Traditional Chinese medicine percolation extraction system with online monitoring control function

Abstract

The utility model discloses a traditional Chinese medicine percolation extraction system with an on-line monitoring control function, which belongs to the technical field of traditional Chinese medicine pharmacy and comprises a percolation extraction module, an on-line detection module and an automatic control module. The on-line detection module comprises an optical image acquisition device, a physical quantity sensor detection device and a spectrum detection device which are arranged in sequence, and the on-line detection module is used for detecting the percolation liquid generated in the percolation extraction module and acquiring optical images, pH values, conductivity, oxidation-reduction potentials and spectrum information of the percolation liquid; the automatic control module is used for controlling the percolation extraction module to change percolation process parameters and controlling the online detection module to collect percolation process data. Through the arrangement of the on-line detection module, the state and the index component content of percolation liquid can be comprehensively detected in a multi-mode manner, the quality of the traditional Chinese medicine percolation process can be better controlled, the production efficiency is improved, the resource waste is reduced, and the production cost is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of traditional Chinese medicine pharmaceutical manufacturing, in particular to a traditional Chinese medicine percolation extraction system with online monitoring and control functions. Background Art

[0002] At present, the control of drug quality in the pharmaceutical production industry is gradually developing towards the "Quality by Design (QbD)" model. QbD is a drug quality control concept promoted to improve drug quality, encourage technological innovation and reduce the difficulty of supervision. It is widely used in drug and pharmaceutical process development. QbD emphasizes in-depth understanding of drug quality and pharmaceutical process laws, and ensures drug quality by improving the level of process quality control. At the same time, QbD emphasizes that the focus of drug quality control should be shifted from finished product inspection to the control of raw materials, intermediates and pharmaceutical processes. In the production process of traditional Chinese medicine preparations, research on Chinese medicine quality control is mostly focused on finished preparations, and quality control of intermediates and pharmaceutical processes is very lacking. In addition, the implementation of intelligent manufacturing has become an inevitable trend for the high-quality development of the Chinese medicine industry. Therefore, it is necessary to develop a pharmaceutical system with online monitoring and control functions.

[0003] The percolation process of traditional Chinese medicine is widely used in the production of traditional Chinese medicines and is crucial for the extraction of effective ingredients from some traditional Chinese medicines. In the current production process, the percolation process of traditional Chinese medicine is mostly detected offline, which has the disadvantages of complex pre-treatment, delayed detection, and inability to recover the liquid medicine. At present, the industry lacks online detection devices and automated control systems that can sense intelligently. The percolation production process is relatively extensive, which is not conducive to the quality control of intermediates, affects the batch-to-batch consistency of intermediates, and may affect the quality of finished preparations.

[0004] A Chinese patent document with publication number CN220584189U discloses an online detection device for a Chinese medicine extraction process, which includes an extraction tank, and a detection device is arranged on one side of the extraction tank. By arranging the detection device, samples can be extracted for detection during the extraction process of the Chinese medicine, thereby achieving the effect of online detection. A Chinese patent document with publication number CN219915375U discloses an online detection system for total solids in a Chinese medicine extract, which includes a liquid inlet pipeline, a liquid outlet pipeline, a detection pipeline, a detection probe, and a refractometer, wherein the detection probe is arranged in the detection pipeline, and the detection probe is connected to the refractometer located outside the detection pipeline, and the total solids content in the extract is displayed by a digital refractometer, thereby achieving online rapid detection of total solids.

[0005] The information obtained by the above-mentioned online detection device is not rich enough and it is difficult to fully reflect the state of the percolation liquid and the percolation process. Therefore, it is necessary to develop a new type of traditional Chinese medicine percolation extraction system with online monitoring and control functions. Utility Model Content

[0006] In order to fill the blank of online detection and automatic control in the process of Chinese medicine percolation, the utility model provides a Chinese medicine percolation extraction system with online monitoring and control functions.

