction time exceeds the set reaction time, the light strip 207 displays a red light. During the entire reaction time, the operator can use the glove hole 307 to take and observe the sample. Since there is no need to open the door 305, the gas exchange with the outside world is reduced during the operation.

[0051] When condensed water is generated during the sample cooling process, the generated condensed water can flow downward along the inclined inner wall of the sample plate 200 to the inside of the groove 204. A water level sensor 205 is provided inside the groove 204. When it comes into contact with water, the signal can be transmitted to the controller 400. The controller 400 controls the opening of the nitrogen intake solenoid valve 302 and the exhaust solenoid valve 304, so that the nitrogen slowly passes into the isolation cover 300. When the moisture is entrained by the nitrogen and escapes from the air outlet, the water level sensor 205 can transmit the signal to the controller 400. The controller 400 controls the closing of the nitrogen intake solenoid valve 302 and the exhaust solenoid valve 304, thereby closing the nitrogen from entering the isolation cover 300.

[0052] When the door 305 of the isolation cover 300 is opened, the door opening sensor 306 transmits a signal to the controller 400, and the controller 400 controls the opening of the nitrogen intake solenoid valve 302 and the exhaust solenoid valve 304 to reduce air entry, take away water vapor, and reduce condensation.

[0053] When the humidity in the isolation cover 300 is high, the humidity sensor 206 transmits a signal to the controller 400, and the controller 400 controls the opening of the nitrogen inlet solenoid valve 302 and the exhaust solenoid valve 304 to take away the moist air in time and reduce condensation.

[0054] In summary, the utility model is a high-throughput multifunctional crystallization reaction device, which adds an isolation cover to the high-throughput crystallization reaction device to reduce air exchange and prevent the escape of organic gas in the reactor from polluting the laboratory environment, and is equipped with a nitrogen purge function to reduce the accumulation of condensed water in the sample tray, thereby improving the practicality and convenience of the existing device. The device is a closed environment, and samples can be taken for observation without opening the movable door to reduce the exchange between the device and the outside world. The structure is simple and easy to use.

[0055] The above describes the specific embodiments of the utility model. It should be understood that the utility model is not limited to the above specific embodiments, and the devices and structures not described in detail should be understood to be implemented in a common manner in the art; those skilled in the art can make various modifications or modifications within the scope of the claims to make some simple deductions, deformations or substitutions, which does not affect the substantive content of the utility model.

Claims

1. A high-throughput multifunctional crystallization reaction device, characterized in that: It comprises a stirrer, a non-magnetic sample tray is installed on the top of the stirrer, a plurality of sample slots are opened on the top of the sample tray, and a temperature and humidity sensor is installed on the sample tray; An isolation cover is arranged on the sample plate, and an air intake component and an exhaust component are respectively installed on opposite sides of the isolation cover. The temperature and humidity sensor is connected to the controller wirelessly to exchange data, and the controller controls the stirrer and the air intake assembly respectively.

2. A high-throughput multifunctional crystallization reaction device according to claim 1, characterized in that: The bottom of the sample tray is a hollow chamber, and the side of the sample tray is provided with a water inlet pipe and a drain pipe communicating with the hollow chamber, and the water inlet pipe and the drain pipe are respectively externally connected to the liquid supply component.

3. A high-throughput multifunctional crystallization reaction device as claimed in claim 2, characterized in that: The sample tray is provided with a groove, and a water level sensor is installed on the groove. The water level sensor is connected to the controller wirelessly for data exchange.

4. A high-throughput multifunctional crystallization reaction device as claimed in claim 1, characterized in that: A door body is installed on one side of the isolation cover, and a sealing rubber sleeve is installed on the side of the isolation cover where the door body is installed.

5. A high-throughput multifunctional crystallization reaction device as claimed in claim 4, characterized in that: The door body is rotatably connected to the isolation cover.

6. A high-throughput multifunctional crystallization reaction device as claimed in claim 1, characterized in that: Glove holes are installed on opposite sides of the isolation cover, and the glove holes are provided with rubber gloves installed on the isolation cover.

7. A high-throughput multifunctional crystallization reaction device as claimed in claim 1, characterized in that: The isolation cover is transparent or brown and is made of glass or acrylic.

8. A high-throughput multifunctional crystallization reaction device as claimed in claim 7, characterized in that: The stirrer is a magnetic stirrer, the sample tray is a stainless steel tray, and there are 12 sample slots evenly distributed.

9. A high-throughput multifunctional crystallization reaction device according to claim 1, characterized in that: The sample groove is circular, and the diameter of the sample groove is 2.73 cm±0.01 cm.

10. A high-throughput multifunctional crystallization reaction device according to claim 1, characterized in that: The air intake assembly comprises an air intake pipe and an air intake solenoid valve installed on the air intake pipe, and the air intake pipe is externally connected to an air source; The exhaust assembly comprises an exhaust pipe and an exhaust solenoid valve installed on the exhaust pipe; The controller controls and connects the intake solenoid valve and the exhaust solenoid valve respectively.

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