[0007] The specific technical solutions adopted are as follows:

[0008] A Chinese medicine percolation extraction system with online monitoring and control functions comprises: a percolation extraction module, an online detection module and an automatic control module; the online detection module comprises an optical image acquisition device, a physical quantity sensor detection device and a spectrum detection device which are arranged in sequence, the online detection module detects the percolation liquid generated in the percolation extraction module, and collects the optical image, pH value, conductivity, redox potential and spectrum information of the percolation liquid; the automatic control module is used to control and / or monitor the percolation process of the percolation extraction module and the detection process of the online detection module.

[0009] The utility model can comprehensively detect the state and index component content of the percolation liquid in a multi-modal manner through the arrangement of the online detection module, so as to better control the quality of the percolation process of traditional Chinese medicine.

[0010] Optionally, the percolation extraction module includes a liquid storage container, a percolation column and a peristaltic pump.

[0011] Specifically, the liquid storage container is used to buffer the percolation solvent, and the percolation solvent is pumped into the percolation column under the action of the peristaltic pump to carry out the percolation process, and the obtained percolation liquid is pumped into the online detection module for detection under the action of the peristaltic pump.

[0012] Preferably, the percolation column comprises a glass column and an upper cover, the column is hollow and is used to contain the medicinal materials to be percolated, the upper cover is provided with a liquid inlet for introducing the percolation solvent, and the lower end of the percolation column is provided with a liquid outlet.

[0013] The physical quantity sensor detection device comprises a conductivity sensor, a pH sensor and an oxidation-reduction potential sensor.

[0014] Preferably, the spectral detection device includes a near-infrared spectrometer and an ultraviolet spectrometer.

[0015] Optionally, the online detection module also includes a percolation liquid collector for collecting the percolation liquid after detection.

[0016] The automation control module includes a control computer, on which control software is installed, which can visualize and store the data detected by the online detection module. The control software uses RS485 serial communication to establish a communication connection with the online detection module and uses TCP / IP protocol to realize Ethernet wireless communication.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] (1) The utility model provides a Chinese medicine percolation extraction system with online monitoring and control functions. The system can obtain multimodal data such as optical images, physical quantities, and spectra of the percolate, and can visualize and store the collected detection data in real time, laying a solid foundation for the subsequent establishment of training models and formulation of quality control strategies.

[0019] (2) The Chinese medicine percolation extraction system with online monitoring and control function provided by the utility model can realize online monitoring of the Chinese medicine percolation process and the content of index components by online collection of detection data of the percolation process, which is helpful for studying the percolation process and percolation rules, facilitating timely discovery of abnormal conditions, and indicating the end point of the percolation process. The Chinese medicine percolation extraction system fills the gap in online detection of Chinese medicine percolation production, introduces multi-modal detection equipment, can effectively ensure the full percolation of index components in the Chinese medicine percolation process, and improves production efficiency, reduces resource waste, and reduces production costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of the traditional Chinese medicine percolation extraction system with online monitoring and control functions.

[0021] Among them, the accompanying drawings are marked as: 1-liquid storage container, 2-first peristaltic pump, 3-percolation column, 4-second peristaltic pump, 5-optical image acquisition device, 6-physical quantity sensor detection device, 7-spectral detection device, 8-percolation liquid collector, 9-control computer, 10-conductivity sensor, 11-pH sensor, 12-oxidation-reduction potential sensor, 13-near infrared spectrometer, 14-ultraviolet spectrometer. DETAILED DESCRIPTION

[0022] The technical solution of the utility model will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the utility model, rather than all of the embodiments. It should be understood that the specific embodiments described here are only used to explain the utility model, and are not used to limit the utility model.

[0023] Example 1

[0024] like Figure 1As shown, the utility model provides a Chinese medicine percolation extraction system with online monitoring and control functions, the Chinese medicine percolation extraction system comprises a percolation extraction module, an online detection module and an automatic control module, wherein the percolation extraction module comprises a liquid storage container 1, a first peristaltic pump 2, a percolation column 3 and a second peristaltic pump 4, the liquid storage container is used to cache the percolation solvent (such as ethanol, a mixture of ethanol and water, etc.), the liquid storage container 1 is connected to the liquid inlet of the percolation column 3 through the first peristaltic pump 2 with a hose; the online detection module detects the percolation liquid generated in the percolation extraction module, collects the optical image, pH value, conductivity, redox potential and spectral information of the percolation liquid, comprises an optical image acquisition device 5, a physical quantity sensor detection device 6 and a spectral detection device 7 which are arranged in sequence, the liquid outlet of the percolation column 3 is connected to the optical image acquisition device 5 through the second peristaltic pump 4 with a hose The liquid outlet of the optical image acquisition device 5 is connected to the liquid inlet of the physical quantity sensor detection device 6. The physical quantity sensor detection device 6 is equipped with a conductivity sensor 10, a pH sensor 11 and an oxidation-reduction potential sensor 12, which are used to collect the conductivity, pH value and oxidation-reduction potential of the leachate flowing out of the optical image acquisition device 6. The liquid outlet of the physical quantity sensor detection device 6 is connected to the liquid inlet of the spectrum detection device 7. The spectrum detection device 7 includes a near-infrared spectrometer 13 and an ultraviolet spectrometer 14 connected in series. The liquid outlet of the spectrum detection device 7 is connected to the percolation liquid collector 8; the automation control module includes a control computer 9, which is used to control and / or monitor the percolation process of the percolation extraction module and the detection process of the online detection module. The control computer 9 is also equipped with control software, which can visualize and store the data detected by the online detection module.

[0025] When using the utility model system to perform online monitoring and control of the percolation process, the specific method is as follows:

[0026] The percolation solvent required for percolation is placed in a liquid storage container 1, and the Chinese medicinal materials to be percolated are placed in a percolation column 3. The control software (Chinese medicinal materials percolation process measurement and control system) installed in the control computer 9 controls the first peristaltic pump 2 and the second peristaltic pump 4 to open and set an appropriate flow rate. The percolation solvent is pumped into the percolation column 3 for percolation extraction under the action of the first peristaltic pump 2, and the obtained percolation liquid is pumped into the online detection module for detection under the action of the second peristaltic pump 4. After the optical image acquisition device 5 takes a picture of the percolation liquid, the percolation liquid picture is obtained and uploaded to the cloud server and displayed on the control computer 9. The percolation liquid flows into the physical quantity sensor detection device 6, and the conductivity, pH value and redox potential are detected by the built-in conductivity sensor 10, pH sensor 11 and redox potential sensor 12. The user can view the real-time physical quantity detection data in the control computer 9. Subsequently, the percolation liquid flows into the spectrum detection device 7. After being detected by the near-infrared spectrometer 13 and the ultraviolet spectrometer 14 connected in series, the user can view the real-time spectrum detection information in the control computer 9.

[0027] The embodiments described above provide a detailed description of the technical solution of the utility model. It should be understood that the above are only specific embodiments of the utility model and are not intended to limit the utility model. Any modifications, supplements or similar substitutions made within the scope of the principles of the utility model should be included in the protection scope of the utility model.

Claims

1. A Chinese medicine percolation extraction system with online monitoring and control function, characterized in that: include: Percolation extraction module, online detection module and automation control module; The online detection module includes an optical image acquisition device, a physical quantity sensor detection device and a spectrum detection device which are arranged in sequence. The online detection module detects the percolation liquid generated in the percolation extraction module and collects the optical image, pH value, conductivity, redox potential and spectrum information of the percolation liquid; the automatic control module is used to control and / or monitor the percolation process of the percolation extraction module and the detection process of the online detection module.

2. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 1, characterized in that: The percolation extraction module comprises a liquid storage container, a percolation column and a peristaltic pump.

3. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 2 is characterized in that: The liquid storage container is used to buffer the percolation solvent. The percolation solvent is pumped into the percolation column by the peristaltic pump to carry out the percolation process. The obtained percolation liquid is pumped into the online detection module for detection by the peristaltic pump.

4. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 1, characterized in that: The physical quantity sensor detection device comprises a conductivity sensor, a pH sensor and an oxidation-reduction potential sensor.

5. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 1, characterized in that: The spectrum detection device comprises a near-infrared spectrometer and an ultraviolet spectrometer.

6. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 1, characterized in that: The online detection module also includes a permeate collector.

7. The Chinese medicine percolation extraction system with online monitoring and control function according to claim 1, characterized in that: The automation control module comprises a control computer, on which control software is installed, which can visualize and store the data detected by the online detection module.

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